-- dump date 20140619_043547 -- class Genbank::misc_feature -- table misc_feature_note -- id note 758678000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 758678000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 758678000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678000004 Walker A motif; other site 758678000005 ATP binding site [chemical binding]; other site 758678000006 Walker B motif; other site 758678000007 arginine finger; other site 758678000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 758678000009 DnaA box-binding interface [nucleotide binding]; other site 758678000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 758678000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 758678000012 putative DNA binding surface [nucleotide binding]; other site 758678000013 dimer interface [polypeptide binding]; other site 758678000014 beta-clamp/clamp loader binding surface; other site 758678000015 beta-clamp/translesion DNA polymerase binding surface; other site 758678000016 S4 domain; Region: S4_2; pfam13275 758678000017 recombination protein F; Reviewed; Region: recF; PRK00064 758678000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 758678000019 Walker A/P-loop; other site 758678000020 ATP binding site [chemical binding]; other site 758678000021 Q-loop/lid; other site 758678000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678000023 ABC transporter signature motif; other site 758678000024 Walker B; other site 758678000025 D-loop; other site 758678000026 H-loop/switch region; other site 758678000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 758678000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000029 Mg2+ binding site [ion binding]; other site 758678000030 G-X-G motif; other site 758678000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 758678000032 anchoring element; other site 758678000033 dimer interface [polypeptide binding]; other site 758678000034 ATP binding site [chemical binding]; other site 758678000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 758678000036 active site 758678000037 putative metal-binding site [ion binding]; other site 758678000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 758678000039 DNA gyrase subunit A; Validated; Region: PRK05560 758678000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 758678000041 CAP-like domain; other site 758678000042 active site 758678000043 primary dimer interface [polypeptide binding]; other site 758678000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678000050 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 758678000051 HTH domain; Region: HTH_11; pfam08279 758678000052 3H domain; Region: 3H; pfam02829 758678000053 Uncharacterized conserved protein [Function unknown]; Region: COG2006 758678000054 Domain of unknown function (DUF362); Region: DUF362; pfam04015 758678000055 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678000056 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 758678000057 hypothetical protein; Validated; Region: PRK00068 758678000058 Uncharacterized conserved protein [Function unknown]; Region: COG1615 758678000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 758678000060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 758678000061 Predicted dehydrogenase [General function prediction only]; Region: COG0579 758678000062 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758678000063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758678000064 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 758678000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 758678000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 758678000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 758678000068 dimer interface [polypeptide binding]; other site 758678000069 active site 758678000070 motif 1; other site 758678000071 motif 2; other site 758678000072 motif 3; other site 758678000073 potential frameshift: common BLAST hit: gi|339445139|ref|YP_004711143.1| trypsin-like serine protease 758678000074 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 758678000075 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 758678000076 ABC1 family; Region: ABC1; cl17513 758678000077 Uncharacterized conserved protein [Function unknown]; Region: COG3937 758678000078 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 758678000079 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 758678000080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678000081 Walker A motif; other site 758678000082 ATP binding site [chemical binding]; other site 758678000083 Walker B motif; other site 758678000084 arginine finger; other site 758678000085 methionine gamma-lyase; Provisional; Region: PRK06234 758678000086 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 758678000087 homodimer interface [polypeptide binding]; other site 758678000088 substrate-cofactor binding pocket; other site 758678000089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678000090 catalytic residue [active] 758678000091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 758678000092 nucleoside/Zn binding site; other site 758678000093 dimer interface [polypeptide binding]; other site 758678000094 catalytic motif [active] 758678000095 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 758678000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678000097 Walker A motif; other site 758678000098 ATP binding site [chemical binding]; other site 758678000099 Walker B motif; other site 758678000100 arginine finger; other site 758678000101 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 758678000102 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 758678000103 recombination protein RecR; Reviewed; Region: recR; PRK00076 758678000104 RecR protein; Region: RecR; pfam02132 758678000105 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 758678000106 putative active site [active] 758678000107 putative metal-binding site [ion binding]; other site 758678000108 tetramer interface [polypeptide binding]; other site 758678000109 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 758678000110 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 758678000111 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 758678000112 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 758678000113 putative NADH binding site [chemical binding]; other site 758678000114 putative active site [active] 758678000115 nudix motif; other site 758678000116 putative metal binding site [ion binding]; other site 758678000117 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758678000118 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678000119 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678000120 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 758678000121 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 758678000122 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 758678000123 putative ATP binding site [chemical binding]; other site 758678000124 putative substrate interface [chemical binding]; other site 758678000125 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 758678000126 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678000127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758678000128 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 758678000129 active site 758678000130 Fe-S cluster binding site [ion binding]; other site 758678000131 RNA polymerase factor sigma-70; Validated; Region: PRK06811 758678000132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678000133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678000134 DNA binding residues [nucleotide binding] 758678000135 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 758678000136 SurA N-terminal domain; Region: SurA_N_3; cl07813 758678000137 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758678000138 NAD-dependent deacetylase; Provisional; Region: PRK00481 758678000139 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 758678000140 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 758678000141 dimer interface [polypeptide binding]; other site 758678000142 catalytic triad [active] 758678000143 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 758678000144 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 758678000145 Cl binding site [ion binding]; other site 758678000146 oligomer interface [polypeptide binding]; other site 758678000147 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 758678000148 amidohydrolase; Region: amidohydrolases; TIGR01891 758678000149 metal binding site [ion binding]; metal-binding site 758678000150 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 758678000151 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 758678000152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758678000153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678000154 catalytic residue [active] 758678000155 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 758678000156 thymidylate kinase; Provisional; Region: PRK13975; cl17243 758678000157 Protein of unknown function (DUF970); Region: DUF970; pfam06153 758678000158 DNA polymerase III subunit delta'; Validated; Region: PRK05564 758678000159 DNA polymerase III subunit delta'; Validated; Region: PRK08485 758678000160 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 758678000161 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 758678000162 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678000163 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758678000164 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 758678000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678000166 S-adenosylmethionine binding site [chemical binding]; other site 758678000167 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 758678000168 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 758678000169 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 758678000170 arginine deiminase; Provisional; Region: PRK01388 758678000171 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 758678000172 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 758678000173 homotrimer interaction site [polypeptide binding]; other site 758678000174 zinc binding site [ion binding]; other site 758678000175 CDP-binding sites; other site 758678000176 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 758678000177 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 758678000178 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678000179 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 758678000180 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 758678000181 Fe-S cluster binding site [ion binding]; other site 758678000182 active site 758678000183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678000184 MarR family; Region: MarR_2; cl17246 758678000185 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 758678000186 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 758678000187 active site 758678000188 HIGH motif; other site 758678000189 KMSKS motif; other site 758678000190 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 758678000191 anticodon binding site; other site 758678000192 tRNA binding surface [nucleotide binding]; other site 758678000193 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 758678000194 dimer interface [polypeptide binding]; other site 758678000195 putative tRNA-binding site [nucleotide binding]; other site 758678000196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 758678000197 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 758678000198 active site 758678000199 Domain of unknown function (DUF348); Region: DUF348; pfam03990 758678000200 Domain of unknown function (DUF348); Region: DUF348; pfam03990 758678000201 G5 domain; Region: G5; pfam07501 758678000202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 758678000203 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 758678000204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678000205 S-adenosylmethionine binding site [chemical binding]; other site 758678000206 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 758678000207 HlyD family secretion protein; Region: HlyD_3; pfam13437 758678000208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678000209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678000210 Walker A/P-loop; other site 758678000211 ATP binding site [chemical binding]; other site 758678000212 Q-loop/lid; other site 758678000213 ABC transporter signature motif; other site 758678000214 Walker B; other site 758678000215 D-loop; other site 758678000216 H-loop/switch region; other site 758678000217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678000218 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678000219 FtsX-like permease family; Region: FtsX; pfam02687 758678000220 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 758678000221 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758678000222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678000223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678000224 metal binding site [ion binding]; metal-binding site 758678000225 active site 758678000226 I-site; other site 758678000227 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 758678000228 MgtC family; Region: MgtC; pfam02308 758678000229 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 758678000230 ATP cone domain; Region: ATP-cone; pfam03477 758678000231 Class III ribonucleotide reductase; Region: RNR_III; cd01675 758678000232 effector binding site; other site 758678000233 active site 758678000234 Zn binding site [ion binding]; other site 758678000235 glycine loop; other site 758678000236 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 758678000237 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 758678000238 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 758678000239 Predicted transcriptional regulators [Transcription]; Region: COG1695 758678000240 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 758678000241 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 758678000242 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 758678000243 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 758678000244 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 758678000245 HIGH motif; other site 758678000246 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 758678000247 active site 758678000248 KMSKS motif; other site 758678000249 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 758678000250 tRNA binding surface [nucleotide binding]; other site 758678000251 anticodon binding site; other site 758678000252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758678000253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758678000254 DNA binding site [nucleotide binding] 758678000255 domain linker motif; other site 758678000256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758678000257 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 758678000258 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 758678000259 Substrate binding site; other site 758678000260 Cupin domain; Region: Cupin_2; cl17218 758678000261 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 758678000262 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 758678000263 Ligand Binding Site [chemical binding]; other site 758678000264 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 758678000265 AIR carboxylase; Region: AIRC; smart01001 758678000266 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 758678000267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678000268 FeS/SAM binding site; other site 758678000269 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758678000270 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678000271 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 758678000272 substrate binding site [chemical binding]; other site 758678000273 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678000274 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678000275 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 758678000276 substrate binding site [chemical binding]; other site 758678000277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678000278 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 758678000279 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678000280 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 758678000281 active site 758678000282 ATP binding site [chemical binding]; other site 758678000283 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 758678000284 substrate binding site [chemical binding]; other site 758678000285 YabG peptidase U57; Region: Peptidase_U57; pfam05582 758678000286 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 758678000287 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 758678000288 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 758678000289 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 758678000290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678000291 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 758678000292 proposed catalytic triad [active] 758678000293 active site nucleophile [active] 758678000294 cyanophycin synthetase; Provisional; Region: PRK14016 758678000295 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758678000296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678000297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758678000298 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 758678000299 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 758678000300 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 758678000301 Spore germination protein; Region: Spore_permease; cl17796 758678000302 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 758678000303 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 758678000304 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 758678000305 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 758678000306 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 758678000307 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 758678000308 germination protein YpeB; Region: spore_YpeB; TIGR02889 758678000309 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 758678000310 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 758678000311 Ligand Binding Site [chemical binding]; other site 758678000312 Domain of unknown function (DUF814); Region: DUF814; pfam05670 758678000313 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 758678000314 CTP synthetase; Validated; Region: pyrG; PRK05380 758678000315 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 758678000316 Catalytic site [active] 758678000317 active site 758678000318 UTP binding site [chemical binding]; other site 758678000319 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 758678000320 active site 758678000321 putative oxyanion hole; other site 758678000322 catalytic triad [active] 758678000323 transcription termination factor Rho; Provisional; Region: rho; PRK09376 758678000324 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 758678000325 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 758678000326 RNA binding site [nucleotide binding]; other site 758678000327 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758678000328 Walker A motif; other site 758678000329 ATP binding site [chemical binding]; other site 758678000330 Walker B motif; other site 758678000331 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 758678000332 thymidine kinase; Provisional; Region: PRK04296 758678000333 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 758678000334 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 758678000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678000336 peptide chain release factor 1; Validated; Region: prfA; PRK00591 758678000337 This domain is found in peptide chain release factors; Region: PCRF; smart00937 758678000338 RF-1 domain; Region: RF-1; pfam00472 758678000339 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 758678000340 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 758678000341 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 758678000342 Low molecular weight phosphatase family; Region: LMWPc; cd00115 758678000343 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 758678000344 active site 758678000345 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 758678000346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678000347 active site 758678000348 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 758678000349 active site 758678000350 Zn binding site [ion binding]; other site 758678000351 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 758678000352 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 758678000353 Mg++ binding site [ion binding]; other site 758678000354 putative catalytic motif [active] 758678000355 substrate binding site [chemical binding]; other site 758678000356 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 758678000357 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 758678000358 active site 758678000359 homodimer interface [polypeptide binding]; other site 758678000360 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 758678000361 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 758678000362 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 758678000363 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 758678000364 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 758678000365 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 758678000366 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 758678000367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758678000368 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 758678000369 beta subunit interaction interface [polypeptide binding]; other site 758678000370 Walker A motif; other site 758678000371 ATP binding site [chemical binding]; other site 758678000372 Walker B motif; other site 758678000373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758678000374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 758678000375 core domain interface [polypeptide binding]; other site 758678000376 delta subunit interface [polypeptide binding]; other site 758678000377 epsilon subunit interface [polypeptide binding]; other site 758678000378 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 758678000379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758678000380 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 758678000381 alpha subunit interaction interface [polypeptide binding]; other site 758678000382 Walker A motif; other site 758678000383 ATP binding site [chemical binding]; other site 758678000384 Walker B motif; other site 758678000385 inhibitor binding site; inhibition site 758678000386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758678000387 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 758678000388 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 758678000389 gamma subunit interface [polypeptide binding]; other site 758678000390 epsilon subunit interface [polypeptide binding]; other site 758678000391 LBP interface [polypeptide binding]; other site 758678000392 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 758678000393 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 758678000394 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 758678000395 hinge; other site 758678000396 active site 758678000397 stage II sporulation protein D; Region: spore_II_D; TIGR02870 758678000398 Stage II sporulation protein; Region: SpoIID; pfam08486 758678000399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758678000400 Peptidase family M23; Region: Peptidase_M23; pfam01551 758678000401 Stage III sporulation protein D; Region: SpoIIID; pfam12116 758678000402 rod shape-determining protein Mbl; Provisional; Region: PRK13928 758678000403 MreB and similar proteins; Region: MreB_like; cd10225 758678000404 nucleotide binding site [chemical binding]; other site 758678000405 Mg binding site [ion binding]; other site 758678000406 putative protofilament interaction site [polypeptide binding]; other site 758678000407 RodZ interaction site [polypeptide binding]; other site 758678000408 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 758678000409 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 758678000410 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 758678000411 Ligand Binding Site [chemical binding]; other site 758678000412 S-adenosylmethionine synthetase; Validated; Region: PRK05250 758678000413 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 758678000414 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 758678000415 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 758678000416 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 758678000417 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 758678000418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678000419 active site 758678000420 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 758678000421 30S subunit binding site; other site 758678000422 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 758678000423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 758678000424 ATP binding site [chemical binding]; other site 758678000425 putative Mg++ binding site [ion binding]; other site 758678000426 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 758678000427 SEC-C motif; Region: SEC-C; pfam02810 758678000428 peptide chain release factor 2; Provisional; Region: PRK05589 758678000429 PCRF domain; Region: PCRF; pfam03462 758678000430 RF-1 domain; Region: RF-1; pfam00472 758678000431 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 758678000432 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 758678000433 Peptidase family M28; Region: Peptidase_M28; pfam04389 758678000434 metal binding site [ion binding]; metal-binding site 758678000435 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 758678000436 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 758678000437 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 758678000438 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 758678000439 RNA binding site [nucleotide binding]; other site 758678000440 Predicted membrane protein [Function unknown]; Region: COG3601 758678000441 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 758678000442 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 758678000443 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 758678000444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758678000445 putative active site [active] 758678000446 putative metal binding site [ion binding]; other site 758678000447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678000448 dimerization interface [polypeptide binding]; other site 758678000449 putative DNA binding site [nucleotide binding]; other site 758678000450 putative Zn2+ binding site [ion binding]; other site 758678000451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 758678000452 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 758678000453 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 758678000454 synthetase active site [active] 758678000455 NTP binding site [chemical binding]; other site 758678000456 metal binding site [ion binding]; metal-binding site 758678000457 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 758678000458 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 758678000459 HIGH motif; other site 758678000460 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 758678000461 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758678000462 active site 758678000463 KMSKS motif; other site 758678000464 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 758678000465 tRNA binding surface [nucleotide binding]; other site 758678000466 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 758678000467 active site residue [active] 758678000468 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 758678000469 HSP70 interaction site [polypeptide binding]; other site 758678000470 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 758678000471 putative active site [active] 758678000472 putative triphosphate binding site [ion binding]; other site 758678000473 dimer interface [polypeptide binding]; other site 758678000474 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 758678000475 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 758678000476 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 758678000477 intersubunit interface [polypeptide binding]; other site 758678000478 active site 758678000479 zinc binding site [ion binding]; other site 758678000480 Na+ binding site [ion binding]; other site 758678000481 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 758678000482 Predicted membrane protein [Function unknown]; Region: COG2323 758678000483 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 758678000484 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 758678000485 active site 758678000486 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 758678000487 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 758678000488 FOG: CBS domain [General function prediction only]; Region: COG0517 758678000489 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 758678000490 putative lipid kinase; Reviewed; Region: PRK13059 758678000491 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 758678000492 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 758678000493 hypothetical protein; Provisional; Region: PRK00955 758678000494 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 758678000495 PRC-barrel domain; Region: PRC; pfam05239 758678000496 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 758678000497 MgtE intracellular N domain; Region: MgtE_N; smart00924 758678000498 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 758678000499 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 758678000500 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678000501 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 758678000502 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 758678000503 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 758678000504 dimer interface [polypeptide binding]; other site 758678000505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678000506 catalytic residue [active] 758678000507 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 758678000508 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 758678000509 trimer interface [polypeptide binding]; other site 758678000510 active site 758678000511 substrate binding site [chemical binding]; other site 758678000512 CoA binding site [chemical binding]; other site 758678000513 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 758678000514 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 758678000515 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758678000516 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758678000517 putative acyl-acceptor binding pocket; other site 758678000518 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 758678000519 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758678000520 minor groove reading motif; other site 758678000521 helix-hairpin-helix signature motif; other site 758678000522 substrate binding pocket [chemical binding]; other site 758678000523 active site 758678000524 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 758678000525 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 758678000526 Malic enzyme, N-terminal domain; Region: malic; pfam00390 758678000527 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 758678000528 putative NAD(P) binding site [chemical binding]; other site 758678000529 competence damage-inducible protein A; Provisional; Region: PRK00549 758678000530 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 758678000531 putative MPT binding site; other site 758678000532 Competence-damaged protein; Region: CinA; pfam02464 758678000533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758678000534 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758678000535 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 758678000536 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 758678000537 putative oligomer interface [polypeptide binding]; other site 758678000538 putative active site [active] 758678000539 metal binding site [ion binding]; metal-binding site 758678000540 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 758678000541 VanW like protein; Region: VanW; pfam04294 758678000542 G5 domain; Region: G5; pfam07501 758678000543 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 758678000544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678000545 FeS/SAM binding site; other site 758678000546 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 758678000547 EDD domain protein, DegV family; Region: DegV; TIGR00762 758678000548 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 758678000549 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 758678000550 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 758678000551 ligand binding site [chemical binding]; other site 758678000552 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 758678000553 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758678000554 Walker A/P-loop; other site 758678000555 ATP binding site [chemical binding]; other site 758678000556 Q-loop/lid; other site 758678000557 ABC transporter signature motif; other site 758678000558 Walker B; other site 758678000559 D-loop; other site 758678000560 H-loop/switch region; other site 758678000561 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758678000562 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758678000563 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758678000564 TM-ABC transporter signature motif; other site 758678000565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758678000566 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758678000567 TM-ABC transporter signature motif; other site 758678000568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 758678000569 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 758678000570 NodB motif; other site 758678000571 active site 758678000572 catalytic site [active] 758678000573 Zn binding site [ion binding]; other site 758678000574 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 758678000575 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 758678000576 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 758678000577 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 758678000578 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 758678000579 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 758678000580 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 758678000581 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 758678000582 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 758678000583 Phosphoglycerate kinase; Region: PGK; pfam00162 758678000584 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 758678000585 substrate binding site [chemical binding]; other site 758678000586 hinge regions; other site 758678000587 ADP binding site [chemical binding]; other site 758678000588 catalytic site [active] 758678000589 triosephosphate isomerase; Provisional; Region: PRK14567 758678000590 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 758678000591 substrate binding site [chemical binding]; other site 758678000592 dimer interface [polypeptide binding]; other site 758678000593 catalytic triad [active] 758678000594 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 758678000595 phosphoglyceromutase; Provisional; Region: PRK05434 758678000596 enolase; Provisional; Region: eno; PRK00077 758678000597 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 758678000598 dimer interface [polypeptide binding]; other site 758678000599 metal binding site [ion binding]; metal-binding site 758678000600 substrate binding pocket [chemical binding]; other site 758678000601 Preprotein translocase SecG subunit; Region: SecG; pfam03840 758678000602 ribonuclease R; Region: RNase_R; TIGR02063 758678000603 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 758678000604 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 758678000605 RNB domain; Region: RNB; pfam00773 758678000606 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 758678000607 RNA binding site [nucleotide binding]; other site 758678000608 stationary phase survival protein SurE; Provisional; Region: PRK13933 758678000609 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 758678000610 SmpB-tmRNA interface; other site 758678000611 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 758678000612 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758678000613 MepB protein; Region: MepB; pfam08877 758678000614 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758678000615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678000616 S-adenosylmethionine binding site [chemical binding]; other site 758678000617 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758678000618 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 758678000619 ligand binding site [chemical binding]; other site 758678000620 flexible hinge region; other site 758678000621 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 758678000622 flagellin; Provisional; Region: PRK12804 758678000623 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758678000624 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 758678000625 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 758678000626 active site 758678000627 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 758678000628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678000629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000630 active site 758678000631 phosphorylation site [posttranslational modification] 758678000632 intermolecular recognition site; other site 758678000633 dimerization interface [polypeptide binding]; other site 758678000634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678000635 DNA binding site [nucleotide binding] 758678000636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000638 ATP binding site [chemical binding]; other site 758678000639 Mg2+ binding site [ion binding]; other site 758678000640 G-X-G motif; other site 758678000641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678000642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678000643 Walker A/P-loop; other site 758678000644 ATP binding site [chemical binding]; other site 758678000645 Q-loop/lid; other site 758678000646 ABC transporter signature motif; other site 758678000647 Walker B; other site 758678000648 D-loop; other site 758678000649 H-loop/switch region; other site 758678000650 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678000651 FtsX-like permease family; Region: FtsX; pfam02687 758678000652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758678000653 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 758678000654 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 758678000655 Malic enzyme, N-terminal domain; Region: malic; pfam00390 758678000656 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 758678000657 putative NAD(P) binding site [chemical binding]; other site 758678000658 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 758678000659 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 758678000660 PAS domain; Region: PAS; smart00091 758678000661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000662 ATP binding site [chemical binding]; other site 758678000663 Mg2+ binding site [ion binding]; other site 758678000664 G-X-G motif; other site 758678000665 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 758678000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000667 active site 758678000668 phosphorylation site [posttranslational modification] 758678000669 intermolecular recognition site; other site 758678000670 dimerization interface [polypeptide binding]; other site 758678000671 HTH domain; Region: HTH_11; cl17392 758678000672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678000673 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 758678000674 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 758678000675 trimer interface [polypeptide binding]; other site 758678000676 active site 758678000677 substrate binding site [chemical binding]; other site 758678000678 CoA binding site [chemical binding]; other site 758678000679 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678000680 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 758678000681 active site 758678000682 catalytic motif [active] 758678000683 Zn binding site [ion binding]; other site 758678000684 RibD C-terminal domain; Region: RibD_C; cl17279 758678000685 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 758678000686 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 758678000687 active site 758678000688 catalytic site [active] 758678000689 substrate binding site [chemical binding]; other site 758678000690 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 758678000691 Dimer interface [polypeptide binding]; other site 758678000692 Isochorismatase family; Region: Isochorismatase; pfam00857 758678000693 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758678000694 catalytic triad [active] 758678000695 conserved cis-peptide bond; other site 758678000696 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758678000697 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758678000698 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758678000699 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 758678000700 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758678000701 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758678000702 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758678000703 catalytic loop [active] 758678000704 iron binding site [ion binding]; other site 758678000705 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758678000706 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 758678000707 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 758678000708 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 758678000709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758678000710 catalytic residues [active] 758678000711 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 758678000712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000713 active site 758678000714 phosphorylation site [posttranslational modification] 758678000715 intermolecular recognition site; other site 758678000716 dimerization interface [polypeptide binding]; other site 758678000717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678000718 DNA binding site [nucleotide binding] 758678000719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000720 HAMP domain; Region: HAMP; pfam00672 758678000721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678000722 dimer interface [polypeptide binding]; other site 758678000723 phosphorylation site [posttranslational modification] 758678000724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000725 ATP binding site [chemical binding]; other site 758678000726 Mg2+ binding site [ion binding]; other site 758678000727 G-X-G motif; other site 758678000728 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758678000729 FAD binding domain; Region: FAD_binding_4; pfam01565 758678000730 Berberine and berberine like; Region: BBE; pfam08031 758678000731 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 758678000732 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678000733 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678000734 active site turn [active] 758678000735 phosphorylation site [posttranslational modification] 758678000736 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678000737 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678000738 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678000739 putative active site [active] 758678000740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678000741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678000742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678000743 putative active site [active] 758678000744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678000745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000746 active site 758678000747 phosphorylation site [posttranslational modification] 758678000748 intermolecular recognition site; other site 758678000749 dimerization interface [polypeptide binding]; other site 758678000750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678000751 DNA binding site [nucleotide binding] 758678000752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000753 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 758678000754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000755 ATP binding site [chemical binding]; other site 758678000756 Mg2+ binding site [ion binding]; other site 758678000757 G-X-G motif; other site 758678000758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678000759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678000760 Walker A/P-loop; other site 758678000761 ATP binding site [chemical binding]; other site 758678000762 Q-loop/lid; other site 758678000763 ABC transporter signature motif; other site 758678000764 Walker B; other site 758678000765 D-loop; other site 758678000766 H-loop/switch region; other site 758678000767 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 758678000768 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678000769 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678000770 active site turn [active] 758678000771 phosphorylation site [posttranslational modification] 758678000772 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 758678000773 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 758678000774 NAD binding site [chemical binding]; other site 758678000775 sugar binding site [chemical binding]; other site 758678000776 divalent metal binding site [ion binding]; other site 758678000777 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678000778 dimer interface [polypeptide binding]; other site 758678000779 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678000780 HPr interaction site; other site 758678000781 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678000782 active site 758678000783 phosphorylation site [posttranslational modification] 758678000784 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678000785 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678000786 putative active site [active] 758678000787 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758678000788 DNA-binding site [nucleotide binding]; DNA binding site 758678000789 RNA-binding motif; other site 758678000790 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 758678000791 Predicted transcriptional regulator [Transcription]; Region: COG1959 758678000792 Transcriptional regulator; Region: Rrf2; pfam02082 758678000793 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 758678000794 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 758678000795 catalytic residues [active] 758678000796 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 758678000797 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758678000798 NAD binding site [chemical binding]; other site 758678000799 substrate binding site [chemical binding]; other site 758678000800 putative active site [active] 758678000801 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678000802 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678000803 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678000804 putative active site [active] 758678000805 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 758678000806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678000807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678000808 active site turn [active] 758678000809 phosphorylation site [posttranslational modification] 758678000810 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 758678000811 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 758678000812 NAD binding site [chemical binding]; other site 758678000813 sugar binding site [chemical binding]; other site 758678000814 divalent metal binding site [ion binding]; other site 758678000815 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678000816 dimer interface [polypeptide binding]; other site 758678000817 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678000818 HPr interaction site; other site 758678000819 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678000820 active site 758678000821 phosphorylation site [posttranslational modification] 758678000822 Dehydratase family; Region: ILVD_EDD; pfam00920 758678000823 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 758678000824 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 758678000825 active site 758678000826 intersubunit interface [polypeptide binding]; other site 758678000827 catalytic residue [active] 758678000828 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758678000829 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 758678000830 substrate binding site [chemical binding]; other site 758678000831 ATP binding site [chemical binding]; other site 758678000832 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 758678000833 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758678000834 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 758678000835 active site 758678000836 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 758678000837 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678000838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000839 active site 758678000840 phosphorylation site [posttranslational modification] 758678000841 intermolecular recognition site; other site 758678000842 dimerization interface [polypeptide binding]; other site 758678000843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678000844 DNA binding site [nucleotide binding] 758678000845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678000847 dimerization interface [polypeptide binding]; other site 758678000848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678000849 dimer interface [polypeptide binding]; other site 758678000850 phosphorylation site [posttranslational modification] 758678000851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000852 ATP binding site [chemical binding]; other site 758678000853 Mg2+ binding site [ion binding]; other site 758678000854 G-X-G motif; other site 758678000855 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 758678000856 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 758678000857 Ligand binding site; other site 758678000858 Putative Catalytic site; other site 758678000859 DXD motif; other site 758678000860 Predicted membrane protein [Function unknown]; Region: COG2246 758678000861 GtrA-like protein; Region: GtrA; pfam04138 758678000862 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 758678000863 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 758678000864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678000865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678000866 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 758678000867 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678000868 intersubunit interface [polypeptide binding]; other site 758678000869 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758678000870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678000871 ABC-ATPase subunit interface; other site 758678000872 dimer interface [polypeptide binding]; other site 758678000873 putative PBP binding regions; other site 758678000874 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678000875 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678000876 Walker A/P-loop; other site 758678000877 ATP binding site [chemical binding]; other site 758678000878 Q-loop/lid; other site 758678000879 ABC transporter signature motif; other site 758678000880 Walker B; other site 758678000881 D-loop; other site 758678000882 H-loop/switch region; other site 758678000883 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678000884 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 758678000885 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758678000886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678000887 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678000888 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 758678000889 intersubunit interface [polypeptide binding]; other site 758678000890 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 758678000891 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678000892 intersubunit interface [polypeptide binding]; other site 758678000893 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 758678000894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678000895 ABC-ATPase subunit interface; other site 758678000896 dimer interface [polypeptide binding]; other site 758678000897 putative PBP binding regions; other site 758678000898 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758678000899 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678000900 ABC-ATPase subunit interface; other site 758678000901 dimer interface [polypeptide binding]; other site 758678000902 putative PBP binding regions; other site 758678000903 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678000904 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678000905 Walker A/P-loop; other site 758678000906 ATP binding site [chemical binding]; other site 758678000907 Q-loop/lid; other site 758678000908 ABC transporter signature motif; other site 758678000909 Walker B; other site 758678000910 D-loop; other site 758678000911 H-loop/switch region; other site 758678000912 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678000913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678000914 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 758678000915 Walker A/P-loop; other site 758678000916 ATP binding site [chemical binding]; other site 758678000917 Q-loop/lid; other site 758678000918 ABC transporter signature motif; other site 758678000919 Walker B; other site 758678000920 D-loop; other site 758678000921 H-loop/switch region; other site 758678000922 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 758678000923 xanthine permease; Region: pbuX; TIGR03173 758678000924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678000925 active site 758678000926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678000927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678000928 active site 758678000929 phosphorylation site [posttranslational modification] 758678000930 intermolecular recognition site; other site 758678000931 dimerization interface [polypeptide binding]; other site 758678000932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678000933 DNA binding site [nucleotide binding] 758678000934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 758678000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000937 ATP binding site [chemical binding]; other site 758678000938 Mg2+ binding site [ion binding]; other site 758678000939 G-X-G motif; other site 758678000940 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 758678000941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678000942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678000943 Walker A/P-loop; other site 758678000944 ATP binding site [chemical binding]; other site 758678000945 Q-loop/lid; other site 758678000946 ABC transporter signature motif; other site 758678000947 Walker B; other site 758678000948 D-loop; other site 758678000949 H-loop/switch region; other site 758678000950 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678000951 FtsX-like permease family; Region: FtsX; pfam02687 758678000952 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 758678000953 active site 758678000954 NTP binding site [chemical binding]; other site 758678000955 metal binding triad [ion binding]; metal-binding site 758678000956 antibiotic binding site [chemical binding]; other site 758678000957 Protein of unknown function DUF86; Region: DUF86; pfam01934 758678000958 LrgA family; Region: LrgA; pfam03788 758678000959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678000960 Radical SAM superfamily; Region: Radical_SAM; pfam04055 758678000961 FeS/SAM binding site; other site 758678000962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 758678000963 hypothetical protein; Provisional; Region: PRK13663 758678000964 Accessory gene regulator B; Region: AgrB; pfam04647 758678000965 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 758678000966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 758678000967 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678000968 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 758678000969 PAS domain S-box; Region: sensory_box; TIGR00229 758678000970 PAS domain; Region: PAS; smart00091 758678000971 putative active site [active] 758678000972 heme pocket [chemical binding]; other site 758678000973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678000975 dimer interface [polypeptide binding]; other site 758678000976 phosphorylation site [posttranslational modification] 758678000977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000978 ATP binding site [chemical binding]; other site 758678000979 Mg2+ binding site [ion binding]; other site 758678000980 G-X-G motif; other site 758678000981 Accessory gene regulator B; Region: AgrB; pfam04647 758678000982 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 758678000983 PAS domain S-box; Region: sensory_box; TIGR00229 758678000984 PAS domain; Region: PAS_8; pfam13188 758678000985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678000986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678000987 dimer interface [polypeptide binding]; other site 758678000988 phosphorylation site [posttranslational modification] 758678000989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678000990 ATP binding site [chemical binding]; other site 758678000991 Mg2+ binding site [ion binding]; other site 758678000992 G-X-G motif; other site 758678000993 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 758678000994 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 758678000995 Ligand Binding Site [chemical binding]; other site 758678000996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678000997 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 758678000998 non-specific DNA binding site [nucleotide binding]; other site 758678000999 salt bridge; other site 758678001000 sequence-specific DNA binding site [nucleotide binding]; other site 758678001001 Cupin domain; Region: Cupin_2; pfam07883 758678001002 Amino acid permease; Region: AA_permease_2; pfam13520 758678001003 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758678001004 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758678001005 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 758678001006 active site 758678001007 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 758678001008 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 758678001009 putative catalytic cysteine [active] 758678001010 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 758678001011 putative active site [active] 758678001012 metal binding site [ion binding]; metal-binding site 758678001013 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 758678001014 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 758678001015 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 758678001016 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 758678001017 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 758678001018 active site 758678001019 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 758678001020 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 758678001021 NodB motif; other site 758678001022 active site 758678001023 catalytic site [active] 758678001024 Zn binding site [ion binding]; other site 758678001025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001027 active site 758678001028 phosphorylation site [posttranslational modification] 758678001029 intermolecular recognition site; other site 758678001030 dimerization interface [polypeptide binding]; other site 758678001031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678001032 DNA binding site [nucleotide binding] 758678001033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678001034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678001035 dimerization interface [polypeptide binding]; other site 758678001036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678001037 dimer interface [polypeptide binding]; other site 758678001038 phosphorylation site [posttranslational modification] 758678001039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678001040 ATP binding site [chemical binding]; other site 758678001041 Mg2+ binding site [ion binding]; other site 758678001042 G-X-G motif; other site 758678001043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678001044 S-adenosylmethionine binding site [chemical binding]; other site 758678001045 Uncharacterized conserved protein [Function unknown]; Region: COG0398 758678001046 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758678001047 Putative amidase domain; Region: Amidase_6; pfam12671 758678001048 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678001049 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 758678001050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 758678001051 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758678001052 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758678001053 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 758678001054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758678001055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678001056 catalytic residue [active] 758678001057 Predicted membrane protein [Function unknown]; Region: COG2855 758678001058 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 758678001059 active site 758678001060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678001061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001062 intermolecular recognition site; other site 758678001063 active site 758678001064 dimerization interface [polypeptide binding]; other site 758678001065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678001066 DNA binding site [nucleotide binding] 758678001067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678001068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678001069 dimerization interface [polypeptide binding]; other site 758678001070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678001071 dimer interface [polypeptide binding]; other site 758678001072 phosphorylation site [posttranslational modification] 758678001073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678001074 ATP binding site [chemical binding]; other site 758678001075 Mg2+ binding site [ion binding]; other site 758678001076 G-X-G motif; other site 758678001077 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 758678001078 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 758678001079 Na binding site [ion binding]; other site 758678001080 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 758678001081 SLBB domain; Region: SLBB; pfam10531 758678001082 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678001083 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 758678001084 FMN-binding domain; Region: FMN_bind; cl01081 758678001085 electron transport complex RsxE subunit; Provisional; Region: PRK12405 758678001086 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 758678001087 potential frameshift: common BLAST hit: gi|237793693|ref|YP_002861245.1| ferredoxin 758678001088 ferredoxin; Validated; Region: PRK07118 758678001089 CheD chemotactic sensory transduction; Region: CheD; cl00810 758678001090 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758678001091 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 758678001092 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678001093 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001094 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001095 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001096 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 758678001097 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 758678001098 trimer interface [polypeptide binding]; other site 758678001099 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 758678001100 ApbE family; Region: ApbE; pfam02424 758678001101 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001102 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001103 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001104 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001105 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001106 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001107 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001108 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001109 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 758678001110 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 758678001111 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 758678001112 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 758678001113 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 758678001114 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 758678001115 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001116 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001117 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001118 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758678001119 Acyltransferase family; Region: Acyl_transf_3; pfam01757 758678001120 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758678001121 Bacterial Ig-like domain; Region: Big_5; pfam13205 758678001122 PBP superfamily domain; Region: PBP_like_2; cl17296 758678001123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678001124 dimer interface [polypeptide binding]; other site 758678001125 conserved gate region; other site 758678001126 putative PBP binding loops; other site 758678001127 ABC-ATPase subunit interface; other site 758678001128 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 758678001129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678001130 dimer interface [polypeptide binding]; other site 758678001131 conserved gate region; other site 758678001132 putative PBP binding loops; other site 758678001133 ABC-ATPase subunit interface; other site 758678001134 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 758678001135 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 758678001136 Walker A/P-loop; other site 758678001137 ATP binding site [chemical binding]; other site 758678001138 Q-loop/lid; other site 758678001139 ABC transporter signature motif; other site 758678001140 Walker B; other site 758678001141 D-loop; other site 758678001142 H-loop/switch region; other site 758678001143 Soluble P-type ATPase [General function prediction only]; Region: COG4087 758678001144 amino acid transporter; Region: 2A0306; TIGR00909 758678001145 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 758678001146 Protein of unknown function DUF45; Region: DUF45; pfam01863 758678001147 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 758678001148 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 758678001149 dimer interface [polypeptide binding]; other site 758678001150 ssDNA binding site [nucleotide binding]; other site 758678001151 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678001152 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758678001153 metal binding site 2 [ion binding]; metal-binding site 758678001154 putative DNA binding helix; other site 758678001155 metal binding site 1 [ion binding]; metal-binding site 758678001156 dimer interface [polypeptide binding]; other site 758678001157 structural Zn2+ binding site [ion binding]; other site 758678001158 Rhomboid family; Region: Rhomboid; pfam01694 758678001159 Cache domain; Region: Cache_1; pfam02743 758678001160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678001161 dimerization interface [polypeptide binding]; other site 758678001162 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678001163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678001164 dimer interface [polypeptide binding]; other site 758678001165 putative CheW interface [polypeptide binding]; other site 758678001166 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 758678001167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678001168 Walker A motif; other site 758678001169 ATP binding site [chemical binding]; other site 758678001170 Walker B motif; other site 758678001171 arginine finger; other site 758678001172 Peptidase family M41; Region: Peptidase_M41; pfam01434 758678001173 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 758678001174 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 758678001175 RNA/DNA hybrid binding site [nucleotide binding]; other site 758678001176 active site 758678001177 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678001178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001179 non-specific DNA binding site [nucleotide binding]; other site 758678001180 salt bridge; other site 758678001181 sequence-specific DNA binding site [nucleotide binding]; other site 758678001182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678001183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 758678001184 binding surface 758678001185 TPR motif; other site 758678001186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678001187 Helix-turn-helix domain; Region: HTH_19; pfam12844 758678001188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678001189 DJ-1 family protein; Region: not_thiJ; TIGR01383 758678001190 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 758678001191 conserved cys residue [active] 758678001192 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 758678001193 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 758678001194 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 758678001195 Clp amino terminal domain; Region: Clp_N; pfam02861 758678001196 Clp amino terminal domain; Region: Clp_N; pfam02861 758678001197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678001198 Walker A motif; other site 758678001199 ATP binding site [chemical binding]; other site 758678001200 Walker B motif; other site 758678001201 arginine finger; other site 758678001202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678001203 Walker A motif; other site 758678001204 ATP binding site [chemical binding]; other site 758678001205 Walker B motif; other site 758678001206 arginine finger; other site 758678001207 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 758678001208 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 758678001209 catalytic triad [active] 758678001210 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 758678001211 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678001212 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 758678001213 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 758678001214 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 758678001215 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 758678001216 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 758678001217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 758678001218 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758678001219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758678001220 putative acyl-acceptor binding pocket; other site 758678001221 aconitate hydratase; Validated; Region: PRK07229 758678001222 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 758678001223 substrate binding site [chemical binding]; other site 758678001224 ligand binding site [chemical binding]; other site 758678001225 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 758678001226 substrate binding site [chemical binding]; other site 758678001227 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 758678001228 tartrate dehydrogenase; Region: TTC; TIGR02089 758678001229 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758678001230 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758678001231 Walker A/P-loop; other site 758678001232 ATP binding site [chemical binding]; other site 758678001233 Q-loop/lid; other site 758678001234 ABC transporter signature motif; other site 758678001235 Walker B; other site 758678001236 D-loop; other site 758678001237 H-loop/switch region; other site 758678001238 Permease; Region: Permease; cl00510 758678001239 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 758678001240 Uncharacterized conserved protein [Function unknown]; Region: COG2155 758678001241 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 758678001242 tetramerization interface [polypeptide binding]; other site 758678001243 active site 758678001244 Pantoate-beta-alanine ligase; Region: PanC; cd00560 758678001245 pantoate--beta-alanine ligase; Region: panC; TIGR00018 758678001246 active site 758678001247 ATP-binding site [chemical binding]; other site 758678001248 pantoate-binding site; other site 758678001249 HXXH motif; other site 758678001250 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 758678001251 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 758678001252 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 758678001253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678001254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678001255 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678001256 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 758678001257 4Fe-4S binding domain; Region: Fer4; pfam00037 758678001258 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 758678001259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678001260 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 758678001261 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 758678001262 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 758678001263 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 758678001264 Family description; Region: UvrD_C_2; pfam13538 758678001265 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 758678001266 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758678001267 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678001268 dimer interface [polypeptide binding]; other site 758678001269 putative CheW interface [polypeptide binding]; other site 758678001270 peptidase T; Region: peptidase-T; TIGR01882 758678001271 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 758678001272 metal binding site [ion binding]; metal-binding site 758678001273 dimer interface [polypeptide binding]; other site 758678001274 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 758678001275 active site 758678001276 nucleophile elbow; other site 758678001277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678001278 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 758678001279 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758678001280 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001281 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001282 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678001283 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758678001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678001285 dimer interface [polypeptide binding]; other site 758678001286 conserved gate region; other site 758678001287 putative PBP binding loops; other site 758678001288 ABC-ATPase subunit interface; other site 758678001289 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758678001290 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758678001291 substrate binding pocket [chemical binding]; other site 758678001292 membrane-bound complex binding site; other site 758678001293 hinge residues; other site 758678001294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678001295 S-adenosylmethionine binding site [chemical binding]; other site 758678001296 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 758678001297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758678001298 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 758678001299 thiamine phosphate binding site [chemical binding]; other site 758678001300 active site 758678001301 pyrophosphate binding site [ion binding]; other site 758678001302 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 758678001303 substrate binding site [chemical binding]; other site 758678001304 multimerization interface [polypeptide binding]; other site 758678001305 ATP binding site [chemical binding]; other site 758678001306 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 758678001307 dimer interface [polypeptide binding]; other site 758678001308 substrate binding site [chemical binding]; other site 758678001309 ATP binding site [chemical binding]; other site 758678001310 Germination protease; Region: Peptidase_A25; cl04057 758678001311 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 758678001312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 758678001313 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758678001314 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758678001315 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758678001316 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758678001317 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758678001318 TM-ABC transporter signature motif; other site 758678001319 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758678001320 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758678001321 TM-ABC transporter signature motif; other site 758678001322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758678001323 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758678001324 Walker A/P-loop; other site 758678001325 ATP binding site [chemical binding]; other site 758678001326 Q-loop/lid; other site 758678001327 ABC transporter signature motif; other site 758678001328 Walker B; other site 758678001329 D-loop; other site 758678001330 H-loop/switch region; other site 758678001331 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758678001332 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758678001333 Walker A/P-loop; other site 758678001334 ATP binding site [chemical binding]; other site 758678001335 Q-loop/lid; other site 758678001336 ABC transporter signature motif; other site 758678001337 Walker B; other site 758678001338 D-loop; other site 758678001339 H-loop/switch region; other site 758678001340 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 758678001341 Uncharacterized conserved protein [Function unknown]; Region: COG2966 758678001342 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 758678001343 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 758678001344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678001345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678001346 DNA-binding site [nucleotide binding]; DNA binding site 758678001347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678001348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678001349 homodimer interface [polypeptide binding]; other site 758678001350 catalytic residue [active] 758678001351 LemA family; Region: LemA; pfam04011 758678001352 Repair protein; Region: Repair_PSII; pfam04536 758678001353 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 758678001354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758678001355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678001356 S-adenosylmethionine binding site [chemical binding]; other site 758678001357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001358 salt bridge; other site 758678001359 non-specific DNA binding site [nucleotide binding]; other site 758678001360 sequence-specific DNA binding site [nucleotide binding]; other site 758678001361 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 758678001362 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 758678001363 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 758678001364 active site 758678001365 metal binding site [ion binding]; metal-binding site 758678001366 DNA binding site [nucleotide binding] 758678001367 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 758678001368 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 758678001369 ADP-ribose binding site [chemical binding]; other site 758678001370 dimer interface [polypeptide binding]; other site 758678001371 active site 758678001372 nudix motif; other site 758678001373 metal binding site [ion binding]; metal-binding site 758678001374 Uncharacterized conserved protein [Function unknown]; Region: COG1284 758678001375 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 758678001376 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 758678001377 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 758678001378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678001379 dimerization interface [polypeptide binding]; other site 758678001380 putative DNA binding site [nucleotide binding]; other site 758678001381 putative Zn2+ binding site [ion binding]; other site 758678001382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 758678001383 Heavy-metal-associated domain; Region: HMA; pfam00403 758678001384 metal-binding site [ion binding] 758678001385 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678001386 Soluble P-type ATPase [General function prediction only]; Region: COG4087 758678001387 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 758678001388 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 758678001389 putative active site [active] 758678001390 PhoH-like protein; Region: PhoH; pfam02562 758678001391 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 758678001392 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 758678001393 NADPH bind site [chemical binding]; other site 758678001394 putative FMN binding site [chemical binding]; other site 758678001395 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 758678001396 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 758678001397 CAAX protease self-immunity; Region: Abi; pfam02517 758678001398 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678001399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001400 Walker A/P-loop; other site 758678001401 ATP binding site [chemical binding]; other site 758678001402 Q-loop/lid; other site 758678001403 ABC transporter signature motif; other site 758678001404 Walker B; other site 758678001405 D-loop; other site 758678001406 H-loop/switch region; other site 758678001407 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 758678001408 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758678001409 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758678001410 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758678001411 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758678001412 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 758678001413 Peptidase family M50; Region: Peptidase_M50; pfam02163 758678001414 active site 758678001415 putative substrate binding region [chemical binding]; other site 758678001416 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 758678001417 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 758678001418 transmembrane helices; other site 758678001419 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 758678001420 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 758678001421 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 758678001422 dimer interface [polypeptide binding]; other site 758678001423 catalytic triad [active] 758678001424 peroxidatic and resolving cysteines [active] 758678001425 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 758678001426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758678001427 NAD(P) binding site [chemical binding]; other site 758678001428 active site 758678001429 Response regulator receiver domain; Region: Response_reg; pfam00072 758678001430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001431 active site 758678001432 phosphorylation site [posttranslational modification] 758678001433 intermolecular recognition site; other site 758678001434 dimerization interface [polypeptide binding]; other site 758678001435 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 758678001436 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 758678001437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758678001438 PAS fold; Region: PAS_4; pfam08448 758678001439 Response regulator receiver domain; Region: Response_reg; pfam00072 758678001440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001441 active site 758678001442 phosphorylation site [posttranslational modification] 758678001443 intermolecular recognition site; other site 758678001444 dimerization interface [polypeptide binding]; other site 758678001445 Hpt domain; Region: Hpt; pfam01627 758678001446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678001447 Zn2+ binding site [ion binding]; other site 758678001448 Mg2+ binding site [ion binding]; other site 758678001449 Cache domain; Region: Cache_1; pfam02743 758678001450 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758678001451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758678001452 dimerization interface [polypeptide binding]; other site 758678001453 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678001454 dimer interface [polypeptide binding]; other site 758678001455 putative CheW interface [polypeptide binding]; other site 758678001456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001457 active site 758678001458 phosphorylation site [posttranslational modification] 758678001459 intermolecular recognition site; other site 758678001460 dimerization interface [polypeptide binding]; other site 758678001461 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 758678001462 seryl-tRNA synthetase; Provisional; Region: PRK05431 758678001463 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 758678001464 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 758678001465 motif 1; other site 758678001466 dimer interface [polypeptide binding]; other site 758678001467 active site 758678001468 motif 2; other site 758678001469 motif 3; other site 758678001470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 758678001471 DEAD_2; Region: DEAD_2; pfam06733 758678001472 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 758678001473 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 758678001474 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678001475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678001476 DNA-binding site [nucleotide binding]; DNA binding site 758678001477 TrkA-C domain; Region: TrkA_C; pfam02080 758678001478 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 758678001479 putative active site [active] 758678001480 putative ligand binding site [chemical binding]; other site 758678001481 putative NAD(P) binding site [chemical binding]; other site 758678001482 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 758678001483 Hemerythrin; Region: Hemerythrin; cd12107 758678001484 Fe binding site [ion binding]; other site 758678001485 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 758678001486 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 758678001487 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 758678001488 Amino acid permease; Region: AA_permease_2; pfam13520 758678001489 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 758678001490 AsnC family; Region: AsnC_trans_reg; pfam01037 758678001491 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 758678001492 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 758678001493 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 758678001494 Spore germination protein; Region: Spore_permease; cl17796 758678001495 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 758678001496 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 758678001497 trimer interface [polypeptide binding]; other site 758678001498 putative metal binding site [ion binding]; other site 758678001499 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 758678001500 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 758678001501 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 758678001502 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678001503 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 758678001504 Soluble P-type ATPase [General function prediction only]; Region: COG4087 758678001505 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 758678001506 Chromate transporter; Region: Chromate_transp; pfam02417 758678001507 Chromate transporter; Region: Chromate_transp; pfam02417 758678001508 PemK-like protein; Region: PemK; pfam02452 758678001509 Protein of unknown function (DUF327); Region: DUF327; pfam03885 758678001510 NAD synthetase; Reviewed; Region: nadE; PRK02628 758678001511 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 758678001512 multimer interface [polypeptide binding]; other site 758678001513 active site 758678001514 catalytic triad [active] 758678001515 protein interface 1 [polypeptide binding]; other site 758678001516 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 758678001517 homodimer interface [polypeptide binding]; other site 758678001518 NAD binding pocket [chemical binding]; other site 758678001519 ATP binding pocket [chemical binding]; other site 758678001520 Mg binding site [ion binding]; other site 758678001521 active-site loop [active] 758678001522 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 758678001523 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 758678001524 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 758678001525 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 758678001526 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758678001527 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 758678001528 active site 758678001529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001530 non-specific DNA binding site [nucleotide binding]; other site 758678001531 salt bridge; other site 758678001532 sequence-specific DNA binding site [nucleotide binding]; other site 758678001533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678001534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678001535 Coenzyme A binding pocket [chemical binding]; other site 758678001536 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 758678001537 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 758678001538 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758678001539 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 758678001540 Carbon starvation protein CstA; Region: CstA; pfam02554 758678001541 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 758678001542 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 758678001543 Cache domain; Region: Cache_1; pfam02743 758678001544 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678001545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678001546 dimer interface [polypeptide binding]; other site 758678001547 putative CheW interface [polypeptide binding]; other site 758678001548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678001549 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 758678001550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678001551 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 758678001552 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 758678001553 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 758678001554 SEC-C motif; Region: SEC-C; pfam02810 758678001555 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678001556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678001557 DNA-binding site [nucleotide binding]; DNA binding site 758678001558 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 758678001559 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678001560 Walker A/P-loop; other site 758678001561 ATP binding site [chemical binding]; other site 758678001562 Q-loop/lid; other site 758678001563 ABC transporter signature motif; other site 758678001564 Walker B; other site 758678001565 D-loop; other site 758678001566 H-loop/switch region; other site 758678001567 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758678001568 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 758678001569 Walker A/P-loop; other site 758678001570 ATP binding site [chemical binding]; other site 758678001571 Q-loop/lid; other site 758678001572 ABC transporter signature motif; other site 758678001573 Walker B; other site 758678001574 D-loop; other site 758678001575 H-loop/switch region; other site 758678001576 TOBE domain; Region: TOBE_2; pfam08402 758678001577 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 758678001578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678001579 dimer interface [polypeptide binding]; other site 758678001580 conserved gate region; other site 758678001581 putative PBP binding loops; other site 758678001582 ABC-ATPase subunit interface; other site 758678001583 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758678001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678001585 dimer interface [polypeptide binding]; other site 758678001586 conserved gate region; other site 758678001587 putative PBP binding loops; other site 758678001588 ABC-ATPase subunit interface; other site 758678001589 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 758678001590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758678001591 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758678001592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678001593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001594 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758678001595 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 758678001596 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 758678001597 Short C-terminal domain; Region: SHOCT; pfam09851 758678001598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678001599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678001600 Coenzyme A binding pocket [chemical binding]; other site 758678001601 CAAX protease self-immunity; Region: Abi; pfam02517 758678001602 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 758678001603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758678001604 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 758678001605 putative tRNA-binding site [nucleotide binding]; other site 758678001606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001607 non-specific DNA binding site [nucleotide binding]; other site 758678001608 salt bridge; other site 758678001609 sequence-specific DNA binding site [nucleotide binding]; other site 758678001610 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 758678001611 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 758678001612 Catalytic site [active] 758678001613 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 758678001614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001615 active site 758678001616 phosphorylation site [posttranslational modification] 758678001617 intermolecular recognition site; other site 758678001618 dimerization interface [polypeptide binding]; other site 758678001619 LytTr DNA-binding domain; Region: LytTR; smart00850 758678001620 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 758678001621 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 758678001622 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 758678001623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678001624 FeS/SAM binding site; other site 758678001625 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 758678001626 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 758678001627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678001628 Coenzyme A binding pocket [chemical binding]; other site 758678001629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678001630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678001631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001632 Walker A/P-loop; other site 758678001633 ATP binding site [chemical binding]; other site 758678001634 Q-loop/lid; other site 758678001635 ABC transporter signature motif; other site 758678001636 Walker B; other site 758678001637 D-loop; other site 758678001638 H-loop/switch region; other site 758678001639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758678001640 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 758678001641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678001642 FtsX-like permease family; Region: FtsX; pfam02687 758678001643 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678001644 FtsX-like permease family; Region: FtsX; pfam02687 758678001645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678001646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678001647 Walker A/P-loop; other site 758678001648 ATP binding site [chemical binding]; other site 758678001649 Q-loop/lid; other site 758678001650 ABC transporter signature motif; other site 758678001651 Walker B; other site 758678001652 D-loop; other site 758678001653 H-loop/switch region; other site 758678001654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678001655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678001656 Coenzyme A binding pocket [chemical binding]; other site 758678001657 EDD domain protein, DegV family; Region: DegV; TIGR00762 758678001658 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 758678001659 hypothetical protein; Provisional; Region: PRK04164 758678001660 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 758678001661 EamA-like transporter family; Region: EamA; cl17759 758678001662 Sulfatase; Region: Sulfatase; pfam00884 758678001663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678001664 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758678001665 Walker A motif; other site 758678001666 ATP binding site [chemical binding]; other site 758678001667 Walker B motif; other site 758678001668 arginine finger; other site 758678001669 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758678001670 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 758678001671 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 758678001672 Nucleoside recognition; Region: Gate; pfam07670 758678001673 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 758678001674 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 758678001675 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 758678001676 putative dimer interface [polypeptide binding]; other site 758678001677 putative anticodon binding site; other site 758678001678 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 758678001679 homodimer interface [polypeptide binding]; other site 758678001680 motif 1; other site 758678001681 motif 2; other site 758678001682 active site 758678001683 motif 3; other site 758678001684 Predicted transcriptional regulators [Transcription]; Region: COG1695 758678001685 Transcriptional regulator PadR-like family; Region: PadR; cl17335 758678001686 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 758678001687 LytTr DNA-binding domain; Region: LytTR; smart00850 758678001688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678001690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 758678001692 CAAX protease self-immunity; Region: Abi; pfam02517 758678001693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678001694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001695 non-specific DNA binding site [nucleotide binding]; other site 758678001696 salt bridge; other site 758678001697 sequence-specific DNA binding site [nucleotide binding]; other site 758678001698 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 758678001699 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 758678001700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678001701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001702 active site 758678001703 phosphorylation site [posttranslational modification] 758678001704 intermolecular recognition site; other site 758678001705 dimerization interface [polypeptide binding]; other site 758678001706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678001707 DNA binding site [nucleotide binding] 758678001708 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 758678001709 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 758678001710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001712 active site 758678001713 phosphorylation site [posttranslational modification] 758678001714 intermolecular recognition site; other site 758678001715 dimerization interface [polypeptide binding]; other site 758678001716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678001717 DNA binding site [nucleotide binding] 758678001718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678001719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678001720 dimer interface [polypeptide binding]; other site 758678001721 phosphorylation site [posttranslational modification] 758678001722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678001723 ATP binding site [chemical binding]; other site 758678001724 Mg2+ binding site [ion binding]; other site 758678001725 G-X-G motif; other site 758678001726 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 758678001727 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 758678001728 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678001729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001730 active site 758678001731 phosphorylation site [posttranslational modification] 758678001732 intermolecular recognition site; other site 758678001733 dimerization interface [polypeptide binding]; other site 758678001734 YcbB domain; Region: YcbB; pfam08664 758678001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678001736 ATP binding site [chemical binding]; other site 758678001737 Mg2+ binding site [ion binding]; other site 758678001738 G-X-G motif; other site 758678001739 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 758678001740 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 758678001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758678001742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678001743 S-adenosylmethionine binding site [chemical binding]; other site 758678001744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678001745 dimerization interface [polypeptide binding]; other site 758678001746 putative Zn2+ binding site [ion binding]; other site 758678001747 putative DNA binding site [nucleotide binding]; other site 758678001748 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678001749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678001750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001751 Walker A/P-loop; other site 758678001752 ATP binding site [chemical binding]; other site 758678001753 Q-loop/lid; other site 758678001754 ABC transporter signature motif; other site 758678001755 Walker B; other site 758678001756 D-loop; other site 758678001757 H-loop/switch region; other site 758678001758 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 758678001759 Chloramphenicol acetyltransferase; Region: CAT; smart01059 758678001760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678001761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678001762 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678001763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678001764 Coenzyme A binding pocket [chemical binding]; other site 758678001765 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 758678001766 dimer interface [polypeptide binding]; other site 758678001767 putative tRNA-binding site [nucleotide binding]; other site 758678001768 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758678001769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678001770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678001772 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 758678001773 non-specific DNA binding site [nucleotide binding]; other site 758678001774 salt bridge; other site 758678001775 sequence-specific DNA binding site [nucleotide binding]; other site 758678001776 Cupin domain; Region: Cupin_2; pfam07883 758678001777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 758678001778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001779 Q-loop/lid; other site 758678001780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678001781 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678001782 Walker A/P-loop; other site 758678001783 ATP binding site [chemical binding]; other site 758678001784 Q-loop/lid; other site 758678001785 ABC transporter signature motif; other site 758678001786 Walker B; other site 758678001787 D-loop; other site 758678001788 H-loop/switch region; other site 758678001789 potential frameshift: common BLAST hit: gi|237793943|ref|YP_002861495.1| ABC transporter permease 758678001790 allantoate amidohydrolase; Reviewed; Region: PRK09290 758678001791 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 758678001792 active site 758678001793 metal binding site [ion binding]; metal-binding site 758678001794 dimer interface [polypeptide binding]; other site 758678001795 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 758678001796 MutS domain III; Region: MutS_III; pfam05192 758678001797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001798 Walker A/P-loop; other site 758678001799 ATP binding site [chemical binding]; other site 758678001800 Q-loop/lid; other site 758678001801 ABC transporter signature motif; other site 758678001802 Walker B; other site 758678001803 D-loop; other site 758678001804 H-loop/switch region; other site 758678001805 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 758678001806 Protein of unknown function (DUF454); Region: DUF454; cl01063 758678001807 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 758678001808 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC; Region: monoFe_hyd_HmdC; TIGR03958 758678001809 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678001810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678001811 DNA-binding site [nucleotide binding]; DNA binding site 758678001812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678001814 homodimer interface [polypeptide binding]; other site 758678001815 catalytic residue [active] 758678001816 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 758678001817 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758678001818 ATP binding site [chemical binding]; other site 758678001819 Mg++ binding site [ion binding]; other site 758678001820 motif III; other site 758678001821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678001822 nucleotide binding region [chemical binding]; other site 758678001823 ATP-binding site [chemical binding]; other site 758678001824 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 758678001825 diiron binding motif [ion binding]; other site 758678001826 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678001827 MarR family; Region: MarR_2; pfam12802 758678001828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678001829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758678001830 putative substrate translocation pore; other site 758678001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678001832 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 758678001833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001834 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 758678001835 Walker A/P-loop; other site 758678001836 ATP binding site [chemical binding]; other site 758678001837 Q-loop/lid; other site 758678001838 ABC transporter signature motif; other site 758678001839 Walker B; other site 758678001840 D-loop; other site 758678001841 H-loop/switch region; other site 758678001842 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758678001843 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758678001844 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 758678001845 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 758678001846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758678001847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678001848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758678001849 dimerization interface [polypeptide binding]; other site 758678001850 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 758678001851 transcriptional antiterminator BglG; Provisional; Region: PRK09772 758678001852 CAT RNA binding domain; Region: CAT_RBD; smart01061 758678001853 PRD domain; Region: PRD; pfam00874 758678001854 PRD domain; Region: PRD; pfam00874 758678001855 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 758678001856 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678001857 active site turn [active] 758678001858 phosphorylation site [posttranslational modification] 758678001859 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678001860 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678001861 HPr interaction site; other site 758678001862 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678001863 active site 758678001864 phosphorylation site [posttranslational modification] 758678001865 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 758678001866 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 758678001867 active site 758678001868 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 758678001869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758678001870 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678001871 ligand binding site [chemical binding]; other site 758678001872 flexible hinge region; other site 758678001873 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758678001874 putative switch regulator; other site 758678001875 non-specific DNA interactions [nucleotide binding]; other site 758678001876 DNA binding site [nucleotide binding] 758678001877 sequence specific DNA binding site [nucleotide binding]; other site 758678001878 putative cAMP binding site [chemical binding]; other site 758678001879 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 758678001880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678001881 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678001882 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 758678001883 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 758678001884 Family of unknown function (DUF438); Region: DUF438; pfam04282 758678001885 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 758678001886 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 758678001887 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678001888 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 758678001889 TM-ABC transporter signature motif; other site 758678001890 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 758678001891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678001892 Walker A/P-loop; other site 758678001893 ATP binding site [chemical binding]; other site 758678001894 Q-loop/lid; other site 758678001895 ABC transporter signature motif; other site 758678001896 Walker B; other site 758678001897 D-loop; other site 758678001898 H-loop/switch region; other site 758678001899 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 758678001900 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758678001901 zinc binding site [ion binding]; other site 758678001902 putative ligand binding site [chemical binding]; other site 758678001903 Penicillinase repressor; Region: Pencillinase_R; pfam03965 758678001904 RNA polymerase factor sigma-70; Validated; Region: PRK06811 758678001905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678001906 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 758678001907 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 758678001908 FMN binding site [chemical binding]; other site 758678001909 active site 758678001910 catalytic residues [active] 758678001911 substrate binding site [chemical binding]; other site 758678001912 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 758678001913 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 758678001914 Outer spore coat protein E (CotE); Region: CotE; pfam10628 758678001915 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678001916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001917 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 758678001918 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678001919 intersubunit interface [polypeptide binding]; other site 758678001920 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758678001921 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678001922 ABC-ATPase subunit interface; other site 758678001923 dimer interface [polypeptide binding]; other site 758678001924 putative PBP binding regions; other site 758678001925 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678001926 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678001927 Walker A/P-loop; other site 758678001928 ATP binding site [chemical binding]; other site 758678001929 Q-loop/lid; other site 758678001930 ABC transporter signature motif; other site 758678001931 Walker B; other site 758678001932 D-loop; other site 758678001933 H-loop/switch region; other site 758678001934 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678001935 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 758678001936 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 758678001937 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 758678001938 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 758678001939 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 758678001940 Cache domain; Region: Cache_1; pfam02743 758678001941 HAMP domain; Region: HAMP; pfam00672 758678001942 dimerization interface [polypeptide binding]; other site 758678001943 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678001944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678001945 dimer interface [polypeptide binding]; other site 758678001946 putative CheW interface [polypeptide binding]; other site 758678001947 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 758678001948 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 758678001949 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 758678001950 glycine cleavage system protein H; Provisional; Region: PRK13380 758678001951 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 758678001952 lipoyl attachment site [posttranslational modification]; other site 758678001953 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 758678001954 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 758678001955 tetramer interface [polypeptide binding]; other site 758678001956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678001957 catalytic residue [active] 758678001958 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 758678001959 tetramer interface [polypeptide binding]; other site 758678001960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678001961 catalytic residue [active] 758678001962 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 758678001963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678001964 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758678001965 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 758678001966 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 758678001967 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 758678001968 Restriction endonuclease; Region: Mrr_cat; pfam04471 758678001969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 758678001970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001971 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678001972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678001973 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 758678001974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 758678001975 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678001976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678001977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678001978 active site 758678001979 phosphorylation site [posttranslational modification] 758678001980 intermolecular recognition site; other site 758678001981 dimerization interface [polypeptide binding]; other site 758678001982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678001983 DNA binding site [nucleotide binding] 758678001984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678001985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678001986 dimer interface [polypeptide binding]; other site 758678001987 phosphorylation site [posttranslational modification] 758678001988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678001989 ATP binding site [chemical binding]; other site 758678001990 Mg2+ binding site [ion binding]; other site 758678001991 G-X-G motif; other site 758678001992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678001993 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678001994 Walker A/P-loop; other site 758678001995 ATP binding site [chemical binding]; other site 758678001996 Q-loop/lid; other site 758678001997 ABC transporter signature motif; other site 758678001998 Walker B; other site 758678001999 D-loop; other site 758678002000 H-loop/switch region; other site 758678002001 FtsX-like permease family; Region: FtsX; pfam02687 758678002002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678002003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678002004 FtsX-like permease family; Region: FtsX; pfam02687 758678002005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678002006 MarR family; Region: MarR; pfam01047 758678002007 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678002008 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678002009 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 758678002010 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 758678002011 DNA binding residues [nucleotide binding] 758678002012 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 758678002013 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002014 DNA binding residues [nucleotide binding] 758678002015 dimer interface [polypeptide binding]; other site 758678002016 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 758678002017 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 758678002018 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 758678002019 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 758678002020 active site 758678002021 myosin-cross-reactive antigen; Provisional; Region: PRK13977 758678002022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678002023 Walker A/P-loop; other site 758678002024 ATP binding site [chemical binding]; other site 758678002025 Q-loop/lid; other site 758678002026 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678002027 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678002028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 758678002029 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 758678002030 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678002031 Walker A/P-loop; other site 758678002032 ATP binding site [chemical binding]; other site 758678002033 Q-loop/lid; other site 758678002034 ABC transporter signature motif; other site 758678002035 Walker B; other site 758678002036 D-loop; other site 758678002037 H-loop/switch region; other site 758678002038 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758678002039 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758678002040 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758678002041 EamA-like transporter family; Region: EamA; pfam00892 758678002042 EamA-like transporter family; Region: EamA; pfam00892 758678002043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678002044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002045 non-specific DNA binding site [nucleotide binding]; other site 758678002046 salt bridge; other site 758678002047 sequence-specific DNA binding site [nucleotide binding]; other site 758678002048 Cupin domain; Region: Cupin_2; pfam07883 758678002049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002050 Coenzyme A binding pocket [chemical binding]; other site 758678002051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678002052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002053 TfoX C-terminal domain; Region: TfoX_C; pfam04994 758678002054 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 758678002055 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 758678002056 active site 758678002057 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 758678002058 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678002059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678002060 dimer interface [polypeptide binding]; other site 758678002061 putative CheW interface [polypeptide binding]; other site 758678002062 Mor transcription activator family; Region: Mor; cl02360 758678002063 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 758678002064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678002065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678002066 ABC transporter; Region: ABC_tran_2; pfam12848 758678002067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678002068 Predicted transcriptional regulator [Transcription]; Region: COG2378 758678002069 HTH domain; Region: HTH_11; pfam08279 758678002070 WYL domain; Region: WYL; pfam13280 758678002071 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 758678002072 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758678002073 conserved cys residue [active] 758678002074 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 758678002075 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 758678002076 dimer interface [polypeptide binding]; other site 758678002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002078 catalytic residue [active] 758678002079 S-ribosylhomocysteinase; Provisional; Region: PRK02260 758678002080 cystathionine beta-lyase; Provisional; Region: PRK07671 758678002081 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 758678002082 homodimer interface [polypeptide binding]; other site 758678002083 substrate-cofactor binding pocket; other site 758678002084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002085 catalytic residue [active] 758678002086 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758678002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678002088 S-adenosylmethionine binding site [chemical binding]; other site 758678002089 Glyco_18 domain; Region: Glyco_18; smart00636 758678002090 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 758678002091 active site 758678002092 Chitinase C; Region: ChiC; pfam06483 758678002093 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678002094 metal-binding site [ion binding] 758678002095 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 758678002096 Domain of unknown function (DUF955); Region: DUF955; pfam06114 758678002097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678002098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002099 non-specific DNA binding site [nucleotide binding]; other site 758678002100 salt bridge; other site 758678002101 sequence-specific DNA binding site [nucleotide binding]; other site 758678002102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002103 non-specific DNA binding site [nucleotide binding]; other site 758678002104 salt bridge; other site 758678002105 sequence-specific DNA binding site [nucleotide binding]; other site 758678002106 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 758678002107 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678002108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678002109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 758678002110 DNA binding residues [nucleotide binding] 758678002111 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 758678002112 active site 758678002113 metal binding site [ion binding]; metal-binding site 758678002114 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 758678002115 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 758678002116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678002117 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 758678002118 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 758678002119 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 758678002120 Low molecular weight phosphatase family; Region: LMWPc; cl00105 758678002121 active site 758678002122 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 758678002123 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 758678002124 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 758678002125 P loop; other site 758678002126 Nucleotide binding site [chemical binding]; other site 758678002127 DTAP/Switch II; other site 758678002128 Switch I; other site 758678002129 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 758678002130 P loop; other site 758678002131 Nucleotide binding site [chemical binding]; other site 758678002132 DTAP/Switch II; other site 758678002133 Switch I; other site 758678002134 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 758678002135 arsenical-resistance protein; Region: acr3; TIGR00832 758678002136 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 758678002137 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 758678002138 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678002139 dimerization interface [polypeptide binding]; other site 758678002140 putative DNA binding site [nucleotide binding]; other site 758678002141 putative Zn2+ binding site [ion binding]; other site 758678002142 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 758678002143 catalytic core [active] 758678002144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002145 sequence-specific DNA binding site [nucleotide binding]; other site 758678002146 salt bridge; other site 758678002147 Low molecular weight phosphatase family; Region: LMWPc; cl00105 758678002148 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 758678002149 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 758678002150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 758678002151 DNA binding residues [nucleotide binding] 758678002152 Clostridium P-47 protein; Region: Clostridium_P47; pfam06597 758678002153 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 758678002154 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 758678002155 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 758678002156 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 758678002157 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 758678002158 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 758678002159 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 758678002160 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 758678002161 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 758678002162 active site 758678002163 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678002164 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 758678002165 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 758678002166 dimerization interface [polypeptide binding]; other site 758678002167 active site 758678002168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678002169 S-adenosylmethionine binding site [chemical binding]; other site 758678002170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758678002171 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 758678002172 dimer interface [polypeptide binding]; other site 758678002173 substrate binding site [chemical binding]; other site 758678002174 ATP binding site [chemical binding]; other site 758678002175 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 758678002176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678002177 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678002178 Walker A/P-loop; other site 758678002179 ATP binding site [chemical binding]; other site 758678002180 Q-loop/lid; other site 758678002181 ABC transporter signature motif; other site 758678002182 Walker B; other site 758678002183 D-loop; other site 758678002184 H-loop/switch region; other site 758678002185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002187 active site 758678002188 phosphorylation site [posttranslational modification] 758678002189 intermolecular recognition site; other site 758678002190 dimerization interface [polypeptide binding]; other site 758678002191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002192 DNA binding site [nucleotide binding] 758678002193 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678002194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678002195 Walker A/P-loop; other site 758678002196 ATP binding site [chemical binding]; other site 758678002197 Q-loop/lid; other site 758678002198 ABC transporter signature motif; other site 758678002199 Walker B; other site 758678002200 D-loop; other site 758678002201 H-loop/switch region; other site 758678002202 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 758678002203 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678002204 Helix-turn-helix domain; Region: HTH_18; pfam12833 758678002205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002206 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 758678002207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678002208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002209 dimer interface [polypeptide binding]; other site 758678002210 phosphorylation site [posttranslational modification] 758678002211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002212 ATP binding site [chemical binding]; other site 758678002213 Mg2+ binding site [ion binding]; other site 758678002214 G-X-G motif; other site 758678002215 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 758678002216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678002217 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678002218 Walker A/P-loop; other site 758678002219 ATP binding site [chemical binding]; other site 758678002220 Q-loop/lid; other site 758678002221 ABC transporter signature motif; other site 758678002222 Walker B; other site 758678002223 D-loop; other site 758678002224 H-loop/switch region; other site 758678002225 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678002226 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678002227 FtsX-like permease family; Region: FtsX; pfam02687 758678002228 FtsX-like permease family; Region: FtsX; pfam02687 758678002229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002231 active site 758678002232 phosphorylation site [posttranslational modification] 758678002233 intermolecular recognition site; other site 758678002234 dimerization interface [polypeptide binding]; other site 758678002235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002236 DNA binding site [nucleotide binding] 758678002237 potential frameshift: common BLAST hit: gi|153938620|ref|YP_001390145.1| sensor histidine kinase 758678002238 potential frameshift: common BLAST hit: gi|153938620|ref|YP_001390145.1| sensor histidine kinase 758678002239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002241 ATP binding site [chemical binding]; other site 758678002242 Mg2+ binding site [ion binding]; other site 758678002243 G-X-G motif; other site 758678002244 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 758678002245 Small acid-soluble spore protein H family; Region: SspH; pfam08141 758678002246 dihydrodipicolinate reductase; Provisional; Region: PRK00048 758678002247 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 758678002248 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 758678002249 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 758678002250 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 758678002251 active site residue [active] 758678002252 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 758678002253 active site residue [active] 758678002254 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 758678002255 SIR2-like domain; Region: SIR2_2; pfam13289 758678002256 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758678002257 active site 758678002258 Int/Topo IB signature motif; other site 758678002259 DNA binding site [nucleotide binding] 758678002260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758678002261 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 758678002262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 758678002263 Beta-lactamase; Region: Beta-lactamase; pfam00144 758678002264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678002265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002266 non-specific DNA binding site [nucleotide binding]; other site 758678002267 salt bridge; other site 758678002268 sequence-specific DNA binding site [nucleotide binding]; other site 758678002269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 758678002270 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 758678002271 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 758678002272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758678002273 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 758678002274 active site 758678002275 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 758678002276 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 758678002277 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678002278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678002279 dimer interface [polypeptide binding]; other site 758678002280 putative CheW interface [polypeptide binding]; other site 758678002281 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 758678002282 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 758678002283 FeoA domain; Region: FeoA; pfam04023 758678002284 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 758678002285 GTP/Mg2+ binding site [chemical binding]; other site 758678002286 G5 box; other site 758678002287 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 758678002288 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 758678002289 G1 box; other site 758678002290 G1 box; other site 758678002291 GTP/Mg2+ binding site [chemical binding]; other site 758678002292 Switch I region; other site 758678002293 G2 box; other site 758678002294 G3 box; other site 758678002295 Switch II region; other site 758678002296 G4 box; other site 758678002297 G5 box; other site 758678002298 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 758678002299 Nucleoside recognition; Region: Gate; pfam07670 758678002300 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 758678002301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758678002302 catalytic core [active] 758678002303 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 758678002304 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 758678002305 VanW like protein; Region: VanW; pfam04294 758678002306 G5 domain; Region: G5; pfam07501 758678002307 cobalamin synthase; Reviewed; Region: cobS; PRK00235 758678002308 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 758678002309 Coat F domain; Region: Coat_F; pfam07875 758678002310 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 758678002311 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 758678002312 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 758678002313 NodB motif; other site 758678002314 putative active site [active] 758678002315 putative catalytic site [active] 758678002316 putative Zn binding site [ion binding]; other site 758678002317 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 758678002318 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 758678002319 active site 758678002320 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 758678002321 dihydropteroate synthase; Region: DHPS; TIGR01496 758678002322 substrate binding pocket [chemical binding]; other site 758678002323 dimer interface [polypeptide binding]; other site 758678002324 inhibitor binding site; inhibition site 758678002325 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 758678002326 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 758678002327 catalytic center binding site [active] 758678002328 ATP binding site [chemical binding]; other site 758678002329 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 758678002330 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 758678002331 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 758678002332 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002333 DNA binding residues [nucleotide binding] 758678002334 dimer interface [polypeptide binding]; other site 758678002335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678002336 S-adenosylmethionine binding site [chemical binding]; other site 758678002337 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 758678002338 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 758678002339 inhibitor-cofactor binding pocket; inhibition site 758678002340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002341 catalytic residue [active] 758678002342 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 758678002343 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 758678002344 inhibitor-cofactor binding pocket; inhibition site 758678002345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002346 catalytic residue [active] 758678002347 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 758678002348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678002349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678002350 DNA binding residues [nucleotide binding] 758678002351 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 758678002352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758678002353 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 758678002354 Protein of unknown function (DUF523); Region: DUF523; pfam04463 758678002355 Uncharacterized conserved protein [Function unknown]; Region: COG2128 758678002356 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758678002357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678002358 putative DNA binding site [nucleotide binding]; other site 758678002359 putative Zn2+ binding site [ion binding]; other site 758678002360 AsnC family; Region: AsnC_trans_reg; pfam01037 758678002361 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 758678002362 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 758678002363 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678002364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678002365 Walker A/P-loop; other site 758678002366 ATP binding site [chemical binding]; other site 758678002367 Q-loop/lid; other site 758678002368 ABC transporter signature motif; other site 758678002369 Walker B; other site 758678002370 D-loop; other site 758678002371 H-loop/switch region; other site 758678002372 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678002373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758678002374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758678002375 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 758678002376 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758678002377 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 758678002378 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 758678002379 DNA binding residues [nucleotide binding] 758678002380 dimer interface [polypeptide binding]; other site 758678002381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002382 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678002383 Coenzyme A binding pocket [chemical binding]; other site 758678002384 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 758678002385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002386 Coenzyme A binding pocket [chemical binding]; other site 758678002387 Pirin-related protein [General function prediction only]; Region: COG1741 758678002388 Pirin; Region: Pirin; pfam02678 758678002389 Predicted transcriptional regulators [Transcription]; Region: COG1733 758678002390 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 758678002391 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 758678002392 dimer interface [polypeptide binding]; other site 758678002393 FMN binding site [chemical binding]; other site 758678002394 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 758678002395 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 758678002396 Cupin; Region: Cupin_1; smart00835 758678002397 Cupin; Region: Cupin_1; smart00835 758678002398 TIGR00730 family protein; Region: TIGR00730 758678002399 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678002400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758678002401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678002402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758678002403 dimerization interface [polypeptide binding]; other site 758678002404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678002405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002406 Coenzyme A binding pocket [chemical binding]; other site 758678002407 dUMP phosphatase; Provisional; Region: PRK09449 758678002408 dUMP phosphatase; Provisional; Region: PRK09449 758678002409 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678002410 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678002411 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 758678002412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678002413 ligand binding site [chemical binding]; other site 758678002414 flexible hinge region; other site 758678002415 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758678002416 putative switch regulator; other site 758678002417 DNA binding site [nucleotide binding] 758678002418 sequence specific DNA binding site [nucleotide binding]; other site 758678002419 putative cAMP binding site [chemical binding]; other site 758678002420 Predicted transcriptional regulator [Transcription]; Region: COG2378 758678002421 HTH domain; Region: HTH_11; pfam08279 758678002422 WYL domain; Region: WYL; pfam13280 758678002423 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 758678002424 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 758678002425 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 758678002426 DNA binding residues [nucleotide binding] 758678002427 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758678002428 active site 758678002429 catalytic residues [active] 758678002430 metal binding site [ion binding]; metal-binding site 758678002431 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678002432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678002433 DNA-binding site [nucleotide binding]; DNA binding site 758678002434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678002435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002436 homodimer interface [polypeptide binding]; other site 758678002437 catalytic residue [active] 758678002438 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 758678002439 putative FMN binding site [chemical binding]; other site 758678002440 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 758678002441 transcriptional antiterminator BglG; Provisional; Region: PRK09772 758678002442 CAT RNA binding domain; Region: CAT_RBD; smart01061 758678002443 PRD domain; Region: PRD; pfam00874 758678002444 PRD domain; Region: PRD; pfam00874 758678002445 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 758678002446 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678002447 active site turn [active] 758678002448 phosphorylation site [posttranslational modification] 758678002449 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678002450 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678002451 HPr interaction site; other site 758678002452 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678002453 active site 758678002454 phosphorylation site [posttranslational modification] 758678002455 beta-galactosidase; Region: BGL; TIGR03356 758678002456 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 758678002457 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 758678002458 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 758678002459 Mg++ binding site [ion binding]; other site 758678002460 putative catalytic motif [active] 758678002461 putative substrate binding site [chemical binding]; other site 758678002462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678002463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678002464 non-specific DNA binding site [nucleotide binding]; other site 758678002465 sequence-specific DNA binding site [nucleotide binding]; other site 758678002466 salt bridge; other site 758678002467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002469 active site 758678002470 phosphorylation site [posttranslational modification] 758678002471 intermolecular recognition site; other site 758678002472 dimerization interface [polypeptide binding]; other site 758678002473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002474 DNA binding site [nucleotide binding] 758678002475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678002476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002477 dimer interface [polypeptide binding]; other site 758678002478 phosphorylation site [posttranslational modification] 758678002479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002480 ATP binding site [chemical binding]; other site 758678002481 Mg2+ binding site [ion binding]; other site 758678002482 G-X-G motif; other site 758678002483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678002484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678002485 Walker A/P-loop; other site 758678002486 ATP binding site [chemical binding]; other site 758678002487 Q-loop/lid; other site 758678002488 ABC transporter signature motif; other site 758678002489 Walker B; other site 758678002490 D-loop; other site 758678002491 H-loop/switch region; other site 758678002492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678002493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678002494 FtsX-like permease family; Region: FtsX; pfam02687 758678002495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678002496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678002497 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 758678002498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678002499 FeS/SAM binding site; other site 758678002500 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 758678002501 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002502 DNA binding residues [nucleotide binding] 758678002503 dimer interface [polypeptide binding]; other site 758678002504 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 758678002505 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 758678002506 putative hexamer interface [polypeptide binding]; other site 758678002507 putative hexagonal pore; other site 758678002508 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 758678002509 putative hexamer interface [polypeptide binding]; other site 758678002510 putative hexagonal pore; other site 758678002511 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 758678002512 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758678002513 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 758678002514 active site 758678002515 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 758678002516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678002518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002519 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 758678002520 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 758678002521 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 758678002522 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 758678002523 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 758678002524 Predicted membrane protein [Function unknown]; Region: COG2510 758678002525 Predicted membrane protein [Function unknown]; Region: COG2510 758678002526 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 758678002527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 758678002528 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 758678002529 YmaF family; Region: YmaF; pfam12788 758678002530 Amino acid permease; Region: AA_permease_2; pfam13520 758678002531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678002532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678002533 Walker A/P-loop; other site 758678002534 ATP binding site [chemical binding]; other site 758678002535 Q-loop/lid; other site 758678002536 ABC transporter signature motif; other site 758678002537 Walker B; other site 758678002538 D-loop; other site 758678002539 H-loop/switch region; other site 758678002540 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 758678002541 FtsX-like permease family; Region: FtsX; pfam02687 758678002542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002544 active site 758678002545 phosphorylation site [posttranslational modification] 758678002546 intermolecular recognition site; other site 758678002547 dimerization interface [polypeptide binding]; other site 758678002548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002549 DNA binding site [nucleotide binding] 758678002550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678002551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678002552 dimerization interface [polypeptide binding]; other site 758678002553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002554 dimer interface [polypeptide binding]; other site 758678002555 phosphorylation site [posttranslational modification] 758678002556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002557 ATP binding site [chemical binding]; other site 758678002558 Mg2+ binding site [ion binding]; other site 758678002559 G-X-G motif; other site 758678002560 BioY family; Region: BioY; pfam02632 758678002561 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 758678002562 Sel1-like repeats; Region: SEL1; smart00671 758678002563 Sel1-like repeats; Region: SEL1; smart00671 758678002564 Sel1-like repeats; Region: SEL1; smart00671 758678002565 Sel1-like repeats; Region: SEL1; smart00671 758678002566 putative acetyltransferase YhhY; Provisional; Region: PRK10140 758678002567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002568 Coenzyme A binding pocket [chemical binding]; other site 758678002569 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 758678002570 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 758678002571 Catalytic site [active] 758678002572 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 758678002573 homotrimer interface [polypeptide binding]; other site 758678002574 Walker A motif; other site 758678002575 GTP binding site [chemical binding]; other site 758678002576 Walker B motif; other site 758678002577 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 758678002578 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002579 DNA binding residues [nucleotide binding] 758678002580 dimer interface [polypeptide binding]; other site 758678002581 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 758678002582 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 758678002583 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 758678002584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678002585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002586 homodimer interface [polypeptide binding]; other site 758678002587 catalytic residue [active] 758678002588 cobalt transport protein CbiM; Validated; Region: PRK08319 758678002589 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 758678002590 cobalt transport protein CbiN; Provisional; Region: PRK02898 758678002591 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 758678002592 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 758678002593 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 758678002594 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 758678002595 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 758678002596 domain interfaces; other site 758678002597 active site 758678002598 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 758678002599 dimer interface [polypeptide binding]; other site 758678002600 active site 758678002601 Schiff base residues; other site 758678002602 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 758678002603 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 758678002604 catalytic triad [active] 758678002605 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678002606 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678002607 maltose O-acetyltransferase; Provisional; Region: PRK10092 758678002608 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 758678002609 active site 758678002610 substrate binding site [chemical binding]; other site 758678002611 trimer interface [polypeptide binding]; other site 758678002612 CoA binding site [chemical binding]; other site 758678002613 Predicted ATPase [General function prediction only]; Region: COG3910 758678002614 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 758678002615 Walker A/P-loop; other site 758678002616 ATP binding site [chemical binding]; other site 758678002617 Q-loop/lid; other site 758678002618 ABC transporter signature motif; other site 758678002619 Walker B; other site 758678002620 D-loop; other site 758678002621 H-loop/switch region; other site 758678002622 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 758678002623 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002624 DNA binding residues [nucleotide binding] 758678002625 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678002626 Coenzyme A binding pocket [chemical binding]; other site 758678002627 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 758678002628 FMN binding site [chemical binding]; other site 758678002629 dimer interface [polypeptide binding]; other site 758678002630 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 758678002631 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 758678002632 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 758678002633 active site 758678002634 putative homodimer interface [polypeptide binding]; other site 758678002635 SAM binding site [chemical binding]; other site 758678002636 SdpI/YhfL protein family; Region: SdpI; pfam13630 758678002637 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 758678002638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678002639 S-adenosylmethionine binding site [chemical binding]; other site 758678002640 hypothetical protein; Provisional; Region: PRK06771 758678002641 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678002642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002643 Coenzyme A binding pocket [chemical binding]; other site 758678002644 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 758678002645 active site 758678002646 SAM binding site [chemical binding]; other site 758678002647 homodimer interface [polypeptide binding]; other site 758678002648 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 758678002649 active site 758678002650 SAM binding site [chemical binding]; other site 758678002651 homodimer interface [polypeptide binding]; other site 758678002652 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 758678002653 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 758678002654 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 758678002655 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 758678002656 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 758678002657 active site 758678002658 SAM binding site [chemical binding]; other site 758678002659 homodimer interface [polypeptide binding]; other site 758678002660 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 758678002661 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 758678002662 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 758678002663 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 758678002664 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 758678002665 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 758678002666 active site 758678002667 C-terminal domain interface [polypeptide binding]; other site 758678002668 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 758678002669 active site 758678002670 N-terminal domain interface [polypeptide binding]; other site 758678002671 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 758678002672 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 758678002673 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 758678002674 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 758678002675 homodimer interface [polypeptide binding]; other site 758678002676 Walker A motif; other site 758678002677 ATP binding site [chemical binding]; other site 758678002678 hydroxycobalamin binding site [chemical binding]; other site 758678002679 Walker B motif; other site 758678002680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758678002681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678002682 ligand binding site [chemical binding]; other site 758678002683 flexible hinge region; other site 758678002684 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758678002685 putative switch regulator; other site 758678002686 non-specific DNA interactions [nucleotide binding]; other site 758678002687 DNA binding site [nucleotide binding] 758678002688 sequence specific DNA binding site [nucleotide binding]; other site 758678002689 putative cAMP binding site [chemical binding]; other site 758678002690 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 758678002691 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 758678002692 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 758678002693 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 758678002694 FAD binding pocket [chemical binding]; other site 758678002695 FAD binding motif [chemical binding]; other site 758678002696 phosphate binding motif [ion binding]; other site 758678002697 beta-alpha-beta structure motif; other site 758678002698 NAD binding pocket [chemical binding]; other site 758678002699 Iron coordination center [ion binding]; other site 758678002700 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 758678002701 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758678002702 4Fe-4S binding domain; Region: Fer4; pfam00037 758678002703 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 758678002704 putative MPT binding site; other site 758678002705 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678002706 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678002707 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 758678002708 Walker A/P-loop; other site 758678002709 ATP binding site [chemical binding]; other site 758678002710 Q-loop/lid; other site 758678002711 ABC transporter signature motif; other site 758678002712 Walker B; other site 758678002713 D-loop; other site 758678002714 H-loop/switch region; other site 758678002715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002717 active site 758678002718 phosphorylation site [posttranslational modification] 758678002719 intermolecular recognition site; other site 758678002720 dimerization interface [polypeptide binding]; other site 758678002721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002722 DNA binding site [nucleotide binding] 758678002723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002724 dimer interface [polypeptide binding]; other site 758678002725 phosphorylation site [posttranslational modification] 758678002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002727 ATP binding site [chemical binding]; other site 758678002728 Mg2+ binding site [ion binding]; other site 758678002729 G-X-G motif; other site 758678002730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678002731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678002732 Walker A/P-loop; other site 758678002733 ATP binding site [chemical binding]; other site 758678002734 Q-loop/lid; other site 758678002735 ABC transporter signature motif; other site 758678002736 Walker B; other site 758678002737 D-loop; other site 758678002738 H-loop/switch region; other site 758678002739 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 758678002740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678002741 ABC-ATPase subunit interface; other site 758678002742 dimer interface [polypeptide binding]; other site 758678002743 putative PBP binding regions; other site 758678002744 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 758678002745 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 758678002746 putative ligand binding residues [chemical binding]; other site 758678002747 dihydroxyacetone kinase; Provisional; Region: PRK14479 758678002748 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 758678002749 DAK2 domain; Region: Dak2; pfam02734 758678002750 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 758678002751 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 758678002752 dimer interface [polypeptide binding]; other site 758678002753 active site 758678002754 metal binding site [ion binding]; metal-binding site 758678002755 Sensory domain found in PocR; Region: PocR; pfam10114 758678002756 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 758678002757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678002759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678002761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002762 Coenzyme A binding pocket [chemical binding]; other site 758678002763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002764 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678002765 Coenzyme A binding pocket [chemical binding]; other site 758678002766 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 758678002767 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 758678002768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758678002769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758678002770 active site 758678002771 catalytic tetrad [active] 758678002772 TfoX N-terminal domain; Region: TfoX_N; pfam04993 758678002773 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678002774 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678002775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002776 Coenzyme A binding pocket [chemical binding]; other site 758678002777 Predicted membrane protein [Function unknown]; Region: COG1511 758678002778 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 758678002779 Predicted membrane protein [Function unknown]; Region: COG1511 758678002780 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 758678002781 Predicted membrane protein [Function unknown]; Region: COG1511 758678002782 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 758678002783 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 758678002784 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 758678002785 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 758678002786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678002787 ATP binding site [chemical binding]; other site 758678002788 putative Mg++ binding site [ion binding]; other site 758678002789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678002790 nucleotide binding region [chemical binding]; other site 758678002791 ATP-binding site [chemical binding]; other site 758678002792 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 758678002793 HRDC domain; Region: HRDC; pfam00570 758678002794 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 758678002795 Rubrerythrin [Energy production and conversion]; Region: COG1592 758678002796 diiron binding motif [ion binding]; other site 758678002797 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 758678002798 active site 758678002799 metal binding site [ion binding]; metal-binding site 758678002800 homotetramer interface [polypeptide binding]; other site 758678002801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678002802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002803 active site 758678002804 phosphorylation site [posttranslational modification] 758678002805 intermolecular recognition site; other site 758678002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 758678002807 TPR repeat; Region: TPR_11; pfam13414 758678002808 TPR motif; other site 758678002809 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 758678002810 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 758678002811 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 758678002812 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 758678002813 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 758678002814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678002815 FeS/SAM binding site; other site 758678002816 Ycf46; Provisional; Region: ycf46; CHL00195 758678002817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678002818 Walker A motif; other site 758678002819 ATP binding site [chemical binding]; other site 758678002820 Walker B motif; other site 758678002821 arginine finger; other site 758678002822 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 758678002823 L-lactate permease; Region: Lactate_perm; cl00701 758678002824 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 758678002825 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 758678002826 Ligand binding site [chemical binding]; other site 758678002827 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758678002828 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 758678002829 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758678002830 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 758678002831 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758678002832 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758678002833 FAD binding domain; Region: FAD_binding_4; pfam01565 758678002834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678002835 MarR family; Region: MarR; pfam01047 758678002836 Putative cyclase; Region: Cyclase; pfam04199 758678002837 aspartate aminotransferase; Provisional; Region: PRK06836 758678002838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678002839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678002840 homodimer interface [polypeptide binding]; other site 758678002841 catalytic residue [active] 758678002842 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 758678002843 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 758678002844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678002845 DNA binding residues [nucleotide binding] 758678002846 drug binding residues [chemical binding]; other site 758678002847 dimer interface [polypeptide binding]; other site 758678002848 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 758678002849 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 758678002850 B3/4 domain; Region: B3_4; pfam03483 758678002851 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 758678002852 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 758678002853 Dimer interface [polypeptide binding]; other site 758678002854 anticodon binding site; other site 758678002855 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 758678002856 homodimer interface [polypeptide binding]; other site 758678002857 motif 1; other site 758678002858 motif 2; other site 758678002859 active site 758678002860 motif 3; other site 758678002861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678002862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678002863 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 758678002864 flavodoxin; Provisional; Region: PRK06242 758678002865 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 758678002866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678002867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678002868 WHG domain; Region: WHG; pfam13305 758678002869 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 758678002870 dUMP phosphatase; Provisional; Region: PRK09449 758678002871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678002872 motif II; other site 758678002873 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 758678002874 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678002875 ligand binding site [chemical binding]; other site 758678002876 flexible hinge region; other site 758678002877 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758678002878 DJ-1 family protein; Region: not_thiJ; TIGR01383 758678002879 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 758678002880 conserved cys residue [active] 758678002881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758678002882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678002883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758678002884 dimerization interface [polypeptide binding]; other site 758678002885 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678002886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678002887 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 758678002888 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 758678002889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758678002890 Coenzyme A binding pocket [chemical binding]; other site 758678002891 YoaP-like; Region: YoaP; pfam14268 758678002892 FeoA domain; Region: FeoA; pfam04023 758678002893 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 758678002894 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 758678002895 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 758678002896 G1 box; other site 758678002897 GTP/Mg2+ binding site [chemical binding]; other site 758678002898 Switch I region; other site 758678002899 G2 box; other site 758678002900 G3 box; other site 758678002901 Switch II region; other site 758678002902 G4 box; other site 758678002903 G5 box; other site 758678002904 Nucleoside recognition; Region: Gate; pfam07670 758678002905 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 758678002906 Nucleoside recognition; Region: Gate; pfam07670 758678002907 Predicted membrane protein [Function unknown]; Region: COG2323 758678002908 putative acetyltransferase; Provisional; Region: PRK03624 758678002909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678002910 Coenzyme A binding pocket [chemical binding]; other site 758678002911 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 758678002912 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 758678002913 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 758678002914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678002915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678002916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002918 active site 758678002919 phosphorylation site [posttranslational modification] 758678002920 intermolecular recognition site; other site 758678002921 dimerization interface [polypeptide binding]; other site 758678002922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002923 DNA binding site [nucleotide binding] 758678002924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002925 dimer interface [polypeptide binding]; other site 758678002926 phosphorylation site [posttranslational modification] 758678002927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002928 ATP binding site [chemical binding]; other site 758678002929 Mg2+ binding site [ion binding]; other site 758678002930 G-X-G motif; other site 758678002931 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 758678002932 Cytochrome P450; Region: p450; cl12078 758678002933 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678002934 metal-binding site [ion binding] 758678002935 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 758678002936 Family description; Region: DsbD_2; pfam13386 758678002937 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 758678002938 Predicted membrane protein [Function unknown]; Region: COG3462 758678002939 Short C-terminal domain; Region: SHOCT; pfam09851 758678002940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678002941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678002942 active site 758678002943 phosphorylation site [posttranslational modification] 758678002944 intermolecular recognition site; other site 758678002945 dimerization interface [polypeptide binding]; other site 758678002946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678002947 DNA binding site [nucleotide binding] 758678002948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678002949 HAMP domain; Region: HAMP; pfam00672 758678002950 dimerization interface [polypeptide binding]; other site 758678002951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678002952 dimer interface [polypeptide binding]; other site 758678002953 phosphorylation site [posttranslational modification] 758678002954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678002955 ATP binding site [chemical binding]; other site 758678002956 Mg2+ binding site [ion binding]; other site 758678002957 G-X-G motif; other site 758678002958 A new structural DNA glycosylase; Region: AlkD_like; cd06561 758678002959 active site 758678002960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678002962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002963 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758678002964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678002965 ABC-ATPase subunit interface; other site 758678002966 dimer interface [polypeptide binding]; other site 758678002967 putative PBP binding regions; other site 758678002968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678002969 ABC-ATPase subunit interface; other site 758678002970 dimer interface [polypeptide binding]; other site 758678002971 putative PBP binding regions; other site 758678002972 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 758678002973 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678002974 Walker A/P-loop; other site 758678002975 ATP binding site [chemical binding]; other site 758678002976 Q-loop/lid; other site 758678002977 ABC transporter signature motif; other site 758678002978 Walker B; other site 758678002979 D-loop; other site 758678002980 H-loop/switch region; other site 758678002981 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 758678002982 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 758678002983 putative ligand binding residues [chemical binding]; other site 758678002984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678002985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678002986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678002987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678002988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678002989 Walker A/P-loop; other site 758678002990 ATP binding site [chemical binding]; other site 758678002991 Q-loop/lid; other site 758678002992 ABC transporter signature motif; other site 758678002993 Walker B; other site 758678002994 D-loop; other site 758678002995 H-loop/switch region; other site 758678002996 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678002997 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678002998 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 758678002999 Walker A/P-loop; other site 758678003000 ATP binding site [chemical binding]; other site 758678003001 Q-loop/lid; other site 758678003002 ABC transporter signature motif; other site 758678003003 Walker B; other site 758678003004 D-loop; other site 758678003005 H-loop/switch region; other site 758678003006 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 758678003007 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 758678003008 ATP binding site [chemical binding]; other site 758678003009 Mg2+ binding site [ion binding]; other site 758678003010 G-X-G motif; other site 758678003011 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 758678003012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678003013 active site 758678003014 phosphorylation site [posttranslational modification] 758678003015 intermolecular recognition site; other site 758678003016 dimerization interface [polypeptide binding]; other site 758678003017 LytTr DNA-binding domain; Region: LytTR; smart00850 758678003018 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 758678003019 conserved repeat domain; Region: B_ant_repeat; TIGR01451 758678003020 Domain of unknown function DUF11; Region: DUF11; pfam01345 758678003021 Domain of unknown function DUF11; Region: DUF11; cl17728 758678003022 Domain of unknown function DUF11; Region: DUF11; pfam01345 758678003023 Domain of unknown function DUF11; Region: DUF11; pfam01345 758678003024 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 758678003025 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 758678003026 putative active site [active] 758678003027 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 758678003028 Interdomain contacts; other site 758678003029 Cytokine receptor motif; other site 758678003030 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 758678003031 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 758678003032 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 758678003033 catalytic residues [active] 758678003034 Predicted membrane protein [Function unknown]; Region: COG4129 758678003035 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 758678003036 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 758678003037 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 758678003038 CAAX protease self-immunity; Region: Abi; pfam02517 758678003039 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 758678003040 Nucleoside recognition; Region: Gate; pfam07670 758678003041 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 758678003042 ArsC family; Region: ArsC; pfam03960 758678003043 catalytic residue [active] 758678003044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678003045 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 758678003046 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 758678003047 Predicted dehydrogenase [General function prediction only]; Region: COG0579 758678003048 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758678003049 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758678003050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758678003051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758678003052 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 758678003053 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 758678003054 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 758678003055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678003056 putative substrate translocation pore; other site 758678003057 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 758678003058 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 758678003059 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 758678003060 active site 758678003061 HIGH motif; other site 758678003062 KMSK motif region; other site 758678003063 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 758678003064 tRNA binding surface [nucleotide binding]; other site 758678003065 anticodon binding site; other site 758678003066 transaminase; Validated; Region: PRK07324 758678003067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678003068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678003069 homodimer interface [polypeptide binding]; other site 758678003070 catalytic residue [active] 758678003071 FOG: CBS domain [General function prediction only]; Region: COG0517 758678003072 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 758678003073 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 758678003074 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 758678003075 G1 box; other site 758678003076 GTP/Mg2+ binding site [chemical binding]; other site 758678003077 Switch I region; other site 758678003078 G2 box; other site 758678003079 G3 box; other site 758678003080 Switch II region; other site 758678003081 G4 box; other site 758678003082 G5 box; other site 758678003083 Nucleoside recognition; Region: Gate; pfam07670 758678003084 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 758678003085 Nucleoside recognition; Region: Gate; pfam07670 758678003086 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 758678003087 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 758678003088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678003089 motif II; other site 758678003090 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 758678003091 active site 758678003092 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 758678003093 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 758678003094 aromatic chitin/cellulose binding site residues [chemical binding]; other site 758678003095 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 758678003096 aromatic chitin/cellulose binding site residues [chemical binding]; other site 758678003097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678003098 Coenzyme A binding pocket [chemical binding]; other site 758678003099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003100 dimer interface [polypeptide binding]; other site 758678003101 conserved gate region; other site 758678003102 ABC-ATPase subunit interface; other site 758678003103 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758678003104 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758678003105 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758678003106 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758678003107 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758678003108 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 758678003109 metal binding site [ion binding]; metal-binding site 758678003110 putative dimer interface [polypeptide binding]; other site 758678003111 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758678003112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678003113 DNA-binding site [nucleotide binding]; DNA binding site 758678003114 FCD domain; Region: FCD; pfam07729 758678003115 Uncharacterized conserved protein [Function unknown]; Region: COG1284 758678003116 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 758678003117 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 758678003118 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 758678003119 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 758678003120 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 758678003121 active site 758678003122 HIGH motif; other site 758678003123 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 758678003124 active site 758678003125 KMSKS motif; other site 758678003126 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 758678003127 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 758678003128 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 758678003129 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 758678003130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 758678003131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678003132 Beta-Casp domain; Region: Beta-Casp; smart01027 758678003133 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 758678003134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678003135 Zn2+ binding site [ion binding]; other site 758678003136 Mg2+ binding site [ion binding]; other site 758678003137 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 758678003138 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 758678003139 NAD(P) binding site [chemical binding]; other site 758678003140 catalytic residues [active] 758678003141 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678003142 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758678003143 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678003144 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758678003145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678003146 MarR family; Region: MarR_2; pfam12802 758678003147 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678003148 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678003149 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 758678003150 hypothetical protein; Provisional; Region: PRK11622 758678003151 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758678003152 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758678003153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003154 dimer interface [polypeptide binding]; other site 758678003155 conserved gate region; other site 758678003156 putative PBP binding loops; other site 758678003157 ABC-ATPase subunit interface; other site 758678003158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758678003159 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 758678003160 Walker A/P-loop; other site 758678003161 ATP binding site [chemical binding]; other site 758678003162 Q-loop/lid; other site 758678003163 ABC transporter signature motif; other site 758678003164 Walker B; other site 758678003165 D-loop; other site 758678003166 H-loop/switch region; other site 758678003167 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 758678003168 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678003169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678003170 Coenzyme A binding pocket [chemical binding]; other site 758678003171 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758678003172 catalytic residues [active] 758678003173 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 758678003174 maltose O-acetyltransferase; Provisional; Region: PRK10092 758678003175 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 758678003176 active site 758678003177 substrate binding site [chemical binding]; other site 758678003178 trimer interface [polypeptide binding]; other site 758678003179 CoA binding site [chemical binding]; other site 758678003180 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 758678003181 Biotin operon repressor [Transcription]; Region: BirA; COG1654 758678003182 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 758678003183 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 758678003184 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678003185 metal-binding site [ion binding] 758678003186 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 758678003187 FOG: CBS domain [General function prediction only]; Region: COG0517 758678003188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678003189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678003190 dimer interface [polypeptide binding]; other site 758678003191 phosphorylation site [posttranslational modification] 758678003192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003193 ATP binding site [chemical binding]; other site 758678003194 Mg2+ binding site [ion binding]; other site 758678003195 G-X-G motif; other site 758678003196 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 758678003197 nucleophile elbow; other site 758678003198 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 758678003199 MgtE intracellular N domain; Region: MgtE_N; smart00924 758678003200 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 758678003201 Divalent cation transporter; Region: MgtE; pfam01769 758678003202 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 758678003203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678003204 catalytic residue [active] 758678003205 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 758678003206 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 758678003207 putative ligand binding site [chemical binding]; other site 758678003208 NAD binding site [chemical binding]; other site 758678003209 dimerization interface [polypeptide binding]; other site 758678003210 catalytic site [active] 758678003211 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 758678003212 Uncharacterized conserved protein [Function unknown]; Region: COG4198 758678003213 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 758678003214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678003215 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678003216 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678003217 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 758678003218 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678003219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 758678003220 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678003221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 758678003222 BCCT family transporter; Region: BCCT; pfam02028 758678003223 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758678003224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678003225 DNA-binding site [nucleotide binding]; DNA binding site 758678003226 TrkA-C domain; Region: TrkA_C; pfam02080 758678003227 Flavin Reductases; Region: FlaRed; cl00801 758678003228 Isochorismatase family; Region: Isochorismatase; pfam00857 758678003229 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 758678003230 catalytic triad [active] 758678003231 conserved cis-peptide bond; other site 758678003232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 758678003233 active site residue [active] 758678003234 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 758678003235 TPR repeat; Region: TPR_11; pfam13414 758678003236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678003237 binding surface 758678003238 TPR motif; other site 758678003239 TPR repeat; Region: TPR_11; pfam13414 758678003240 TPR repeat; Region: TPR_11; pfam13414 758678003241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678003242 binding surface 758678003243 TPR motif; other site 758678003244 TPR repeat; Region: TPR_11; pfam13414 758678003245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678003246 active site 758678003247 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758678003248 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758678003249 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 758678003250 putative metal binding site [ion binding]; other site 758678003251 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 758678003252 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 758678003253 active site 758678003254 metal-binding site [ion binding] 758678003255 nucleotide-binding site [chemical binding]; other site 758678003256 nucleotide-binding site [chemical binding]; other site 758678003257 potential frameshift: common BLAST hit: gi|153941160|ref|YP_001390501.1| ABC transporter substrate-binding protein 758678003258 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758678003259 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 758678003260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003261 dimer interface [polypeptide binding]; other site 758678003262 conserved gate region; other site 758678003263 putative PBP binding loops; other site 758678003264 ABC-ATPase subunit interface; other site 758678003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003266 dimer interface [polypeptide binding]; other site 758678003267 conserved gate region; other site 758678003268 putative PBP binding loops; other site 758678003269 ABC-ATPase subunit interface; other site 758678003270 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758678003271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003272 Walker A/P-loop; other site 758678003273 ATP binding site [chemical binding]; other site 758678003274 Q-loop/lid; other site 758678003275 ABC transporter signature motif; other site 758678003276 Walker B; other site 758678003277 D-loop; other site 758678003278 H-loop/switch region; other site 758678003279 TOBE domain; Region: TOBE_2; pfam08402 758678003280 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 758678003281 Double zinc ribbon; Region: DZR; pfam12773 758678003282 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 758678003283 Double zinc ribbon; Region: DZR; pfam12773 758678003284 YARHG domain; Region: YARHG; pfam13308 758678003285 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 758678003286 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 758678003287 RNA binding site [nucleotide binding]; other site 758678003288 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 758678003289 RNA binding site [nucleotide binding]; other site 758678003290 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 758678003291 RNA binding site [nucleotide binding]; other site 758678003292 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 758678003293 RNA binding site [nucleotide binding]; other site 758678003294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758678003295 active site 758678003296 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 758678003297 hexamer interface [polypeptide binding]; other site 758678003298 RNA binding site [nucleotide binding]; other site 758678003299 Histidine-zinc binding site [chemical binding]; other site 758678003300 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 758678003301 zinc binding site [ion binding]; other site 758678003302 putative ligand binding site [chemical binding]; other site 758678003303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758678003304 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 758678003305 TM-ABC transporter signature motif; other site 758678003306 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 758678003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003308 Walker A/P-loop; other site 758678003309 ATP binding site [chemical binding]; other site 758678003310 Q-loop/lid; other site 758678003311 ABC transporter signature motif; other site 758678003312 Walker B; other site 758678003313 D-loop; other site 758678003314 H-loop/switch region; other site 758678003315 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758678003316 EamA-like transporter family; Region: EamA; pfam00892 758678003317 EamA-like transporter family; Region: EamA; pfam00892 758678003318 putative kinase; Provisional; Region: PRK09954 758678003319 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 758678003320 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 758678003321 substrate binding site [chemical binding]; other site 758678003322 ATP binding site [chemical binding]; other site 758678003323 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 758678003324 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 758678003325 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758678003326 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758678003327 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 758678003328 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 758678003329 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 758678003330 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 758678003331 homodimer interface [polypeptide binding]; other site 758678003332 NADP binding site [chemical binding]; other site 758678003333 substrate binding site [chemical binding]; other site 758678003334 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 758678003335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678003336 active site 758678003337 motif I; other site 758678003338 motif II; other site 758678003339 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758678003340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678003341 Coenzyme A binding pocket [chemical binding]; other site 758678003342 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 758678003343 ZIP Zinc transporter; Region: Zip; pfam02535 758678003344 Predicted transcriptional regulator [Transcription]; Region: COG1959 758678003345 Transcriptional regulator; Region: Rrf2; cl17282 758678003346 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 758678003347 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 758678003348 dimer interface [polypeptide binding]; other site 758678003349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678003350 catalytic residue [active] 758678003351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758678003352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003353 dimer interface [polypeptide binding]; other site 758678003354 conserved gate region; other site 758678003355 putative PBP binding loops; other site 758678003356 ABC-ATPase subunit interface; other site 758678003357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758678003358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758678003359 substrate binding pocket [chemical binding]; other site 758678003360 membrane-bound complex binding site; other site 758678003361 hinge residues; other site 758678003362 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 758678003363 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 758678003364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678003365 catalytic residue [active] 758678003366 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 758678003367 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 758678003368 Ligand Binding Site [chemical binding]; other site 758678003369 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 758678003370 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 758678003371 Ligand Binding Site [chemical binding]; other site 758678003372 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 758678003373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678003374 active site 758678003375 phosphorylation site [posttranslational modification] 758678003376 intermolecular recognition site; other site 758678003377 LytTr DNA-binding domain; Region: LytTR; pfam04397 758678003378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003379 ATP binding site [chemical binding]; other site 758678003380 Mg2+ binding site [ion binding]; other site 758678003381 G-X-G motif; other site 758678003382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678003383 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 758678003384 Walker A/P-loop; other site 758678003385 ATP binding site [chemical binding]; other site 758678003386 Q-loop/lid; other site 758678003387 ABC transporter signature motif; other site 758678003388 Walker B; other site 758678003389 D-loop; other site 758678003390 H-loop/switch region; other site 758678003391 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 758678003392 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 758678003393 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 758678003394 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 758678003395 active site 758678003396 catalytic site [active] 758678003397 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 758678003398 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 758678003399 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758678003400 dimer interface [polypeptide binding]; other site 758678003401 PYR/PP interface [polypeptide binding]; other site 758678003402 TPP binding site [chemical binding]; other site 758678003403 substrate binding site [chemical binding]; other site 758678003404 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 758678003405 Domain of unknown function; Region: EKR; pfam10371 758678003406 4Fe-4S binding domain; Region: Fer4_6; pfam12837 758678003407 4Fe-4S binding domain; Region: Fer4; pfam00037 758678003408 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 758678003409 TPP-binding site [chemical binding]; other site 758678003410 dimer interface [polypeptide binding]; other site 758678003411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678003412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678003413 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 758678003414 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758678003415 Uncharacterized conserved protein [Function unknown]; Region: COG0397 758678003416 hypothetical protein; Validated; Region: PRK00029 758678003417 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 758678003418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678003419 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758678003420 Helix-turn-helix domain; Region: HTH_18; pfam12833 758678003421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678003422 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 758678003423 MFS/sugar transport protein; Region: MFS_2; pfam13347 758678003424 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 758678003425 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 758678003426 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678003427 nucleotide binding site [chemical binding]; other site 758678003428 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 758678003429 beta-galactosidase; Region: BGL; TIGR03356 758678003430 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 758678003431 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 758678003432 starch-binding site 2 [chemical binding]; other site 758678003433 starch-binding site 1 [chemical binding]; other site 758678003434 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 758678003435 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 758678003436 active site 758678003437 HIGH motif; other site 758678003438 dimer interface [polypeptide binding]; other site 758678003439 KMSKS motif; other site 758678003440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678003441 RNA binding surface [nucleotide binding]; other site 758678003442 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678003443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678003444 DNA-binding site [nucleotide binding]; DNA binding site 758678003445 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678003446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003447 Walker A/P-loop; other site 758678003448 ATP binding site [chemical binding]; other site 758678003449 Q-loop/lid; other site 758678003450 ABC transporter signature motif; other site 758678003451 Walker B; other site 758678003452 D-loop; other site 758678003453 H-loop/switch region; other site 758678003454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678003455 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 758678003456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678003457 Bacterial SH3 domain; Region: SH3_3; pfam08239 758678003458 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 758678003459 active site 758678003460 PAS domain S-box; Region: sensory_box; TIGR00229 758678003461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678003462 putative active site [active] 758678003463 heme pocket [chemical binding]; other site 758678003464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678003465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678003466 metal binding site [ion binding]; metal-binding site 758678003467 active site 758678003468 I-site; other site 758678003469 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 758678003470 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 758678003471 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 758678003472 putative L-serine binding site [chemical binding]; other site 758678003473 Uncharacterized conserved protein [Function unknown]; Region: COG5663 758678003474 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758678003475 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 758678003476 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 758678003477 active site 758678003478 dimer interface [polypeptide binding]; other site 758678003479 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 758678003480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678003481 FtsX-like permease family; Region: FtsX; pfam02687 758678003482 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 758678003483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678003484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678003485 Walker A/P-loop; other site 758678003486 ATP binding site [chemical binding]; other site 758678003487 Q-loop/lid; other site 758678003488 ABC transporter signature motif; other site 758678003489 Walker B; other site 758678003490 D-loop; other site 758678003491 H-loop/switch region; other site 758678003492 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 758678003493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003494 dimer interface [polypeptide binding]; other site 758678003495 conserved gate region; other site 758678003496 putative PBP binding loops; other site 758678003497 ABC-ATPase subunit interface; other site 758678003498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758678003499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003500 dimer interface [polypeptide binding]; other site 758678003501 conserved gate region; other site 758678003502 putative PBP binding loops; other site 758678003503 ABC-ATPase subunit interface; other site 758678003504 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758678003505 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 758678003506 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 758678003507 CotJB protein; Region: CotJB; pfam12652 758678003508 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 758678003509 dimanganese center [ion binding]; other site 758678003510 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 758678003511 Tubby C 2; Region: Tub_2; cl02043 758678003512 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 758678003513 trimer interface [polypeptide binding]; other site 758678003514 active site 758678003515 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 758678003516 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 758678003517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678003518 non-specific DNA binding site [nucleotide binding]; other site 758678003519 salt bridge; other site 758678003520 sequence-specific DNA binding site [nucleotide binding]; other site 758678003521 Cupin domain; Region: Cupin_2; pfam07883 758678003522 potential frameshift: common BLAST hit: gi|170761538|ref|YP_001786629.1| transcriptional regulator 758678003523 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 758678003524 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 758678003525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678003526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678003527 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 758678003528 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678003529 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 758678003530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678003531 non-specific DNA binding site [nucleotide binding]; other site 758678003532 salt bridge; other site 758678003533 sequence-specific DNA binding site [nucleotide binding]; other site 758678003534 Helix-turn-helix domain; Region: HTH_17; pfam12728 758678003535 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 758678003536 catalytic residues [active] 758678003537 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 758678003538 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 758678003539 tetrameric interface [polypeptide binding]; other site 758678003540 activator binding site; other site 758678003541 NADP binding site [chemical binding]; other site 758678003542 substrate binding site [chemical binding]; other site 758678003543 catalytic residues [active] 758678003544 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 758678003545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758678003546 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 758678003547 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678003548 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 758678003549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758678003550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678003551 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758678003552 catalytic residues [active] 758678003553 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 758678003554 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 758678003555 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 758678003556 dimer interface [polypeptide binding]; other site 758678003557 active site 758678003558 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 758678003559 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 758678003560 active site 758678003561 DNA binding site [nucleotide binding] 758678003562 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 758678003563 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 758678003564 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 758678003565 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 758678003566 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 758678003567 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758678003568 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 758678003569 intersubunit interface [polypeptide binding]; other site 758678003570 active site 758678003571 Zn2+ binding site [ion binding]; other site 758678003572 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758678003573 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 758678003574 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758678003575 Predicted membrane protein [Function unknown]; Region: COG2323 758678003576 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 758678003577 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 758678003578 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 758678003579 A short protein domain of unknown function; Region: IDEAL; smart00914 758678003580 PQ loop repeat; Region: PQ-loop; cl17546 758678003581 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 758678003582 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758678003583 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758678003584 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 758678003585 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758678003586 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758678003587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758678003588 catalytic loop [active] 758678003589 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 758678003590 iron binding site [ion binding]; other site 758678003591 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758678003592 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 758678003593 nucleoside/Zn binding site; other site 758678003594 dimer interface [polypeptide binding]; other site 758678003595 catalytic motif [active] 758678003596 DNA topoisomerase III; Provisional; Region: PRK07726 758678003597 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 758678003598 active site 758678003599 putative interdomain interaction site [polypeptide binding]; other site 758678003600 putative metal-binding site [ion binding]; other site 758678003601 putative nucleotide binding site [chemical binding]; other site 758678003602 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 758678003603 domain I; other site 758678003604 DNA binding groove [nucleotide binding] 758678003605 phosphate binding site [ion binding]; other site 758678003606 domain II; other site 758678003607 domain III; other site 758678003608 nucleotide binding site [chemical binding]; other site 758678003609 catalytic site [active] 758678003610 domain IV; other site 758678003611 Predicted membrane protein [Function unknown]; Region: COG1971 758678003612 Domain of unknown function DUF; Region: DUF204; pfam02659 758678003613 Domain of unknown function DUF; Region: DUF204; pfam02659 758678003614 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 758678003615 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 758678003616 active site 758678003617 intersubunit interactions; other site 758678003618 catalytic residue [active] 758678003619 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 758678003620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678003621 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 758678003622 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758678003623 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678003624 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678003625 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678003626 metal binding site [ion binding]; metal-binding site 758678003627 active site 758678003628 I-site; other site 758678003629 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 758678003630 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 758678003631 NodB motif; other site 758678003632 putative active site [active] 758678003633 putative catalytic site [active] 758678003634 putative Zn binding site [ion binding]; other site 758678003635 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758678003636 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 758678003637 DXD motif; other site 758678003638 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 758678003639 Probable zinc-binding domain; Region: zf-trcl; pfam13451 758678003640 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 758678003641 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 758678003642 putative homodimer interface [polypeptide binding]; other site 758678003643 putative homotetramer interface [polypeptide binding]; other site 758678003644 putative allosteric switch controlling residues; other site 758678003645 putative metal binding site [ion binding]; other site 758678003646 putative homodimer-homodimer interface [polypeptide binding]; other site 758678003647 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 758678003648 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678003649 metal-binding site [ion binding] 758678003650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 758678003651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678003652 metal-binding site [ion binding] 758678003653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678003654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678003655 motif II; other site 758678003656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758678003657 metal-binding site [ion binding] 758678003658 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678003659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678003660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003661 Walker A/P-loop; other site 758678003662 ATP binding site [chemical binding]; other site 758678003663 Q-loop/lid; other site 758678003664 ABC transporter signature motif; other site 758678003665 Walker B; other site 758678003666 D-loop; other site 758678003667 H-loop/switch region; other site 758678003668 CAAX protease self-immunity; Region: Abi; pfam02517 758678003669 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 758678003670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678003671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758678003672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003673 ATP binding site [chemical binding]; other site 758678003674 Mg2+ binding site [ion binding]; other site 758678003675 G-X-G motif; other site 758678003676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678003677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678003678 Walker A/P-loop; other site 758678003679 ATP binding site [chemical binding]; other site 758678003680 Q-loop/lid; other site 758678003681 ABC transporter signature motif; other site 758678003682 Walker B; other site 758678003683 D-loop; other site 758678003684 H-loop/switch region; other site 758678003685 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678003686 FtsX-like permease family; Region: FtsX; pfam02687 758678003687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678003688 FtsX-like permease family; Region: FtsX; pfam02687 758678003689 EDD domain protein, DegV family; Region: DegV; TIGR00762 758678003690 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 758678003691 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 758678003692 nucleotide binding site/active site [active] 758678003693 HIT family signature motif; other site 758678003694 catalytic residue [active] 758678003695 Membrane protein of unknown function; Region: DUF360; pfam04020 758678003696 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 758678003697 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 758678003698 YibE/F-like protein; Region: YibE_F; pfam07907 758678003699 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 758678003700 TrkA-N domain; Region: TrkA_N; pfam02254 758678003701 TrkA-C domain; Region: TrkA_C; pfam02080 758678003702 TrkA-N domain; Region: TrkA_N; pfam02254 758678003703 TrkA-C domain; Region: TrkA_C; pfam02080 758678003704 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 758678003705 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 758678003706 Predicted membrane protein [General function prediction only]; Region: COG4194 758678003707 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 758678003708 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678003709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678003710 DNA-binding site [nucleotide binding]; DNA binding site 758678003711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678003712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678003713 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 758678003714 Rubrerythrin [Energy production and conversion]; Region: COG1592 758678003715 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 758678003716 binuclear metal center [ion binding]; other site 758678003717 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 758678003718 iron binding site [ion binding]; other site 758678003719 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678003720 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678003721 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678003722 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 758678003723 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 758678003724 catalytic residue [active] 758678003725 putative FPP diphosphate binding site; other site 758678003726 putative FPP binding hydrophobic cleft; other site 758678003727 dimer interface [polypeptide binding]; other site 758678003728 putative IPP diphosphate binding site; other site 758678003729 Rrf2 family protein; Region: rrf2_super; TIGR00738 758678003730 Transcriptional regulator; Region: Rrf2; pfam02082 758678003731 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 758678003732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678003733 ACS interaction site; other site 758678003734 CODH interaction site; other site 758678003735 metal cluster binding site [ion binding]; other site 758678003736 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 758678003737 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678003738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758678003739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678003740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678003741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678003742 active site 758678003743 phosphorylation site [posttranslational modification] 758678003744 intermolecular recognition site; other site 758678003745 dimerization interface [polypeptide binding]; other site 758678003746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678003747 DNA binding site [nucleotide binding] 758678003748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678003749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003750 ATP binding site [chemical binding]; other site 758678003751 Mg2+ binding site [ion binding]; other site 758678003752 G-X-G motif; other site 758678003753 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678003754 FtsX-like permease family; Region: FtsX; pfam02687 758678003755 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678003756 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678003757 Walker A/P-loop; other site 758678003758 ATP binding site [chemical binding]; other site 758678003759 Q-loop/lid; other site 758678003760 ABC transporter signature motif; other site 758678003761 Walker B; other site 758678003762 D-loop; other site 758678003763 H-loop/switch region; other site 758678003764 EamA-like transporter family; Region: EamA; pfam00892 758678003765 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758678003766 EamA-like transporter family; Region: EamA; pfam00892 758678003767 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758678003768 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678003769 ligand binding site [chemical binding]; other site 758678003770 flexible hinge region; other site 758678003771 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758678003772 putative switch regulator; other site 758678003773 non-specific DNA interactions [nucleotide binding]; other site 758678003774 DNA binding site [nucleotide binding] 758678003775 sequence specific DNA binding site [nucleotide binding]; other site 758678003776 putative cAMP binding site [chemical binding]; other site 758678003777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678003778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758678003779 putative substrate translocation pore; other site 758678003780 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 758678003781 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 758678003782 putative binding site residues; other site 758678003783 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 758678003784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678003785 ABC-ATPase subunit interface; other site 758678003786 dimer interface [polypeptide binding]; other site 758678003787 putative PBP binding regions; other site 758678003788 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678003789 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678003790 Walker A/P-loop; other site 758678003791 ATP binding site [chemical binding]; other site 758678003792 Q-loop/lid; other site 758678003793 ABC transporter signature motif; other site 758678003794 Walker B; other site 758678003795 D-loop; other site 758678003796 H-loop/switch region; other site 758678003797 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678003798 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758678003799 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678003800 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678003801 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678003802 putative active site [active] 758678003803 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 758678003804 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 758678003805 putative active site [active] 758678003806 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 758678003807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678003808 active site turn [active] 758678003809 phosphorylation site [posttranslational modification] 758678003810 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678003811 Uncharacterized conserved protein [Function unknown]; Region: COG3589 758678003812 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 758678003813 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 758678003814 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 758678003815 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 758678003816 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678003817 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 758678003818 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758678003819 HAMP domain; Region: HAMP; pfam00672 758678003820 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678003821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678003822 dimer interface [polypeptide binding]; other site 758678003823 putative CheW interface [polypeptide binding]; other site 758678003824 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758678003825 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 758678003826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758678003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003828 dimer interface [polypeptide binding]; other site 758678003829 conserved gate region; other site 758678003830 putative PBP binding loops; other site 758678003831 ABC-ATPase subunit interface; other site 758678003832 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 758678003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003834 dimer interface [polypeptide binding]; other site 758678003835 conserved gate region; other site 758678003836 putative PBP binding loops; other site 758678003837 ABC-ATPase subunit interface; other site 758678003838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758678003839 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 758678003840 Walker A/P-loop; other site 758678003841 ATP binding site [chemical binding]; other site 758678003842 Q-loop/lid; other site 758678003843 ABC transporter signature motif; other site 758678003844 Walker B; other site 758678003845 D-loop; other site 758678003846 H-loop/switch region; other site 758678003847 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 758678003848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758678003849 Walker A/P-loop; other site 758678003850 ATP binding site [chemical binding]; other site 758678003851 Q-loop/lid; other site 758678003852 ABC transporter signature motif; other site 758678003853 Walker B; other site 758678003854 D-loop; other site 758678003855 H-loop/switch region; other site 758678003856 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 758678003857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678003858 ABC-ATPase subunit interface; other site 758678003859 dimer interface [polypeptide binding]; other site 758678003860 putative PBP binding regions; other site 758678003861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 758678003862 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 758678003863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678003864 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 758678003865 intersubunit interface [polypeptide binding]; other site 758678003866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678003867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678003868 metal binding site [ion binding]; metal-binding site 758678003869 active site 758678003870 I-site; other site 758678003871 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758678003872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 758678003873 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758678003874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003875 dimer interface [polypeptide binding]; other site 758678003876 conserved gate region; other site 758678003877 putative PBP binding loops; other site 758678003878 ABC-ATPase subunit interface; other site 758678003879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678003880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003881 Walker A/P-loop; other site 758678003882 ATP binding site [chemical binding]; other site 758678003883 Q-loop/lid; other site 758678003884 ABC transporter signature motif; other site 758678003885 Walker B; other site 758678003886 D-loop; other site 758678003887 H-loop/switch region; other site 758678003888 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758678003889 metal binding site 2 [ion binding]; metal-binding site 758678003890 putative DNA binding helix; other site 758678003891 metal binding site 1 [ion binding]; metal-binding site 758678003892 dimer interface [polypeptide binding]; other site 758678003893 structural Zn2+ binding site [ion binding]; other site 758678003894 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 758678003895 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678003896 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678003897 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 758678003898 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678003899 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 758678003900 putative active site [active] 758678003901 Zn binding site [ion binding]; other site 758678003902 ribonuclease Z; Region: RNase_Z; TIGR02651 758678003903 L-type amino acid transporter; Region: 2A0308; TIGR00911 758678003904 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 758678003905 pentamer interface [polypeptide binding]; other site 758678003906 dodecaamer interface [polypeptide binding]; other site 758678003907 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 758678003908 Histidine kinase; Region: HisKA_3; pfam07730 758678003909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003910 ATP binding site [chemical binding]; other site 758678003911 Mg2+ binding site [ion binding]; other site 758678003912 G-X-G motif; other site 758678003913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758678003914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678003915 active site 758678003916 phosphorylation site [posttranslational modification] 758678003917 intermolecular recognition site; other site 758678003918 dimerization interface [polypeptide binding]; other site 758678003919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758678003920 DNA binding residues [nucleotide binding] 758678003921 dimerization interface [polypeptide binding]; other site 758678003922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678003923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678003924 Walker A/P-loop; other site 758678003925 ATP binding site [chemical binding]; other site 758678003926 Q-loop/lid; other site 758678003927 ABC transporter signature motif; other site 758678003928 Walker B; other site 758678003929 D-loop; other site 758678003930 H-loop/switch region; other site 758678003931 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758678003932 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 758678003933 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 758678003934 FMN binding site [chemical binding]; other site 758678003935 dimer interface [polypeptide binding]; other site 758678003936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758678003937 DNA-binding site [nucleotide binding]; DNA binding site 758678003938 RNA-binding motif; other site 758678003939 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 758678003940 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 758678003941 metal binding site [ion binding]; metal-binding site 758678003942 dimer interface [polypeptide binding]; other site 758678003943 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 758678003944 dimer interface [polypeptide binding]; other site 758678003945 pyridoxal binding site [chemical binding]; other site 758678003946 ATP binding site [chemical binding]; other site 758678003947 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 758678003948 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678003949 FtsX-like permease family; Region: FtsX; pfam02687 758678003950 FtsX-like permease family; Region: FtsX; pfam02687 758678003951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678003952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678003953 active site 758678003954 phosphorylation site [posttranslational modification] 758678003955 intermolecular recognition site; other site 758678003956 dimerization interface [polypeptide binding]; other site 758678003957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678003958 DNA binding site [nucleotide binding] 758678003959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678003960 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 758678003961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678003962 ATP binding site [chemical binding]; other site 758678003963 Mg2+ binding site [ion binding]; other site 758678003964 G-X-G motif; other site 758678003965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678003966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678003967 Walker A/P-loop; other site 758678003968 ATP binding site [chemical binding]; other site 758678003969 Q-loop/lid; other site 758678003970 ABC transporter signature motif; other site 758678003971 Walker B; other site 758678003972 D-loop; other site 758678003973 H-loop/switch region; other site 758678003974 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 758678003975 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 758678003976 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 758678003977 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 758678003978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678003980 homodimer interface [polypeptide binding]; other site 758678003981 catalytic residue [active] 758678003982 Cobalt transport protein component CbiN; Region: CbiN; cl00842 758678003983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758678003984 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758678003985 substrate binding pocket [chemical binding]; other site 758678003986 membrane-bound complex binding site; other site 758678003987 hinge residues; other site 758678003988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678003989 dimer interface [polypeptide binding]; other site 758678003990 conserved gate region; other site 758678003991 putative PBP binding loops; other site 758678003992 ABC-ATPase subunit interface; other site 758678003993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758678003994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758678003995 Walker A/P-loop; other site 758678003996 ATP binding site [chemical binding]; other site 758678003997 Q-loop/lid; other site 758678003998 ABC transporter signature motif; other site 758678003999 Walker B; other site 758678004000 D-loop; other site 758678004001 H-loop/switch region; other site 758678004002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678004003 non-specific DNA binding site [nucleotide binding]; other site 758678004004 salt bridge; other site 758678004005 sequence-specific DNA binding site [nucleotide binding]; other site 758678004006 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 758678004007 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 758678004008 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 758678004009 putative active site [active] 758678004010 putative CoA binding site [chemical binding]; other site 758678004011 nudix motif; other site 758678004012 metal binding site [ion binding]; metal-binding site 758678004013 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 758678004014 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 758678004015 dimer interface [polypeptide binding]; other site 758678004016 active site 758678004017 metal binding site [ion binding]; metal-binding site 758678004018 Predicted membrane protein [Function unknown]; Region: COG1288 758678004019 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 758678004020 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 758678004021 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 758678004022 active site 758678004023 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758678004024 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758678004025 substrate binding pocket [chemical binding]; other site 758678004026 membrane-bound complex binding site; other site 758678004027 hinge residues; other site 758678004028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758678004029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004030 dimer interface [polypeptide binding]; other site 758678004031 conserved gate region; other site 758678004032 putative PBP binding loops; other site 758678004033 ABC-ATPase subunit interface; other site 758678004034 Protein of unknown function (DUF523); Region: DUF523; cl00733 758678004035 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 758678004036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678004037 ATP binding site [chemical binding]; other site 758678004038 Family description; Region: UvrD_C_2; pfam13538 758678004039 cell division protein FtsA; Region: ftsA; TIGR01174 758678004040 Cell division protein FtsA; Region: FtsA; smart00842 758678004041 Cell division protein FtsA; Region: FtsA; pfam14450 758678004042 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758678004043 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 758678004044 metal binding site [ion binding]; metal-binding site 758678004045 dimer interface [polypeptide binding]; other site 758678004046 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678004047 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678004048 active site 758678004049 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 758678004050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678004051 RNA binding surface [nucleotide binding]; other site 758678004052 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 758678004053 active site 758678004054 stage V sporulation protein B; Region: spore_V_B; TIGR02900 758678004055 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 758678004056 stage V sporulation protein B; Region: spore_V_B; TIGR02900 758678004057 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 758678004058 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 758678004059 diiron binding motif [ion binding]; other site 758678004060 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 758678004061 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 758678004062 putative active site [active] 758678004063 metal binding site [ion binding]; metal-binding site 758678004064 AAA domain; Region: AAA_32; pfam13654 758678004065 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 758678004066 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 758678004067 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 758678004068 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 758678004069 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 758678004070 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 758678004071 active site 758678004072 Zn binding site [ion binding]; other site 758678004073 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 758678004074 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 758678004075 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 758678004076 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 758678004077 active site 758678004078 Zn binding site [ion binding]; other site 758678004079 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 758678004080 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 758678004081 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 758678004082 active site 758678004083 Zn binding site [ion binding]; other site 758678004084 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 758678004085 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 758678004086 active site 758678004087 Zn binding site [ion binding]; other site 758678004088 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 758678004089 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 758678004090 dimerization interface [polypeptide binding]; other site 758678004091 active site 758678004092 L-aspartate oxidase; Provisional; Region: PRK06175 758678004093 FAD binding domain; Region: FAD_binding_2; pfam00890 758678004094 Quinolinate synthetase A protein; Region: NadA; pfam02445 758678004095 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 758678004096 metal binding site [ion binding]; metal-binding site 758678004097 Haemolysin-III related; Region: HlyIII; cl03831 758678004098 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 758678004099 GTP-binding protein YchF; Reviewed; Region: PRK09601 758678004100 YchF GTPase; Region: YchF; cd01900 758678004101 G1 box; other site 758678004102 GTP/Mg2+ binding site [chemical binding]; other site 758678004103 Switch I region; other site 758678004104 G2 box; other site 758678004105 Switch II region; other site 758678004106 G3 box; other site 758678004107 G4 box; other site 758678004108 G5 box; other site 758678004109 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 758678004110 cell division protein MraZ; Reviewed; Region: PRK00326 758678004111 MraZ protein; Region: MraZ; pfam02381 758678004112 MraZ protein; Region: MraZ; pfam02381 758678004113 MraW methylase family; Region: Methyltransf_5; pfam01795 758678004114 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 758678004115 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 758678004116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758678004117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758678004118 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 758678004119 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 758678004120 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 758678004121 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758678004122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678004123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758678004124 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 758678004125 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758678004126 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678004127 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758678004128 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 758678004129 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 758678004130 Mg++ binding site [ion binding]; other site 758678004131 putative catalytic motif [active] 758678004132 putative substrate binding site [chemical binding]; other site 758678004133 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 758678004134 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 758678004135 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 758678004136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 758678004137 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 758678004138 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 758678004139 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 758678004140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678004141 catalytic residue [active] 758678004142 Protein of unknown function (DUF552); Region: DUF552; cl00775 758678004143 YGGT family; Region: YGGT; pfam02325 758678004144 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 758678004145 DivIVA protein; Region: DivIVA; pfam05103 758678004146 DivIVA domain; Region: DivI1A_domain; TIGR03544 758678004147 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 758678004148 active site 758678004149 dimer interface [polypeptide binding]; other site 758678004150 metal binding site [ion binding]; metal-binding site 758678004151 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 758678004152 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 758678004153 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 758678004154 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 758678004155 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 758678004156 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 758678004157 hinge; other site 758678004158 active site 758678004159 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 758678004160 lipoprotein signal peptidase; Provisional; Region: PRK14791 758678004161 lipoprotein signal peptidase; Provisional; Region: PRK14787 758678004162 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 758678004163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678004164 RNA binding surface [nucleotide binding]; other site 758678004165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 758678004166 active site 758678004167 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 758678004168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678004169 active site 758678004170 uracil transporter; Provisional; Region: PRK10720 758678004171 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 758678004172 active site 758678004173 putative catalytic site [active] 758678004174 phosphate binding site A [ion binding]; other site 758678004175 DNA binding site [nucleotide binding] 758678004176 metal binding site A [ion binding]; metal-binding site 758678004177 putative AP binding site [nucleotide binding]; other site 758678004178 putative metal binding site B [ion binding]; other site 758678004179 phosphate binding site B [ion binding]; other site 758678004180 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 758678004181 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 758678004182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758678004183 Carbonic anhydrase; Region: Pro_CA; smart00947 758678004184 active site clefts [active] 758678004185 zinc binding site [ion binding]; other site 758678004186 dimer interface [polypeptide binding]; other site 758678004187 potential frameshift: common BLAST hit: gi|153940544|ref|YP_001390830.1| molybdate ABC transporter periplasmic molybdate-binding protein 758678004188 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 758678004189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758678004190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004191 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 758678004192 putative PBP binding loops; other site 758678004193 ABC-ATPase subunit interface; other site 758678004194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678004195 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 758678004196 Walker A/P-loop; other site 758678004197 ATP binding site [chemical binding]; other site 758678004198 Q-loop/lid; other site 758678004199 ABC transporter signature motif; other site 758678004200 Walker B; other site 758678004201 D-loop; other site 758678004202 H-loop/switch region; other site 758678004203 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 758678004204 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 758678004205 active site 758678004206 nucleophile elbow; other site 758678004207 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 758678004208 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 758678004209 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 758678004210 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 758678004211 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 758678004212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678004213 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 758678004214 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 758678004215 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 758678004216 B12 binding site [chemical binding]; other site 758678004217 cobalt ligand [ion binding]; other site 758678004218 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 758678004219 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 758678004220 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 758678004221 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 758678004222 Walker A/P-loop; other site 758678004223 ATP binding site [chemical binding]; other site 758678004224 Q-loop/lid; other site 758678004225 ABC transporter signature motif; other site 758678004226 Walker B; other site 758678004227 D-loop; other site 758678004228 H-loop/switch region; other site 758678004229 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 758678004230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004231 dimer interface [polypeptide binding]; other site 758678004232 conserved gate region; other site 758678004233 ABC-ATPase subunit interface; other site 758678004234 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758678004235 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758678004236 MORN repeat; Region: MORN; cl14787 758678004237 MORN repeat; Region: MORN; cl14787 758678004238 MORN repeat; Region: MORN; cl14787 758678004239 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758678004240 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 758678004241 active site 758678004242 FMN binding site [chemical binding]; other site 758678004243 substrate binding site [chemical binding]; other site 758678004244 putative catalytic residue [active] 758678004245 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 758678004246 dimer interface [polypeptide binding]; other site 758678004247 active site 758678004248 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 758678004249 DNA topoisomerase III; Provisional; Region: PRK07726 758678004250 active site 758678004251 putative interdomain interaction site [polypeptide binding]; other site 758678004252 putative metal-binding site [ion binding]; other site 758678004253 putative nucleotide binding site [chemical binding]; other site 758678004254 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 758678004255 domain I; other site 758678004256 DNA binding groove [nucleotide binding] 758678004257 phosphate binding site [ion binding]; other site 758678004258 domain II; other site 758678004259 domain III; other site 758678004260 nucleotide binding site [chemical binding]; other site 758678004261 catalytic site [active] 758678004262 domain IV; other site 758678004263 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 758678004264 Walker A/P-loop; other site 758678004265 ATP binding site [chemical binding]; other site 758678004266 Q-loop/lid; other site 758678004267 ABC transporter signature motif; other site 758678004268 Walker B; other site 758678004269 D-loop; other site 758678004270 H-loop/switch region; other site 758678004271 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 758678004272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758678004273 active site 758678004274 catalytic tetrad [active] 758678004275 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678004276 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 758678004277 putative deacylase active site [active] 758678004278 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678004279 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678004280 Walker A/P-loop; other site 758678004281 ATP binding site [chemical binding]; other site 758678004282 Q-loop/lid; other site 758678004283 ABC transporter signature motif; other site 758678004284 Walker B; other site 758678004285 D-loop; other site 758678004286 H-loop/switch region; other site 758678004287 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678004288 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678004289 FtsX-like permease family; Region: FtsX; pfam02687 758678004290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678004291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678004292 Protein of unknown function (DUF523); Region: DUF523; pfam04463 758678004293 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 758678004294 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 758678004295 Walker A/P-loop; other site 758678004296 ATP binding site [chemical binding]; other site 758678004297 Q-loop/lid; other site 758678004298 ABC transporter signature motif; other site 758678004299 Walker B; other site 758678004300 D-loop; other site 758678004301 H-loop/switch region; other site 758678004302 TOBE domain; Region: TOBE; pfam03459 758678004303 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758678004304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004305 dimer interface [polypeptide binding]; other site 758678004306 conserved gate region; other site 758678004307 putative PBP binding loops; other site 758678004308 ABC-ATPase subunit interface; other site 758678004309 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758678004310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004311 dimer interface [polypeptide binding]; other site 758678004312 conserved gate region; other site 758678004313 putative PBP binding loops; other site 758678004314 ABC-ATPase subunit interface; other site 758678004315 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 758678004316 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 758678004317 NAD binding site [chemical binding]; other site 758678004318 dimer interface [polypeptide binding]; other site 758678004319 substrate binding site [chemical binding]; other site 758678004320 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678004321 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758678004322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678004323 DNA-binding site [nucleotide binding]; DNA binding site 758678004324 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758678004325 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 758678004326 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 758678004327 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 758678004328 gating phenylalanine in ion channel; other site 758678004329 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 758678004330 dimerization interface [polypeptide binding]; other site 758678004331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678004332 MarR family; Region: MarR_2; pfam12802 758678004333 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 758678004334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758678004335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758678004336 active site 758678004337 metal binding site [ion binding]; metal-binding site 758678004338 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 758678004339 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 758678004340 DNA binding site [nucleotide binding] 758678004341 active site 758678004342 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 758678004343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678004344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678004345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678004346 hypothetical protein; Provisional; Region: PRK02399 758678004347 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 758678004348 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 758678004349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678004350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678004351 non-specific DNA binding site [nucleotide binding]; other site 758678004352 salt bridge; other site 758678004353 sequence-specific DNA binding site [nucleotide binding]; other site 758678004354 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 758678004355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678004356 putative substrate translocation pore; other site 758678004357 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 758678004358 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 758678004359 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 758678004360 HDOD domain; Region: HDOD; pfam08668 758678004361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678004362 Zn2+ binding site [ion binding]; other site 758678004363 Mg2+ binding site [ion binding]; other site 758678004364 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758678004365 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 758678004366 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 758678004367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678004368 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 758678004369 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 758678004370 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 758678004371 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758678004372 active site 758678004373 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678004374 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678004375 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 758678004376 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678004377 ligand binding site [chemical binding]; other site 758678004378 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758678004379 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678004380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678004381 Walker A/P-loop; other site 758678004382 ATP binding site [chemical binding]; other site 758678004383 Q-loop/lid; other site 758678004384 ABC transporter signature motif; other site 758678004385 Walker B; other site 758678004386 D-loop; other site 758678004387 H-loop/switch region; other site 758678004388 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758678004389 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 758678004390 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758678004391 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758678004392 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 758678004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 758678004394 Predicted transcriptional regulator [Transcription]; Region: COG2378 758678004395 HTH domain; Region: HTH_11; pfam08279 758678004396 WYL domain; Region: WYL; pfam13280 758678004397 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 758678004398 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 758678004399 active site 758678004400 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 758678004401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678004402 FeS/SAM binding site; other site 758678004403 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 758678004404 active site 758678004405 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 758678004406 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 758678004407 Ligand Binding Site [chemical binding]; other site 758678004408 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678004409 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678004410 dimer interface [polypeptide binding]; other site 758678004411 putative CheW interface [polypeptide binding]; other site 758678004412 Protein of unknown function (DUF975); Region: DUF975; cl10504 758678004413 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 758678004414 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 758678004415 DNA binding residues [nucleotide binding] 758678004416 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 758678004417 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 758678004418 intersubunit interface [polypeptide binding]; other site 758678004419 active site 758678004420 catalytic residue [active] 758678004421 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758678004422 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 758678004423 substrate binding site [chemical binding]; other site 758678004424 dimer interface [polypeptide binding]; other site 758678004425 ATP binding site [chemical binding]; other site 758678004426 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 758678004427 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 758678004428 dimer interface [polypeptide binding]; other site 758678004429 motif 1; other site 758678004430 active site 758678004431 motif 2; other site 758678004432 motif 3; other site 758678004433 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 758678004434 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 758678004435 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 758678004436 histidinol dehydrogenase; Region: hisD; TIGR00069 758678004437 NAD binding site [chemical binding]; other site 758678004438 dimerization interface [polypeptide binding]; other site 758678004439 product binding site; other site 758678004440 substrate binding site [chemical binding]; other site 758678004441 zinc binding site [ion binding]; other site 758678004442 catalytic residues [active] 758678004443 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 758678004444 putative active site pocket [active] 758678004445 4-fold oligomerization interface [polypeptide binding]; other site 758678004446 metal binding residues [ion binding]; metal-binding site 758678004447 3-fold/trimer interface [polypeptide binding]; other site 758678004448 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 758678004449 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 758678004450 putative active site [active] 758678004451 oxyanion strand; other site 758678004452 catalytic triad [active] 758678004453 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 758678004454 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 758678004455 catalytic residues [active] 758678004456 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 758678004457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678004458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678004459 homodimer interface [polypeptide binding]; other site 758678004460 catalytic residue [active] 758678004461 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 758678004462 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 758678004463 substrate binding site [chemical binding]; other site 758678004464 glutamase interaction surface [polypeptide binding]; other site 758678004465 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 758678004466 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 758678004467 metal binding site [ion binding]; metal-binding site 758678004468 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 758678004469 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 758678004470 CPxP motif; other site 758678004471 putative inner membrane protein; Provisional; Region: PRK11099 758678004472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758678004473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678004474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758678004475 dimerization interface [polypeptide binding]; other site 758678004476 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678004477 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758678004478 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 758678004479 Sulphur transport; Region: Sulf_transp; pfam04143 758678004480 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 758678004481 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 758678004482 Walker A/P-loop; other site 758678004483 ATP binding site [chemical binding]; other site 758678004484 Q-loop/lid; other site 758678004485 ABC transporter signature motif; other site 758678004486 Walker B; other site 758678004487 D-loop; other site 758678004488 H-loop/switch region; other site 758678004489 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 758678004490 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678004491 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 758678004492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678004493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678004494 active site 758678004495 phosphorylation site [posttranslational modification] 758678004496 intermolecular recognition site; other site 758678004497 dimerization interface [polypeptide binding]; other site 758678004498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678004499 DNA binding site [nucleotide binding] 758678004500 arginine deiminase; Provisional; Region: PRK01388 758678004501 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 758678004502 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 758678004503 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 758678004504 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 758678004505 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 758678004506 HD domain; Region: HD_3; pfam13023 758678004507 YmaF family; Region: YmaF; pfam12788 758678004508 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 758678004509 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 758678004510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678004511 ATP binding site [chemical binding]; other site 758678004512 putative Mg++ binding site [ion binding]; other site 758678004513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678004514 nucleotide binding region [chemical binding]; other site 758678004515 ATP-binding site [chemical binding]; other site 758678004516 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 758678004517 synthetase active site [active] 758678004518 NTP binding site [chemical binding]; other site 758678004519 metal binding site [ion binding]; metal-binding site 758678004520 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 758678004521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678004522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678004523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678004524 Walker A/P-loop; other site 758678004525 ATP binding site [chemical binding]; other site 758678004526 Q-loop/lid; other site 758678004527 ABC transporter signature motif; other site 758678004528 Walker B; other site 758678004529 D-loop; other site 758678004530 H-loop/switch region; other site 758678004531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678004532 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 758678004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678004534 Walker A/P-loop; other site 758678004535 ATP binding site [chemical binding]; other site 758678004536 Q-loop/lid; other site 758678004537 ABC transporter signature motif; other site 758678004538 Walker B; other site 758678004539 D-loop; other site 758678004540 H-loop/switch region; other site 758678004541 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758678004542 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758678004543 DNA binding site [nucleotide binding] 758678004544 domain linker motif; other site 758678004545 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 758678004546 putative dimerization interface [polypeptide binding]; other site 758678004547 putative ligand binding site [chemical binding]; other site 758678004548 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 758678004549 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678004550 nucleotide binding site [chemical binding]; other site 758678004551 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 758678004552 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 758678004553 Ca binding site [ion binding]; other site 758678004554 active site 758678004555 catalytic site [active] 758678004556 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678004557 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 758678004558 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678004559 active site turn [active] 758678004560 phosphorylation site [posttranslational modification] 758678004561 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 758678004562 putative catalytic site [active] 758678004563 putative metal binding site [ion binding]; other site 758678004564 putative phosphate binding site [ion binding]; other site 758678004565 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 758678004566 Domain of unknown function DUF; Region: DUF204; pfam02659 758678004567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 758678004568 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 758678004569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678004570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678004571 dimer interface [polypeptide binding]; other site 758678004572 phosphorylation site [posttranslational modification] 758678004573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678004574 ATP binding site [chemical binding]; other site 758678004575 Mg2+ binding site [ion binding]; other site 758678004576 G-X-G motif; other site 758678004577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678004578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678004579 active site 758678004580 phosphorylation site [posttranslational modification] 758678004581 intermolecular recognition site; other site 758678004582 dimerization interface [polypeptide binding]; other site 758678004583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678004584 DNA binding site [nucleotide binding] 758678004585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678004586 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 758678004587 putative substrate translocation pore; other site 758678004588 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758678004589 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 758678004590 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758678004591 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678004592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678004593 DNA binding residues [nucleotide binding] 758678004594 YvrJ protein family; Region: YvrJ; pfam12841 758678004595 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 758678004596 FAD binding site [chemical binding]; other site 758678004597 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 758678004598 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 758678004599 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 758678004600 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 758678004601 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 758678004602 substrate binding pocket [chemical binding]; other site 758678004603 dimer interface [polypeptide binding]; other site 758678004604 inhibitor binding site; inhibition site 758678004605 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 758678004606 B12 binding site [chemical binding]; other site 758678004607 hypothetical protein; Provisional; Region: PRK12705 758678004608 RNA polymerase factor sigma-70; Validated; Region: PRK06811 758678004609 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 758678004610 DNA binding residues [nucleotide binding] 758678004611 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 758678004612 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 758678004613 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 758678004614 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 758678004615 tetramer interface [polypeptide binding]; other site 758678004616 TPP-binding site [chemical binding]; other site 758678004617 heterodimer interface [polypeptide binding]; other site 758678004618 phosphorylation loop region [posttranslational modification] 758678004619 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 758678004620 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 758678004621 alpha subunit interface [polypeptide binding]; other site 758678004622 TPP binding site [chemical binding]; other site 758678004623 heterodimer interface [polypeptide binding]; other site 758678004624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758678004625 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 758678004626 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 758678004627 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758678004628 E3 interaction surface; other site 758678004629 lipoyl attachment site [posttranslational modification]; other site 758678004630 e3 binding domain; Region: E3_binding; pfam02817 758678004631 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 758678004632 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 758678004633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678004634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678004635 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758678004636 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 758678004637 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 758678004638 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 758678004639 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 758678004640 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 758678004641 Walker A/P-loop; other site 758678004642 ATP binding site [chemical binding]; other site 758678004643 Q-loop/lid; other site 758678004644 ABC transporter signature motif; other site 758678004645 Walker B; other site 758678004646 D-loop; other site 758678004647 H-loop/switch region; other site 758678004648 FOG: CBS domain [General function prediction only]; Region: COG0517 758678004649 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 758678004650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678004651 dimer interface [polypeptide binding]; other site 758678004652 conserved gate region; other site 758678004653 putative PBP binding loops; other site 758678004654 ABC-ATPase subunit interface; other site 758678004655 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 758678004656 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 758678004657 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 758678004658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678004659 catalytic residue [active] 758678004660 homoserine kinase; Provisional; Region: PRK01212 758678004661 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 758678004662 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 758678004663 aspartate kinase; Reviewed; Region: PRK09034 758678004664 nucleotide binding site [chemical binding]; other site 758678004665 substrate binding site [chemical binding]; other site 758678004666 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 758678004667 allosteric regulatory residue; other site 758678004668 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 758678004669 homoserine dehydrogenase; Provisional; Region: PRK06349 758678004670 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 758678004671 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 758678004672 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 758678004673 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758678004674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678004675 putative active site [active] 758678004676 heme pocket [chemical binding]; other site 758678004677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678004678 Walker A motif; other site 758678004679 ATP binding site [chemical binding]; other site 758678004680 Walker B motif; other site 758678004681 arginine finger; other site 758678004682 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758678004683 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758678004684 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 758678004685 putative active site [active] 758678004686 metal binding site [ion binding]; metal-binding site 758678004687 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 758678004688 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 758678004689 FAD binding pocket [chemical binding]; other site 758678004690 FAD binding motif [chemical binding]; other site 758678004691 phosphate binding motif [ion binding]; other site 758678004692 beta-alpha-beta structure motif; other site 758678004693 NAD binding pocket [chemical binding]; other site 758678004694 Iron coordination center [ion binding]; other site 758678004695 putative oxidoreductase; Provisional; Region: PRK12831 758678004696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678004697 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758678004698 PAS domain; Region: PAS; smart00091 758678004699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678004700 Walker A motif; other site 758678004701 ATP binding site [chemical binding]; other site 758678004702 Walker B motif; other site 758678004703 arginine finger; other site 758678004704 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758678004705 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 758678004706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758678004707 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 758678004708 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 758678004709 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 758678004710 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 758678004711 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678004712 Hemerythrin-like domain; Region: Hr-like; cd12108 758678004713 Fe binding site [ion binding]; other site 758678004714 alanine racemase; Reviewed; Region: alr; PRK00053 758678004715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 758678004716 active site 758678004717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678004718 dimer interface [polypeptide binding]; other site 758678004719 substrate binding site [chemical binding]; other site 758678004720 catalytic residues [active] 758678004721 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678004722 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678004723 dimer interface [polypeptide binding]; other site 758678004724 putative CheW interface [polypeptide binding]; other site 758678004725 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 758678004726 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758678004727 Protein of unknown function (DUF975); Region: DUF975; cl10504 758678004728 short chain dehydrogenase; Provisional; Region: PRK06701 758678004729 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 758678004730 NAD binding site [chemical binding]; other site 758678004731 metal binding site [ion binding]; metal-binding site 758678004732 active site 758678004733 KWG Leptospira; Region: KWG; pfam07656 758678004734 KWG Leptospira; Region: KWG; pfam07656 758678004735 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 758678004736 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 758678004737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678004738 ATP binding site [chemical binding]; other site 758678004739 putative Mg++ binding site [ion binding]; other site 758678004740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678004741 nucleotide binding region [chemical binding]; other site 758678004742 ATP-binding site [chemical binding]; other site 758678004743 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 758678004744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758678004745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678004746 putative substrate translocation pore; other site 758678004747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678004748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678004749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678004750 Walker A/P-loop; other site 758678004751 ATP binding site [chemical binding]; other site 758678004752 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 758678004753 active site 758678004754 catalytic site [active] 758678004755 substrate binding site [chemical binding]; other site 758678004756 Predicted secreted protein [Function unknown]; Region: COG4086 758678004757 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 758678004758 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758678004759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678004760 S-adenosylmethionine binding site [chemical binding]; other site 758678004761 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 758678004762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678004763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678004764 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758678004765 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 758678004766 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 758678004767 putative substrate binding site [chemical binding]; other site 758678004768 putative ATP binding site [chemical binding]; other site 758678004769 Putative amidase domain; Region: Amidase_6; pfam12671 758678004770 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 758678004771 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758678004772 substrate binding site [chemical binding]; other site 758678004773 ATP binding site [chemical binding]; other site 758678004774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678004775 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 758678004776 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 758678004777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758678004778 DNA-binding site [nucleotide binding]; DNA binding site 758678004779 RNA-binding motif; other site 758678004780 Cache domain; Region: Cache_1; pfam02743 758678004781 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758678004782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678004783 dimer interface [polypeptide binding]; other site 758678004784 putative CheW interface [polypeptide binding]; other site 758678004785 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 758678004786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678004787 Pecanex protein (C-terminus); Region: Pecanex_C; pfam05041 758678004788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678004789 ABC transporter; Region: ABC_tran_2; pfam12848 758678004790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678004791 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 758678004792 putative deacylase active site [active] 758678004793 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 758678004794 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758678004795 4Fe-4S binding domain; Region: Fer4_6; pfam12837 758678004796 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 758678004797 Response regulator receiver domain; Region: Response_reg; pfam00072 758678004798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678004799 active site 758678004800 phosphorylation site [posttranslational modification] 758678004801 intermolecular recognition site; other site 758678004802 dimerization interface [polypeptide binding]; other site 758678004803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 758678004804 DEAD-like helicases superfamily; Region: DEXDc; smart00487 758678004805 ATP binding site [chemical binding]; other site 758678004806 putative Mg++ binding site [ion binding]; other site 758678004807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678004808 nucleotide binding region [chemical binding]; other site 758678004809 ATP-binding site [chemical binding]; other site 758678004810 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 758678004811 S1 domain; Region: S1_2; pfam13509 758678004812 S1 domain; Region: S1_2; pfam13509 758678004813 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 758678004814 RNA binding site [nucleotide binding]; other site 758678004815 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 758678004816 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758678004817 ATP binding site [chemical binding]; other site 758678004818 Mg++ binding site [ion binding]; other site 758678004819 motif III; other site 758678004820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678004821 nucleotide binding region [chemical binding]; other site 758678004822 ATP-binding site [chemical binding]; other site 758678004823 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 758678004824 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 758678004825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004828 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004829 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 758678004830 Leucine rich repeat; Region: LRR_8; pfam13855 758678004831 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004832 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004833 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678004834 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 758678004835 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678004836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678004837 active site 758678004838 phosphorylation site [posttranslational modification] 758678004839 intermolecular recognition site; other site 758678004840 dimerization interface [polypeptide binding]; other site 758678004841 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 758678004842 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 758678004843 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 758678004844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 758678004845 Nucleoside recognition; Region: Gate; pfam07670 758678004846 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 758678004847 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 758678004848 LexA repressor; Validated; Region: PRK00215 758678004849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678004850 putative Zn2+ binding site [ion binding]; other site 758678004851 putative DNA binding site [nucleotide binding]; other site 758678004852 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 758678004853 Catalytic site [active] 758678004854 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 758678004855 Aluminium resistance protein; Region: Alum_res; pfam06838 758678004856 bacterial Hfq-like; Region: Hfq; cd01716 758678004857 hexamer interface [polypeptide binding]; other site 758678004858 Sm1 motif; other site 758678004859 RNA binding site [nucleotide binding]; other site 758678004860 Sm2 motif; other site 758678004861 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 758678004862 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 758678004863 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 758678004864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678004865 ATP binding site [chemical binding]; other site 758678004866 Mg2+ binding site [ion binding]; other site 758678004867 G-X-G motif; other site 758678004868 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 758678004869 ATP binding site [chemical binding]; other site 758678004870 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 758678004871 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 758678004872 MutS domain I; Region: MutS_I; pfam01624 758678004873 MutS domain II; Region: MutS_II; pfam05188 758678004874 MutS domain III; Region: MutS_III; pfam05192 758678004875 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 758678004876 Walker A/P-loop; other site 758678004877 ATP binding site [chemical binding]; other site 758678004878 Q-loop/lid; other site 758678004879 ABC transporter signature motif; other site 758678004880 Walker B; other site 758678004881 D-loop; other site 758678004882 H-loop/switch region; other site 758678004883 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 758678004884 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 758678004885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678004886 FeS/SAM binding site; other site 758678004887 TRAM domain; Region: TRAM; pfam01938 758678004888 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 758678004889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678004890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678004891 homodimer interface [polypeptide binding]; other site 758678004892 catalytic residue [active] 758678004893 aspartate aminotransferase; Provisional; Region: PRK07568 758678004894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678004895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678004896 homodimer interface [polypeptide binding]; other site 758678004897 catalytic residue [active] 758678004898 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678004899 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 758678004900 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 758678004901 LytB protein; Region: LYTB; cl00507 758678004902 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 758678004903 RNA binding site [nucleotide binding]; other site 758678004904 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 758678004905 RNA binding site [nucleotide binding]; other site 758678004906 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 758678004907 RNA binding site [nucleotide binding]; other site 758678004908 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 758678004909 RNA binding site [nucleotide binding]; other site 758678004910 domain interface; other site 758678004911 cytidylate kinase; Provisional; Region: cmk; PRK00023 758678004912 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 758678004913 CMP-binding site; other site 758678004914 The sites determining sugar specificity; other site 758678004915 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 758678004916 homotrimer interaction site [polypeptide binding]; other site 758678004917 active site 758678004918 flavoprotein, HI0933 family; Region: TIGR00275 758678004919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678004920 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 758678004921 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 758678004922 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 758678004923 NAD(P) binding site [chemical binding]; other site 758678004924 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678004925 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678004926 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678004927 putative active site [active] 758678004928 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 758678004929 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678004930 RNA binding surface [nucleotide binding]; other site 758678004931 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 758678004932 active site 758678004933 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 758678004934 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 758678004935 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 758678004936 DXD motif; other site 758678004937 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 758678004938 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 758678004939 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 758678004940 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758678004941 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758678004942 catalytic residues [active] 758678004943 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758678004944 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 758678004945 putative active site [active] 758678004946 catalytic triad [active] 758678004947 dimer interface [polypeptide binding]; other site 758678004948 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758678004949 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758678004950 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 758678004951 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678004952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678004953 Coenzyme A binding pocket [chemical binding]; other site 758678004954 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 758678004955 active site residue [active] 758678004956 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 758678004957 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 758678004958 dimer interface [polypeptide binding]; other site 758678004959 [2Fe-2S] cluster binding site [ion binding]; other site 758678004960 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 758678004961 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678004962 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 758678004963 Putative Fe-S cluster; Region: FeS; cl17515 758678004964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678004965 putative active site [active] 758678004966 heme pocket [chemical binding]; other site 758678004967 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 758678004968 4Fe-4S binding domain; Region: Fer4; pfam00037 758678004969 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 758678004970 Putative Fe-S cluster; Region: FeS; cl17515 758678004971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678004972 putative active site [active] 758678004973 Hydrogenase formation hypA family; Region: HypD; pfam01924 758678004974 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 758678004975 HupF/HypC family; Region: HupF_HypC; pfam01455 758678004976 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 758678004977 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 758678004978 nickel binding site [ion binding]; other site 758678004979 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 758678004980 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 758678004981 TraX protein; Region: TraX; pfam05857 758678004982 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 758678004983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758678004984 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 758678004985 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 758678004986 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758678004987 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758678004988 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 758678004989 IMP binding site; other site 758678004990 dimer interface [polypeptide binding]; other site 758678004991 interdomain contacts; other site 758678004992 partial ornithine binding site; other site 758678004993 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 758678004994 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 758678004995 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 758678004996 catalytic site [active] 758678004997 subunit interface [polypeptide binding]; other site 758678004998 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758678004999 potential frameshift: common BLAST hit: gi|331270401|ref|YP_004396893.1| ISBma2, transposase 758678005000 Transposase domain (DUF772); Region: DUF772; pfam05598 758678005001 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 758678005002 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 758678005003 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 758678005004 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 758678005005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 758678005006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678005007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678005008 Walker A/P-loop; other site 758678005009 ATP binding site [chemical binding]; other site 758678005010 Q-loop/lid; other site 758678005011 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678005012 ABC transporter signature motif; other site 758678005013 ABC transporter; Region: ABC_tran_2; pfam12848 758678005014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678005015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758678005016 catalytic loop [active] 758678005017 iron binding site [ion binding]; other site 758678005018 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 758678005019 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 758678005020 4Fe-4S binding domain; Region: Fer4; pfam00037 758678005021 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 758678005022 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 758678005023 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 758678005024 dimer interface [polypeptide binding]; other site 758678005025 [2Fe-2S] cluster binding site [ion binding]; other site 758678005026 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 758678005027 SLBB domain; Region: SLBB; pfam10531 758678005028 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 758678005029 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 758678005030 4Fe-4S binding domain; Region: Fer4; pfam00037 758678005031 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 758678005032 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 758678005033 putative dimer interface [polypeptide binding]; other site 758678005034 [2Fe-2S] cluster binding site [ion binding]; other site 758678005035 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 758678005036 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 758678005037 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758678005038 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758678005039 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 758678005040 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 758678005041 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 758678005042 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 758678005043 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 758678005044 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 758678005045 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 758678005046 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 758678005047 putative catalytic site [active] 758678005048 putative metal binding site [ion binding]; other site 758678005049 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 758678005050 putative catalytic site [active] 758678005051 putative phosphate binding site [ion binding]; other site 758678005052 putative phosphate binding site [ion binding]; other site 758678005053 putative metal binding site [ion binding]; other site 758678005054 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 758678005055 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 758678005056 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 758678005057 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 758678005058 purine nucleoside phosphorylase; Provisional; Region: PRK08202 758678005059 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 758678005060 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 758678005061 Int/Topo IB signature motif; other site 758678005062 active site 758678005063 stage II sporulation protein M; Region: spo_II_M; TIGR02831 758678005064 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 758678005065 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 758678005066 dimer interface [polypeptide binding]; other site 758678005067 ADP-ribose binding site [chemical binding]; other site 758678005068 active site 758678005069 nudix motif; other site 758678005070 metal binding site [ion binding]; metal-binding site 758678005071 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 758678005072 DNA binding site [nucleotide binding] 758678005073 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 758678005074 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678005075 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678005076 active site 758678005077 metal binding site [ion binding]; metal-binding site 758678005078 Bacterial SH3 domain; Region: SH3_3; pfam08239 758678005079 Haemolysin XhlA; Region: XhlA; pfam10779 758678005080 Phage tail protein; Region: Sipho_tail; cl17486 758678005081 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 758678005082 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 758678005083 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 758678005084 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 758678005085 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 758678005086 oligomerization interface [polypeptide binding]; other site 758678005087 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 758678005088 Phage capsid family; Region: Phage_capsid; pfam05065 758678005089 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 758678005090 oligomer interface [polypeptide binding]; other site 758678005091 active site residues [active] 758678005092 Phage portal protein; Region: Phage_portal; pfam04860 758678005093 Phage-related protein [Function unknown]; Region: COG4695 758678005094 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 758678005095 Phage terminase, small subunit; Region: Terminase_4; pfam05119 758678005096 Predicted ATPase [General function prediction only]; Region: COG5293 758678005097 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 758678005098 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 758678005099 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 758678005100 putative active site [active] 758678005101 catalytic site [active] 758678005102 putative metal binding site [ion binding]; other site 758678005103 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 758678005104 metal-binding site [ion binding] 758678005105 YcfA-like protein; Region: YcfA; pfam07927 758678005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678005107 non-specific DNA binding site [nucleotide binding]; other site 758678005108 salt bridge; other site 758678005109 sequence-specific DNA binding site [nucleotide binding]; other site 758678005110 Helix-turn-helix domain; Region: HTH_36; pfam13730 758678005111 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758678005112 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 758678005113 active site 758678005114 metal binding site [ion binding]; metal-binding site 758678005115 Helix-turn-helix domain; Region: HTH_36; pfam13730 758678005116 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 758678005117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758678005118 active site 758678005119 Int/Topo IB signature motif; other site 758678005120 DNA binding site [nucleotide binding] 758678005121 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 758678005122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005123 active site 758678005124 phosphorylation site [posttranslational modification] 758678005125 intermolecular recognition site; other site 758678005126 dimerization interface [polypeptide binding]; other site 758678005127 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 758678005128 Homoserine O-succinyltransferase; Region: HTS; pfam04204 758678005129 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 758678005130 conserved cys residue [active] 758678005131 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 758678005132 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 758678005133 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 758678005134 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 758678005135 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 758678005136 homodimer interface [polypeptide binding]; other site 758678005137 substrate-cofactor binding pocket; other site 758678005138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005139 catalytic residue [active] 758678005140 arginine repressor; Provisional; Region: argR; PRK00441 758678005141 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 758678005142 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 758678005143 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 758678005144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678005145 RNA binding surface [nucleotide binding]; other site 758678005146 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 758678005147 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 758678005148 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 758678005149 TPP-binding site; other site 758678005150 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758678005151 PYR/PP interface [polypeptide binding]; other site 758678005152 dimer interface [polypeptide binding]; other site 758678005153 TPP binding site [chemical binding]; other site 758678005154 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758678005155 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 758678005156 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 758678005157 substrate binding pocket [chemical binding]; other site 758678005158 chain length determination region; other site 758678005159 substrate-Mg2+ binding site; other site 758678005160 catalytic residues [active] 758678005161 aspartate-rich region 1; other site 758678005162 active site lid residues [active] 758678005163 aspartate-rich region 2; other site 758678005164 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 758678005165 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 758678005166 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 758678005167 generic binding surface I; other site 758678005168 generic binding surface II; other site 758678005169 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 758678005170 Asp23 family; Region: Asp23; pfam03780 758678005171 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 758678005172 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 758678005173 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 758678005174 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 758678005175 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 758678005176 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 758678005177 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 758678005178 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 758678005179 elongation factor P; Validated; Region: PRK00529 758678005180 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 758678005181 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 758678005182 RNA binding site [nucleotide binding]; other site 758678005183 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 758678005184 RNA binding site [nucleotide binding]; other site 758678005185 Dehydroquinase class II; Region: DHquinase_II; pfam01220 758678005186 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 758678005187 trimer interface [polypeptide binding]; other site 758678005188 active site 758678005189 dimer interface [polypeptide binding]; other site 758678005190 shikimate kinase; Reviewed; Region: aroK; PRK00131 758678005191 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 758678005192 ADP binding site [chemical binding]; other site 758678005193 magnesium binding site [ion binding]; other site 758678005194 putative shikimate binding site; other site 758678005195 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 758678005196 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 758678005197 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 758678005198 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 758678005199 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 758678005200 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 758678005201 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758678005202 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758678005203 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 758678005204 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 758678005205 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 758678005206 Walker A motif; other site 758678005207 ATP binding site [chemical binding]; other site 758678005208 Walker B motif; other site 758678005209 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 758678005210 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 758678005211 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 758678005212 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 758678005213 Domain of unknown function (DUF814); Region: DUF814; pfam05670 758678005214 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 758678005215 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 758678005216 dimerization interface 3.5A [polypeptide binding]; other site 758678005217 active site 758678005218 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 758678005219 nucleotide binding site/active site [active] 758678005220 HIT family signature motif; other site 758678005221 catalytic residue [active] 758678005222 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 758678005223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005224 catalytic residue [active] 758678005225 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758678005226 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758678005227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678005228 dimerization interface [polypeptide binding]; other site 758678005229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678005230 dimer interface [polypeptide binding]; other site 758678005231 putative CheW interface [polypeptide binding]; other site 758678005232 clostripain; Region: clostrip; TIGR02806 758678005233 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 758678005234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678005235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005236 active site 758678005237 phosphorylation site [posttranslational modification] 758678005238 intermolecular recognition site; other site 758678005239 dimerization interface [polypeptide binding]; other site 758678005240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678005241 DNA binding site [nucleotide binding] 758678005242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678005243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678005244 dimer interface [polypeptide binding]; other site 758678005245 phosphorylation site [posttranslational modification] 758678005246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678005247 ATP binding site [chemical binding]; other site 758678005248 Mg2+ binding site [ion binding]; other site 758678005249 G-X-G motif; other site 758678005250 methionine sulfoxide reductase A; Provisional; Region: PRK14054 758678005251 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678005252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005253 active site 758678005254 phosphorylation site [posttranslational modification] 758678005255 intermolecular recognition site; other site 758678005256 dimerization interface [polypeptide binding]; other site 758678005257 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678005258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005259 active site 758678005260 phosphorylation site [posttranslational modification] 758678005261 intermolecular recognition site; other site 758678005262 dimerization interface [polypeptide binding]; other site 758678005263 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 758678005264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678005265 dimerization interface [polypeptide binding]; other site 758678005266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678005267 dimer interface [polypeptide binding]; other site 758678005268 phosphorylation site [posttranslational modification] 758678005269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678005270 ATP binding site [chemical binding]; other site 758678005271 Mg2+ binding site [ion binding]; other site 758678005272 G-X-G motif; other site 758678005273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678005274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005275 active site 758678005276 phosphorylation site [posttranslational modification] 758678005277 intermolecular recognition site; other site 758678005278 dimerization interface [polypeptide binding]; other site 758678005279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678005280 DNA binding site [nucleotide binding] 758678005281 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 758678005282 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678005283 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 758678005284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678005285 Walker A/P-loop; other site 758678005286 ATP binding site [chemical binding]; other site 758678005287 Q-loop/lid; other site 758678005288 ABC transporter signature motif; other site 758678005289 Walker B; other site 758678005290 D-loop; other site 758678005291 H-loop/switch region; other site 758678005292 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678005293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678005294 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 758678005295 Walker A/P-loop; other site 758678005296 ATP binding site [chemical binding]; other site 758678005297 Q-loop/lid; other site 758678005298 ABC transporter signature motif; other site 758678005299 Walker B; other site 758678005300 D-loop; other site 758678005301 H-loop/switch region; other site 758678005302 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678005303 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 758678005304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678005305 Walker A/P-loop; other site 758678005306 ATP binding site [chemical binding]; other site 758678005307 Q-loop/lid; other site 758678005308 ABC transporter signature motif; other site 758678005309 Walker B; other site 758678005310 D-loop; other site 758678005311 H-loop/switch region; other site 758678005312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678005313 MarR family; Region: MarR; pfam01047 758678005314 MarR family; Region: MarR_2; cl17246 758678005315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 758678005316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678005317 Coenzyme A binding pocket [chemical binding]; other site 758678005318 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 758678005319 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 758678005320 ATP binding site [chemical binding]; other site 758678005321 substrate interface [chemical binding]; other site 758678005322 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 758678005323 MoaE interaction surface [polypeptide binding]; other site 758678005324 MoeB interaction surface [polypeptide binding]; other site 758678005325 thiocarboxylated glycine; other site 758678005326 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 758678005327 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 758678005328 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 758678005329 MOSC domain; Region: MOSC; pfam03473 758678005330 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 758678005331 trimer interface [polypeptide binding]; other site 758678005332 dimer interface [polypeptide binding]; other site 758678005333 putative active site [active] 758678005334 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 758678005335 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 758678005336 dimer interface [polypeptide binding]; other site 758678005337 putative functional site; other site 758678005338 putative MPT binding site; other site 758678005339 PBP superfamily domain; Region: PBP_like; pfam12727 758678005340 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 758678005341 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 758678005342 dimer interface [polypeptide binding]; other site 758678005343 putative functional site; other site 758678005344 putative MPT binding site; other site 758678005345 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 758678005346 MPT binding site; other site 758678005347 trimer interface [polypeptide binding]; other site 758678005348 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 758678005349 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 758678005350 Walker A/P-loop; other site 758678005351 ATP binding site [chemical binding]; other site 758678005352 Q-loop/lid; other site 758678005353 ABC transporter signature motif; other site 758678005354 Walker B; other site 758678005355 D-loop; other site 758678005356 H-loop/switch region; other site 758678005357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678005358 dimer interface [polypeptide binding]; other site 758678005359 conserved gate region; other site 758678005360 putative PBP binding loops; other site 758678005361 ABC-ATPase subunit interface; other site 758678005362 PBP superfamily domain; Region: PBP_like_2; pfam12849 758678005363 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 758678005364 putative efflux protein, MATE family; Region: matE; TIGR00797 758678005365 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758678005366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758678005367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678005368 FtsX-like permease family; Region: FtsX; pfam02687 758678005369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678005370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678005371 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 758678005372 Walker A/P-loop; other site 758678005373 ATP binding site [chemical binding]; other site 758678005374 Q-loop/lid; other site 758678005375 ABC transporter signature motif; other site 758678005376 Walker B; other site 758678005377 D-loop; other site 758678005378 H-loop/switch region; other site 758678005379 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678005380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678005381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678005382 Walker A/P-loop; other site 758678005383 ATP binding site [chemical binding]; other site 758678005384 Q-loop/lid; other site 758678005385 ABC transporter signature motif; other site 758678005386 Walker B; other site 758678005387 D-loop; other site 758678005388 H-loop/switch region; other site 758678005389 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 758678005390 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678005391 DNA binding residues [nucleotide binding] 758678005392 dimer interface [polypeptide binding]; other site 758678005393 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 758678005394 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678005395 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678005396 M6 family metalloprotease domain; Region: M6dom_TIGR03296 758678005397 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 758678005398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678005399 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 758678005400 Walker A motif; other site 758678005401 ATP binding site [chemical binding]; other site 758678005402 Walker B motif; other site 758678005403 arginine finger; other site 758678005404 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 758678005405 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758678005406 homotrimer interaction site [polypeptide binding]; other site 758678005407 putative active site [active] 758678005408 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 758678005409 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758678005410 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 758678005411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678005412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005413 homodimer interface [polypeptide binding]; other site 758678005414 catalytic residue [active] 758678005415 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 758678005416 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 758678005417 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678005418 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678005419 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678005420 M6 family metalloprotease domain; Region: M6dom_TIGR03296 758678005421 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 758678005422 dimerization interface [polypeptide binding]; other site 758678005423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678005424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678005425 dimer interface [polypeptide binding]; other site 758678005426 phosphorylation site [posttranslational modification] 758678005427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678005428 ATP binding site [chemical binding]; other site 758678005429 Mg2+ binding site [ion binding]; other site 758678005430 G-X-G motif; other site 758678005431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678005432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678005433 active site 758678005434 phosphorylation site [posttranslational modification] 758678005435 intermolecular recognition site; other site 758678005436 dimerization interface [polypeptide binding]; other site 758678005437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678005438 DNA binding site [nucleotide binding] 758678005439 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 758678005440 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 758678005441 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 758678005442 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 758678005443 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 758678005444 dimer interface [polypeptide binding]; other site 758678005445 active site 758678005446 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678005447 substrate binding site [chemical binding]; other site 758678005448 catalytic residue [active] 758678005449 Spore germination protein; Region: Spore_permease; cl17796 758678005450 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 758678005451 Spore germination protein; Region: Spore_permease; cl17796 758678005452 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 758678005453 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 758678005454 Spore germination protein; Region: Spore_permease; cl17796 758678005455 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 758678005456 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 758678005457 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 758678005458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678005459 FeS/SAM binding site; other site 758678005460 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 758678005461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678005462 binding surface 758678005463 TPR repeat; Region: TPR_11; pfam13414 758678005464 TPR motif; other site 758678005465 TPR repeat; Region: TPR_11; pfam13414 758678005466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678005467 binding surface 758678005468 TPR motif; other site 758678005469 TPR repeat; Region: TPR_11; pfam13414 758678005470 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 758678005471 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 758678005472 TrkA-C domain; Region: TrkA_C; pfam02080 758678005473 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 758678005474 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678005475 active site turn [active] 758678005476 phosphorylation site [posttranslational modification] 758678005477 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678005478 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 758678005479 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 758678005480 Ca binding site [ion binding]; other site 758678005481 active site 758678005482 catalytic site [active] 758678005483 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 758678005484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678005485 DNA-binding site [nucleotide binding]; DNA binding site 758678005486 UTRA domain; Region: UTRA; pfam07702 758678005487 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 758678005488 active site 758678005489 phosphorylation site [posttranslational modification] 758678005490 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 758678005491 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 758678005492 active site 758678005493 P-loop; other site 758678005494 phosphorylation site [posttranslational modification] 758678005495 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 758678005496 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 758678005497 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 758678005498 putative substrate binding site [chemical binding]; other site 758678005499 putative ATP binding site [chemical binding]; other site 758678005500 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 758678005501 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 758678005502 intersubunit interface [polypeptide binding]; other site 758678005503 active site 758678005504 zinc binding site [ion binding]; other site 758678005505 Na+ binding site [ion binding]; other site 758678005506 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758678005507 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758678005508 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758678005509 putative active site [active] 758678005510 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 758678005511 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758678005512 homotrimer interaction site [polypeptide binding]; other site 758678005513 putative active site [active] 758678005514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678005515 Radical SAM superfamily; Region: Radical_SAM; pfam04055 758678005516 FeS/SAM binding site; other site 758678005517 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 758678005518 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 758678005519 dimer interface [polypeptide binding]; other site 758678005520 active site 758678005521 metal binding site [ion binding]; metal-binding site 758678005522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678005523 dimerization interface [polypeptide binding]; other site 758678005524 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678005525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678005526 dimer interface [polypeptide binding]; other site 758678005527 putative CheW interface [polypeptide binding]; other site 758678005528 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 758678005529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 758678005530 dimer interface [polypeptide binding]; other site 758678005531 active site 758678005532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678005533 substrate binding site [chemical binding]; other site 758678005534 catalytic residue [active] 758678005535 ATP cone domain; Region: ATP-cone; pfam03477 758678005536 putative oxidoreductase; Provisional; Region: PRK11579 758678005537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758678005538 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758678005539 adenine phosphoribosyltransferase; Provisional; Region: PRK07322 758678005540 active site 758678005541 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758678005542 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678005543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678005544 metal binding site [ion binding]; metal-binding site 758678005545 active site 758678005546 I-site; other site 758678005547 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 758678005548 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 758678005549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678005550 Walker A motif; other site 758678005551 ATP binding site [chemical binding]; other site 758678005552 Walker B motif; other site 758678005553 arginine finger; other site 758678005554 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758678005555 DEAD-like helicases superfamily; Region: DEXDc; smart00487 758678005556 ATP binding site [chemical binding]; other site 758678005557 Mg++ binding site [ion binding]; other site 758678005558 motif III; other site 758678005559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678005560 nucleotide binding region [chemical binding]; other site 758678005561 ATP-binding site [chemical binding]; other site 758678005562 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 758678005563 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 758678005564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678005565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678005566 DNA-binding site [nucleotide binding]; DNA binding site 758678005567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678005568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005569 homodimer interface [polypeptide binding]; other site 758678005570 catalytic residue [active] 758678005571 EamA-like transporter family; Region: EamA; pfam00892 758678005572 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758678005573 aspartate aminotransferase; Provisional; Region: PRK06348 758678005574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678005575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005576 homodimer interface [polypeptide binding]; other site 758678005577 catalytic residue [active] 758678005578 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758678005579 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758678005580 Walker A/P-loop; other site 758678005581 ATP binding site [chemical binding]; other site 758678005582 Q-loop/lid; other site 758678005583 ABC transporter signature motif; other site 758678005584 Walker B; other site 758678005585 D-loop; other site 758678005586 H-loop/switch region; other site 758678005587 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758678005588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678005589 dimer interface [polypeptide binding]; other site 758678005590 conserved gate region; other site 758678005591 putative PBP binding loops; other site 758678005592 ABC-ATPase subunit interface; other site 758678005593 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758678005594 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758678005595 substrate binding pocket [chemical binding]; other site 758678005596 membrane-bound complex binding site; other site 758678005597 hinge residues; other site 758678005598 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 758678005599 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 758678005600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678005601 catalytic residue [active] 758678005602 Chloramphenicol acetyltransferase; Region: CAT; cl02008 758678005603 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 758678005604 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 758678005605 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 758678005606 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 758678005607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678005608 non-specific DNA binding site [nucleotide binding]; other site 758678005609 salt bridge; other site 758678005610 sequence-specific DNA binding site [nucleotide binding]; other site 758678005611 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 758678005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678005613 POT family; Region: PTR2; cl17359 758678005614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678005615 POT family; Region: PTR2; cl17359 758678005616 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758678005617 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758678005618 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 758678005619 active site 758678005620 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 758678005621 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 758678005622 nucleophilic elbow; other site 758678005623 catalytic triad; other site 758678005624 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 758678005625 putative FMN binding site [chemical binding]; other site 758678005626 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 758678005627 metal ion-dependent adhesion site (MIDAS); other site 758678005628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758678005629 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 758678005630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678005631 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 758678005632 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 758678005633 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 758678005634 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 758678005635 active site 758678005636 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 758678005637 active site 758678005638 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 758678005639 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 758678005640 putative trimer interface [polypeptide binding]; other site 758678005641 putative CoA binding site [chemical binding]; other site 758678005642 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 758678005643 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 758678005644 inhibitor-cofactor binding pocket; inhibition site 758678005645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005646 catalytic residue [active] 758678005647 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758678005648 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 758678005649 active site 758678005650 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 758678005651 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 758678005652 substrate binding site; other site 758678005653 metal-binding site 758678005654 Oligomer interface; other site 758678005655 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 758678005656 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 758678005657 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 758678005658 NAD binding site [chemical binding]; other site 758678005659 substrate binding site [chemical binding]; other site 758678005660 homodimer interface [polypeptide binding]; other site 758678005661 active site 758678005662 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 758678005663 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 758678005664 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 758678005665 PGAP1-like protein; Region: PGAP1; pfam07819 758678005666 VanZ like family; Region: VanZ; pfam04892 758678005667 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 758678005668 glycosyltransferase, MGT family; Region: MGT; TIGR01426 758678005669 active site 758678005670 TDP-binding site; other site 758678005671 acceptor substrate-binding pocket; other site 758678005672 homodimer interface [polypeptide binding]; other site 758678005673 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 758678005674 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 758678005675 cytosine deaminase; Provisional; Region: PRK09230 758678005676 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 758678005677 active site 758678005678 Radical SAM superfamily; Region: Radical_SAM; pfam04055 758678005679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678005680 FeS/SAM binding site; other site 758678005681 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 758678005682 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678005683 cofactor binding site; other site 758678005684 DNA binding site [nucleotide binding] 758678005685 substrate interaction site [chemical binding]; other site 758678005686 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 758678005687 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678005688 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678005689 AIPR protein; Region: AIPR; pfam10592 758678005690 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 758678005691 Z1 domain; Region: Z1; pfam10593 758678005692 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758678005693 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 758678005694 ATP binding site [chemical binding]; other site 758678005695 Mg2+ binding site [ion binding]; other site 758678005696 G-X-G motif; other site 758678005697 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 758678005698 Recombinase; Region: Recombinase; pfam07508 758678005699 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 758678005700 active site 758678005701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758678005702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758678005703 NAD(P) binding site [chemical binding]; other site 758678005704 active site 758678005705 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758678005706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758678005707 active site 758678005708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758678005709 active site 758678005710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758678005711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678005712 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758678005713 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 758678005714 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 758678005715 G1 box; other site 758678005716 putative GEF interaction site [polypeptide binding]; other site 758678005717 GTP/Mg2+ binding site [chemical binding]; other site 758678005718 Switch I region; other site 758678005719 G2 box; other site 758678005720 G3 box; other site 758678005721 Switch II region; other site 758678005722 G4 box; other site 758678005723 G5 box; other site 758678005724 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 758678005725 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 758678005726 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 758678005727 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 758678005728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678005729 Soluble P-type ATPase [General function prediction only]; Region: COG4087 758678005730 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 758678005731 putative homodimer interface [polypeptide binding]; other site 758678005732 putative homotetramer interface [polypeptide binding]; other site 758678005733 putative metal binding site [ion binding]; other site 758678005734 putative homodimer-homodimer interface [polypeptide binding]; other site 758678005735 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 758678005736 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 758678005737 Hexamer interface [polypeptide binding]; other site 758678005738 Putative hexagonal pore residue; other site 758678005739 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 758678005740 Propanediol utilisation protein PduL; Region: PduL; pfam06130 758678005741 Propanediol utilisation protein PduL; Region: PduL; pfam06130 758678005742 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 758678005743 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 758678005744 putative catalytic cysteine [active] 758678005745 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 758678005746 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 758678005747 Hexamer interface [polypeptide binding]; other site 758678005748 Hexagonal pore residue; other site 758678005749 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 758678005750 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 758678005751 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 758678005752 Hexamer/Pentamer interface [polypeptide binding]; other site 758678005753 central pore; other site 758678005754 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 758678005755 putative hexamer interface [polypeptide binding]; other site 758678005756 putative hexagonal pore; other site 758678005757 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 758678005758 Cell division protein FtsA; Region: FtsA; cl17206 758678005759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758678005760 nucleotide binding site [chemical binding]; other site 758678005761 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 758678005762 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 758678005763 G1 box; other site 758678005764 GTP/Mg2+ binding site [chemical binding]; other site 758678005765 G2 box; other site 758678005766 Switch I region; other site 758678005767 G3 box; other site 758678005768 Switch II region; other site 758678005769 G4 box; other site 758678005770 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 758678005771 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 758678005772 dimer interface [polypeptide binding]; other site 758678005773 active site 758678005774 glycine loop; other site 758678005775 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 758678005776 putative catalytic cysteine [active] 758678005777 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 758678005778 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 758678005779 Hexamer interface [polypeptide binding]; other site 758678005780 Hexagonal pore residue; other site 758678005781 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 758678005782 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 758678005783 Hexamer interface [polypeptide binding]; other site 758678005784 Hexagonal pore residue; other site 758678005785 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 758678005786 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 758678005787 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678005788 DNA binding residues [nucleotide binding] 758678005789 drug binding residues [chemical binding]; other site 758678005790 dimer interface [polypeptide binding]; other site 758678005791 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 758678005792 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758678005793 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 758678005794 putative active site [active] 758678005795 metal binding site [ion binding]; metal-binding site 758678005796 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 758678005797 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678005798 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 758678005799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678005800 putative substrate translocation pore; other site 758678005801 MarR family; Region: MarR_2; pfam12802 758678005802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678005803 Coenzyme A binding pocket [chemical binding]; other site 758678005804 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 758678005805 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 758678005806 Helix-turn-helix domain; Region: HTH_17; pfam12728 758678005807 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 758678005808 active site 758678005809 catalytic site [active] 758678005810 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 758678005811 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 758678005812 active site 758678005813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678005814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 758678005815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678005816 ATP binding site [chemical binding]; other site 758678005817 Mg2+ binding site [ion binding]; other site 758678005818 G-X-G motif; other site 758678005819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 758678005821 dimerization interface [polypeptide binding]; other site 758678005822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678005823 DNA binding site [nucleotide binding] 758678005824 TraB family; Region: TraB; cl12050 758678005825 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 758678005826 Zn binding site [ion binding]; other site 758678005827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678005828 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 758678005829 Walker A/P-loop; other site 758678005830 ATP binding site [chemical binding]; other site 758678005831 Q-loop/lid; other site 758678005832 ABC transporter signature motif; other site 758678005833 Walker B; other site 758678005834 D-loop; other site 758678005835 H-loop/switch region; other site 758678005836 putative oxidoreductase; Provisional; Region: PRK11445 758678005837 TrkA-N domain; Region: TrkA_N; pfam02254 758678005838 Predicted transcriptional regulator [Transcription]; Region: COG3655 758678005839 salt bridge; other site 758678005840 non-specific DNA binding site [nucleotide binding]; other site 758678005841 sequence-specific DNA binding site [nucleotide binding]; other site 758678005842 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 758678005843 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758678005844 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 758678005845 NAD(P) binding site [chemical binding]; other site 758678005846 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 758678005847 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 758678005848 Metal-binding active site; metal-binding site 758678005849 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 758678005850 active site 758678005851 dimer interface [polypeptide binding]; other site 758678005852 metal binding site [ion binding]; metal-binding site 758678005853 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758678005854 FtsX-like permease family; Region: FtsX; pfam02687 758678005855 FtsX-like permease family; Region: FtsX; pfam02687 758678005856 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678005857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678005858 Walker A/P-loop; other site 758678005859 ATP binding site [chemical binding]; other site 758678005860 Q-loop/lid; other site 758678005861 ABC transporter signature motif; other site 758678005862 Walker B; other site 758678005863 D-loop; other site 758678005864 H-loop/switch region; other site 758678005865 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 758678005866 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 758678005867 active site 758678005868 P-loop; other site 758678005869 phosphorylation site [posttranslational modification] 758678005870 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 758678005871 active site 758678005872 phosphorylation site [posttranslational modification] 758678005873 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 758678005874 active site 758678005875 intersubunit interactions; other site 758678005876 catalytic residue [active] 758678005877 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 758678005878 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 758678005879 active site 758678005880 substrate binding site [chemical binding]; other site 758678005881 trimer interface [polypeptide binding]; other site 758678005882 CoA binding site [chemical binding]; other site 758678005883 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 758678005884 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 758678005885 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 758678005886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678005887 POT family; Region: PTR2; cl17359 758678005888 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758678005889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678005890 S-adenosylmethionine binding site [chemical binding]; other site 758678005891 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 758678005892 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758678005893 phosphate binding site [ion binding]; other site 758678005894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758678005895 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758678005896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 758678005897 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 758678005898 DNA binding residues [nucleotide binding] 758678005899 dimer interface [polypeptide binding]; other site 758678005900 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 758678005901 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 758678005902 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 758678005903 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 758678005904 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 758678005905 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 758678005906 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 758678005907 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 758678005908 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 758678005909 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 758678005910 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758678005911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678005912 DNA-binding site [nucleotide binding]; DNA binding site 758678005913 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678005914 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678005915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678005916 homodimer interface [polypeptide binding]; other site 758678005917 catalytic residue [active] 758678005918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758678005919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758678005920 active site 758678005921 Staygreen protein; Region: Staygreen; pfam12638 758678005922 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 758678005923 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 758678005924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 758678005925 active site 758678005926 ATP binding site [chemical binding]; other site 758678005927 substrate binding site [chemical binding]; other site 758678005928 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 758678005929 substrate binding site [chemical binding]; other site 758678005930 activation loop (A-loop); other site 758678005931 activation loop (A-loop); other site 758678005932 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 758678005933 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678005934 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758678005935 Uncharacterized membrane protein [Function unknown]; Region: COG3949 758678005936 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758678005937 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 758678005938 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758678005939 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 758678005940 Ligand binding site [chemical binding]; other site 758678005941 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758678005942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758678005943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758678005944 active site 758678005945 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 758678005946 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678005947 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 758678005948 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678005949 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758678005950 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758678005951 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678005952 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 758678005953 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678005954 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 758678005955 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678005956 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678005957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678005958 nucleotide binding site [chemical binding]; other site 758678005959 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678005960 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678005961 dimer interface [polypeptide binding]; other site 758678005962 putative CheW interface [polypeptide binding]; other site 758678005963 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 758678005964 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 758678005965 active site 758678005966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678005967 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678005968 Coenzyme A binding pocket [chemical binding]; other site 758678005969 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 758678005970 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 758678005971 dimer interface [polypeptide binding]; other site 758678005972 active site 758678005973 Mn binding site [ion binding]; other site 758678005974 GntP family permease; Region: GntP_permease; pfam02447 758678005975 fructuronate transporter; Provisional; Region: PRK10034; cl15264 758678005976 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 758678005977 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 758678005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 758678005979 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758678005980 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 758678005981 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758678005982 CAAX protease self-immunity; Region: Abi; pfam02517 758678005983 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 758678005984 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 758678005985 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 758678005986 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 758678005987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678005988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678005989 WHG domain; Region: WHG; pfam13305 758678005990 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678005991 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 758678005992 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758678005993 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 758678005994 putative NAD(P) binding site [chemical binding]; other site 758678005995 catalytic Zn binding site [ion binding]; other site 758678005996 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 758678005997 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 758678005998 ACS interaction site; other site 758678005999 CODH interaction site; other site 758678006000 cubane metal cluster (B-cluster) [ion binding]; other site 758678006001 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 758678006002 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 758678006003 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 758678006004 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 758678006005 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678006006 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 758678006007 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 758678006008 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 758678006009 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 758678006010 P loop nucleotide binding; other site 758678006011 switch II; other site 758678006012 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 758678006013 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 758678006014 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 758678006015 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758678006016 ligand binding site [chemical binding]; other site 758678006017 flagellar motor protein MotA; Validated; Region: PRK08124 758678006018 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 758678006019 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678006020 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 758678006021 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678006022 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 758678006023 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 758678006024 OPT oligopeptide transporter protein; Region: OPT; cl14607 758678006025 putative oligopeptide transporter, OPT family; Region: TIGR00733 758678006026 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 758678006027 metal binding site [ion binding]; metal-binding site 758678006028 dimer interface [polypeptide binding]; other site 758678006029 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 758678006030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758678006031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678006032 catalytic residue [active] 758678006033 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 758678006034 oxidoreductase; Provisional; Region: PRK08017 758678006035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758678006036 NAD(P) binding site [chemical binding]; other site 758678006037 active site 758678006038 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 758678006039 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 758678006040 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 758678006041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678006042 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678006043 Walker A/P-loop; other site 758678006044 ATP binding site [chemical binding]; other site 758678006045 Q-loop/lid; other site 758678006046 ABC transporter signature motif; other site 758678006047 Walker B; other site 758678006048 D-loop; other site 758678006049 H-loop/switch region; other site 758678006050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678006051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678006052 Coenzyme A binding pocket [chemical binding]; other site 758678006053 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678006054 MarR family; Region: MarR_2; pfam12802 758678006055 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 758678006056 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 758678006057 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 758678006058 Predicted dehydrogenase [General function prediction only]; Region: COG0579 758678006059 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758678006060 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758678006061 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 758678006062 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758678006063 DNA binding residues [nucleotide binding] 758678006064 drug binding residues [chemical binding]; other site 758678006065 dimer interface [polypeptide binding]; other site 758678006066 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 758678006067 Amino acid permease; Region: AA_permease_2; pfam13520 758678006068 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 758678006069 putative ADP-ribose binding site [chemical binding]; other site 758678006070 putative active site [active] 758678006071 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 758678006072 MarR family; Region: MarR_2; cl17246 758678006073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678006074 TIGR03987 family protein; Region: TIGR03987 758678006075 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 758678006076 multimerization interface [polypeptide binding]; other site 758678006077 substrate binding site [chemical binding]; other site 758678006078 ATP binding site [chemical binding]; other site 758678006079 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 758678006080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758678006081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678006082 Coenzyme A binding pocket [chemical binding]; other site 758678006083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678006084 Mor transcription activator family; Region: Mor; cl02360 758678006085 AAA domain; Region: AAA_26; pfam13500 758678006086 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 758678006087 biotin synthase; Region: bioB; TIGR00433 758678006088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678006089 FeS/SAM binding site; other site 758678006090 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 758678006091 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 758678006092 hypothetical protein; Provisional; Region: PRK09272 758678006093 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678006094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758678006095 putative DNA binding site [nucleotide binding]; other site 758678006096 putative Zn2+ binding site [ion binding]; other site 758678006097 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 758678006098 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758678006099 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758678006100 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758678006101 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 758678006102 active site 758678006103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758678006104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678006105 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 758678006106 YmaF family; Region: YmaF; pfam12788 758678006107 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 758678006108 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 758678006109 active site 758678006110 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678006111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678006112 YmaF family; Region: YmaF; pfam12788 758678006113 hypothetical protein; Provisional; Region: PRK05802 758678006114 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 758678006115 FAD binding pocket [chemical binding]; other site 758678006116 FAD binding motif [chemical binding]; other site 758678006117 phosphate binding motif [ion binding]; other site 758678006118 beta-alpha-beta structure motif; other site 758678006119 NAD binding pocket [chemical binding]; other site 758678006120 Iron coordination center [ion binding]; other site 758678006121 methionine sulfoxide reductase B; Provisional; Region: PRK00222 758678006122 SelR domain; Region: SelR; pfam01641 758678006123 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 758678006124 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 758678006125 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 758678006126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678006127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678006128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678006129 Walker A/P-loop; other site 758678006130 ATP binding site [chemical binding]; other site 758678006131 Q-loop/lid; other site 758678006132 ABC transporter signature motif; other site 758678006133 Walker B; other site 758678006134 D-loop; other site 758678006135 H-loop/switch region; other site 758678006136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678006137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678006138 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678006139 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678006140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678006141 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 758678006142 Walker A/P-loop; other site 758678006143 ATP binding site [chemical binding]; other site 758678006144 Q-loop/lid; other site 758678006145 ABC transporter signature motif; other site 758678006146 Walker B; other site 758678006147 D-loop; other site 758678006148 H-loop/switch region; other site 758678006149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678006150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678006151 dimer interface [polypeptide binding]; other site 758678006152 phosphorylation site [posttranslational modification] 758678006153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678006154 ATP binding site [chemical binding]; other site 758678006155 Mg2+ binding site [ion binding]; other site 758678006156 G-X-G motif; other site 758678006157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678006158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678006159 active site 758678006160 phosphorylation site [posttranslational modification] 758678006161 intermolecular recognition site; other site 758678006162 dimerization interface [polypeptide binding]; other site 758678006163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678006164 DNA binding site [nucleotide binding] 758678006165 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 758678006166 active site 758678006167 catalytic site [active] 758678006168 substrate binding site [chemical binding]; other site 758678006169 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 758678006170 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 758678006171 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758678006172 active site 758678006173 catalytic residues [active] 758678006174 metal binding site [ion binding]; metal-binding site 758678006175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006176 non-specific DNA binding site [nucleotide binding]; other site 758678006177 salt bridge; other site 758678006178 sequence-specific DNA binding site [nucleotide binding]; other site 758678006179 transglutaminase; Provisional; Region: tgl; PRK03187 758678006180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678006181 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 758678006182 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 758678006183 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 758678006184 tetrameric interface [polypeptide binding]; other site 758678006185 activator binding site; other site 758678006186 NADP binding site [chemical binding]; other site 758678006187 substrate binding site [chemical binding]; other site 758678006188 catalytic residues [active] 758678006189 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 758678006190 FAD binding pocket [chemical binding]; other site 758678006191 FAD binding motif [chemical binding]; other site 758678006192 phosphate binding motif [ion binding]; other site 758678006193 beta-alpha-beta structure motif; other site 758678006194 NAD binding pocket [chemical binding]; other site 758678006195 Heme binding pocket [chemical binding]; other site 758678006196 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 758678006197 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 758678006198 active site 758678006199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678006200 Walker A/P-loop; other site 758678006201 ATP binding site [chemical binding]; other site 758678006202 Q-loop/lid; other site 758678006203 ABC transporter signature motif; other site 758678006204 Walker B; other site 758678006205 D-loop; other site 758678006206 H-loop/switch region; other site 758678006207 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 758678006208 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678006209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678006210 Spore germination protein; Region: Spore_permease; pfam03845 758678006211 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 758678006212 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 758678006213 active site 758678006214 NTP binding site [chemical binding]; other site 758678006215 metal binding triad [ion binding]; metal-binding site 758678006216 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 758678006217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678006218 Zn2+ binding site [ion binding]; other site 758678006219 Mg2+ binding site [ion binding]; other site 758678006220 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 758678006221 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 758678006222 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 758678006223 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 758678006224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678006225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758678006226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678006227 dimer interface [polypeptide binding]; other site 758678006228 phosphorylation site [posttranslational modification] 758678006229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678006230 ATP binding site [chemical binding]; other site 758678006231 Mg2+ binding site [ion binding]; other site 758678006232 G-X-G motif; other site 758678006233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678006235 active site 758678006236 phosphorylation site [posttranslational modification] 758678006237 intermolecular recognition site; other site 758678006238 dimerization interface [polypeptide binding]; other site 758678006239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678006240 DNA binding site [nucleotide binding] 758678006241 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 758678006242 Transcription factor homologous to NACalpha-BTF3 [Transcription]; Region: EGD2; COG1308 758678006243 hypothetical protein; Provisional; Region: PRK06921 758678006244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678006245 Walker A motif; other site 758678006246 ATP binding site [chemical binding]; other site 758678006247 Walker B motif; other site 758678006248 arginine finger; other site 758678006249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678006250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006251 non-specific DNA binding site [nucleotide binding]; other site 758678006252 salt bridge; other site 758678006253 sequence-specific DNA binding site [nucleotide binding]; other site 758678006254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 758678006255 non-specific DNA binding site [nucleotide binding]; other site 758678006256 salt bridge; other site 758678006257 sequence-specific DNA binding site [nucleotide binding]; other site 758678006258 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 758678006259 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 758678006260 NlpC/P60 family; Region: NLPC_P60; pfam00877 758678006261 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678006262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678006263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006264 non-specific DNA binding site [nucleotide binding]; other site 758678006265 salt bridge; other site 758678006266 sequence-specific DNA binding site [nucleotide binding]; other site 758678006267 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 758678006268 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 758678006269 catalytic residues [active] 758678006270 catalytic nucleophile [active] 758678006271 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678006272 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678006273 active site 758678006274 metal binding site [ion binding]; metal-binding site 758678006275 Bacterial SH3 domain; Region: SH3_3; pfam08239 758678006276 Haemolysin XhlA; Region: XhlA; pfam10779 758678006277 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 758678006278 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 758678006279 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 758678006280 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 758678006281 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758678006282 Short C-terminal domain; Region: SHOCT; pfam09851 758678006283 Phage XkdN-like protein; Region: XkdN; pfam08890 758678006284 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 758678006285 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 758678006286 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 758678006287 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 758678006288 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 758678006289 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 758678006290 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 758678006291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 758678006292 Terminase-like family; Region: Terminase_6; pfam03237 758678006293 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 758678006294 Terminase small subunit; Region: Terminase_2; pfam03592 758678006295 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 758678006296 homodimer interface [polypeptide binding]; other site 758678006297 metal binding site [ion binding]; metal-binding site 758678006298 DEAD-like helicases superfamily; Region: DEXDc; smart00487 758678006299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678006300 ATP binding site [chemical binding]; other site 758678006301 putative Mg++ binding site [ion binding]; other site 758678006302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678006303 nucleotide binding region [chemical binding]; other site 758678006304 ATP-binding site [chemical binding]; other site 758678006305 VRR-NUC domain; Region: VRR_NUC; pfam08774 758678006306 Virulence-associated protein E; Region: VirE; pfam05272 758678006307 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 758678006308 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678006309 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 758678006310 cofactor binding site; other site 758678006311 DNA binding site [nucleotide binding] 758678006312 substrate interaction site [chemical binding]; other site 758678006313 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678006314 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 758678006315 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 758678006316 replication factor C large subunit; Provisional; Region: PRK04195 758678006317 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 758678006318 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 758678006319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678006320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678006321 DNA binding residues [nucleotide binding] 758678006322 ORF6N domain; Region: ORF6N; pfam10543 758678006323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006324 non-specific DNA binding site [nucleotide binding]; other site 758678006325 salt bridge; other site 758678006326 sequence-specific DNA binding site [nucleotide binding]; other site 758678006327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678006328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006329 non-specific DNA binding site [nucleotide binding]; other site 758678006330 salt bridge; other site 758678006331 sequence-specific DNA binding site [nucleotide binding]; other site 758678006332 Glucose inhibited division protein A; Region: GIDA; pfam01134 758678006333 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 758678006334 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 758678006335 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 758678006336 tetramer interface [polypeptide binding]; other site 758678006337 active site 758678006338 Uncharacterized conserved protein [Function unknown]; Region: COG2155 758678006339 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 758678006340 dimerization domain swap beta strand [polypeptide binding]; other site 758678006341 regulatory protein interface [polypeptide binding]; other site 758678006342 active site 758678006343 regulatory phosphorylation site [posttranslational modification]; other site 758678006344 aspartate aminotransferase; Provisional; Region: PRK05764 758678006345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678006346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678006347 homodimer interface [polypeptide binding]; other site 758678006348 catalytic residue [active] 758678006349 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 758678006350 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 758678006351 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 758678006352 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 758678006353 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 758678006354 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678006355 Zn2+ binding site [ion binding]; other site 758678006356 Mg2+ binding site [ion binding]; other site 758678006357 recombinase A; Provisional; Region: recA; PRK09354 758678006358 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 758678006359 hexamer interface [polypeptide binding]; other site 758678006360 Walker A motif; other site 758678006361 ATP binding site [chemical binding]; other site 758678006362 Walker B motif; other site 758678006363 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 758678006364 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 758678006365 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 758678006366 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 758678006367 Tetraspanin family; Region: Tetraspannin; pfam00335 758678006368 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 758678006369 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 758678006370 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 758678006371 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 758678006372 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 758678006373 active site 758678006374 aspartate kinase I; Reviewed; Region: PRK08210 758678006375 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 758678006376 nucleotide binding site [chemical binding]; other site 758678006377 substrate binding site [chemical binding]; other site 758678006378 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 758678006379 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 758678006380 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 758678006381 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 758678006382 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 758678006383 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 758678006384 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 758678006385 16S/18S rRNA binding site [nucleotide binding]; other site 758678006386 S13e-L30e interaction site [polypeptide binding]; other site 758678006387 25S rRNA binding site [nucleotide binding]; other site 758678006388 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 758678006389 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 758678006390 active site 758678006391 Riboflavin kinase; Region: Flavokinase; pfam01687 758678006392 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 758678006393 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 758678006394 RNA binding site [nucleotide binding]; other site 758678006395 active site 758678006396 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 758678006397 DHH family; Region: DHH; pfam01368 758678006398 DHHA1 domain; Region: DHHA1; pfam02272 758678006399 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 758678006400 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 758678006401 translation initiation factor IF-2; Region: IF-2; TIGR00487 758678006402 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 758678006403 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 758678006404 G1 box; other site 758678006405 putative GEF interaction site [polypeptide binding]; other site 758678006406 GTP/Mg2+ binding site [chemical binding]; other site 758678006407 Switch I region; other site 758678006408 G2 box; other site 758678006409 G3 box; other site 758678006410 Switch II region; other site 758678006411 G4 box; other site 758678006412 G5 box; other site 758678006413 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 758678006414 Translation-initiation factor 2; Region: IF-2; pfam11987 758678006415 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 758678006416 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 758678006417 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 758678006418 NusA N-terminal domain; Region: NusA_N; pfam08529 758678006419 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 758678006420 RNA binding site [nucleotide binding]; other site 758678006421 homodimer interface [polypeptide binding]; other site 758678006422 NusA-like KH domain; Region: KH_5; pfam13184 758678006423 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 758678006424 G-X-X-G motif; other site 758678006425 Sm and related proteins; Region: Sm_like; cl00259 758678006426 ribosome maturation protein RimP; Reviewed; Region: PRK00092 758678006427 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 758678006428 putative oligomer interface [polypeptide binding]; other site 758678006429 putative RNA binding site [nucleotide binding]; other site 758678006430 DNA polymerase III PolC; Validated; Region: polC; PRK00448 758678006431 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 758678006432 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 758678006433 generic binding surface II; other site 758678006434 generic binding surface I; other site 758678006435 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 758678006436 active site 758678006437 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 758678006438 active site 758678006439 catalytic site [active] 758678006440 substrate binding site [chemical binding]; other site 758678006441 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 758678006442 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 758678006443 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 758678006444 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 758678006445 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 758678006446 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 758678006447 active site 758678006448 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 758678006449 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 758678006450 putative substrate binding region [chemical binding]; other site 758678006451 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 758678006452 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 758678006453 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 758678006454 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 758678006455 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 758678006456 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 758678006457 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 758678006458 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 758678006459 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 758678006460 catalytic residue [active] 758678006461 putative FPP diphosphate binding site; other site 758678006462 putative FPP binding hydrophobic cleft; other site 758678006463 dimer interface [polypeptide binding]; other site 758678006464 putative IPP diphosphate binding site; other site 758678006465 ribosome recycling factor; Reviewed; Region: frr; PRK00083 758678006466 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 758678006467 hinge region; other site 758678006468 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 758678006469 putative nucleotide binding site [chemical binding]; other site 758678006470 uridine monophosphate binding site [chemical binding]; other site 758678006471 homohexameric interface [polypeptide binding]; other site 758678006472 elongation factor Ts; Provisional; Region: tsf; PRK09377 758678006473 UBA/TS-N domain; Region: UBA; pfam00627 758678006474 Elongation factor TS; Region: EF_TS; pfam00889 758678006475 Elongation factor TS; Region: EF_TS; pfam00889 758678006476 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 758678006477 rRNA interaction site [nucleotide binding]; other site 758678006478 S8 interaction site; other site 758678006479 putative laminin-1 binding site; other site 758678006480 transcriptional repressor CodY; Validated; Region: PRK04158 758678006481 CodY GAF-like domain; Region: CodY; pfam06018 758678006482 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 758678006483 DNA topoisomerase I; Validated; Region: PRK05582 758678006484 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 758678006485 active site 758678006486 interdomain interaction site; other site 758678006487 putative metal-binding site [ion binding]; other site 758678006488 nucleotide binding site [chemical binding]; other site 758678006489 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 758678006490 domain I; other site 758678006491 DNA binding groove [nucleotide binding] 758678006492 phosphate binding site [ion binding]; other site 758678006493 domain II; other site 758678006494 domain III; other site 758678006495 nucleotide binding site [chemical binding]; other site 758678006496 catalytic site [active] 758678006497 domain IV; other site 758678006498 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 758678006499 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 758678006500 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 758678006501 DNA protecting protein DprA; Region: dprA; TIGR00732 758678006502 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 758678006503 hypothetical protein; Reviewed; Region: PRK12497 758678006504 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 758678006505 RNA/DNA hybrid binding site [nucleotide binding]; other site 758678006506 active site 758678006507 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 758678006508 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 758678006509 GTP/Mg2+ binding site [chemical binding]; other site 758678006510 G4 box; other site 758678006511 G5 box; other site 758678006512 G1 box; other site 758678006513 Switch I region; other site 758678006514 G2 box; other site 758678006515 G3 box; other site 758678006516 Switch II region; other site 758678006517 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 758678006518 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 758678006519 Catalytic site [active] 758678006520 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 758678006521 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 758678006522 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 758678006523 RimM N-terminal domain; Region: RimM; pfam01782 758678006524 PRC-barrel domain; Region: PRC; pfam05239 758678006525 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 758678006526 hypothetical protein; Provisional; Region: PRK00468 758678006527 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 758678006528 signal recognition particle protein; Provisional; Region: PRK10867 758678006529 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 758678006530 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 758678006531 P loop; other site 758678006532 GTP binding site [chemical binding]; other site 758678006533 Signal peptide binding domain; Region: SRP_SPB; pfam02978 758678006534 putative DNA-binding protein; Validated; Region: PRK00118 758678006535 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 758678006536 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 758678006537 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 758678006538 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678006539 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 758678006540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678006541 FeS/SAM binding site; other site 758678006542 ribonuclease III; Reviewed; Region: rnc; PRK00102 758678006543 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 758678006544 dimerization interface [polypeptide binding]; other site 758678006545 active site 758678006546 metal binding site [ion binding]; metal-binding site 758678006547 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 758678006548 dsRNA binding site [nucleotide binding]; other site 758678006549 acyl carrier protein; Provisional; Region: acpP; PRK00982 758678006550 putative phosphate acyltransferase; Provisional; Region: PRK05331 758678006551 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 758678006552 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 758678006553 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 758678006554 propionate/acetate kinase; Provisional; Region: PRK12379 758678006555 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 758678006556 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758678006557 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678006558 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 758678006559 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 758678006560 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758678006561 Cache domain; Region: Cache_1; pfam02743 758678006562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678006563 dimerization interface [polypeptide binding]; other site 758678006564 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678006565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678006566 dimer interface [polypeptide binding]; other site 758678006567 putative CheW interface [polypeptide binding]; other site 758678006568 Transcriptional regulator; Region: Rrf2; cl17282 758678006569 Uncharacterized conserved protein [Function unknown]; Region: COG1915 758678006570 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 758678006571 Uncharacterized conserved protein [Function unknown]; Region: COG1915 758678006572 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 758678006573 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758678006574 proline racemase; Provisional; Region: PRK13969 758678006575 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758678006576 potential frameshift: common BLAST hit: gi|170756212|ref|YP_001782018.1| PrdE protein 758678006577 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678006578 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678006579 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678006580 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 758678006581 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 758678006582 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 758678006583 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 758678006584 SLBB domain; Region: SLBB; pfam10531 758678006585 Predicted permease; Region: DUF318; cl17795 758678006586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758678006587 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 758678006588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678006589 putative active site [active] 758678006590 heme pocket [chemical binding]; other site 758678006591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678006592 Walker A motif; other site 758678006593 ATP binding site [chemical binding]; other site 758678006594 Walker B motif; other site 758678006595 arginine finger; other site 758678006596 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758678006597 hypothetical protein; Provisional; Region: PRK13670 758678006598 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 758678006599 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 758678006600 Nucleoside recognition; Region: Gate; pfam07670 758678006601 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 758678006602 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 758678006603 active site 758678006604 (T/H)XGH motif; other site 758678006605 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 758678006606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678006607 S-adenosylmethionine binding site [chemical binding]; other site 758678006608 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 758678006609 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 758678006610 ssDNA binding site; other site 758678006611 generic binding surface II; other site 758678006612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678006613 ATP binding site [chemical binding]; other site 758678006614 putative Mg++ binding site [ion binding]; other site 758678006615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678006616 nucleotide binding region [chemical binding]; other site 758678006617 ATP-binding site [chemical binding]; other site 758678006618 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 758678006619 DAK2 domain; Region: Dak2; pfam02734 758678006620 Asp23 family; Region: Asp23; pfam03780 758678006621 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 758678006622 Thiamine pyrophosphokinase; Region: TPK; cd07995 758678006623 active site 758678006624 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 758678006625 dimerization interface [polypeptide binding]; other site 758678006626 thiamine binding site [chemical binding]; other site 758678006627 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 758678006628 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 758678006629 substrate binding site [chemical binding]; other site 758678006630 hexamer interface [polypeptide binding]; other site 758678006631 metal binding site [ion binding]; metal-binding site 758678006632 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 758678006633 GTPase RsgA; Reviewed; Region: PRK00098 758678006634 RNA binding site [nucleotide binding]; other site 758678006635 homodimer interface [polypeptide binding]; other site 758678006636 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 758678006637 GTPase/Zn-binding domain interface [polypeptide binding]; other site 758678006638 GTP/Mg2+ binding site [chemical binding]; other site 758678006639 G4 box; other site 758678006640 G5 box; other site 758678006641 G1 box; other site 758678006642 Switch I region; other site 758678006643 G2 box; other site 758678006644 G3 box; other site 758678006645 Switch II region; other site 758678006646 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 758678006647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 758678006648 active site 758678006649 ATP binding site [chemical binding]; other site 758678006650 substrate binding site [chemical binding]; other site 758678006651 activation loop (A-loop); other site 758678006652 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 758678006653 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 758678006654 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 758678006655 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 758678006656 active site 758678006657 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 758678006658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678006659 FeS/SAM binding site; other site 758678006660 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 758678006661 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 758678006662 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 758678006663 putative active site [active] 758678006664 substrate binding site [chemical binding]; other site 758678006665 putative cosubstrate binding site; other site 758678006666 catalytic site [active] 758678006667 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 758678006668 substrate binding site [chemical binding]; other site 758678006669 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758678006670 active site 758678006671 catalytic residues [active] 758678006672 metal binding site [ion binding]; metal-binding site 758678006673 primosome assembly protein PriA; Validated; Region: PRK05580 758678006674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678006675 ATP binding site [chemical binding]; other site 758678006676 putative Mg++ binding site [ion binding]; other site 758678006677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678006678 nucleotide binding region [chemical binding]; other site 758678006679 ATP-binding site [chemical binding]; other site 758678006680 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 758678006681 Flavoprotein; Region: Flavoprotein; pfam02441 758678006682 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 758678006683 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 758678006684 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 758678006685 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 758678006686 catalytic site [active] 758678006687 G-X2-G-X-G-K; other site 758678006688 hypothetical protein; Provisional; Region: PRK04323 758678006689 hypothetical protein; Provisional; Region: PRK11820 758678006690 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 758678006691 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 758678006692 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 758678006693 active site 758678006694 homotetramer interface [polypeptide binding]; other site 758678006695 homodimer interface [polypeptide binding]; other site 758678006696 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 758678006697 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 758678006698 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 758678006699 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 758678006700 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 758678006701 GTP-binding protein Der; Reviewed; Region: PRK00093 758678006702 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 758678006703 G1 box; other site 758678006704 GTP/Mg2+ binding site [chemical binding]; other site 758678006705 Switch I region; other site 758678006706 G2 box; other site 758678006707 Switch II region; other site 758678006708 G3 box; other site 758678006709 G4 box; other site 758678006710 G5 box; other site 758678006711 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 758678006712 G1 box; other site 758678006713 GTP/Mg2+ binding site [chemical binding]; other site 758678006714 Switch I region; other site 758678006715 G2 box; other site 758678006716 G3 box; other site 758678006717 Switch II region; other site 758678006718 G4 box; other site 758678006719 G5 box; other site 758678006720 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 758678006721 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 758678006722 Protein of unknown function (DUF512); Region: DUF512; pfam04459 758678006723 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 758678006724 PhoU domain; Region: PhoU; pfam01895 758678006725 PhoU domain; Region: PhoU; pfam01895 758678006726 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 758678006727 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 758678006728 Walker A/P-loop; other site 758678006729 ATP binding site [chemical binding]; other site 758678006730 Q-loop/lid; other site 758678006731 ABC transporter signature motif; other site 758678006732 Walker B; other site 758678006733 D-loop; other site 758678006734 H-loop/switch region; other site 758678006735 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 758678006736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678006737 dimer interface [polypeptide binding]; other site 758678006738 conserved gate region; other site 758678006739 putative PBP binding loops; other site 758678006740 ABC-ATPase subunit interface; other site 758678006741 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 758678006742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678006743 dimer interface [polypeptide binding]; other site 758678006744 conserved gate region; other site 758678006745 putative PBP binding loops; other site 758678006746 ABC-ATPase subunit interface; other site 758678006747 potential frameshift: common BLAST hit: gi|153940939|ref|YP_001391823.1| phosphate ABC transporter, phosphate-binding protein 758678006748 PBP superfamily domain; Region: PBP_like_2; cl17296 758678006749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678006750 dimerization interface [polypeptide binding]; other site 758678006751 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758678006752 PAS domain; Region: PAS; smart00091 758678006753 putative active site [active] 758678006754 heme pocket [chemical binding]; other site 758678006755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678006756 dimer interface [polypeptide binding]; other site 758678006757 phosphorylation site [posttranslational modification] 758678006758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678006759 ATP binding site [chemical binding]; other site 758678006760 Mg2+ binding site [ion binding]; other site 758678006761 G-X-G motif; other site 758678006762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678006763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678006764 active site 758678006765 phosphorylation site [posttranslational modification] 758678006766 intermolecular recognition site; other site 758678006767 dimerization interface [polypeptide binding]; other site 758678006768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678006769 DNA binding site [nucleotide binding] 758678006770 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 758678006771 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 758678006772 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 758678006773 ATP cone domain; Region: ATP-cone; pfam03477 758678006774 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 758678006775 sporulation sigma factor SigG; Reviewed; Region: PRK08215 758678006776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678006777 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758678006778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678006779 DNA binding residues [nucleotide binding] 758678006780 sporulation sigma factor SigE; Reviewed; Region: PRK08301 758678006781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678006782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678006783 DNA binding residues [nucleotide binding] 758678006784 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 758678006785 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 758678006786 cell division protein FtsZ; Validated; Region: PRK09330 758678006787 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 758678006788 nucleotide binding site [chemical binding]; other site 758678006789 SulA interaction site; other site 758678006790 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 758678006791 Cell division protein FtsA; Region: FtsA; smart00842 758678006792 Cell division protein FtsA; Region: FtsA; pfam14450 758678006793 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758678006794 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 758678006795 DXD motif; other site 758678006796 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 758678006797 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 758678006798 Walker A motif; other site 758678006799 ATP binding site [chemical binding]; other site 758678006800 Walker B motif; other site 758678006801 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 758678006802 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758678006803 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758678006804 shikimate binding site; other site 758678006805 NAD(P) binding site [chemical binding]; other site 758678006806 sporulation sigma factor SigK; Reviewed; Region: PRK05803 758678006807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678006808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678006809 DNA binding residues [nucleotide binding] 758678006810 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 758678006811 conserved domain; Region: TIGR02271 758678006812 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 758678006813 RecT family; Region: RecT; pfam03837 758678006814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678006815 non-specific DNA binding site [nucleotide binding]; other site 758678006816 salt bridge; other site 758678006817 sequence-specific DNA binding site [nucleotide binding]; other site 758678006818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758678006819 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 758678006820 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758678006821 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 758678006822 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 758678006823 Sugar specificity; other site 758678006824 Pyrimidine base specificity; other site 758678006825 ATP-binding site [chemical binding]; other site 758678006826 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 758678006827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678006828 S-adenosylmethionine binding site [chemical binding]; other site 758678006829 YceG-like family; Region: YceG; pfam02618 758678006830 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 758678006831 dimerization interface [polypeptide binding]; other site 758678006832 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 758678006833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678006834 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 758678006835 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758678006836 metal binding site 2 [ion binding]; metal-binding site 758678006837 putative DNA binding helix; other site 758678006838 metal binding site 1 [ion binding]; metal-binding site 758678006839 dimer interface [polypeptide binding]; other site 758678006840 structural Zn2+ binding site [ion binding]; other site 758678006841 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 758678006842 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 758678006843 hypothetical protein; Provisional; Region: PRK05473 758678006844 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758678006845 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758678006846 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 758678006847 PRC-barrel domain; Region: PRC; pfam05239 758678006848 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 758678006849 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 758678006850 trimerization site [polypeptide binding]; other site 758678006851 active site 758678006852 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 758678006853 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 758678006854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678006855 catalytic residue [active] 758678006856 Transcriptional regulator; Region: Rrf2; cl17282 758678006857 Rrf2 family protein; Region: rrf2_super; TIGR00738 758678006858 recombination factor protein RarA; Reviewed; Region: PRK13342 758678006859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678006860 Walker A motif; other site 758678006861 ATP binding site [chemical binding]; other site 758678006862 Walker B motif; other site 758678006863 arginine finger; other site 758678006864 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 758678006865 histidinol-phosphatase; Provisional; Region: PRK05588 758678006866 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 758678006867 active site 758678006868 Predicted permeases [General function prediction only]; Region: COG0679 758678006869 EDD domain protein, DegV family; Region: DegV; TIGR00762 758678006870 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 758678006871 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 758678006872 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 758678006873 CPxP motif; other site 758678006874 DsrE/DsrF-like family; Region: DrsE; pfam02635 758678006875 ornithine cyclodeaminase; Validated; Region: PRK08618 758678006876 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 758678006877 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678006878 amino acid carrier protein; Region: agcS; TIGR00835 758678006879 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678006880 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758678006881 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 758678006882 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 758678006883 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 758678006884 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 758678006885 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 758678006886 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 758678006887 dimerization interface [polypeptide binding]; other site 758678006888 ATP binding site [chemical binding]; other site 758678006889 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 758678006890 dimerization interface [polypeptide binding]; other site 758678006891 ATP binding site [chemical binding]; other site 758678006892 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 758678006893 putative active site [active] 758678006894 catalytic triad [active] 758678006895 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678006896 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678006897 phosphoenolpyruvate synthase; Validated; Region: PRK06241 758678006898 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 758678006899 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758678006900 Phosphopantetheine attachment site; Region: PP-binding; cl09936 758678006901 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 758678006902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758678006903 active site 758678006904 AMP binding site [chemical binding]; other site 758678006905 acyl-activating enzyme (AAE) consensus motif; other site 758678006906 CoA binding site [chemical binding]; other site 758678006907 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 758678006908 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 758678006909 dimer interface [polypeptide binding]; other site 758678006910 active site 758678006911 CoA binding pocket [chemical binding]; other site 758678006912 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758678006913 AMP-binding enzyme; Region: AMP-binding; pfam00501 758678006914 acyl-activating enzyme (AAE) consensus motif; other site 758678006915 AMP binding site [chemical binding]; other site 758678006916 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758678006917 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678006918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678006919 Coenzyme A binding pocket [chemical binding]; other site 758678006920 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 758678006921 Ligand Binding Site [chemical binding]; other site 758678006922 hypothetical protein; Validated; Region: PRK07080 758678006923 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 758678006924 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 758678006925 ornithine carbamoyltransferase; Provisional; Region: PRK04284 758678006926 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758678006927 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758678006928 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 758678006929 carbamate kinase; Reviewed; Region: PRK12686 758678006930 putative substrate binding site [chemical binding]; other site 758678006931 nucleotide binding site [chemical binding]; other site 758678006932 nucleotide binding site [chemical binding]; other site 758678006933 homodimer interface [polypeptide binding]; other site 758678006934 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 758678006935 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 758678006936 dimer interface [polypeptide binding]; other site 758678006937 active site 758678006938 glycine-pyridoxal phosphate binding site [chemical binding]; other site 758678006939 folate binding site [chemical binding]; other site 758678006940 Uncharacterized conserved protein [Function unknown]; Region: COG2966 758678006941 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 758678006942 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 758678006943 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 758678006944 putative homodimer interface [polypeptide binding]; other site 758678006945 putative homotetramer interface [polypeptide binding]; other site 758678006946 putative allosteric switch controlling residues; other site 758678006947 putative metal binding site [ion binding]; other site 758678006948 putative homodimer-homodimer interface [polypeptide binding]; other site 758678006949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678006950 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 758678006951 active site 758678006952 motif I; other site 758678006953 motif II; other site 758678006954 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758678006955 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 758678006956 NAD(P) binding site [chemical binding]; other site 758678006957 LDH/MDH dimer interface [polypeptide binding]; other site 758678006958 substrate binding site [chemical binding]; other site 758678006959 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678006960 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678006961 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 758678006962 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 758678006963 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 758678006964 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 758678006965 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 758678006966 oligomer interface [polypeptide binding]; other site 758678006967 putative active site [active] 758678006968 metal binding site [ion binding]; metal-binding site 758678006969 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 758678006970 oligomer interface [polypeptide binding]; other site 758678006971 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 758678006972 metal binding site [ion binding]; metal-binding site 758678006973 putative Cl binding site [ion binding]; other site 758678006974 aspartate ring; other site 758678006975 basic sphincter; other site 758678006976 hydrophobic gate; other site 758678006977 periplasmic entrance; other site 758678006978 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 758678006979 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 758678006980 HPr kinase/phosphorylase; Provisional; Region: PRK05428 758678006981 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 758678006982 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 758678006983 Hpr binding site; other site 758678006984 active site 758678006985 homohexamer subunit interaction site [polypeptide binding]; other site 758678006986 Uncharacterized conserved protein [Function unknown]; Region: COG0398 758678006987 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758678006988 Uncharacterized conserved protein [Function unknown]; Region: COG0398 758678006989 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758678006990 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 758678006991 Cysteine-rich domain; Region: CCG; pfam02754 758678006992 Cysteine-rich domain; Region: CCG; pfam02754 758678006993 Phosphotransferase enzyme family; Region: APH; pfam01636 758678006994 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 758678006995 active site 758678006996 ATP binding site [chemical binding]; other site 758678006997 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 758678006998 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 758678006999 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 758678007000 Probable Catalytic site; other site 758678007001 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 758678007002 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758678007003 active site residue [active] 758678007004 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 758678007005 active site residue [active] 758678007006 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 758678007007 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 758678007008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678007009 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678007010 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 758678007011 active site 758678007012 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758678007013 active site 758678007014 catalytic residues [active] 758678007015 metal binding site [ion binding]; metal-binding site 758678007016 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 758678007017 V-type ATP synthase subunit B; Provisional; Region: PRK04196 758678007018 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758678007019 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 758678007020 Walker A motif homologous position; other site 758678007021 Walker B motif; other site 758678007022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758678007023 V-type ATP synthase subunit A; Provisional; Region: PRK04192 758678007024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758678007025 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 758678007026 Walker A motif/ATP binding site; other site 758678007027 Walker B motif; other site 758678007028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758678007029 V-type ATP synthase subunit F; Provisional; Region: PRK01395 758678007030 V-type ATP synthase subunit C; Provisional; Region: PRK01198 758678007031 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 758678007032 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 758678007033 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 758678007034 V-type ATP synthase subunit K; Validated; Region: PRK06558 758678007035 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 758678007036 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 758678007037 V-type ATP synthase subunit I; Validated; Region: PRK05771 758678007038 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758678007039 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 758678007040 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 758678007041 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 758678007042 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 758678007043 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 758678007044 Zn binding site [ion binding]; other site 758678007045 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 758678007046 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 758678007047 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 758678007048 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678007049 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 758678007050 Soluble P-type ATPase [General function prediction only]; Region: COG4087 758678007051 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 758678007052 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 758678007053 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758678007054 DRTGG domain; Region: DRTGG; pfam07085 758678007055 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758678007056 DHH family; Region: DHH; pfam01368 758678007057 DHHA2 domain; Region: DHHA2; pfam02833 758678007058 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 758678007059 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758678007060 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758678007061 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 758678007062 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758678007063 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758678007064 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 758678007065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678007066 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758678007067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678007068 DNA binding residues [nucleotide binding] 758678007069 Flagellar protein YcgR; Region: YcgR_2; pfam12945 758678007070 PilZ domain; Region: PilZ; pfam07238 758678007071 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 758678007072 FHIPEP family; Region: FHIPEP; pfam00771 758678007073 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 758678007074 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 758678007075 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 758678007076 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 758678007077 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 758678007078 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 758678007079 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 758678007080 flagellar motor protein MotS; Reviewed; Region: PRK06925 758678007081 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 758678007082 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758678007083 ligand binding site [chemical binding]; other site 758678007084 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 758678007085 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 758678007086 Flagellar protein (FlbD); Region: FlbD; pfam06289 758678007087 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 758678007088 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758678007089 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758678007090 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 758678007091 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 758678007092 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 758678007093 Flagellar FliJ protein; Region: FliJ; pfam02050 758678007094 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 758678007095 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758678007096 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 758678007097 Walker A motif/ATP binding site; other site 758678007098 Walker B motif; other site 758678007099 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 758678007100 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 758678007101 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 758678007102 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 758678007103 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758678007104 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758678007105 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 758678007106 argininosuccinate lyase; Provisional; Region: PRK00855 758678007107 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 758678007108 active sites [active] 758678007109 tetramer interface [polypeptide binding]; other site 758678007110 argininosuccinate synthase; Provisional; Region: PRK13820 758678007111 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 758678007112 ANP binding site [chemical binding]; other site 758678007113 Substrate Binding Site II [chemical binding]; other site 758678007114 Substrate Binding Site I [chemical binding]; other site 758678007115 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 758678007116 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 758678007117 putative active site [active] 758678007118 catalytic site [active] 758678007119 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 758678007120 putative active site [active] 758678007121 catalytic site [active] 758678007122 Predicted membrane protein [Function unknown]; Region: COG4129 758678007123 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 758678007124 Predicted integral membrane protein [Function unknown]; Region: COG5652 758678007125 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 758678007126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758678007127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758678007128 NAD(P) binding site [chemical binding]; other site 758678007129 active site 758678007130 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 758678007131 NeuB family; Region: NeuB; pfam03102 758678007132 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 758678007133 NeuB binding interface [polypeptide binding]; other site 758678007134 putative substrate binding site [chemical binding]; other site 758678007135 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 758678007136 ligand binding site; other site 758678007137 tetramer interface; other site 758678007138 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 758678007139 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 758678007140 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 758678007141 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 758678007142 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 758678007143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678007144 UDP-galactopyranose mutase; Region: GLF; pfam03275 758678007145 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 758678007146 Bacterial sugar transferase; Region: Bac_transf; pfam02397 758678007147 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 758678007148 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758678007149 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 758678007150 Chain length determinant protein; Region: Wzz; cl15801 758678007151 Transcriptional regulator [Transcription]; Region: LytR; COG1316 758678007152 Putative motility protein; Region: YjfB_motility; pfam14070 758678007153 flagellin; Provisional; Region: PRK12804 758678007154 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758678007155 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 758678007156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758678007157 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 758678007158 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 758678007159 inhibitor-cofactor binding pocket; inhibition site 758678007160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678007161 catalytic residue [active] 758678007162 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 758678007163 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 758678007164 NAD binding site [chemical binding]; other site 758678007165 substrate binding site [chemical binding]; other site 758678007166 active site 758678007167 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 758678007168 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 758678007169 putative trimer interface [polypeptide binding]; other site 758678007170 putative CoA binding site [chemical binding]; other site 758678007171 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 758678007172 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 758678007173 ligand binding site; other site 758678007174 tetramer interface; other site 758678007175 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758678007176 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 758678007177 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 758678007178 NeuB family; Region: NeuB; pfam03102 758678007179 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 758678007180 NeuB binding interface [polypeptide binding]; other site 758678007181 putative substrate binding site [chemical binding]; other site 758678007182 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758678007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678007184 S-adenosylmethionine binding site [chemical binding]; other site 758678007185 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 758678007186 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 758678007187 active site 758678007188 homodimer interface [polypeptide binding]; other site 758678007189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 758678007190 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 758678007191 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 758678007192 Substrate binding site; other site 758678007193 metal-binding site 758678007194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 758678007195 flagellin; Provisional; Region: PRK12804 758678007196 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758678007197 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 758678007198 Flagellar protein FliT; Region: FliT; pfam05400 758678007199 flagellar capping protein; Validated; Region: fliD; PRK07737 758678007200 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 758678007201 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 758678007202 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 758678007203 FlaG protein; Region: FlaG; pfam03646 758678007204 carbon storage regulator; Provisional; Region: PRK01712 758678007205 flagellar assembly protein FliW; Provisional; Region: PRK13285 758678007206 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 758678007207 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758678007208 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 758678007209 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 758678007210 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758678007211 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758678007212 FlgN protein; Region: FlgN; pfam05130 758678007213 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 758678007214 flagellar motor switch protein; Validated; Region: PRK08119 758678007215 CheC-like family; Region: CheC; pfam04509 758678007216 CheC-like family; Region: CheC; pfam04509 758678007217 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 758678007218 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 758678007219 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 758678007220 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 758678007221 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758678007222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678007223 active site 758678007224 phosphorylation site [posttranslational modification] 758678007225 intermolecular recognition site; other site 758678007226 dimerization interface [polypeptide binding]; other site 758678007227 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 758678007228 CheC-like family; Region: CheC; pfam04509 758678007229 CheC-like family; Region: CheC; pfam04509 758678007230 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 758678007231 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 758678007232 putative binding surface; other site 758678007233 active site 758678007234 P2 response regulator binding domain; Region: P2; pfam07194 758678007235 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 758678007236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678007237 ATP binding site [chemical binding]; other site 758678007238 Mg2+ binding site [ion binding]; other site 758678007239 G-X-G motif; other site 758678007240 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 758678007241 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 758678007242 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 758678007243 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 758678007244 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 758678007245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678007246 active site 758678007247 phosphorylation site [posttranslational modification] 758678007248 intermolecular recognition site; other site 758678007249 dimerization interface [polypeptide binding]; other site 758678007250 CheB methylesterase; Region: CheB_methylest; pfam01339 758678007251 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 758678007252 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 758678007253 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678007254 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 758678007255 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678007256 active site turn [active] 758678007257 phosphorylation site [posttranslational modification] 758678007258 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678007259 HPr interaction site; other site 758678007260 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678007261 active site 758678007262 phosphorylation site [posttranslational modification] 758678007263 transcriptional antiterminator BglG; Provisional; Region: PRK09772 758678007264 CAT RNA binding domain; Region: CAT_RBD; smart01061 758678007265 PRD domain; Region: PRD; pfam00874 758678007266 PRD domain; Region: PRD; pfam00874 758678007267 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 758678007268 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 758678007269 homodimer interface [polypeptide binding]; other site 758678007270 substrate-cofactor binding pocket; other site 758678007271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678007272 catalytic residue [active] 758678007273 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 758678007274 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 758678007275 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758678007276 dimer interface [polypeptide binding]; other site 758678007277 PYR/PP interface [polypeptide binding]; other site 758678007278 TPP binding site [chemical binding]; other site 758678007279 substrate binding site [chemical binding]; other site 758678007280 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 758678007281 Domain of unknown function; Region: EKR; smart00890 758678007282 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678007283 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 758678007284 TPP-binding site [chemical binding]; other site 758678007285 dimer interface [polypeptide binding]; other site 758678007286 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 758678007287 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 758678007288 active site 758678007289 homodimer interface [polypeptide binding]; other site 758678007290 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 758678007291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678007292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678007293 dimer interface [polypeptide binding]; other site 758678007294 phosphorylation site [posttranslational modification] 758678007295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678007296 ATP binding site [chemical binding]; other site 758678007297 Mg2+ binding site [ion binding]; other site 758678007298 G-X-G motif; other site 758678007299 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 758678007300 DHH family; Region: DHH; pfam01368 758678007301 DHHA1 domain; Region: DHHA1; pfam02272 758678007302 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 758678007303 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 758678007304 AP (apurinic/apyrimidinic) site pocket; other site 758678007305 DNA interaction; other site 758678007306 Metal-binding active site; metal-binding site 758678007307 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758678007308 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758678007309 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 758678007310 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 758678007311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 758678007312 Predicted membrane protein [Function unknown]; Region: COG2246 758678007313 GtrA-like protein; Region: GtrA; pfam04138 758678007314 DJ-1 family protein; Region: not_thiJ; TIGR01383 758678007315 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 758678007316 conserved cys residue [active] 758678007317 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 758678007318 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 758678007319 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 758678007320 CAP-like domain; other site 758678007321 active site 758678007322 primary dimer interface [polypeptide binding]; other site 758678007323 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758678007324 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 758678007325 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758678007326 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 758678007327 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 758678007328 NodB motif; other site 758678007329 active site 758678007330 catalytic site [active] 758678007331 Zn binding site [ion binding]; other site 758678007332 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 758678007333 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 758678007334 NAD binding site [chemical binding]; other site 758678007335 homodimer interface [polypeptide binding]; other site 758678007336 active site 758678007337 substrate binding site [chemical binding]; other site 758678007338 flavodoxin; Provisional; Region: PRK05568 758678007339 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 758678007340 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678007341 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678007342 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 758678007343 putative dimer interface [polypeptide binding]; other site 758678007344 catalytic triad [active] 758678007345 glycerol kinase; Provisional; Region: glpK; PRK00047 758678007346 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 758678007347 N- and C-terminal domain interface [polypeptide binding]; other site 758678007348 active site 758678007349 MgATP binding site [chemical binding]; other site 758678007350 catalytic site [active] 758678007351 metal binding site [ion binding]; metal-binding site 758678007352 glycerol binding site [chemical binding]; other site 758678007353 homotetramer interface [polypeptide binding]; other site 758678007354 homodimer interface [polypeptide binding]; other site 758678007355 FBP binding site [chemical binding]; other site 758678007356 protein IIAGlc interface [polypeptide binding]; other site 758678007357 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 758678007358 amphipathic channel; other site 758678007359 Asn-Pro-Ala signature motifs; other site 758678007360 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 758678007361 VanZ like family; Region: VanZ; pfam04892 758678007362 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678007363 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678007364 Walker A/P-loop; other site 758678007365 ATP binding site [chemical binding]; other site 758678007366 Q-loop/lid; other site 758678007367 ABC transporter signature motif; other site 758678007368 Walker B; other site 758678007369 D-loop; other site 758678007370 H-loop/switch region; other site 758678007371 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678007372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678007373 DNA-binding site [nucleotide binding]; DNA binding site 758678007374 VanZ like family; Region: VanZ; cl01971 758678007375 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 758678007376 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 758678007377 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 758678007378 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 758678007379 Spore germination protein; Region: Spore_permease; pfam03845 758678007380 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 758678007381 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758678007382 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 758678007383 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 758678007384 active site 758678007385 multimer interface [polypeptide binding]; other site 758678007386 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 758678007387 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758678007388 ATP binding site [chemical binding]; other site 758678007389 Mg++ binding site [ion binding]; other site 758678007390 motif III; other site 758678007391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678007392 nucleotide binding region [chemical binding]; other site 758678007393 ATP-binding site [chemical binding]; other site 758678007394 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 758678007395 RNA binding site [nucleotide binding]; other site 758678007396 Probable zinc-binding domain; Region: zf-trcl; pfam13451 758678007397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678007398 dimer interface [polypeptide binding]; other site 758678007399 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 758678007400 putative CheW interface [polypeptide binding]; other site 758678007401 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758678007402 Ligand Binding Site [chemical binding]; other site 758678007403 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 758678007404 4Fe-4S binding domain; Region: Fer4_5; pfam12801 758678007405 4Fe-4S binding domain; Region: Fer4; cl02805 758678007406 glutaminase; Provisional; Region: PRK00971 758678007407 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 758678007408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 758678007409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 758678007410 TraX protein; Region: TraX; cl05434 758678007411 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 758678007412 DNA polymerase IV; Provisional; Region: PRK14133 758678007413 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 758678007414 active site 758678007415 DNA binding site [nucleotide binding] 758678007416 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 758678007417 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 758678007418 homodimer interface [polypeptide binding]; other site 758678007419 active site 758678007420 FMN binding site [chemical binding]; other site 758678007421 substrate binding site [chemical binding]; other site 758678007422 4Fe-4S binding domain; Region: Fer4; pfam00037 758678007423 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 758678007424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678007425 active site 758678007426 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 758678007427 Uncharacterized conserved protein [Function unknown]; Region: COG1434 758678007428 putative active site [active] 758678007429 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758678007430 MarR family; Region: MarR_2; pfam12802 758678007431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678007432 Walker A/P-loop; other site 758678007433 ATP binding site [chemical binding]; other site 758678007434 Q-loop/lid; other site 758678007435 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758678007436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678007437 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 758678007438 Walker A/P-loop; other site 758678007439 ATP binding site [chemical binding]; other site 758678007440 Q-loop/lid; other site 758678007441 ABC transporter signature motif; other site 758678007442 Walker B; other site 758678007443 D-loop; other site 758678007444 H-loop/switch region; other site 758678007445 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 758678007446 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 758678007447 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 758678007448 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 758678007449 Carbohydrate binding domain; Region: CBM_25; smart01066 758678007450 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758678007451 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758678007452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678007453 dimerization interface [polypeptide binding]; other site 758678007454 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678007455 dimer interface [polypeptide binding]; other site 758678007456 putative CheW interface [polypeptide binding]; other site 758678007457 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 758678007458 nudix motif; other site 758678007459 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758678007460 metal binding site 2 [ion binding]; metal-binding site 758678007461 putative DNA binding helix; other site 758678007462 metal binding site 1 [ion binding]; metal-binding site 758678007463 dimer interface [polypeptide binding]; other site 758678007464 structural Zn2+ binding site [ion binding]; other site 758678007465 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 758678007466 Glyco_18 domain; Region: Glyco_18; smart00636 758678007467 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 758678007468 active site 758678007469 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 758678007470 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 758678007471 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 758678007472 active site 758678007473 trimer interface [polypeptide binding]; other site 758678007474 allosteric site; other site 758678007475 active site lid [active] 758678007476 hexamer (dimer of trimers) interface [polypeptide binding]; other site 758678007477 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 758678007478 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 758678007479 active site 758678007480 dimer interface [polypeptide binding]; other site 758678007481 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758678007482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678007483 DNA-binding site [nucleotide binding]; DNA binding site 758678007484 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 758678007485 PQQ-like domain; Region: PQQ_2; pfam13360 758678007486 PQQ-like domain; Region: PQQ_2; pfam13360 758678007487 CAT RNA binding domain; Region: CAT_RBD; smart01061 758678007488 transcriptional antiterminator BglG; Provisional; Region: PRK09772 758678007489 PRD domain; Region: PRD; pfam00874 758678007490 PRD domain; Region: PRD; pfam00874 758678007491 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678007492 HPr interaction site; other site 758678007493 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678007494 active site 758678007495 phosphorylation site [posttranslational modification] 758678007496 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678007497 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 758678007498 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678007499 active site turn [active] 758678007500 phosphorylation site [posttranslational modification] 758678007501 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678007502 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678007503 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758678007504 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758678007505 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 758678007506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678007507 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758678007508 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758678007509 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 758678007510 FAD binding site [chemical binding]; other site 758678007511 homotetramer interface [polypeptide binding]; other site 758678007512 substrate binding pocket [chemical binding]; other site 758678007513 catalytic base [active] 758678007514 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758678007515 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758678007516 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 758678007517 Rubredoxin; Region: Rubredoxin; pfam00301 758678007518 iron binding site [ion binding]; other site 758678007519 HTH-like domain; Region: HTH_21; pfam13276 758678007520 Integrase core domain; Region: rve; pfam00665 758678007521 Integrase core domain; Region: rve_2; pfam13333 758678007522 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 758678007523 Coenzyme A transferase; Region: CoA_trans; cl17247 758678007524 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 758678007525 Ligand binding site; other site 758678007526 metal-binding site 758678007527 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758678007528 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758678007529 catalytic loop [active] 758678007530 iron binding site [ion binding]; other site 758678007531 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758678007532 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 758678007533 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758678007534 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758678007535 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758678007536 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758678007537 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 758678007538 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758678007539 active site turn [active] 758678007540 phosphorylation site [posttranslational modification] 758678007541 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758678007542 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758678007543 HPr interaction site; other site 758678007544 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758678007545 active site 758678007546 phosphorylation site [posttranslational modification] 758678007547 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 758678007548 beta-galactosidase; Region: BGL; TIGR03356 758678007549 transcriptional antiterminator BglG; Provisional; Region: PRK09772 758678007550 CAT RNA binding domain; Region: CAT_RBD; smart01061 758678007551 PRD domain; Region: PRD; pfam00874 758678007552 PRD domain; Region: PRD; pfam00874 758678007553 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758678007554 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758678007555 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 758678007556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678007557 motif II; other site 758678007558 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 758678007559 amidase catalytic site [active] 758678007560 Zn binding residues [ion binding]; other site 758678007561 substrate binding site [chemical binding]; other site 758678007562 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 758678007563 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 758678007564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678007565 FeS/SAM binding site; other site 758678007566 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 758678007567 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 758678007568 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 758678007569 TRAM domain; Region: TRAM; pfam01938 758678007570 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 758678007571 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 758678007572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678007573 S-adenosylmethionine binding site [chemical binding]; other site 758678007574 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 758678007575 Sulfatase; Region: Sulfatase; pfam00884 758678007576 hypothetical protein; Provisional; Region: PRK10621 758678007577 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758678007578 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 758678007579 homopentamer interface [polypeptide binding]; other site 758678007580 active site 758678007581 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 758678007582 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 758678007583 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 758678007584 dimerization interface [polypeptide binding]; other site 758678007585 active site 758678007586 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 758678007587 Lumazine binding domain; Region: Lum_binding; pfam00677 758678007588 Lumazine binding domain; Region: Lum_binding; pfam00677 758678007589 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 758678007590 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 758678007591 catalytic motif [active] 758678007592 Zn binding site [ion binding]; other site 758678007593 RibD C-terminal domain; Region: RibD_C; cl17279 758678007594 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 758678007595 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 758678007596 metal binding site [ion binding]; metal-binding site 758678007597 dimer interface [polypeptide binding]; other site 758678007598 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678007599 magnesium-transporting ATPase; Provisional; Region: PRK15122 758678007600 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 758678007601 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678007602 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 758678007603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678007604 motif II; other site 758678007605 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 758678007606 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 758678007607 active site 758678007608 Spore germination protein; Region: Spore_permease; cl17796 758678007609 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 758678007610 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 758678007611 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 758678007612 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 758678007613 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 758678007614 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 758678007615 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 758678007616 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 758678007617 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 758678007618 purine monophosphate binding site [chemical binding]; other site 758678007619 dimer interface [polypeptide binding]; other site 758678007620 putative catalytic residues [active] 758678007621 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 758678007622 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 758678007623 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 758678007624 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 758678007625 active site 758678007626 substrate binding site [chemical binding]; other site 758678007627 cosubstrate binding site; other site 758678007628 catalytic site [active] 758678007629 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 758678007630 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 758678007631 dimerization interface [polypeptide binding]; other site 758678007632 putative ATP binding site [chemical binding]; other site 758678007633 amidophosphoribosyltransferase; Provisional; Region: PRK05793 758678007634 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 758678007635 active site 758678007636 tetramer interface [polypeptide binding]; other site 758678007637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678007638 active site 758678007639 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 758678007640 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 758678007641 ATP binding site [chemical binding]; other site 758678007642 active site 758678007643 substrate binding site [chemical binding]; other site 758678007644 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 758678007645 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 758678007646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758678007647 catalytic loop [active] 758678007648 iron binding site [ion binding]; other site 758678007649 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758678007650 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758678007651 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758678007652 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 758678007653 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 758678007654 putative metal binding site [ion binding]; other site 758678007655 putative dimer interface [polypeptide binding]; other site 758678007656 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 758678007657 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 758678007658 active site 758678007659 putative substrate binding pocket [chemical binding]; other site 758678007660 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 758678007661 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758678007662 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758678007663 phenylhydantoinase; Validated; Region: PRK08323 758678007664 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 758678007665 tetramer interface [polypeptide binding]; other site 758678007666 active site 758678007667 xanthine permease; Region: pbuX; TIGR03173 758678007668 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 758678007669 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 758678007670 Ligand binding site; other site 758678007671 metal-binding site 758678007672 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 758678007673 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 758678007674 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 758678007675 XdhC Rossmann domain; Region: XdhC_C; pfam13478 758678007676 NTPase; Region: NTPase_1; pfam03266 758678007677 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 758678007678 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758678007679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758678007680 ABC-ATPase subunit interface; other site 758678007681 dimer interface [polypeptide binding]; other site 758678007682 putative PBP binding regions; other site 758678007683 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758678007684 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758678007685 Walker A/P-loop; other site 758678007686 ATP binding site [chemical binding]; other site 758678007687 Q-loop/lid; other site 758678007688 ABC transporter signature motif; other site 758678007689 Walker B; other site 758678007690 D-loop; other site 758678007691 H-loop/switch region; other site 758678007692 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 758678007693 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678007694 intersubunit interface [polypeptide binding]; other site 758678007695 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 758678007696 active site 758678007697 catalytic triad [active] 758678007698 oxyanion hole [active] 758678007699 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758678007700 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758678007701 amino acid carrier protein; Region: agcS; TIGR00835 758678007702 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 758678007703 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758678007704 tetramer interface [polypeptide binding]; other site 758678007705 catalytic Zn binding site [ion binding]; other site 758678007706 NADP binding site [chemical binding]; other site 758678007707 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 758678007708 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 758678007709 Ligand Binding Site [chemical binding]; other site 758678007710 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 758678007711 putative metal binding site [ion binding]; other site 758678007712 putative dimer interface [polypeptide binding]; other site 758678007713 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 758678007714 Domain of unknown function DUF77; Region: DUF77; pfam01910 758678007715 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 758678007716 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 758678007717 amidophosphoribosyltransferase; Provisional; Region: PRK05793 758678007718 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 758678007719 active site 758678007720 tetramer interface [polypeptide binding]; other site 758678007721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678007722 active site 758678007723 Protein of unknown function (DUF503); Region: DUF503; pfam04456 758678007724 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 758678007725 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 758678007726 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758678007727 Walker A/P-loop; other site 758678007728 ATP binding site [chemical binding]; other site 758678007729 ABC transporter; Region: ABC_tran; pfam00005 758678007730 Q-loop/lid; other site 758678007731 ABC transporter signature motif; other site 758678007732 Walker B; other site 758678007733 D-loop; other site 758678007734 H-loop/switch region; other site 758678007735 Predicted transcriptional regulators [Transcription]; Region: COG1725 758678007736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678007737 DNA-binding site [nucleotide binding]; DNA binding site 758678007738 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 758678007739 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 758678007740 Ferredoxin [Energy production and conversion]; Region: COG1146 758678007741 4Fe-4S binding domain; Region: Fer4_6; pfam12837 758678007742 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758678007743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758678007744 ligand binding site [chemical binding]; other site 758678007745 flexible hinge region; other site 758678007746 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758678007747 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 758678007748 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 758678007749 Predicted membrane protein [Function unknown]; Region: COG1511 758678007750 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 758678007751 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 758678007752 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 758678007753 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 758678007754 active site 758678007755 catalytic site [active] 758678007756 metal binding site [ion binding]; metal-binding site 758678007757 dimer interface [polypeptide binding]; other site 758678007758 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 758678007759 Domain of unknown function DUF21; Region: DUF21; pfam01595 758678007760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 758678007761 Transporter associated domain; Region: CorC_HlyC; pfam03471 758678007762 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 758678007763 Putative zinc ribbon domain; Region: DUF164; pfam02591 758678007764 Uncharacterized conserved protein [Function unknown]; Region: COG0327 758678007765 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 758678007766 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 758678007767 Family of unknown function (DUF633); Region: DUF633; pfam04816 758678007768 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 758678007769 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 758678007770 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 758678007771 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 758678007772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678007773 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758678007774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678007775 DNA binding residues [nucleotide binding] 758678007776 DNA primase, catalytic core; Region: dnaG; TIGR01391 758678007777 CHC2 zinc finger; Region: zf-CHC2; pfam01807 758678007778 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 758678007779 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 758678007780 active site 758678007781 metal binding site [ion binding]; metal-binding site 758678007782 interdomain interaction site; other site 758678007783 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 758678007784 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 758678007785 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678007786 Zn2+ binding site [ion binding]; other site 758678007787 Mg2+ binding site [ion binding]; other site 758678007788 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 758678007789 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 758678007790 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 758678007791 pyruvate phosphate dikinase; Provisional; Region: PRK09279 758678007792 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 758678007793 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758678007794 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758678007795 HTH domain; Region: HTH_11; pfam08279 758678007796 FOG: CBS domain [General function prediction only]; Region: COG0517 758678007797 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 758678007798 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 758678007799 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 758678007800 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 758678007801 Recombination protein O C terminal; Region: RecO_C; pfam02565 758678007802 GTPase Era; Reviewed; Region: era; PRK00089 758678007803 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 758678007804 G1 box; other site 758678007805 GTP/Mg2+ binding site [chemical binding]; other site 758678007806 Switch I region; other site 758678007807 G2 box; other site 758678007808 Switch II region; other site 758678007809 G3 box; other site 758678007810 G4 box; other site 758678007811 G5 box; other site 758678007812 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 758678007813 active site 758678007814 catalytic motif [active] 758678007815 Zn binding site [ion binding]; other site 758678007816 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 758678007817 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 758678007818 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 758678007819 active site 758678007820 metal-binding heat shock protein; Provisional; Region: PRK00016 758678007821 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 758678007822 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 758678007823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678007824 Zn2+ binding site [ion binding]; other site 758678007825 Mg2+ binding site [ion binding]; other site 758678007826 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 758678007827 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 758678007828 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 758678007829 Yqey-like protein; Region: YqeY; pfam09424 758678007830 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 758678007831 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 758678007832 nucleotide binding site/active site [active] 758678007833 HIT family signature motif; other site 758678007834 catalytic residue [active] 758678007835 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 758678007836 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 758678007837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678007838 FeS/SAM binding site; other site 758678007839 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 758678007840 RNA methyltransferase, RsmE family; Region: TIGR00046 758678007841 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 758678007842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758678007843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678007844 S-adenosylmethionine binding site [chemical binding]; other site 758678007845 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 758678007846 substrate binding site [polypeptide binding]; other site 758678007847 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 758678007848 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 758678007849 Zn binding sites [ion binding]; other site 758678007850 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 758678007851 dimer interface [polypeptide binding]; other site 758678007852 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 758678007853 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 758678007854 nucleotide binding site [chemical binding]; other site 758678007855 NEF interaction site [polypeptide binding]; other site 758678007856 SBD interface [polypeptide binding]; other site 758678007857 GrpE; Region: GrpE; pfam01025 758678007858 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 758678007859 dimer interface [polypeptide binding]; other site 758678007860 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 758678007861 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 758678007862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 758678007863 DNA-binding site [nucleotide binding]; DNA binding site 758678007864 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 758678007865 HemN C-terminal domain; Region: HemN_C; pfam06969 758678007866 GTP-binding protein LepA; Provisional; Region: PRK05433 758678007867 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 758678007868 G1 box; other site 758678007869 putative GEF interaction site [polypeptide binding]; other site 758678007870 GTP/Mg2+ binding site [chemical binding]; other site 758678007871 Switch I region; other site 758678007872 G2 box; other site 758678007873 G3 box; other site 758678007874 Switch II region; other site 758678007875 G4 box; other site 758678007876 G5 box; other site 758678007877 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 758678007878 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 758678007879 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 758678007880 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 758678007881 stage II sporulation protein P; Region: spore_II_P; TIGR02867 758678007882 germination protease; Provisional; Region: PRK12362 758678007883 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 758678007884 Competence protein; Region: Competence; pfam03772 758678007885 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 758678007886 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 758678007887 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758678007888 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 758678007889 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 758678007890 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 758678007891 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 758678007892 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 758678007893 G1 box; other site 758678007894 putative GEF interaction site [polypeptide binding]; other site 758678007895 GTP/Mg2+ binding site [chemical binding]; other site 758678007896 Switch I region; other site 758678007897 G2 box; other site 758678007898 G3 box; other site 758678007899 Switch II region; other site 758678007900 G4 box; other site 758678007901 G5 box; other site 758678007902 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 758678007903 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 758678007904 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 758678007905 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 758678007906 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 758678007907 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 758678007908 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 758678007909 SLBB domain; Region: SLBB; pfam10531 758678007910 Helix-hairpin-helix motif; Region: HHH; pfam00633 758678007911 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 758678007912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678007913 RNA binding surface [nucleotide binding]; other site 758678007914 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 758678007915 active site 758678007916 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758678007917 homotrimer interaction site [polypeptide binding]; other site 758678007918 putative active site [active] 758678007919 Transcriptional regulator [Transcription]; Region: LytR; COG1316 758678007920 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 758678007921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678007922 Zn2+ binding site [ion binding]; other site 758678007923 Mg2+ binding site [ion binding]; other site 758678007924 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 758678007925 GTPase CgtA; Reviewed; Region: obgE; PRK12297 758678007926 GTP1/OBG; Region: GTP1_OBG; pfam01018 758678007927 Obg GTPase; Region: Obg; cd01898 758678007928 G1 box; other site 758678007929 GTP/Mg2+ binding site [chemical binding]; other site 758678007930 Switch I region; other site 758678007931 G2 box; other site 758678007932 G3 box; other site 758678007933 Switch II region; other site 758678007934 G4 box; other site 758678007935 G5 box; other site 758678007936 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 758678007937 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 758678007938 hypothetical protein; Provisional; Region: PRK14553 758678007939 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 758678007940 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 758678007941 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 758678007942 homodimer interface [polypeptide binding]; other site 758678007943 oligonucleotide binding site [chemical binding]; other site 758678007944 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 758678007945 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 758678007946 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 758678007947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678007948 FeS/SAM binding site; other site 758678007949 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758678007950 Peptidase family M23; Region: Peptidase_M23; pfam01551 758678007951 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 758678007952 cell division topological specificity factor MinE; Provisional; Region: PRK13987 758678007953 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 758678007954 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 758678007955 Switch I; other site 758678007956 Switch II; other site 758678007957 septum formation inhibitor; Reviewed; Region: minC; PRK00513 758678007958 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 758678007959 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758678007960 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758678007961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758678007962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758678007963 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 758678007964 rod shape-determining protein MreC; Provisional; Region: PRK13922 758678007965 rod shape-determining protein MreC; Region: MreC; pfam04085 758678007966 rod shape-determining protein MreB; Provisional; Region: PRK13927 758678007967 MreB and similar proteins; Region: MreB_like; cd10225 758678007968 nucleotide binding site [chemical binding]; other site 758678007969 Mg binding site [ion binding]; other site 758678007970 putative protofilament interaction site [polypeptide binding]; other site 758678007971 RodZ interaction site [polypeptide binding]; other site 758678007972 hypothetical protein; Reviewed; Region: PRK00024 758678007973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 758678007974 helix-hairpin-helix signature motif; other site 758678007975 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 758678007976 MPN+ (JAMM) motif; other site 758678007977 Zinc-binding site [ion binding]; other site 758678007978 Maf-like protein; Reviewed; Region: PRK00078 758678007979 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 758678007980 active site 758678007981 dimer interface [polypeptide binding]; other site 758678007982 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 758678007983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 758678007984 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 758678007985 hypothetical protein; Provisional; Region: PRK04435 758678007986 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 758678007987 DNA-binding interface [nucleotide binding]; DNA binding site 758678007988 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 758678007989 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758678007990 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758678007991 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758678007992 catalytic residue [active] 758678007993 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 758678007994 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 758678007995 CoA-binding site [chemical binding]; other site 758678007996 ATP-binding [chemical binding]; other site 758678007997 DNA polymerase I; Provisional; Region: PRK05755 758678007998 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 758678007999 active site 758678008000 metal binding site 1 [ion binding]; metal-binding site 758678008001 putative 5' ssDNA interaction site; other site 758678008002 metal binding site 3; metal-binding site 758678008003 metal binding site 2 [ion binding]; metal-binding site 758678008004 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 758678008005 putative DNA binding site [nucleotide binding]; other site 758678008006 putative metal binding site [ion binding]; other site 758678008007 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 758678008008 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 758678008009 active site 758678008010 DNA binding site [nucleotide binding] 758678008011 catalytic site [active] 758678008012 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 758678008013 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 758678008014 Tetramer interface [polypeptide binding]; other site 758678008015 active site 758678008016 FMN-binding site [chemical binding]; other site 758678008017 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678008018 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678008019 active site 758678008020 metal binding site [ion binding]; metal-binding site 758678008021 Bacterial SH3 domain; Region: SH3_3; pfam08239 758678008022 Haemolysin XhlA; Region: XhlA; pfam10779 758678008023 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 758678008024 Caspase domain; Region: Peptidase_C14; pfam00656 758678008025 DivIVA protein; Region: DivIVA; pfam05103 758678008026 hypothetical protein; Validated; Region: PRK08116 758678008027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758678008029 Walker A motif; other site 758678008030 ATP binding site [chemical binding]; other site 758678008031 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 758678008032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 758678008033 non-specific DNA binding site [nucleotide binding]; other site 758678008034 salt bridge; other site 758678008035 sequence-specific DNA binding site [nucleotide binding]; other site 758678008036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008037 non-specific DNA binding site [nucleotide binding]; other site 758678008038 salt bridge; other site 758678008039 sequence-specific DNA binding site [nucleotide binding]; other site 758678008040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678008041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008042 non-specific DNA binding site [nucleotide binding]; other site 758678008043 salt bridge; other site 758678008044 sequence-specific DNA binding site [nucleotide binding]; other site 758678008045 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 758678008046 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 758678008047 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 758678008048 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 758678008049 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 758678008050 dimer interface [polypeptide binding]; other site 758678008051 anticodon binding site; other site 758678008052 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 758678008053 homodimer interface [polypeptide binding]; other site 758678008054 motif 1; other site 758678008055 active site 758678008056 motif 2; other site 758678008057 GAD domain; Region: GAD; pfam02938 758678008058 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 758678008059 motif 3; other site 758678008060 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 758678008061 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 758678008062 dimer interface [polypeptide binding]; other site 758678008063 motif 1; other site 758678008064 active site 758678008065 motif 2; other site 758678008066 motif 3; other site 758678008067 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 758678008068 anticodon binding site; other site 758678008069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758678008070 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 758678008071 putative active site [active] 758678008072 dimerization interface [polypeptide binding]; other site 758678008073 putative tRNAtyr binding site [nucleotide binding]; other site 758678008074 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 758678008075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678008076 Zn2+ binding site [ion binding]; other site 758678008077 Mg2+ binding site [ion binding]; other site 758678008078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 758678008079 synthetase active site [active] 758678008080 NTP binding site [chemical binding]; other site 758678008081 metal binding site [ion binding]; metal-binding site 758678008082 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 758678008083 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 758678008084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678008085 active site 758678008086 DHH family; Region: DHH; pfam01368 758678008087 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 758678008088 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 758678008089 Protein export membrane protein; Region: SecD_SecF; pfam02355 758678008090 protein-export membrane protein SecD; Region: secD; TIGR01129 758678008091 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 758678008092 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 758678008093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678008094 FeS/SAM binding site; other site 758678008095 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 758678008096 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 758678008097 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 758678008098 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 758678008099 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 758678008100 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 758678008101 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 758678008102 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 758678008103 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 758678008104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008105 Walker A motif; other site 758678008106 ATP binding site [chemical binding]; other site 758678008107 Walker B motif; other site 758678008108 arginine finger; other site 758678008109 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 758678008110 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 758678008111 RuvA N terminal domain; Region: RuvA_N; pfam01330 758678008112 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 758678008113 hypothetical protein; Validated; Region: PRK00110 758678008114 Uncharacterized conserved protein [Function unknown]; Region: COG1739 758678008115 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 758678008116 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 758678008117 HEAT repeats; Region: HEAT_2; pfam13646 758678008118 HEAT-like repeat; Region: HEAT_EZ; pfam13513 758678008119 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758678008120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758678008121 DNA-binding site [nucleotide binding]; DNA binding site 758678008122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758678008123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678008124 homodimer interface [polypeptide binding]; other site 758678008125 catalytic residue [active] 758678008126 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 758678008127 Rubredoxin; Region: Rubredoxin; pfam00301 758678008128 iron binding site [ion binding]; other site 758678008129 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 758678008130 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 758678008131 HflX GTPase family; Region: HflX; cd01878 758678008132 G1 box; other site 758678008133 GTP/Mg2+ binding site [chemical binding]; other site 758678008134 Switch I region; other site 758678008135 G2 box; other site 758678008136 G3 box; other site 758678008137 Switch II region; other site 758678008138 G4 box; other site 758678008139 G5 box; other site 758678008140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678008141 active site 758678008142 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 758678008143 Transglycosylase; Region: Transgly; pfam00912 758678008144 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 758678008145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758678008146 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 758678008147 stage V sporulation protein AD; Validated; Region: PRK08304 758678008148 stage V sporulation protein AD; Provisional; Region: PRK12404 758678008149 SpoVA protein; Region: SpoVA; cl04298 758678008150 sporulation sigma factor SigF; Validated; Region: PRK05572 758678008151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678008152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758678008153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678008154 DNA binding residues [nucleotide binding] 758678008155 anti-sigma F factor; Provisional; Region: PRK03660 758678008156 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 758678008157 ATP binding site [chemical binding]; other site 758678008158 Mg2+ binding site [ion binding]; other site 758678008159 G-X-G motif; other site 758678008160 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 758678008161 anti sigma factor interaction site; other site 758678008162 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758678008163 regulatory phosphorylation site [posttranslational modification]; other site 758678008164 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 758678008165 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 758678008166 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 758678008167 NodB motif; other site 758678008168 active site 758678008169 catalytic site [active] 758678008170 Cd binding site [ion binding]; other site 758678008171 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 758678008172 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 758678008173 Bacterial sugar transferase; Region: Bac_transf; pfam02397 758678008174 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758678008175 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 758678008176 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 758678008177 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 758678008178 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 758678008179 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758678008180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678008181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678008182 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 758678008183 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 758678008184 O-Antigen ligase; Region: Wzy_C; pfam04932 758678008185 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 758678008186 putative glycosyl transferase; Provisional; Region: PRK10307 758678008187 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 758678008188 active site 758678008189 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 758678008190 homodimer interface [polypeptide binding]; other site 758678008191 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 758678008192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678008193 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758678008194 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 758678008195 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678008196 Leucine-rich repeats; other site 758678008197 Substrate binding site [chemical binding]; other site 758678008198 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678008199 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678008200 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678008201 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 758678008202 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758678008203 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 758678008204 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 758678008205 putative trimer interface [polypeptide binding]; other site 758678008206 putative CoA binding site [chemical binding]; other site 758678008207 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 758678008208 putative trimer interface [polypeptide binding]; other site 758678008209 putative active site [active] 758678008210 putative substrate binding site [chemical binding]; other site 758678008211 putative CoA binding site [chemical binding]; other site 758678008212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758678008213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758678008214 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758678008215 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 758678008216 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 758678008217 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 758678008218 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 758678008219 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 758678008220 NAD(P) binding site [chemical binding]; other site 758678008221 homodimer interface [polypeptide binding]; other site 758678008222 substrate binding site [chemical binding]; other site 758678008223 active site 758678008224 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 758678008225 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 758678008226 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008227 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008228 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008229 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008230 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678008231 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678008232 active site 758678008233 metal binding site [ion binding]; metal-binding site 758678008234 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 758678008235 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678008236 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678008237 active site 758678008238 metal binding site [ion binding]; metal-binding site 758678008239 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 758678008240 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 758678008241 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 758678008242 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 758678008243 active site 758678008244 tetramer interface; other site 758678008245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678008246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678008247 binding surface 758678008248 TPR motif; other site 758678008249 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 758678008250 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 758678008251 active site 758678008252 substrate binding site [chemical binding]; other site 758678008253 metal binding site [ion binding]; metal-binding site 758678008254 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 758678008255 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 758678008256 5S rRNA interface [nucleotide binding]; other site 758678008257 CTC domain interface [polypeptide binding]; other site 758678008258 L16 interface [polypeptide binding]; other site 758678008259 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 758678008260 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 758678008261 homodimer interface [polypeptide binding]; other site 758678008262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678008263 catalytic residue [active] 758678008264 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 758678008265 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 758678008266 Uncharacterized conserved protein [Function unknown]; Region: COG1683 758678008267 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 758678008268 MutS domain III; Region: MutS_III; pfam05192 758678008269 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 758678008270 Walker A/P-loop; other site 758678008271 ATP binding site [chemical binding]; other site 758678008272 Q-loop/lid; other site 758678008273 ABC transporter signature motif; other site 758678008274 Walker B; other site 758678008275 D-loop; other site 758678008276 H-loop/switch region; other site 758678008277 Smr domain; Region: Smr; pfam01713 758678008278 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 758678008279 Peptidase family U32; Region: Peptidase_U32; pfam01136 758678008280 Collagenase; Region: DUF3656; pfam12392 758678008281 Peptidase family U32; Region: Peptidase_U32; cl03113 758678008282 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 758678008283 putative metal binding site; other site 758678008284 Cell division protein ZapA; Region: ZapA; pfam05164 758678008285 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 758678008286 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 758678008287 putative tRNA-binding site [nucleotide binding]; other site 758678008288 B3/4 domain; Region: B3_4; pfam03483 758678008289 tRNA synthetase B5 domain; Region: B5; smart00874 758678008290 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 758678008291 dimer interface [polypeptide binding]; other site 758678008292 motif 1; other site 758678008293 motif 3; other site 758678008294 motif 2; other site 758678008295 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 758678008296 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 758678008297 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 758678008298 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 758678008299 dimer interface [polypeptide binding]; other site 758678008300 motif 1; other site 758678008301 active site 758678008302 motif 2; other site 758678008303 motif 3; other site 758678008304 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 758678008305 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 758678008306 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 758678008307 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 758678008308 TrkA-N domain; Region: TrkA_N; pfam02254 758678008309 TrkA-C domain; Region: TrkA_C; pfam02080 758678008310 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 758678008311 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 758678008312 23S rRNA binding site [nucleotide binding]; other site 758678008313 L21 binding site [polypeptide binding]; other site 758678008314 L13 binding site [polypeptide binding]; other site 758678008315 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 758678008316 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 758678008317 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 758678008318 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 758678008319 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 758678008320 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 758678008321 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 758678008322 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 758678008323 active site 758678008324 dimer interface [polypeptide binding]; other site 758678008325 motif 1; other site 758678008326 motif 2; other site 758678008327 motif 3; other site 758678008328 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 758678008329 anticodon binding site; other site 758678008330 YtxC-like family; Region: YtxC; pfam08812 758678008331 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 758678008332 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 758678008333 dimerization interface [polypeptide binding]; other site 758678008334 domain crossover interface; other site 758678008335 redox-dependent activation switch; other site 758678008336 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 758678008337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678008338 S-adenosylmethionine binding site [chemical binding]; other site 758678008339 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 758678008340 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 758678008341 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758678008342 Walker A/P-loop; other site 758678008343 ATP binding site [chemical binding]; other site 758678008344 Q-loop/lid; other site 758678008345 ABC transporter signature motif; other site 758678008346 Walker B; other site 758678008347 D-loop; other site 758678008348 H-loop/switch region; other site 758678008349 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758678008350 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 758678008351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758678008352 Walker A/P-loop; other site 758678008353 ATP binding site [chemical binding]; other site 758678008354 Q-loop/lid; other site 758678008355 ABC transporter signature motif; other site 758678008356 Walker B; other site 758678008357 D-loop; other site 758678008358 H-loop/switch region; other site 758678008359 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 758678008360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758678008361 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 758678008362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678008363 putative PBP binding loops; other site 758678008364 dimer interface [polypeptide binding]; other site 758678008365 ABC-ATPase subunit interface; other site 758678008366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758678008367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678008368 dimer interface [polypeptide binding]; other site 758678008369 conserved gate region; other site 758678008370 putative PBP binding loops; other site 758678008371 ABC-ATPase subunit interface; other site 758678008372 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 758678008373 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 758678008374 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758678008375 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 758678008376 dimer interface [polypeptide binding]; other site 758678008377 active site 758678008378 catalytic residue [active] 758678008379 dihydrodipicolinate reductase; Provisional; Region: PRK00048 758678008380 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 758678008381 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 758678008382 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 758678008383 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 758678008384 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 758678008385 trimer interface [polypeptide binding]; other site 758678008386 active site 758678008387 substrate binding site [chemical binding]; other site 758678008388 CoA binding site [chemical binding]; other site 758678008389 single-stranded DNA-binding protein; Provisional; Region: PRK05813 758678008390 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 758678008391 dimer interface [polypeptide binding]; other site 758678008392 ssDNA binding site [nucleotide binding]; other site 758678008393 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678008394 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 758678008395 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 758678008396 uncharacterized protein TIGR03905; Region: TIGR03905_4_Cys 758678008397 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 758678008398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678008399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758678008400 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 758678008401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758678008402 active site 758678008403 HIGH motif; other site 758678008404 nucleotide binding site [chemical binding]; other site 758678008405 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 758678008406 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 758678008407 active site 758678008408 KMSKS motif; other site 758678008409 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 758678008410 tRNA binding surface [nucleotide binding]; other site 758678008411 anticodon binding site; other site 758678008412 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 758678008413 putative acetyltransferase YhhY; Provisional; Region: PRK10140 758678008414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678008415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758678008416 Coenzyme A binding pocket [chemical binding]; other site 758678008417 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 758678008418 active site 758678008419 catalytic triad [active] 758678008420 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 758678008421 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 758678008422 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 758678008423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678008424 FeS/SAM binding site; other site 758678008425 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 758678008426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758678008427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678008428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678008429 Walker A/P-loop; other site 758678008430 ATP binding site [chemical binding]; other site 758678008431 Q-loop/lid; other site 758678008432 ABC transporter signature motif; other site 758678008433 Walker B; other site 758678008434 D-loop; other site 758678008435 H-loop/switch region; other site 758678008436 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758678008437 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758678008438 Walker A/P-loop; other site 758678008439 ATP binding site [chemical binding]; other site 758678008440 Q-loop/lid; other site 758678008441 ABC transporter signature motif; other site 758678008442 Walker B; other site 758678008443 D-loop; other site 758678008444 H-loop/switch region; other site 758678008445 NMT1/THI5 like; Region: NMT1; pfam09084 758678008446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008447 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678008448 non-specific DNA binding site [nucleotide binding]; other site 758678008449 salt bridge; other site 758678008450 sequence-specific DNA binding site [nucleotide binding]; other site 758678008451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008452 sequence-specific DNA binding site [nucleotide binding]; other site 758678008453 salt bridge; other site 758678008454 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 758678008455 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 758678008456 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758678008457 Walker A motif; other site 758678008458 ATP binding site [chemical binding]; other site 758678008459 Walker B motif; other site 758678008460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008461 sequence-specific DNA binding site [nucleotide binding]; other site 758678008462 salt bridge; other site 758678008463 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 758678008464 Resolvase, N terminal domain; Region: Resolvase; smart00857 758678008465 catalytic residues [active] 758678008466 catalytic nucleophile [active] 758678008467 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 758678008468 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 758678008469 substrate binding site [chemical binding]; other site 758678008470 amidase catalytic site [active] 758678008471 Zn binding residues [ion binding]; other site 758678008472 Bacterial SH3 domain; Region: SH3_3; cl17532 758678008473 Bacterial SH3 domain; Region: SH3_3; pfam08239 758678008474 Holin family; Region: Phage_holin_4; pfam05105 758678008475 Phage tail protein; Region: Sipho_tail; pfam05709 758678008476 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 758678008477 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 758678008478 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 758678008479 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 758678008480 oligomerization interface [polypeptide binding]; other site 758678008481 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 758678008482 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 758678008483 Phage capsid family; Region: Phage_capsid; pfam05065 758678008484 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 758678008485 oligomer interface [polypeptide binding]; other site 758678008486 Clp protease; Region: CLP_protease; pfam00574 758678008487 active site residues [active] 758678008488 potential frameshift: common BLAST hit: gi|153940986|ref|YP_001392482.1| HK97 family phage portal protein 758678008489 Phage portal protein; Region: Phage_portal; pfam04860 758678008490 Phage-related protein [Function unknown]; Region: COG4695; cl01923 758678008491 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 758678008492 Phage terminase, small subunit; Region: Terminase_4; pfam05119 758678008493 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 758678008494 Int/Topo IB signature motif; other site 758678008495 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 758678008496 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 758678008497 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 758678008498 Methyltransferase domain; Region: Methyltransf_25; pfam13649 758678008499 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 758678008500 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 758678008501 KTSC domain; Region: KTSC; pfam13619 758678008502 ORF6N domain; Region: ORF6N; pfam10543 758678008503 ORF6C domain; Region: ORF6C; pfam10552 758678008504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678008506 non-specific DNA binding site [nucleotide binding]; other site 758678008507 salt bridge; other site 758678008508 sequence-specific DNA binding site [nucleotide binding]; other site 758678008509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678008510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678008511 non-specific DNA binding site [nucleotide binding]; other site 758678008512 salt bridge; other site 758678008513 sequence-specific DNA binding site [nucleotide binding]; other site 758678008514 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758678008515 NMT1-like family; Region: NMT1_2; pfam13379 758678008516 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678008517 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 758678008518 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678008519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 758678008520 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678008521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 758678008522 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758678008523 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758678008524 Walker A/P-loop; other site 758678008525 ATP binding site [chemical binding]; other site 758678008526 Q-loop/lid; other site 758678008527 ABC transporter signature motif; other site 758678008528 Walker B; other site 758678008529 D-loop; other site 758678008530 H-loop/switch region; other site 758678008531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758678008532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678008533 dimer interface [polypeptide binding]; other site 758678008534 conserved gate region; other site 758678008535 putative PBP binding loops; other site 758678008536 ABC-ATPase subunit interface; other site 758678008537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678008538 TPR repeat; Region: TPR_11; pfam13414 758678008539 binding surface 758678008540 TPR motif; other site 758678008541 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758678008542 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758678008543 recombination regulator RecX; Provisional; Region: recX; PRK14134 758678008544 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 758678008545 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 758678008546 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 758678008547 QueT transporter; Region: QueT; pfam06177 758678008548 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 758678008549 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 758678008550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 758678008551 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758678008552 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758678008553 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 758678008554 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 758678008555 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 758678008556 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 758678008557 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 758678008558 dimer interface [polypeptide binding]; other site 758678008559 active site 758678008560 glycine loop; other site 758678008561 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 758678008562 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678008563 sequence-specific DNA binding site [nucleotide binding]; other site 758678008564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 758678008565 salt bridge; other site 758678008566 Cupin domain; Region: Cupin_2; pfam07883 758678008567 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 758678008568 Dimer interface [polypeptide binding]; other site 758678008569 BRCT sequence motif; other site 758678008570 agmatine deiminase; Region: agmatine_aguA; TIGR03380 758678008571 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 758678008572 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 758678008573 metal ion-dependent adhesion site (MIDAS); other site 758678008574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008575 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 758678008576 Walker A motif; other site 758678008577 ATP binding site [chemical binding]; other site 758678008578 Walker B motif; other site 758678008579 arginine finger; other site 758678008580 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 758678008581 Uncharacterized conserved protein [Function unknown]; Region: COG1915 758678008582 Uncharacterized conserved protein [Function unknown]; Region: COG1915 758678008583 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 758678008584 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 758678008585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 758678008586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 758678008587 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 758678008588 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678008589 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 758678008590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008591 Walker A motif; other site 758678008592 ATP binding site [chemical binding]; other site 758678008593 Walker B motif; other site 758678008594 arginine finger; other site 758678008595 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758678008596 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758678008597 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 758678008598 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758678008599 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 758678008600 Ligand binding site [chemical binding]; other site 758678008601 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758678008602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758678008603 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 758678008604 FAD binding site [chemical binding]; other site 758678008605 homotetramer interface [polypeptide binding]; other site 758678008606 substrate binding pocket [chemical binding]; other site 758678008607 catalytic base [active] 758678008608 putative acyltransferase; Provisional; Region: PRK05790 758678008609 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758678008610 dimer interface [polypeptide binding]; other site 758678008611 active site 758678008612 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 758678008613 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758678008614 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758678008615 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 758678008616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758678008617 substrate binding site [chemical binding]; other site 758678008618 oxyanion hole (OAH) forming residues; other site 758678008619 trimer interface [polypeptide binding]; other site 758678008620 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 758678008621 GIY-YIG motif/motif A; other site 758678008622 active site 758678008623 catalytic site [active] 758678008624 putative DNA binding site [nucleotide binding]; other site 758678008625 metal binding site [ion binding]; metal-binding site 758678008626 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758678008627 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 758678008628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678008629 Zn2+ binding site [ion binding]; other site 758678008630 Mg2+ binding site [ion binding]; other site 758678008631 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 758678008632 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 758678008633 homotetramer interface [polypeptide binding]; other site 758678008634 active site 758678008635 metal binding site [ion binding]; metal-binding site 758678008636 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 758678008637 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 758678008638 active site 758678008639 catalytic site [active] 758678008640 metal binding site [ion binding]; metal-binding site 758678008641 dimer interface [polypeptide binding]; other site 758678008642 Cache domain; Region: Cache_1; pfam02743 758678008643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678008644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678008645 dimer interface [polypeptide binding]; other site 758678008646 putative CheW interface [polypeptide binding]; other site 758678008647 Rubredoxin [Energy production and conversion]; Region: COG1773 758678008648 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 758678008649 iron binding site [ion binding]; other site 758678008650 Rubrerythrin [Energy production and conversion]; Region: COG1592 758678008651 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 758678008652 diiron binding motif [ion binding]; other site 758678008653 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 758678008654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678008655 FeS/SAM binding site; other site 758678008656 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 758678008657 Pyruvate formate lyase 1; Region: PFL1; cd01678 758678008658 coenzyme A binding site [chemical binding]; other site 758678008659 active site 758678008660 catalytic residues [active] 758678008661 glycine loop; other site 758678008662 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 758678008663 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 758678008664 5S rRNA interface [nucleotide binding]; other site 758678008665 CTC domain interface [polypeptide binding]; other site 758678008666 L16 interface [polypeptide binding]; other site 758678008667 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758678008668 metal binding site 2 [ion binding]; metal-binding site 758678008669 putative DNA binding helix; other site 758678008670 metal binding site 1 [ion binding]; metal-binding site 758678008671 dimer interface [polypeptide binding]; other site 758678008672 structural Zn2+ binding site [ion binding]; other site 758678008673 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758678008674 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758678008675 Predicted transcriptional regulator [Transcription]; Region: COG2378 758678008676 HTH domain; Region: HTH_11; pfam08279 758678008677 WYL domain; Region: WYL; pfam13280 758678008678 CAAX protease self-immunity; Region: Abi; pfam02517 758678008679 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 758678008680 G1 box; other site 758678008681 GTP/Mg2+ binding site [chemical binding]; other site 758678008682 Switch I region; other site 758678008683 G2 box; other site 758678008684 G3 box; other site 758678008685 Switch II region; other site 758678008686 G4 box; other site 758678008687 G5 box; other site 758678008688 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 758678008689 Found in ATP-dependent protease La (LON); Region: LON; smart00464 758678008690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008691 Walker A motif; other site 758678008692 ATP binding site [chemical binding]; other site 758678008693 Walker B motif; other site 758678008694 arginine finger; other site 758678008695 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 758678008696 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 758678008697 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 758678008698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678008699 Walker A motif; other site 758678008700 ATP binding site [chemical binding]; other site 758678008701 Walker B motif; other site 758678008702 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 758678008703 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 758678008704 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 758678008705 oligomer interface [polypeptide binding]; other site 758678008706 active site residues [active] 758678008707 trigger factor; Provisional; Region: tig; PRK01490 758678008708 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 758678008709 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 758678008710 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 758678008711 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 758678008712 DNA interaction; other site 758678008713 Metal-binding active site; metal-binding site 758678008714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678008715 active site 758678008716 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 758678008717 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 758678008718 heterodimer interface [polypeptide binding]; other site 758678008719 active site 758678008720 FMN binding site [chemical binding]; other site 758678008721 homodimer interface [polypeptide binding]; other site 758678008722 substrate binding site [chemical binding]; other site 758678008723 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 758678008724 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 758678008725 FAD binding pocket [chemical binding]; other site 758678008726 FAD binding motif [chemical binding]; other site 758678008727 phosphate binding motif [ion binding]; other site 758678008728 beta-alpha-beta structure motif; other site 758678008729 NAD binding pocket [chemical binding]; other site 758678008730 Iron coordination center [ion binding]; other site 758678008731 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 758678008732 active site 758678008733 dimer interface [polypeptide binding]; other site 758678008734 dihydroorotase; Validated; Region: pyrC; PRK09357 758678008735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758678008736 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 758678008737 active site 758678008738 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 758678008739 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 758678008740 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 758678008741 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 758678008742 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758678008743 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758678008744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678008745 nucleotide binding site [chemical binding]; other site 758678008746 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 758678008747 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 758678008748 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678008749 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678008750 DsrE/DsrF-like family; Region: DrsE; cl00672 758678008751 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758678008752 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758678008753 Walker A/P-loop; other site 758678008754 ATP binding site [chemical binding]; other site 758678008755 Q-loop/lid; other site 758678008756 ABC transporter signature motif; other site 758678008757 Walker B; other site 758678008758 D-loop; other site 758678008759 H-loop/switch region; other site 758678008760 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758678008761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758678008762 dimer interface [polypeptide binding]; other site 758678008763 conserved gate region; other site 758678008764 ABC-ATPase subunit interface; other site 758678008765 Alkylmercury lyase; Region: MerB; pfam03243 758678008766 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758678008767 NMT1-like family; Region: NMT1_2; pfam13379 758678008768 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 758678008769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758678008770 active site 758678008771 metal binding site [ion binding]; metal-binding site 758678008772 homotetramer interface [polypeptide binding]; other site 758678008773 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 758678008774 active site 758678008775 dimerization interface [polypeptide binding]; other site 758678008776 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 758678008777 peptide binding site [polypeptide binding]; other site 758678008778 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 758678008779 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 758678008780 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 758678008781 GatB domain; Region: GatB_Yqey; smart00845 758678008782 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 758678008783 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 758678008784 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 758678008785 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758678008786 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 758678008787 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 758678008788 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 758678008789 nucleotide binding pocket [chemical binding]; other site 758678008790 K-X-D-G motif; other site 758678008791 catalytic site [active] 758678008792 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 758678008793 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 758678008794 Helix-hairpin-helix motif; Region: HHH; pfam00633 758678008795 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 758678008796 Dimer interface [polypeptide binding]; other site 758678008797 Trp repressor protein; Region: Trp_repressor; cl17266 758678008798 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 758678008799 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678008800 RNA binding surface [nucleotide binding]; other site 758678008801 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 758678008802 active site 758678008803 uracil binding [chemical binding]; other site 758678008804 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 758678008805 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758678008806 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758678008807 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758678008808 catalytic residue [active] 758678008809 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 758678008810 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008811 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008812 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008813 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 758678008814 hypothetical protein; Validated; Region: PRK00124 758678008815 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 758678008816 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 758678008817 active site 758678008818 dimer interface [polypeptide binding]; other site 758678008819 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 758678008820 dimer interface [polypeptide binding]; other site 758678008821 active site 758678008822 Probable zinc-binding domain; Region: zf-trcl; pfam13451 758678008823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678008824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758678008825 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758678008826 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758678008827 Coenzyme A binding pocket [chemical binding]; other site 758678008828 D-lactate dehydrogenase; Validated; Region: PRK08605 758678008829 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 758678008830 homodimer interface [polypeptide binding]; other site 758678008831 ligand binding site [chemical binding]; other site 758678008832 NAD binding site [chemical binding]; other site 758678008833 catalytic site [active] 758678008834 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758678008835 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 758678008836 putative ligand binding site [chemical binding]; other site 758678008837 putative NAD binding site [chemical binding]; other site 758678008838 catalytic site [active] 758678008839 Uncharacterized membrane protein [Function unknown]; Region: COG3949 758678008840 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758678008841 4Fe-4S binding domain; Region: Fer4; pfam00037 758678008842 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758678008843 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 758678008844 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758678008845 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 758678008846 Ligand binding site [chemical binding]; other site 758678008847 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758678008848 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 758678008849 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678008850 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 758678008851 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678008852 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 758678008853 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 758678008854 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758678008855 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758678008856 AMP-binding domain protein; Validated; Region: PRK08315 758678008857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758678008858 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 758678008859 acyl-activating enzyme (AAE) consensus motif; other site 758678008860 putative AMP binding site [chemical binding]; other site 758678008861 putative active site [active] 758678008862 putative CoA binding site [chemical binding]; other site 758678008863 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 758678008864 GMP synthase; Reviewed; Region: guaA; PRK00074 758678008865 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 758678008866 AMP/PPi binding site [chemical binding]; other site 758678008867 candidate oxyanion hole; other site 758678008868 catalytic triad [active] 758678008869 potential glutamine specificity residues [chemical binding]; other site 758678008870 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 758678008871 ATP Binding subdomain [chemical binding]; other site 758678008872 Ligand Binding sites [chemical binding]; other site 758678008873 Dimerization subdomain; other site 758678008874 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 758678008875 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758678008876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 758678008877 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 758678008878 active site 758678008879 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 758678008880 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 758678008881 Ligand Binding Site [chemical binding]; other site 758678008882 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 758678008883 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 758678008884 ring oligomerisation interface [polypeptide binding]; other site 758678008885 ATP/Mg binding site [chemical binding]; other site 758678008886 stacking interactions; other site 758678008887 hinge regions; other site 758678008888 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 758678008889 oligomerisation interface [polypeptide binding]; other site 758678008890 mobile loop; other site 758678008891 roof hairpin; other site 758678008892 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 758678008893 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758678008894 Uncharacterized conserved protein [Function unknown]; Region: COG0398 758678008895 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 758678008896 4Fe-4S binding domain; Region: Fer4; pfam00037 758678008897 4Fe-4S binding domain; Region: Fer4; pfam00037 758678008898 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 758678008899 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 758678008900 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 758678008901 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758678008902 minor groove reading motif; other site 758678008903 helix-hairpin-helix signature motif; other site 758678008904 substrate binding pocket [chemical binding]; other site 758678008905 active site 758678008906 putative oxidoreductase; Provisional; Region: PRK12831 758678008907 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678008908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678008909 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 758678008910 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 758678008911 FAD binding pocket [chemical binding]; other site 758678008912 FAD binding motif [chemical binding]; other site 758678008913 phosphate binding motif [ion binding]; other site 758678008914 beta-alpha-beta structure motif; other site 758678008915 NAD binding pocket [chemical binding]; other site 758678008916 Iron coordination center [ion binding]; other site 758678008917 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 758678008918 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 758678008919 CoA binding domain; Region: CoA_binding; pfam02629 758678008920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 758678008921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678008922 Walker A/P-loop; other site 758678008923 ATP binding site [chemical binding]; other site 758678008924 Q-loop/lid; other site 758678008925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678008926 ABC transporter; Region: ABC_tran_2; pfam12848 758678008927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758678008928 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 758678008929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678008930 active site 758678008931 phosphorylation site [posttranslational modification] 758678008932 intermolecular recognition site; other site 758678008933 dimerization interface [polypeptide binding]; other site 758678008934 LytTr DNA-binding domain; Region: LytTR; pfam04397 758678008935 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 758678008936 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 758678008937 Histidine kinase; Region: His_kinase; pfam06580 758678008938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678008939 ATP binding site [chemical binding]; other site 758678008940 Mg2+ binding site [ion binding]; other site 758678008941 G-X-G motif; other site 758678008942 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 758678008943 Carbon starvation protein CstA; Region: CstA; pfam02554 758678008944 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 758678008945 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 758678008946 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 758678008947 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 758678008948 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 758678008949 Peptidase M16C associated; Region: M16C_assoc; pfam08367 758678008950 pyruvate carboxylase; Reviewed; Region: PRK12999 758678008951 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758678008952 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 758678008953 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 758678008954 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 758678008955 active site 758678008956 catalytic residues [active] 758678008957 metal binding site [ion binding]; metal-binding site 758678008958 homodimer binding site [polypeptide binding]; other site 758678008959 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758678008960 carboxyltransferase (CT) interaction site; other site 758678008961 biotinylation site [posttranslational modification]; other site 758678008962 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 758678008963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758678008964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758678008965 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 758678008966 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 758678008967 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 758678008968 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 758678008969 intersubunit interface [polypeptide binding]; other site 758678008970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678008971 Zn2+ binding site [ion binding]; other site 758678008972 Mg2+ binding site [ion binding]; other site 758678008973 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 758678008974 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758678008975 Zn2+ binding site [ion binding]; other site 758678008976 Mg2+ binding site [ion binding]; other site 758678008977 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 758678008978 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 758678008979 Glycoprotease family; Region: Peptidase_M22; pfam00814 758678008980 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 758678008981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678008982 Coenzyme A binding pocket [chemical binding]; other site 758678008983 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 758678008984 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 758678008985 active site 758678008986 HIGH motif; other site 758678008987 dimer interface [polypeptide binding]; other site 758678008988 KMSKS motif; other site 758678008989 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678008990 RNA binding surface [nucleotide binding]; other site 758678008991 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 758678008992 Divergent AAA domain; Region: AAA_4; pfam04326 758678008993 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 758678008994 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 758678008995 active site 758678008996 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 758678008997 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 758678008998 G1 box; other site 758678008999 putative GEF interaction site [polypeptide binding]; other site 758678009000 GTP/Mg2+ binding site [chemical binding]; other site 758678009001 Switch I region; other site 758678009002 G2 box; other site 758678009003 G3 box; other site 758678009004 Switch II region; other site 758678009005 G4 box; other site 758678009006 G5 box; other site 758678009007 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 758678009008 sugar phosphate phosphatase; Provisional; Region: PRK10513 758678009009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678009010 active site 758678009011 motif I; other site 758678009012 motif II; other site 758678009013 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758678009014 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 758678009015 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 758678009016 active site 758678009017 HIGH motif; other site 758678009018 dimer interface [polypeptide binding]; other site 758678009019 KMSKS motif; other site 758678009020 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 758678009021 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 758678009022 non-heme iron binding site [ion binding]; other site 758678009023 dimer interface [polypeptide binding]; other site 758678009024 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 758678009025 non-heme iron binding site [ion binding]; other site 758678009026 dimer interface [polypeptide binding]; other site 758678009027 diaminopimelate decarboxylase; Region: lysA; TIGR01048 758678009028 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 758678009029 active site 758678009030 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678009031 substrate binding site [chemical binding]; other site 758678009032 catalytic residues [active] 758678009033 dimer interface [polypeptide binding]; other site 758678009034 aspartate kinase; Reviewed; Region: PRK06635 758678009035 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 758678009036 putative catalytic residues [active] 758678009037 putative nucleotide binding site [chemical binding]; other site 758678009038 putative aspartate binding site [chemical binding]; other site 758678009039 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 758678009040 putative allosteric regulatory site; other site 758678009041 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 758678009042 putative allosteric regulatory residue; other site 758678009043 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 758678009044 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 758678009045 active site 758678009046 metal binding site [ion binding]; metal-binding site 758678009047 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 758678009048 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 758678009049 hypothetical protein; Provisional; Region: PRK06851 758678009050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758678009051 Walker A motif; other site 758678009052 ATP binding site [chemical binding]; other site 758678009053 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 758678009054 Part of AAA domain; Region: AAA_19; pfam13245 758678009055 FtsH Extracellular; Region: FtsH_ext; pfam06480 758678009056 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 758678009057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009058 Walker A motif; other site 758678009059 ATP binding site [chemical binding]; other site 758678009060 Walker B motif; other site 758678009061 arginine finger; other site 758678009062 Peptidase family M41; Region: Peptidase_M41; pfam01434 758678009063 dipeptidase PepV; Reviewed; Region: PRK07318 758678009064 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 758678009065 active site 758678009066 metal binding site [ion binding]; metal-binding site 758678009067 prolyl-tRNA synthetase; Provisional; Region: PRK08661 758678009068 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 758678009069 dimer interface [polypeptide binding]; other site 758678009070 motif 1; other site 758678009071 active site 758678009072 motif 2; other site 758678009073 motif 3; other site 758678009074 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 758678009075 anticodon binding site; other site 758678009076 zinc-binding site [ion binding]; other site 758678009077 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 758678009078 GIY-YIG motif/motif A; other site 758678009079 putative active site [active] 758678009080 putative metal binding site [ion binding]; other site 758678009081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678009082 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 758678009083 Walker A/P-loop; other site 758678009084 ATP binding site [chemical binding]; other site 758678009085 Q-loop/lid; other site 758678009086 ABC transporter signature motif; other site 758678009087 Walker B; other site 758678009088 D-loop; other site 758678009089 H-loop/switch region; other site 758678009090 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 758678009091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678009092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758678009093 DNA binding residues [nucleotide binding] 758678009094 putative transporter; Provisional; Region: PRK11660 758678009095 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 758678009096 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758678009097 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 758678009098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678009099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758678009100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678009101 dimer interface [polypeptide binding]; other site 758678009102 phosphorylation site [posttranslational modification] 758678009103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678009104 ATP binding site [chemical binding]; other site 758678009105 Mg2+ binding site [ion binding]; other site 758678009106 G-X-G motif; other site 758678009107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678009108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678009109 active site 758678009110 phosphorylation site [posttranslational modification] 758678009111 intermolecular recognition site; other site 758678009112 dimerization interface [polypeptide binding]; other site 758678009113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678009114 DNA binding site [nucleotide binding] 758678009115 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 758678009116 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 758678009117 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758678009118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678009119 Walker A/P-loop; other site 758678009120 ATP binding site [chemical binding]; other site 758678009121 Q-loop/lid; other site 758678009122 ABC transporter signature motif; other site 758678009123 Walker B; other site 758678009124 D-loop; other site 758678009125 H-loop/switch region; other site 758678009126 Uncharacterized conserved protein [Function unknown]; Region: COG3589 758678009127 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 758678009128 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 758678009129 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 758678009130 methionine cluster; other site 758678009131 active site 758678009132 phosphorylation site [posttranslational modification] 758678009133 metal binding site [ion binding]; metal-binding site 758678009134 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 758678009135 active site 758678009136 P-loop; other site 758678009137 phosphorylation site [posttranslational modification] 758678009138 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 758678009139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009140 Walker A motif; other site 758678009141 ATP binding site [chemical binding]; other site 758678009142 Walker B motif; other site 758678009143 arginine finger; other site 758678009144 Transcriptional antiterminator [Transcription]; Region: COG3933 758678009145 PRD domain; Region: PRD; pfam00874 758678009146 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 758678009147 active pocket/dimerization site; other site 758678009148 active site 758678009149 phosphorylation site [posttranslational modification] 758678009150 PRD domain; Region: PRD; pfam00874 758678009151 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 758678009152 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 758678009153 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 758678009154 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 758678009155 NAD binding site [chemical binding]; other site 758678009156 sugar binding site [chemical binding]; other site 758678009157 divalent metal binding site [ion binding]; other site 758678009158 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678009159 dimer interface [polypeptide binding]; other site 758678009160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758678009161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758678009162 metal binding site [ion binding]; metal-binding site 758678009163 active site 758678009164 I-site; other site 758678009165 Phage integrase family; Region: Phage_integrase; pfam00589 758678009166 active site 758678009167 DNA binding site [nucleotide binding] 758678009168 Int/Topo IB signature motif; other site 758678009169 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 758678009170 Protein of unknown function DUF43; Region: DUF43; pfam01861 758678009171 Mor transcription activator family; Region: Mor; cl02360 758678009172 Predicted transcriptional regulators [Transcription]; Region: COG1733 758678009173 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 758678009174 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 758678009175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758678009176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758678009177 active site 758678009178 catalytic tetrad [active] 758678009179 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678009180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678009181 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 758678009182 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 758678009183 DNA binding residues [nucleotide binding] 758678009184 putative dimer interface [polypeptide binding]; other site 758678009185 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678009186 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678009187 Rrf2 family protein; Region: rrf2_super; TIGR00738 758678009188 Transcriptional regulator; Region: Rrf2; pfam02082 758678009189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758678009190 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758678009191 Coenzyme A binding pocket [chemical binding]; other site 758678009192 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 758678009193 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 758678009194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758678009195 S-adenosylmethionine binding site [chemical binding]; other site 758678009196 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 758678009197 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 758678009198 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 758678009199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758678009200 active site 758678009201 catalytic tetrad [active] 758678009202 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758678009203 pyruvate kinase; Provisional; Region: PRK06354 758678009204 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 758678009205 domain interfaces; other site 758678009206 active site 758678009207 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 758678009208 6-phosphofructokinase; Provisional; Region: PRK03202 758678009209 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 758678009210 active site 758678009211 ADP/pyrophosphate binding site [chemical binding]; other site 758678009212 dimerization interface [polypeptide binding]; other site 758678009213 allosteric effector site; other site 758678009214 fructose-1,6-bisphosphate binding site; other site 758678009215 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 758678009216 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 758678009217 active site 758678009218 PHP Thumb interface [polypeptide binding]; other site 758678009219 metal binding site [ion binding]; metal-binding site 758678009220 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 758678009221 generic binding surface II; other site 758678009222 generic binding surface I; other site 758678009223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 758678009224 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 758678009225 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 758678009226 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 758678009227 phosphate binding site [ion binding]; other site 758678009228 putative substrate binding pocket [chemical binding]; other site 758678009229 dimer interface [polypeptide binding]; other site 758678009230 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 758678009231 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 758678009232 FAD binding domain; Region: FAD_binding_4; pfam01565 758678009233 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 758678009234 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 758678009235 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 758678009236 active site 758678009237 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 758678009238 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 758678009239 GIY-YIG motif/motif A; other site 758678009240 active site 758678009241 catalytic site [active] 758678009242 putative DNA binding site [nucleotide binding]; other site 758678009243 metal binding site [ion binding]; metal-binding site 758678009244 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 758678009245 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 758678009246 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758678009247 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 758678009248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758678009249 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 758678009250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 758678009251 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 758678009252 phosphopeptide binding site; other site 758678009253 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 758678009254 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758678009255 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758678009256 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 758678009257 excinuclease ABC subunit B; Provisional; Region: PRK05298 758678009258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678009259 ATP binding site [chemical binding]; other site 758678009260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678009261 nucleotide binding region [chemical binding]; other site 758678009262 ATP-binding site [chemical binding]; other site 758678009263 Ultra-violet resistance protein B; Region: UvrB; pfam12344 758678009264 UvrB/uvrC motif; Region: UVR; pfam02151 758678009265 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 758678009266 C-terminal peptidase (prc); Region: prc; TIGR00225 758678009267 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 758678009268 protein binding site [polypeptide binding]; other site 758678009269 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 758678009270 Catalytic dyad [active] 758678009271 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 758678009272 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 758678009273 FtsX-like permease family; Region: FtsX; pfam02687 758678009274 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 758678009275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758678009276 Walker A/P-loop; other site 758678009277 ATP binding site [chemical binding]; other site 758678009278 Q-loop/lid; other site 758678009279 ABC transporter signature motif; other site 758678009280 Walker B; other site 758678009281 D-loop; other site 758678009282 H-loop/switch region; other site 758678009283 Uncharacterized conserved protein [Function unknown]; Region: COG1284 758678009284 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 758678009285 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 758678009286 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 758678009287 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758678009288 PYR/PP interface [polypeptide binding]; other site 758678009289 dimer interface [polypeptide binding]; other site 758678009290 TPP binding site [chemical binding]; other site 758678009291 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758678009292 transketolase; Reviewed; Region: PRK05899 758678009293 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758678009294 TPP-binding site [chemical binding]; other site 758678009295 dimer interface [polypeptide binding]; other site 758678009296 PemK-like protein; Region: PemK; pfam02452 758678009297 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 758678009298 alanine racemase; Reviewed; Region: alr; PRK00053 758678009299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 758678009300 active site 758678009301 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758678009302 dimer interface [polypeptide binding]; other site 758678009303 substrate binding site [chemical binding]; other site 758678009304 catalytic residues [active] 758678009305 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 758678009306 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 758678009307 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 758678009308 putative substrate binding site [chemical binding]; other site 758678009309 putative ATP binding site [chemical binding]; other site 758678009310 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 758678009311 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 758678009312 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 758678009313 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 758678009314 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 758678009315 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 758678009316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678009317 RNA binding surface [nucleotide binding]; other site 758678009318 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758678009319 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 758678009320 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758678009321 dinuclear metal binding motif [ion binding]; other site 758678009322 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 758678009323 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 758678009324 glutaminase active site [active] 758678009325 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 758678009326 dimer interface [polypeptide binding]; other site 758678009327 active site 758678009328 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 758678009329 dimer interface [polypeptide binding]; other site 758678009330 active site 758678009331 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 758678009332 active site 758678009333 intersubunit interactions; other site 758678009334 catalytic residue [active] 758678009335 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 758678009336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678009337 motif II; other site 758678009338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758678009339 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 758678009340 NAD(P) binding site [chemical binding]; other site 758678009341 active site 758678009342 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 758678009343 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 758678009344 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 758678009345 Nucleoside recognition; Region: Gate; pfam07670 758678009346 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 758678009347 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 758678009348 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 758678009349 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758678009350 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 758678009351 putative NAD(P) binding site [chemical binding]; other site 758678009352 catalytic Zn binding site [ion binding]; other site 758678009353 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 758678009354 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758678009355 non-specific DNA interactions [nucleotide binding]; other site 758678009356 DNA binding site [nucleotide binding] 758678009357 sequence specific DNA binding site [nucleotide binding]; other site 758678009358 putative cAMP binding site [chemical binding]; other site 758678009359 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 758678009360 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 758678009361 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 758678009362 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 758678009363 TPP-binding site [chemical binding]; other site 758678009364 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 758678009365 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758678009366 dimer interface [polypeptide binding]; other site 758678009367 PYR/PP interface [polypeptide binding]; other site 758678009368 TPP binding site [chemical binding]; other site 758678009369 substrate binding site [chemical binding]; other site 758678009370 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758678009371 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758678009372 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758678009373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758678009374 P-loop; other site 758678009375 Magnesium ion binding site [ion binding]; other site 758678009376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678009377 nucleotide binding site [chemical binding]; other site 758678009378 Acetokinase family; Region: Acetate_kinase; cl17229 758678009379 phosphate butyryltransferase; Validated; Region: PRK05805 758678009380 butyrate kinase; Provisional; Region: PRK03011 758678009381 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 758678009382 YbbR-like protein; Region: YbbR; pfam07949 758678009383 YbbR-like protein; Region: YbbR; pfam07949 758678009384 Uncharacterized conserved protein [Function unknown]; Region: COG1624 758678009385 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 758678009386 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 758678009387 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 758678009388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758678009389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758678009390 catalytic residues [active] 758678009391 isoaspartyl dipeptidase; Provisional; Region: PRK10657 758678009392 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758678009393 active site 758678009394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 758678009395 TPR motif; other site 758678009396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678009397 binding surface 758678009398 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 758678009399 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 758678009400 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758678009401 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758678009402 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 758678009403 dimerization domain swap beta strand [polypeptide binding]; other site 758678009404 regulatory protein interface [polypeptide binding]; other site 758678009405 active site 758678009406 regulatory phosphorylation site [posttranslational modification]; other site 758678009407 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 758678009408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678009409 putative active site [active] 758678009410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758678009411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009412 Walker A motif; other site 758678009413 ATP binding site [chemical binding]; other site 758678009414 Walker B motif; other site 758678009415 arginine finger; other site 758678009416 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 758678009417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758678009418 binding surface 758678009419 TPR motif; other site 758678009420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758678009421 fumarate hydratase; Provisional; Region: PRK06842 758678009422 fumarate hydratase; Provisional; Region: PRK06246 758678009423 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 758678009424 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758678009425 active site 758678009426 metal binding site [ion binding]; metal-binding site 758678009427 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 758678009428 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 758678009429 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 758678009430 PhoU domain; Region: PhoU; pfam01895 758678009431 PhoU domain; Region: PhoU; pfam01895 758678009432 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 758678009433 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 758678009434 23S rRNA interface [nucleotide binding]; other site 758678009435 L3 interface [polypeptide binding]; other site 758678009436 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 758678009437 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 758678009438 dimerization interface 3.5A [polypeptide binding]; other site 758678009439 active site 758678009440 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 758678009441 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 758678009442 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 758678009443 Walker A/P-loop; other site 758678009444 ATP binding site [chemical binding]; other site 758678009445 Q-loop/lid; other site 758678009446 ABC transporter signature motif; other site 758678009447 Walker B; other site 758678009448 D-loop; other site 758678009449 H-loop/switch region; other site 758678009450 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 758678009451 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 758678009452 Walker A/P-loop; other site 758678009453 ATP binding site [chemical binding]; other site 758678009454 Q-loop/lid; other site 758678009455 ABC transporter signature motif; other site 758678009456 Walker B; other site 758678009457 D-loop; other site 758678009458 H-loop/switch region; other site 758678009459 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 758678009460 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 758678009461 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 758678009462 alphaNTD homodimer interface [polypeptide binding]; other site 758678009463 alphaNTD - beta interaction site [polypeptide binding]; other site 758678009464 alphaNTD - beta' interaction site [polypeptide binding]; other site 758678009465 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 758678009466 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 758678009467 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 758678009468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678009469 RNA binding surface [nucleotide binding]; other site 758678009470 30S ribosomal protein S11; Validated; Region: PRK05309 758678009471 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 758678009472 30S ribosomal protein S13; Region: bact_S13; TIGR03631 758678009473 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 758678009474 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 758678009475 rRNA binding site [nucleotide binding]; other site 758678009476 predicted 30S ribosome binding site; other site 758678009477 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 758678009478 RNA binding site [nucleotide binding]; other site 758678009479 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 758678009480 active site 758678009481 adenylate kinase; Reviewed; Region: adk; PRK00279 758678009482 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 758678009483 AMP-binding site [chemical binding]; other site 758678009484 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 758678009485 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 758678009486 SecY translocase; Region: SecY; pfam00344 758678009487 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 758678009488 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 758678009489 23S rRNA binding site [nucleotide binding]; other site 758678009490 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 758678009491 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 758678009492 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 758678009493 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 758678009494 5S rRNA interface [nucleotide binding]; other site 758678009495 L27 interface [polypeptide binding]; other site 758678009496 23S rRNA interface [nucleotide binding]; other site 758678009497 L5 interface [polypeptide binding]; other site 758678009498 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 758678009499 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 758678009500 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 758678009501 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 758678009502 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 758678009503 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 758678009504 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 758678009505 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 758678009506 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 758678009507 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 758678009508 RNA binding site [nucleotide binding]; other site 758678009509 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 758678009510 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 758678009511 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 758678009512 23S rRNA interface [nucleotide binding]; other site 758678009513 putative translocon interaction site; other site 758678009514 signal recognition particle (SRP54) interaction site; other site 758678009515 L23 interface [polypeptide binding]; other site 758678009516 trigger factor interaction site; other site 758678009517 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 758678009518 23S rRNA interface [nucleotide binding]; other site 758678009519 5S rRNA interface [nucleotide binding]; other site 758678009520 putative antibiotic binding site [chemical binding]; other site 758678009521 L25 interface [polypeptide binding]; other site 758678009522 L27 interface [polypeptide binding]; other site 758678009523 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 758678009524 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 758678009525 G-X-X-G motif; other site 758678009526 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 758678009527 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 758678009528 putative translocon binding site; other site 758678009529 protein-rRNA interface [nucleotide binding]; other site 758678009530 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 758678009531 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 758678009532 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 758678009533 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 758678009534 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 758678009535 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 758678009536 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 758678009537 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 758678009538 elongation factor G; Reviewed; Region: PRK00007 758678009539 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 758678009540 G1 box; other site 758678009541 putative GEF interaction site [polypeptide binding]; other site 758678009542 GTP/Mg2+ binding site [chemical binding]; other site 758678009543 Switch I region; other site 758678009544 G2 box; other site 758678009545 G3 box; other site 758678009546 Switch II region; other site 758678009547 G4 box; other site 758678009548 G5 box; other site 758678009549 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 758678009550 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 758678009551 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 758678009552 30S ribosomal protein S7; Validated; Region: PRK05302 758678009553 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 758678009554 S17 interaction site [polypeptide binding]; other site 758678009555 S8 interaction site; other site 758678009556 16S rRNA interaction site [nucleotide binding]; other site 758678009557 streptomycin interaction site [chemical binding]; other site 758678009558 23S rRNA interaction site [nucleotide binding]; other site 758678009559 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 758678009560 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 758678009561 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 758678009562 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 758678009563 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 758678009564 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 758678009565 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 758678009566 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 758678009567 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 758678009568 G-loop; other site 758678009569 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 758678009570 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 758678009571 DNA binding site [nucleotide binding] 758678009572 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 758678009573 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 758678009574 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 758678009575 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 758678009576 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 758678009577 RPB1 interaction site [polypeptide binding]; other site 758678009578 RPB10 interaction site [polypeptide binding]; other site 758678009579 RPB11 interaction site [polypeptide binding]; other site 758678009580 RPB3 interaction site [polypeptide binding]; other site 758678009581 RPB12 interaction site [polypeptide binding]; other site 758678009582 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 758678009583 core dimer interface [polypeptide binding]; other site 758678009584 peripheral dimer interface [polypeptide binding]; other site 758678009585 L10 interface [polypeptide binding]; other site 758678009586 L11 interface [polypeptide binding]; other site 758678009587 putative EF-Tu interaction site [polypeptide binding]; other site 758678009588 putative EF-G interaction site [polypeptide binding]; other site 758678009589 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 758678009590 23S rRNA interface [nucleotide binding]; other site 758678009591 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 758678009592 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 758678009593 mRNA/rRNA interface [nucleotide binding]; other site 758678009594 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 758678009595 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 758678009596 23S rRNA interface [nucleotide binding]; other site 758678009597 L7/L12 interface [polypeptide binding]; other site 758678009598 putative thiostrepton binding site; other site 758678009599 L25 interface [polypeptide binding]; other site 758678009600 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 758678009601 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 758678009602 putative homodimer interface [polypeptide binding]; other site 758678009603 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 758678009604 heterodimer interface [polypeptide binding]; other site 758678009605 homodimer interface [polypeptide binding]; other site 758678009606 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 758678009607 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 758678009608 RNA polymerase factor sigma-70; Validated; Region: PRK08295 758678009609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678009610 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 758678009611 YacP-like NYN domain; Region: NYN_YacP; pfam05991 758678009612 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 758678009613 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 758678009614 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 758678009615 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 758678009616 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 758678009617 dimerization interface [polypeptide binding]; other site 758678009618 active site 758678009619 metal binding site [ion binding]; metal-binding site 758678009620 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 758678009621 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 758678009622 active site 758678009623 HIGH motif; other site 758678009624 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 758678009625 KMSKS motif; other site 758678009626 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 758678009627 tRNA binding surface [nucleotide binding]; other site 758678009628 anticodon binding site; other site 758678009629 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 758678009630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758678009631 tetramer interface [polypeptide binding]; other site 758678009632 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 758678009633 prolyl-tRNA synthetase; Provisional; Region: PRK09194 758678009634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 758678009635 motif 1; other site 758678009636 dimer interface [polypeptide binding]; other site 758678009637 active site 758678009638 motif 2; other site 758678009639 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 758678009640 putative deacylase active site [active] 758678009641 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 758678009642 anticodon binding site; other site 758678009643 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 758678009644 substrate binding site; other site 758678009645 dimer interface; other site 758678009646 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 758678009647 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 758678009648 putative active site [active] 758678009649 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 758678009650 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 758678009651 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 758678009652 DNA repair protein RadA; Provisional; Region: PRK11823 758678009653 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 758678009654 Walker A motif/ATP binding site; other site 758678009655 ATP binding site [chemical binding]; other site 758678009656 Walker B motif; other site 758678009657 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 758678009658 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 758678009659 Clp amino terminal domain; Region: Clp_N; pfam02861 758678009660 Clp amino terminal domain; Region: Clp_N; pfam02861 758678009661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009662 Walker A motif; other site 758678009663 ATP binding site [chemical binding]; other site 758678009664 Walker B motif; other site 758678009665 arginine finger; other site 758678009666 UvrB/uvrC motif; Region: UVR; pfam02151 758678009667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009668 Walker A motif; other site 758678009669 ATP binding site [chemical binding]; other site 758678009670 Walker B motif; other site 758678009671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 758678009672 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 758678009673 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 758678009674 ADP binding site [chemical binding]; other site 758678009675 phosphagen binding site; other site 758678009676 substrate specificity loop; other site 758678009677 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 758678009678 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 758678009679 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 758678009680 elongation factor G; Reviewed; Region: PRK12740 758678009681 G1 box; other site 758678009682 putative GEF interaction site [polypeptide binding]; other site 758678009683 GTP/Mg2+ binding site [chemical binding]; other site 758678009684 Switch I region; other site 758678009685 G2 box; other site 758678009686 G3 box; other site 758678009687 Switch II region; other site 758678009688 G4 box; other site 758678009689 G5 box; other site 758678009690 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 758678009691 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 758678009692 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 758678009693 glycyl-tRNA synthetase; Provisional; Region: PRK04173 758678009694 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 758678009695 motif 1; other site 758678009696 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 758678009697 active site 758678009698 motif 2; other site 758678009699 motif 3; other site 758678009700 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 758678009701 anticodon binding site; other site 758678009702 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 758678009703 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 758678009704 dimer interface [polypeptide binding]; other site 758678009705 putative anticodon binding site; other site 758678009706 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 758678009707 motif 1; other site 758678009708 active site 758678009709 motif 2; other site 758678009710 motif 3; other site 758678009711 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 758678009712 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 758678009713 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 758678009714 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 758678009715 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 758678009716 FMN binding site [chemical binding]; other site 758678009717 active site 758678009718 catalytic residues [active] 758678009719 substrate binding site [chemical binding]; other site 758678009720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758678009721 nucleotide binding site [chemical binding]; other site 758678009722 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 758678009723 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 758678009724 Potassium binding sites [ion binding]; other site 758678009725 Cesium cation binding sites [ion binding]; other site 758678009726 FtsH Extracellular; Region: FtsH_ext; pfam06480 758678009727 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 758678009728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009729 Walker A motif; other site 758678009730 ATP binding site [chemical binding]; other site 758678009731 Walker B motif; other site 758678009732 arginine finger; other site 758678009733 Peptidase family M41; Region: Peptidase_M41; pfam01434 758678009734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678009735 active site 758678009736 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 758678009737 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 758678009738 Ligand Binding Site [chemical binding]; other site 758678009739 TilS substrate C-terminal domain; Region: TilS_C; smart00977 758678009740 stage II sporulation protein E; Region: spore_II_E; TIGR02865 758678009741 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 758678009742 hypothetical protein; Provisional; Region: PRK05807 758678009743 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 758678009744 RNA binding site [nucleotide binding]; other site 758678009745 Septum formation initiator; Region: DivIC; pfam04977 758678009746 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 758678009747 sporulation protein YabP; Region: spore_yabP; TIGR02892 758678009748 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758678009749 RNA binding surface [nucleotide binding]; other site 758678009750 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 758678009751 IHF dimer interface [polypeptide binding]; other site 758678009752 IHF - DNA interface [nucleotide binding]; other site 758678009753 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 758678009754 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 758678009755 putative SAM binding site [chemical binding]; other site 758678009756 putative homodimer interface [polypeptide binding]; other site 758678009757 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 758678009758 homodimer interface [polypeptide binding]; other site 758678009759 metal binding site [ion binding]; metal-binding site 758678009760 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 758678009761 homodimer interface [polypeptide binding]; other site 758678009762 active site 758678009763 putative chemical substrate binding site [chemical binding]; other site 758678009764 metal binding site [ion binding]; metal-binding site 758678009765 stage V sporulation protein B; Region: spore_V_B; TIGR02900 758678009766 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 758678009767 stage V sporulation protein T; Region: spore_V_T; TIGR02851 758678009768 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 758678009769 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 758678009770 SurA N-terminal domain; Region: SurA_N_3; cl07813 758678009771 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758678009772 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 758678009773 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 758678009774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758678009775 ATP binding site [chemical binding]; other site 758678009776 putative Mg++ binding site [ion binding]; other site 758678009777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758678009778 nucleotide binding region [chemical binding]; other site 758678009779 ATP-binding site [chemical binding]; other site 758678009780 TRCF domain; Region: TRCF; pfam03461 758678009781 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 758678009782 putative active site [active] 758678009783 catalytic residue [active] 758678009784 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 758678009785 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758678009786 protein binding site [polypeptide binding]; other site 758678009787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758678009788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758678009789 dimerization interface [polypeptide binding]; other site 758678009790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758678009791 dimer interface [polypeptide binding]; other site 758678009792 phosphorylation site [posttranslational modification] 758678009793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758678009794 ATP binding site [chemical binding]; other site 758678009795 Mg2+ binding site [ion binding]; other site 758678009796 G-X-G motif; other site 758678009797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758678009798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758678009799 active site 758678009800 phosphorylation site [posttranslational modification] 758678009801 intermolecular recognition site; other site 758678009802 dimerization interface [polypeptide binding]; other site 758678009803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758678009804 DNA binding site [nucleotide binding] 758678009805 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 758678009806 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 758678009807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678009808 active site 758678009809 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 758678009810 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 758678009811 Substrate binding site; other site 758678009812 Mg++ binding site; other site 758678009813 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 758678009814 active site 758678009815 substrate binding site [chemical binding]; other site 758678009816 CoA binding site [chemical binding]; other site 758678009817 regulatory protein SpoVG; Reviewed; Region: PRK13259 758678009818 pur operon repressor; Provisional; Region: PRK09213 758678009819 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 758678009820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758678009821 active site 758678009822 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 758678009823 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758678009824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758678009825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758678009826 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 758678009827 4Fe-4S binding domain; Region: Fer4; pfam00037 758678009828 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 758678009829 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 758678009830 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758678009831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758678009832 motif II; other site 758678009833 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 758678009834 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 758678009835 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 758678009836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678009837 FeS/SAM binding site; other site 758678009838 Uncharacterized membrane protein [Function unknown]; Region: COG3949 758678009839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678009840 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 758678009841 FeS/SAM binding site; other site 758678009842 Heme NO binding; Region: HNOB; pfam07700 758678009843 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758678009844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758678009845 dimer interface [polypeptide binding]; other site 758678009846 putative CheW interface [polypeptide binding]; other site 758678009847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678009848 non-specific DNA binding site [nucleotide binding]; other site 758678009849 salt bridge; other site 758678009850 sequence-specific DNA binding site [nucleotide binding]; other site 758678009851 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 758678009852 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 758678009853 active site 758678009854 glutamate racemase; Provisional; Region: PRK00865 758678009855 glutamine synthetase, type I; Region: GlnA; TIGR00653 758678009856 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 758678009857 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 758678009858 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 758678009859 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 758678009860 hinge; other site 758678009861 active site 758678009862 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 758678009863 Sporulation and spore germination; Region: Germane; pfam10646 758678009864 hypothetical protein; Provisional; Region: PRK05590 758678009865 SEC-C motif; Region: SEC-C; pfam02810 758678009866 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 758678009867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758678009868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758678009869 putative substrate translocation pore; other site 758678009870 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758678009871 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758678009872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758678009873 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 758678009874 DNA-binding interface [nucleotide binding]; DNA binding site 758678009875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678009876 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758678009877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758678009878 methionine aminopeptidase; Provisional; Region: PRK12318 758678009879 SEC-C motif; Region: SEC-C; pfam02810 758678009880 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 758678009881 active site 758678009882 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 758678009883 putative FMN binding site [chemical binding]; other site 758678009884 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678009885 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678009886 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 758678009887 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 758678009888 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 758678009889 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 758678009890 Pyruvate formate lyase; Region: PFL; pfam02901 758678009891 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 758678009892 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 758678009893 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 758678009894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758678009895 FeS/SAM binding site; other site 758678009896 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 758678009897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 758678009898 FeS/SAM binding site; other site 758678009899 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 758678009900 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 758678009901 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 758678009902 G1 box; other site 758678009903 GTP/Mg2+ binding site [chemical binding]; other site 758678009904 Switch I region; other site 758678009905 G2 box; other site 758678009906 Switch II region; other site 758678009907 G3 box; other site 758678009908 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 758678009909 Na binding site [ion binding]; other site 758678009910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758678009911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758678009912 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 758678009913 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 758678009914 active site 758678009915 PHP-associated; Region: PHP_C; pfam13263 758678009916 dUTPase; Region: dUTPase_2; pfam08761 758678009917 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 758678009918 active site 758678009919 homodimer interface [polypeptide binding]; other site 758678009920 metal binding site [ion binding]; metal-binding site 758678009921 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758678009922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758678009923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678009924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758678009925 dimerization interface [polypeptide binding]; other site 758678009926 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 758678009927 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 758678009928 active site 758678009929 catalytic residues [active] 758678009930 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 758678009931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758678009932 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 758678009933 putative dimerization interface [polypeptide binding]; other site 758678009934 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 758678009935 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 758678009936 putative ligand binding site [chemical binding]; other site 758678009937 NAD binding site [chemical binding]; other site 758678009938 catalytic site [active] 758678009939 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 758678009940 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 758678009941 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 758678009942 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 758678009943 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 758678009944 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 758678009945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758678009946 carboxyltransferase (CT) interaction site; other site 758678009947 biotinylation site [posttranslational modification]; other site 758678009948 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 758678009949 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758678009950 dimer interface [polypeptide binding]; other site 758678009951 active site 758678009952 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758678009953 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 758678009954 NAD(P) binding site [chemical binding]; other site 758678009955 homotetramer interface [polypeptide binding]; other site 758678009956 homodimer interface [polypeptide binding]; other site 758678009957 active site 758678009958 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 758678009959 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 758678009960 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 758678009961 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 758678009962 FMN binding site [chemical binding]; other site 758678009963 substrate binding site [chemical binding]; other site 758678009964 putative catalytic residue [active] 758678009965 acyl carrier protein; Provisional; Region: acpP; PRK00982 758678009966 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 758678009967 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 758678009968 dimer interface [polypeptide binding]; other site 758678009969 active site 758678009970 CoA binding pocket [chemical binding]; other site 758678009971 MarR family; Region: MarR_2; pfam12802 758678009972 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 758678009973 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 758678009974 FMN binding site [chemical binding]; other site 758678009975 substrate binding site [chemical binding]; other site 758678009976 putative catalytic residue [active] 758678009977 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758678009978 Peptidase family M23; Region: Peptidase_M23; pfam01551 758678009979 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 758678009980 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 758678009981 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 758678009982 DNA replication protein DnaC; Validated; Region: PRK06835 758678009983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678009984 Walker A motif; other site 758678009985 ATP binding site [chemical binding]; other site 758678009986 PEP synthetase regulatory protein; Provisional; Region: PRK05339 758678009987 CoA binding domain; Region: CoA_binding_2; pfam13380 758678009988 flavoprotein, HI0933 family; Region: TIGR00275 758678009989 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 758678009990 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758678009991 active site 758678009992 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758678009993 active site 758678009994 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 758678009995 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 758678009996 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 758678009997 GDP-binding site [chemical binding]; other site 758678009998 ACT binding site; other site 758678009999 IMP binding site; other site 758678010000 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 758678010001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758678010002 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 758678010003 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 758678010004 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 758678010005 active site 758678010006 substrate binding site [chemical binding]; other site 758678010007 metal binding site [ion binding]; metal-binding site 758678010008 replicative DNA helicase; Provisional; Region: PRK05595 758678010009 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 758678010010 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 758678010011 Walker A motif; other site 758678010012 ATP binding site [chemical binding]; other site 758678010013 Walker B motif; other site 758678010014 DNA binding loops [nucleotide binding] 758678010015 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 758678010016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758678010017 Walker A motif; other site 758678010018 ATP binding site [chemical binding]; other site 758678010019 Walker B motif; other site 758678010020 arginine finger; other site 758678010021 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 758678010022 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 758678010023 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 758678010024 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 758678010025 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 758678010026 MazG-like family; Region: MazG-like; pfam12643 758678010027 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 758678010028 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 758678010029 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 758678010030 dimer interface [polypeptide binding]; other site 758678010031 ssDNA binding site [nucleotide binding]; other site 758678010032 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758678010033 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 758678010034 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 758678010035 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 758678010036 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 758678010037 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758678010038 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758678010039 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 758678010040 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 758678010041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758678010042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758678010043 catalytic residue [active] 758678010044 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 758678010045 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 758678010046 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 758678010047 ParB-like nuclease domain; Region: ParB; smart00470 758678010048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 758678010049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758678010050 P-loop; other site 758678010051 Magnesium ion binding site [ion binding]; other site 758678010052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758678010053 Magnesium ion binding site [ion binding]; other site 758678010054 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 758678010055 ParB-like nuclease domain; Region: ParBc; pfam02195 758678010056 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 758678010057 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 758678010058 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 758678010059 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 758678010060 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 758678010061 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 758678010062 potential frameshift: common BLAST hit: gi|153937917|ref|YP_001392999.1| tRNA modification GTPase TrmE 758678010063 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 758678010064 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 758678010065 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 758678010066 trmE is a tRNA modification GTPase; Region: trmE; cd04164 758678010067 G1 box; other site 758678010068 Switch I region; other site 758678010069 G2 box; other site 758678010070 Switch II region; other site 758678010071 G3 box; other site 758678010072 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 758678010073 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 758678010074 G-X-X-G motif; other site 758678010075 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 758678010076 RxxxH motif; other site 758678010077 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 758678010078 Haemolytic domain; Region: Haemolytic; pfam01809 758678010079 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 758678010080 putative active site [active] 758678010081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758678010082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758678010083 non-specific DNA binding site [nucleotide binding]; other site 758678010084 salt bridge; other site 758678010085 sequence-specific DNA binding site [nucleotide binding]; other site 758678010086 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758678010087 active site 758678010088 DNA binding site [nucleotide binding] 758678010089 Int/Topo IB signature motif; other site 758678010090 CAAX protease self-immunity; Region: Abi; pfam02517 758678010091 Initiator Replication protein; Region: Rep_3; pfam01051 758678010092 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 758678010093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 758678010094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758678010095 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 758678010096 generic binding surface I; other site 758678010097 generic binding surface II; other site 758678010098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758678010099 catalytic core [active] 758678010100 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 758678010101 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 758678010102 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 758678010103 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 758678010104 tyrosine aminotransferase; Provisional; Region: PTZ00433 758678010105 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 758678010106 HlyD family secretion protein; Region: HlyD_3; pfam13437 758678010107 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 758678010108 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 758678010109 putative active site [active] 758678010110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758678010111 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 758678010112 Walker A/P-loop; other site 758678010113 ATP binding site [chemical binding]; other site 758678010114 Q-loop/lid; other site 758678010115 ABC transporter signature motif; other site 758678010116 Walker B; other site 758678010117 D-loop; other site 758678010118 H-loop/switch region; other site