-- dump date 20140619_043715 -- class Genbank::misc_feature -- table misc_feature_note -- id note 941968000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 941968000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 941968000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968000004 Walker A motif; other site 941968000005 ATP binding site [chemical binding]; other site 941968000006 Walker B motif; other site 941968000007 arginine finger; other site 941968000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 941968000009 DnaA box-binding interface [nucleotide binding]; other site 941968000010 1 probable transmembrane helix predicted for cbot00001 by TMHMM2.0 at aa 42-64 941968000014 1 probable transmembrane helix predicted for cbot00002 by TMHMM2.0 at aa 51-73 941968000016 DNA polymerase III subunit beta; Validated; Region: PRK05643 941968000017 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 941968000018 putative DNA binding surface [nucleotide binding]; other site 941968000019 dimer interface [polypeptide binding]; other site 941968000020 beta-clamp/clamp loader binding surface; other site 941968000021 beta-clamp/translesion DNA polymerase binding surface; other site 941968000026 S4 domain; Region: S4_2; pfam13275 941968000028 recombination protein F; Reviewed; Region: recF; PRK00064 941968000029 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 941968000030 Walker A/P-loop; other site 941968000031 ATP binding site [chemical binding]; other site 941968000032 Q-loop/lid; other site 941968000033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968000034 ABC transporter signature motif; other site 941968000035 Walker B; other site 941968000036 D-loop; other site 941968000037 H-loop/switch region; other site 941968000040 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 941968000041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968000042 Mg2+ binding site [ion binding]; other site 941968000043 G-X-G motif; other site 941968000044 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941968000045 anchoring element; other site 941968000046 dimer interface [polypeptide binding]; other site 941968000047 ATP binding site [chemical binding]; other site 941968000048 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 941968000049 active site 941968000050 putative metal-binding site [ion binding]; other site 941968000051 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941968000060 DNA gyrase subunit A; Validated; Region: PRK05560 941968000061 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941968000062 CAP-like domain; other site 941968000063 active site 941968000064 primary dimer interface [polypeptide binding]; other site 941968000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968000084 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 941968000085 HTH domain; Region: HTH_11; pfam08279 941968000086 3H domain; Region: 3H; pfam02829 941968000089 Uncharacterized conserved protein [Function unknown]; Region: COG2006 941968000090 Domain of unknown function (DUF362); Region: DUF362; pfam04015 941968000091 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968000092 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 941968000097 hypothetical protein; Validated; Region: PRK00068 941968000098 Uncharacterized conserved protein [Function unknown]; Region: COG1615 941968000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941968000102 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941968000106 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941968000107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941968000108 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941968000112 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 941968000114 seryl-tRNA synthetase; Provisional; Region: PRK05431 941968000115 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 941968000116 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 941968000117 dimer interface [polypeptide binding]; other site 941968000118 active site 941968000119 motif 1; other site 941968000120 motif 2; other site 941968000121 motif 3; other site 941968000124 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 941968000126 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 941968000127 ABC1 family; Region: ABC1; cl17513 941968000129 Uncharacterized conserved protein [Function unknown]; Region: COG3937 941968000130 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 941968000131 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941968000132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968000133 Walker A motif; other site 941968000134 ATP binding site [chemical binding]; other site 941968000135 Walker B motif; other site 941968000136 arginine finger; other site 941968000140 methionine gamma-lyase; Provisional; Region: PRK06234 941968000141 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941968000142 homodimer interface [polypeptide binding]; other site 941968000143 substrate-cofactor binding pocket; other site 941968000144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968000145 catalytic residue [active] 941968000148 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941968000149 nucleoside/Zn binding site; other site 941968000150 dimer interface [polypeptide binding]; other site 941968000151 catalytic motif [active] 941968000153 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 941968000154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968000155 Walker A motif; other site 941968000156 ATP binding site [chemical binding]; other site 941968000157 Walker B motif; other site 941968000158 arginine finger; other site 941968000159 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 941968000165 hypothetical protein; Validated; Region: PRK00153 941968000167 recombination protein RecR; Reviewed; Region: recR; PRK00076 941968000168 RecR protein; Region: RecR; pfam02132 941968000169 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 941968000170 putative active site [active] 941968000171 putative metal-binding site [ion binding]; other site 941968000172 tetramer interface [polypeptide binding]; other site 941968000174 1 probable transmembrane helix predicted for cbot00025 by TMHMM2.0 at aa 13-35 941968000178 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 941968000180 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 941968000183 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 941968000186 1 probable transmembrane helix predicted for cbot00028 by TMHMM2.0 at aa 36-53 941968000187 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 941968000188 putative NADH binding site [chemical binding]; other site 941968000189 putative active site [active] 941968000190 nudix motif; other site 941968000191 putative metal binding site [ion binding]; other site 941968000193 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941968000196 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968000197 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968000198 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 941968000200 1 probable transmembrane helix predicted for cbot00031 by TMHMM2.0 at aa 15-37 941968000201 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 941968000202 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 941968000203 putative ATP binding site [chemical binding]; other site 941968000204 putative substrate interface [chemical binding]; other site 941968000206 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 941968000208 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968000209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941968000211 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 941968000212 active site 941968000213 Fe-S cluster binding site [ion binding]; other site 941968000215 RNA polymerase factor sigma-70; Validated; Region: PRK06811 941968000216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968000217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968000218 DNA binding residues [nucleotide binding] 941968000219 1 probable transmembrane helix predicted for cbot00037 by TMHMM2.0 at aa 7-24 941968000221 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 941968000222 DltD C-terminal region; Region: DltD_C; pfam04914 941968000224 SurA N-terminal domain; Region: SurA_N_3; cl07813 941968000225 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941968000226 1 probable transmembrane helix predicted for cbot00042 by TMHMM2.0 at aa 31-53 941968000228 NAD-dependent deacetylase; Provisional; Region: PRK00481 941968000229 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 941968000231 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 941968000232 dimer interface [polypeptide binding]; other site 941968000233 catalytic triad [active] 941968000237 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941968000238 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 941968000239 Cl binding site [ion binding]; other site 941968000240 oligomer interface [polypeptide binding]; other site 941968000243 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941968000244 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 941968000245 metal binding site [ion binding]; metal-binding site 941968000246 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 941968000248 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941968000249 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 941968000250 homodimer interface [polypeptide binding]; other site 941968000251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968000252 catalytic residue [active] 941968000253 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941968000257 thymidylate kinase; Provisional; Region: PRK13975; cl17243 941968000259 1 probable transmembrane helix predicted for cbot00051 by TMHMM2.0 at aa 5-27 941968000261 Protein of unknown function (DUF970); Region: DUF970; pfam06153 941968000264 1 probable transmembrane helix predicted for cbot00052 by TMHMM2.0 at aa 10-32 941968000265 DNA polymerase III subunit delta'; Validated; Region: PRK05564 941968000266 DNA polymerase III subunit delta'; Validated; Region: PRK08485 941968000269 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 941968000271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968000272 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941968000276 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 941968000277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968000278 S-adenosylmethionine binding site [chemical binding]; other site 941968000281 Predicted methyltransferases [General function prediction only]; Region: COG0313 941968000282 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 941968000283 putative SAM binding site [chemical binding]; other site 941968000284 putative homodimer interface [polypeptide binding]; other site 941968000286 1 probable transmembrane helix predicted for cbot00057 by TMHMM2.0 at aa 43-62 941968000287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 941968000288 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941968000289 NlpC/P60 family; Region: NLPC_P60; pfam00877 941968000293 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 941968000294 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 941968000296 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 941968000298 arginine deiminase; Provisional; Region: PRK01388 941968000299 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 941968000302 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 941968000303 homotrimer interaction site [polypeptide binding]; other site 941968000304 zinc binding site [ion binding]; other site 941968000305 CDP-binding sites; other site 941968000307 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941968000308 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 941968000309 putative active site [active] 941968000310 putative metal binding site [ion binding]; other site 941968000314 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 941968000317 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 941968000319 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968000320 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 941968000323 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 941968000324 Fe-S cluster binding site [ion binding]; other site 941968000325 active site 941968000328 1 probable transmembrane helix predicted for cbot00068 by TMHMM2.0 at aa 35-57 941968000329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968000330 MarR family; Region: MarR_2; cl17246 941968000334 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 941968000335 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 941968000336 active site 941968000337 HIGH motif; other site 941968000338 KMSKS motif; other site 941968000339 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 941968000340 anticodon binding site; other site 941968000341 tRNA binding surface [nucleotide binding]; other site 941968000342 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 941968000343 dimer interface [polypeptide binding]; other site 941968000344 putative tRNA-binding site [nucleotide binding]; other site 941968000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 941968000352 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941968000353 active site 941968000356 Domain of unknown function (DUF348); Region: DUF348; pfam03990 941968000357 Domain of unknown function (DUF348); Region: DUF348; pfam03990 941968000358 G5 domain; Region: G5; pfam07501 941968000359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941968000367 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 941968000368 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 941968000369 putative active site [active] 941968000370 putative metal binding site [ion binding]; other site 941968000371 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 941968000377 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 941968000378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968000379 S-adenosylmethionine binding site [chemical binding]; other site 941968000383 1 probable transmembrane helix predicted for cbot00075 by TMHMM2.0 at aa 34-53 941968000387 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 941968000388 HlyD family secretion protein; Region: HlyD_3; pfam13437 941968000390 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968000391 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968000392 Walker A/P-loop; other site 941968000393 ATP binding site [chemical binding]; other site 941968000394 Q-loop/lid; other site 941968000395 ABC transporter signature motif; other site 941968000396 Walker B; other site 941968000397 D-loop; other site 941968000398 H-loop/switch region; other site 941968000401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968000402 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968000403 FtsX-like permease family; Region: FtsX; pfam02687 941968000405 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 941968000406 1 probable transmembrane helix predicted for cbot00082 by TMHMM2.0 at aa 31-53 941968000408 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968000409 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 941968000410 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941968000411 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968000412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968000413 metal binding site [ion binding]; metal-binding site 941968000414 active site 941968000415 I-site; other site 941968000419 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941968000420 MgtC family; Region: MgtC; pfam02308 941968000422 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 941968000423 ATP cone domain; Region: ATP-cone; pfam03477 941968000424 Class III ribonucleotide reductase; Region: RNR_III; cd01675 941968000425 effector binding site; other site 941968000426 active site 941968000427 Zn binding site [ion binding]; other site 941968000428 glycine loop; other site 941968000433 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 941968000434 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 941968000436 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 941968000438 Predicted transcriptional regulators [Transcription]; Region: COG1695 941968000439 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 941968000441 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 941968000442 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 941968000443 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 941968000444 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941968000445 HIGH motif; other site 941968000446 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941968000447 active site 941968000448 KMSKS motif; other site 941968000449 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 941968000450 tRNA binding surface [nucleotide binding]; other site 941968000451 anticodon binding site; other site 941968000457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941968000458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941968000459 DNA binding site [nucleotide binding] 941968000460 domain linker motif; other site 941968000461 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941968000466 AAA domain; Region: AAA_11; pfam13086 941968000467 Part of AAA domain; Region: AAA_19; pfam13245 941968000468 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 941968000469 AAA domain; Region: AAA_12; pfam13087 941968000470 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 941968000471 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 941968000472 Substrate binding site; other site 941968000473 Cupin domain; Region: Cupin_2; cl17218 941968000477 hypothetical protein; Provisional; Region: PRK04194 941968000481 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 941968000482 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 941968000483 Ligand Binding Site [chemical binding]; other site 941968000485 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 941968000486 AIR carboxylase; Region: AIRC; smart01001 941968000489 1 probable transmembrane helix predicted for cbot00098 by TMHMM2.0 at aa 38-60 941968000491 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 941968000492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968000493 FeS/SAM binding site; other site 941968000498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941968000502 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941968000503 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 941968000505 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 941968000506 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941968000507 substrate binding site [chemical binding]; other site 941968000510 1 probable transmembrane helix predicted for cbot00104 by TMHMM2.0 at aa 12-34 941968000511 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 941968000512 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 941968000513 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941968000514 substrate binding site [chemical binding]; other site 941968000515 1 probable transmembrane helix predicted for cbot00106 by TMHMM2.0 at aa 15-37 941968000517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968000518 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 941968000520 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 941968000521 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941968000522 active site 941968000523 ATP binding site [chemical binding]; other site 941968000524 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941968000525 substrate binding site [chemical binding]; other site 941968000528 YabG peptidase U57; Region: Peptidase_U57; pfam05582 941968000531 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 941968000533 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 941968000534 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 941968000535 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 941968000536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968000540 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 941968000541 proposed catalytic triad [active] 941968000542 active site nucleophile [active] 941968000546 cyanophycin synthetase; Provisional; Region: PRK14016 941968000547 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941968000548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968000549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941968000557 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 941968000558 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941968000562 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 941968000564 Spore germination protein; Region: Spore_permease; cl17796 941968000567 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 941968000568 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 941968000572 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 941968000575 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 941968000576 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 941968000577 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968000580 1 probable transmembrane helix predicted for cbot00120 by TMHMM2.0 at aa 52-74 941968000581 germination protein YpeB; Region: spore_YpeB; TIGR02889 941968000584 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 941968000585 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 941968000586 Ligand Binding Site [chemical binding]; other site 941968000587 Domain of unknown function (DUF814); Region: DUF814; pfam05670 941968000590 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 941968000593 CTP synthetase; Validated; Region: pyrG; PRK05380 941968000594 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 941968000595 Catalytic site [active] 941968000596 active site 941968000597 UTP binding site [chemical binding]; other site 941968000598 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 941968000599 active site 941968000600 putative oxyanion hole; other site 941968000601 catalytic triad [active] 941968000606 1 probable transmembrane helix predicted for cbot00126 by TMHMM2.0 at aa 5-27 941968000607 transcription termination factor Rho; Provisional; Region: rho; PRK09376 941968000608 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 941968000609 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 941968000610 RNA binding site [nucleotide binding]; other site 941968000611 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941968000612 Walker A motif; other site 941968000613 ATP binding site [chemical binding]; other site 941968000614 Walker B motif; other site 941968000621 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 941968000623 thymidine kinase; Provisional; Region: PRK04296 941968000626 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 941968000628 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 941968000629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968000631 1 probable transmembrane helix predicted for cbot00131 by TMHMM2.0 at aa 33-52 941968000633 peptide chain release factor 1; Validated; Region: prfA; PRK00591 941968000634 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941968000635 RF-1 domain; Region: RF-1; pfam00472 941968000640 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 941968000642 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 941968000643 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 941968000647 Low molecular weight phosphatase family; Region: LMWPc; cd00115 941968000648 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 941968000649 active site 941968000652 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 941968000655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968000656 active site 941968000658 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 941968000659 active site 941968000660 Zn binding site [ion binding]; other site 941968000662 1 probable transmembrane helix predicted for cbot00139 by TMHMM2.0 at aa 32-54 941968000663 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 941968000664 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 941968000665 Mg++ binding site [ion binding]; other site 941968000666 putative catalytic motif [active] 941968000667 substrate binding site [chemical binding]; other site 941968000671 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 941968000672 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 941968000673 active site 941968000674 homodimer interface [polypeptide binding]; other site 941968000679 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 941968000681 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 941968000684 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 941968000685 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 941968000687 1 probable transmembrane helix predicted for cbot00145 by TMHMM2.0 at aa 5-27 941968000689 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 941968000690 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 941968000693 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 941968000694 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941968000695 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 941968000696 beta subunit interaction interface [polypeptide binding]; other site 941968000697 Walker A motif; other site 941968000698 ATP binding site [chemical binding]; other site 941968000699 Walker B motif; other site 941968000700 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941968000706 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 941968000707 core domain interface [polypeptide binding]; other site 941968000708 delta subunit interface [polypeptide binding]; other site 941968000709 epsilon subunit interface [polypeptide binding]; other site 941968000711 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 941968000712 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941968000713 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 941968000714 alpha subunit interaction interface [polypeptide binding]; other site 941968000715 Walker A motif; other site 941968000716 ATP binding site [chemical binding]; other site 941968000717 Walker B motif; other site 941968000718 inhibitor binding site; inhibition site 941968000719 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941968000724 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 941968000725 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 941968000726 gamma subunit interface [polypeptide binding]; other site 941968000727 epsilon subunit interface [polypeptide binding]; other site 941968000728 LBP interface [polypeptide binding]; other site 941968000732 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 941968000735 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 941968000736 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941968000737 hinge; other site 941968000738 active site 941968000741 stage II sporulation protein D; Region: spore_II_D; TIGR02870 941968000742 Stage II sporulation protein; Region: SpoIID; pfam08486 941968000745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941968000746 Peptidase family M23; Region: Peptidase_M23; pfam01551 941968000750 Stage III sporulation protein D; Region: SpoIIID; pfam12116 941968000752 rod shape-determining protein Mbl; Provisional; Region: PRK13928 941968000753 MreB and similar proteins; Region: MreB_like; cd10225 941968000754 nucleotide binding site [chemical binding]; other site 941968000755 Mg binding site [ion binding]; other site 941968000756 putative protofilament interaction site [polypeptide binding]; other site 941968000757 RodZ interaction site [polypeptide binding]; other site 941968000761 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 941968000763 1 probable transmembrane helix predicted for cbot00157 by TMHMM2.0 at aa 28-50 941968000764 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 941968000765 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 941968000766 Ligand Binding Site [chemical binding]; other site 941968000769 S-adenosylmethionine synthetase; Validated; Region: PRK05250 941968000770 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 941968000771 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 941968000772 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 941968000774 1 probable transmembrane helix predicted for cbot00159 by TMHMM2.0 at aa 35-54 941968000777 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 941968000778 AAA domain; Region: AAA_30; pfam13604 941968000779 Family description; Region: UvrD_C_2; pfam13538 941968000787 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 941968000789 1 probable transmembrane helix predicted for cbot00161 by TMHMM2.0 at aa 12-31 941968000790 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 941968000791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968000792 active site 941968000793 1 probable transmembrane helix predicted for cbot00162 by TMHMM2.0 at aa 10-32 941968000795 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 941968000796 30S subunit binding site; other site 941968000798 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 941968000799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941968000800 ATP binding site [chemical binding]; other site 941968000801 putative Mg++ binding site [ion binding]; other site 941968000802 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 941968000803 SEC-C motif; Region: SEC-C; pfam02810 941968000813 peptide chain release factor 2; Provisional; Region: PRK05589 941968000814 PCRF domain; Region: PCRF; pfam03462 941968000815 RF-1 domain; Region: RF-1; pfam00472 941968000819 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941968000820 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 941968000821 Peptidase family M28; Region: Peptidase_M28; pfam04389 941968000822 metal binding site [ion binding]; metal-binding site 941968000825 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 941968000826 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 941968000827 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 941968000828 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 941968000829 RNA binding site [nucleotide binding]; other site 941968000835 Predicted membrane protein [Function unknown]; Region: COG3601 941968000836 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 941968000839 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 941968000841 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 941968000842 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941968000843 putative active site [active] 941968000844 putative metal binding site [ion binding]; other site 941968000846 1 probable transmembrane helix predicted for cbot00171 by TMHMM2.0 at aa 12-34 941968000847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968000848 dimerization interface [polypeptide binding]; other site 941968000849 putative DNA binding site [nucleotide binding]; other site 941968000850 putative Zn2+ binding site [ion binding]; other site 941968000853 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 941968000854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968000855 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941968000856 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 941968000857 active site residue [active] 941968000858 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 941968000859 CPxP motif; other site 941968000860 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 941968000871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 941968000872 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 941968000874 1 probable transmembrane helix predicted for cbot00174 by TMHMM2.0 at aa 10-32 941968000875 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941968000876 synthetase active site [active] 941968000877 NTP binding site [chemical binding]; other site 941968000878 metal binding site [ion binding]; metal-binding site 941968000880 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 941968000881 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 941968000882 HIGH motif; other site 941968000883 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941968000884 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941968000885 active site 941968000886 KMSKS motif; other site 941968000887 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 941968000888 tRNA binding surface [nucleotide binding]; other site 941968000895 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941968000896 active site residue [active] 941968000900 1 probable transmembrane helix predicted for cbot00178 by TMHMM2.0 at aa 9-28 941968000901 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941968000902 HSP70 interaction site [polypeptide binding]; other site 941968000906 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 941968000907 putative active site [active] 941968000908 putative triphosphate binding site [ion binding]; other site 941968000909 dimer interface [polypeptide binding]; other site 941968000911 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 941968000913 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 941968000914 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 941968000915 intersubunit interface [polypeptide binding]; other site 941968000916 active site 941968000917 zinc binding site [ion binding]; other site 941968000918 Na+ binding site [ion binding]; other site 941968000921 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 941968000922 Predicted membrane protein [Function unknown]; Region: COG2323 941968000924 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 941968000925 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 941968000926 active site 941968000930 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 941968000931 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 941968000933 FOG: CBS domain [General function prediction only]; Region: COG0517 941968000934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 941968000937 1 probable transmembrane helix predicted for cbot00190 by TMHMM2.0 at aa 7-29 941968000941 putative lipid kinase; Reviewed; Region: PRK13059 941968000942 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 941968000947 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 941968000948 hypothetical protein; Provisional; Region: PRK00955 941968000949 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 941968000955 PRC-barrel domain; Region: PRC; pfam05239 941968000956 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 941968000957 MgtE intracellular N domain; Region: MgtE_N; smart00924 941968000958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 941968000966 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 941968000967 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941968000968 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941968000973 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941968000974 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941968000975 dimer interface [polypeptide binding]; other site 941968000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968000977 catalytic residue [active] 941968000981 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 941968000982 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 941968000983 trimer interface [polypeptide binding]; other site 941968000984 active site 941968000985 substrate binding site [chemical binding]; other site 941968000986 CoA binding site [chemical binding]; other site 941968000988 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 941968000989 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 941968000991 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941968000992 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941968000993 putative acyl-acceptor binding pocket; other site 941968000996 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 941968000997 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941968000998 minor groove reading motif; other site 941968000999 helix-hairpin-helix signature motif; other site 941968001000 substrate binding pocket [chemical binding]; other site 941968001001 active site 941968001002 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941968001009 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941968001010 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 941968001011 putative NAD(P) binding site [chemical binding]; other site 941968001018 competence damage-inducible protein A; Provisional; Region: PRK00549 941968001019 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 941968001020 putative MPT binding site; other site 941968001021 Competence-damaged protein; Region: CinA; pfam02464 941968001025 1 probable transmembrane helix predicted for cbot00202 by TMHMM2.0 at aa 30-52 941968001026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 941968001027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941968001030 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 941968001031 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 941968001032 putative oligomer interface [polypeptide binding]; other site 941968001033 putative active site [active] 941968001034 metal binding site [ion binding]; metal-binding site 941968001037 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941968001038 VanW like protein; Region: VanW; pfam04294 941968001042 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941968001043 VanW like protein; Region: VanW; pfam04294 941968001044 G5 domain; Region: G5; pfam07501 941968001049 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 941968001050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968001051 FeS/SAM binding site; other site 941968001053 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 941968001056 1 probable transmembrane helix predicted for cbot00208 by TMHMM2.0 at aa 13-35 941968001057 EDD domain protein, DegV family; Region: DegV; TIGR00762 941968001058 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941968001061 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941968001062 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 941968001063 ligand binding site [chemical binding]; other site 941968001067 1 probable transmembrane helix predicted for cbot00210 by TMHMM2.0 at aa 15-37 941968001069 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 941968001070 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941968001071 Walker A/P-loop; other site 941968001072 ATP binding site [chemical binding]; other site 941968001073 Q-loop/lid; other site 941968001074 ABC transporter signature motif; other site 941968001075 Walker B; other site 941968001076 D-loop; other site 941968001077 H-loop/switch region; other site 941968001078 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941968001084 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941968001085 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941968001086 TM-ABC transporter signature motif; other site 941968001089 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941968001090 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941968001091 TM-ABC transporter signature motif; other site 941968001094 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941968001095 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 941968001096 NodB motif; other site 941968001097 active site 941968001098 catalytic site [active] 941968001099 Zn binding site [ion binding]; other site 941968001102 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 941968001103 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 941968001104 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 941968001105 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 941968001110 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941968001111 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941968001114 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 941968001115 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941968001116 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941968001122 Phosphoglycerate kinase; Region: PGK; pfam00162 941968001123 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 941968001124 substrate binding site [chemical binding]; other site 941968001125 hinge regions; other site 941968001126 ADP binding site [chemical binding]; other site 941968001127 catalytic site [active] 941968001132 triosephosphate isomerase; Provisional; Region: PRK14567 941968001133 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 941968001134 substrate binding site [chemical binding]; other site 941968001135 dimer interface [polypeptide binding]; other site 941968001136 catalytic triad [active] 941968001140 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 941968001141 phosphoglyceromutase; Provisional; Region: PRK05434 941968001147 enolase; Provisional; Region: eno; PRK00077 941968001148 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 941968001149 dimer interface [polypeptide binding]; other site 941968001150 metal binding site [ion binding]; metal-binding site 941968001151 substrate binding pocket [chemical binding]; other site 941968001156 1 probable transmembrane helix predicted for cbot00221 by TMHMM2.0 at aa 7-29 941968001158 Preprotein translocase SecG subunit; Region: SecG; pfam03840 941968001160 ribonuclease R; Region: RNase_R; TIGR02063 941968001161 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 941968001162 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941968001163 RNB domain; Region: RNB; pfam00773 941968001164 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 941968001165 RNA binding site [nucleotide binding]; other site 941968001175 stationary phase survival protein SurE; Provisional; Region: PRK13933 941968001178 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 941968001179 SmpB-tmRNA interface; other site 941968001181 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941968001182 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941968001188 MepB protein; Region: MepB; pfam08877 941968001190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941968001191 FAD binding domain; Region: FAD_binding_4; pfam01565 941968001192 Berberine and berberine like; Region: BBE; pfam08031 941968001194 1 probable transmembrane helix predicted for cbot00230 by TMHMM2.0 at aa 15-32 941968001197 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941968001198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968001199 S-adenosylmethionine binding site [chemical binding]; other site 941968001202 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968001203 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 941968001204 ligand binding site [chemical binding]; other site 941968001205 flexible hinge region; other site 941968001206 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941968001210 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 941968001211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968001212 catalytic residue [active] 941968001214 flagellin; Provisional; Region: PRK12804 941968001215 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968001216 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941968001221 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 941968001222 active site 941968001223 1 probable transmembrane helix predicted for cbot00238 by TMHMM2.0 at aa 33-55 941968001225 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 941968001229 lysine transporter; Provisional; Region: PRK10836 941968001231 1 probable transmembrane helix predicted for cbot00241 by TMHMM2.0 at aa 7-29 941968001233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968001234 potential frameshift: common BLAST hit: gi|384460696|ref|YP_005673291.1| metallo-beta-lactamase family protein 941968001236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941968001238 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 941968001239 active site 941968001240 catalytic motif [active] 941968001241 Zn binding site [ion binding]; other site 941968001243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968001244 Coenzyme A binding pocket [chemical binding]; other site 941968001247 1 probable transmembrane helix predicted for cbot00246 by TMHMM2.0 at aa 22-44 941968001249 RibD C-terminal domain; Region: RibD_C; cl17279 941968001250 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 941968001254 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 941968001255 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 941968001256 active site 941968001257 catalytic site [active] 941968001258 substrate binding site [chemical binding]; other site 941968001259 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 941968001260 Dimer interface [polypeptide binding]; other site 941968001265 Isochorismatase family; Region: Isochorismatase; pfam00857 941968001266 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 941968001267 catalytic triad [active] 941968001268 conserved cis-peptide bond; other site 941968001270 1 probable transmembrane helix predicted for cbot00249 by TMHMM2.0 at aa 15-37 941968001272 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941968001273 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941968001274 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941968001279 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 941968001280 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 941968001282 1 probable transmembrane helix predicted for cbot00251 by TMHMM2.0 at aa 38-60 941968001283 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941968001284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941968001285 catalytic loop [active] 941968001286 iron binding site [ion binding]; other site 941968001287 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941968001290 1 probable transmembrane helix predicted for cbot00252 by TMHMM2.0 at aa 64-86 941968001292 1 probable transmembrane helix predicted for cbot00253 by TMHMM2.0 at aa 5-24 941968001293 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 941968001294 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 941968001297 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941968001298 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941968001299 catalytic residues [active] 941968001301 1 probable transmembrane helix predicted for cbot00255 by TMHMM2.0 at aa 7-29 941968001303 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 941968001304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001305 active site 941968001306 phosphorylation site [posttranslational modification] 941968001307 intermolecular recognition site; other site 941968001308 dimerization interface [polypeptide binding]; other site 941968001309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968001310 DNA binding site [nucleotide binding] 941968001313 1 probable transmembrane helix predicted for cbot00256 by TMHMM2.0 at aa 20-42 941968001316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001317 HAMP domain; Region: HAMP; pfam00672 941968001318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968001319 dimer interface [polypeptide binding]; other site 941968001320 phosphorylation site [posttranslational modification] 941968001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001322 ATP binding site [chemical binding]; other site 941968001323 Mg2+ binding site [ion binding]; other site 941968001324 G-X-G motif; other site 941968001331 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941968001332 FAD binding domain; Region: FAD_binding_4; pfam01565 941968001334 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 941968001335 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 941968001336 NAD binding site [chemical binding]; other site 941968001337 sugar binding site [chemical binding]; other site 941968001338 divalent metal binding site [ion binding]; other site 941968001339 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968001340 dimer interface [polypeptide binding]; other site 941968001342 1 probable transmembrane helix predicted for cbot00259 by TMHMM2.0 at aa 27-49 941968001344 PTS system, maltose and glucose-specific IIBC component; Region: PTS-IIBC-malX; TIGR02004 941968001345 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968001346 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 941968001347 active site turn [active] 941968001348 phosphorylation site [posttranslational modification] 941968001354 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968001355 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968001356 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968001357 putative active site [active] 941968001360 1 probable transmembrane helix predicted for cbot00261 by TMHMM2.0 at aa 51-73 941968001361 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968001362 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968001363 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968001364 putative active site [active] 941968001368 1 probable transmembrane helix predicted for cbot00262 by TMHMM2.0 at aa 10-32 941968001369 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968001370 HPr interaction site; other site 941968001371 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968001372 active site 941968001373 phosphorylation site [posttranslational modification] 941968001376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968001377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001378 active site 941968001379 phosphorylation site [posttranslational modification] 941968001380 intermolecular recognition site; other site 941968001381 dimerization interface [polypeptide binding]; other site 941968001382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968001383 DNA binding site [nucleotide binding] 941968001388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001389 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 941968001390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001391 ATP binding site [chemical binding]; other site 941968001392 Mg2+ binding site [ion binding]; other site 941968001393 G-X-G motif; other site 941968001397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968001398 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968001399 Walker A/P-loop; other site 941968001400 ATP binding site [chemical binding]; other site 941968001401 Q-loop/lid; other site 941968001402 ABC transporter signature motif; other site 941968001403 Walker B; other site 941968001404 D-loop; other site 941968001405 H-loop/switch region; other site 941968001412 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 941968001413 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968001414 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968001415 active site turn [active] 941968001416 phosphorylation site [posttranslational modification] 941968001421 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 941968001422 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 941968001423 NAD binding site [chemical binding]; other site 941968001424 sugar binding site [chemical binding]; other site 941968001425 divalent metal binding site [ion binding]; other site 941968001426 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968001427 dimer interface [polypeptide binding]; other site 941968001431 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968001432 HPr interaction site; other site 941968001433 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968001434 active site 941968001435 phosphorylation site [posttranslational modification] 941968001437 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968001438 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968001439 putative active site [active] 941968001443 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941968001444 DNA-binding site [nucleotide binding]; DNA binding site 941968001445 RNA-binding motif; other site 941968001448 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 941968001450 Predicted transcriptional regulator [Transcription]; Region: COG1959 941968001451 Transcriptional regulator; Region: Rrf2; pfam02082 941968001454 1 probable transmembrane helix predicted for cbot00276 by TMHMM2.0 at aa 13-35 941968001455 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 941968001456 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 941968001457 catalytic residues [active] 941968001460 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 941968001461 NADH(P)-binding; Region: NAD_binding_10; pfam13460 941968001462 NAD binding site [chemical binding]; other site 941968001463 substrate binding site [chemical binding]; other site 941968001464 putative active site [active] 941968001468 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968001469 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968001470 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968001471 putative active site [active] 941968001475 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 941968001476 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968001477 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968001478 active site turn [active] 941968001479 phosphorylation site [posttranslational modification] 941968001482 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 941968001483 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 941968001484 NAD binding site [chemical binding]; other site 941968001485 sugar binding site [chemical binding]; other site 941968001486 divalent metal binding site [ion binding]; other site 941968001487 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968001488 dimer interface [polypeptide binding]; other site 941968001492 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968001493 HPr interaction site; other site 941968001494 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968001495 active site 941968001496 phosphorylation site [posttranslational modification] 941968001498 Dehydratase family; Region: ILVD_EDD; pfam00920 941968001501 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 941968001502 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 941968001503 active site 941968001504 intersubunit interface [polypeptide binding]; other site 941968001505 catalytic residue [active] 941968001508 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 941968001509 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941968001510 substrate binding site [chemical binding]; other site 941968001511 ATP binding site [chemical binding]; other site 941968001513 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 941968001514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968001515 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 941968001516 active site 941968001517 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 941968001519 1 probable transmembrane helix predicted for cbot00286 by TMHMM2.0 at aa 15-37 941968001521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968001522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001523 active site 941968001524 phosphorylation site [posttranslational modification] 941968001525 intermolecular recognition site; other site 941968001526 dimerization interface [polypeptide binding]; other site 941968001527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968001528 DNA binding site [nucleotide binding] 941968001531 1 probable transmembrane helix predicted for cbot00287 by TMHMM2.0 at aa 13-35 941968001534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968001536 dimerization interface [polypeptide binding]; other site 941968001537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968001538 dimer interface [polypeptide binding]; other site 941968001539 phosphorylation site [posttranslational modification] 941968001540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001541 ATP binding site [chemical binding]; other site 941968001542 Mg2+ binding site [ion binding]; other site 941968001543 G-X-G motif; other site 941968001550 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 941968001551 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941968001552 Ligand binding site; other site 941968001553 Putative Catalytic site; other site 941968001554 DXD motif; other site 941968001556 Predicted membrane protein [Function unknown]; Region: COG2246 941968001557 GtrA-like protein; Region: GtrA; pfam04138 941968001559 potential frameshift: common BLAST hit: gi|226947523|ref|YP_002802614.1| dolichyl-phosphate-mannose-protein mannosyltransferase family 941968001560 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 941968001561 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 941968001565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968001566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968001567 1 probable transmembrane helix predicted for cbot00293 by TMHMM2.0 at aa 24-46 941968001570 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941968001571 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968001572 intersubunit interface [polypeptide binding]; other site 941968001576 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968001577 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968001578 ABC-ATPase subunit interface; other site 941968001579 dimer interface [polypeptide binding]; other site 941968001580 putative PBP binding regions; other site 941968001583 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968001584 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968001585 Walker A/P-loop; other site 941968001586 ATP binding site [chemical binding]; other site 941968001587 Q-loop/lid; other site 941968001588 ABC transporter signature motif; other site 941968001589 Walker B; other site 941968001590 D-loop; other site 941968001591 H-loop/switch region; other site 941968001594 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968001595 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 941968001598 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 941968001599 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 941968001603 Thioesterase domain; Region: Thioesterase; pfam00975 941968001605 1 probable transmembrane helix predicted for cbot00300 by TMHMM2.0 at aa 12-34 941968001606 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941968001607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001608 active site 941968001609 phosphorylation site [posttranslational modification] 941968001610 intermolecular recognition site; other site 941968001611 dimerization interface [polypeptide binding]; other site 941968001612 LytTr DNA-binding domain; Region: LytTR; smart00850 941968001617 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 941968001619 Condensation domain; Region: Condensation; pfam00668 941968001620 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941968001621 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 941968001622 acyl-activating enzyme (AAE) consensus motif; other site 941968001623 AMP binding site [chemical binding]; other site 941968001624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001625 Condensation domain; Region: Condensation; pfam00668 941968001626 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941968001633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 941968001634 Beta-lactamase; Region: Beta-lactamase; pfam00144 941968001635 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 941968001636 Acyltransferase family; Region: Acyl_transf_3; pfam01757 941968001637 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 941968001638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968001639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968001640 Walker A/P-loop; other site 941968001641 ATP binding site [chemical binding]; other site 941968001642 ABC transporter signature motif; other site 941968001643 Walker B; other site 941968001644 D-loop; other site 941968001645 H-loop/switch region; other site 941968001652 Condensation domain; Region: Condensation; pfam00668 941968001653 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001654 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941968001655 acyl-activating enzyme (AAE) consensus motif; other site 941968001656 AMP binding site [chemical binding]; other site 941968001657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001658 Condensation domain; Region: Condensation; pfam00668 941968001659 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001660 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941968001661 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941968001662 acyl-activating enzyme (AAE) consensus motif; other site 941968001663 AMP binding site [chemical binding]; other site 941968001664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001665 Condensation domain; Region: Condensation; pfam00668 941968001666 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001667 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941968001668 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 941968001669 acyl-activating enzyme (AAE) consensus motif; other site 941968001670 AMP binding site [chemical binding]; other site 941968001671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001672 Condensation domain; Region: Condensation; pfam00668 941968001673 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001674 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941968001687 the sequence in this area is difficult to finish due to repeats, therefore there is a possiblity that this protein is not frameshifted and not a pseudogene 941968001691 Condensation domain; Region: Condensation; pfam00668 941968001692 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001693 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941968001694 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 941968001695 acyl-activating enzyme (AAE) consensus motif; other site 941968001696 AMP binding site [chemical binding]; other site 941968001697 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001698 Condensation domain; Region: Condensation; pfam00668 941968001699 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941968001700 Condensation domain; Region: Condensation; pfam00668 941968001701 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001702 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 941968001703 acyl-activating enzyme (AAE) consensus motif; other site 941968001704 AMP binding site [chemical binding]; other site 941968001705 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 941968001706 Condensation domain; Region: Condensation; pfam00668 941968001707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 941968001708 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 941968001709 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 941968001710 acyl-activating enzyme (AAE) consensus motif; other site 941968001711 AMP binding site [chemical binding]; other site 941968001712 Condensation domain; Region: Condensation; pfam00668 941968001713 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 941968001726 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968001727 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968001729 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941968001730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968001733 1 probable transmembrane helix predicted for cbot00312 by TMHMM2.0 at aa 34-53 941968001734 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941968001735 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968001736 intersubunit interface [polypeptide binding]; other site 941968001739 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968001740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968001741 ABC-ATPase subunit interface; other site 941968001742 dimer interface [polypeptide binding]; other site 941968001743 putative PBP binding regions; other site 941968001747 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 941968001748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968001749 ABC-ATPase subunit interface; other site 941968001750 dimer interface [polypeptide binding]; other site 941968001751 putative PBP binding regions; other site 941968001756 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968001757 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968001758 Walker A/P-loop; other site 941968001759 ATP binding site [chemical binding]; other site 941968001760 Q-loop/lid; other site 941968001761 ABC transporter signature motif; other site 941968001762 Walker B; other site 941968001763 D-loop; other site 941968001764 H-loop/switch region; other site 941968001769 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968001770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968001771 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941968001772 Walker A/P-loop; other site 941968001773 ATP binding site [chemical binding]; other site 941968001774 Q-loop/lid; other site 941968001775 ABC transporter signature motif; other site 941968001776 Walker B; other site 941968001777 D-loop; other site 941968001778 H-loop/switch region; other site 941968001783 xanthine permease; Region: pbuX; TIGR03173 941968001786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968001787 active site 941968001790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968001791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001792 active site 941968001793 phosphorylation site [posttranslational modification] 941968001794 intermolecular recognition site; other site 941968001795 dimerization interface [polypeptide binding]; other site 941968001796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968001797 DNA binding site [nucleotide binding] 941968001801 1 probable transmembrane helix predicted for cbot00321 by TMHMM2.0 at aa 31-53 941968001804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001805 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 941968001806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001807 ATP binding site [chemical binding]; other site 941968001808 Mg2+ binding site [ion binding]; other site 941968001809 G-X-G motif; other site 941968001813 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 941968001815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968001816 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968001817 Walker A/P-loop; other site 941968001818 ATP binding site [chemical binding]; other site 941968001819 Q-loop/lid; other site 941968001820 ABC transporter signature motif; other site 941968001821 Walker B; other site 941968001822 D-loop; other site 941968001823 H-loop/switch region; other site 941968001828 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968001829 FtsX-like permease family; Region: FtsX; pfam02687 941968001833 LrgA family; Region: LrgA; pfam03788 941968001835 LrgB-like family; Region: LrgB; pfam04172 941968001839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968001840 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941968001841 FeS/SAM binding site; other site 941968001842 1 probable transmembrane helix predicted for cbot00330 by TMHMM2.0 at aa 7-29 941968001845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 941968001846 hypothetical protein; Provisional; Region: PRK13663 941968001851 Accessory gene regulator B; Region: AgrB; pfam04647 941968001854 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 941968001855 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 941968001856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968001857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968001858 metal binding site [ion binding]; metal-binding site 941968001859 active site 941968001860 I-site; other site 941968001861 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941968001862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968001863 Zn2+ binding site [ion binding]; other site 941968001864 Mg2+ binding site [ion binding]; other site 941968001870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941968001871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941968001872 1 probable transmembrane helix predicted for cbot00337 by TMHMM2.0 at aa 5-27 941968001874 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 941968001875 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 941968001876 PAS domain; Region: PAS; smart00091 941968001877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968001878 dimer interface [polypeptide binding]; other site 941968001879 phosphorylation site [posttranslational modification] 941968001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001881 ATP binding site [chemical binding]; other site 941968001882 Mg2+ binding site [ion binding]; other site 941968001883 G-X-G motif; other site 941968001888 Accessory gene regulator B; Region: AgrB; pfam04647 941968001892 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 941968001893 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 941968001894 PAS domain S-box; Region: sensory_box; TIGR00229 941968001895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 941968001896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968001898 dimer interface [polypeptide binding]; other site 941968001899 phosphorylation site [posttranslational modification] 941968001900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001901 ATP binding site [chemical binding]; other site 941968001902 Mg2+ binding site [ion binding]; other site 941968001903 G-X-G motif; other site 941968001908 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 941968001909 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 941968001910 Ligand Binding Site [chemical binding]; other site 941968001912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968001913 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 941968001914 non-specific DNA binding site [nucleotide binding]; other site 941968001915 salt bridge; other site 941968001916 sequence-specific DNA binding site [nucleotide binding]; other site 941968001917 Cupin domain; Region: Cupin_2; pfam07883 941968001921 Amino acid permease; Region: AA_permease_2; pfam13520 941968001925 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941968001926 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941968001927 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 941968001928 active site 941968001934 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 941968001935 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 941968001936 putative catalytic cysteine [active] 941968001937 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 941968001938 putative active site [active] 941968001939 metal binding site [ion binding]; metal-binding site 941968001944 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 941968001946 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 941968001947 1 probable transmembrane helix predicted for cbot00350 by TMHMM2.0 at aa 46-64 941968001948 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 941968001950 1 probable transmembrane helix predicted for cbot00351 by TMHMM2.0 at aa 15-37 941968001952 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 941968001953 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941968001954 active site 941968001957 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941968001958 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 941968001959 NodB motif; other site 941968001960 active site 941968001961 catalytic site [active] 941968001962 Zn binding site [ion binding]; other site 941968001965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968001966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968001967 active site 941968001968 phosphorylation site [posttranslational modification] 941968001969 intermolecular recognition site; other site 941968001970 dimerization interface [polypeptide binding]; other site 941968001971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968001972 DNA binding site [nucleotide binding] 941968001977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968001978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968001979 dimerization interface [polypeptide binding]; other site 941968001980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968001981 dimer interface [polypeptide binding]; other site 941968001982 phosphorylation site [posttranslational modification] 941968001983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968001984 ATP binding site [chemical binding]; other site 941968001985 Mg2+ binding site [ion binding]; other site 941968001986 G-X-G motif; other site 941968001997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941968001998 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 941968002000 Uncharacterized conserved protein [Function unknown]; Region: COG0398 941968002001 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941968002006 potential frameshift: common BLAST hit: gi|170754902|ref|YP_001780010.1| multisensor diguanylate cyclase/phophodiesterase 941968002007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968002008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968002009 metal binding site [ion binding]; metal-binding site 941968002010 active site 941968002011 I-site; other site 941968002012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941968002017 1 probable transmembrane helix predicted for cbot00360 by TMHMM2.0 at aa 33-55 941968002019 potential frameshift: common BLAST hit: gi|153938294|ref|YP_001389725.1| multisensor diguanylate cyclase/phophodiesterase 941968002020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968002021 dimerization interface [polypeptide binding]; other site 941968002024 1 probable transmembrane helix predicted for cbot00361 by TMHMM2.0 at aa 44-61 941968002025 CHASE4 domain; Region: CHASE4; pfam05228 941968002028 1 probable transmembrane helix predicted for cbot00362 by TMHMM2.0 at aa 7-26 941968002029 Putative amidase domain; Region: Amidase_6; pfam12671 941968002031 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968002032 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 941968002036 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 941968002038 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941968002039 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941968002041 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941968002042 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968002043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968002044 catalytic residue [active] 941968002047 Predicted membrane protein [Function unknown]; Region: COG2855 941968002049 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 941968002050 active site 941968002052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968002053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968002054 intermolecular recognition site; other site 941968002055 active site 941968002056 dimerization interface [polypeptide binding]; other site 941968002057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968002058 DNA binding site [nucleotide binding] 941968002062 potential frameshift: common BLAST hit: gi|153934845|ref|YP_001386319.1| sensor histidine kinase 941968002063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968002064 dimerization interface [polypeptide binding]; other site 941968002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968002068 ATP binding site [chemical binding]; other site 941968002069 Mg2+ binding site [ion binding]; other site 941968002070 G-X-G motif; other site 941968002071 1 probable transmembrane helix predicted for cbot00373 by TMHMM2.0 at aa 26-48 941968002074 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 941968002075 Na binding site [ion binding]; other site 941968002080 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 941968002081 SLBB domain; Region: SLBB; pfam10531 941968002082 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968002086 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 941968002089 FMN-binding domain; Region: FMN_bind; cl01081 941968002094 electron transport complex RsxE subunit; Provisional; Region: PRK12405 941968002096 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 941968002098 ferredoxin; Validated; Region: PRK07118 941968002099 CheD chemotactic sensory transduction; Region: CheD; cl00810 941968002100 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968002107 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002108 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002109 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002114 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 941968002117 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 941968002118 trimer interface [polypeptide binding]; other site 941968002120 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 941968002121 ApbE family; Region: ApbE; pfam02424 941968002122 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 941968002123 ApbE family; Region: ApbE; pfam02424 941968002127 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002128 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002129 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002139 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002140 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002141 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002147 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002148 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002149 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002150 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 941968002151 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 941968002152 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 941968002153 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 941968002160 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 941968002161 Acyltransferase family; Region: Acyl_transf_3; pfam01757 941968002163 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941968002164 Bacterial Ig-like domain; Region: Big_5; pfam13205 941968002167 PBP superfamily domain; Region: PBP_like_2; cl17296 941968002170 1 probable transmembrane helix predicted for cbot00394 by TMHMM2.0 at aa 10-32 941968002171 PBP superfamily domain; Region: PBP_like_2; cl17296 941968002172 1 probable transmembrane helix predicted for cbot00395 by TMHMM2.0 at aa 42-64 941968002173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968002174 ABC-ATPase subunit interface; other site 941968002176 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 941968002177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968002178 dimer interface [polypeptide binding]; other site 941968002179 putative PBP binding loops; other site 941968002180 ABC-ATPase subunit interface; other site 941968002184 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 941968002185 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941968002186 Walker A/P-loop; other site 941968002187 ATP binding site [chemical binding]; other site 941968002188 Q-loop/lid; other site 941968002189 ABC transporter signature motif; other site 941968002190 Walker B; other site 941968002191 D-loop; other site 941968002192 H-loop/switch region; other site 941968002198 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968002200 amino acid transporter; Region: 2A0306; TIGR00909 941968002203 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 941968002210 1 probable transmembrane helix predicted for cbot00403 by TMHMM2.0 at aa 17-39 941968002211 Protein of unknown function DUF45; Region: DUF45; pfam01863 941968002214 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941968002215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941968002216 dimer interface [polypeptide binding]; other site 941968002217 ssDNA binding site [nucleotide binding]; other site 941968002218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968002220 Predicted membrane protein [Function unknown]; Region: COG1971 941968002222 1 probable transmembrane helix predicted for cbot00406 by TMHMM2.0 at aa 40-62 941968002224 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941968002225 metal binding site 2 [ion binding]; metal-binding site 941968002226 putative DNA binding helix; other site 941968002227 metal binding site 1 [ion binding]; metal-binding site 941968002228 dimer interface [polypeptide binding]; other site 941968002229 structural Zn2+ binding site [ion binding]; other site 941968002231 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941968002232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968002233 Zn2+ binding site [ion binding]; other site 941968002234 Mg2+ binding site [ion binding]; other site 941968002235 1 probable transmembrane helix predicted for cbot00409 by TMHMM2.0 at aa 21-43 941968002238 Rhomboid family; Region: Rhomboid; pfam01694 941968002240 Cache domain; Region: Cache_1; pfam02743 941968002241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968002242 dimerization interface [polypeptide binding]; other site 941968002243 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968002244 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968002245 dimer interface [polypeptide binding]; other site 941968002246 putative CheW interface [polypeptide binding]; other site 941968002253 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 941968002254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968002255 Walker A motif; other site 941968002256 ATP binding site [chemical binding]; other site 941968002257 Walker B motif; other site 941968002258 arginine finger; other site 941968002259 Peptidase family M41; Region: Peptidase_M41; pfam01434 941968002266 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 941968002269 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 941968002270 RNA/DNA hybrid binding site [nucleotide binding]; other site 941968002271 active site 941968002273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968002274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968002275 non-specific DNA binding site [nucleotide binding]; other site 941968002276 salt bridge; other site 941968002277 sequence-specific DNA binding site [nucleotide binding]; other site 941968002278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968002279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968002280 binding surface 941968002281 TPR motif; other site 941968002282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968002283 Helix-turn-helix domain; Region: HTH_19; pfam12844 941968002284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968002286 1 probable transmembrane helix predicted for cbot00418 by TMHMM2.0 at aa 10-32 941968002292 1 probable transmembrane helix predicted for cbot00419 by TMHMM2.0 at aa 4-26 941968002293 DJ-1 family protein; Region: not_thiJ; TIGR01383 941968002294 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 941968002295 conserved cys residue [active] 941968002298 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941968002299 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941968002303 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 941968002304 Clp amino terminal domain; Region: Clp_N; pfam02861 941968002305 Clp amino terminal domain; Region: Clp_N; pfam02861 941968002306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968002307 Walker A motif; other site 941968002308 ATP binding site [chemical binding]; other site 941968002309 Walker B motif; other site 941968002310 arginine finger; other site 941968002311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968002312 Walker A motif; other site 941968002313 ATP binding site [chemical binding]; other site 941968002314 Walker B motif; other site 941968002315 arginine finger; other site 941968002316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941968002325 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 941968002326 catalytic triad [active] 941968002329 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 941968002330 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968002331 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 941968002335 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 941968002336 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 941968002340 1 probable transmembrane helix predicted for cbot00426 by TMHMM2.0 at aa 7-26 941968002341 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 941968002344 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 941968002345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941968002348 1 probable transmembrane helix predicted for cbot00429 by TMHMM2.0 at aa 26-48 941968002350 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941968002351 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941968002352 putative acyl-acceptor binding pocket; other site 941968002356 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 941968002357 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 941968002358 active site 941968002359 catalytic residues [active] 941968002360 metal binding site [ion binding]; metal-binding site 941968002361 1 probable transmembrane helix predicted for cbot00431 by TMHMM2.0 at aa 10-32 941968002363 aconitate hydratase; Validated; Region: PRK07229 941968002364 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 941968002365 substrate binding site [chemical binding]; other site 941968002366 ligand binding site [chemical binding]; other site 941968002367 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 941968002368 substrate binding site [chemical binding]; other site 941968002374 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 941968002375 tartrate dehydrogenase; Region: TTC; TIGR02089 941968002379 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941968002380 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941968002381 Walker A/P-loop; other site 941968002382 ATP binding site [chemical binding]; other site 941968002383 Q-loop/lid; other site 941968002384 ABC transporter signature motif; other site 941968002385 Walker B; other site 941968002386 D-loop; other site 941968002387 H-loop/switch region; other site 941968002393 Permease; Region: Permease; cl00510 941968002394 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 941968002399 Uncharacterized conserved protein [Function unknown]; Region: COG2155 941968002401 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 941968002402 tetramerization interface [polypeptide binding]; other site 941968002403 active site 941968002405 Pantoate-beta-alanine ligase; Region: PanC; cd00560 941968002406 active site 941968002407 ATP-binding site [chemical binding]; other site 941968002408 pantoate-binding site; other site 941968002409 HXXH motif; other site 941968002412 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 941968002413 oligomerization interface [polypeptide binding]; other site 941968002414 active site 941968002415 metal binding site [ion binding]; metal-binding site 941968002418 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 941968002419 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941968002421 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 941968002426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968002427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968002429 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968002431 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 941968002432 4Fe-4S binding domain; Region: Fer4; pfam00037 941968002433 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 941968002434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968002442 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 941968002443 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 941968002448 1 probable transmembrane helix predicted for cbot00449 by TMHMM2.0 at aa 10-32 941968002449 potential frameshift: common BLAST hit: gi|384460878|ref|YP_005673473.1| recombination helicase AddA 941968002450 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 941968002452 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 941968002453 Family description; Region: UvrD_C_2; pfam13538 941968002454 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941968002460 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941968002461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968002462 dimer interface [polypeptide binding]; other site 941968002463 putative CheW interface [polypeptide binding]; other site 941968002466 peptidase T; Region: peptidase-T; TIGR01882 941968002467 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 941968002468 metal binding site [ion binding]; metal-binding site 941968002469 dimer interface [polypeptide binding]; other site 941968002475 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 941968002476 active site 941968002477 nucleophile elbow; other site 941968002480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968002483 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 941968002484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941968002487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968002488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968002489 non-specific DNA binding site [nucleotide binding]; other site 941968002490 salt bridge; other site 941968002491 sequence-specific DNA binding site [nucleotide binding]; other site 941968002494 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002495 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002496 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968002503 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941968002504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968002505 dimer interface [polypeptide binding]; other site 941968002506 conserved gate region; other site 941968002507 putative PBP binding loops; other site 941968002508 ABC-ATPase subunit interface; other site 941968002509 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941968002510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941968002511 substrate binding pocket [chemical binding]; other site 941968002512 membrane-bound complex binding site; other site 941968002513 hinge residues; other site 941968002514 1 probable transmembrane helix predicted for cbot00462 by TMHMM2.0 at aa 5-22 941968002517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968002518 S-adenosylmethionine binding site [chemical binding]; other site 941968002520 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 941968002521 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941968002525 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941968002526 thiamine phosphate binding site [chemical binding]; other site 941968002527 active site 941968002528 pyrophosphate binding site [ion binding]; other site 941968002529 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 941968002530 substrate binding site [chemical binding]; other site 941968002531 multimerization interface [polypeptide binding]; other site 941968002532 ATP binding site [chemical binding]; other site 941968002535 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941968002536 dimer interface [polypeptide binding]; other site 941968002537 substrate binding site [chemical binding]; other site 941968002538 ATP binding site [chemical binding]; other site 941968002541 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 941968002542 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 941968002543 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941968002546 1 probable transmembrane helix predicted for cbot00469 by TMHMM2.0 at aa 15-37 941968002549 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 941968002550 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 941968002551 dimerization interface [polypeptide binding]; other site 941968002552 ligand binding site [chemical binding]; other site 941968002557 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941968002558 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 941968002559 TM-ABC transporter signature motif; other site 941968002561 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 941968002562 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 941968002563 TM-ABC transporter signature motif; other site 941968002567 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 941968002568 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 941968002569 Walker A/P-loop; other site 941968002570 ATP binding site [chemical binding]; other site 941968002571 Q-loop/lid; other site 941968002572 ABC transporter signature motif; other site 941968002573 Walker B; other site 941968002574 D-loop; other site 941968002575 H-loop/switch region; other site 941968002576 1 probable transmembrane helix predicted for cbot00473 by TMHMM2.0 at aa 13-35 941968002580 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 941968002581 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 941968002582 Walker A/P-loop; other site 941968002583 ATP binding site [chemical binding]; other site 941968002584 Q-loop/lid; other site 941968002585 ABC transporter signature motif; other site 941968002586 Walker B; other site 941968002587 D-loop; other site 941968002588 H-loop/switch region; other site 941968002589 1 probable transmembrane helix predicted for cbot00474 by TMHMM2.0 at aa 10-32 941968002593 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 941968002595 Uncharacterized conserved protein [Function unknown]; Region: COG2966 941968002596 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 941968002598 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 941968002601 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968002602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968002603 DNA-binding site [nucleotide binding]; DNA binding site 941968002604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968002605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968002606 homodimer interface [polypeptide binding]; other site 941968002607 catalytic residue [active] 941968002611 LemA family; Region: LemA; pfam04011 941968002613 1 probable transmembrane helix predicted for cbot00479 by TMHMM2.0 at aa 7-29 941968002615 Repair protein; Region: Repair_PSII; pfam04536 941968002621 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 941968002622 nudix motif; other site 941968002626 1 probable transmembrane helix predicted for cbot00481 by TMHMM2.0 at aa 13-35 941968002627 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 941968002630 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941968002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968002632 S-adenosylmethionine binding site [chemical binding]; other site 941968002633 1 probable transmembrane helix predicted for cbot00484 by TMHMM2.0 at aa 33-55 941968002635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968002636 salt bridge; other site 941968002637 non-specific DNA binding site [nucleotide binding]; other site 941968002638 sequence-specific DNA binding site [nucleotide binding]; other site 941968002641 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 941968002644 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 941968002645 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 941968002646 active site 941968002647 metal binding site [ion binding]; metal-binding site 941968002648 DNA binding site [nucleotide binding] 941968002649 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 941968002654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968002655 AAA domain; Region: AAA_23; pfam13476 941968002656 Walker A/P-loop; other site 941968002657 ATP binding site [chemical binding]; other site 941968002658 Q-loop/lid; other site 941968002659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968002660 ABC transporter signature motif; other site 941968002661 Walker B; other site 941968002662 D-loop; other site 941968002663 H-loop/switch region; other site 941968002665 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 941968002666 ADP-ribose binding site [chemical binding]; other site 941968002667 dimer interface [polypeptide binding]; other site 941968002668 active site 941968002669 nudix motif; other site 941968002670 metal binding site [ion binding]; metal-binding site 941968002671 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941968002672 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941968002673 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941968002674 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941968002676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968002677 dimerization interface [polypeptide binding]; other site 941968002678 putative DNA binding site [nucleotide binding]; other site 941968002679 putative Zn2+ binding site [ion binding]; other site 941968002682 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941968002683 Heavy-metal-associated domain; Region: HMA; pfam00403 941968002684 metal-binding site [ion binding] 941968002685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968002686 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968002688 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941968002689 NlpC/P60 family; Region: NLPC_P60; pfam00877 941968002693 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941968002694 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941968002700 potential frameshift: common BLAST hit: gi|170758851|ref|YP_001785829.1| membrane-spanning protein 941968002701 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 941968002705 1 probable transmembrane helix predicted for cbot00500 by TMHMM2.0 at aa 5-27 941968002707 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 941968002708 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 941968002709 putative active site [active] 941968002710 PhoH-like protein; Region: PhoH; pfam02562 941968002715 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 941968002718 1 probable transmembrane helix predicted for cbot00504 by TMHMM2.0 at aa 33-55 941968002721 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 941968002722 NADPH bind site [chemical binding]; other site 941968002723 putative FMN binding site [chemical binding]; other site 941968002724 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 941968002725 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 941968002726 potential frameshift: common BLAST hit: gi|153935261|ref|YP_001386446.1| streptolysin associated protein SagD 941968002727 YcaO-like family; Region: YcaO; pfam02624 941968002728 YcaO-like family; Region: YcaO; pfam02624 941968002729 CAAX protease self-immunity; Region: Abi; pfam02517 941968002733 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968002734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968002735 Walker A/P-loop; other site 941968002736 ATP binding site [chemical binding]; other site 941968002737 Q-loop/lid; other site 941968002738 ABC transporter signature motif; other site 941968002739 Walker B; other site 941968002740 D-loop; other site 941968002741 H-loop/switch region; other site 941968002743 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941968002744 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941968002745 YcaO-like family; Region: YcaO; pfam02624 941968002746 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941968002747 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941968002748 ABC-2 type transporter; Region: ABC2_membrane; cl17235 941968002750 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 941968002751 Peptidase family M50; Region: Peptidase_M50; pfam02163 941968002752 active site 941968002753 putative substrate binding region [chemical binding]; other site 941968002756 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 941968002757 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 941968002758 transmembrane helices; other site 941968002761 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 941968002764 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 941968002765 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 941968002766 dimer interface [polypeptide binding]; other site 941968002767 catalytic triad [active] 941968002768 peroxidatic and resolving cysteines [active] 941968002770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941968002771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968002772 NAD(P) binding site [chemical binding]; other site 941968002773 active site 941968002775 Response regulator receiver domain; Region: Response_reg; pfam00072 941968002776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968002777 active site 941968002778 phosphorylation site [posttranslational modification] 941968002779 intermolecular recognition site; other site 941968002780 dimerization interface [polypeptide binding]; other site 941968002781 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 941968002784 CHAP domain; Region: CHAP; pfam05257 941968002785 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968002786 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968002787 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 941968002788 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968002789 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941968002790 NlpC/P60 family; Region: NLPC_P60; pfam00877 941968002803 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941968002804 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941968002807 PAS fold; Region: PAS_4; pfam08448 941968002808 Response regulator receiver domain; Region: Response_reg; pfam00072 941968002809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968002810 active site 941968002811 phosphorylation site [posttranslational modification] 941968002812 intermolecular recognition site; other site 941968002813 dimerization interface [polypeptide binding]; other site 941968002814 Hpt domain; Region: Hpt; pfam01627 941968002821 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941968002822 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968002823 Zn2+ binding site [ion binding]; other site 941968002824 Mg2+ binding site [ion binding]; other site 941968002825 1 probable transmembrane helix predicted for cbot00525 by TMHMM2.0 at aa 9-31 941968002828 Cache domain; Region: Cache_1; pfam02743 941968002829 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 941968002830 dimerization interface [polypeptide binding]; other site 941968002831 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968002832 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968002833 dimer interface [polypeptide binding]; other site 941968002834 putative CheW interface [polypeptide binding]; other site 941968002838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968002839 active site 941968002840 phosphorylation site [posttranslational modification] 941968002841 intermolecular recognition site; other site 941968002842 dimerization interface [polypeptide binding]; other site 941968002843 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 941968002847 potential frameshift: common BLAST hit: gi|170754762|ref|YP_001780158.1| seryl-tRNA synthetase 941968002848 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 941968002850 seryl-tRNA synthetase; Provisional; Region: PRK05431 941968002851 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941968002852 motif 1; other site 941968002853 dimer interface [polypeptide binding]; other site 941968002854 active site 941968002855 motif 2; other site 941968002856 motif 3; other site 941968002858 potential frameshift: common BLAST hit: gi|153936609|ref|YP_001386468.1| ATP-dependent helicase 941968002859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941968002862 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 941968002863 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 941968002865 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968002866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968002867 DNA-binding site [nucleotide binding]; DNA binding site 941968002868 TrkA-C domain; Region: TrkA_C; pfam02080 941968002872 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 941968002873 putative active site [active] 941968002874 putative ligand binding site [chemical binding]; other site 941968002875 putative NAD(P) binding site [chemical binding]; other site 941968002877 1 probable transmembrane helix predicted for cbot00534 by TMHMM2.0 at aa 22-44 941968002879 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 941968002881 1 probable transmembrane helix predicted for cbot00535 by TMHMM2.0 at aa 15-34 941968002883 Hemerythrin; Region: Hemerythrin; cd12107 941968002884 Fe binding site [ion binding]; other site 941968002888 1 probable transmembrane helix predicted for cbot00539 by TMHMM2.0 at aa 78-92 941968002889 1 probable transmembrane helix predicted for cbot00540 by TMHMM2.0 at aa 18-40 941968002890 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 941968002891 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941968002893 1 probable transmembrane helix predicted for cbot00541 by TMHMM2.0 at aa 21-39 941968002894 potential frameshift: common BLAST hit: gi|153935440|ref|YP_001386478.1| metallo-beta-lactamase 941968002895 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 941968002896 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 941968002897 1 probable transmembrane helix predicted for cbot00544 by TMHMM2.0 at aa 15-46 941968002899 Amino acid permease; Region: AA_permease_2; pfam13520 941968002901 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 941968002902 AsnC family; Region: AsnC_trans_reg; pfam01037 941968002906 1 probable transmembrane helix predicted for cbot00548 by TMHMM2.0 at aa 15-37 941968002907 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 941968002908 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 941968002911 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 941968002912 Spore germination protein; Region: Spore_permease; cl17796 941968002916 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941968002917 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 941968002918 trimer interface [polypeptide binding]; other site 941968002919 putative metal binding site [ion binding]; other site 941968002921 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 941968002922 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941968002926 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 941968002927 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968002928 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968002929 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968002930 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968002931 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968002939 Chromate transporter; Region: Chromate_transp; pfam02417 941968002942 Chromate transporter; Region: Chromate_transp; pfam02417 941968002945 PemK-like protein; Region: PemK; pfam02452 941968002948 Protein of unknown function (DUF327); Region: DUF327; cl00753 941968002950 Protein of unknown function (DUF327); Region: DUF327; pfam03885 941968002952 NAD synthetase; Reviewed; Region: nadE; PRK02628 941968002953 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 941968002954 multimer interface [polypeptide binding]; other site 941968002955 active site 941968002956 catalytic triad [active] 941968002957 protein interface 1 [polypeptide binding]; other site 941968002958 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 941968002959 homodimer interface [polypeptide binding]; other site 941968002960 NAD binding pocket [chemical binding]; other site 941968002961 ATP binding pocket [chemical binding]; other site 941968002962 Mg binding site [ion binding]; other site 941968002963 active-site loop [active] 941968002968 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 941968002969 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 941968002971 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941968002972 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 941968002976 potential frameshift: common BLAST hit: gi|170759178|ref|YP_001785888.1| CAAX amino terminal protease 941968002978 potential frameshift: common BLAST hit: gi|170757623|ref|YP_001780188.1| CAAX amino terminal protease 941968002979 1 probable transmembrane helix predicted for cbot00566 by TMHMM2.0 at aa 10-32 941968002980 proline aminopeptidase P II; Provisional; Region: PRK10879 941968002981 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 941968002982 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 941968002983 active site 941968002986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968002987 salt bridge; other site 941968002988 non-specific DNA binding site [nucleotide binding]; other site 941968002989 sequence-specific DNA binding site [nucleotide binding]; other site 941968002992 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941968002993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968002994 Coenzyme A binding pocket [chemical binding]; other site 941968002996 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 941968002998 1 probable transmembrane helix predicted for cbot00571 by TMHMM2.0 at aa 27-49 941968002999 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941968003000 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941968003004 1 probable transmembrane helix predicted for cbot00574 by TMHMM2.0 at aa 33-52 941968003005 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 941968003006 Carbon starvation protein CstA; Region: CstA; pfam02554 941968003007 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 941968003011 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 941968003015 Cache domain; Region: Cache_1; pfam02743 941968003016 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968003017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968003018 dimer interface [polypeptide binding]; other site 941968003019 putative CheW interface [polypeptide binding]; other site 941968003025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968003026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968003027 ABC transporter; Region: ABC_tran_2; pfam12848 941968003028 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941968003029 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968003034 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 941968003035 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 941968003038 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 941968003040 1 probable transmembrane helix predicted for cbot00584 by TMHMM2.0 at aa 5-24 941968003041 SEC-C motif; Region: SEC-C; pfam02810 941968003044 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968003045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968003046 DNA-binding site [nucleotide binding]; DNA binding site 941968003049 1 probable transmembrane helix predicted for cbot00586 by TMHMM2.0 at aa 35-54 941968003050 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 941968003051 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968003052 Walker A/P-loop; other site 941968003053 ATP binding site [chemical binding]; other site 941968003054 Q-loop/lid; other site 941968003055 ABC transporter signature motif; other site 941968003056 Walker B; other site 941968003057 D-loop; other site 941968003058 H-loop/switch region; other site 941968003064 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941968003065 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 941968003066 Walker A/P-loop; other site 941968003067 ATP binding site [chemical binding]; other site 941968003068 Q-loop/lid; other site 941968003069 ABC transporter signature motif; other site 941968003070 Walker B; other site 941968003071 D-loop; other site 941968003072 H-loop/switch region; other site 941968003073 TOBE domain; Region: TOBE_2; pfam08402 941968003075 1 probable transmembrane helix predicted for cbot00589 by TMHMM2.0 at aa 15-37 941968003079 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 941968003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968003081 dimer interface [polypeptide binding]; other site 941968003082 conserved gate region; other site 941968003083 putative PBP binding loops; other site 941968003084 ABC-ATPase subunit interface; other site 941968003086 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941968003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968003088 dimer interface [polypeptide binding]; other site 941968003089 conserved gate region; other site 941968003090 putative PBP binding loops; other site 941968003091 ABC-ATPase subunit interface; other site 941968003092 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941968003093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941968003099 Transcriptional regulator PadR-like family; Region: PadR; cl17335 941968003102 1 probable transmembrane helix predicted for cbot00593 by TMHMM2.0 at aa 55-77 941968003106 1 probable transmembrane helix predicted for cbot00596 by TMHMM2.0 at aa 32-54 941968003107 1 probable transmembrane helix predicted for cbot00598 by TMHMM2.0 at aa 23-45 941968003114 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968003115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968003117 1 probable transmembrane helix predicted for cbot00605 by TMHMM2.0 at aa 12-34 941968003118 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 941968003119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968003120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003121 Walker A/P-loop; other site 941968003122 ATP binding site [chemical binding]; other site 941968003123 Q-loop/lid; other site 941968003124 ABC transporter signature motif; other site 941968003125 Walker B; other site 941968003126 D-loop; other site 941968003127 H-loop/switch region; other site 941968003133 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 941968003134 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 941968003135 putative active site [active] 941968003136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968003137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003138 Walker A/P-loop; other site 941968003139 ATP binding site [chemical binding]; other site 941968003140 Q-loop/lid; other site 941968003141 ABC transporter signature motif; other site 941968003142 Walker B; other site 941968003143 D-loop; other site 941968003144 H-loop/switch region; other site 941968003151 1 probable transmembrane helix predicted for cbot00608 by TMHMM2.0 at aa 34-56 941968003152 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 941968003153 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 941968003154 active site 941968003155 zinc binding site [ion binding]; other site 941968003156 1 probable transmembrane helix predicted for cbot00611 by TMHMM2.0 at aa 26-48 941968003158 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 941968003159 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 941968003160 active site 941968003161 zinc binding site [ion binding]; other site 941968003163 1 probable transmembrane helix predicted for cbot00612 by TMHMM2.0 at aa 57-79 941968003168 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968003169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003170 Walker A/P-loop; other site 941968003171 ATP binding site [chemical binding]; other site 941968003172 Q-loop/lid; other site 941968003173 ABC transporter signature motif; other site 941968003174 Walker B; other site 941968003175 D-loop; other site 941968003176 H-loop/switch region; other site 941968003179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 941968003180 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968003182 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941968003183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941968003185 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941968003186 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968003187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968003192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941968003193 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941968003195 putative acetyltransferase; Provisional; Region: PRK03624 941968003196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968003197 Coenzyme A binding pocket [chemical binding]; other site 941968003199 CAAX protease self-immunity; Region: Abi; pfam02517 941968003202 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 941968003203 putative tRNA-binding site [nucleotide binding]; other site 941968003205 1 probable transmembrane helix predicted for cbot00628 by TMHMM2.0 at aa 93-115 941968003206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968003207 non-specific DNA binding site [nucleotide binding]; other site 941968003208 salt bridge; other site 941968003209 sequence-specific DNA binding site [nucleotide binding]; other site 941968003213 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 941968003214 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941968003215 Catalytic site [active] 941968003217 1 probable transmembrane helix predicted for cbot00632 by TMHMM2.0 at aa 10-32 941968003219 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941968003220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968003221 active site 941968003222 phosphorylation site [posttranslational modification] 941968003223 intermolecular recognition site; other site 941968003224 dimerization interface [polypeptide binding]; other site 941968003225 LytTr DNA-binding domain; Region: LytTR; smart00850 941968003230 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 941968003231 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 941968003232 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 941968003233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968003234 FeS/SAM binding site; other site 941968003235 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 941968003238 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 941968003239 1 probable transmembrane helix predicted for cbot00639 by TMHMM2.0 at aa 21-43 941968003240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968003241 Coenzyme A binding pocket [chemical binding]; other site 941968003242 1 probable transmembrane helix predicted for cbot00640 by TMHMM2.0 at aa 40-62 941968003243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968003244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968003245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003246 Walker A/P-loop; other site 941968003247 ATP binding site [chemical binding]; other site 941968003248 Q-loop/lid; other site 941968003249 ABC transporter signature motif; other site 941968003250 Walker B; other site 941968003251 D-loop; other site 941968003252 H-loop/switch region; other site 941968003257 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941968003258 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 941968003259 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968003260 FtsX-like permease family; Region: FtsX; pfam02687 941968003261 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968003262 FtsX-like permease family; Region: FtsX; pfam02687 941968003266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968003267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968003268 Walker A/P-loop; other site 941968003269 ATP binding site [chemical binding]; other site 941968003270 Q-loop/lid; other site 941968003271 ABC transporter signature motif; other site 941968003272 Walker B; other site 941968003273 D-loop; other site 941968003274 H-loop/switch region; other site 941968003278 EDD domain protein, DegV family; Region: DegV; TIGR00762 941968003279 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941968003281 1 probable transmembrane helix predicted for cbot00647 by TMHMM2.0 at aa 10-32 941968003283 hypothetical protein; Provisional; Region: PRK04164 941968003286 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 941968003287 Sulfatase; Region: Sulfatase; pfam00884 941968003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968003290 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 941968003291 Walker A motif; other site 941968003292 ATP binding site [chemical binding]; other site 941968003293 Walker B motif; other site 941968003294 arginine finger; other site 941968003295 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968003301 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 941968003302 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 941968003303 Nucleoside recognition; Region: Gate; pfam07670 941968003304 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 941968003310 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 941968003311 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 941968003312 putative dimer interface [polypeptide binding]; other site 941968003313 putative anticodon binding site; other site 941968003314 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 941968003315 homodimer interface [polypeptide binding]; other site 941968003316 motif 1; other site 941968003317 motif 2; other site 941968003318 active site 941968003319 motif 3; other site 941968003322 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968003323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968003324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968003325 DNA binding residues [nucleotide binding] 941968003328 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968003329 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 941968003330 Walker A/P-loop; other site 941968003331 ATP binding site [chemical binding]; other site 941968003332 Q-loop/lid; other site 941968003333 ABC transporter signature motif; other site 941968003334 Walker B; other site 941968003335 D-loop; other site 941968003336 H-loop/switch region; other site 941968003339 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941968003340 Predicted transcriptional regulators [Transcription]; Region: COG1695 941968003341 Transcriptional regulator PadR-like family; Region: PadR; cl17335 941968003344 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 941968003347 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968003350 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941968003351 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968003352 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 941968003353 LytTr DNA-binding domain; Region: LytTR; smart00850 941968003354 1 probable transmembrane helix predicted for cbot00661 by TMHMM2.0 at aa 26-44 941968003359 potential frameshift: common BLAST hit: gi|384461034|ref|YP_005673629.1| AraC family transcriptional regulator 941968003360 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941968003361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968003364 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 941968003367 1 probable transmembrane helix predicted for cbot00664 by TMHMM2.0 at aa 4-23 941968003369 potential frameshift: common BLAST hit: gi|384461035|ref|YP_005673630.1| CAAX amino terminal protease family protein 941968003372 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968003373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968003374 non-specific DNA binding site [nucleotide binding]; other site 941968003375 salt bridge; other site 941968003376 sequence-specific DNA binding site [nucleotide binding]; other site 941968003380 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 941968003385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968003386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968003387 active site 941968003388 phosphorylation site [posttranslational modification] 941968003389 intermolecular recognition site; other site 941968003390 dimerization interface [polypeptide binding]; other site 941968003391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968003392 DNA binding site [nucleotide binding] 941968003396 1 probable transmembrane helix predicted for cbot00669 by TMHMM2.0 at aa 36-58 941968003399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968003400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968003401 dimerization interface [polypeptide binding]; other site 941968003402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968003403 dimer interface [polypeptide binding]; other site 941968003404 phosphorylation site [posttranslational modification] 941968003405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968003406 ATP binding site [chemical binding]; other site 941968003407 Mg2+ binding site [ion binding]; other site 941968003408 G-X-G motif; other site 941968003418 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 941968003419 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 941968003421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968003422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968003423 active site 941968003424 phosphorylation site [posttranslational modification] 941968003425 intermolecular recognition site; other site 941968003426 dimerization interface [polypeptide binding]; other site 941968003427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968003428 DNA binding site [nucleotide binding] 941968003434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968003435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968003436 dimer interface [polypeptide binding]; other site 941968003437 phosphorylation site [posttranslational modification] 941968003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968003439 ATP binding site [chemical binding]; other site 941968003440 Mg2+ binding site [ion binding]; other site 941968003441 G-X-G motif; other site 941968003447 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 941968003448 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 941968003451 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941968003452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968003453 active site 941968003454 phosphorylation site [posttranslational modification] 941968003455 intermolecular recognition site; other site 941968003456 dimerization interface [polypeptide binding]; other site 941968003457 YcbB domain; Region: YcbB; pfam08664 941968003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968003462 ATP binding site [chemical binding]; other site 941968003463 Mg2+ binding site [ion binding]; other site 941968003464 G-X-G motif; other site 941968003467 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 941968003469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968003470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968003471 dimerization interface [polypeptide binding]; other site 941968003472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968003473 dimer interface [polypeptide binding]; other site 941968003474 phosphorylation site [posttranslational modification] 941968003475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968003476 ATP binding site [chemical binding]; other site 941968003477 Mg2+ binding site [ion binding]; other site 941968003478 G-X-G motif; other site 941968003485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968003486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968003487 active site 941968003488 phosphorylation site [posttranslational modification] 941968003489 intermolecular recognition site; other site 941968003490 dimerization interface [polypeptide binding]; other site 941968003491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968003492 DNA binding site [nucleotide binding] 941968003497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968003498 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 941968003499 Walker A/P-loop; other site 941968003500 ATP binding site [chemical binding]; other site 941968003501 Q-loop/lid; other site 941968003502 ABC transporter signature motif; other site 941968003503 Walker B; other site 941968003504 D-loop; other site 941968003505 H-loop/switch region; other site 941968003512 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968003514 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 941968003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941968003516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968003517 S-adenosylmethionine binding site [chemical binding]; other site 941968003520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968003521 dimerization interface [polypeptide binding]; other site 941968003522 putative Zn2+ binding site [ion binding]; other site 941968003523 putative DNA binding site [nucleotide binding]; other site 941968003526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968003527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968003528 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 941968003529 Walker A/P-loop; other site 941968003530 ATP binding site [chemical binding]; other site 941968003531 Q-loop/lid; other site 941968003532 ABC transporter signature motif; other site 941968003533 Walker B; other site 941968003534 D-loop; other site 941968003535 H-loop/switch region; other site 941968003537 1 probable transmembrane helix predicted for cbot00688 by TMHMM2.0 at aa 10-29 941968003541 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 941968003542 Chloramphenicol acetyltransferase; Region: CAT; smart01059 941968003544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968003545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968003547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968003549 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 941968003550 dimer interface [polypeptide binding]; other site 941968003551 putative tRNA-binding site [nucleotide binding]; other site 941968003553 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941968003554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968003555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968003560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968003561 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 941968003562 non-specific DNA binding site [nucleotide binding]; other site 941968003563 salt bridge; other site 941968003564 sequence-specific DNA binding site [nucleotide binding]; other site 941968003565 Cupin domain; Region: Cupin_2; pfam07883 941968003569 1 probable transmembrane helix predicted for cbot00694 by TMHMM2.0 at aa 13-35 941968003570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 941968003571 Zn2+ binding site [ion binding]; other site 941968003572 Mg2+ binding site [ion binding]; other site 941968003573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003574 Q-loop/lid; other site 941968003575 1 probable transmembrane helix predicted for cbot00696 by TMHMM2.0 at aa 31-53 941968003576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968003577 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968003578 Walker A/P-loop; other site 941968003579 ATP binding site [chemical binding]; other site 941968003580 Q-loop/lid; other site 941968003581 ABC transporter signature motif; other site 941968003582 Walker B; other site 941968003583 D-loop; other site 941968003584 H-loop/switch region; other site 941968003588 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941968003592 allantoate amidohydrolase; Reviewed; Region: PRK09290 941968003593 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 941968003594 active site 941968003595 metal binding site [ion binding]; metal-binding site 941968003596 dimer interface [polypeptide binding]; other site 941968003599 1 probable transmembrane helix predicted for cbot00699 by TMHMM2.0 at aa 27-46 941968003601 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 941968003602 MutS domain III; Region: MutS_III; pfam05192 941968003603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003604 Walker A/P-loop; other site 941968003605 ATP binding site [chemical binding]; other site 941968003606 Q-loop/lid; other site 941968003607 ABC transporter signature motif; other site 941968003608 Walker B; other site 941968003609 D-loop; other site 941968003610 H-loop/switch region; other site 941968003616 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 941968003617 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941968003620 Protein of unknown function (DUF454); Region: DUF454; cl01063 941968003622 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941968003625 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968003626 minor groove reading motif; other site 941968003629 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968003630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968003631 DNA-binding site [nucleotide binding]; DNA binding site 941968003632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968003633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968003634 homodimer interface [polypeptide binding]; other site 941968003635 catalytic residue [active] 941968003641 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 941968003642 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941968003643 ATP binding site [chemical binding]; other site 941968003644 Mg++ binding site [ion binding]; other site 941968003645 motif III; other site 941968003646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968003647 nucleotide binding region [chemical binding]; other site 941968003648 ATP-binding site [chemical binding]; other site 941968003652 1 probable transmembrane helix predicted for cbot00708 by TMHMM2.0 at aa 21-43 941968003656 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 941968003657 diiron binding motif [ion binding]; other site 941968003660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968003661 MarR family; Region: MarR_2; pfam12802 941968003664 1 probable transmembrane helix predicted for cbot00710 by TMHMM2.0 at aa 58-80 941968003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968003666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968003667 putative substrate translocation pore; other site 941968003668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968003673 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 941968003674 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 941968003676 1 probable transmembrane helix predicted for cbot00712 by TMHMM2.0 at aa 29-46 941968003677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968003678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968003679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941968003680 dimerization interface [polypeptide binding]; other site 941968003681 1 probable transmembrane helix predicted for cbot00713 by TMHMM2.0 at aa 2-24 941968003684 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 941968003686 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 941968003687 1 probable transmembrane helix predicted for cbot00715 by TMHMM2.0 at aa 25-47 941968003689 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 941968003691 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 941968003693 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941968003694 putative active site [active] 941968003697 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 941968003698 PLD-like domain; Region: PLDc_2; pfam13091 941968003699 putative homodimer interface [polypeptide binding]; other site 941968003700 putative active site [active] 941968003701 catalytic site [active] 941968003702 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 941968003703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968003704 ATP binding site [chemical binding]; other site 941968003705 putative Mg++ binding site [ion binding]; other site 941968003706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968003707 nucleotide binding region [chemical binding]; other site 941968003708 ATP-binding site [chemical binding]; other site 941968003709 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 941968003715 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 941968003716 active site 941968003717 8-oxo-dGMP binding site [chemical binding]; other site 941968003718 nudix motif; other site 941968003719 metal binding site [ion binding]; metal-binding site 941968003722 transcriptional antiterminator BglG; Provisional; Region: PRK09772 941968003723 CAT RNA binding domain; Region: CAT_RBD; smart01061 941968003724 PRD domain; Region: PRD; pfam00874 941968003725 PRD domain; Region: PRD; pfam00874 941968003729 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 941968003730 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968003731 active site turn [active] 941968003732 phosphorylation site [posttranslational modification] 941968003733 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968003734 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968003735 HPr interaction site; other site 941968003736 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968003737 active site 941968003738 phosphorylation site [posttranslational modification] 941968003742 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 941968003743 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 941968003744 active site 941968003745 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 941968003748 potential frameshift: common BLAST hit: gi|170754966|ref|YP_001780295.1| Crp/FNR family transcriptional regulator 941968003749 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968003750 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968003752 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968003753 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941968003754 putative switch regulator; other site 941968003755 non-specific DNA interactions [nucleotide binding]; other site 941968003756 DNA binding site [nucleotide binding] 941968003757 sequence specific DNA binding site [nucleotide binding]; other site 941968003758 putative cAMP binding site [chemical binding]; other site 941968003761 potential frameshift: common BLAST hit: gi|384461084|ref|YP_005673679.1| metallo-beta-lactamase family protein 941968003762 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 941968003763 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968003764 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968003768 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 941968003769 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 941968003770 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 941968003776 Family of unknown function (DUF438); Region: DUF438; pfam04282 941968003777 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 941968003784 1 probable transmembrane helix predicted for cbot00732 by TMHMM2.0 at aa 15-37 941968003785 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968003788 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 941968003789 TM-ABC transporter signature motif; other site 941968003792 1 probable transmembrane helix predicted for cbot00734 by TMHMM2.0 at aa 5-27 941968003793 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 941968003794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968003795 Walker A/P-loop; other site 941968003796 ATP binding site [chemical binding]; other site 941968003797 Q-loop/lid; other site 941968003798 ABC transporter signature motif; other site 941968003799 Walker B; other site 941968003800 D-loop; other site 941968003801 H-loop/switch region; other site 941968003804 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 941968003805 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941968003806 zinc binding site [ion binding]; other site 941968003807 putative ligand binding site [chemical binding]; other site 941968003812 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 941968003813 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941968003814 FMN binding site [chemical binding]; other site 941968003815 active site 941968003816 catalytic residues [active] 941968003817 substrate binding site [chemical binding]; other site 941968003819 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941968003820 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941968003824 Outer spore coat protein E (CotE); Region: CotE; pfam10628 941968003826 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 941968003827 HsdM N-terminal domain; Region: HsdM_N; pfam12161 941968003828 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941968003834 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941968003835 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941968003836 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941968003840 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 941968003842 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 941968003843 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 941968003844 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 941968003845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968003846 ATP binding site [chemical binding]; other site 941968003847 putative Mg++ binding site [ion binding]; other site 941968003848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 941968003849 nucleotide binding region [chemical binding]; other site 941968003850 ATP-binding site [chemical binding]; other site 941968003857 TfoX C-terminal domain; Region: TfoX_C; pfam04994 941968003859 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 941968003862 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 941968003864 1 probable transmembrane helix predicted for cbot00749 by TMHMM2.0 at aa 29-51 941968003866 Penicillinase repressor; Region: Pencillinase_R; pfam03965 941968003868 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 941968003871 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 941968003872 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 941968003876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 941968003878 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968003879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968003880 1 probable transmembrane helix predicted for cbot00754 by TMHMM2.0 at aa 33-55 941968003883 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941968003884 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968003885 intersubunit interface [polypeptide binding]; other site 941968003888 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968003889 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968003890 ABC-ATPase subunit interface; other site 941968003891 dimer interface [polypeptide binding]; other site 941968003892 putative PBP binding regions; other site 941968003895 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968003896 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968003897 ABC-ATPase subunit interface; other site 941968003898 dimer interface [polypeptide binding]; other site 941968003899 putative PBP binding regions; other site 941968003902 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968003903 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968003904 Walker A/P-loop; other site 941968003905 ATP binding site [chemical binding]; other site 941968003906 Q-loop/lid; other site 941968003907 ABC transporter signature motif; other site 941968003908 Walker B; other site 941968003909 D-loop; other site 941968003910 H-loop/switch region; other site 941968003913 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968003914 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941968003916 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 941968003917 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 941968003920 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 941968003921 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 941968003924 Cache domain; Region: Cache_1; pfam02743 941968003925 HAMP domain; Region: HAMP; pfam00672 941968003926 dimerization interface [polypeptide binding]; other site 941968003927 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968003928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968003929 dimer interface [polypeptide binding]; other site 941968003930 putative CheW interface [polypeptide binding]; other site 941968003939 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968003940 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 941968003941 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 941968003942 1 probable transmembrane helix predicted for cbot00764 by TMHMM2.0 at aa 37-59 941968003945 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 941968003946 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 941968003947 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941968003951 glycine cleavage system protein H; Provisional; Region: PRK13380 941968003952 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941968003953 lipoyl attachment site [posttranslational modification]; other site 941968003955 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 941968003956 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941968003957 tetramer interface [polypeptide binding]; other site 941968003958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968003959 catalytic residue [active] 941968003962 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941968003963 tetramer interface [polypeptide binding]; other site 941968003964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968003965 catalytic residue [active] 941968003969 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 941968003970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968003971 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941968003976 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941968003977 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 941968003978 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 941968003982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 941968003984 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941968003985 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941968003986 DNA binding residues [nucleotide binding] 941968003987 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 941968003988 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968003989 DNA binding residues [nucleotide binding] 941968003990 dimer interface [polypeptide binding]; other site 941968003995 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941968003996 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968003997 Walker A/P-loop; other site 941968003998 ATP binding site [chemical binding]; other site 941968003999 Q-loop/lid; other site 941968004000 ABC transporter signature motif; other site 941968004001 Walker B; other site 941968004002 D-loop; other site 941968004003 H-loop/switch region; other site 941968004010 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941968004011 EamA-like transporter family; Region: EamA; pfam00892 941968004012 EamA-like transporter family; Region: EamA; pfam00892 941968004017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968004018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968004019 non-specific DNA binding site [nucleotide binding]; other site 941968004020 salt bridge; other site 941968004021 sequence-specific DNA binding site [nucleotide binding]; other site 941968004022 Cupin domain; Region: Cupin_2; pfam07883 941968004026 TfoX C-terminal domain; Region: TfoX_C; pfam04994 941968004028 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 941968004029 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941968004030 dimer interface [polypeptide binding]; other site 941968004031 active site 941968004032 CoA binding pocket [chemical binding]; other site 941968004036 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 941968004037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968004038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968004039 dimer interface [polypeptide binding]; other site 941968004040 putative CheW interface [polypeptide binding]; other site 941968004045 Mor transcription activator family; Region: Mor; cl02360 941968004047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941968004048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968004049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968004050 ABC transporter; Region: ABC_tran_2; pfam12848 941968004051 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968004057 Predicted transcriptional regulator [Transcription]; Region: COG2378 941968004058 HTH domain; Region: HTH_11; pfam08279 941968004059 WYL domain; Region: WYL; pfam13280 941968004062 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 941968004063 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 941968004064 conserved cys residue [active] 941968004066 1 probable transmembrane helix predicted for cbot00786 by TMHMM2.0 at aa 19-41 941968004068 1 probable transmembrane helix predicted for cbot00787 by TMHMM2.0 at aa 4-20 941968004069 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941968004070 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941968004071 dimer interface [polypeptide binding]; other site 941968004072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004073 catalytic residue [active] 941968004076 S-ribosylhomocysteinase; Provisional; Region: PRK02260 941968004078 cystathionine beta-lyase; Provisional; Region: PRK07671 941968004079 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941968004080 homodimer interface [polypeptide binding]; other site 941968004081 substrate-cofactor binding pocket; other site 941968004082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004083 catalytic residue [active] 941968004085 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941968004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968004087 S-adenosylmethionine binding site [chemical binding]; other site 941968004089 1 probable transmembrane helix predicted for cbot00791 by TMHMM2.0 at aa 77-94 941968004090 Glyco_18 domain; Region: Glyco_18; smart00636 941968004091 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 941968004092 active site 941968004093 Chitinase C; Region: ChiC; pfam06483 941968004097 1 probable transmembrane helix predicted for cbot00793 by TMHMM2.0 at aa 15-37 941968004100 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968004101 metal-binding site [ion binding] 941968004103 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 941968004106 Domain of unknown function (DUF955); Region: DUF955; pfam06114 941968004108 1 probable transmembrane helix predicted for cbot00797 by TMHMM2.0 at aa 28-50 941968004109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968004110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968004111 non-specific DNA binding site [nucleotide binding]; other site 941968004112 salt bridge; other site 941968004113 sequence-specific DNA binding site [nucleotide binding]; other site 941968004116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968004117 non-specific DNA binding site [nucleotide binding]; other site 941968004118 salt bridge; other site 941968004119 sequence-specific DNA binding site [nucleotide binding]; other site 941968004122 potential frameshift: common BLAST hit: gi|384461173|ref|YP_005673768.1| phage protein 941968004123 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 941968004125 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968004126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968004128 YvrJ protein family; Region: YvrJ; pfam12841 941968004129 1 probable transmembrane helix predicted for cbot00803 by TMHMM2.0 at aa 5-24 941968004130 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 941968004132 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 941968004134 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941968004135 amidase catalytic site [active] 941968004136 Zn binding residues [ion binding]; other site 941968004137 substrate binding site [chemical binding]; other site 941968004141 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 941968004142 Low molecular weight phosphatase family; Region: LMWPc; cl00105 941968004143 active site 941968004145 1 probable transmembrane helix predicted for cbot00807 by TMHMM2.0 at aa 7-29 941968004146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968004147 dimerization interface [polypeptide binding]; other site 941968004148 putative DNA binding site [nucleotide binding]; other site 941968004149 putative Zn2+ binding site [ion binding]; other site 941968004152 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 941968004154 1 probable transmembrane helix predicted for cbot00809 by TMHMM2.0 at aa 20-42 941968004155 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 941968004156 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 941968004157 P loop; other site 941968004158 Nucleotide binding site [chemical binding]; other site 941968004159 DTAP/Switch II; other site 941968004160 Switch I; other site 941968004161 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 941968004162 P loop; other site 941968004163 Nucleotide binding site [chemical binding]; other site 941968004164 DTAP/Switch II; other site 941968004165 Switch I; other site 941968004171 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 941968004172 arsenical-resistance protein; Region: acr3; TIGR00832 941968004174 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 941968004175 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 941968004177 1 probable transmembrane helix predicted for cbot00813 by TMHMM2.0 at aa 55-77 941968004178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968004179 dimerization interface [polypeptide binding]; other site 941968004180 putative DNA binding site [nucleotide binding]; other site 941968004181 putative Zn2+ binding site [ion binding]; other site 941968004184 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941968004185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968004186 S-adenosylmethionine binding site [chemical binding]; other site 941968004188 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 941968004189 catalytic core [active] 941968004191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968004192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968004194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968004195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968004196 Walker A/P-loop; other site 941968004197 ATP binding site [chemical binding]; other site 941968004198 Q-loop/lid; other site 941968004199 ABC transporter signature motif; other site 941968004200 Walker B; other site 941968004201 D-loop; other site 941968004202 H-loop/switch region; other site 941968004204 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 941968004206 1 probable transmembrane helix predicted for cbot00822 by TMHMM2.0 at aa 28-50 941968004207 potential frameshift: common BLAST hit: gi|153935631|ref|YP_001386700.1| thymidylate synthase 941968004208 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 941968004209 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 941968004210 dimerization interface [polypeptide binding]; other site 941968004211 active site 941968004213 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 941968004215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968004216 S-adenosylmethionine binding site [chemical binding]; other site 941968004217 1 probable transmembrane helix predicted for cbot00825 by TMHMM2.0 at aa 20-42 941968004219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941968004224 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941968004225 dimer interface [polypeptide binding]; other site 941968004226 substrate binding site [chemical binding]; other site 941968004227 ATP binding site [chemical binding]; other site 941968004229 1 probable transmembrane helix predicted for cbot00827 by TMHMM2.0 at aa 20-39 941968004230 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 941968004234 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968004235 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968004236 Walker A/P-loop; other site 941968004237 ATP binding site [chemical binding]; other site 941968004238 Q-loop/lid; other site 941968004239 ABC transporter signature motif; other site 941968004240 Walker B; other site 941968004241 D-loop; other site 941968004242 H-loop/switch region; other site 941968004245 potential frameshift: common BLAST hit: gi|226948068|ref|YP_002803159.1| AraC family transcriptional regulator 941968004246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968004247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968004251 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 941968004253 1 probable transmembrane helix predicted for cbot00833 by TMHMM2.0 at aa 10-32 941968004254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968004255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968004256 dimer interface [polypeptide binding]; other site 941968004257 phosphorylation site [posttranslational modification] 941968004258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968004259 ATP binding site [chemical binding]; other site 941968004260 Mg2+ binding site [ion binding]; other site 941968004261 G-X-G motif; other site 941968004262 1 probable transmembrane helix predicted for cbot00834 by TMHMM2.0 at aa 2-21 941968004267 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 941968004272 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968004273 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968004274 Walker A/P-loop; other site 941968004275 ATP binding site [chemical binding]; other site 941968004276 Q-loop/lid; other site 941968004277 ABC transporter signature motif; other site 941968004278 Walker B; other site 941968004279 D-loop; other site 941968004280 H-loop/switch region; other site 941968004284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968004285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968004286 FtsX-like permease family; Region: FtsX; pfam02687 941968004287 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968004288 FtsX-like permease family; Region: FtsX; pfam02687 941968004296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968004298 active site 941968004299 phosphorylation site [posttranslational modification] 941968004300 intermolecular recognition site; other site 941968004301 dimerization interface [polypeptide binding]; other site 941968004302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968004303 DNA binding site [nucleotide binding] 941968004307 1 probable transmembrane helix predicted for cbot00840 by TMHMM2.0 at aa 66-88 941968004310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968004311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968004312 dimer interface [polypeptide binding]; other site 941968004313 phosphorylation site [posttranslational modification] 941968004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968004315 ATP binding site [chemical binding]; other site 941968004316 Mg2+ binding site [ion binding]; other site 941968004317 G-X-G motif; other site 941968004323 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 941968004325 Small acid-soluble spore protein H family; Region: SspH; pfam08141 941968004327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941968004328 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941968004329 Probable transposase; Region: OrfB_IS605; pfam01385 941968004330 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941968004334 1 probable transmembrane helix predicted for cbot00844 by TMHMM2.0 at aa 3-25 941968004340 dihydrodipicolinate reductase; Provisional; Region: PRK00048 941968004341 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 941968004342 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 941968004344 1 probable transmembrane helix predicted for cbot00846 by TMHMM2.0 at aa 27-49 941968004346 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941968004347 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 941968004348 active site residue [active] 941968004349 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941968004350 active site residue [active] 941968004356 1 probable transmembrane helix predicted for cbot00850 by TMHMM2.0 at aa 34-56 941968004358 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968004359 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 941968004363 Clostridium enterotoxin; Region: Clenterotox; pfam03505 941968004364 Clostridium enterotoxin; Region: Clenterotox; pfam03505 941968004367 Clostridium botulinum HA-17 protein; Region: Botulinum_HA-17; pfam05588 941968004369 Ricin-type beta-trefoil; Region: RICIN; smart00458 941968004370 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 941968004371 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 941968004372 Ricin-type beta-trefoil; Region: RICIN; smart00458 941968004373 putative sugar binding sites [chemical binding]; other site 941968004374 Q-X-W motif; other site 941968004378 1 probable transmembrane helix predicted for cbot00859 by TMHMM2.0 at aa 7-29 941968004379 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 941968004380 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941968004381 DNA binding residues [nucleotide binding] 941968004382 1 probable transmembrane helix predicted for cbot00860 by TMHMM2.0 at aa 7-29 941968004384 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 941968004385 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 941968004386 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 941968004393 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 941968004394 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 941968004395 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 941968004396 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 941968004401 HTH-like domain; Region: HTH_21; pfam13276 941968004402 Integrase core domain; Region: rve; pfam00665 941968004403 Integrase core domain; Region: rve_2; pfam13333 941968004405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 941968004406 Transposase; Region: HTH_Tnp_1; pfam01527 941968004409 1 probable transmembrane helix predicted for cbot00867 by TMHMM2.0 at aa 12-34 941968004410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 941968004411 HTH-like domain; Region: HTH_21; pfam13276 941968004412 Integrase core domain; Region: rve; pfam00665 941968004413 Integrase core domain; Region: rve_3; pfam13683 941968004421 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 941968004424 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 941968004425 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 941968004426 active site 941968004430 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 941968004434 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 941968004439 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968004440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968004441 dimer interface [polypeptide binding]; other site 941968004442 putative CheW interface [polypeptide binding]; other site 941968004443 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 941968004444 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 941968004450 FeoA domain; Region: FeoA; pfam04023 941968004453 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 941968004454 GTP/Mg2+ binding site [chemical binding]; other site 941968004455 G5 box; other site 941968004456 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 941968004457 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 941968004458 G1 box; other site 941968004459 G1 box; other site 941968004460 GTP/Mg2+ binding site [chemical binding]; other site 941968004461 Switch I region; other site 941968004462 G2 box; other site 941968004463 G3 box; other site 941968004464 Switch II region; other site 941968004465 G4 box; other site 941968004466 G5 box; other site 941968004468 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 941968004469 Nucleoside recognition; Region: Gate; pfam07670 941968004470 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 941968004475 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941968004476 catalytic core [active] 941968004479 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 941968004480 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941968004481 VanW like protein; Region: VanW; pfam04294 941968004482 G5 domain; Region: G5; pfam07501 941968004488 cobalamin synthase; Reviewed; Region: cobS; PRK00235 941968004490 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 941968004494 1 probable transmembrane helix predicted for cbot00883 by TMHMM2.0 at aa 7-29 941968004495 Coat F domain; Region: Coat_F; pfam07875 941968004497 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 941968004498 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 941968004499 NodB motif; other site 941968004500 putative active site [active] 941968004501 putative catalytic site [active] 941968004502 putative Zn binding site [ion binding]; other site 941968004508 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 941968004509 active site 941968004511 1 probable transmembrane helix predicted for cbot00888 by TMHMM2.0 at aa 15-37 941968004512 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 941968004513 dihydropteroate synthase; Region: DHPS; TIGR01496 941968004514 substrate binding pocket [chemical binding]; other site 941968004515 dimer interface [polypeptide binding]; other site 941968004516 inhibitor binding site; inhibition site 941968004521 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 941968004522 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 941968004523 catalytic center binding site [active] 941968004524 ATP binding site [chemical binding]; other site 941968004526 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941968004527 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 941968004528 putative dimer interface [polypeptide binding]; other site 941968004530 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 941968004531 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968004532 DNA binding residues [nucleotide binding] 941968004533 dimer interface [polypeptide binding]; other site 941968004534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968004535 S-adenosylmethionine binding site [chemical binding]; other site 941968004540 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941968004541 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941968004542 inhibitor-cofactor binding pocket; inhibition site 941968004543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004544 catalytic residue [active] 941968004548 potential frameshift: common BLAST hit: gi|226948112|ref|YP_002803203.1| putative pleiotropic regulatory protein 941968004549 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941968004550 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941968004551 inhibitor-cofactor binding pocket; inhibition site 941968004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004553 catalytic residue [active] 941968004555 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941968004556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968004559 1 probable transmembrane helix predicted for cbot00896 by TMHMM2.0 at aa 15-37 941968004560 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941968004563 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 941968004564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968004565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968004566 DNA binding residues [nucleotide binding] 941968004570 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 941968004571 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 941968004575 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 941968004576 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 941968004578 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 941968004579 Cadmium resistance transporter; Region: Cad; pfam03596 941968004582 Protein of unknown function (DUF523); Region: DUF523; pfam04463 941968004584 Uncharacterized conserved protein [Function unknown]; Region: COG2128 941968004585 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941968004586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968004587 putative DNA binding site [nucleotide binding]; other site 941968004588 putative Zn2+ binding site [ion binding]; other site 941968004589 AsnC family; Region: AsnC_trans_reg; pfam01037 941968004593 1 probable transmembrane helix predicted for cbot00907 by TMHMM2.0 at aa 7-29 941968004596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968004597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968004598 active site 941968004599 phosphorylation site [posttranslational modification] 941968004600 intermolecular recognition site; other site 941968004601 dimerization interface [polypeptide binding]; other site 941968004602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968004603 DNA binding site [nucleotide binding] 941968004608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968004609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968004610 dimerization interface [polypeptide binding]; other site 941968004611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968004612 dimer interface [polypeptide binding]; other site 941968004613 phosphorylation site [posttranslational modification] 941968004614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968004615 ATP binding site [chemical binding]; other site 941968004616 Mg2+ binding site [ion binding]; other site 941968004617 G-X-G motif; other site 941968004624 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941968004625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968004626 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968004627 Walker A/P-loop; other site 941968004628 ATP binding site [chemical binding]; other site 941968004629 Q-loop/lid; other site 941968004630 ABC transporter signature motif; other site 941968004631 Walker B; other site 941968004632 D-loop; other site 941968004633 H-loop/switch region; other site 941968004636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968004637 non-specific DNA binding site [nucleotide binding]; other site 941968004638 salt bridge; other site 941968004639 sequence-specific DNA binding site [nucleotide binding]; other site 941968004643 TIGR04076 family protein; Region: TIGR04076 941968004646 1 probable transmembrane helix predicted for cbot00914 by TMHMM2.0 at aa 27-49 941968004649 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968004650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941968004651 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 941968004652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941968004654 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 941968004657 potential frameshift: common BLAST hit: gi|226948125|ref|YP_002803216.1| flavin reductase 941968004658 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968004659 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968004661 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968004662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968004663 dimerization interface [polypeptide binding]; other site 941968004664 putative DNA binding site [nucleotide binding]; other site 941968004665 putative Zn2+ binding site [ion binding]; other site 941968004668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941968004669 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 941968004670 DNA binding residues [nucleotide binding] 941968004671 dimer interface [polypeptide binding]; other site 941968004674 1 probable transmembrane helix predicted for cbot00922 by TMHMM2.0 at aa 21-43 941968004675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968004676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941968004677 Coenzyme A binding pocket [chemical binding]; other site 941968004679 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 941968004681 1 probable transmembrane helix predicted for cbot00925 by TMHMM2.0 at aa 37-59 941968004682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968004683 Coenzyme A binding pocket [chemical binding]; other site 941968004686 Pirin-related protein [General function prediction only]; Region: COG1741 941968004687 Pirin; Region: Pirin; pfam02678 941968004689 Predicted transcriptional regulators [Transcription]; Region: COG1733 941968004690 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941968004692 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 941968004693 dimer interface [polypeptide binding]; other site 941968004694 FMN binding site [chemical binding]; other site 941968004696 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 941968004700 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 941968004701 Cupin; Region: Cupin_1; smart00835 941968004702 Cupin; Region: Cupin_1; smart00835 941968004707 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 941968004710 Protein of unknown function, DUF606; Region: DUF606; pfam04657 941968004713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968004714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968004715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941968004716 dimerization interface [polypeptide binding]; other site 941968004719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941968004720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968004721 Coenzyme A binding pocket [chemical binding]; other site 941968004723 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 941968004724 Protein of unknown function, DUF606; Region: DUF606; pfam04657 941968004726 Protein of unknown function, DUF606; Region: DUF606; pfam04657 941968004728 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968004729 ligand binding site [chemical binding]; other site 941968004731 Predicted transcriptional regulator [Transcription]; Region: COG2378 941968004732 HTH domain; Region: HTH_11; pfam08279 941968004733 WYL domain; Region: WYL; pfam13280 941968004736 1 probable transmembrane helix predicted for cbot00940 by TMHMM2.0 at aa 10-32 941968004737 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 941968004740 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 941968004742 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941968004743 DNA binding residues [nucleotide binding] 941968004744 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941968004745 active site 941968004746 catalytic residues [active] 941968004747 metal binding site [ion binding]; metal-binding site 941968004749 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968004750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968004751 DNA-binding site [nucleotide binding]; DNA binding site 941968004752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968004753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004754 homodimer interface [polypeptide binding]; other site 941968004755 catalytic residue [active] 941968004759 potential frameshift: common BLAST hit: gi|153941009|ref|YP_001390226.1| AraC family transcriptional regulator 941968004760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968004761 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968004762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968004763 1 probable transmembrane helix predicted for cbot00946 by TMHMM2.0 at aa 2-24 941968004767 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 941968004768 putative FMN binding site [chemical binding]; other site 941968004770 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 941968004771 transcriptional antiterminator BglG; Provisional; Region: PRK09772 941968004772 CAT RNA binding domain; Region: CAT_RBD; smart01061 941968004773 PRD domain; Region: PRD; pfam00874 941968004774 PRD domain; Region: PRD; pfam00874 941968004777 1 probable transmembrane helix predicted for cbot00950 by TMHMM2.0 at aa 2-24 941968004780 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 941968004781 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968004782 active site turn [active] 941968004783 phosphorylation site [posttranslational modification] 941968004784 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968004785 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968004786 HPr interaction site; other site 941968004787 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968004788 active site 941968004789 phosphorylation site [posttranslational modification] 941968004796 beta-galactosidase; Region: BGL; TIGR03356 941968004797 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 941968004799 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 941968004800 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 941968004801 Mg++ binding site [ion binding]; other site 941968004802 putative catalytic motif [active] 941968004803 putative substrate binding site [chemical binding]; other site 941968004807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968004808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968004809 non-specific DNA binding site [nucleotide binding]; other site 941968004810 sequence-specific DNA binding site [nucleotide binding]; other site 941968004811 salt bridge; other site 941968004814 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 941968004815 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 941968004816 trimer interface [polypeptide binding]; other site 941968004817 active site 941968004818 substrate binding site [chemical binding]; other site 941968004819 CoA binding site [chemical binding]; other site 941968004821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 941968004822 1 probable transmembrane helix predicted for cbot00958 by TMHMM2.0 at aa 20-42 941968004825 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 941968004827 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968004829 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 941968004830 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 941968004833 1 probable transmembrane helix predicted for cbot00963 by TMHMM2.0 at aa 21-43 941968004836 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941968004837 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 941968004840 Predicted membrane protein [Function unknown]; Region: COG2510 941968004841 Predicted membrane protein [Function unknown]; Region: COG2510 941968004845 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 941968004847 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 941968004849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941968004850 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941968004852 YmaF family; Region: YmaF; pfam12788 941968004853 1 probable transmembrane helix predicted for cbot00970 by TMHMM2.0 at aa 42-64 941968004855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941968004856 1 probable transmembrane helix predicted for cbot00971 by TMHMM2.0 at aa 5-24 941968004859 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968004860 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968004861 Walker A/P-loop; other site 941968004862 ATP binding site [chemical binding]; other site 941968004863 Q-loop/lid; other site 941968004864 ABC transporter signature motif; other site 941968004865 Walker B; other site 941968004866 D-loop; other site 941968004867 H-loop/switch region; other site 941968004868 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 941968004869 FtsX-like permease family; Region: FtsX; pfam02687 941968004873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941968004874 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941968004875 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941968004877 1 probable transmembrane helix predicted for cbot00975 by TMHMM2.0 at aa 13-35 941968004880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968004881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968004882 active site 941968004883 phosphorylation site [posttranslational modification] 941968004884 intermolecular recognition site; other site 941968004885 dimerization interface [polypeptide binding]; other site 941968004886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968004887 DNA binding site [nucleotide binding] 941968004892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968004893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968004894 dimerization interface [polypeptide binding]; other site 941968004895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968004896 dimer interface [polypeptide binding]; other site 941968004897 phosphorylation site [posttranslational modification] 941968004898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968004899 ATP binding site [chemical binding]; other site 941968004900 Mg2+ binding site [ion binding]; other site 941968004901 G-X-G motif; other site 941968004909 BioY family; Region: BioY; pfam02632 941968004913 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 941968004914 Sel1 repeat; Region: Sel1; pfam08238 941968004915 Sel1-like repeats; Region: SEL1; smart00671 941968004916 Sel1-like repeats; Region: SEL1; smart00671 941968004917 Sel1-like repeats; Region: SEL1; smart00671 941968004926 putative acetyltransferase YhhY; Provisional; Region: PRK10140 941968004927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968004928 Coenzyme A binding pocket [chemical binding]; other site 941968004930 potential frameshift: common BLAST hit: gi|384461340|ref|YP_005673935.1| LexA repressor 941968004931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941968004932 ATP binding site [chemical binding]; other site 941968004933 putative Mg++ binding site [ion binding]; other site 941968004934 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 941968004935 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941968004936 Catalytic site [active] 941968004942 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 941968004943 homotrimer interface [polypeptide binding]; other site 941968004944 Walker A motif; other site 941968004945 GTP binding site [chemical binding]; other site 941968004946 Walker B motif; other site 941968004948 1 probable transmembrane helix predicted for cbot00983 by TMHMM2.0 at aa 38-60 941968004949 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 941968004950 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968004951 DNA binding residues [nucleotide binding] 941968004952 dimer interface [polypeptide binding]; other site 941968004953 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 941968004958 cobyric acid synthase; Provisional; Region: PRK00784 941968004959 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968004960 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968004961 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 941968004962 catalytic triad [active] 941968004969 potential frameshift: common BLAST hit: gi|226948187|ref|YP_002803278.1| cobalamin biosynthesis protein 941968004970 CobD/Cbib protein; Region: CobD_Cbib; cl00561 941968004972 1 probable transmembrane helix predicted for cbot00986 by TMHMM2.0 at aa 58-80 941968004973 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 941968004975 potential frameshift: common BLAST hit: gi|170756649|ref|YP_001780548.1| aminotransferase 941968004976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968004977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968004978 homodimer interface [polypeptide binding]; other site 941968004979 catalytic residue [active] 941968004981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968004982 cobalt transport protein CbiM; Validated; Region: PRK08319 941968004983 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 941968004986 cobalt transport protein CbiN; Provisional; Region: PRK02898 941968004989 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 941968004992 1 probable transmembrane helix predicted for cbot00993 by TMHMM2.0 at aa 15-37 941968004994 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941968004995 active site 941968004996 SAM binding site [chemical binding]; other site 941968004997 homodimer interface [polypeptide binding]; other site 941968004998 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 941968004999 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 941968005000 active site 941968005004 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 941968005005 dimer interface [polypeptide binding]; other site 941968005006 active site 941968005007 Schiff base residues; other site 941968005009 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 941968005010 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 941968005011 catalytic triad [active] 941968005017 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 941968005018 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 941968005022 Predicted ATPase [General function prediction only]; Region: COG3910 941968005023 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 941968005024 Walker A/P-loop; other site 941968005025 ATP binding site [chemical binding]; other site 941968005026 Q-loop/lid; other site 941968005027 ABC transporter signature motif; other site 941968005028 Walker B; other site 941968005029 D-loop; other site 941968005030 H-loop/switch region; other site 941968005032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941968005034 Coenzyme A binding pocket [chemical binding]; other site 941968005036 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 941968005037 FMN binding site [chemical binding]; other site 941968005038 dimer interface [polypeptide binding]; other site 941968005042 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 941968005046 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 941968005047 active site 941968005048 putative homodimer interface [polypeptide binding]; other site 941968005049 SAM binding site [chemical binding]; other site 941968005051 1 probable transmembrane helix predicted for cbot01006 by TMHMM2.0 at aa 15-37 941968005052 SdpI/YhfL protein family; Region: SdpI; pfam13630 941968005053 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 941968005054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968005055 S-adenosylmethionine binding site [chemical binding]; other site 941968005058 hypothetical protein; Provisional; Region: PRK06771 941968005061 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968005062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005063 Coenzyme A binding pocket [chemical binding]; other site 941968005064 1 probable transmembrane helix predicted for cbot01014 by TMHMM2.0 at aa 15-37 941968005066 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 941968005067 active site 941968005068 SAM binding site [chemical binding]; other site 941968005069 homodimer interface [polypeptide binding]; other site 941968005071 1 probable transmembrane helix predicted for cbot01016 by TMHMM2.0 at aa 20-42 941968005073 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 941968005074 active site 941968005075 SAM binding site [chemical binding]; other site 941968005076 homodimer interface [polypeptide binding]; other site 941968005079 potential frameshift: common BLAST hit: gi|384461377|ref|YP_005673972.1| cobalamin biosynthesis protein CbiG 941968005080 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 941968005081 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 941968005082 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 941968005083 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 941968005089 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 941968005090 active site 941968005091 SAM binding site [chemical binding]; other site 941968005092 homodimer interface [polypeptide binding]; other site 941968005094 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 941968005095 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 941968005097 1 probable transmembrane helix predicted for cbot01021 by TMHMM2.0 at aa 52-74 941968005098 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 941968005101 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 941968005102 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 941968005103 active site 941968005104 C-terminal domain interface [polypeptide binding]; other site 941968005105 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 941968005106 active site 941968005107 N-terminal domain interface [polypeptide binding]; other site 941968005109 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 941968005110 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941968005113 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 941968005114 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 941968005115 homodimer interface [polypeptide binding]; other site 941968005116 Walker A motif; other site 941968005117 ATP binding site [chemical binding]; other site 941968005118 hydroxycobalamin binding site [chemical binding]; other site 941968005119 Walker B motif; other site 941968005122 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968005123 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968005124 ligand binding site [chemical binding]; other site 941968005125 flexible hinge region; other site 941968005126 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941968005127 putative switch regulator; other site 941968005128 non-specific DNA interactions [nucleotide binding]; other site 941968005129 DNA binding site [nucleotide binding] 941968005130 sequence specific DNA binding site [nucleotide binding]; other site 941968005131 putative cAMP binding site [chemical binding]; other site 941968005136 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 941968005138 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 941968005139 1 probable transmembrane helix predicted for cbot01029 by TMHMM2.0 at aa 36-58 941968005140 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 941968005141 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 941968005142 FAD binding pocket [chemical binding]; other site 941968005143 FAD binding motif [chemical binding]; other site 941968005144 phosphate binding motif [ion binding]; other site 941968005145 beta-alpha-beta structure motif; other site 941968005146 NAD binding pocket [chemical binding]; other site 941968005147 Iron coordination center [ion binding]; other site 941968005151 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 941968005152 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941968005153 4Fe-4S binding domain; Region: Fer4; pfam00037 941968005158 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 941968005159 putative MPT binding site; other site 941968005164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968005165 ABC transporter; Region: ABC_tran; pfam00005 941968005166 Q-loop/lid; other site 941968005167 ABC transporter signature motif; other site 941968005168 Walker B; other site 941968005169 D-loop; other site 941968005170 H-loop/switch region; other site 941968005175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968005176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968005177 active site 941968005178 phosphorylation site [posttranslational modification] 941968005179 intermolecular recognition site; other site 941968005180 dimerization interface [polypeptide binding]; other site 941968005181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968005182 DNA binding site [nucleotide binding] 941968005187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968005188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968005189 dimer interface [polypeptide binding]; other site 941968005190 phosphorylation site [posttranslational modification] 941968005191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968005192 ATP binding site [chemical binding]; other site 941968005193 G-X-G motif; other site 941968005199 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968005200 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968005201 Walker A/P-loop; other site 941968005202 ATP binding site [chemical binding]; other site 941968005203 Q-loop/lid; other site 941968005204 ABC transporter signature motif; other site 941968005205 Walker B; other site 941968005206 D-loop; other site 941968005207 H-loop/switch region; other site 941968005211 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968005212 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968005213 ABC-ATPase subunit interface; other site 941968005214 dimer interface [polypeptide binding]; other site 941968005215 putative PBP binding regions; other site 941968005219 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 941968005220 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 941968005221 putative ligand binding residues [chemical binding]; other site 941968005226 HTH domain; Region: HTH_11; pfam08279 941968005227 WYL domain; Region: WYL; pfam13280 941968005230 1 probable transmembrane helix predicted for cbot01045 by TMHMM2.0 at aa 10-32 941968005231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968005232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968005233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941968005234 dimerization interface [polypeptide binding]; other site 941968005237 threonine synthase; Validated; Region: PRK06260 941968005238 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 941968005239 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968005240 catalytic residue [active] 941968005242 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941968005244 dihydroxyacetone kinase; Provisional; Region: PRK14479 941968005245 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 941968005246 DAK2 domain; Region: Dak2; pfam02734 941968005254 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 941968005255 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 941968005256 dimer interface [polypeptide binding]; other site 941968005257 active site 941968005258 metal binding site [ion binding]; metal-binding site 941968005260 1 probable transmembrane helix predicted for cbot01050 by TMHMM2.0 at aa 24-46 941968005262 Sensory domain found in PocR; Region: PocR; pfam10114 941968005263 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 941968005264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968005265 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968005266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968005271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941968005272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005273 Coenzyme A binding pocket [chemical binding]; other site 941968005275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005276 Coenzyme A binding pocket [chemical binding]; other site 941968005279 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 941968005281 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 941968005282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941968005283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941968005284 active site 941968005285 catalytic tetrad [active] 941968005287 1 probable transmembrane helix predicted for cbot01056 by TMHMM2.0 at aa 27-49 941968005288 TfoX N-terminal domain; Region: TfoX_N; pfam04993 941968005290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941968005291 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941968005292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005293 Coenzyme A binding pocket [chemical binding]; other site 941968005296 1 probable transmembrane helix predicted for cbot01059 by TMHMM2.0 at aa 25-47 941968005297 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 941968005300 VanZ like family; Region: VanZ; pfam04892 941968005302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968005303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968005304 dimer interface [polypeptide binding]; other site 941968005305 phosphorylation site [posttranslational modification] 941968005306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968005307 ATP binding site [chemical binding]; other site 941968005308 Mg2+ binding site [ion binding]; other site 941968005309 G-X-G motif; other site 941968005314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968005315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968005316 active site 941968005317 phosphorylation site [posttranslational modification] 941968005318 intermolecular recognition site; other site 941968005319 dimerization interface [polypeptide binding]; other site 941968005320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968005321 DNA binding site [nucleotide binding] 941968005326 1 probable transmembrane helix predicted for cbot01064 by TMHMM2.0 at aa 23-45 941968005327 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 941968005329 1 probable transmembrane helix predicted for cbot01065 by TMHMM2.0 at aa 43-65 941968005330 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 941968005331 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 941968005332 active site 941968005333 purine riboside binding site [chemical binding]; other site 941968005335 1 probable transmembrane helix predicted for cbot01066 by TMHMM2.0 at aa 26-48 941968005337 Predicted membrane protein [Function unknown]; Region: COG1511 941968005338 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941968005339 Predicted membrane protein [Function unknown]; Region: COG1511 941968005340 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941968005342 Predicted membrane protein [Function unknown]; Region: COG1511 941968005343 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941968005344 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941968005348 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 941968005349 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 941968005350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968005351 ATP binding site [chemical binding]; other site 941968005352 putative Mg++ binding site [ion binding]; other site 941968005353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968005354 nucleotide binding region [chemical binding]; other site 941968005355 ATP-binding site [chemical binding]; other site 941968005356 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 941968005357 HRDC domain; Region: HRDC; pfam00570 941968005365 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 941968005366 Rubrerythrin [Energy production and conversion]; Region: COG1592 941968005367 diiron binding motif [ion binding]; other site 941968005370 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 941968005371 active site 941968005372 metal binding site [ion binding]; metal-binding site 941968005373 homotetramer interface [polypeptide binding]; other site 941968005375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 941968005376 active site 941968005377 phosphorylation site [posttranslational modification] 941968005378 intermolecular recognition site; other site 941968005380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968005381 TPR repeat; Region: TPR_11; pfam13414 941968005382 TPR motif; other site 941968005383 binding surface 941968005384 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 941968005387 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 941968005389 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 941968005390 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 941968005392 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 941968005393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968005394 FeS/SAM binding site; other site 941968005396 Ycf46; Provisional; Region: ycf46; CHL00195 941968005397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968005398 Walker A motif; other site 941968005399 ATP binding site [chemical binding]; other site 941968005400 Walker B motif; other site 941968005401 arginine finger; other site 941968005405 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 941968005406 L-lactate permease; Region: Lactate_perm; cl00701 941968005410 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 941968005412 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941968005413 Ligand binding site [chemical binding]; other site 941968005414 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941968005417 1 probable transmembrane helix predicted for cbot01083 by TMHMM2.0 at aa 15-37 941968005420 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 941968005421 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941968005422 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941968005423 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941968005429 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 941968005430 FAD binding domain; Region: FAD_binding_4; pfam01565 941968005438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968005441 Putative cyclase; Region: Cyclase; pfam04199 941968005443 aspartate aminotransferase; Provisional; Region: PRK06836 941968005444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968005445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968005446 homodimer interface [polypeptide binding]; other site 941968005447 catalytic residue [active] 941968005449 1 probable transmembrane helix predicted for cbot01090 by TMHMM2.0 at aa 21-43 941968005450 Putative cyclase; Region: Cyclase; pfam04199 941968005451 Putative cyclase; Region: Cyclase; cl00814 941968005452 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 941968005455 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 941968005458 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 941968005459 B3/4 domain; Region: B3_4; pfam03483 941968005462 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 941968005463 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 941968005464 Dimer interface [polypeptide binding]; other site 941968005465 anticodon binding site; other site 941968005466 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 941968005467 homodimer interface [polypeptide binding]; other site 941968005468 motif 1; other site 941968005469 motif 2; other site 941968005470 active site 941968005471 motif 3; other site 941968005474 1 probable transmembrane helix predicted for cbot01096 by TMHMM2.0 at aa 15-37 941968005476 flavodoxin; Provisional; Region: PRK06242 941968005478 1 probable transmembrane helix predicted for cbot01097 by TMHMM2.0 at aa 12-30 941968005479 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 941968005481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968005482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968005483 WHG domain; Region: WHG; pfam13305 941968005485 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 941968005486 dUMP phosphatase; Provisional; Region: PRK09449 941968005487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968005488 motif II; other site 941968005490 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 941968005491 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968005492 ligand binding site [chemical binding]; other site 941968005493 flexible hinge region; other site 941968005494 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941968005495 putative switch regulator; other site 941968005496 DNA binding site [nucleotide binding] 941968005497 sequence specific DNA binding site [nucleotide binding]; other site 941968005498 putative cAMP binding site [chemical binding]; other site 941968005500 DJ-1 family protein; Region: not_thiJ; TIGR01383 941968005501 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 941968005502 conserved cys residue [active] 941968005505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968005506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968005507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941968005508 dimerization interface [polypeptide binding]; other site 941968005511 YoaP-like; Region: YoaP; pfam14268 941968005512 FeoA domain; Region: FeoA; pfam04023 941968005514 1 probable transmembrane helix predicted for cbot01106 by TMHMM2.0 at aa 2-24 941968005515 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 941968005518 1 probable transmembrane helix predicted for cbot01107 by TMHMM2.0 at aa 21-43 941968005519 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 941968005520 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 941968005521 G1 box; other site 941968005522 GTP/Mg2+ binding site [chemical binding]; other site 941968005523 Switch I region; other site 941968005524 G2 box; other site 941968005525 G3 box; other site 941968005526 Switch II region; other site 941968005527 G4 box; other site 941968005528 G5 box; other site 941968005529 Nucleoside recognition; Region: Gate; pfam07670 941968005530 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 941968005531 Nucleoside recognition; Region: Gate; pfam07670 941968005540 Predicted membrane protein [Function unknown]; Region: COG2323 941968005543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941968005544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005545 Coenzyme A binding pocket [chemical binding]; other site 941968005547 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 941968005548 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 941968005552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968005553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968005554 active site 941968005555 phosphorylation site [posttranslational modification] 941968005556 intermolecular recognition site; other site 941968005557 dimerization interface [polypeptide binding]; other site 941968005558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968005559 DNA binding site [nucleotide binding] 941968005562 1 probable transmembrane helix predicted for cbot01113 by TMHMM2.0 at aa 21-43 941968005564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968005565 dimer interface [polypeptide binding]; other site 941968005566 phosphorylation site [posttranslational modification] 941968005567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968005568 ATP binding site [chemical binding]; other site 941968005569 Mg2+ binding site [ion binding]; other site 941968005570 G-X-G motif; other site 941968005578 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 941968005579 Cytochrome P450; Region: p450; cl12078 941968005580 Cytochrome P450; Region: p450; cl12078 941968005584 potential frameshift: common BLAST hit: gi|153937556|ref|YP_001386958.1| heavy metal-binding domain-containing protein 941968005585 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 941968005586 Family description; Region: DsbD_2; pfam13386 941968005587 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 941968005588 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 941968005590 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968005591 metal-binding site [ion binding] 941968005594 Predicted membrane protein [Function unknown]; Region: COG3462 941968005595 Short C-terminal domain; Region: SHOCT; pfam09851 941968005597 1 probable transmembrane helix predicted for cbot01120 by TMHMM2.0 at aa 15-37 941968005598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968005599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968005600 active site 941968005601 phosphorylation site [posttranslational modification] 941968005602 intermolecular recognition site; other site 941968005603 dimerization interface [polypeptide binding]; other site 941968005604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968005605 DNA binding site [nucleotide binding] 941968005608 1 probable transmembrane helix predicted for cbot01121 by TMHMM2.0 at aa 24-46 941968005610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968005611 HAMP domain; Region: HAMP; pfam00672 941968005612 dimerization interface [polypeptide binding]; other site 941968005613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968005614 dimer interface [polypeptide binding]; other site 941968005615 phosphorylation site [posttranslational modification] 941968005616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968005617 ATP binding site [chemical binding]; other site 941968005618 Mg2+ binding site [ion binding]; other site 941968005619 G-X-G motif; other site 941968005627 A new structural DNA glycosylase; Region: AlkD_like; cd06561 941968005628 active site 941968005630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968005631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968005632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968005636 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968005637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968005638 ABC-ATPase subunit interface; other site 941968005639 dimer interface [polypeptide binding]; other site 941968005640 putative PBP binding regions; other site 941968005642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968005643 ABC-ATPase subunit interface; other site 941968005644 dimer interface [polypeptide binding]; other site 941968005645 putative PBP binding regions; other site 941968005648 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 941968005649 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968005650 Walker A/P-loop; other site 941968005651 ATP binding site [chemical binding]; other site 941968005652 Q-loop/lid; other site 941968005653 ABC transporter signature motif; other site 941968005654 Walker B; other site 941968005655 D-loop; other site 941968005656 H-loop/switch region; other site 941968005660 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 941968005661 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 941968005662 putative ligand binding residues [chemical binding]; other site 941968005666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968005667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968005668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968005669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968005670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968005671 Walker A/P-loop; other site 941968005672 ATP binding site [chemical binding]; other site 941968005673 Q-loop/lid; other site 941968005674 ABC transporter signature motif; other site 941968005675 Walker B; other site 941968005676 D-loop; other site 941968005677 H-loop/switch region; other site 941968005683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968005684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968005685 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 941968005686 Walker A/P-loop; other site 941968005687 ATP binding site [chemical binding]; other site 941968005688 Q-loop/lid; other site 941968005689 ABC transporter signature motif; other site 941968005690 Walker B; other site 941968005691 D-loop; other site 941968005692 H-loop/switch region; other site 941968005701 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 941968005702 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 941968005704 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941968005705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968005706 active site 941968005707 phosphorylation site [posttranslational modification] 941968005708 intermolecular recognition site; other site 941968005709 dimerization interface [polypeptide binding]; other site 941968005710 LytTr DNA-binding domain; Region: LytTR; smart00850 941968005716 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968005717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968005719 potential frameshift: common BLAST hit: gi|153936807|ref|YP_001386975.1| BNR/Asp-box repeat-containing protein 941968005720 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 941968005723 conserved repeat domain; Region: B_ant_repeat; TIGR01451 941968005724 Domain of unknown function DUF11; Region: DUF11; pfam01345 941968005725 Domain of unknown function DUF11; Region: DUF11; cl17728 941968005726 Domain of unknown function DUF11; Region: DUF11; pfam01345 941968005739 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 941968005740 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 941968005741 putative active site [active] 941968005742 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 941968005743 Interdomain contacts; other site 941968005744 Cytokine receptor motif; other site 941968005745 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 941968005748 1 probable transmembrane helix predicted for cbot01138 by TMHMM2.0 at aa 7-29 941968005754 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 941968005755 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 941968005756 catalytic residues [active] 941968005757 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 941968005759 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 941968005760 Predicted membrane protein [Function unknown]; Region: COG4129 941968005761 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 941968005762 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 941968005766 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 941968005769 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 941968005772 1 probable transmembrane helix predicted for cbot01144 by TMHMM2.0 at aa 5-27 941968005773 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941968005774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968005775 Walker A/P-loop; other site 941968005776 ATP binding site [chemical binding]; other site 941968005777 ABC transporter signature motif; other site 941968005778 Walker B; other site 941968005779 D-loop; other site 941968005780 H-loop/switch region; other site 941968005781 ABC transporter; Region: ABC_tran_2; pfam12848 941968005782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968005790 Nucleoside recognition; Region: Gate; pfam07670 941968005792 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 941968005793 ArsC family; Region: ArsC; pfam03960 941968005794 catalytic residue [active] 941968005796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968005797 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 941968005798 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 941968005799 1 probable transmembrane helix predicted for cbot01148 by TMHMM2.0 at aa 67-89 941968005800 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941968005801 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941968005802 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941968005808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968005809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941968005813 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 941968005814 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 941968005817 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 941968005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968005819 putative substrate translocation pore; other site 941968005822 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 941968005823 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 941968005824 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 941968005825 active site 941968005826 HIGH motif; other site 941968005827 KMSK motif region; other site 941968005828 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 941968005829 tRNA binding surface [nucleotide binding]; other site 941968005830 anticodon binding site; other site 941968005836 transaminase; Validated; Region: PRK07324 941968005837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968005839 homodimer interface [polypeptide binding]; other site 941968005840 catalytic residue [active] 941968005842 FOG: CBS domain [General function prediction only]; Region: COG0517 941968005843 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 941968005846 1 probable transmembrane helix predicted for cbot01155 by TMHMM2.0 at aa 15-37 941968005849 1 probable transmembrane helix predicted for cbot01156 by TMHMM2.0 at aa 28-50 941968005850 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 941968005851 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 941968005852 G1 box; other site 941968005853 GTP/Mg2+ binding site [chemical binding]; other site 941968005854 Switch I region; other site 941968005855 G2 box; other site 941968005856 G3 box; other site 941968005857 Switch II region; other site 941968005858 G4 box; other site 941968005859 G5 box; other site 941968005860 Nucleoside recognition; Region: Gate; pfam07670 941968005861 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 941968005862 Nucleoside recognition; Region: Gate; pfam07670 941968005868 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 941968005871 PilZ domain; Region: PilZ; pfam07238 941968005873 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 941968005874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968005875 motif II; other site 941968005878 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 941968005879 active site 941968005880 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 941968005881 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 941968005882 aromatic chitin/cellulose binding site residues [chemical binding]; other site 941968005883 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 941968005884 aromatic chitin/cellulose binding site residues [chemical binding]; other site 941968005893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968005894 Coenzyme A binding pocket [chemical binding]; other site 941968005897 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 941968005898 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941968005899 Walker A/P-loop; other site 941968005900 ATP binding site [chemical binding]; other site 941968005901 Q-loop/lid; other site 941968005902 ABC transporter signature motif; other site 941968005903 Walker B; other site 941968005904 D-loop; other site 941968005905 H-loop/switch region; other site 941968005906 NIL domain; Region: NIL; pfam09383 941968005911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968005912 dimer interface [polypeptide binding]; other site 941968005913 conserved gate region; other site 941968005914 ABC-ATPase subunit interface; other site 941968005917 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941968005918 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941968005923 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941968005924 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941968005929 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941968005930 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 941968005931 metal binding site [ion binding]; metal-binding site 941968005932 putative dimer interface [polypeptide binding]; other site 941968005936 RNase_H superfamily; Region: RNase_H_2; pfam13482 941968005937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968005938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968005939 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941968005940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968005941 DNA-binding site [nucleotide binding]; DNA binding site 941968005942 FCD domain; Region: FCD; pfam07729 941968005948 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941968005949 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941968005950 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941968005951 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941968005958 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 941968005959 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941968005960 active site 941968005961 HIGH motif; other site 941968005962 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941968005963 active site 941968005964 KMSKS motif; other site 941968005968 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 941968005969 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 941968005970 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941968005974 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 941968005975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 941968005976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968005977 Beta-Casp domain; Region: Beta-Casp; smart01027 941968005978 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941968005983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968005984 Zn2+ binding site [ion binding]; other site 941968005985 Mg2+ binding site [ion binding]; other site 941968005988 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 941968005989 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 941968005990 NAD(P) binding site [chemical binding]; other site 941968005991 catalytic residues [active] 941968005996 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968005997 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968006001 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968006002 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968006006 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968006007 MarR family; Region: MarR_2; pfam12802 941968006009 1 probable transmembrane helix predicted for cbot01182 by TMHMM2.0 at aa 27-49 941968006011 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968006012 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 941968006015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968006018 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 941968006019 1 probable transmembrane helix predicted for cbot01185 by TMHMM2.0 at aa 20-42 941968006021 hypothetical protein; Provisional; Region: PRK11622 941968006022 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941968006025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006026 dimer interface [polypeptide binding]; other site 941968006027 conserved gate region; other site 941968006028 putative PBP binding loops; other site 941968006029 ABC-ATPase subunit interface; other site 941968006031 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941968006032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006033 dimer interface [polypeptide binding]; other site 941968006034 conserved gate region; other site 941968006035 putative PBP binding loops; other site 941968006036 ABC-ATPase subunit interface; other site 941968006040 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941968006041 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 941968006042 Walker A/P-loop; other site 941968006043 ATP binding site [chemical binding]; other site 941968006044 Q-loop/lid; other site 941968006045 ABC transporter signature motif; other site 941968006046 Walker B; other site 941968006047 D-loop; other site 941968006048 H-loop/switch region; other site 941968006052 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 941968006054 1 probable transmembrane helix predicted for cbot01190 by TMHMM2.0 at aa 23-45 941968006056 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968006057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968006058 Coenzyme A binding pocket [chemical binding]; other site 941968006060 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941968006061 catalytic residues [active] 941968006063 1 probable transmembrane helix predicted for cbot01192 by TMHMM2.0 at aa 21-43 941968006064 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 941968006066 maltose O-acetyltransferase; Provisional; Region: PRK10092 941968006067 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 941968006068 active site 941968006069 substrate binding site [chemical binding]; other site 941968006070 trimer interface [polypeptide binding]; other site 941968006071 CoA binding site [chemical binding]; other site 941968006075 1 probable transmembrane helix predicted for cbot01195 by TMHMM2.0 at aa 5-24 941968006078 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 941968006079 Biotin operon repressor [Transcription]; Region: BirA; COG1654 941968006080 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 941968006081 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 941968006085 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968006086 metal-binding site [ion binding] 941968006088 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 941968006089 FOG: CBS domain [General function prediction only]; Region: COG0517 941968006093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968006094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968006095 dimer interface [polypeptide binding]; other site 941968006096 phosphorylation site [posttranslational modification] 941968006097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968006098 ATP binding site [chemical binding]; other site 941968006099 Mg2+ binding site [ion binding]; other site 941968006100 G-X-G motif; other site 941968006107 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941968006108 nucleophile elbow; other site 941968006109 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 941968006110 MgtE intracellular N domain; Region: MgtE_N; smart00924 941968006111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 941968006112 Divalent cation transporter; Region: MgtE; pfam01769 941968006120 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 941968006121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968006122 catalytic residue [active] 941968006124 1 probable transmembrane helix predicted for cbot01203 by TMHMM2.0 at aa 29-51 941968006125 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 941968006126 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 941968006127 putative ligand binding site [chemical binding]; other site 941968006128 NAD binding site [chemical binding]; other site 941968006129 dimerization interface [polypeptide binding]; other site 941968006130 catalytic site [active] 941968006133 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 941968006134 Uncharacterized conserved protein [Function unknown]; Region: COG4198 941968006138 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 941968006139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968006140 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968006145 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968006146 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 941968006147 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968006148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 941968006149 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968006150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 941968006158 BCCT family transporter; Region: BCCT; pfam02028 941968006162 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941968006163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968006164 DNA-binding site [nucleotide binding]; DNA binding site 941968006165 TrkA-C domain; Region: TrkA_C; pfam02080 941968006169 Flavin Reductases; Region: FlaRed; cl00801 941968006171 potential frameshift: common BLAST hit: gi|148379121|ref|YP_001253662.1| pyrazinamidase/nicotinamidase 941968006172 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 941968006174 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 941968006175 catalytic triad [active] 941968006176 conserved cis-peptide bond; other site 941968006179 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941968006180 active site residue [active] 941968006183 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 941968006184 TPR repeat; Region: TPR_11; pfam13414 941968006185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968006186 binding surface 941968006187 TPR motif; other site 941968006188 TPR repeat; Region: TPR_11; pfam13414 941968006189 TPR repeat; Region: TPR_11; pfam13414 941968006190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968006191 binding surface 941968006192 TPR motif; other site 941968006193 TPR repeat; Region: TPR_11; pfam13414 941968006205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968006206 active site 941968006208 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 941968006209 Rhodanese Homology Domain; Region: RHOD; smart00450 941968006210 active site residue [active] 941968006211 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941968006212 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 941968006213 active site residue [active] 941968006214 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941968006215 active site residue [active] 941968006225 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941968006226 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941968006229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 941968006230 putative metal binding site [ion binding]; other site 941968006232 1 probable transmembrane helix predicted for cbot01223 by TMHMM2.0 at aa 7-29 941968006234 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 941968006235 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 941968006236 active site 941968006237 metal-binding site [ion binding] 941968006238 nucleotide-binding site [chemical binding]; other site 941968006241 1 probable transmembrane helix predicted for cbot01225 by TMHMM2.0 at aa 39-61 941968006242 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 941968006243 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941968006249 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 941968006250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006251 dimer interface [polypeptide binding]; other site 941968006252 conserved gate region; other site 941968006253 putative PBP binding loops; other site 941968006254 ABC-ATPase subunit interface; other site 941968006255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006256 dimer interface [polypeptide binding]; other site 941968006257 conserved gate region; other site 941968006258 putative PBP binding loops; other site 941968006259 ABC-ATPase subunit interface; other site 941968006267 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 941968006268 Double zinc ribbon; Region: DZR; pfam12773 941968006269 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 941968006270 Double zinc ribbon; Region: DZR; pfam12773 941968006271 YARHG domain; Region: YARHG; pfam13308 941968006272 1 probable transmembrane helix predicted for cbot01230 by TMHMM2.0 at aa 117-136 941968006273 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 941968006274 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 941968006275 RNA binding site [nucleotide binding]; other site 941968006276 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 941968006277 RNA binding site [nucleotide binding]; other site 941968006278 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 941968006279 RNA binding site [nucleotide binding]; other site 941968006280 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 941968006281 RNA binding site [nucleotide binding]; other site 941968006293 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941968006294 active site 941968006296 1 probable transmembrane helix predicted for cbot01233 by TMHMM2.0 at aa 29-51 941968006297 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 941968006298 hexamer interface [polypeptide binding]; other site 941968006299 RNA binding site [nucleotide binding]; other site 941968006300 Histidine-zinc binding site [chemical binding]; other site 941968006302 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 941968006303 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 941968006304 zinc binding site [ion binding]; other site 941968006305 putative ligand binding site [chemical binding]; other site 941968006309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941968006310 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 941968006311 TM-ABC transporter signature motif; other site 941968006313 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 941968006314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968006315 Walker A/P-loop; other site 941968006316 ATP binding site [chemical binding]; other site 941968006317 Q-loop/lid; other site 941968006318 ABC transporter signature motif; other site 941968006319 Walker B; other site 941968006320 D-loop; other site 941968006321 H-loop/switch region; other site 941968006324 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 941968006325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968006326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968006327 homodimer interface [polypeptide binding]; other site 941968006328 catalytic residue [active] 941968006330 1 probable transmembrane helix predicted for cbot01239 by TMHMM2.0 at aa 58-80 941968006332 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941968006333 EamA-like transporter family; Region: EamA; pfam00892 941968006334 EamA-like transporter family; Region: EamA; pfam00892 941968006338 putative kinase; Provisional; Region: PRK09954 941968006339 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 941968006340 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 941968006341 substrate binding site [chemical binding]; other site 941968006342 ATP binding site [chemical binding]; other site 941968006344 1 probable transmembrane helix predicted for cbot01241 by TMHMM2.0 at aa 40-62 941968006346 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 941968006348 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 941968006349 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941968006350 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 941968006353 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 941968006356 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 941968006357 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 941968006358 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 941968006359 homodimer interface [polypeptide binding]; other site 941968006360 NADP binding site [chemical binding]; other site 941968006361 substrate binding site [chemical binding]; other site 941968006365 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941968006366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968006367 active site 941968006368 motif I; other site 941968006369 motif II; other site 941968006370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941968006372 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941968006374 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 941968006375 ZIP Zinc transporter; Region: Zip; pfam02535 941968006378 Predicted transcriptional regulator [Transcription]; Region: COG1959 941968006379 Transcriptional regulator; Region: Rrf2; cl17282 941968006381 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941968006382 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941968006383 dimer interface [polypeptide binding]; other site 941968006384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968006385 catalytic residue [active] 941968006390 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941968006391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006392 dimer interface [polypeptide binding]; other site 941968006393 conserved gate region; other site 941968006394 putative PBP binding loops; other site 941968006395 ABC-ATPase subunit interface; other site 941968006397 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941968006398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941968006399 substrate binding pocket [chemical binding]; other site 941968006400 membrane-bound complex binding site; other site 941968006401 hinge residues; other site 941968006407 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 941968006408 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 941968006409 Ligand Binding Site [chemical binding]; other site 941968006411 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 941968006412 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 941968006413 Ligand Binding Site [chemical binding]; other site 941968006415 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941968006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968006417 active site 941968006418 phosphorylation site [posttranslational modification] 941968006419 intermolecular recognition site; other site 941968006420 LytTr DNA-binding domain; Region: LytTR; pfam04397 941968006425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968006426 ATP binding site [chemical binding]; other site 941968006427 Mg2+ binding site [ion binding]; other site 941968006428 G-X-G motif; other site 941968006430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968006431 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 941968006432 Walker A/P-loop; other site 941968006433 ATP binding site [chemical binding]; other site 941968006434 Q-loop/lid; other site 941968006435 ABC transporter signature motif; other site 941968006436 Walker B; other site 941968006437 D-loop; other site 941968006438 H-loop/switch region; other site 941968006444 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 941968006445 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 941968006446 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941968006447 active site 941968006448 catalytic site [active] 941968006452 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 941968006454 1 probable transmembrane helix predicted for cbot01266 by TMHMM2.0 at aa 20-42 941968006455 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 941968006456 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 941968006457 dimer interface [polypeptide binding]; other site 941968006458 PYR/PP interface [polypeptide binding]; other site 941968006459 TPP binding site [chemical binding]; other site 941968006460 substrate binding site [chemical binding]; other site 941968006461 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 941968006462 Domain of unknown function; Region: EKR; pfam10371 941968006463 4Fe-4S binding domain; Region: Fer4_6; pfam12837 941968006464 4Fe-4S binding domain; Region: Fer4; pfam00037 941968006465 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 941968006466 TPP-binding site [chemical binding]; other site 941968006467 dimer interface [polypeptide binding]; other site 941968006468 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 941968006469 TPP-binding site [chemical binding]; other site 941968006475 1 probable transmembrane helix predicted for cbot01268 by TMHMM2.0 at aa 24-46 941968006478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968006479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968006481 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941968006482 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941968006488 Uncharacterized conserved protein [Function unknown]; Region: COG0397 941968006489 hypothetical protein; Validated; Region: PRK00029 941968006492 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 941968006493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968006498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 941968006499 Helix-turn-helix domain; Region: HTH_18; pfam12833 941968006500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968006504 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 941968006505 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 941968006507 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 941968006509 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 941968006510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968006511 nucleotide binding site [chemical binding]; other site 941968006514 1 probable transmembrane helix predicted for cbot01276 by TMHMM2.0 at aa 20-42 941968006515 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 941968006516 beta-galactosidase; Region: BGL; TIGR03356 941968006518 1 probable transmembrane helix predicted for cbot01277 by TMHMM2.0 at aa 33-55 941968006519 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 941968006520 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 941968006521 starch-binding site 2 [chemical binding]; other site 941968006522 starch-binding site 1 [chemical binding]; other site 941968006526 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 941968006527 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 941968006528 active site 941968006529 HIGH motif; other site 941968006530 dimer interface [polypeptide binding]; other site 941968006531 KMSKS motif; other site 941968006532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968006533 RNA binding surface [nucleotide binding]; other site 941968006538 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968006539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968006540 DNA-binding site [nucleotide binding]; DNA binding site 941968006543 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968006544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968006545 Walker A/P-loop; other site 941968006546 ATP binding site [chemical binding]; other site 941968006547 Q-loop/lid; other site 941968006548 ABC transporter signature motif; other site 941968006549 Walker B; other site 941968006550 D-loop; other site 941968006551 H-loop/switch region; other site 941968006554 1 probable transmembrane helix predicted for cbot01281 by TMHMM2.0 at aa 34-53 941968006561 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968006562 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 941968006563 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968006564 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968006565 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 941968006566 active site 941968006576 PAS domain S-box; Region: sensory_box; TIGR00229 941968006577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968006578 putative active site [active] 941968006579 heme pocket [chemical binding]; other site 941968006580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968006581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968006582 metal binding site [ion binding]; metal-binding site 941968006583 active site 941968006584 I-site; other site 941968006591 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 941968006592 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 941968006593 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941968006596 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 941968006597 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 941968006601 Uncharacterized conserved protein [Function unknown]; Region: COG5663 941968006603 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 941968006604 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 941968006605 active site 941968006606 dimer interface [polypeptide binding]; other site 941968006608 1 probable transmembrane helix predicted for cbot01293 by TMHMM2.0 at aa 27-44 941968006609 Yip1 domain; Region: Yip1; pfam04893 941968006611 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 941968006612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968006613 FtsX-like permease family; Region: FtsX; pfam02687 941968006615 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 941968006616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968006617 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968006618 Walker A/P-loop; other site 941968006619 ATP binding site [chemical binding]; other site 941968006620 Q-loop/lid; other site 941968006621 ABC transporter signature motif; other site 941968006622 Walker B; other site 941968006623 D-loop; other site 941968006624 H-loop/switch region; other site 941968006627 1 probable transmembrane helix predicted for cbot01297 by TMHMM2.0 at aa 67-89 941968006629 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 941968006630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006631 dimer interface [polypeptide binding]; other site 941968006632 conserved gate region; other site 941968006633 putative PBP binding loops; other site 941968006634 ABC-ATPase subunit interface; other site 941968006637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941968006638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968006639 dimer interface [polypeptide binding]; other site 941968006640 conserved gate region; other site 941968006641 putative PBP binding loops; other site 941968006642 ABC-ATPase subunit interface; other site 941968006644 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941968006645 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 941968006648 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 941968006649 CotJB protein; Region: CotJB; pfam12652 941968006650 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 941968006651 dimanganese center [ion binding]; other site 941968006654 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 941968006656 1 probable transmembrane helix predicted for cbot01304 by TMHMM2.0 at aa 21-43 941968006657 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 941968006663 Tubby C 2; Region: Tub_2; cl02043 941968006666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 941968006667 trimer interface [polypeptide binding]; other site 941968006668 active site 941968006669 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 941968006671 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 941968006673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968006674 non-specific DNA binding site [nucleotide binding]; other site 941968006675 salt bridge; other site 941968006676 sequence-specific DNA binding site [nucleotide binding]; other site 941968006677 Cupin domain; Region: Cupin_2; pfam07883 941968006681 1 probable transmembrane helix predicted for cbot01313 by TMHMM2.0 at aa 5-27 941968006682 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 941968006683 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 941968006686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968006687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968006689 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 941968006690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968006691 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 941968006692 Walker A/P-loop; other site 941968006693 ATP binding site [chemical binding]; other site 941968006694 Q-loop/lid; other site 941968006695 ABC transporter signature motif; other site 941968006696 Walker B; other site 941968006697 D-loop; other site 941968006698 H-loop/switch region; other site 941968006704 1 probable transmembrane helix predicted for cbot01319 by TMHMM2.0 at aa 29-51 941968006705 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968006706 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 941968006709 1 probable transmembrane helix predicted for cbot01322 by TMHMM2.0 at aa 30-52 941968006710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968006711 non-specific DNA binding site [nucleotide binding]; other site 941968006712 salt bridge; other site 941968006713 sequence-specific DNA binding site [nucleotide binding]; other site 941968006716 Helix-turn-helix domain; Region: HTH_17; pfam12728 941968006717 putative transposase OrfB; Reviewed; Region: PHA02517 941968006718 HTH-like domain; Region: HTH_21; pfam13276 941968006719 Integrase core domain; Region: rve; pfam00665 941968006720 Integrase core domain; Region: rve_2; pfam13333 941968006723 Winged helix-turn helix; Region: HTH_29; pfam13551 941968006724 Helix-turn-helix domain; Region: HTH_28; pfam13518 941968006728 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 941968006729 catalytic residues [active] 941968006731 1 probable transmembrane helix predicted for cbot01329 by TMHMM2.0 at aa 34-56 941968006732 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 941968006733 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 941968006734 tetrameric interface [polypeptide binding]; other site 941968006735 activator binding site; other site 941968006736 NADP binding site [chemical binding]; other site 941968006737 substrate binding site [chemical binding]; other site 941968006738 catalytic residues [active] 941968006741 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 941968006742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968006745 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 941968006748 potential frameshift: common BLAST hit: gi|153936840|ref|YP_001387163.1| glycine reductase, selenoprotein B 941968006749 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355 941968006750 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 941968006753 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 941968006754 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 941968006755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968006756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968006761 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941968006762 catalytic residues [active] 941968006764 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 941968006765 Glycine reductase complex selenoprotein A; Region: GRDA; cl04705 941968006768 Thermoplasma acidophilum protein TA0956; Region: TA0956; pfam11513 941968006769 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 941968006770 dimer interface [polypeptide binding]; other site 941968006771 active site 941968006776 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 941968006779 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 941968006780 active site 941968006781 DNA binding site [nucleotide binding] 941968006785 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 941968006786 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 941968006788 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 941968006789 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 941968006791 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 941968006792 Phosphotransferase enzyme family; Region: APH; pfam01636 941968006794 1 probable transmembrane helix predicted for cbot01345 by TMHMM2.0 at aa 13-35 941968006796 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 941968006797 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 941968006801 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 941968006802 intersubunit interface [polypeptide binding]; other site 941968006803 active site 941968006804 Zn2+ binding site [ion binding]; other site 941968006808 1 probable transmembrane helix predicted for cbot01347 by TMHMM2.0 at aa 10-32 941968006809 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941968006810 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941968006811 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941968006816 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 941968006819 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941968006820 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 941968006822 Predicted membrane protein [Function unknown]; Region: COG2323 941968006825 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 941968006826 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 941968006828 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 941968006830 A short protein domain of unknown function; Region: IDEAL; smart00914 941968006831 1 probable transmembrane helix predicted for cbot01357 by TMHMM2.0 at aa 26-48 941968006836 PQ loop repeat; Region: PQ-loop; cl17546 941968006838 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 941968006839 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941968006840 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941968006846 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 941968006847 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 941968006850 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941968006851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941968006852 catalytic loop [active] 941968006853 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 941968006854 iron binding site [ion binding]; other site 941968006855 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941968006857 1 probable transmembrane helix predicted for cbot01362 by TMHMM2.0 at aa 42-61 941968006859 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941968006860 nucleoside/Zn binding site; other site 941968006861 dimer interface [polypeptide binding]; other site 941968006862 catalytic motif [active] 941968006864 1 probable transmembrane helix predicted for cbot01363 by TMHMM2.0 at aa 7-29 941968006865 DNA topoisomerase III; Provisional; Region: PRK07726 941968006866 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 941968006867 active site 941968006868 putative interdomain interaction site [polypeptide binding]; other site 941968006869 putative metal-binding site [ion binding]; other site 941968006870 putative nucleotide binding site [chemical binding]; other site 941968006871 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941968006872 domain I; other site 941968006873 DNA binding groove [nucleotide binding] 941968006874 phosphate binding site [ion binding]; other site 941968006875 domain II; other site 941968006876 domain III; other site 941968006877 nucleotide binding site [chemical binding]; other site 941968006878 catalytic site [active] 941968006879 domain IV; other site 941968006887 Predicted membrane protein [Function unknown]; Region: COG1971 941968006888 Domain of unknown function DUF; Region: DUF204; pfam02659 941968006891 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 941968006893 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 941968006894 active site 941968006895 intersubunit interactions; other site 941968006896 catalytic residue [active] 941968006899 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 941968006900 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968006901 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941968006907 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968006908 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968006913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968006914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968006915 metal binding site [ion binding]; metal-binding site 941968006916 active site 941968006917 I-site; other site 941968006921 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 941968006922 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 941968006923 NodB motif; other site 941968006924 putative active site [active] 941968006925 putative catalytic site [active] 941968006926 putative Zn binding site [ion binding]; other site 941968006929 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941968006930 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 941968006931 DXD motif; other site 941968006935 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 941968006938 Probable zinc-binding domain; Region: zf-trcl; pfam13451 941968006939 1 probable transmembrane helix predicted for cbot01376 by TMHMM2.0 at aa 7-29 941968006940 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 941968006942 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 941968006943 putative homodimer interface [polypeptide binding]; other site 941968006944 putative homotetramer interface [polypeptide binding]; other site 941968006945 putative allosteric switch controlling residues; other site 941968006946 putative metal binding site [ion binding]; other site 941968006947 putative homodimer-homodimer interface [polypeptide binding]; other site 941968006949 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941968006950 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968006951 metal-binding site [ion binding] 941968006952 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941968006953 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968006954 metal-binding site [ion binding] 941968006955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968006956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968006957 motif II; other site 941968006964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941968006965 metal-binding site [ion binding] 941968006967 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968006968 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968006969 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968006970 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968006971 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968006975 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968006976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968006977 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941968006978 Walker A/P-loop; other site 941968006979 ATP binding site [chemical binding]; other site 941968006980 Q-loop/lid; other site 941968006981 ABC transporter signature motif; other site 941968006982 Walker B; other site 941968006983 D-loop; other site 941968006984 H-loop/switch region; other site 941968006991 EDD domain protein, DegV family; Region: DegV; TIGR00762 941968006992 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941968006994 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 941968006996 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 941968006997 nucleotide binding site/active site [active] 941968006998 HIT family signature motif; other site 941968006999 catalytic residue [active] 941968007001 1 probable transmembrane helix predicted for cbot01387 by TMHMM2.0 at aa 25-47 941968007002 Membrane protein of unknown function; Region: DUF360; pfam04020 941968007009 YibE/F-like protein; Region: YibE_F; pfam07907 941968007012 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 941968007013 TrkA-N domain; Region: TrkA_N; pfam02254 941968007014 TrkA-C domain; Region: TrkA_C; pfam02080 941968007015 TrkA-N domain; Region: TrkA_N; pfam02254 941968007016 TrkA-C domain; Region: TrkA_C; pfam02080 941968007024 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 941968007025 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 941968007027 potential frameshift: common BLAST hit: gi|153939167|ref|YP_001390679.1| helicase, UvrD/REP/exonuclease family protein 941968007028 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 941968007029 Part of AAA domain; Region: AAA_19; pfam13245 941968007030 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941968007033 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941968007034 active site 941968007035 substrate binding site [chemical binding]; other site 941968007036 catalytic site [active] 941968007037 Family description; Region: UvrD_C_2; pfam13538 941968007041 Predicted membrane protein [General function prediction only]; Region: COG4194 941968007043 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 941968007045 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968007046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968007047 DNA-binding site [nucleotide binding]; DNA binding site 941968007050 1 probable transmembrane helix predicted for cbot01398 by TMHMM2.0 at aa 21-43 941968007052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968007053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968007054 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941968007061 Rubrerythrin [Energy production and conversion]; Region: COG1592 941968007062 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 941968007063 binuclear metal center [ion binding]; other site 941968007064 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 941968007065 iron binding site [ion binding]; other site 941968007068 1 probable transmembrane helix predicted for cbot01400 by TMHMM2.0 at aa 20-42 941968007069 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968007070 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968007071 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968007076 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968007077 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 941968007078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968007079 active site turn [active] 941968007080 phosphorylation site [posttranslational modification] 941968007081 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 941968007082 HPr interaction site; other site 941968007083 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968007084 active site 941968007085 phosphorylation site [posttranslational modification] 941968007091 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 941968007092 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 941968007093 catalytic residue [active] 941968007094 putative FPP diphosphate binding site; other site 941968007095 putative FPP binding hydrophobic cleft; other site 941968007096 dimer interface [polypeptide binding]; other site 941968007097 putative IPP diphosphate binding site; other site 941968007099 1 probable transmembrane helix predicted for cbot01403 by TMHMM2.0 at aa 29-48 941968007103 Rrf2 family protein; Region: rrf2_super; TIGR00738 941968007104 Transcriptional regulator; Region: Rrf2; pfam02082 941968007107 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 941968007108 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968007109 ACS interaction site; other site 941968007110 CODH interaction site; other site 941968007111 metal cluster binding site [ion binding]; other site 941968007114 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 941968007115 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968007116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941968007120 potential frameshift: common BLAST hit: gi|148379313|ref|YP_001253854.1| transporter 941968007122 1 probable transmembrane helix predicted for cbot01409 by TMHMM2.0 at aa 15-37 941968007123 EamA-like transporter family; Region: EamA; pfam00892 941968007125 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968007126 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968007127 ligand binding site [chemical binding]; other site 941968007128 flexible hinge region; other site 941968007129 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941968007130 putative switch regulator; other site 941968007131 non-specific DNA interactions [nucleotide binding]; other site 941968007132 DNA binding site [nucleotide binding] 941968007133 sequence specific DNA binding site [nucleotide binding]; other site 941968007134 putative cAMP binding site [chemical binding]; other site 941968007139 1 probable transmembrane helix predicted for cbot01411 by TMHMM2.0 at aa 15-37 941968007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968007141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968007142 putative substrate translocation pore; other site 941968007144 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941968007145 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 941968007146 putative binding site residues; other site 941968007148 1 probable transmembrane helix predicted for cbot01413 by TMHMM2.0 at aa 15-34 941968007150 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 941968007151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968007152 ABC-ATPase subunit interface; other site 941968007153 dimer interface [polypeptide binding]; other site 941968007154 putative PBP binding regions; other site 941968007157 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968007158 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968007159 Walker A/P-loop; other site 941968007160 ATP binding site [chemical binding]; other site 941968007161 Q-loop/lid; other site 941968007162 ABC transporter signature motif; other site 941968007163 Walker B; other site 941968007164 D-loop; other site 941968007165 H-loop/switch region; other site 941968007168 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968007169 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941968007172 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968007173 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968007174 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968007175 putative active site [active] 941968007179 Uncharacterized conserved protein [Function unknown]; Region: COG3589 941968007182 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 941968007184 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 941968007186 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968007187 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 941968007190 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968007195 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 941968007197 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941968007198 HAMP domain; Region: HAMP; pfam00672 941968007199 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968007200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968007201 dimer interface [polypeptide binding]; other site 941968007202 putative CheW interface [polypeptide binding]; other site 941968007207 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941968007208 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 941968007211 1 probable transmembrane helix predicted for cbot01427 by TMHMM2.0 at aa 12-29 941968007213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941968007214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007215 dimer interface [polypeptide binding]; other site 941968007216 conserved gate region; other site 941968007217 putative PBP binding loops; other site 941968007218 ABC-ATPase subunit interface; other site 941968007221 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 941968007222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007223 dimer interface [polypeptide binding]; other site 941968007224 conserved gate region; other site 941968007225 putative PBP binding loops; other site 941968007226 ABC-ATPase subunit interface; other site 941968007229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968007230 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 941968007231 Walker A/P-loop; other site 941968007232 ATP binding site [chemical binding]; other site 941968007233 Q-loop/lid; other site 941968007234 ABC transporter signature motif; other site 941968007235 Walker B; other site 941968007236 D-loop; other site 941968007237 H-loop/switch region; other site 941968007238 1 probable transmembrane helix predicted for cbot01430 by TMHMM2.0 at aa 13-35 941968007241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941968007242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968007243 Walker A/P-loop; other site 941968007244 ATP binding site [chemical binding]; other site 941968007245 Q-loop/lid; other site 941968007246 ABC transporter signature motif; other site 941968007247 Walker B; other site 941968007248 D-loop; other site 941968007249 H-loop/switch region; other site 941968007253 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 941968007254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968007255 ABC-ATPase subunit interface; other site 941968007256 dimer interface [polypeptide binding]; other site 941968007257 putative PBP binding regions; other site 941968007260 potential frameshift: common BLAST hit: gi|384461782|ref|YP_005674377.1| manganese/zinc/iron chelate uptake ABC transporter, Mzt family 941968007261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968007262 ABC transporter signature motif; other site 941968007263 Walker B; other site 941968007264 D-loop; other site 941968007265 H-loop/switch region; other site 941968007267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968007268 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968007269 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 941968007270 intersubunit interface [polypeptide binding]; other site 941968007274 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941968007275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968007276 nucleotide binding region [chemical binding]; other site 941968007277 ATP-binding site [chemical binding]; other site 941968007278 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 941968007282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968007283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968007284 metal binding site [ion binding]; metal-binding site 941968007285 active site 941968007286 I-site; other site 941968007290 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941968007291 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941968007296 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941968007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007298 dimer interface [polypeptide binding]; other site 941968007299 conserved gate region; other site 941968007300 putative PBP binding loops; other site 941968007301 ABC-ATPase subunit interface; other site 941968007303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968007304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968007305 Walker A/P-loop; other site 941968007306 ATP binding site [chemical binding]; other site 941968007307 Q-loop/lid; other site 941968007308 ABC transporter signature motif; other site 941968007309 Walker B; other site 941968007310 D-loop; other site 941968007311 H-loop/switch region; other site 941968007314 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941968007315 metal binding site 2 [ion binding]; metal-binding site 941968007316 putative DNA binding helix; other site 941968007317 metal binding site 1 [ion binding]; metal-binding site 941968007318 dimer interface [polypeptide binding]; other site 941968007319 structural Zn2+ binding site [ion binding]; other site 941968007321 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 941968007322 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968007324 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941968007325 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 941968007326 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968007327 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 941968007328 putative active site [active] 941968007329 Zn binding site [ion binding]; other site 941968007330 1 probable transmembrane helix predicted for cbot01446 by TMHMM2.0 at aa 4-23 941968007336 ribonuclease Z; Region: RNase_Z; TIGR02651 941968007338 L-type amino acid transporter; Region: 2A0308; TIGR00911 941968007341 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 941968007342 pentamer interface [polypeptide binding]; other site 941968007343 dodecaamer interface [polypeptide binding]; other site 941968007345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 941968007346 Histidine kinase; Region: HisKA_3; pfam07730 941968007347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968007348 ATP binding site [chemical binding]; other site 941968007349 Mg2+ binding site [ion binding]; other site 941968007350 G-X-G motif; other site 941968007353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941968007354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968007355 active site 941968007356 phosphorylation site [posttranslational modification] 941968007357 intermolecular recognition site; other site 941968007358 dimerization interface [polypeptide binding]; other site 941968007359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941968007360 DNA binding residues [nucleotide binding] 941968007361 dimerization interface [polypeptide binding]; other site 941968007366 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968007367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968007368 Walker A/P-loop; other site 941968007369 ATP binding site [chemical binding]; other site 941968007370 Q-loop/lid; other site 941968007371 ABC transporter signature motif; other site 941968007372 Walker B; other site 941968007373 D-loop; other site 941968007374 H-loop/switch region; other site 941968007377 1 probable transmembrane helix predicted for cbot01453 by TMHMM2.0 at aa 7-29 941968007380 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941968007383 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941968007384 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 941968007386 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 941968007387 FMN binding site [chemical binding]; other site 941968007388 dimer interface [polypeptide binding]; other site 941968007390 1 probable transmembrane helix predicted for cbot01458 by TMHMM2.0 at aa 25-47 941968007392 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 941968007393 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 941968007394 metal binding site [ion binding]; metal-binding site 941968007395 dimer interface [polypeptide binding]; other site 941968007399 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968007406 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 941968007407 dimer interface [polypeptide binding]; other site 941968007408 pyridoxal binding site [chemical binding]; other site 941968007409 ATP binding site [chemical binding]; other site 941968007411 1 probable transmembrane helix predicted for cbot01462 by TMHMM2.0 at aa 10-32 941968007413 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 941968007416 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968007417 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968007418 Walker A/P-loop; other site 941968007419 ATP binding site [chemical binding]; other site 941968007420 Q-loop/lid; other site 941968007421 ABC transporter signature motif; other site 941968007422 Walker B; other site 941968007423 D-loop; other site 941968007424 H-loop/switch region; other site 941968007428 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968007429 FtsX-like permease family; Region: FtsX; pfam02687 941968007436 1 probable transmembrane helix predicted for cbot01466 by TMHMM2.0 at aa 13-32 941968007437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968007438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968007439 active site 941968007440 phosphorylation site [posttranslational modification] 941968007441 intermolecular recognition site; other site 941968007442 dimerization interface [polypeptide binding]; other site 941968007443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968007444 DNA binding site [nucleotide binding] 941968007448 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968007449 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 941968007450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968007451 ATP binding site [chemical binding]; other site 941968007452 Mg2+ binding site [ion binding]; other site 941968007453 G-X-G motif; other site 941968007458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968007459 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968007460 Walker A/P-loop; other site 941968007461 ATP binding site [chemical binding]; other site 941968007462 Q-loop/lid; other site 941968007463 ABC transporter signature motif; other site 941968007464 Walker B; other site 941968007465 D-loop; other site 941968007466 H-loop/switch region; other site 941968007472 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 941968007473 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 941968007475 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 941968007478 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 941968007479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968007480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968007481 homodimer interface [polypeptide binding]; other site 941968007482 catalytic residue [active] 941968007485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941968007486 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941968007487 substrate binding pocket [chemical binding]; other site 941968007488 membrane-bound complex binding site; other site 941968007489 hinge residues; other site 941968007495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007496 dimer interface [polypeptide binding]; other site 941968007497 conserved gate region; other site 941968007498 putative PBP binding loops; other site 941968007499 ABC-ATPase subunit interface; other site 941968007502 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941968007503 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941968007504 Walker A/P-loop; other site 941968007505 ATP binding site [chemical binding]; other site 941968007506 Q-loop/lid; other site 941968007507 ABC transporter signature motif; other site 941968007508 Walker B; other site 941968007509 D-loop; other site 941968007510 H-loop/switch region; other site 941968007516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968007517 non-specific DNA binding site [nucleotide binding]; other site 941968007518 salt bridge; other site 941968007519 sequence-specific DNA binding site [nucleotide binding]; other site 941968007523 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 941968007524 putative active site [active] 941968007525 putative CoA binding site [chemical binding]; other site 941968007526 nudix motif; other site 941968007527 metal binding site [ion binding]; metal-binding site 941968007529 1 probable transmembrane helix predicted for cbot01481 by TMHMM2.0 at aa 5-27 941968007531 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 941968007532 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 941968007533 dimer interface [polypeptide binding]; other site 941968007534 active site 941968007535 metal binding site [ion binding]; metal-binding site 941968007539 Predicted membrane protein [Function unknown]; Region: COG1288 941968007540 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 941968007544 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 941968007545 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 941968007546 active site 941968007550 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941968007551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941968007552 substrate binding pocket [chemical binding]; other site 941968007553 membrane-bound complex binding site; other site 941968007554 hinge residues; other site 941968007558 1 probable transmembrane helix predicted for cbot01486 by TMHMM2.0 at aa 7-24 941968007561 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941968007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007563 dimer interface [polypeptide binding]; other site 941968007564 conserved gate region; other site 941968007565 putative PBP binding loops; other site 941968007566 ABC-ATPase subunit interface; other site 941968007570 Protein of unknown function (DUF523); Region: DUF523; cl00733 941968007572 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 941968007573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968007574 ATP binding site [chemical binding]; other site 941968007575 Family description; Region: UvrD_C_2; pfam13538 941968007579 Phage tail protein; Region: Sipho_tail; cl17486 941968007582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968007583 Coenzyme A binding pocket [chemical binding]; other site 941968007585 1 probable transmembrane helix predicted for cbot01495 by TMHMM2.0 at aa 5-27 941968007586 1 probable transmembrane helix predicted for cbot01496 by TMHMM2.0 at aa 12-34 941968007587 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 941968007589 1 probable transmembrane helix predicted for cbot01498 by TMHMM2.0 at aa 5-27 941968007591 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968007592 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968007593 active site 941968007594 metal binding site [ion binding]; metal-binding site 941968007595 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941968007599 Coat F domain; Region: Coat_F; pfam07875 941968007601 1 probable transmembrane helix predicted for cbot01502 by TMHMM2.0 at aa 32-54 941968007605 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 941968007606 Family description; Region: UvrD_C_2; pfam13538 941968007607 cell division protein FtsA; Region: ftsA; TIGR01174 941968007608 Cell division protein FtsA; Region: FtsA; smart00842 941968007609 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 941968007610 Cell division protein FtsA; Region: FtsA; pfam14450 941968007617 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941968007618 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 941968007619 metal binding site [ion binding]; metal-binding site 941968007620 dimer interface [polypeptide binding]; other site 941968007629 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941968007630 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968007631 RNA binding surface [nucleotide binding]; other site 941968007632 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941968007633 active site 941968007636 1 probable transmembrane helix predicted for cbot01511 by TMHMM2.0 at aa 33-55 941968007638 stage V sporulation protein B; Region: spore_V_B; TIGR02900 941968007639 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941968007642 stage V sporulation protein B; Region: spore_V_B; TIGR02900 941968007643 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968007646 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 941968007647 diiron binding motif [ion binding]; other site 941968007649 1 probable transmembrane helix predicted for cbot01515 by TMHMM2.0 at aa 9-31 941968007650 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 941968007651 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 941968007652 putative active site [active] 941968007653 metal binding site [ion binding]; metal-binding site 941968007657 AAA domain; Region: AAA_32; pfam13654 941968007658 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 941968007659 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941968007663 potential frameshift: common BLAST hit: gi|226948705|ref|YP_002803796.1| thermolysin metallopeptidase 941968007664 Thermolysin metallopeptidase, alpha-helical domain; Region: Peptidase_M4_C; pfam02868 941968007666 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941968007668 1 probable transmembrane helix predicted for cbot01519 by TMHMM2.0 at aa 20-42 941968007670 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941968007671 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941968007672 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941968007673 active site 941968007674 Zn binding site [ion binding]; other site 941968007681 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941968007682 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941968007683 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 941968007684 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941968007685 active site 941968007686 Zn binding site [ion binding]; other site 941968007694 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941968007695 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 941968007696 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941968007697 active site 941968007698 Zn binding site [ion binding]; other site 941968007707 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941968007708 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 941968007709 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941968007710 active site 941968007711 Zn binding site [ion binding]; other site 941968007717 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 941968007718 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 941968007719 active site 941968007720 Zn binding site [ion binding]; other site 941968007726 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 941968007727 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 941968007728 dimerization interface [polypeptide binding]; other site 941968007729 active site 941968007733 1 probable transmembrane helix predicted for cbot01525 by TMHMM2.0 at aa 15-32 941968007735 L-aspartate oxidase; Provisional; Region: PRK06175 941968007736 FAD binding domain; Region: FAD_binding_2; pfam00890 941968007739 Quinolinate synthetase A protein; Region: NadA; pfam02445 941968007742 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 941968007743 Haemolysin-III related; Region: HlyIII; cl03831 941968007744 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 941968007746 GTP-binding protein YchF; Reviewed; Region: PRK09601 941968007747 YchF GTPase; Region: YchF; cd01900 941968007748 G1 box; other site 941968007749 GTP/Mg2+ binding site [chemical binding]; other site 941968007750 Switch I region; other site 941968007751 G2 box; other site 941968007752 Switch II region; other site 941968007753 G3 box; other site 941968007754 G4 box; other site 941968007755 G5 box; other site 941968007756 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 941968007761 cell division protein MraZ; Reviewed; Region: PRK00326 941968007762 MraZ protein; Region: MraZ; pfam02381 941968007763 MraZ protein; Region: MraZ; pfam02381 941968007766 MraW methylase family; Region: Methyltransf_5; pfam01795 941968007767 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 941968007772 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 941968007773 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941968007774 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941968007775 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 941968007776 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 941968007787 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 941968007788 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941968007789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968007790 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941968007794 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 941968007795 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941968007796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968007797 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941968007800 1 probable transmembrane helix predicted for cbot01537 by TMHMM2.0 at aa 41-63 941968007803 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 941968007804 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 941968007805 Mg++ binding site [ion binding]; other site 941968007806 putative catalytic motif [active] 941968007807 putative substrate binding site [chemical binding]; other site 941968007811 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 941968007813 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 941968007814 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 941968007816 1 probable transmembrane helix predicted for cbot01540 by TMHMM2.0 at aa 24-46 941968007819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 941968007820 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 941968007822 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 941968007824 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 941968007825 1 probable transmembrane helix predicted for cbot01543 by TMHMM2.0 at aa 7-26 941968007827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 941968007828 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968007829 catalytic residue [active] 941968007833 Protein of unknown function (DUF552); Region: DUF552; cl00775 941968007835 1 probable transmembrane helix predicted for cbot01545 by TMHMM2.0 at aa 4-26 941968007837 YGGT family; Region: YGGT; pfam02325 941968007839 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 941968007840 DivIVA protein; Region: DivIVA; pfam05103 941968007841 DivIVA domain; Region: DivI1A_domain; TIGR03544 941968007843 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 941968007844 active site 941968007845 dimer interface [polypeptide binding]; other site 941968007846 metal binding site [ion binding]; metal-binding site 941968007849 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 941968007850 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 941968007854 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 941968007855 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 941968007857 1 probable transmembrane helix predicted for cbot01552 by TMHMM2.0 at aa 12-34 941968007859 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 941968007860 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 941968007861 hinge; other site 941968007862 active site 941968007865 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 941968007867 lipoprotein signal peptidase; Provisional; Region: PRK14791 941968007868 lipoprotein signal peptidase; Provisional; Region: PRK14787 941968007870 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941968007871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968007872 RNA binding surface [nucleotide binding]; other site 941968007873 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941968007874 active site 941968007879 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 941968007880 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968007881 active site 941968007883 uracil transporter; Provisional; Region: PRK10720 941968007888 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 941968007889 active site 941968007890 putative catalytic site [active] 941968007891 phosphate binding site A [ion binding]; other site 941968007892 DNA binding site [nucleotide binding] 941968007893 metal binding site A [ion binding]; metal-binding site 941968007894 putative AP binding site [nucleotide binding]; other site 941968007895 putative metal binding site B [ion binding]; other site 941968007896 phosphate binding site B [ion binding]; other site 941968007898 1 probable transmembrane helix predicted for cbot01559 by TMHMM2.0 at aa 5-24 941968007899 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 941968007900 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 941968007901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941968007903 Carbonic anhydrase; Region: Pro_CA; smart00947 941968007904 active site clefts [active] 941968007905 zinc binding site [ion binding]; other site 941968007906 dimer interface [polypeptide binding]; other site 941968007908 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941968007909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941968007913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007914 dimer interface [polypeptide binding]; other site 941968007915 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941968007916 conserved gate region; other site 941968007917 putative PBP binding loops; other site 941968007918 ABC-ATPase subunit interface; other site 941968007920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968007921 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 941968007922 Walker A/P-loop; other site 941968007923 ATP binding site [chemical binding]; other site 941968007924 Q-loop/lid; other site 941968007925 ABC transporter signature motif; other site 941968007926 Walker B; other site 941968007927 D-loop; other site 941968007928 H-loop/switch region; other site 941968007929 1 probable transmembrane helix predicted for cbot01564 by TMHMM2.0 at aa 21-40 941968007932 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941968007933 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 941968007934 active site 941968007935 nucleophile elbow; other site 941968007938 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 941968007939 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 941968007942 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 941968007945 potential frameshift: common BLAST hit: gi|153935375|ref|YP_001387391.1| (Fe-S)-binding protein 941968007946 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 941968007949 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 941968007950 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 941968007951 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968007952 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 941968007955 1 probable transmembrane helix predicted for cbot01572 by TMHMM2.0 at aa 7-29 941968007957 potential frameshift: common BLAST hit: gi|226948829|ref|YP_002803920.1| uroporphyrinogen decarboxylase family protein 941968007958 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 941968007960 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 941968007962 1 probable transmembrane helix predicted for cbot01574 by TMHMM2.0 at aa 15-32 941968007963 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 941968007964 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 941968007965 B12 binding site [chemical binding]; other site 941968007966 cobalt ligand [ion binding]; other site 941968007968 1 probable transmembrane helix predicted for cbot01575 by TMHMM2.0 at aa 80-102 941968007970 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 941968007971 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 941968007975 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 941968007976 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 941968007982 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 941968007983 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941968007984 Walker A/P-loop; other site 941968007985 ATP binding site [chemical binding]; other site 941968007986 Q-loop/lid; other site 941968007987 ABC transporter signature motif; other site 941968007988 Walker B; other site 941968007989 D-loop; other site 941968007990 H-loop/switch region; other site 941968007991 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 941968007996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968007997 dimer interface [polypeptide binding]; other site 941968007998 conserved gate region; other site 941968007999 ABC-ATPase subunit interface; other site 941968008001 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941968008002 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941968008007 MORN repeat; Region: MORN; cl14787 941968008021 1 probable transmembrane helix predicted for cbot01581 by TMHMM2.0 at aa 15-37 941968008022 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941968008023 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 941968008024 active site 941968008025 FMN binding site [chemical binding]; other site 941968008026 substrate binding site [chemical binding]; other site 941968008027 putative catalytic residue [active] 941968008029 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 941968008030 dimer interface [polypeptide binding]; other site 941968008031 active site 941968008034 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941968008035 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 941968008036 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 941968008037 [2Fe-2S] cluster binding site [ion binding]; other site 941968008041 DNA topoisomerase III; Provisional; Region: PRK07726 941968008042 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 941968008043 active site 941968008044 putative interdomain interaction site [polypeptide binding]; other site 941968008045 putative metal-binding site [ion binding]; other site 941968008046 putative nucleotide binding site [chemical binding]; other site 941968008047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 941968008048 domain I; other site 941968008049 DNA binding groove [nucleotide binding] 941968008050 phosphate binding site [ion binding]; other site 941968008051 domain II; other site 941968008052 domain III; other site 941968008053 nucleotide binding site [chemical binding]; other site 941968008054 catalytic site [active] 941968008055 domain IV; other site 941968008063 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 941968008064 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 941968008065 Walker A/P-loop; other site 941968008066 ATP binding site [chemical binding]; other site 941968008067 Q-loop/lid; other site 941968008068 ABC transporter signature motif; other site 941968008069 Walker B; other site 941968008070 D-loop; other site 941968008071 H-loop/switch region; other site 941968008077 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 941968008078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941968008079 active site 941968008080 catalytic tetrad [active] 941968008081 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968008085 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 941968008086 putative deacylase active site [active] 941968008088 Protein of unknown function (DUF523); Region: DUF523; pfam04463 941968008090 potential frameshift: common BLAST hit: gi|384461910|ref|YP_005674505.1| carbohydrate uptake ABC transporter, CUT1 family, ATP-binding 941968008091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968008092 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 941968008093 Walker A/P-loop; other site 941968008094 ATP binding site [chemical binding]; other site 941968008095 Q-loop/lid; other site 941968008096 ABC transporter signature motif; other site 941968008097 Walker B; other site 941968008098 D-loop; other site 941968008099 H-loop/switch region; other site 941968008105 TOBE domain; Region: TOBE; pfam03459 941968008107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968008108 dimer interface [polypeptide binding]; other site 941968008109 conserved gate region; other site 941968008110 putative PBP binding loops; other site 941968008111 ABC-ATPase subunit interface; other site 941968008114 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941968008115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968008116 dimer interface [polypeptide binding]; other site 941968008117 conserved gate region; other site 941968008118 putative PBP binding loops; other site 941968008119 ABC-ATPase subunit interface; other site 941968008122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941968008123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941968008126 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 941968008127 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 941968008128 NAD binding site [chemical binding]; other site 941968008129 dimer interface [polypeptide binding]; other site 941968008130 substrate binding site [chemical binding]; other site 941968008131 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968008134 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941968008135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968008136 DNA-binding site [nucleotide binding]; DNA binding site 941968008137 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941968008142 1 probable transmembrane helix predicted for cbot01596 by TMHMM2.0 at aa 21-43 941968008145 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 941968008149 1 probable transmembrane helix predicted for cbot01597 by TMHMM2.0 at aa 12-34 941968008150 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 941968008151 gating phenylalanine in ion channel; other site 941968008154 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968008155 PAS domain S-box; Region: sensory_box; TIGR00229 941968008156 PAS domain; Region: PAS; smart00091 941968008157 putative active site [active] 941968008158 heme pocket [chemical binding]; other site 941968008159 PAS domain S-box; Region: sensory_box; TIGR00229 941968008160 PAS domain; Region: PAS_8; pfam13188 941968008161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968008162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968008163 metal binding site [ion binding]; metal-binding site 941968008164 active site 941968008165 I-site; other site 941968008166 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941968008167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968008168 Zn2+ binding site [ion binding]; other site 941968008169 Mg2+ binding site [ion binding]; other site 941968008178 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 941968008179 dimerization interface [polypeptide binding]; other site 941968008183 Cache domain; Region: Cache_1; pfam02743 941968008184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968008185 dimerization interface [polypeptide binding]; other site 941968008186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968008187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968008188 dimer interface [polypeptide binding]; other site 941968008189 putative CheW interface [polypeptide binding]; other site 941968008193 MarR family; Region: MarR_2; pfam12802 941968008195 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 941968008196 1 probable transmembrane helix predicted for cbot01604 by TMHMM2.0 at aa 47-66 941968008197 Predicted transcriptional regulators [Transcription]; Region: COG1733 941968008198 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941968008200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941968008201 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941968008202 active site 941968008203 metal binding site [ion binding]; metal-binding site 941968008205 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 941968008206 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941968008207 DNA binding site [nucleotide binding] 941968008208 active site 941968008210 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 941968008211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968008212 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968008213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968008215 1 probable transmembrane helix predicted for cbot01608 by TMHMM2.0 at aa 12-31 941968008220 hypothetical protein; Provisional; Region: PRK02399 941968008221 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 941968008228 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 941968008230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968008231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968008232 non-specific DNA binding site [nucleotide binding]; other site 941968008233 salt bridge; other site 941968008234 sequence-specific DNA binding site [nucleotide binding]; other site 941968008239 1 probable transmembrane helix predicted for cbot01612 by TMHMM2.0 at aa 13-35 941968008240 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968008241 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968008244 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941968008245 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 941968008248 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 941968008249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968008250 putative substrate translocation pore; other site 941968008257 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 941968008258 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 941968008259 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 941968008264 HDOD domain; Region: HDOD; pfam08668 941968008265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968008266 Zn2+ binding site [ion binding]; other site 941968008267 Mg2+ binding site [ion binding]; other site 941968008269 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941968008270 sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116 941968008271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968008272 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968008273 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 941968008274 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968008279 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941968008280 active site 941968008281 potential frameshift: common BLAST hit: gi|170760934|ref|YP_001786969.1| chloramphenicol acetyltransferase 941968008282 Chloramphenicol acetyltransferase; Region: CAT; cl02008 941968008284 Chloramphenicol acetyltransferase; Region: CAT; cl02008 941968008285 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 941968008286 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941968008287 ligand binding site [chemical binding]; other site 941968008288 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941968008290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941968008291 dimerization interface [polypeptide binding]; other site 941968008292 DNA binding residues [nucleotide binding] 941968008295 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 941968008296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 941968008299 Predicted transcriptional regulator [Transcription]; Region: COG2378 941968008300 HTH domain; Region: HTH_11; pfam08279 941968008301 WYL domain; Region: WYL; pfam13280 941968008303 1 probable transmembrane helix predicted for cbot01627 by TMHMM2.0 at aa 7-29 941968008305 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 941968008310 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968008312 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 941968008313 active site 941968008315 1 probable transmembrane helix predicted for cbot01630 by TMHMM2.0 at aa 10-32 941968008316 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 941968008317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968008318 FeS/SAM binding site; other site 941968008321 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 941968008322 active site 941968008324 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 941968008325 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 941968008326 Ligand Binding Site [chemical binding]; other site 941968008328 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968008329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968008330 dimer interface [polypeptide binding]; other site 941968008331 putative CheW interface [polypeptide binding]; other site 941968008336 Protein of unknown function (DUF975); Region: DUF975; cl10504 941968008340 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941968008341 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 941968008342 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941968008345 1 probable transmembrane helix predicted for cbot01637 by TMHMM2.0 at aa 20-42 941968008347 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 941968008348 intersubunit interface [polypeptide binding]; other site 941968008349 active site 941968008350 catalytic residue [active] 941968008353 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941968008354 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 941968008355 substrate binding site [chemical binding]; other site 941968008356 dimer interface [polypeptide binding]; other site 941968008357 ATP binding site [chemical binding]; other site 941968008359 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 941968008360 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941968008361 dimer interface [polypeptide binding]; other site 941968008362 motif 1; other site 941968008363 active site 941968008364 motif 2; other site 941968008365 motif 3; other site 941968008368 1 probable transmembrane helix predicted for cbot01640 by TMHMM2.0 at aa 31-48 941968008369 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 941968008370 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 941968008373 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 941968008374 histidinol dehydrogenase; Region: hisD; TIGR00069 941968008375 NAD binding site [chemical binding]; other site 941968008376 dimerization interface [polypeptide binding]; other site 941968008377 product binding site; other site 941968008378 substrate binding site [chemical binding]; other site 941968008379 zinc binding site [ion binding]; other site 941968008380 catalytic residues [active] 941968008382 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 941968008383 putative active site pocket [active] 941968008384 4-fold oligomerization interface [polypeptide binding]; other site 941968008385 metal binding residues [ion binding]; metal-binding site 941968008386 3-fold/trimer interface [polypeptide binding]; other site 941968008388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 941968008390 1 probable transmembrane helix predicted for cbot01645 by TMHMM2.0 at aa 15-37 941968008391 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 941968008392 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 941968008393 catalytic residues [active] 941968008395 potential frameshift: common BLAST hit: gi|384461960|ref|YP_005674555.1| histidinol-phosphate transaminase 941968008396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968008397 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 941968008398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968008399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968008400 homodimer interface [polypeptide binding]; other site 941968008401 catalytic residue [active] 941968008403 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 941968008404 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941968008405 substrate binding site [chemical binding]; other site 941968008406 glutamase interaction surface [polypeptide binding]; other site 941968008408 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 941968008410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 941968008411 metal binding site [ion binding]; metal-binding site 941968008413 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 941968008417 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941968008418 CPxP motif; other site 941968008420 putative inner membrane protein; Provisional; Region: PRK11099 941968008421 putative inner membrane protein; Provisional; Region: PRK11099 941968008423 1 probable transmembrane helix predicted for cbot01655 by TMHMM2.0 at aa 23-45 941968008424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968008425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968008426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941968008427 dimerization interface [polypeptide binding]; other site 941968008431 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968008432 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968008434 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 941968008435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968008436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968008437 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941968008438 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941968008439 active site residue [active] 941968008448 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 941968008449 Sulphur transport; Region: Sulf_transp; pfam04143 941968008452 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 941968008453 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 941968008454 Walker A/P-loop; other site 941968008455 ATP binding site [chemical binding]; other site 941968008456 Q-loop/lid; other site 941968008457 ABC transporter signature motif; other site 941968008458 Walker B; other site 941968008459 D-loop; other site 941968008460 H-loop/switch region; other site 941968008464 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 941968008465 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968008467 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 941968008468 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968008469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968008470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968008471 active site 941968008472 phosphorylation site [posttranslational modification] 941968008473 intermolecular recognition site; other site 941968008474 dimerization interface [polypeptide binding]; other site 941968008475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968008476 DNA binding site [nucleotide binding] 941968008481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968008482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 941968008483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968008484 dimer interface [polypeptide binding]; other site 941968008485 phosphorylation site [posttranslational modification] 941968008486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968008487 ATP binding site [chemical binding]; other site 941968008488 Mg2+ binding site [ion binding]; other site 941968008489 G-X-G motif; other site 941968008496 arginine deiminase; Provisional; Region: PRK01388 941968008497 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 941968008500 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 941968008503 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 941968008504 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 941968008506 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 941968008509 HD domain; Region: HD_3; pfam13023 941968008512 YmaF family; Region: YmaF; pfam12788 941968008513 potential frameshift: common BLAST hit: gi|384461982|ref|YP_005674577.1| Snf2 family helicase 941968008514 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 941968008516 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941968008517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968008518 ATP binding site [chemical binding]; other site 941968008519 putative Mg++ binding site [ion binding]; other site 941968008520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968008521 nucleotide binding region [chemical binding]; other site 941968008522 ATP-binding site [chemical binding]; other site 941968008529 potential frameshift: common BLAST hit: gi|153934781|ref|YP_001387484.1| RelA/SpoT domain-containing protein 941968008530 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 941968008532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968008533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968008536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968008537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968008538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968008539 Walker A/P-loop; other site 941968008540 ATP binding site [chemical binding]; other site 941968008541 Q-loop/lid; other site 941968008542 ABC transporter signature motif; other site 941968008543 Walker B; other site 941968008544 D-loop; other site 941968008545 H-loop/switch region; other site 941968008552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968008553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968008554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968008555 Walker A/P-loop; other site 941968008556 ATP binding site [chemical binding]; other site 941968008557 Q-loop/lid; other site 941968008558 ABC transporter signature motif; other site 941968008559 Walker B; other site 941968008560 D-loop; other site 941968008561 H-loop/switch region; other site 941968008566 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941968008567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941968008568 DNA binding site [nucleotide binding] 941968008569 domain linker motif; other site 941968008570 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 941968008571 putative dimerization interface [polypeptide binding]; other site 941968008572 putative ligand binding site [chemical binding]; other site 941968008576 1 probable transmembrane helix predicted for cbot01681 by TMHMM2.0 at aa 28-50 941968008578 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 941968008579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968008580 nucleotide binding site [chemical binding]; other site 941968008585 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 941968008586 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 941968008587 Ca binding site [ion binding]; other site 941968008588 active site 941968008589 catalytic site [active] 941968008592 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968008593 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 941968008594 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968008595 active site turn [active] 941968008596 phosphorylation site [posttranslational modification] 941968008602 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 941968008603 putative catalytic site [active] 941968008604 putative metal binding site [ion binding]; other site 941968008605 putative phosphate binding site [ion binding]; other site 941968008607 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 941968008608 Domain of unknown function DUF; Region: DUF204; pfam02659 941968008612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 941968008613 1 probable transmembrane helix predicted for cbot01687 by TMHMM2.0 at aa 20-42 941968008615 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 941968008617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968008618 G-X-G motif; other site 941968008620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968008621 active site 941968008622 phosphorylation site [posttranslational modification] 941968008623 intermolecular recognition site; other site 941968008624 dimerization interface [polypeptide binding]; other site 941968008627 1 probable transmembrane helix predicted for cbot01691 by TMHMM2.0 at aa 20-42 941968008628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968008629 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 941968008630 putative substrate translocation pore; other site 941968008635 1 probable transmembrane helix predicted for cbot01693 by TMHMM2.0 at aa 10-32 941968008636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968008637 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941968008638 active site 941968008639 motif I; other site 941968008640 motif II; other site 941968008641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968008643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941968008644 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941968008645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941968008649 1 probable transmembrane helix predicted for cbot01695 by TMHMM2.0 at aa 30-52 941968008651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968008652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968008653 DNA binding residues [nucleotide binding] 941968008656 YvrJ protein family; Region: YvrJ; pfam12841 941968008657 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 941968008658 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 941968008659 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 941968008660 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 941968008661 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 941968008662 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 941968008669 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 941968008670 FAD binding site [chemical binding]; other site 941968008672 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 941968008674 potential frameshift: common BLAST hit: gi|226948951|ref|YP_002804042.1| 5-methyltetrahydrofolate:homocysteine S-methyltransferase 941968008675 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 941968008676 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 941968008677 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 941968008678 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 941968008679 substrate binding pocket [chemical binding]; other site 941968008680 dimer interface [polypeptide binding]; other site 941968008681 inhibitor binding site; inhibition site 941968008682 B12 binding domain; Region: B12-binding_2; smart01018 941968008689 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 941968008690 B12 binding site [chemical binding]; other site 941968008695 potential frameshift: common BLAST hit: gi|384462006|ref|YP_005674601.1| RNA polymerase sigma-70 factor family 941968008696 RNA polymerase factor sigma-70; Validated; Region: PRK06811 941968008698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 941968008700 1 probable transmembrane helix predicted for cbot01705 by TMHMM2.0 at aa 10-32 941968008702 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 941968008703 GAF domain; Region: GAF; pfam01590 941968008704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968008705 Walker A motif; other site 941968008706 ATP binding site [chemical binding]; other site 941968008707 Walker B motif; other site 941968008708 arginine finger; other site 941968008709 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968008713 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 941968008715 1 probable transmembrane helix predicted for cbot01710 by TMHMM2.0 at aa 36-58 941968008716 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941968008717 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941968008718 tetramer interface [polypeptide binding]; other site 941968008719 TPP-binding site [chemical binding]; other site 941968008720 heterodimer interface [polypeptide binding]; other site 941968008721 phosphorylation loop region [posttranslational modification] 941968008724 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941968008725 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941968008726 alpha subunit interface [polypeptide binding]; other site 941968008727 TPP binding site [chemical binding]; other site 941968008728 heterodimer interface [polypeptide binding]; other site 941968008729 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941968008735 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 941968008738 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941968008739 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941968008740 E3 interaction surface; other site 941968008741 lipoyl attachment site [posttranslational modification]; other site 941968008742 e3 binding domain; Region: E3_binding; pfam02817 941968008743 e3 binding domain; Region: E3_binding; pfam02817 941968008744 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941968008752 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 941968008753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968008754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968008755 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941968008764 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 941968008765 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941968008766 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 941968008769 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 941968008770 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 941968008771 Walker A/P-loop; other site 941968008772 ATP binding site [chemical binding]; other site 941968008773 Q-loop/lid; other site 941968008774 ABC transporter signature motif; other site 941968008775 Walker B; other site 941968008776 D-loop; other site 941968008777 H-loop/switch region; other site 941968008778 FOG: CBS domain [General function prediction only]; Region: COG0517 941968008779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 941968008789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968008790 ABC-ATPase subunit interface; other site 941968008791 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 941968008795 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 941968008796 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 941968008797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968008798 catalytic residue [active] 941968008801 homoserine kinase; Provisional; Region: PRK01212 941968008802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941968008806 aspartate kinase; Reviewed; Region: PRK09034 941968008807 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 941968008808 nucleotide binding site [chemical binding]; other site 941968008809 substrate binding site [chemical binding]; other site 941968008810 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 941968008811 allosteric regulatory residue; other site 941968008812 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 941968008815 1 probable transmembrane helix predicted for cbot01721 by TMHMM2.0 at aa 20-42 941968008816 homoserine dehydrogenase; Provisional; Region: PRK06349 941968008817 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941968008818 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941968008819 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 941968008825 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941968008826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968008827 putative active site [active] 941968008828 heme pocket [chemical binding]; other site 941968008829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968008830 Walker A motif; other site 941968008831 ATP binding site [chemical binding]; other site 941968008832 Walker B motif; other site 941968008833 arginine finger; other site 941968008834 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968008842 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941968008843 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 941968008844 putative active site [active] 941968008845 metal binding site [ion binding]; metal-binding site 941968008848 1 probable transmembrane helix predicted for cbot01724 by TMHMM2.0 at aa 25-44 941968008849 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 941968008850 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 941968008851 FAD binding pocket [chemical binding]; other site 941968008852 FAD binding motif [chemical binding]; other site 941968008853 phosphate binding motif [ion binding]; other site 941968008854 beta-alpha-beta structure motif; other site 941968008855 NAD binding pocket [chemical binding]; other site 941968008856 Iron coordination center [ion binding]; other site 941968008861 putative oxidoreductase; Provisional; Region: PRK12831 941968008862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968008870 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941968008871 PAS domain; Region: PAS; smart00091 941968008872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968008873 Walker A motif; other site 941968008874 ATP binding site [chemical binding]; other site 941968008875 Walker B motif; other site 941968008876 arginine finger; other site 941968008877 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968008882 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 941968008883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 941968008886 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 941968008887 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 941968008891 1 probable transmembrane helix predicted for cbot01731 by TMHMM2.0 at aa 38-60 941968008892 1 probable transmembrane helix predicted for cbot01733 by TMHMM2.0 at aa 39-61 941968008893 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 941968008895 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 941968008897 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 941968008902 Hemerythrin-like domain; Region: Hr-like; cd12108 941968008903 Fe binding site [ion binding]; other site 941968008907 potential frameshift: common BLAST hit: gi|384462036|ref|YP_005674631.1| alanine racemase 941968008908 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 941968008909 catalytic residue [active] 941968008911 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 941968008912 dimer interface [polypeptide binding]; other site 941968008913 active site 941968008914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968008915 substrate binding site [chemical binding]; other site 941968008916 catalytic residues [active] 941968008919 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968008920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968008921 dimer interface [polypeptide binding]; other site 941968008922 putative CheW interface [polypeptide binding]; other site 941968008923 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 941968008927 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941968008929 Protein of unknown function (DUF975); Region: DUF975; cl10504 941968008931 short chain dehydrogenase; Provisional; Region: PRK06701 941968008932 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 941968008933 NAD binding site [chemical binding]; other site 941968008934 metal binding site [ion binding]; metal-binding site 941968008935 active site 941968008937 KWG Leptospira; Region: KWG; pfam07656 941968008938 KWG Leptospira; Region: KWG; pfam07656 941968008939 KWG Leptospira; Region: KWG; pfam07656 941968008944 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 941968008945 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941968008946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968008947 ATP binding site [chemical binding]; other site 941968008948 putative Mg++ binding site [ion binding]; other site 941968008949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968008950 nucleotide binding region [chemical binding]; other site 941968008951 ATP-binding site [chemical binding]; other site 941968008957 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 941968008958 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 941968008959 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 941968008960 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 941968008963 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 941968008964 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 941968008969 potential frameshift: common BLAST hit: gi|170755119|ref|YP_001781303.1| peptide/opine/nickel uptake ABC transporter permease 941968008970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941968008971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941968008972 dimer interface [polypeptide binding]; other site 941968008973 conserved gate region; other site 941968008974 ABC-ATPase subunit interface; other site 941968008977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941968008978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941968008980 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 941968008981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968008982 dimer interface [polypeptide binding]; other site 941968008983 conserved gate region; other site 941968008984 putative PBP binding loops; other site 941968008985 ABC-ATPase subunit interface; other site 941968008989 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 941968008990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968008991 Walker A/P-loop; other site 941968008992 ATP binding site [chemical binding]; other site 941968008993 Q-loop/lid; other site 941968008994 ABC transporter signature motif; other site 941968008995 Walker B; other site 941968008996 D-loop; other site 941968008997 H-loop/switch region; other site 941968008998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941968008999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968009000 Walker A/P-loop; other site 941968009001 ATP binding site [chemical binding]; other site 941968009002 Q-loop/lid; other site 941968009003 ABC transporter signature motif; other site 941968009004 Walker B; other site 941968009005 D-loop; other site 941968009006 H-loop/switch region; other site 941968009015 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941968009016 active site 941968009017 catalytic site [active] 941968009018 substrate binding site [chemical binding]; other site 941968009022 Predicted secreted protein [Function unknown]; Region: COG4086 941968009023 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 941968009028 Predicted secreted protein [Function unknown]; Region: COG4086 941968009029 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941968009030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968009031 S-adenosylmethionine binding site [chemical binding]; other site 941968009032 1 probable transmembrane helix predicted for cbot01763 by TMHMM2.0 at aa 20-42 941968009034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968009035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968009036 putative substrate translocation pore; other site 941968009039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968009040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968009042 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941968009044 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 941968009045 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 941968009046 putative substrate binding site [chemical binding]; other site 941968009047 putative ATP binding site [chemical binding]; other site 941968009050 1 probable transmembrane helix predicted for cbot01767 by TMHMM2.0 at aa 25-47 941968009051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968009052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968009053 putative substrate translocation pore; other site 941968009057 1 probable transmembrane helix predicted for cbot01771 by TMHMM2.0 at aa 23-45 941968009058 Putative amidase domain; Region: Amidase_6; pfam12671 941968009060 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 941968009061 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941968009062 substrate binding site [chemical binding]; other site 941968009063 ATP binding site [chemical binding]; other site 941968009065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968009066 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941968009067 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941968009071 1 probable transmembrane helix predicted for cbot01774 by TMHMM2.0 at aa 25-47 941968009073 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941968009074 DNA-binding site [nucleotide binding]; DNA binding site 941968009075 RNA-binding motif; other site 941968009078 Cache domain; Region: Cache_1; pfam02743 941968009079 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941968009080 HAMP domain; Region: HAMP; pfam00672 941968009081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968009082 dimer interface [polypeptide binding]; other site 941968009083 putative CheW interface [polypeptide binding]; other site 941968009089 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 941968009090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009091 Pecanex protein (C-terminus); Region: Pecanex_C; pfam05041 941968009092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009093 ABC transporter; Region: ABC_tran_2; pfam12848 941968009094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009099 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 941968009100 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941968009101 4Fe-4S binding domain; Region: Fer4_6; pfam12837 941968009106 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941968009107 Response regulator receiver domain; Region: Response_reg; pfam00072 941968009108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009109 active site 941968009110 phosphorylation site [posttranslational modification] 941968009111 intermolecular recognition site; other site 941968009112 dimerization interface [polypeptide binding]; other site 941968009117 1 probable transmembrane helix predicted for cbot01780 by TMHMM2.0 at aa 10-32 941968009119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941968009120 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941968009121 ATP binding site [chemical binding]; other site 941968009122 putative Mg++ binding site [ion binding]; other site 941968009123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968009124 nucleotide binding region [chemical binding]; other site 941968009125 ATP-binding site [chemical binding]; other site 941968009131 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 941968009132 S1 domain; Region: S1_2; pfam13509 941968009133 S1 domain; Region: S1_2; pfam13509 941968009134 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 941968009135 RNA binding site [nucleotide binding]; other site 941968009139 1 probable transmembrane helix predicted for cbot01782 by TMHMM2.0 at aa 21-43 941968009142 potential frameshift: common BLAST hit: gi|237795191|ref|YP_002862743.1| ATP-dependent RNA helicase DbpA 941968009143 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941968009144 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941968009145 ATP binding site [chemical binding]; other site 941968009146 Mg++ binding site [ion binding]; other site 941968009147 motif III; other site 941968009150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968009151 nucleotide binding region [chemical binding]; other site 941968009152 ATP-binding site [chemical binding]; other site 941968009153 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 941968009158 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 941968009164 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009165 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009166 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009167 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 941968009168 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009169 Leucine rich repeat; Region: LRR_8; pfam13855 941968009170 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009171 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009172 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968009173 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 941968009198 potential frameshift: common BLAST hit: gi|237795194|ref|YP_002862746.1| mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 941968009199 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 941968009200 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 941968009202 1 probable transmembrane helix predicted for cbot01788 by TMHMM2.0 at aa 27-49 941968009205 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 941968009206 Ferritin-like domain; Region: Ferritin; pfam00210 941968009207 ferroxidase diiron center [ion binding]; other site 941968009209 1 probable transmembrane helix predicted for cbot01789 by TMHMM2.0 at aa 24-46 941968009210 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941968009211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009212 active site 941968009213 phosphorylation site [posttranslational modification] 941968009214 intermolecular recognition site; other site 941968009215 dimerization interface [polypeptide binding]; other site 941968009216 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 941968009221 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 941968009222 1 probable transmembrane helix predicted for cbot01791 by TMHMM2.0 at aa 12-34 941968009224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 941968009225 Nucleoside recognition; Region: Gate; pfam07670 941968009228 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941968009230 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941968009232 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 941968009233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968009234 active site 941968009235 DNA binding site [nucleotide binding] 941968009236 Int/Topo IB signature motif; other site 941968009240 1 probable transmembrane helix predicted for cbot01796 by TMHMM2.0 at aa 22-44 941968009242 LexA repressor; Validated; Region: PRK00215 941968009243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941968009244 putative Zn2+ binding site [ion binding]; other site 941968009245 putative DNA binding site [nucleotide binding]; other site 941968009246 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941968009247 Catalytic site [active] 941968009251 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 941968009252 Aluminium resistance protein; Region: Alum_res; pfam06838 941968009255 bacterial Hfq-like; Region: Hfq; cd01716 941968009256 hexamer interface [polypeptide binding]; other site 941968009257 Sm1 motif; other site 941968009258 RNA binding site [nucleotide binding]; other site 941968009259 Sm2 motif; other site 941968009261 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 941968009262 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 941968009264 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 941968009265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968009266 ATP binding site [chemical binding]; other site 941968009267 Mg2+ binding site [ion binding]; other site 941968009268 G-X-G motif; other site 941968009269 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 941968009270 ATP binding site [chemical binding]; other site 941968009271 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 941968009279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 941968009280 MutS domain I; Region: MutS_I; pfam01624 941968009281 MutS domain II; Region: MutS_II; pfam05188 941968009282 MutS domain III; Region: MutS_III; pfam05192 941968009283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 941968009284 Walker A/P-loop; other site 941968009285 ATP binding site [chemical binding]; other site 941968009286 Q-loop/lid; other site 941968009287 ABC transporter signature motif; other site 941968009288 Walker B; other site 941968009289 D-loop; other site 941968009290 H-loop/switch region; other site 941968009298 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 941968009299 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941968009300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968009301 FeS/SAM binding site; other site 941968009302 TRAM domain; Region: TRAM; pfam01938 941968009310 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 941968009311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968009312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968009313 homodimer interface [polypeptide binding]; other site 941968009314 catalytic residue [active] 941968009316 aspartate aminotransferase; Provisional; Region: PRK07568 941968009317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968009318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968009319 homodimer interface [polypeptide binding]; other site 941968009320 catalytic residue [active] 941968009322 1 probable transmembrane helix predicted for cbot01806 by TMHMM2.0 at aa 28-50 941968009324 potential frameshift: common BLAST hit: gi|153936063|ref|YP_001387602.1| acetyltransferase 941968009326 potential frameshift: common BLAST hit: gi|153935267|ref|YP_001387603.1| spore coat protein 941968009327 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 941968009328 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 941968009329 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 941968009330 LytB protein; Region: LYTB; cl00507 941968009331 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 941968009332 RNA binding site [nucleotide binding]; other site 941968009333 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 941968009334 RNA binding site [nucleotide binding]; other site 941968009335 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 941968009336 RNA binding site [nucleotide binding]; other site 941968009337 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 941968009338 RNA binding site [nucleotide binding]; other site 941968009339 domain interface; other site 941968009350 cytidylate kinase; Provisional; Region: cmk; PRK00023 941968009351 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 941968009352 CMP-binding site; other site 941968009353 The sites determining sugar specificity; other site 941968009355 flavoprotein, HI0933 family; Region: TIGR00275 941968009356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968009360 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 941968009361 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941968009362 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 941968009363 NAD(P) binding site [chemical binding]; other site 941968009369 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968009370 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968009371 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968009372 putative active site [active] 941968009375 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941968009376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968009377 RNA binding surface [nucleotide binding]; other site 941968009378 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 941968009379 active site 941968009383 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 941968009385 1 probable transmembrane helix predicted for cbot01817 by TMHMM2.0 at aa 20-39 941968009387 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 941968009390 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 941968009391 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 941968009392 DXD motif; other site 941968009395 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 941968009398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968009399 dimerization interface [polypeptide binding]; other site 941968009400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968009401 dimer interface [polypeptide binding]; other site 941968009402 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 941968009403 putative CheW interface [polypeptide binding]; other site 941968009408 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 941968009409 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 941968009412 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 941968009414 1 probable transmembrane helix predicted for cbot01823 by TMHMM2.0 at aa 7-26 941968009416 potential frameshift: common BLAST hit: gi|153935362|ref|YP_001387618.1| carbon-nitrogen family hydrolase 941968009417 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 941968009418 putative active site [active] 941968009419 catalytic triad [active] 941968009420 dimer interface [polypeptide binding]; other site 941968009422 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 941968009424 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941968009425 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941968009426 TrkA-C domain; Region: TrkA_C; pfam02080 941968009430 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 941968009432 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968009433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968009434 Coenzyme A binding pocket [chemical binding]; other site 941968009436 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941968009437 active site residue [active] 941968009442 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 941968009444 1 probable transmembrane helix predicted for cbot01831 by TMHMM2.0 at aa 5-27 941968009445 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 941968009446 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968009447 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 941968009448 Putative Fe-S cluster; Region: FeS; cl17515 941968009449 PAS domain; Region: PAS_9; pfam13426 941968009450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968009451 putative active site [active] 941968009452 heme pocket [chemical binding]; other site 941968009457 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941968009460 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 941968009461 4Fe-4S binding domain; Region: Fer4; pfam00037 941968009462 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 941968009463 Putative Fe-S cluster; Region: FeS; cl17515 941968009464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968009465 putative active site [active] 941968009470 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 941968009471 ATP binding site [chemical binding]; other site 941968009472 dimerization interface [polypeptide binding]; other site 941968009475 Hydrogenase formation hypA family; Region: HypD; pfam01924 941968009476 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 941968009478 HupF/HypC family; Region: HupF_HypC; pfam01455 941968009480 potential frameshift: common BLAST hit: gi|153936241|ref|YP_001387633.1| [NiFe] hydrogenase maturation protein HypF 941968009481 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 941968009482 HypF finger; Region: zf-HYPF; pfam07503 941968009483 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 941968009486 Acylphosphatase; Region: Acylphosphatase; pfam00708 941968009488 1 probable transmembrane helix predicted for cbot01840 by TMHMM2.0 at aa 13-35 941968009489 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 941968009492 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 941968009493 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 941968009498 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 941968009499 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 941968009501 TraX protein; Region: TraX; pfam05857 941968009503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 941968009504 1 probable transmembrane helix predicted for cbot01848 by TMHMM2.0 at aa 4-26 941968009505 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941968009506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968009508 Walker A/P-loop; other site 941968009509 ATP binding site [chemical binding]; other site 941968009510 Q-loop/lid; other site 941968009511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009512 ABC transporter signature motif; other site 941968009513 ABC transporter; Region: ABC_tran_2; pfam12848 941968009514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968009519 1 probable transmembrane helix predicted for cbot01849 by TMHMM2.0 at aa 25-47 941968009521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941968009522 catalytic loop [active] 941968009523 iron binding site [ion binding]; other site 941968009524 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 941968009525 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 941968009526 4Fe-4S binding domain; Region: Fer4; pfam00037 941968009527 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 941968009528 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 941968009537 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 941968009538 dimer interface [polypeptide binding]; other site 941968009539 [2Fe-2S] cluster binding site [ion binding]; other site 941968009540 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 941968009541 SLBB domain; Region: SLBB; pfam10531 941968009542 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 941968009543 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 941968009544 4Fe-4S binding domain; Region: Fer4; pfam00037 941968009551 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 941968009552 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 941968009553 putative dimer interface [polypeptide binding]; other site 941968009554 [2Fe-2S] cluster binding site [ion binding]; other site 941968009557 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941968009560 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 941968009564 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941968009566 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941968009568 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941968009569 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941968009570 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 941968009573 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 941968009576 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 941968009578 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 941968009580 1 probable transmembrane helix predicted for cbot01860 by TMHMM2.0 at aa 56-78 941968009582 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 941968009585 potential frameshift: common BLAST hit: gi|226949102|ref|YP_002804193.1| serine-type D-Ala-D-Ala carboxypeptidase 941968009586 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 941968009589 1 probable transmembrane helix predicted for cbot01863 by TMHMM2.0 at aa 10-32 941968009590 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941968009591 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941968009595 EcsC protein family; Region: EcsC; pfam12787 941968009597 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 941968009598 putative catalytic site [active] 941968009599 putative metal binding site [ion binding]; other site 941968009600 putative phosphate binding site [ion binding]; other site 941968009602 1 probable transmembrane helix predicted for cbot01866 by TMHMM2.0 at aa 21-43 941968009603 potential frameshift: common BLAST hit: gi|153937290|ref|YP_001387661.1| pyrimidine-nucleoside phosphorylase 941968009604 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 941968009606 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941968009607 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 941968009612 purine nucleoside phosphorylase; Provisional; Region: PRK08202 941968009614 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 941968009615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968009616 active site 941968009617 Int/Topo IB signature motif; other site 941968009618 DNA binding site [nucleotide binding] 941968009619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968009620 active site 941968009621 Int/Topo IB signature motif; other site 941968009622 DNA binding site [nucleotide binding] 941968009625 1 probable transmembrane helix predicted for cbot01873 by TMHMM2.0 at aa 7-29 941968009626 stage II sporulation protein M; Region: spo_II_M; TIGR02831 941968009628 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 941968009629 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 941968009630 dimer interface [polypeptide binding]; other site 941968009631 ADP-ribose binding site [chemical binding]; other site 941968009632 active site 941968009633 nudix motif; other site 941968009634 metal binding site [ion binding]; metal-binding site 941968009636 1 probable transmembrane helix predicted for cbot01875 by TMHMM2.0 at aa 13-35 941968009637 inner membrane transporter YjeM; Provisional; Region: PRK15238 941968009640 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941968009641 NlpC/P60 family; Region: NLPC_P60; pfam00877 941968009643 1 probable transmembrane helix predicted for cbot01877 by TMHMM2.0 at aa 7-29 941968009645 1 probable transmembrane helix predicted for cbot01878 by TMHMM2.0 at aa 33-55 941968009647 1 probable transmembrane helix predicted for cbot01879 by TMHMM2.0 at aa 102-124 941968009649 potential frameshift: common BLAST hit: gi|148379710|ref|YP_001254251.1| bacteriophage endolysin (N-acetylmuramoyl-L-alanine amidase) 941968009650 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 941968009651 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968009653 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968009654 active site 941968009655 metal binding site [ion binding]; metal-binding site 941968009657 1 probable transmembrane helix predicted for cbot01883 by TMHMM2.0 at aa 13-35 941968009658 AAA domain; Region: AAA_18; pfam13238 941968009659 1 probable transmembrane helix predicted for cbot01884 by TMHMM2.0 at aa 7-29 941968009661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968009665 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 941968009666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009667 active site 941968009668 phosphorylation site [posttranslational modification] 941968009669 intermolecular recognition site; other site 941968009670 dimerization interface [polypeptide binding]; other site 941968009671 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 941968009676 potential frameshift: common BLAST hit: gi|153934727|ref|YP_001387672.1| stage IV sporulation protein B 941968009677 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 941968009679 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 941968009683 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 941968009684 conserved cys residue [active] 941968009686 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 941968009687 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941968009688 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941968009691 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 941968009692 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941968009693 homodimer interface [polypeptide binding]; other site 941968009694 substrate-cofactor binding pocket; other site 941968009695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968009696 catalytic residue [active] 941968009698 1 probable transmembrane helix predicted for cbot01893 by TMHMM2.0 at aa 19-41 941968009701 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 941968009702 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941968009703 Walker A/P-loop; other site 941968009704 ATP binding site [chemical binding]; other site 941968009705 Q-loop/lid; other site 941968009706 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941968009707 ABC transporter signature motif; other site 941968009708 Walker B; other site 941968009709 D-loop; other site 941968009710 H-loop/switch region; other site 941968009712 arginine repressor; Provisional; Region: argR; PRK00441 941968009713 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 941968009714 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 941968009717 1 probable transmembrane helix predicted for cbot01895 by TMHMM2.0 at aa 20-42 941968009718 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 941968009719 ATP-NAD kinase; Region: NAD_kinase; pfam01513 941968009723 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 941968009724 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 941968009727 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 941968009728 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 941968009729 TPP-binding site; other site 941968009730 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941968009731 PYR/PP interface [polypeptide binding]; other site 941968009732 dimer interface [polypeptide binding]; other site 941968009733 TPP binding site [chemical binding]; other site 941968009734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941968009740 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941968009741 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941968009742 substrate binding pocket [chemical binding]; other site 941968009743 chain length determination region; other site 941968009744 substrate-Mg2+ binding site; other site 941968009745 catalytic residues [active] 941968009746 aspartate-rich region 1; other site 941968009747 active site lid residues [active] 941968009748 aspartate-rich region 2; other site 941968009750 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 941968009752 1 probable transmembrane helix predicted for cbot01902 by TMHMM2.0 at aa 15-37 941968009753 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 941968009754 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 941968009755 generic binding surface I; other site 941968009756 generic binding surface II; other site 941968009759 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 941968009761 1 probable transmembrane helix predicted for cbot01904 by TMHMM2.0 at aa 65-84 941968009762 Asp23 family; Region: Asp23; pfam03780 941968009764 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 941968009766 potential frameshift: common BLAST hit: gi|384462230|ref|YP_005674825.1| stage III sporulation protein AG 941968009767 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 941968009768 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 941968009771 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 941968009774 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 941968009777 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 941968009779 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 941968009781 potential frameshift: common BLAST hit: gi|226949193|ref|YP_002804284.1| stage III sporulation protein AA 941968009782 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 941968009783 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 941968009784 elongation factor P; Validated; Region: PRK00529 941968009785 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 941968009786 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 941968009787 RNA binding site [nucleotide binding]; other site 941968009788 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 941968009789 RNA binding site [nucleotide binding]; other site 941968009793 1 probable transmembrane helix predicted for cbot01918 by TMHMM2.0 at aa 10-32 941968009795 Dehydroquinase class II; Region: DHquinase_II; pfam01220 941968009796 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 941968009797 trimer interface [polypeptide binding]; other site 941968009798 active site 941968009799 dimer interface [polypeptide binding]; other site 941968009801 1 probable transmembrane helix predicted for cbot01919 by TMHMM2.0 at aa 114-136 941968009802 shikimate kinase; Reviewed; Region: aroK; PRK00131 941968009803 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 941968009804 ADP binding site [chemical binding]; other site 941968009805 magnesium binding site [ion binding]; other site 941968009806 putative shikimate binding site; other site 941968009808 1 probable transmembrane helix predicted for cbot01922 by TMHMM2.0 at aa 23-42 941968009810 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 941968009811 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 941968009812 1 probable transmembrane helix predicted for cbot01924 by TMHMM2.0 at aa 7-29 941968009813 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 941968009815 1 probable transmembrane helix predicted for cbot01925 by TMHMM2.0 at aa 10-32 941968009816 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 941968009817 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941968009819 1 probable transmembrane helix predicted for cbot01927 by TMHMM2.0 at aa 13-35 941968009821 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 941968009822 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941968009823 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941968009826 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 941968009827 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 941968009828 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941968009829 Walker A motif; other site 941968009830 ATP binding site [chemical binding]; other site 941968009831 Walker B motif; other site 941968009835 potential frameshift: common BLAST hit: gi|226949209|ref|YP_002804300.1| putative lipoprotein 941968009836 potential frameshift: common BLAST hit: gi|226949209|ref|YP_002804300.1| putative lipoprotein 941968009838 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 941968009839 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941968009840 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941968009844 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 941968009845 Domain of unknown function (DUF814); Region: DUF814; pfam05670 941968009848 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 941968009849 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 941968009850 dimerization interface 3.5A [polypeptide binding]; other site 941968009851 active site 941968009855 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 941968009856 nucleotide binding site/active site [active] 941968009857 HIT family signature motif; other site 941968009858 catalytic residue [active] 941968009860 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 941968009861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968009862 catalytic residue [active] 941968009864 potential frameshift: common BLAST hit: gi|226949217|ref|YP_002804308.1| methyl-accepting chemotaxis protein 941968009865 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941968009866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968009867 dimerization interface [polypeptide binding]; other site 941968009868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968009869 dimer interface [polypeptide binding]; other site 941968009870 putative CheW interface [polypeptide binding]; other site 941968009878 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941968009879 1 probable transmembrane helix predicted for cbot01942 by TMHMM2.0 at aa 9-28 941968009880 clostripain; Region: clostrip; TIGR02806 941968009884 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 941968009887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968009888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009889 active site 941968009890 phosphorylation site [posttranslational modification] 941968009891 intermolecular recognition site; other site 941968009892 dimerization interface [polypeptide binding]; other site 941968009893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968009894 DNA binding site [nucleotide binding] 941968009899 potential frameshift: common BLAST hit: gi|170754265|ref|YP_001781484.1| sensor histidine kinase 941968009901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968009902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968009903 dimer interface [polypeptide binding]; other site 941968009904 phosphorylation site [posttranslational modification] 941968009905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968009906 ATP binding site [chemical binding]; other site 941968009907 Mg2+ binding site [ion binding]; other site 941968009908 G-X-G motif; other site 941968009911 1 probable transmembrane helix predicted for cbot01947 by TMHMM2.0 at aa 4-26 941968009916 methionine sulfoxide reductase A; Provisional; Region: PRK14054 941968009918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009919 active site 941968009920 phosphorylation site [posttranslational modification] 941968009921 intermolecular recognition site; other site 941968009922 dimerization interface [polypeptide binding]; other site 941968009923 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941968009924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009925 active site 941968009926 phosphorylation site [posttranslational modification] 941968009927 intermolecular recognition site; other site 941968009928 dimerization interface [polypeptide binding]; other site 941968009934 potential frameshift: common BLAST hit: gi|384462267|ref|YP_005674862.1| sensor histidine kinase 941968009935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968009936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968009937 ATP binding site [chemical binding]; other site 941968009938 Mg2+ binding site [ion binding]; other site 941968009939 G-X-G motif; other site 941968009942 1 probable transmembrane helix predicted for cbot01950 by TMHMM2.0 at aa 15-37 941968009943 potential frameshift: common BLAST hit: gi|153934767|ref|YP_001387725.1| sensor histidine kinase 941968009944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968009945 dimerization interface [polypeptide binding]; other site 941968009946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968009947 dimer interface [polypeptide binding]; other site 941968009948 phosphorylation site [posttranslational modification] 941968009953 1 probable transmembrane helix predicted for cbot01952 by TMHMM2.0 at aa 13-35 941968009955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968009956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968009957 active site 941968009958 phosphorylation site [posttranslational modification] 941968009959 intermolecular recognition site; other site 941968009960 dimerization interface [polypeptide binding]; other site 941968009961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968009962 DNA binding site [nucleotide binding] 941968009967 potential frameshift: common BLAST hit: gi|170754889|ref|YP_001781491.1| ABC transporter permease 941968009968 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941968009969 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968009971 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 941968009972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968009973 Walker A/P-loop; other site 941968009974 ATP binding site [chemical binding]; other site 941968009975 Q-loop/lid; other site 941968009976 ABC transporter signature motif; other site 941968009977 Walker B; other site 941968009978 D-loop; other site 941968009979 H-loop/switch region; other site 941968009983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968009984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968009985 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 941968009986 Walker A/P-loop; other site 941968009987 ATP binding site [chemical binding]; other site 941968009988 Q-loop/lid; other site 941968009989 ABC transporter signature motif; other site 941968009990 Walker B; other site 941968009991 D-loop; other site 941968009992 H-loop/switch region; other site 941968009996 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968009997 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 941968009998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968009999 Walker A/P-loop; other site 941968010000 ATP binding site [chemical binding]; other site 941968010001 Q-loop/lid; other site 941968010002 ABC transporter signature motif; other site 941968010003 Walker B; other site 941968010004 D-loop; other site 941968010005 H-loop/switch region; other site 941968010013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968010014 MarR family; Region: MarR; pfam01047 941968010015 1 probable transmembrane helix predicted for cbot01961 by TMHMM2.0 at aa 20-42 941968010018 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941968010019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968010020 Coenzyme A binding pocket [chemical binding]; other site 941968010022 hypothetical protein; Provisional; Region: PRK08328 941968010023 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 941968010024 ATP binding site [chemical binding]; other site 941968010025 substrate interface [chemical binding]; other site 941968010026 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 941968010027 substrate interface [chemical binding]; other site 941968010029 1 probable transmembrane helix predicted for cbot01963 by TMHMM2.0 at aa 33-50 941968010032 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 941968010033 MoaE interaction surface [polypeptide binding]; other site 941968010034 MoeB interaction surface [polypeptide binding]; other site 941968010035 thiocarboxylated glycine; other site 941968010037 1 probable transmembrane helix predicted for cbot01965 by TMHMM2.0 at aa 38-60 941968010038 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 941968010039 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 941968010040 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 941968010044 1 probable transmembrane helix predicted for cbot01966 by TMHMM2.0 at aa 28-50 941968010047 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 941968010048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968010049 putative active site [active] 941968010050 heme pocket [chemical binding]; other site 941968010051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968010052 Walker A motif; other site 941968010053 ATP binding site [chemical binding]; other site 941968010054 Walker B motif; other site 941968010055 arginine finger; other site 941968010056 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968010060 1 probable transmembrane helix predicted for cbot01967 by TMHMM2.0 at aa 15-37 941968010064 MOSC domain; Region: MOSC; pfam03473 941968010066 1 probable transmembrane helix predicted for cbot01968 by TMHMM2.0 at aa 13-35 941968010067 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 941968010068 trimer interface [polypeptide binding]; other site 941968010069 dimer interface [polypeptide binding]; other site 941968010070 putative active site [active] 941968010072 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 941968010073 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968010074 FeS/SAM binding site; other site 941968010075 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 941968010079 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 941968010080 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941968010081 dimer interface [polypeptide binding]; other site 941968010082 putative functional site; other site 941968010083 putative MPT binding site; other site 941968010084 PBP superfamily domain; Region: PBP_like; pfam12727 941968010091 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941968010092 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941968010093 dimer interface [polypeptide binding]; other site 941968010094 putative functional site; other site 941968010095 putative MPT binding site; other site 941968010100 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 941968010101 MPT binding site; other site 941968010102 trimer interface [polypeptide binding]; other site 941968010106 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 941968010107 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941968010108 Walker A/P-loop; other site 941968010109 ATP binding site [chemical binding]; other site 941968010110 Q-loop/lid; other site 941968010111 ABC transporter signature motif; other site 941968010112 Walker B; other site 941968010113 D-loop; other site 941968010114 H-loop/switch region; other site 941968010117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968010118 dimer interface [polypeptide binding]; other site 941968010119 conserved gate region; other site 941968010120 putative PBP binding loops; other site 941968010121 ABC-ATPase subunit interface; other site 941968010123 PBP superfamily domain; Region: PBP_like_2; pfam12849 941968010127 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 941968010128 putative efflux protein, MATE family; Region: matE; TIGR00797 941968010131 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941968010133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968010134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968010135 Walker A/P-loop; other site 941968010136 ATP binding site [chemical binding]; other site 941968010137 Q-loop/lid; other site 941968010138 ABC transporter signature motif; other site 941968010139 Walker B; other site 941968010140 D-loop; other site 941968010141 H-loop/switch region; other site 941968010145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 941968010146 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 941968010147 FtsX-like permease family; Region: FtsX; pfam02687 941968010151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968010152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968010153 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 941968010154 Walker A/P-loop; other site 941968010155 ATP binding site [chemical binding]; other site 941968010156 Q-loop/lid; other site 941968010157 ABC transporter signature motif; other site 941968010158 Walker B; other site 941968010159 D-loop; other site 941968010160 H-loop/switch region; other site 941968010168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968010169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968010170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968010171 Walker A/P-loop; other site 941968010172 ATP binding site [chemical binding]; other site 941968010173 Q-loop/lid; other site 941968010174 ABC transporter signature motif; other site 941968010175 Walker B; other site 941968010176 D-loop; other site 941968010177 H-loop/switch region; other site 941968010184 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 941968010185 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968010186 DNA binding residues [nucleotide binding] 941968010187 dimer interface [polypeptide binding]; other site 941968010188 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 941968010192 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968010193 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968010195 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 941968010197 1 probable transmembrane helix predicted for cbot01987 by TMHMM2.0 at aa 29-46 941968010198 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968010207 M6 family metalloprotease domain; Region: M6dom_TIGR03296 941968010208 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 941968010214 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 941968010215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968010216 Walker A motif; other site 941968010217 ATP binding site [chemical binding]; other site 941968010218 Walker B motif; other site 941968010219 arginine finger; other site 941968010222 1 probable transmembrane helix predicted for cbot01990 by TMHMM2.0 at aa 37-59 941968010226 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 941968010228 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941968010229 homotrimer interaction site [polypeptide binding]; other site 941968010230 putative active site [active] 941968010233 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 941968010234 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941968010235 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941968010241 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 941968010242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968010243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968010244 homodimer interface [polypeptide binding]; other site 941968010245 catalytic residue [active] 941968010248 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 941968010253 1 probable transmembrane helix predicted for cbot01997 by TMHMM2.0 at aa 5-27 941968010255 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 941968010256 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968010257 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 941968010258 Leucine-rich repeats; other site 941968010259 Substrate binding site [chemical binding]; other site 941968010260 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968010261 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968010262 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968010273 M6 family metalloprotease domain; Region: M6dom_TIGR03296 941968010276 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 941968010277 dimerization interface [polypeptide binding]; other site 941968010278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968010279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968010280 dimer interface [polypeptide binding]; other site 941968010281 phosphorylation site [posttranslational modification] 941968010282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968010283 ATP binding site [chemical binding]; other site 941968010284 Mg2+ binding site [ion binding]; other site 941968010285 G-X-G motif; other site 941968010294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968010295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968010296 active site 941968010297 phosphorylation site [posttranslational modification] 941968010298 intermolecular recognition site; other site 941968010299 dimerization interface [polypeptide binding]; other site 941968010300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968010301 DNA binding site [nucleotide binding] 941968010305 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 941968010307 1 probable transmembrane helix predicted for cbot02003 by TMHMM2.0 at aa 10-32 941968010309 potential frameshift: common BLAST hit: gi|226949269|ref|YP_002804360.1| putative ABC transporter permease 941968010310 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 941968010312 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 941968010313 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941968010314 Walker A/P-loop; other site 941968010315 ATP binding site [chemical binding]; other site 941968010316 Q-loop/lid; other site 941968010317 ABC transporter signature motif; other site 941968010318 Walker B; other site 941968010319 D-loop; other site 941968010320 H-loop/switch region; other site 941968010321 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941968010322 Walker A/P-loop; other site 941968010323 ATP binding site [chemical binding]; other site 941968010324 Q-loop/lid; other site 941968010325 ABC transporter signature motif; other site 941968010326 Walker B; other site 941968010327 D-loop; other site 941968010328 H-loop/switch region; other site 941968010334 1 probable transmembrane helix predicted for cbot02006 by TMHMM2.0 at aa 12-34 941968010336 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 941968010340 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 941968010341 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 941968010342 dimer interface [polypeptide binding]; other site 941968010343 active site 941968010344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968010345 substrate binding site [chemical binding]; other site 941968010346 catalytic residue [active] 941968010348 Spore germination protein; Region: Spore_permease; cl17796 941968010350 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 941968010352 Spore germination protein; Region: Spore_permease; cl17796 941968010355 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 941968010356 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 941968010359 Spore germination protein; Region: Spore_permease; cl17796 941968010360 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 941968010362 1 probable transmembrane helix predicted for cbot02013 by TMHMM2.0 at aa 40-62 941968010363 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 941968010365 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 941968010366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968010367 FeS/SAM binding site; other site 941968010368 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 941968010369 1 probable transmembrane helix predicted for cbot02015 by TMHMM2.0 at aa 27-44 941968010371 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 941968010374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968010375 binding surface 941968010376 TPR repeat; Region: TPR_11; pfam13414 941968010377 TPR motif; other site 941968010378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968010379 binding surface 941968010380 TPR repeat; Region: TPR_11; pfam13414 941968010381 TPR motif; other site 941968010387 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941968010388 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941968010389 TrkA-C domain; Region: TrkA_C; pfam02080 941968010395 heat shock protein 90; Provisional; Region: PRK05218 941968010396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968010397 ATP binding site [chemical binding]; other site 941968010398 Mg2+ binding site [ion binding]; other site 941968010399 G-X-G motif; other site 941968010406 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 941968010407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968010408 Walker A/P-loop; other site 941968010409 ATP binding site [chemical binding]; other site 941968010410 Q-loop/lid; other site 941968010411 ABC transporter signature motif; other site 941968010412 Walker B; other site 941968010413 D-loop; other site 941968010414 H-loop/switch region; other site 941968010417 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 941968010418 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968010419 active site turn [active] 941968010420 phosphorylation site [posttranslational modification] 941968010421 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968010426 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 941968010427 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 941968010428 Ca binding site [ion binding]; other site 941968010429 active site 941968010430 catalytic site [active] 941968010433 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 941968010434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968010435 DNA-binding site [nucleotide binding]; DNA binding site 941968010436 UTRA domain; Region: UTRA; pfam07702 941968010440 1 probable transmembrane helix predicted for cbot02023 by TMHMM2.0 at aa 60-79 941968010443 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941968010444 active site 941968010445 phosphorylation site [posttranslational modification] 941968010447 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 941968010448 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 941968010449 active site 941968010450 P-loop; other site 941968010451 phosphorylation site [posttranslational modification] 941968010452 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 941968010457 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 941968010458 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 941968010459 putative substrate binding site [chemical binding]; other site 941968010460 putative ATP binding site [chemical binding]; other site 941968010462 1 probable transmembrane helix predicted for cbot02026 by TMHMM2.0 at aa 25-47 941968010463 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 941968010464 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 941968010465 intersubunit interface [polypeptide binding]; other site 941968010466 active site 941968010467 zinc binding site [ion binding]; other site 941968010468 Na+ binding site [ion binding]; other site 941968010472 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941968010473 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941968010474 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941968010475 putative active site [active] 941968010478 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 941968010480 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941968010481 homotrimer interaction site [polypeptide binding]; other site 941968010482 putative active site [active] 941968010484 1 probable transmembrane helix predicted for cbot02030 by TMHMM2.0 at aa 5-24 941968010486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968010487 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941968010488 FeS/SAM binding site; other site 941968010492 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 941968010493 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 941968010494 dimer interface [polypeptide binding]; other site 941968010495 active site 941968010496 metal binding site [ion binding]; metal-binding site 941968010500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968010501 dimerization interface [polypeptide binding]; other site 941968010502 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968010503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968010504 dimer interface [polypeptide binding]; other site 941968010505 putative CheW interface [polypeptide binding]; other site 941968010511 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 941968010512 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 941968010513 dimer interface [polypeptide binding]; other site 941968010514 active site 941968010515 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968010516 substrate binding site [chemical binding]; other site 941968010517 catalytic residue [active] 941968010520 ATP cone domain; Region: ATP-cone; pfam03477 941968010522 potential frameshift: common BLAST hit: gi|237795435|ref|YP_002862987.1| oxidoreductase family protein 941968010523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941968010524 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941968010527 putative oxidoreductase; Provisional; Region: PRK11579 941968010529 adenine phosphoribosyltransferase; Provisional; Region: PRK07322 941968010531 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941968010536 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968010537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968010538 metal binding site [ion binding]; metal-binding site 941968010539 active site 941968010540 I-site; other site 941968010543 1 probable transmembrane helix predicted for cbot02043 by TMHMM2.0 at aa 13-35 941968010544 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 941968010546 PAS domain; Region: PAS; smart00091 941968010547 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 941968010548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968010549 Walker A motif; other site 941968010550 ATP binding site [chemical binding]; other site 941968010551 Walker B motif; other site 941968010552 arginine finger; other site 941968010555 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941968010556 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941968010557 ATP binding site [chemical binding]; other site 941968010558 Mg++ binding site [ion binding]; other site 941968010559 motif III; other site 941968010560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968010561 nucleotide binding region [chemical binding]; other site 941968010562 ATP-binding site [chemical binding]; other site 941968010564 1 probable transmembrane helix predicted for cbot02046 by TMHMM2.0 at aa 10-32 941968010569 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941968010570 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941968010574 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968010575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968010576 DNA-binding site [nucleotide binding]; DNA binding site 941968010577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968010578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968010579 homodimer interface [polypeptide binding]; other site 941968010580 catalytic residue [active] 941968010584 1 probable transmembrane helix predicted for cbot02048 by TMHMM2.0 at aa 21-43 941968010585 potential frameshift: common BLAST hit: gi|170759171|ref|YP_001787406.1| aspartate aminotransferase 941968010586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968010587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968010588 homodimer interface [polypeptide binding]; other site 941968010589 catalytic residue [active] 941968010591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968010592 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941968010593 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941968010594 Walker A/P-loop; other site 941968010595 ATP binding site [chemical binding]; other site 941968010596 Q-loop/lid; other site 941968010597 ABC transporter signature motif; other site 941968010598 Walker B; other site 941968010599 D-loop; other site 941968010600 H-loop/switch region; other site 941968010601 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941968010602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968010603 Q-loop/lid; other site 941968010604 ABC transporter signature motif; other site 941968010605 Walker B; other site 941968010606 D-loop; other site 941968010607 H-loop/switch region; other site 941968010612 1 probable transmembrane helix predicted for cbot02052 by TMHMM2.0 at aa 5-27 941968010614 potential frameshift: common BLAST hit: gi|384462353|ref|YP_005674948.1| amino acid ABC transporter permease 941968010615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968010616 putative PBP binding loops; other site 941968010617 dimer interface [polypeptide binding]; other site 941968010618 ABC-ATPase subunit interface; other site 941968010620 1 probable transmembrane helix predicted for cbot02053 by TMHMM2.0 at aa 130-152 941968010621 1 probable transmembrane helix predicted for cbot02054 by TMHMM2.0 at aa 20-40 941968010622 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941968010623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941968010624 substrate binding pocket [chemical binding]; other site 941968010625 membrane-bound complex binding site; other site 941968010626 hinge residues; other site 941968010632 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 941968010635 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 941968010636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968010637 catalytic residue [active] 941968010639 1 probable transmembrane helix predicted for cbot02057 by TMHMM2.0 at aa 29-51 941968010640 Chloramphenicol acetyltransferase; Region: CAT; cl02008 941968010641 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 941968010643 1 probable transmembrane helix predicted for cbot02058 by TMHMM2.0 at aa 21-40 941968010644 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 941968010646 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 941968010648 AAA domain; Region: AAA_12; pfam13087 941968010649 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941968010650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968010651 sequence-specific DNA binding site [nucleotide binding]; other site 941968010652 salt bridge; other site 941968010654 POT family; Region: PTR2; cl17359 941968010655 POT family; Region: PTR2; cl17359 941968010660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968010661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968010662 putative substrate translocation pore; other site 941968010663 POT family; Region: PTR2; cl17359 941968010666 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941968010667 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941968010668 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 941968010669 active site 941968010671 1 probable transmembrane helix predicted for cbot02068 by TMHMM2.0 at aa 41-63 941968010673 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 941968010676 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 941968010677 Na2 binding site [ion binding]; other site 941968010678 putative substrate binding site 1 [chemical binding]; other site 941968010679 Na binding site 1 [ion binding]; other site 941968010680 putative substrate binding site 2 [chemical binding]; other site 941968010685 1 probable transmembrane helix predicted for cbot02072 by TMHMM2.0 at aa 16-35 941968010686 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 941968010687 nucleophilic elbow; other site 941968010688 catalytic triad; other site 941968010692 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 941968010693 putative FMN binding site [chemical binding]; other site 941968010696 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 941968010697 metal ion-dependent adhesion site (MIDAS); other site 941968010700 1 probable transmembrane helix predicted for cbot02076 by TMHMM2.0 at aa 137-159 941968010702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941968010703 myosin-cross-reactive antigen; Provisional; Region: PRK13977 941968010705 1 probable transmembrane helix predicted for cbot02078 by TMHMM2.0 at aa 34-56 941968010707 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 941968010708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968010710 1 probable transmembrane helix predicted for cbot02079 by TMHMM2.0 at aa 4-26 941968010711 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 941968010713 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 941968010714 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 941968010715 catalytic residues [active] 941968010716 catalytic nucleophile [active] 941968010720 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 941968010721 active site 941968010724 1 probable transmembrane helix predicted for cbot02083 by TMHMM2.0 at aa 46-68 941968010725 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 941968010726 active site 941968010728 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 941968010729 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 941968010730 putative trimer interface [polypeptide binding]; other site 941968010731 putative CoA binding site [chemical binding]; other site 941968010734 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 941968010735 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 941968010736 inhibitor-cofactor binding pocket; inhibition site 941968010737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968010738 catalytic residue [active] 941968010740 1 probable transmembrane helix predicted for cbot02086 by TMHMM2.0 at aa 10-32 941968010742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 941968010743 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 941968010744 active site 941968010746 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 941968010747 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 941968010748 substrate binding site; other site 941968010749 metal-binding site 941968010750 Oligomer interface; other site 941968010751 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 941968010755 1 probable transmembrane helix predicted for cbot02088 by TMHMM2.0 at aa 15-37 941968010756 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 941968010757 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 941968010758 NAD binding site [chemical binding]; other site 941968010759 substrate binding site [chemical binding]; other site 941968010760 homodimer interface [polypeptide binding]; other site 941968010761 active site 941968010763 1 probable transmembrane helix predicted for cbot02090 by TMHMM2.0 at aa 59-81 941968010764 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 941968010765 PGAP1-like protein; Region: PGAP1; pfam07819 941968010768 VanZ like family; Region: VanZ; pfam04892 941968010770 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 941968010771 glycosyltransferase, MGT family; Region: MGT; TIGR01426 941968010772 active site 941968010773 TDP-binding site; other site 941968010774 acceptor substrate-binding pocket; other site 941968010775 homodimer interface [polypeptide binding]; other site 941968010778 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 941968010779 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 941968010781 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968010782 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968010783 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941968010785 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 941968010787 cytosine deaminase; Provisional; Region: PRK09230 941968010788 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 941968010789 active site 941968010791 1 probable transmembrane helix predicted for cbot02098 by TMHMM2.0 at aa 32-54 941968010795 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 941968010796 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 941968010797 Na binding site [ion binding]; other site 941968010798 putative substrate binding site [chemical binding]; other site 941968010802 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941968010803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968010804 FeS/SAM binding site; other site 941968010805 1 probable transmembrane helix predicted for cbot02101 by TMHMM2.0 at aa 37-59 941968010807 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 941968010808 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 941968010809 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 941968010810 putative active site [active] 941968010811 putative NTP binding site [chemical binding]; other site 941968010812 putative nucleic acid binding site [nucleotide binding]; other site 941968010816 1 probable transmembrane helix predicted for cbot02106 by TMHMM2.0 at aa 10-32 941968010817 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 941968010818 AAA-like domain; Region: AAA_10; pfam12846 941968010819 Domain of unknown function DUF87; Region: DUF87; pfam01935 941968010821 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 941968010824 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 941968010825 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 941968010828 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 941968010829 active site 941968010830 1 probable transmembrane helix predicted for cbot02111 by TMHMM2.0 at aa 13-35 941968010831 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 941968010832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968010833 NAD(P) binding site [chemical binding]; other site 941968010834 active site 941968010836 1 probable transmembrane helix predicted for cbot02112 by TMHMM2.0 at aa 15-37 941968010837 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941968010838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941968010839 active site 941968010840 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941968010841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941968010842 active site 941968010845 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941968010846 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 941968010847 active site 941968010848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968010849 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941968010854 potential frameshift: common BLAST hit: gi|170761450|ref|YP_001787488.1| tetracycline resistance protein 941968010855 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 941968010857 1 probable transmembrane helix predicted for cbot02115 by TMHMM2.0 at aa 5-27 941968010858 potential frameshift: common BLAST hit: gi|226949385|ref|YP_002804476.1| tetracycline resistance protein TetP 941968010859 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 941968010860 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941968010861 G5 box; other site 941968010862 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 941968010863 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 941968010868 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941968010869 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 941968010870 G1 box; other site 941968010871 GTP/Mg2+ binding site [chemical binding]; other site 941968010872 G2 box; other site 941968010873 Switch I region; other site 941968010874 G3 box; other site 941968010875 Switch II region; other site 941968010876 G4 box; other site 941968010878 Viral enhancin protein; Region: Enhancin; pfam03272 941968010879 Peptidase M60-like family; Region: M60-like; pfam13402 941968010880 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 941968010881 aromatic chitin/cellulose binding site residues [chemical binding]; other site 941968010886 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 941968010887 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968010888 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968010894 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 941968010895 putative homodimer interface [polypeptide binding]; other site 941968010896 putative homotetramer interface [polypeptide binding]; other site 941968010897 putative metal binding site [ion binding]; other site 941968010898 putative homodimer-homodimer interface [polypeptide binding]; other site 941968010900 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 941968010901 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 941968010902 Hexamer interface [polypeptide binding]; other site 941968010903 Putative hexagonal pore residue; other site 941968010906 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 941968010907 Propanediol utilisation protein PduL; Region: PduL; pfam06130 941968010908 Propanediol utilisation protein PduL; Region: PduL; pfam06130 941968010912 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 941968010913 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 941968010914 putative catalytic cysteine [active] 941968010918 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 941968010919 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 941968010920 Hexamer interface [polypeptide binding]; other site 941968010921 Hexagonal pore residue; other site 941968010924 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 941968010925 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 941968010927 1 probable transmembrane helix predicted for cbot02125 by TMHMM2.0 at aa 10-32 941968010929 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 941968010930 Hexamer/Pentamer interface [polypeptide binding]; other site 941968010931 central pore; other site 941968010934 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 941968010935 putative hexamer interface [polypeptide binding]; other site 941968010936 putative hexagonal pore; other site 941968010939 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 941968010940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968010941 nucleotide binding site [chemical binding]; other site 941968010942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941968010943 nucleotide binding site [chemical binding]; other site 941968010946 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 941968010947 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 941968010948 G1 box; other site 941968010949 GTP/Mg2+ binding site [chemical binding]; other site 941968010950 Switch I region; other site 941968010951 G3 box; other site 941968010952 Switch II region; other site 941968010953 G4 box; other site 941968010954 G5 box; other site 941968010956 1 probable transmembrane helix predicted for cbot02130 by TMHMM2.0 at aa 7-29 941968010957 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 941968010958 putative hexamer interface [polypeptide binding]; other site 941968010959 putative hexagonal pore; other site 941968010962 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 941968010963 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968010965 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 941968010966 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 941968010967 dimer interface [polypeptide binding]; other site 941968010968 active site 941968010969 glycine loop; other site 941968010974 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 941968010975 putative catalytic cysteine [active] 941968010977 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 941968010978 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 941968010979 Hexamer interface [polypeptide binding]; other site 941968010980 Hexagonal pore residue; other site 941968010983 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 941968010984 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 941968010985 Hexamer interface [polypeptide binding]; other site 941968010986 Hexagonal pore residue; other site 941968010990 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 941968010994 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 941968010995 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968010996 DNA binding residues [nucleotide binding] 941968010997 drug binding residues [chemical binding]; other site 941968010998 dimer interface [polypeptide binding]; other site 941968010999 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 941968011005 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941968011006 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 941968011007 putative active site [active] 941968011008 metal binding site [ion binding]; metal-binding site 941968011010 1 probable transmembrane helix predicted for cbot02142 by TMHMM2.0 at aa 27-49 941968011013 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 941968011014 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 941968011019 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941968011020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968011021 putative substrate translocation pore; other site 941968011024 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941968011025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968011026 DNA-binding site [nucleotide binding]; DNA binding site 941968011027 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941968011034 MarR family; Region: MarR_2; pfam12802 941968011035 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 941968011038 1 probable transmembrane helix predicted for cbot02147 by TMHMM2.0 at aa 5-27 941968011039 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 941968011041 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 941968011042 Helix-turn-helix domain; Region: HTH_17; pfam12728 941968011043 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 941968011044 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 941968011045 active site 941968011046 catalytic site [active] 941968011049 1 probable transmembrane helix predicted for cbot02152 by TMHMM2.0 at aa 20-42 941968011050 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 941968011051 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941968011052 active site 941968011059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968011060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 941968011061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968011062 ATP binding site [chemical binding]; other site 941968011063 Mg2+ binding site [ion binding]; other site 941968011064 G-X-G motif; other site 941968011068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968011069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968011070 active site 941968011071 phosphorylation site [posttranslational modification] 941968011072 intermolecular recognition site; other site 941968011073 dimerization interface [polypeptide binding]; other site 941968011074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968011075 DNA binding site [nucleotide binding] 941968011080 1 probable transmembrane helix predicted for cbot02155 by TMHMM2.0 at aa 13-35 941968011083 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 941968011084 Zn binding site [ion binding]; other site 941968011086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968011087 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 941968011088 Walker A/P-loop; other site 941968011089 ATP binding site [chemical binding]; other site 941968011090 Q-loop/lid; other site 941968011091 ABC transporter signature motif; other site 941968011092 Walker B; other site 941968011093 D-loop; other site 941968011094 H-loop/switch region; other site 941968011100 putative oxidoreductase; Provisional; Region: PRK11445 941968011102 1 probable transmembrane helix predicted for cbot02160 by TMHMM2.0 at aa 36-58 941968011103 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 941968011105 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941968011106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 941968011107 NAD(P) binding site [chemical binding]; other site 941968011110 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 941968011111 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941968011112 Metal-binding active site; metal-binding site 941968011114 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 941968011115 active site 941968011116 dimer interface [polypeptide binding]; other site 941968011117 metal binding site [ion binding]; metal-binding site 941968011121 FtsX-like permease family; Region: FtsX; pfam02687 941968011122 FtsX-like permease family; Region: FtsX; pfam02687 941968011126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968011127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941968011128 Walker A/P-loop; other site 941968011129 ATP binding site [chemical binding]; other site 941968011130 Q-loop/lid; other site 941968011131 ABC transporter signature motif; other site 941968011132 Walker B; other site 941968011133 D-loop; other site 941968011134 H-loop/switch region; other site 941968011139 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 941968011140 HTH domain; Region: HTH_11; pfam08279 941968011141 HTH domain; Region: HTH_11; pfam08279 941968011142 PRD domain; Region: PRD; pfam00874 941968011143 PRD domain; Region: PRD; pfam00874 941968011144 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 941968011145 active site 941968011146 P-loop; other site 941968011147 phosphorylation site [posttranslational modification] 941968011148 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941968011149 active site 941968011150 phosphorylation site [posttranslational modification] 941968011158 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 941968011162 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 941968011163 active site 941968011164 P-loop; other site 941968011165 phosphorylation site [posttranslational modification] 941968011167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941968011168 active site 941968011169 phosphorylation site [posttranslational modification] 941968011171 1 probable transmembrane helix predicted for cbot02172 by TMHMM2.0 at aa 48-70 941968011173 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 941968011174 active site 941968011175 intersubunit interactions; other site 941968011176 catalytic residue [active] 941968011178 1 probable transmembrane helix predicted for cbot02173 by TMHMM2.0 at aa 15-37 941968011182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941968011183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941968011185 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941968011186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968011187 NAD(P) binding site [chemical binding]; other site 941968011188 active site 941968011190 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 941968011191 trimer interface [polypeptide binding]; other site 941968011192 active site 941968011193 substrate binding site [chemical binding]; other site 941968011194 CoA binding site [chemical binding]; other site 941968011196 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 941968011197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968011198 POT family; Region: PTR2; cl17359 941968011200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968011201 S-adenosylmethionine binding site [chemical binding]; other site 941968011205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968011206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968011207 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 941968011212 1 probable transmembrane helix predicted for cbot02183 by TMHMM2.0 at aa 15-37 941968011214 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941968011215 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941968011216 phosphate binding site [ion binding]; other site 941968011217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941968011218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968011222 1 probable transmembrane helix predicted for cbot02185 by TMHMM2.0 at aa 45-67 941968011229 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941968011230 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 941968011231 DNA binding residues [nucleotide binding] 941968011232 dimer interface [polypeptide binding]; other site 941968011235 1 probable transmembrane helix predicted for cbot02186 by TMHMM2.0 at aa 15-37 941968011236 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 941968011239 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 941968011242 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336 941968011243 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 941968011245 1 probable transmembrane helix predicted for cbot02191 by TMHMM2.0 at aa 27-49 941968011250 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 941968011251 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 941968011253 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 941968011255 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 941968011256 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 941968011259 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 941968011260 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 941968011266 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941968011269 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941968011270 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941968011272 1 probable transmembrane helix predicted for cbot02200 by TMHMM2.0 at aa 28-50 941968011274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968011275 DNA-binding site [nucleotide binding]; DNA binding site 941968011276 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968011277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968011278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968011279 homodimer interface [polypeptide binding]; other site 941968011280 catalytic residue [active] 941968011284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941968011285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941968011286 active site 941968011288 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 941968011289 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 941968011290 NADP binding site [chemical binding]; other site 941968011291 active site 941968011292 regulatory binding site [polypeptide binding]; other site 941968011294 1 probable transmembrane helix predicted for cbot02203 by TMHMM2.0 at aa 5-27 941968011295 MarR family; Region: MarR_2; cl17246 941968011296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968011299 Staygreen protein; Region: Staygreen; pfam12638 941968011300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 941968011301 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 941968011302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941968011304 1 probable transmembrane helix predicted for cbot02206 by TMHMM2.0 at aa 15-37 941968011307 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941968011309 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 941968011310 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941968011311 active site 941968011312 ATP binding site [chemical binding]; other site 941968011313 substrate binding site [chemical binding]; other site 941968011314 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941968011315 substrate binding site [chemical binding]; other site 941968011316 activation loop (A-loop); other site 941968011317 activation loop (A-loop); other site 941968011320 1 probable transmembrane helix predicted for cbot02210 by TMHMM2.0 at aa 2-24 941968011321 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 941968011322 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968011325 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 941968011326 Uncharacterized membrane protein [Function unknown]; Region: COG3949 941968011327 Protein of unknown function (DUF3776); Region: DUF3776; pfam12618 941968011331 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941968011332 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941968011333 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941968011338 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941968011339 Ligand binding site [chemical binding]; other site 941968011340 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941968011344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941968011345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941968011346 active site 941968011350 1 probable transmembrane helix predicted for cbot02215 by TMHMM2.0 at aa 20-42 941968011354 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 941968011355 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968011359 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 941968011360 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968011362 1 probable transmembrane helix predicted for cbot02217 by TMHMM2.0 at aa 34-56 941968011363 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941968011364 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941968011367 1 probable transmembrane helix predicted for cbot02218 by TMHMM2.0 at aa 21-43 941968011369 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968011370 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 941968011373 1 probable transmembrane helix predicted for cbot02221 by TMHMM2.0 at aa 27-49 941968011375 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968011376 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 941968011378 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968011379 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968011380 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968011381 nucleotide binding site [chemical binding]; other site 941968011382 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968011386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968011387 dimer interface [polypeptide binding]; other site 941968011388 putative CheW interface [polypeptide binding]; other site 941968011389 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 941968011390 dimer interface [polypeptide binding]; other site 941968011391 FMN binding site [chemical binding]; other site 941968011393 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 941968011394 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 941968011395 active site 941968011398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968011399 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941968011400 Coenzyme A binding pocket [chemical binding]; other site 941968011402 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941968011403 active site 941968011405 GntP family permease; Region: GntP_permease; pfam02447 941968011406 fructuronate transporter; Provisional; Region: PRK10034; cl15264 941968011411 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 941968011412 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 941968011414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 941968011417 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941968011418 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941968011419 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941968011425 CAAX protease self-immunity; Region: Abi; pfam02517 941968011428 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941968011429 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941968011430 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941968011432 1 probable transmembrane helix predicted for cbot02233 by TMHMM2.0 at aa 12-34 941968011436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968011437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968011438 WHG domain; Region: WHG; pfam13305 941968011440 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968011441 1 probable transmembrane helix predicted for cbot02236 by TMHMM2.0 at aa 32-54 941968011442 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 941968011443 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 941968011447 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941968011448 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 941968011449 putative NAD(P) binding site [chemical binding]; other site 941968011450 catalytic Zn binding site [ion binding]; other site 941968011456 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 941968011457 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 941968011458 ACS interaction site; other site 941968011459 CODH interaction site; other site 941968011460 cubane metal cluster (B-cluster) [ion binding]; other site 941968011461 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 941968011465 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 941968011466 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 941968011467 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 941968011470 1 probable transmembrane helix predicted for cbot02240 by TMHMM2.0 at aa 21-43 941968011471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968011472 1 probable transmembrane helix predicted for cbot02241 by TMHMM2.0 at aa 20-42 941968011475 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 941968011478 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 941968011479 P loop nucleotide binding; other site 941968011480 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 941968011481 switch II; other site 941968011484 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 941968011485 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968011488 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 941968011490 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 941968011491 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941968011492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941968011493 ligand binding site [chemical binding]; other site 941968011495 1 probable transmembrane helix predicted for cbot02247 by TMHMM2.0 at aa 15-37 941968011498 flagellar motor protein MotA; Validated; Region: PRK08124 941968011499 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 941968011504 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968011505 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968011506 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 941968011512 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 941968011516 potential frameshift: common BLAST hit: gi|226949502|ref|YP_002804593.1| oligopeptide transporter, OPT family 941968011517 OPT oligopeptide transporter protein; Region: OPT; cl14607 941968011520 OPT oligopeptide transporter protein; Region: OPT; cl14607 941968011523 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 941968011524 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 941968011525 metal binding site [ion binding]; metal-binding site 941968011526 dimer interface [polypeptide binding]; other site 941968011530 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 941968011531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968011532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968011533 catalytic residue [active] 941968011535 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 941968011539 1 probable transmembrane helix predicted for cbot02257 by TMHMM2.0 at aa 2-24 941968011541 oxidoreductase; Provisional; Region: PRK08017 941968011542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968011543 NAD(P) binding site [chemical binding]; other site 941968011544 active site 941968011546 1 probable transmembrane helix predicted for cbot02259 by TMHMM2.0 at aa 25-47 941968011547 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 941968011548 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941968011549 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 941968011550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968011551 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941968011552 Walker A/P-loop; other site 941968011553 ATP binding site [chemical binding]; other site 941968011554 Q-loop/lid; other site 941968011555 ABC transporter signature motif; other site 941968011556 Walker B; other site 941968011557 D-loop; other site 941968011558 H-loop/switch region; other site 941968011563 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 941968011564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968011565 Coenzyme A binding pocket [chemical binding]; other site 941968011567 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968011568 MarR family; Region: MarR_2; pfam12802 941968011571 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 941968011573 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 941968011574 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 941968011577 Predicted dehydrogenase [General function prediction only]; Region: COG0579 941968011578 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941968011579 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 941968011586 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 941968011587 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968011588 DNA binding residues [nucleotide binding] 941968011589 drug binding residues [chemical binding]; other site 941968011590 dimer interface [polypeptide binding]; other site 941968011591 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 941968011594 1 probable transmembrane helix predicted for cbot02268 by TMHMM2.0 at aa 12-34 941968011596 Amino acid permease; Region: AA_permease_2; pfam13520 941968011599 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 941968011600 putative ADP-ribose binding site [chemical binding]; other site 941968011601 putative active site [active] 941968011604 1 probable transmembrane helix predicted for cbot02270 by TMHMM2.0 at aa 35-57 941968011606 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 941968011608 MarR family; Region: MarR_2; cl17246 941968011609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968011612 TIGR03987 family protein; Region: TIGR03987 941968011614 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 941968011615 substrate binding site [chemical binding]; other site 941968011616 multimerization interface [polypeptide binding]; other site 941968011617 ATP binding site [chemical binding]; other site 941968011618 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 941968011621 potential protein location (hypothetical protein) that overlaps protein (substrate-specific component ThiW of predicted thiazole ECF transporter) 941968011623 1 probable transmembrane helix predicted for cbot02279 by TMHMM2.0 at aa 25-44 941968011624 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968011627 1 probable transmembrane helix predicted for cbot02280 by TMHMM2.0 at aa 2-21 941968011630 Mor transcription activator family; Region: Mor; cl02360 941968011633 AAA domain; Region: AAA_26; pfam13500 941968011634 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 941968011636 biotin synthase; Region: bioB; TIGR00433 941968011637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968011638 FeS/SAM binding site; other site 941968011639 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 941968011645 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 941968011649 hypothetical protein; Provisional; Region: PRK09272 941968011653 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 941968011656 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941968011657 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941968011658 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941968011659 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 941968011660 active site 941968011664 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 941968011665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968011668 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 941968011670 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 941968011671 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 941968011672 active site 941968011674 1 probable transmembrane helix predicted for cbot02291 by TMHMM2.0 at aa 21-43 941968011675 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968011676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968011678 YmaF family; Region: YmaF; pfam12788 941968011679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968011680 non-specific DNA binding site [nucleotide binding]; other site 941968011681 salt bridge; other site 941968011682 sequence-specific DNA binding site [nucleotide binding]; other site 941968011688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968011689 non-specific DNA binding site [nucleotide binding]; other site 941968011690 salt bridge; other site 941968011691 sequence-specific DNA binding site [nucleotide binding]; other site 941968011694 Bacterial Ig-like domain; Region: Big_5; pfam13205 941968011697 potential frameshift: common BLAST hit: gi|188587690|ref|YP_001921480.1| DNA-methyltransferase 941968011698 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 941968011700 1 probable transmembrane helix predicted for cbot02307 by TMHMM2.0 at aa 33-52 941968011702 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 941968011703 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 941968011704 active site 941968011705 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941968011711 Haemolysin XhlA; Region: XhlA; pfam10779 941968011714 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 941968011715 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941968011716 DNA binding residues [nucleotide binding] 941968011720 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 941968011721 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 941968011722 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 941968011724 1 probable transmembrane helix predicted for cbot02316 by TMHMM2.0 at aa 20-42 941968011725 Baseplate J-like protein; Region: Baseplate_J; pfam04865 941968011727 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 941968011729 1 probable transmembrane helix predicted for cbot02318 by TMHMM2.0 at aa 12-31 941968011732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 941968011734 1 probable transmembrane helix predicted for cbot02321 by TMHMM2.0 at aa 37-59 941968011736 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 941968011744 Phage XkdN-like protein; Region: XkdN; pfam08890 941968011746 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 941968011748 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 941968011751 1 probable transmembrane helix predicted for cbot02328 by TMHMM2.0 at aa 21-43 941968011752 1 probable transmembrane helix predicted for cbot02331 by TMHMM2.0 at aa 44-66 941968011754 1 probable transmembrane helix predicted for cbot02332 by TMHMM2.0 at aa 4-22 941968011755 1 probable transmembrane helix predicted for cbot02333 by TMHMM2.0 at aa 20-42 941968011757 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 941968011760 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 941968011763 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 941968011765 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 941968011768 Phage terminase large subunit; Region: Terminase_3; cl12054 941968011769 Terminase-like family; Region: Terminase_6; pfam03237 941968011773 Phage terminase small subunit; Region: Phage_terminase; pfam10668 941968011774 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 941968011780 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 941968011781 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 941968011786 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 941968011787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968011788 active site 941968011789 DNA binding site [nucleotide binding] 941968011790 Int/Topo IB signature motif; other site 941968011794 1 probable transmembrane helix predicted for cbot02352 by TMHMM2.0 at aa 30-52 941968011796 1 probable transmembrane helix predicted for cbot02353 by TMHMM2.0 at aa 15-37 941968011797 1 probable transmembrane helix predicted for cbot02354 by TMHMM2.0 at aa 12-34 941968011798 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 941968011799 1 probable transmembrane helix predicted for cbot02356 by TMHMM2.0 at aa 25-47 941968011800 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 941968011803 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 941968011804 metal binding site [ion binding]; metal-binding site 941968011806 1 probable transmembrane helix predicted for cbot02361 by TMHMM2.0 at aa 26-48 941968011808 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 941968011810 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968011811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968011812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968011813 DNA binding residues [nucleotide binding] 941968011818 hypothetical protein; Validated; Region: PRK08116 941968011819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968011820 Walker A motif; other site 941968011821 ATP binding site [chemical binding]; other site 941968011822 Walker B motif; other site 941968011823 arginine finger; other site 941968011826 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 941968011829 1 probable transmembrane helix predicted for cbot02369 by TMHMM2.0 at aa 29-51 941968011830 RecT family; Region: RecT; cl04285 941968011832 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 941968011838 Prophage antirepressor [Transcription]; Region: COG3617 941968011839 BRO family, N-terminal domain; Region: Bro-N; smart01040 941968011840 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 941968011843 1 probable transmembrane helix predicted for cbot02377 by TMHMM2.0 at aa 31-53 941968011845 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968011846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968011847 non-specific DNA binding site [nucleotide binding]; other site 941968011848 salt bridge; other site 941968011849 sequence-specific DNA binding site [nucleotide binding]; other site 941968011852 1 probable transmembrane helix predicted for cbot02378 by TMHMM2.0 at aa 19-41 941968011853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968011854 non-specific DNA binding site [nucleotide binding]; other site 941968011855 salt bridge; other site 941968011856 sequence-specific DNA binding site [nucleotide binding]; other site 941968011860 Domain of unknown function (DUF955); Region: DUF955; cl01076 941968011862 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 941968011863 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 941968011867 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 941968011868 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 941968011869 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 941968011870 catalytic residues [active] 941968011871 catalytic nucleophile [active] 941968011872 Recombinase; Region: Recombinase; pfam07508 941968011873 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 941968011877 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 941968011878 hypothetical protein; Provisional; Region: PRK05802 941968011879 FAD binding pocket [chemical binding]; other site 941968011880 FAD binding motif [chemical binding]; other site 941968011881 phosphate binding motif [ion binding]; other site 941968011882 beta-alpha-beta structure motif; other site 941968011883 NAD binding pocket [chemical binding]; other site 941968011884 Iron coordination center [ion binding]; other site 941968011886 1 probable transmembrane helix predicted for cbot02386 by TMHMM2.0 at aa 20-42 941968011889 methionine sulfoxide reductase B; Provisional; Region: PRK00222 941968011890 SelR domain; Region: SelR; pfam01641 941968011892 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 941968011893 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 941968011894 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941968011898 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968011899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968011900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968011901 Walker A/P-loop; other site 941968011902 ATP binding site [chemical binding]; other site 941968011903 Q-loop/lid; other site 941968011904 ABC transporter signature motif; other site 941968011905 Walker B; other site 941968011906 D-loop; other site 941968011907 H-loop/switch region; other site 941968011913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968011914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968011915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968011916 Walker A/P-loop; other site 941968011917 ATP binding site [chemical binding]; other site 941968011918 Q-loop/lid; other site 941968011919 ABC transporter signature motif; other site 941968011920 Walker B; other site 941968011921 D-loop; other site 941968011922 H-loop/switch region; other site 941968011929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968011930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968011935 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968011936 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968011937 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968011938 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 941968011939 Walker A/P-loop; other site 941968011940 ATP binding site [chemical binding]; other site 941968011941 Q-loop/lid; other site 941968011942 ABC transporter signature motif; other site 941968011943 Walker B; other site 941968011944 D-loop; other site 941968011945 H-loop/switch region; other site 941968011950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968011951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968011952 dimer interface [polypeptide binding]; other site 941968011953 phosphorylation site [posttranslational modification] 941968011954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968011955 ATP binding site [chemical binding]; other site 941968011956 Mg2+ binding site [ion binding]; other site 941968011957 G-X-G motif; other site 941968011963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968011964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968011965 active site 941968011966 phosphorylation site [posttranslational modification] 941968011967 intermolecular recognition site; other site 941968011968 dimerization interface [polypeptide binding]; other site 941968011969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968011970 DNA binding site [nucleotide binding] 941968011974 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 941968011975 active site 941968011976 catalytic site [active] 941968011977 substrate binding site [chemical binding]; other site 941968011980 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 941968011982 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 941968011984 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941968011985 active site 941968011986 catalytic residues [active] 941968011987 metal binding site [ion binding]; metal-binding site 941968011989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968011990 non-specific DNA binding site [nucleotide binding]; other site 941968011991 salt bridge; other site 941968011992 sequence-specific DNA binding site [nucleotide binding]; other site 941968011995 transglutaminase; Provisional; Region: tgl; PRK03187 941968011996 short chain dehydrogenase; Provisional; Region: PRK06701 941968011997 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 941968011998 NAD binding site [chemical binding]; other site 941968011999 metal binding site [ion binding]; metal-binding site 941968012000 active site 941968012003 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 941968012005 1 probable transmembrane helix predicted for cbot02409 by TMHMM2.0 at aa 20-42 941968012008 1 probable transmembrane helix predicted for cbot02412 by TMHMM2.0 at aa 85-107 941968012010 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 941968012011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968012013 Spore germination protein; Region: Spore_permease; pfam03845 941968012016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941968012017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968012020 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 941968012021 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 941968012022 active site 941968012023 NTP binding site [chemical binding]; other site 941968012024 metal binding triad [ion binding]; metal-binding site 941968012025 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 941968012026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968012027 Zn2+ binding site [ion binding]; other site 941968012028 Mg2+ binding site [ion binding]; other site 941968012029 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 941968012032 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 941968012034 1 probable transmembrane helix predicted for cbot02420 by TMHMM2.0 at aa 10-32 941968012035 Predicted transcriptional regulators [Transcription]; Region: COG1695 941968012036 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 941968012039 1 probable transmembrane helix predicted for cbot02423 by TMHMM2.0 at aa 15-37 941968012040 Fic/DOC family; Region: Fic; cl00960 941968012041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968012042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968012043 dimer interface [polypeptide binding]; other site 941968012044 phosphorylation site [posttranslational modification] 941968012045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968012046 ATP binding site [chemical binding]; other site 941968012047 Mg2+ binding site [ion binding]; other site 941968012048 G-X-G motif; other site 941968012054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968012055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968012056 active site 941968012057 phosphorylation site [posttranslational modification] 941968012058 intermolecular recognition site; other site 941968012059 dimerization interface [polypeptide binding]; other site 941968012060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968012061 DNA binding site [nucleotide binding] 941968012066 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 941968012068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968012069 Walker A motif; other site 941968012070 ATP binding site [chemical binding]; other site 941968012071 Walker B motif; other site 941968012075 Glucose inhibited division protein A; Region: GIDA; pfam01134 941968012076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941968012077 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 941968012082 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 941968012083 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 941968012084 tetramer interface [polypeptide binding]; other site 941968012085 active site 941968012090 Uncharacterized conserved protein [Function unknown]; Region: COG2155 941968012092 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941968012093 dimerization domain swap beta strand [polypeptide binding]; other site 941968012094 regulatory protein interface [polypeptide binding]; other site 941968012095 active site 941968012096 regulatory phosphorylation site [posttranslational modification]; other site 941968012098 aspartate aminotransferase; Provisional; Region: PRK05764 941968012099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968012100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968012101 homodimer interface [polypeptide binding]; other site 941968012102 catalytic residue [active] 941968012105 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 941968012108 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 941968012112 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 941968012114 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 941968012115 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 941968012116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968012117 Zn2+ binding site [ion binding]; other site 941968012118 Mg2+ binding site [ion binding]; other site 941968012127 recombinase A; Provisional; Region: recA; PRK09354 941968012128 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 941968012129 hexamer interface [polypeptide binding]; other site 941968012130 Walker A motif; other site 941968012131 ATP binding site [chemical binding]; other site 941968012132 Walker B motif; other site 941968012136 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 941968012141 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 941968012142 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941968012148 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 941968012149 Tetraspanin family; Region: Tetraspannin; pfam00335 941968012150 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 941968012151 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941968012152 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941968012159 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 941968012160 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 941968012161 active site 941968012165 aspartate kinase I; Reviewed; Region: PRK08210 941968012166 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 941968012167 nucleotide binding site [chemical binding]; other site 941968012168 substrate binding site [chemical binding]; other site 941968012169 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 941968012170 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 941968012173 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 941968012176 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941968012177 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941968012178 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941968012182 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 941968012183 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 941968012184 RNase E interface [polypeptide binding]; other site 941968012185 trimer interface [polypeptide binding]; other site 941968012186 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 941968012187 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 941968012188 RNase E interface [polypeptide binding]; other site 941968012189 trimer interface [polypeptide binding]; other site 941968012190 active site 941968012191 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 941968012192 putative nucleic acid binding region [nucleotide binding]; other site 941968012193 G-X-X-G motif; other site 941968012194 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 941968012195 RNA binding site [nucleotide binding]; other site 941968012196 domain interface; other site 941968012211 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 941968012212 16S/18S rRNA binding site [nucleotide binding]; other site 941968012213 S13e-L30e interaction site [polypeptide binding]; other site 941968012214 25S rRNA binding site [nucleotide binding]; other site 941968012216 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 941968012217 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 941968012218 active site 941968012219 Riboflavin kinase; Region: Flavokinase; pfam01687 941968012223 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 941968012224 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 941968012225 RNA binding site [nucleotide binding]; other site 941968012226 active site 941968012228 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 941968012229 DHH family; Region: DHH; pfam01368 941968012230 DHHA1 domain; Region: DHHA1; pfam02272 941968012234 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 941968012237 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 941968012238 translation initiation factor IF-2; Region: IF-2; TIGR00487 941968012239 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 941968012240 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 941968012241 G1 box; other site 941968012242 putative GEF interaction site [polypeptide binding]; other site 941968012243 GTP/Mg2+ binding site [chemical binding]; other site 941968012244 Switch I region; other site 941968012245 G2 box; other site 941968012246 G3 box; other site 941968012247 Switch II region; other site 941968012248 G4 box; other site 941968012249 G5 box; other site 941968012250 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 941968012251 Translation-initiation factor 2; Region: IF-2; pfam11987 941968012252 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 941968012263 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 941968012264 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 941968012265 putative RNA binding cleft [nucleotide binding]; other site 941968012267 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 941968012268 NusA N-terminal domain; Region: NusA_N; pfam08529 941968012269 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 941968012270 RNA binding site [nucleotide binding]; other site 941968012271 homodimer interface [polypeptide binding]; other site 941968012272 NusA-like KH domain; Region: KH_5; pfam13184 941968012273 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941968012274 G-X-X-G motif; other site 941968012284 Sm and related proteins; Region: Sm_like; cl00259 941968012285 ribosome maturation protein RimP; Reviewed; Region: PRK00092 941968012286 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 941968012287 putative oligomer interface [polypeptide binding]; other site 941968012288 putative RNA binding site [nucleotide binding]; other site 941968012291 DNA polymerase III PolC; Validated; Region: polC; PRK00448 941968012292 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 941968012293 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 941968012294 generic binding surface II; other site 941968012295 generic binding surface I; other site 941968012296 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941968012297 active site 941968012298 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941968012299 active site 941968012300 catalytic site [active] 941968012301 substrate binding site [chemical binding]; other site 941968012302 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 941968012313 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 941968012314 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941968012315 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941968012319 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 941968012320 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941968012321 active site 941968012322 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941968012323 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941968012324 putative substrate binding region [chemical binding]; other site 941968012328 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 941968012329 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 941968012330 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 941968012331 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 941968012336 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 941968012339 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 941968012340 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 941968012342 1 probable transmembrane helix predicted for cbot02468 by TMHMM2.0 at aa 17-39 941968012343 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 941968012344 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 941968012345 catalytic residue [active] 941968012346 putative FPP diphosphate binding site; other site 941968012347 putative FPP binding hydrophobic cleft; other site 941968012348 dimer interface [polypeptide binding]; other site 941968012349 putative IPP diphosphate binding site; other site 941968012351 ribosome recycling factor; Reviewed; Region: frr; PRK00083 941968012352 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 941968012353 hinge region; other site 941968012356 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 941968012357 putative nucleotide binding site [chemical binding]; other site 941968012358 uridine monophosphate binding site [chemical binding]; other site 941968012359 homohexameric interface [polypeptide binding]; other site 941968012363 elongation factor Ts; Provisional; Region: tsf; PRK09377 941968012364 UBA/TS-N domain; Region: UBA; pfam00627 941968012365 Elongation factor TS; Region: EF_TS; pfam00889 941968012366 Elongation factor TS; Region: EF_TS; pfam00889 941968012368 1 probable transmembrane helix predicted for cbot02472 by TMHMM2.0 at aa 23-45 941968012372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 941968012373 rRNA interaction site [nucleotide binding]; other site 941968012374 S8 interaction site; other site 941968012375 putative laminin-1 binding site; other site 941968012378 transcriptional repressor CodY; Validated; Region: PRK04158 941968012379 CodY GAF-like domain; Region: CodY; pfam06018 941968012380 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 941968012384 DNA topoisomerase I; Validated; Region: PRK05582 941968012385 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 941968012386 active site 941968012387 interdomain interaction site; other site 941968012388 putative metal-binding site [ion binding]; other site 941968012389 nucleotide binding site [chemical binding]; other site 941968012390 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941968012391 domain I; other site 941968012392 DNA binding groove [nucleotide binding] 941968012393 phosphate binding site [ion binding]; other site 941968012394 domain II; other site 941968012395 domain III; other site 941968012396 nucleotide binding site [chemical binding]; other site 941968012397 catalytic site [active] 941968012398 domain IV; other site 941968012399 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941968012400 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941968012401 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941968012412 DNA protecting protein DprA; Region: dprA; TIGR00732 941968012413 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 941968012415 1 probable transmembrane helix predicted for cbot02476 by TMHMM2.0 at aa 20-42 941968012417 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 941968012418 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941968012419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968012420 Walker A motif; other site 941968012421 ATP binding site [chemical binding]; other site 941968012422 Walker B motif; other site 941968012423 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 941968012426 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 941968012427 RNA/DNA hybrid binding site [nucleotide binding]; other site 941968012428 active site 941968012431 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 941968012432 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 941968012433 GTP/Mg2+ binding site [chemical binding]; other site 941968012434 G4 box; other site 941968012435 G5 box; other site 941968012436 G1 box; other site 941968012437 Switch I region; other site 941968012438 G2 box; other site 941968012439 G3 box; other site 941968012440 Switch II region; other site 941968012443 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 941968012444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941968012445 Catalytic site [active] 941968012448 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 941968012450 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 941968012452 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 941968012453 RimM N-terminal domain; Region: RimM; pfam01782 941968012454 PRC-barrel domain; Region: PRC; pfam05239 941968012457 1 probable transmembrane helix predicted for cbot02483 by TMHMM2.0 at aa 7-29 941968012459 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 941968012460 hypothetical protein; Provisional; Region: PRK00468 941968012462 1 probable transmembrane helix predicted for cbot02484 by TMHMM2.0 at aa 7-29 941968012464 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 941968012467 signal recognition particle protein; Provisional; Region: PRK10867 941968012468 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 941968012469 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941968012470 P loop; other site 941968012471 GTP binding site [chemical binding]; other site 941968012472 Signal peptide binding domain; Region: SRP_SPB; pfam02978 941968012478 putative DNA-binding protein; Validated; Region: PRK00118 941968012480 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 941968012481 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 941968012482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968012486 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941968012487 AAA domain; Region: AAA_23; pfam13476 941968012488 Walker A/P-loop; other site 941968012489 ATP binding site [chemical binding]; other site 941968012490 Q-loop/lid; other site 941968012491 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 941968012492 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 941968012493 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941968012494 Q-loop/lid; other site 941968012495 ABC transporter signature motif; other site 941968012496 Walker B; other site 941968012497 D-loop; other site 941968012498 H-loop/switch region; other site 941968012505 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 941968012506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968012507 FeS/SAM binding site; other site 941968012510 1 probable transmembrane helix predicted for cbot02491 by TMHMM2.0 at aa 12-34 941968012511 ribonuclease III; Reviewed; Region: rnc; PRK00102 941968012512 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 941968012513 dimerization interface [polypeptide binding]; other site 941968012514 active site 941968012515 metal binding site [ion binding]; metal-binding site 941968012516 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 941968012517 dsRNA binding site [nucleotide binding]; other site 941968012522 acyl carrier protein; Provisional; Region: acpP; PRK00982 941968012524 putative phosphate acyltransferase; Provisional; Region: PRK05331 941968012530 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 941968012533 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 941968012535 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 941968012536 propionate/acetate kinase; Provisional; Region: PRK12379 941968012540 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 941968012542 1 probable transmembrane helix predicted for cbot02498 by TMHMM2.0 at aa 7-29 941968012544 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941968012548 potential frameshift: common BLAST hit: gi|226949816|ref|YP_002804907.1| D-proline reductase subunit gamma PrdB 941968012550 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 941968012552 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 941968012555 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 941968012556 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 941968012560 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941968012564 Cache domain; Region: Cache_1; pfam02743 941968012565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968012566 dimerization interface [polypeptide binding]; other site 941968012567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968012568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968012569 dimer interface [polypeptide binding]; other site 941968012570 putative CheW interface [polypeptide binding]; other site 941968012577 Transcriptional regulator; Region: Rrf2; cl17282 941968012579 Uncharacterized conserved protein [Function unknown]; Region: COG1915 941968012580 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 941968012581 Uncharacterized conserved protein [Function unknown]; Region: COG1915 941968012582 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 941968012584 1 probable transmembrane helix predicted for cbot02511 by TMHMM2.0 at aa 10-32 941968012586 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941968012590 proline racemase; Provisional; Region: PRK13969 941968012591 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 941968012594 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 941968012597 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 941968012599 potential frameshift: common BLAST hit: gi|170755994|ref|YP_001782020.1| D-proline reductase subunit PrdB 941968012601 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 941968012603 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 941968012607 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 941968012608 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 941968012613 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 941968012614 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 941968012615 SLBB domain; Region: SLBB; pfam10531 941968012620 Predicted permease; Region: DUF318; cl17795 941968012624 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 941968012628 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941968012629 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 941968012630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968012631 putative active site [active] 941968012632 heme pocket [chemical binding]; other site 941968012633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968012634 Walker A motif; other site 941968012635 ATP binding site [chemical binding]; other site 941968012636 Walker B motif; other site 941968012637 arginine finger; other site 941968012638 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968012650 hypothetical protein; Provisional; Region: PRK13670 941968012651 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 941968012653 1 probable transmembrane helix predicted for cbot02529 by TMHMM2.0 at aa 34-56 941968012654 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 941968012655 Nucleoside recognition; Region: Gate; pfam07670 941968012656 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 941968012657 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 941968012658 active site 941968012659 (T/H)XGH motif; other site 941968012661 1 probable transmembrane helix predicted for cbot02532 by TMHMM2.0 at aa 4-26 941968012662 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 941968012663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968012664 S-adenosylmethionine binding site [chemical binding]; other site 941968012667 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 941968012668 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 941968012669 ssDNA binding site; other site 941968012670 generic binding surface II; other site 941968012671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968012672 ATP binding site [chemical binding]; other site 941968012673 putative Mg++ binding site [ion binding]; other site 941968012674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968012675 nucleotide binding region [chemical binding]; other site 941968012676 ATP-binding site [chemical binding]; other site 941968012683 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 941968012684 DAK2 domain; Region: Dak2; pfam02734 941968012691 Asp23 family; Region: Asp23; pfam03780 941968012694 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 941968012696 Thiamine pyrophosphokinase; Region: TPK; cd07995 941968012697 active site 941968012698 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 941968012699 dimerization interface [polypeptide binding]; other site 941968012700 thiamine binding site [chemical binding]; other site 941968012703 1 probable transmembrane helix predicted for cbot02540 by TMHMM2.0 at aa 22-44 941968012704 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 941968012705 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 941968012706 substrate binding site [chemical binding]; other site 941968012707 hexamer interface [polypeptide binding]; other site 941968012708 metal binding site [ion binding]; metal-binding site 941968012710 1 probable transmembrane helix predicted for cbot02541 by TMHMM2.0 at aa 20-42 941968012712 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 941968012713 GTPase RsgA; Reviewed; Region: PRK00098 941968012714 RNA binding site [nucleotide binding]; other site 941968012715 homodimer interface [polypeptide binding]; other site 941968012716 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 941968012717 GTPase/Zn-binding domain interface [polypeptide binding]; other site 941968012718 GTP/Mg2+ binding site [chemical binding]; other site 941968012719 G4 box; other site 941968012720 G5 box; other site 941968012721 G1 box; other site 941968012722 Switch I region; other site 941968012723 G2 box; other site 941968012724 G3 box; other site 941968012725 Switch II region; other site 941968012727 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 941968012728 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941968012729 active site 941968012730 ATP binding site [chemical binding]; other site 941968012731 substrate binding site [chemical binding]; other site 941968012732 activation loop (A-loop); other site 941968012733 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941968012734 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941968012735 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941968012749 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 941968012750 active site 941968012755 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941968012756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968012757 FeS/SAM binding site; other site 941968012759 1 probable transmembrane helix predicted for cbot02545 by TMHMM2.0 at aa 20-42 941968012760 16S rRNA methyltransferase B; Provisional; Region: PRK14902 941968012761 NusB family; Region: NusB; pfam01029 941968012762 putative RNA binding site [nucleotide binding]; other site 941968012763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968012764 S-adenosylmethionine binding site [chemical binding]; other site 941968012765 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 941968012770 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 941968012771 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 941968012772 putative active site [active] 941968012773 substrate binding site [chemical binding]; other site 941968012774 putative cosubstrate binding site; other site 941968012775 catalytic site [active] 941968012776 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 941968012777 substrate binding site [chemical binding]; other site 941968012781 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941968012782 active site 941968012783 catalytic residues [active] 941968012784 metal binding site [ion binding]; metal-binding site 941968012786 1 probable transmembrane helix predicted for cbot02548 by TMHMM2.0 at aa 26-48 941968012789 primosome assembly protein PriA; Validated; Region: PRK05580 941968012790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968012791 ATP binding site [chemical binding]; other site 941968012792 putative Mg++ binding site [ion binding]; other site 941968012793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968012794 nucleotide binding region [chemical binding]; other site 941968012795 ATP-binding site [chemical binding]; other site 941968012801 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 941968012802 Flavoprotein; Region: Flavoprotein; pfam02441 941968012803 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 941968012805 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 941968012807 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 941968012808 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 941968012809 catalytic site [active] 941968012810 G-X2-G-X-G-K; other site 941968012813 hypothetical protein; Provisional; Region: PRK04323 941968012815 hypothetical protein; Provisional; Region: PRK11820 941968012816 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 941968012817 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 941968012821 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 941968012822 active site 941968012823 homotetramer interface [polypeptide binding]; other site 941968012824 homodimer interface [polypeptide binding]; other site 941968012826 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 941968012827 sequence-specific DNA binding site [nucleotide binding]; other site 941968012828 salt bridge; other site 941968012830 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 941968012831 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 941968012837 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 941968012838 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941968012839 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 941968012845 GTP-binding protein Der; Reviewed; Region: PRK00093 941968012846 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 941968012847 G1 box; other site 941968012848 GTP/Mg2+ binding site [chemical binding]; other site 941968012849 Switch I region; other site 941968012850 G2 box; other site 941968012851 Switch II region; other site 941968012852 G3 box; other site 941968012853 G4 box; other site 941968012854 G5 box; other site 941968012855 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 941968012856 G1 box; other site 941968012857 GTP/Mg2+ binding site [chemical binding]; other site 941968012858 Switch I region; other site 941968012859 G2 box; other site 941968012860 G3 box; other site 941968012861 Switch II region; other site 941968012862 G4 box; other site 941968012863 G5 box; other site 941968012870 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 941968012871 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 941968012872 Protein of unknown function (DUF512); Region: DUF512; pfam04459 941968012874 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 941968012875 PhoU domain; Region: PhoU; pfam01895 941968012876 PhoU domain; Region: PhoU; pfam01895 941968012879 1 probable transmembrane helix predicted for cbot02563 by TMHMM2.0 at aa 63-85 941968012880 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 941968012881 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941968012882 Walker A/P-loop; other site 941968012883 ATP binding site [chemical binding]; other site 941968012884 Q-loop/lid; other site 941968012885 ABC transporter signature motif; other site 941968012886 Walker B; other site 941968012887 D-loop; other site 941968012888 H-loop/switch region; other site 941968012893 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 941968012894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968012895 dimer interface [polypeptide binding]; other site 941968012896 conserved gate region; other site 941968012897 putative PBP binding loops; other site 941968012898 ABC-ATPase subunit interface; other site 941968012902 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 941968012903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968012904 dimer interface [polypeptide binding]; other site 941968012905 conserved gate region; other site 941968012906 putative PBP binding loops; other site 941968012907 ABC-ATPase subunit interface; other site 941968012909 PBP superfamily domain; Region: PBP_like_2; cl17296 941968012912 1 probable transmembrane helix predicted for cbot02567 by TMHMM2.0 at aa 20-39 941968012914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968012915 dimerization interface [polypeptide binding]; other site 941968012916 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941968012917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968012918 putative active site [active] 941968012919 heme pocket [chemical binding]; other site 941968012920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968012921 dimer interface [polypeptide binding]; other site 941968012922 phosphorylation site [posttranslational modification] 941968012923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968012924 ATP binding site [chemical binding]; other site 941968012925 Mg2+ binding site [ion binding]; other site 941968012926 G-X-G motif; other site 941968012934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968012935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968012936 active site 941968012937 phosphorylation site [posttranslational modification] 941968012938 intermolecular recognition site; other site 941968012939 dimerization interface [polypeptide binding]; other site 941968012940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968012941 DNA binding site [nucleotide binding] 941968012942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968012943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968012944 DNA binding site [nucleotide binding] 941968012946 1 probable transmembrane helix predicted for cbot02569 by TMHMM2.0 at aa 6-28 941968012949 1 probable transmembrane helix predicted for cbot02570 by TMHMM2.0 at aa 15-34 941968012952 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 941968012953 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 941968012956 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 941968012957 ATP cone domain; Region: ATP-cone; pfam03477 941968012959 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 941968012961 sporulation sigma factor SigG; Reviewed; Region: PRK08215 941968012962 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968012963 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941968012964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968012965 DNA binding residues [nucleotide binding] 941968012970 sporulation sigma factor SigE; Reviewed; Region: PRK08301 941968012971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968012972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968012973 DNA binding residues [nucleotide binding] 941968012976 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 941968012977 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 941968012979 cell division protein FtsZ; Validated; Region: PRK09330 941968012980 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 941968012981 nucleotide binding site [chemical binding]; other site 941968012982 SulA interaction site; other site 941968012989 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 941968012990 Cell division protein FtsA; Region: FtsA; smart00842 941968012991 Cell division protein FtsA; Region: FtsA; pfam14450 941968012995 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941968012996 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 941968012997 DXD motif; other site 941968013000 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 941968013001 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 941968013002 Walker A motif; other site 941968013003 ATP binding site [chemical binding]; other site 941968013004 Walker B motif; other site 941968013007 potential frameshift: common BLAST hit: gi|237795979|ref|YP_002863531.1| shikimate 5-dehydrogenase 941968013008 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941968013009 shikimate binding site; other site 941968013010 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 941968013011 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941968013012 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941968013015 DNA binding residues [nucleotide binding] 941968013016 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 941968013018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968013019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968013020 non-specific DNA binding site [nucleotide binding]; other site 941968013021 salt bridge; other site 941968013022 sequence-specific DNA binding site [nucleotide binding]; other site 941968013025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968013026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968013027 non-specific DNA binding site [nucleotide binding]; other site 941968013028 salt bridge; other site 941968013029 sequence-specific DNA binding site [nucleotide binding]; other site 941968013034 Winged helix-turn helix; Region: HTH_29; pfam13551 941968013035 Helix-turn-helix domain; Region: HTH_28; pfam13518 941968013037 potential frameshift: common BLAST hit: gi|237794755|ref|YP_002862307.1| transposase 941968013038 HTH-like domain; Region: HTH_21; pfam13276 941968013039 Integrase core domain; Region: rve; pfam00665 941968013040 1 probable transmembrane helix predicted for cbot02590 by TMHMM2.0 at aa 5-27 941968013042 1 probable transmembrane helix predicted for cbot02591 by TMHMM2.0 at aa 39-61 941968013043 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968013044 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968013045 active site 941968013046 metal binding site [ion binding]; metal-binding site 941968013047 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968013053 Haemolysin XhlA; Region: XhlA; pfam10779 941968013054 1 probable transmembrane helix predicted for cbot02594 by TMHMM2.0 at aa 48-70 941968013055 1 probable transmembrane helix predicted for cbot02595 by TMHMM2.0 at aa 20-42 941968013056 1 probable transmembrane helix predicted for cbot02596 by TMHMM2.0 at aa 20-42 941968013057 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 941968013058 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 941968013061 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 941968013064 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 941968013067 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 941968013072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941968013075 Predicted membrane protein [Function unknown]; Region: COG1511 941968013079 Phage XkdN-like protein; Region: XkdN; pfam08890 941968013082 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 941968013084 1 probable transmembrane helix predicted for cbot02609 by TMHMM2.0 at aa 53-75 941968013085 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 941968013091 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 941968013093 1 probable transmembrane helix predicted for cbot02615 by TMHMM2.0 at aa 25-47 941968013095 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 941968013097 1 probable transmembrane helix predicted for cbot02617 by TMHMM2.0 at aa 15-37 941968013099 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 941968013100 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 941968013103 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 941968013104 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 941968013106 1 probable transmembrane helix predicted for cbot02622 by TMHMM2.0 at aa 28-50 941968013110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 941968013111 Terminase-like family; Region: Terminase_6; pfam03237 941968013112 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 941968013113 1 probable transmembrane helix predicted for cbot02623 by TMHMM2.0 at aa 17-39 941968013115 Terminase small subunit; Region: Terminase_2; pfam03592 941968013117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968013119 potential frameshift: common BLAST hit: gi|170756489|ref|YP_001781751.1| phage primase 941968013120 D5 N terminal like; Region: D5_N; smart00885 941968013121 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 941968013124 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 941968013125 nucleotide binding site [chemical binding]; other site 941968013128 1 probable transmembrane helix predicted for cbot02629 by TMHMM2.0 at aa 15-37 941968013130 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 941968013133 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 941968013134 1 probable transmembrane helix predicted for cbot02632 by TMHMM2.0 at aa 25-47 941968013135 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 941968013136 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 941968013137 active site 941968013138 metal-binding site 941968013140 Protein of unknown function (DUF669); Region: DUF669; pfam05037 941968013142 1 probable transmembrane helix predicted for cbot02635 by TMHMM2.0 at aa 5-27 941968013144 1 probable transmembrane helix predicted for cbot02636 by TMHMM2.0 at aa 15-34 941968013146 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941968013147 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 941968013148 AAA domain; Region: AAA_24; pfam13479 941968013149 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 941968013153 HepA-related protein (HARP); Region: HARP; pfam07443 941968013155 1 probable transmembrane helix predicted for cbot02639 by TMHMM2.0 at aa 29-51 941968013156 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 941968013158 VRR-NUC domain; Region: VRR_NUC; pfam08774 941968013161 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 941968013164 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941968013165 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 941968013166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968013167 nucleotide binding region [chemical binding]; other site 941968013168 ATP-binding site [chemical binding]; other site 941968013171 1 probable transmembrane helix predicted for cbot02645 by TMHMM2.0 at aa 10-32 941968013172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968013173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968013174 sequence-specific DNA binding site [nucleotide binding]; other site 941968013175 salt bridge; other site 941968013178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968013179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968013180 non-specific DNA binding site [nucleotide binding]; other site 941968013181 salt bridge; other site 941968013182 sequence-specific DNA binding site [nucleotide binding]; other site 941968013185 Domain of unknown function (DUF955); Region: DUF955; cl01076 941968013188 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 941968013189 catalytic residues [active] 941968013190 catalytic nucleophile [active] 941968013191 Recombinase; Region: Recombinase; pfam07508 941968013192 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 941968013196 sporulation sigma factor SigK; Reviewed; Region: PRK05803 941968013197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968013199 1 probable transmembrane helix predicted for cbot02651 by TMHMM2.0 at aa 13-32 941968013202 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 941968013205 conserved domain; Region: TIGR02271 941968013207 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 941968013208 1 probable transmembrane helix predicted for cbot02661 by TMHMM2.0 at aa 37-59 941968013210 RecT family; Region: RecT; pfam03837 941968013215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968013216 non-specific DNA binding site [nucleotide binding]; other site 941968013217 salt bridge; other site 941968013218 sequence-specific DNA binding site [nucleotide binding]; other site 941968013219 1 probable transmembrane helix predicted for cbot02663 by TMHMM2.0 at aa 7-29 941968013222 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941968013223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941968013226 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 941968013227 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 941968013228 Sugar specificity; other site 941968013229 Pyrimidine base specificity; other site 941968013230 ATP-binding site [chemical binding]; other site 941968013232 1 probable transmembrane helix predicted for cbot02665 by TMHMM2.0 at aa 25-47 941968013233 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941968013234 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 941968013235 Peptidase family U32; Region: Peptidase_U32; pfam01136 941968013239 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 941968013240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968013241 S-adenosylmethionine binding site [chemical binding]; other site 941968013243 YceG-like family; Region: YceG; pfam02618 941968013244 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 941968013245 dimerization interface [polypeptide binding]; other site 941968013248 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 941968013249 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 941968013250 G1 box; other site 941968013251 putative GEF interaction site [polypeptide binding]; other site 941968013252 GTP/Mg2+ binding site [chemical binding]; other site 941968013253 Switch I region; other site 941968013254 G2 box; other site 941968013255 G3 box; other site 941968013256 Switch II region; other site 941968013257 G4 box; other site 941968013258 G5 box; other site 941968013259 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 941968013260 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 941968013267 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 941968013268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968013269 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941968013275 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941968013276 metal binding site 2 [ion binding]; metal-binding site 941968013277 putative DNA binding helix; other site 941968013278 metal binding site 1 [ion binding]; metal-binding site 941968013279 dimer interface [polypeptide binding]; other site 941968013280 structural Zn2+ binding site [ion binding]; other site 941968013283 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 941968013286 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 941968013289 hypothetical protein; Provisional; Region: PRK05473 941968013291 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 941968013292 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 941968013293 motif 1; other site 941968013294 active site 941968013295 motif 2; other site 941968013296 motif 3; other site 941968013297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941968013305 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941968013307 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 941968013308 PRC-barrel domain; Region: PRC; pfam05239 941968013311 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 941968013312 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 941968013313 trimerization site [polypeptide binding]; other site 941968013314 active site 941968013316 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 941968013317 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941968013318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968013319 catalytic residue [active] 941968013321 Transcriptional regulator; Region: Rrf2; cl17282 941968013322 Rrf2 family protein; Region: rrf2_super; TIGR00738 941968013325 recombination factor protein RarA; Reviewed; Region: PRK13342 941968013326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968013327 Walker A motif; other site 941968013328 ATP binding site [chemical binding]; other site 941968013329 Walker B motif; other site 941968013330 arginine finger; other site 941968013331 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 941968013336 histidinol-phosphatase; Provisional; Region: PRK05588 941968013337 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941968013338 active site 941968013340 1 probable transmembrane helix predicted for cbot02683 by TMHMM2.0 at aa 5-27 941968013341 Predicted permeases [General function prediction only]; Region: COG0679 941968013344 EDD domain protein, DegV family; Region: DegV; TIGR00762 941968013345 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941968013347 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 941968013348 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 941968013349 CPxP motif; other site 941968013350 DsrE/DsrF-like family; Region: DrsE; pfam02635 941968013354 ornithine cyclodeaminase; Validated; Region: PRK08618 941968013355 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 941968013357 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968013358 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968013362 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968013363 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968013364 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968013365 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968013372 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 941968013373 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 941968013374 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 941968013378 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 941968013379 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 941968013380 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 941968013381 dimerization interface [polypeptide binding]; other site 941968013382 ATP binding site [chemical binding]; other site 941968013383 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 941968013384 dimerization interface [polypeptide binding]; other site 941968013385 ATP binding site [chemical binding]; other site 941968013386 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 941968013387 putative active site [active] 941968013388 catalytic triad [active] 941968013395 ornithine carbamoyltransferase; Provisional; Region: PRK04284 941968013396 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941968013397 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941968013402 carbamate kinase; Reviewed; Region: PRK12686 941968013403 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 941968013404 putative substrate binding site [chemical binding]; other site 941968013405 nucleotide binding site [chemical binding]; other site 941968013406 nucleotide binding site [chemical binding]; other site 941968013407 homodimer interface [polypeptide binding]; other site 941968013410 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941968013411 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941968013412 dimer interface [polypeptide binding]; other site 941968013413 active site 941968013414 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941968013415 folate binding site [chemical binding]; other site 941968013417 Uncharacterized conserved protein [Function unknown]; Region: COG2966 941968013418 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 941968013420 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 941968013422 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 941968013423 putative homodimer interface [polypeptide binding]; other site 941968013424 putative homotetramer interface [polypeptide binding]; other site 941968013425 putative allosteric switch controlling residues; other site 941968013426 putative metal binding site [ion binding]; other site 941968013427 putative homodimer-homodimer interface [polypeptide binding]; other site 941968013430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968013431 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941968013432 active site 941968013433 motif I; other site 941968013434 motif II; other site 941968013435 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941968013438 1 probable transmembrane helix predicted for cbot02701 by TMHMM2.0 at aa 7-29 941968013439 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 941968013440 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941968013441 active site 941968013442 nucleotide binding site [chemical binding]; other site 941968013443 HIGH motif; other site 941968013444 KMSKS motif; other site 941968013445 1 probable transmembrane helix predicted for cbot02702 by TMHMM2.0 at aa 20-42 941968013446 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 941968013447 NAD(P) binding site [chemical binding]; other site 941968013448 LDH/MDH dimer interface [polypeptide binding]; other site 941968013449 substrate binding site [chemical binding]; other site 941968013452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968013453 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968013455 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 941968013456 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941968013457 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 941968013458 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 941968013459 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 941968013460 oligomer interface [polypeptide binding]; other site 941968013461 putative active site [active] 941968013462 metal binding site [ion binding]; metal-binding site 941968013466 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 941968013467 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 941968013468 oligomer interface [polypeptide binding]; other site 941968013469 metal binding site [ion binding]; metal-binding site 941968013470 metal binding site [ion binding]; metal-binding site 941968013471 putative Cl binding site [ion binding]; other site 941968013472 aspartate ring; other site 941968013473 basic sphincter; other site 941968013474 hydrophobic gate; other site 941968013475 periplasmic entrance; other site 941968013477 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 941968013478 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 941968013480 HPr kinase/phosphorylase; Provisional; Region: PRK05428 941968013481 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 941968013482 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 941968013483 Hpr binding site; other site 941968013484 active site 941968013485 homohexamer subunit interaction site [polypeptide binding]; other site 941968013488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 941968013490 Uncharacterized conserved protein [Function unknown]; Region: COG0398 941968013491 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941968013495 Uncharacterized conserved protein [Function unknown]; Region: COG0398 941968013496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941968013499 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941968013500 Cysteine-rich domain; Region: CCG; pfam02754 941968013501 Cysteine-rich domain; Region: CCG; pfam02754 941968013505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941968013506 Phosphotransferase enzyme family; Region: APH; pfam01636 941968013507 active site 941968013508 ATP binding site [chemical binding]; other site 941968013510 1 probable transmembrane helix predicted for cbot02716 by TMHMM2.0 at aa 13-35 941968013511 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 941968013513 1 probable transmembrane helix predicted for cbot02717 by TMHMM2.0 at aa 23-45 941968013514 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 941968013515 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 941968013516 Probable Catalytic site; other site 941968013518 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 941968013519 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 941968013520 active site residue [active] 941968013521 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 941968013522 active site residue [active] 941968013528 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 941968013529 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 941968013530 putative active site [active] 941968013535 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 941968013537 1 probable transmembrane helix predicted for cbot02722 by TMHMM2.0 at aa 34-56 941968013538 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 941968013539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968013540 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968013545 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 941968013546 active site 941968013550 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941968013551 active site 941968013552 catalytic residues [active] 941968013553 metal binding site [ion binding]; metal-binding site 941968013555 1 probable transmembrane helix predicted for cbot02726 by TMHMM2.0 at aa 31-53 941968013556 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 941968013560 V-type ATP synthase subunit B; Provisional; Region: PRK04196 941968013561 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941968013562 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 941968013563 Walker A motif homologous position; other site 941968013564 Walker B motif; other site 941968013565 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941968013569 1 probable transmembrane helix predicted for cbot02728 by TMHMM2.0 at aa 20-42 941968013571 V-type ATP synthase subunit A; Provisional; Region: PRK04192 941968013572 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941968013573 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 941968013574 Walker A motif/ATP binding site; other site 941968013575 Walker B motif; other site 941968013576 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941968013585 V-type ATP synthase subunit F; Provisional; Region: PRK01395 941968013587 V-type ATP synthase subunit C; Provisional; Region: PRK01198 941968013588 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 941968013590 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 941968013591 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 941968013594 V-type ATP synthase subunit K; Validated; Region: PRK06558 941968013595 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 941968013596 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 941968013600 V-type ATP synthase subunit I; Validated; Region: PRK05771 941968013603 V-type ATP synthase subunit H; Validated; Region: PRK08404 941968013605 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 941968013606 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 941968013607 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 941968013611 1 probable transmembrane helix predicted for cbot02736 by TMHMM2.0 at aa 7-29 941968013613 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 941968013614 Zn binding site [ion binding]; other site 941968013617 1 probable transmembrane helix predicted for cbot02738 by TMHMM2.0 at aa 22-44 941968013618 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 941968013620 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968013621 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 941968013622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968013623 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968013624 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968013625 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968013632 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 941968013633 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941968013634 DRTGG domain; Region: DRTGG; pfam07085 941968013635 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941968013636 DHH family; Region: DHH; pfam01368 941968013637 DHHA2 domain; Region: DHHA2; pfam02833 941968013645 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 941968013646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941968013647 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941968013651 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 941968013652 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941968013653 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941968013655 1 probable transmembrane helix predicted for cbot02743 by TMHMM2.0 at aa 7-38 941968013659 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 941968013660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968013661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941968013662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968013663 DNA binding residues [nucleotide binding] 941968013667 1 probable transmembrane helix predicted for cbot02746 by TMHMM2.0 at aa 29-51 941968013668 Flagellar protein YcgR; Region: YcgR_2; pfam12945 941968013669 PilZ domain; Region: PilZ; pfam07238 941968013671 1 probable transmembrane helix predicted for cbot02747 by TMHMM2.0 at aa 7-29 941968013673 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 941968013674 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 941968013675 P-loop; other site 941968013677 1 probable transmembrane helix predicted for cbot02748 by TMHMM2.0 at aa 23-45 941968013679 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 941968013680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968013683 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 941968013684 FHIPEP family; Region: FHIPEP; pfam00771 941968013688 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 941968013689 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 941968013690 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 941968013695 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 941968013698 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 941968013701 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 941968013704 1 probable transmembrane helix predicted for cbot02754 by TMHMM2.0 at aa 5-27 941968013705 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 941968013707 flagellar motor protein MotS; Reviewed; Region: PRK06925 941968013708 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941968013709 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941968013710 ligand binding site [chemical binding]; other site 941968013714 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 941968013715 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 941968013717 Flagellar protein (FlbD); Region: FlbD; pfam06289 941968013719 1 probable transmembrane helix predicted for cbot02758 by TMHMM2.0 at aa 15-37 941968013721 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 941968013722 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941968013723 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941968013725 1 probable transmembrane helix predicted for cbot02759 by TMHMM2.0 at aa 35-57 941968013727 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 941968013730 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 941968013733 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 941968013735 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 941968013736 Flagellar FliJ protein; Region: FliJ; pfam02050 941968013739 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 941968013740 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941968013741 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 941968013742 Walker A motif/ATP binding site; other site 941968013743 Walker B motif; other site 941968013747 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 941968013748 FliG C-terminal domain; Region: FliG_C; pfam01706 941968013753 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 941968013754 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 941968013755 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 941968013760 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 941968013763 potential frameshift: common BLAST hit: gi|384462964|ref|YP_005675559.1| flagellar basal-body rod protein FlgC 941968013764 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941968013766 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 941968013768 1 probable transmembrane helix predicted for cbot02771 by TMHMM2.0 at aa 4-26 941968013769 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 941968013771 flagellin; Provisional; Region: PRK12804 941968013772 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968013773 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941968013776 argininosuccinate lyase; Provisional; Region: PRK00855 941968013777 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 941968013778 active sites [active] 941968013779 tetramer interface [polypeptide binding]; other site 941968013781 argininosuccinate synthase; Provisional; Region: PRK13820 941968013782 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 941968013783 ANP binding site [chemical binding]; other site 941968013784 Substrate Binding Site II [chemical binding]; other site 941968013785 Substrate Binding Site I [chemical binding]; other site 941968013787 1 probable transmembrane helix predicted for cbot02777 by TMHMM2.0 at aa 20-42 941968013788 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 941968013789 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 941968013790 putative active site [active] 941968013791 catalytic site [active] 941968013792 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 941968013793 putative active site [active] 941968013794 catalytic site [active] 941968013798 Predicted membrane protein [Function unknown]; Region: COG4129 941968013799 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 941968013802 1 probable transmembrane helix predicted for cbot02781 by TMHMM2.0 at aa 21-43 941968013804 Predicted integral membrane protein [Function unknown]; Region: COG5652 941968013806 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968013808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941968013809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968013810 NAD(P) binding site [chemical binding]; other site 941968013811 active site 941968013813 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 941968013814 NeuB family; Region: NeuB; pfam03102 941968013815 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 941968013816 NeuB binding interface [polypeptide binding]; other site 941968013817 putative substrate binding site [chemical binding]; other site 941968013822 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 941968013823 ligand binding site; other site 941968013824 tetramer interface; other site 941968013825 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 941968013826 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 941968013830 1 probable transmembrane helix predicted for cbot02788 by TMHMM2.0 at aa 20-37 941968013834 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 941968013835 1 probable transmembrane helix predicted for cbot02790 by TMHMM2.0 at aa 27-49 941968013836 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 941968013837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968013838 UDP-galactopyranose mutase; Region: GLF; pfam03275 941968013840 1 probable transmembrane helix predicted for cbot02791 by TMHMM2.0 at aa 37-59 941968013842 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 941968013843 Bacterial sugar transferase; Region: Bac_transf; pfam02397 941968013845 1 probable transmembrane helix predicted for cbot02792 by TMHMM2.0 at aa 15-37 941968013846 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 941968013847 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941968013850 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 941968013852 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 941968013853 Chain length determinant protein; Region: Wzz; cl15801 941968013856 Transcriptional regulator [Transcription]; Region: LytR; COG1316 941968013859 Putative motility protein; Region: YjfB_motility; pfam14070 941968013862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968013863 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968013864 dimer interface [polypeptide binding]; other site 941968013865 putative CheW interface [polypeptide binding]; other site 941968013868 1 probable transmembrane helix predicted for cbot02800 by TMHMM2.0 at aa 39-61 941968013869 flagellin; Provisional; Region: PRK12804 941968013870 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968013871 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941968013875 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 941968013876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968013878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 941968013880 1 probable transmembrane helix predicted for cbot02804 by TMHMM2.0 at aa 10-40 941968013882 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 941968013884 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941968013885 active site 941968013886 nucleotide binding site [chemical binding]; other site 941968013887 HIGH motif; other site 941968013888 KMSKS motif; other site 941968013889 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941968013890 tetramer interface [polypeptide binding]; other site 941968013891 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 941968013892 active site 941968013893 Mg2+/Mn2+ binding site [ion binding]; other site 941968013895 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 941968013896 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941968013897 dimer interface [polypeptide binding]; other site 941968013898 PYR/PP interface [polypeptide binding]; other site 941968013899 TPP binding site [chemical binding]; other site 941968013900 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 941968013901 TPP-binding site; other site 941968013904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968013905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968013906 catalytic residue [active] 941968013909 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 941968013910 active site 941968013911 metal-binding site 941968013913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968013914 TPR motif; other site 941968013915 Sulfatase; Region: Sulfatase; cl17466 941968013916 Sulfatase; Region: Sulfatase; cl17466 941968013922 pseudaminic acid synthase; Region: PseI; TIGR03586 941968013923 NeuB family; Region: NeuB; pfam03102 941968013924 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 941968013925 NeuB binding interface [polypeptide binding]; other site 941968013926 putative substrate binding site [chemical binding]; other site 941968013931 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 941968013932 ligand binding site; other site 941968013933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 941968013936 1 probable transmembrane helix predicted for cbot02813 by TMHMM2.0 at aa 31-50 941968013937 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 941968013938 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 941968013939 NAD(P) binding site [chemical binding]; other site 941968013940 homodimer interface [polypeptide binding]; other site 941968013941 substrate binding site [chemical binding]; other site 941968013942 active site 941968013947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 941968013950 flagellin; Provisional; Region: PRK12804 941968013951 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968013952 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941968013957 Flagellar protein FliT; Region: FliT; pfam05400 941968013958 1 probable transmembrane helix predicted for cbot02821 by TMHMM2.0 at aa 2-24 941968013959 flagellar capping protein; Validated; Region: fliD; PRK07737 941968013960 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 941968013961 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 941968013966 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 941968013968 1 probable transmembrane helix predicted for cbot02823 by TMHMM2.0 at aa 20-42 941968013971 FlaG protein; Region: FlaG; pfam03646 941968013973 1 probable transmembrane helix predicted for cbot02825 by TMHMM2.0 at aa 21-43 941968013974 carbon storage regulator; Provisional; Region: PRK01712 941968013976 flagellar assembly protein FliW; Provisional; Region: PRK13285 941968013978 1 probable transmembrane helix predicted for cbot02827 by TMHMM2.0 at aa 10-32 941968013980 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 941968013981 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941968013982 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941968013988 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 941968013989 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941968013990 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941968013996 FlgN protein; Region: FlgN; pfam05130 941968013998 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 941968014000 flagellar motor switch protein; Validated; Region: PRK08119 941968014001 CheC-like family; Region: CheC; pfam04509 941968014002 CheC-like family; Region: CheC; pfam04509 941968014003 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 941968014010 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 941968014011 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 941968014015 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941968014018 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 941968014019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968014020 active site 941968014021 phosphorylation site [posttranslational modification] 941968014022 intermolecular recognition site; other site 941968014023 dimerization interface [polypeptide binding]; other site 941968014027 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 941968014028 CheC-like family; Region: CheC; pfam04509 941968014029 CheC-like family; Region: CheC; pfam04509 941968014033 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941968014034 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941968014035 putative binding surface; other site 941968014036 active site 941968014037 P2 response regulator binding domain; Region: P2; pfam07194 941968014038 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 941968014039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968014040 ATP binding site [chemical binding]; other site 941968014041 Mg2+ binding site [ion binding]; other site 941968014042 G-X-G motif; other site 941968014043 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 941968014057 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 941968014058 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 941968014059 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 941968014063 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 941968014064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968014065 active site 941968014066 phosphorylation site [posttranslational modification] 941968014067 intermolecular recognition site; other site 941968014068 dimerization interface [polypeptide binding]; other site 941968014069 CheB methylesterase; Region: CheB_methylest; pfam01339 941968014074 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 941968014076 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941968014079 Protein of unknown function (DUF342); Region: DUF342; pfam03961 941968014084 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968014085 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 941968014086 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968014087 active site turn [active] 941968014088 phosphorylation site [posttranslational modification] 941968014089 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968014090 HPr interaction site; other site 941968014091 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968014092 active site 941968014093 phosphorylation site [posttranslational modification] 941968014100 transcriptional antiterminator BglG; Provisional; Region: PRK09772 941968014101 CAT RNA binding domain; Region: CAT_RBD; smart01061 941968014102 PRD domain; Region: PRD; pfam00874 941968014103 PRD domain; Region: PRD; pfam00874 941968014104 PRD domain; Region: PRD; pfam00874 941968014108 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941968014109 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 941968014110 homodimer interface [polypeptide binding]; other site 941968014111 substrate-cofactor binding pocket; other site 941968014112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968014113 catalytic residue [active] 941968014115 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 941968014116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968014117 motif II; other site 941968014119 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 941968014122 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 941968014123 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 941968014124 dimer interface [polypeptide binding]; other site 941968014125 PYR/PP interface [polypeptide binding]; other site 941968014126 TPP binding site [chemical binding]; other site 941968014127 substrate binding site [chemical binding]; other site 941968014128 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 941968014129 Domain of unknown function; Region: EKR; smart00890 941968014130 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968014131 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 941968014132 TPP-binding site [chemical binding]; other site 941968014133 dimer interface [polypeptide binding]; other site 941968014145 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 941968014146 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 941968014147 active site 941968014148 homodimer interface [polypeptide binding]; other site 941968014152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968014153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968014154 dimer interface [polypeptide binding]; other site 941968014155 phosphorylation site [posttranslational modification] 941968014156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968014157 ATP binding site [chemical binding]; other site 941968014158 Mg2+ binding site [ion binding]; other site 941968014159 G-X-G motif; other site 941968014164 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 941968014165 DHH family; Region: DHH; pfam01368 941968014166 DHHA1 domain; Region: DHHA1; pfam02272 941968014173 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 941968014174 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 941968014175 AP (apurinic/apyrimidinic) site pocket; other site 941968014176 DNA interaction; other site 941968014177 Metal-binding active site; metal-binding site 941968014179 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941968014180 Metal-binding active site; metal-binding site 941968014182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 941968014183 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941968014188 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941968014189 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941968014190 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941968014191 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941968014193 1 probable transmembrane helix predicted for cbot02857 by TMHMM2.0 at aa 4-26 941968014195 Predicted membrane protein [Function unknown]; Region: COG2246 941968014196 GtrA-like protein; Region: GtrA; pfam04138 941968014198 DJ-1 family protein; Region: not_thiJ; TIGR01383 941968014199 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 941968014200 conserved cys residue [active] 941968014202 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 941968014204 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 941968014205 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941968014206 CAP-like domain; other site 941968014207 active site 941968014208 primary dimer interface [polypeptide binding]; other site 941968014209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941968014217 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 941968014218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968014219 ATP binding site [chemical binding]; other site 941968014220 Mg2+ binding site [ion binding]; other site 941968014221 G-X-G motif; other site 941968014222 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941968014223 anchoring element; other site 941968014224 dimer interface [polypeptide binding]; other site 941968014225 ATP binding site [chemical binding]; other site 941968014226 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 941968014227 active site 941968014228 metal binding site [ion binding]; metal-binding site 941968014229 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941968014237 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 941968014238 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941968014240 1 probable transmembrane helix predicted for cbot02866 by TMHMM2.0 at aa 27-49 941968014242 1 probable transmembrane helix predicted for cbot02867 by TMHMM2.0 at aa 10-27 941968014243 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 941968014244 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941968014245 NodB motif; other site 941968014246 active site 941968014247 catalytic site [active] 941968014248 Zn binding site [ion binding]; other site 941968014251 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 941968014252 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 941968014253 NAD binding site [chemical binding]; other site 941968014254 homodimer interface [polypeptide binding]; other site 941968014255 active site 941968014256 substrate binding site [chemical binding]; other site 941968014258 flavodoxin; Provisional; Region: PRK05568 941968014259 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 941968014262 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968014263 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 941968014269 Cupin domain; Region: Cupin_2; cl17218 941968014270 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 941968014271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968014272 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 941968014278 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 941968014279 putative dimer interface [polypeptide binding]; other site 941968014280 catalytic triad [active] 941968014282 glycerol kinase; Provisional; Region: glpK; PRK00047 941968014283 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 941968014284 N- and C-terminal domain interface [polypeptide binding]; other site 941968014285 active site 941968014286 MgATP binding site [chemical binding]; other site 941968014287 catalytic site [active] 941968014288 metal binding site [ion binding]; metal-binding site 941968014289 glycerol binding site [chemical binding]; other site 941968014290 homotetramer interface [polypeptide binding]; other site 941968014291 homodimer interface [polypeptide binding]; other site 941968014292 FBP binding site [chemical binding]; other site 941968014293 protein IIAGlc interface [polypeptide binding]; other site 941968014298 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 941968014299 amphipathic channel; other site 941968014300 Asn-Pro-Ala signature motifs; other site 941968014305 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 941968014307 VanZ like family; Region: VanZ; pfam04892 941968014310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968014311 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968014312 Walker A/P-loop; other site 941968014313 ATP binding site [chemical binding]; other site 941968014314 Q-loop/lid; other site 941968014315 ABC transporter signature motif; other site 941968014316 Walker B; other site 941968014317 D-loop; other site 941968014318 H-loop/switch region; other site 941968014321 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968014322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968014323 DNA-binding site [nucleotide binding]; DNA binding site 941968014326 1 probable transmembrane helix predicted for cbot02881 by TMHMM2.0 at aa 31-53 941968014327 VanZ like family; Region: VanZ; cl01971 941968014329 hybrid cluster protein; Provisional; Region: PRK05290 941968014330 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968014331 ACS interaction site; other site 941968014332 CODH interaction site; other site 941968014333 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 941968014334 hybrid metal cluster; other site 941968014336 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 941968014337 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 941968014341 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 941968014342 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 941968014344 Spore germination protein; Region: Spore_permease; pfam03845 941968014346 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 941968014348 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 941968014349 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 941968014350 active site 941968014351 multimer interface [polypeptide binding]; other site 941968014354 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941968014355 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 941968014356 NodB motif; other site 941968014357 active site 941968014358 catalytic site [active] 941968014359 Zn binding site [ion binding]; other site 941968014362 1 probable transmembrane helix predicted for cbot02891 by TMHMM2.0 at aa 10-27 941968014364 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941968014365 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941968014366 ATP binding site [chemical binding]; other site 941968014367 Mg++ binding site [ion binding]; other site 941968014368 motif III; other site 941968014369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968014370 nucleotide binding region [chemical binding]; other site 941968014371 ATP-binding site [chemical binding]; other site 941968014372 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 941968014373 RNA binding site [nucleotide binding]; other site 941968014379 Probable zinc-binding domain; Region: zf-trcl; pfam13451 941968014380 1 probable transmembrane helix predicted for cbot02893 by TMHMM2.0 at aa 15-37 941968014381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968014382 dimer interface [polypeptide binding]; other site 941968014383 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 941968014384 putative CheW interface [polypeptide binding]; other site 941968014390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941968014391 Ligand Binding Site [chemical binding]; other site 941968014393 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 941968014394 4Fe-4S binding domain; Region: Fer4_5; pfam12801 941968014395 4Fe-4S binding domain; Region: Fer4; cl02805 941968014397 glutaminase; Provisional; Region: PRK00971 941968014398 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 941968014401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 941968014402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941968014407 1 probable transmembrane helix predicted for cbot02900 by TMHMM2.0 at aa 4-26 941968014409 Cache domain; Region: Cache_1; pfam02743 941968014410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968014411 dimerization interface [polypeptide binding]; other site 941968014412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968014413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968014414 dimer interface [polypeptide binding]; other site 941968014415 putative CheW interface [polypeptide binding]; other site 941968014427 TraX protein; Region: TraX; cl05434 941968014429 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 941968014430 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 941968014431 dimer interface [polypeptide binding]; other site 941968014432 putative radical transfer pathway; other site 941968014433 diiron center [ion binding]; other site 941968014434 tyrosyl radical; other site 941968014436 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 941968014437 ATP cone domain; Region: ATP-cone; pfam03477 941968014438 Class I ribonucleotide reductase; Region: RNR_I; cd01679 941968014439 active site 941968014440 dimer interface [polypeptide binding]; other site 941968014441 catalytic residues [active] 941968014442 effector binding site; other site 941968014443 R2 peptide binding site; other site 941968014444 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 941968014446 1 probable transmembrane helix predicted for cbot02904 by TMHMM2.0 at aa 26-48 941968014451 Putative amidase domain; Region: Amidase_6; pfam12671 941968014454 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 941968014456 DNA polymerase IV; Provisional; Region: PRK14133 941968014457 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 941968014458 active site 941968014459 DNA binding site [nucleotide binding] 941968014464 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 941968014465 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 941968014466 homodimer interface [polypeptide binding]; other site 941968014467 active site 941968014468 FMN binding site [chemical binding]; other site 941968014469 substrate binding site [chemical binding]; other site 941968014470 4Fe-4S binding domain; Region: Fer4; pfam00037 941968014473 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 941968014474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968014479 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 941968014480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968014481 active site 941968014485 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941968014486 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941968014487 putative active site [active] 941968014490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968014491 MarR family; Region: MarR_2; pfam12802 941968014494 1 probable transmembrane helix predicted for cbot02913 by TMHMM2.0 at aa 12-34 941968014496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968014497 Walker A/P-loop; other site 941968014498 ATP binding site [chemical binding]; other site 941968014499 Q-loop/lid; other site 941968014500 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941968014501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968014502 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 941968014503 Walker A/P-loop; other site 941968014504 ATP binding site [chemical binding]; other site 941968014505 Q-loop/lid; other site 941968014506 ABC transporter signature motif; other site 941968014507 Walker B; other site 941968014508 D-loop; other site 941968014509 H-loop/switch region; other site 941968014513 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 941968014515 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 941968014516 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941968014517 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941968014519 Carbohydrate binding domain; Region: CBM_25; smart01066 941968014522 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941968014523 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 941968014524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968014525 dimerization interface [polypeptide binding]; other site 941968014526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968014527 dimer interface [polypeptide binding]; other site 941968014528 putative CheW interface [polypeptide binding]; other site 941968014537 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 941968014538 nudix motif; other site 941968014541 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941968014542 metal binding site 2 [ion binding]; metal-binding site 941968014543 putative DNA binding helix; other site 941968014544 metal binding site 1 [ion binding]; metal-binding site 941968014545 dimer interface [polypeptide binding]; other site 941968014546 structural Zn2+ binding site [ion binding]; other site 941968014548 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 941968014551 Glyco_18 domain; Region: Glyco_18; smart00636 941968014552 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 941968014553 active site 941968014554 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 941968014558 1 probable transmembrane helix predicted for cbot02922 by TMHMM2.0 at aa 9-28 941968014560 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 941968014561 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 941968014562 active site 941968014563 trimer interface [polypeptide binding]; other site 941968014564 allosteric site; other site 941968014565 active site lid [active] 941968014567 1 probable transmembrane helix predicted for cbot02923 by TMHMM2.0 at aa 38-60 941968014568 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 941968014569 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 941968014570 active site 941968014571 dimer interface [polypeptide binding]; other site 941968014573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941968014574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968014575 DNA-binding site [nucleotide binding]; DNA binding site 941968014576 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 941968014582 transcriptional antiterminator BglG; Provisional; Region: PRK09772 941968014583 CAT RNA binding domain; Region: CAT_RBD; smart01061 941968014584 PRD domain; Region: PRD; pfam00874 941968014585 PRD domain; Region: PRD; pfam00874 941968014588 1 probable transmembrane helix predicted for cbot02926 by TMHMM2.0 at aa 13-35 941968014591 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941968014592 HPr interaction site; other site 941968014593 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941968014594 active site 941968014595 phosphorylation site [posttranslational modification] 941968014598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941968014599 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 941968014600 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941968014601 active site turn [active] 941968014602 phosphorylation site [posttranslational modification] 941968014606 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 941968014607 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968014610 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968014611 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 941968014612 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941968014613 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941968014617 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 941968014618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968014619 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941968014623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941968014624 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 941968014625 FAD binding site [chemical binding]; other site 941968014626 homotetramer interface [polypeptide binding]; other site 941968014627 substrate binding pocket [chemical binding]; other site 941968014628 catalytic base [active] 941968014629 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941968014630 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941968014631 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 941968014632 Rubredoxin; Region: Rubredoxin; pfam00301 941968014633 iron binding site [ion binding]; other site 941968014641 HTH-like domain; Region: HTH_21; pfam13276 941968014642 Integrase core domain; Region: rve; pfam00665 941968014643 Integrase core domain; Region: rve_2; pfam13333 941968014645 Helix-turn-helix domain; Region: HTH_28; pfam13518 941968014646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 941968014647 Transposase; Region: HTH_Tnp_1; cl17663 941968014648 Helix-turn-helix domain; Region: HTH_28; pfam13518 941968014649 Winged helix-turn helix; Region: HTH_29; pfam13551 941968014652 1 probable transmembrane helix predicted for cbot02935 by TMHMM2.0 at aa 20-42 941968014653 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 941968014654 active site 941968014655 phosphorylation site [posttranslational modification] 941968014657 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 941968014659 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 941968014661 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 941968014664 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 941968014666 1 probable transmembrane helix predicted for cbot02940 by TMHMM2.0 at aa 136-158 941968014667 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 941968014669 Domain of unknown function (DUF956); Region: DUF956; pfam06115 941968014671 1 probable transmembrane helix predicted for cbot02942 by TMHMM2.0 at aa 4-21 941968014672 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 941968014676 1 probable transmembrane helix predicted for cbot02943 by TMHMM2.0 at aa 36-58 941968014677 Coenzyme A transferase; Region: CoA_trans; cl17247 941968014680 1 probable transmembrane helix predicted for cbot02944 by TMHMM2.0 at aa 5-27 941968014683 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 941968014684 Ligand binding site; other site 941968014685 metal-binding site 941968014687 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 941968014688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941968014689 catalytic loop [active] 941968014690 iron binding site [ion binding]; other site 941968014691 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941968014694 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 941968014695 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 941968014698 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 941968014699 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941968014700 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941968014705 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 941968014706 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 941968014708 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941968014709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968014710 motif II; other site 941968014713 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 941968014714 amidase catalytic site [active] 941968014715 Zn binding residues [ion binding]; other site 941968014716 substrate binding site [chemical binding]; other site 941968014720 1 probable transmembrane helix predicted for cbot02952 by TMHMM2.0 at aa 17-39 941968014721 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 941968014722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968014723 FeS/SAM binding site; other site 941968014726 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941968014727 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968014728 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968014733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968014734 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968014735 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941968014737 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941968014738 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941968014740 TRAM domain; Region: TRAM; pfam01938 941968014741 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 941968014742 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 941968014743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968014744 S-adenosylmethionine binding site [chemical binding]; other site 941968014749 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 941968014750 Sulfatase; Region: Sulfatase; pfam00884 941968014752 hypothetical protein; Provisional; Region: PRK10621 941968014753 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941968014757 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 941968014758 homopentamer interface [polypeptide binding]; other site 941968014759 active site 941968014761 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 941968014762 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 941968014763 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 941968014764 dimerization interface [polypeptide binding]; other site 941968014765 active site 941968014768 1 probable transmembrane helix predicted for cbot02964 by TMHMM2.0 at aa 20-42 941968014772 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 941968014773 Lumazine binding domain; Region: Lum_binding; pfam00677 941968014774 Lumazine binding domain; Region: Lum_binding; pfam00677 941968014778 1 probable transmembrane helix predicted for cbot02965 by TMHMM2.0 at aa 12-31 941968014779 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 941968014780 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 941968014781 catalytic motif [active] 941968014782 Zn binding site [ion binding]; other site 941968014783 RibD C-terminal domain; Region: RibD_C; cl17279 941968014787 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 941968014788 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 941968014789 metal binding site [ion binding]; metal-binding site 941968014790 dimer interface [polypeptide binding]; other site 941968014794 1 probable transmembrane helix predicted for cbot02967 by TMHMM2.0 at aa 7-29 941968014796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968014799 magnesium-transporting ATPase; Provisional; Region: PRK15122 941968014800 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 941968014801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968014802 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968014803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968014804 motif II; other site 941968014805 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941968014811 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 941968014812 active site 941968014813 1 probable transmembrane helix predicted for cbot02970 by TMHMM2.0 at aa 10-32 941968014814 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 941968014815 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 941968014816 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 941968014817 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 941968014821 1 probable transmembrane helix predicted for cbot02971 by TMHMM2.0 at aa 7-29 941968014823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 941968014824 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 941968014825 purine monophosphate binding site [chemical binding]; other site 941968014826 dimer interface [polypeptide binding]; other site 941968014827 putative catalytic residues [active] 941968014828 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 941968014829 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 941968014836 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 941968014837 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 941968014838 active site 941968014839 substrate binding site [chemical binding]; other site 941968014840 cosubstrate binding site; other site 941968014841 catalytic site [active] 941968014843 1 probable transmembrane helix predicted for cbot02973 by TMHMM2.0 at aa 16-35 941968014846 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 941968014847 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 941968014848 dimerization interface [polypeptide binding]; other site 941968014849 putative ATP binding site [chemical binding]; other site 941968014852 amidophosphoribosyltransferase; Provisional; Region: PRK05793 941968014853 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 941968014854 active site 941968014855 tetramer interface [polypeptide binding]; other site 941968014856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968014857 active site 941968014861 1 probable transmembrane helix predicted for cbot02975 by TMHMM2.0 at aa 15-37 941968014862 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 941968014863 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 941968014864 ATP binding site [chemical binding]; other site 941968014865 active site 941968014866 substrate binding site [chemical binding]; other site 941968014868 1 probable transmembrane helix predicted for cbot02976 by TMHMM2.0 at aa 18-40 941968014870 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 941968014872 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 941968014873 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941968014874 catalytic loop [active] 941968014875 iron binding site [ion binding]; other site 941968014876 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 941968014877 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 941968014878 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 941968014886 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 941968014887 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 941968014888 putative metal binding site [ion binding]; other site 941968014889 putative dimer interface [polypeptide binding]; other site 941968014892 1 probable transmembrane helix predicted for cbot02979 by TMHMM2.0 at aa 79-98 941968014893 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 941968014894 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 941968014895 active site 941968014896 putative substrate binding pocket [chemical binding]; other site 941968014898 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 941968014899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968014904 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 941968014905 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941968014906 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941968014909 1 probable transmembrane helix predicted for cbot02982 by TMHMM2.0 at aa 98-120 941968014911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968014912 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968014913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968014914 active site 941968014916 xanthine permease; Region: pbuX; TIGR03173 941968014921 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 941968014922 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 941968014923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968014924 catalytic residue [active] 941968014927 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 941968014928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968014929 Walker A motif; other site 941968014930 ATP binding site [chemical binding]; other site 941968014931 Walker B motif; other site 941968014932 arginine finger; other site 941968014933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968014934 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968014936 1 probable transmembrane helix predicted for cbot02988 by TMHMM2.0 at aa 4-23 941968014939 1 probable transmembrane helix predicted for cbot02989 by TMHMM2.0 at aa 15-32 941968014940 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 941968014941 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 941968014942 Ligand binding site; other site 941968014943 metal-binding site 941968014945 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 941968014946 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 941968014947 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 941968014948 XdhC Rossmann domain; Region: XdhC_C; pfam13478 941968014950 NTPase; Region: NTPase_1; pfam03266 941968014951 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941968014953 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941968014954 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941968014955 ABC-ATPase subunit interface; other site 941968014956 dimer interface [polypeptide binding]; other site 941968014957 putative PBP binding regions; other site 941968014960 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941968014961 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941968014962 Walker A/P-loop; other site 941968014963 ATP binding site [chemical binding]; other site 941968014964 Q-loop/lid; other site 941968014965 ABC transporter signature motif; other site 941968014966 Walker B; other site 941968014967 D-loop; other site 941968014968 H-loop/switch region; other site 941968014971 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941968014972 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968014973 intersubunit interface [polypeptide binding]; other site 941968014976 ALIX V-shaped domain binding to HIV; Region: ALIX_LYPXL_bnd; pfam13949 941968014978 1 probable transmembrane helix predicted for cbot02998 by TMHMM2.0 at aa 4-21 941968014979 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 941968014980 active site 941968014981 catalytic triad [active] 941968014982 oxyanion hole [active] 941968014984 Uncharacterized conserved protein [Function unknown]; Region: COG1434 941968014985 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 941968014986 putative active site [active] 941968014988 1 probable transmembrane helix predicted for cbot03000 by TMHMM2.0 at aa 12-34 941968014991 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941968014996 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 941968014997 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 941968015001 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 941968015002 Part of AAA domain; Region: AAA_19; pfam13245 941968015005 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 941968015006 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 941968015007 Ligand Binding Site [chemical binding]; other site 941968015010 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 941968015011 putative metal binding site [ion binding]; other site 941968015012 putative dimer interface [polypeptide binding]; other site 941968015016 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 941968015017 GAF domain; Region: GAF_2; pfam13185 941968015019 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941968015020 Domain of unknown function DUF21; Region: DUF21; pfam01595 941968015021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941968015022 Transporter associated domain; Region: CorC_HlyC; pfam03471 941968015028 Domain of unknown function DUF77; Region: DUF77; pfam01910 941968015031 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 941968015032 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 941968015037 amidophosphoribosyltransferase; Provisional; Region: PRK05793 941968015038 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 941968015039 active site 941968015040 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968015041 active site 941968015044 1 probable transmembrane helix predicted for cbot03010 by TMHMM2.0 at aa 21-43 941968015045 Protein of unknown function (DUF503); Region: DUF503; pfam04456 941968015047 1 probable transmembrane helix predicted for cbot03011 by TMHMM2.0 at aa 15-37 941968015048 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 941968015049 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 941968015050 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968015051 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968015052 Walker A/P-loop; other site 941968015053 ATP binding site [chemical binding]; other site 941968015054 Q-loop/lid; other site 941968015055 ABC transporter signature motif; other site 941968015056 Walker B; other site 941968015057 D-loop; other site 941968015058 H-loop/switch region; other site 941968015062 Predicted transcriptional regulators [Transcription]; Region: COG1725 941968015063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968015064 DNA-binding site [nucleotide binding]; DNA binding site 941968015068 Ferredoxin [Energy production and conversion]; Region: COG1146 941968015069 4Fe-4S binding domain; Region: Fer4_6; pfam12837 941968015070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941968015071 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 941968015072 1 probable transmembrane helix predicted for cbot03018 by TMHMM2.0 at aa 10-32 941968015073 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941968015075 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 941968015077 1 probable transmembrane helix predicted for cbot03021 by TMHMM2.0 at aa 13-35 941968015078 Predicted membrane protein [Function unknown]; Region: COG1511 941968015079 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941968015080 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941968015086 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941968015087 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 941968015088 active site 941968015089 catalytic site [active] 941968015090 metal binding site [ion binding]; metal-binding site 941968015091 dimer interface [polypeptide binding]; other site 941968015093 1 probable transmembrane helix predicted for cbot03023 by TMHMM2.0 at aa 5-27 941968015094 potential frameshift: common BLAST hit: gi|384463189|ref|YP_005675784.1| TPR domain-containing protein 941968015096 1 probable transmembrane helix predicted for cbot03025 by TMHMM2.0 at aa 10-29 941968015098 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 941968015099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968015100 catalytic residue [active] 941968015103 1 probable transmembrane helix predicted for cbot03027 by TMHMM2.0 at aa 5-24 941968015104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 941968015106 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 941968015107 Putative zinc ribbon domain; Region: DUF164; pfam02591 941968015109 1 probable transmembrane helix predicted for cbot03029 by TMHMM2.0 at aa 66-88 941968015110 Uncharacterized conserved protein [Function unknown]; Region: COG0327 941968015111 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 941968015113 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 941968015114 Family of unknown function (DUF633); Region: DUF633; pfam04816 941968015116 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 941968015118 1 probable transmembrane helix predicted for cbot03033 by TMHMM2.0 at aa 7-29 941968015119 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 941968015120 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 941968015121 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941968015122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968015123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941968015124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968015125 DNA binding residues [nucleotide binding] 941968015133 1 probable transmembrane helix predicted for cbot03034 by TMHMM2.0 at aa 5-27 941968015135 DNA primase, catalytic core; Region: dnaG; TIGR01391 941968015136 CHC2 zinc finger; Region: zf-CHC2; pfam01807 941968015137 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 941968015138 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 941968015139 active site 941968015140 metal binding site [ion binding]; metal-binding site 941968015141 interdomain interaction site; other site 941968015142 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 941968015150 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 941968015151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968015152 Zn2+ binding site [ion binding]; other site 941968015153 Mg2+ binding site [ion binding]; other site 941968015154 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 941968015158 potential frameshift: common BLAST hit: gi|153935661|ref|YP_001388670.1| spore coat protein-like protein 941968015159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941968015160 active site 941968015161 ATP binding site [chemical binding]; other site 941968015162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 941968015163 substrate binding site [chemical binding]; other site 941968015164 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 941968015166 pyruvate phosphate dikinase; Provisional; Region: PRK09279 941968015167 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 941968015168 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941968015169 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941968015178 HTH domain; Region: HTH_11; pfam08279 941968015179 FOG: CBS domain [General function prediction only]; Region: COG0517 941968015180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 941968015189 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 941968015190 Recombination protein O C terminal; Region: RecO_C; pfam02565 941968015192 GTPase Era; Reviewed; Region: era; PRK00089 941968015193 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 941968015194 G1 box; other site 941968015195 GTP/Mg2+ binding site [chemical binding]; other site 941968015196 Switch I region; other site 941968015197 G2 box; other site 941968015198 Switch II region; other site 941968015199 G3 box; other site 941968015200 G4 box; other site 941968015201 G5 box; other site 941968015204 1 probable transmembrane helix predicted for cbot03043 by TMHMM2.0 at aa 7-29 941968015206 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 941968015207 active site 941968015208 catalytic motif [active] 941968015209 Zn binding site [ion binding]; other site 941968015211 1 probable transmembrane helix predicted for cbot03044 by TMHMM2.0 at aa 4-26 941968015212 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 941968015213 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 941968015214 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941968015215 active site 941968015219 metal-binding heat shock protein; Provisional; Region: PRK00016 941968015221 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 941968015222 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 941968015223 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968015224 Zn2+ binding site [ion binding]; other site 941968015225 Mg2+ binding site [ion binding]; other site 941968015231 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 941968015232 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 941968015235 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 941968015237 1 probable transmembrane helix predicted for cbot03049 by TMHMM2.0 at aa 55-73 941968015239 Yqey-like protein; Region: YqeY; pfam09424 941968015242 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 941968015244 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 941968015245 nucleotide binding site/active site [active] 941968015246 HIT family signature motif; other site 941968015247 catalytic residue [active] 941968015249 1 probable transmembrane helix predicted for cbot03052 by TMHMM2.0 at aa 13-35 941968015250 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 941968015251 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941968015252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968015253 FeS/SAM binding site; other site 941968015257 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 941968015258 RNA methyltransferase, RsmE family; Region: TIGR00046 941968015261 potential frameshift: common BLAST hit: gi|226950383|ref|YP_002805474.1| ribosomal protein L11 methyltransferase 941968015262 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 941968015263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968015264 S-adenosylmethionine binding site [chemical binding]; other site 941968015266 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 941968015268 chaperone protein DnaJ; Provisional; Region: PRK14297 941968015269 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941968015270 HSP70 interaction site [polypeptide binding]; other site 941968015271 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 941968015272 substrate binding site [polypeptide binding]; other site 941968015273 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 941968015274 Zn binding sites [ion binding]; other site 941968015275 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 941968015276 dimer interface [polypeptide binding]; other site 941968015283 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 941968015284 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 941968015285 nucleotide binding site [chemical binding]; other site 941968015286 NEF interaction site [polypeptide binding]; other site 941968015287 SBD interface [polypeptide binding]; other site 941968015291 GrpE; Region: GrpE; pfam01025 941968015292 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 941968015293 dimer interface [polypeptide binding]; other site 941968015294 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 941968015297 1 probable transmembrane helix predicted for cbot03059 by TMHMM2.0 at aa 15-37 941968015299 HrcA protein C terminal domain; Region: HrcA; pfam01628 941968015301 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 941968015302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 941968015303 DNA-binding site [nucleotide binding]; DNA binding site 941968015306 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 941968015307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968015308 FeS/SAM binding site; other site 941968015309 HemN C-terminal domain; Region: HemN_C; pfam06969 941968015314 GTP-binding protein LepA; Provisional; Region: PRK05433 941968015315 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 941968015316 G1 box; other site 941968015317 putative GEF interaction site [polypeptide binding]; other site 941968015318 GTP/Mg2+ binding site [chemical binding]; other site 941968015319 Switch I region; other site 941968015320 G2 box; other site 941968015321 G3 box; other site 941968015322 Switch II region; other site 941968015323 G4 box; other site 941968015324 G5 box; other site 941968015325 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 941968015326 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 941968015327 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 941968015337 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 941968015338 stage II sporulation protein P; Region: spore_II_P; TIGR02867 941968015341 1 probable transmembrane helix predicted for cbot03065 by TMHMM2.0 at aa 4-26 941968015343 germination protease; Provisional; Region: PRK12362 941968015347 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 941968015350 1 probable transmembrane helix predicted for cbot03067 by TMHMM2.0 at aa 26-48 941968015351 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 941968015352 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 941968015354 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 941968015355 Competence protein; Region: Competence; pfam03772 941968015356 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 941968015357 Competence protein; Region: Competence; pfam03772 941968015359 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968015360 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941968015361 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941968015362 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 941968015363 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941968015364 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941968015368 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 941968015369 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 941968015375 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 941968015376 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 941968015377 G1 box; other site 941968015378 putative GEF interaction site [polypeptide binding]; other site 941968015379 GTP/Mg2+ binding site [chemical binding]; other site 941968015380 Switch I region; other site 941968015381 G2 box; other site 941968015382 G3 box; other site 941968015383 Switch II region; other site 941968015384 G4 box; other site 941968015385 G5 box; other site 941968015386 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 941968015387 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 941968015388 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 941968015389 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 941968015397 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 941968015398 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 941968015399 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 941968015401 1 probable transmembrane helix predicted for cbot03080 by TMHMM2.0 at aa 33-55 941968015404 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 941968015405 dimerization interface [polypeptide binding]; other site 941968015406 putative ATP binding site [chemical binding]; other site 941968015409 SLBB domain; Region: SLBB; pfam10531 941968015410 Helix-hairpin-helix motif; Region: HHH; pfam00633 941968015415 1 probable transmembrane helix predicted for cbot03082 by TMHMM2.0 at aa 10-32 941968015417 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941968015418 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 941968015420 1 probable transmembrane helix predicted for cbot03083 by TMHMM2.0 at aa 3-25 941968015423 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941968015424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968015425 RNA binding surface [nucleotide binding]; other site 941968015426 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941968015427 active site 941968015429 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941968015430 homotrimer interaction site [polypeptide binding]; other site 941968015431 putative active site [active] 941968015434 Transcriptional regulator [Transcription]; Region: LytR; COG1316 941968015435 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 941968015437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968015438 Zn2+ binding site [ion binding]; other site 941968015439 Mg2+ binding site [ion binding]; other site 941968015442 1 probable transmembrane helix predicted for cbot03087 by TMHMM2.0 at aa 7-26 941968015443 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 941968015444 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 941968015445 active site 941968015446 (T/H)XGH motif; other site 941968015448 1 probable transmembrane helix predicted for cbot03088 by TMHMM2.0 at aa 13-35 941968015450 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 941968015452 GTPase CgtA; Reviewed; Region: obgE; PRK12297 941968015453 GTP1/OBG; Region: GTP1_OBG; pfam01018 941968015454 Obg GTPase; Region: Obg; cd01898 941968015455 G1 box; other site 941968015456 GTP/Mg2+ binding site [chemical binding]; other site 941968015457 Switch I region; other site 941968015458 G2 box; other site 941968015459 G3 box; other site 941968015460 Switch II region; other site 941968015461 G4 box; other site 941968015462 G5 box; other site 941968015463 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 941968015468 1 probable transmembrane helix predicted for cbot03090 by TMHMM2.0 at aa 12-34 941968015471 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 941968015473 1 probable transmembrane helix predicted for cbot03091 by TMHMM2.0 at aa 12-34 941968015475 hypothetical protein; Provisional; Region: PRK14553 941968015477 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 941968015480 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 941968015481 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 941968015482 homodimer interface [polypeptide binding]; other site 941968015483 oligonucleotide binding site [chemical binding]; other site 941968015486 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 941968015487 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 941968015490 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 941968015491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968015492 FeS/SAM binding site; other site 941968015498 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 941968015499 Peptidase family M50; Region: Peptidase_M50; pfam02163 941968015500 active site 941968015501 putative substrate binding region [chemical binding]; other site 941968015503 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941968015504 Peptidase family M23; Region: Peptidase_M23; pfam01551 941968015506 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 941968015509 cell division topological specificity factor MinE; Provisional; Region: PRK13987 941968015511 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 941968015512 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 941968015513 Switch I; other site 941968015514 Switch II; other site 941968015519 septum formation inhibitor; Reviewed; Region: minC; PRK00513 941968015520 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 941968015522 1 probable transmembrane helix predicted for cbot03102 by TMHMM2.0 at aa 20-42 941968015523 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941968015524 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941968015525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941968015526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941968015533 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 941968015536 rod shape-determining protein MreC; Provisional; Region: PRK13922 941968015537 rod shape-determining protein MreC; Region: MreC; pfam04085 941968015539 rod shape-determining protein MreB; Provisional; Region: PRK13927 941968015540 MreB and similar proteins; Region: MreB_like; cd10225 941968015541 nucleotide binding site [chemical binding]; other site 941968015542 Mg binding site [ion binding]; other site 941968015543 putative protofilament interaction site [polypeptide binding]; other site 941968015544 RodZ interaction site [polypeptide binding]; other site 941968015548 hypothetical protein; Reviewed; Region: PRK00024 941968015549 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 941968015550 helix-hairpin-helix signature motif; other site 941968015551 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 941968015552 MPN+ (JAMM) motif; other site 941968015553 Zinc-binding site [ion binding]; other site 941968015555 1 probable transmembrane helix predicted for cbot03107 by TMHMM2.0 at aa 34-56 941968015556 Maf-like protein; Reviewed; Region: PRK00078 941968015557 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 941968015558 active site 941968015559 dimer interface [polypeptide binding]; other site 941968015561 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 941968015562 1 probable transmembrane helix predicted for cbot03109 by TMHMM2.0 at aa 2-19 941968015563 Sporulation related domain; Region: SPOR; cl10051 941968015565 1 probable transmembrane helix predicted for cbot03111 by TMHMM2.0 at aa 7-29 941968015566 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 941968015568 hypothetical protein; Provisional; Region: PRK04435 941968015569 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 941968015570 DNA-binding interface [nucleotide binding]; DNA binding site 941968015571 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 941968015572 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941968015573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941968015574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941968015575 catalytic residue [active] 941968015578 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 941968015579 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 941968015580 CoA-binding site [chemical binding]; other site 941968015581 ATP-binding [chemical binding]; other site 941968015583 DNA polymerase I; Provisional; Region: PRK05755 941968015584 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 941968015585 active site 941968015586 metal binding site 1 [ion binding]; metal-binding site 941968015587 putative 5' ssDNA interaction site; other site 941968015588 metal binding site 3; metal-binding site 941968015589 metal binding site 2 [ion binding]; metal-binding site 941968015590 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 941968015591 putative DNA binding site [nucleotide binding]; other site 941968015592 putative metal binding site [ion binding]; other site 941968015593 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 941968015594 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 941968015595 active site 941968015596 DNA binding site [nucleotide binding] 941968015597 catalytic site [active] 941968015608 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 941968015609 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 941968015610 Tetramer interface [polypeptide binding]; other site 941968015611 active site 941968015612 FMN-binding site [chemical binding]; other site 941968015614 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968015615 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968015616 active site 941968015617 metal binding site [ion binding]; metal-binding site 941968015618 Bacterial SH3 domain; Region: SH3_3; pfam08239 941968015624 Haemolysin XhlA; Region: XhlA; pfam10779 941968015625 1 probable transmembrane helix predicted for cbot03123 by TMHMM2.0 at aa 61-83 941968015626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941968015627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968015628 non-specific DNA binding site [nucleotide binding]; other site 941968015629 salt bridge; other site 941968015630 sequence-specific DNA binding site [nucleotide binding]; other site 941968015633 1 probable transmembrane helix predicted for cbot03127 by TMHMM2.0 at aa 20-42 941968015634 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 941968015637 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941968015639 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 941968015641 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 941968015642 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 941968015643 dimer interface [polypeptide binding]; other site 941968015644 anticodon binding site; other site 941968015645 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941968015646 homodimer interface [polypeptide binding]; other site 941968015647 motif 1; other site 941968015648 active site 941968015649 motif 2; other site 941968015650 GAD domain; Region: GAD; pfam02938 941968015651 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941968015652 motif 3; other site 941968015657 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 941968015658 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941968015659 dimer interface [polypeptide binding]; other site 941968015660 motif 1; other site 941968015661 active site 941968015662 motif 2; other site 941968015663 motif 3; other site 941968015664 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 941968015665 anticodon binding site; other site 941968015669 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 941968015670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968015671 FeS/SAM binding site; other site 941968015676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941968015679 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 941968015680 putative active site [active] 941968015681 dimerization interface [polypeptide binding]; other site 941968015682 putative tRNAtyr binding site [nucleotide binding]; other site 941968015684 1 probable transmembrane helix predicted for cbot03140 by TMHMM2.0 at aa 25-47 941968015685 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941968015686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968015687 Zn2+ binding site [ion binding]; other site 941968015688 Mg2+ binding site [ion binding]; other site 941968015689 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941968015690 synthetase active site [active] 941968015691 NTP binding site [chemical binding]; other site 941968015692 metal binding site [ion binding]; metal-binding site 941968015693 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 941968015694 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 941968015703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968015704 active site 941968015706 1 probable transmembrane helix predicted for cbot03142 by TMHMM2.0 at aa 26-48 941968015707 DHH family; Region: DHH; pfam01368 941968015709 1 probable transmembrane helix predicted for cbot03143 by TMHMM2.0 at aa 15-37 941968015710 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 941968015711 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941968015712 Protein export membrane protein; Region: SecD_SecF; pfam02355 941968015716 protein-export membrane protein SecD; Region: secD; TIGR01129 941968015717 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 941968015723 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 941968015724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968015725 FeS/SAM binding site; other site 941968015726 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 941968015730 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 941968015731 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 941968015732 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 941968015734 1 probable transmembrane helix predicted for cbot03149 by TMHMM2.0 at aa 4-26 941968015735 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 941968015736 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 941968015740 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 941968015741 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 941968015744 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 941968015745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968015746 Walker A motif; other site 941968015747 ATP binding site [chemical binding]; other site 941968015748 Walker B motif; other site 941968015749 arginine finger; other site 941968015750 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 941968015755 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 941968015756 RuvA N terminal domain; Region: RuvA_N; pfam01330 941968015757 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 941968015760 1 probable transmembrane helix predicted for cbot03153 by TMHMM2.0 at aa 4-23 941968015762 hypothetical protein; Validated; Region: PRK00110 941968015765 Uncharacterized conserved protein [Function unknown]; Region: COG1739 941968015766 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 941968015767 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 941968015772 HEAT repeats; Region: HEAT_2; pfam13646 941968015773 HEAT-like repeat; Region: HEAT_EZ; pfam13513 941968015778 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 941968015779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941968015780 DNA-binding site [nucleotide binding]; DNA binding site 941968015781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968015782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968015783 homodimer interface [polypeptide binding]; other site 941968015784 catalytic residue [active] 941968015788 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 941968015789 active site 941968015790 NTP binding site [chemical binding]; other site 941968015791 metal binding triad [ion binding]; metal-binding site 941968015792 antibiotic binding site [chemical binding]; other site 941968015795 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 941968015796 Rubredoxin; Region: Rubredoxin; pfam00301 941968015797 iron binding site [ion binding]; other site 941968015800 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 941968015801 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 941968015802 HflX GTPase family; Region: HflX; cd01878 941968015803 G1 box; other site 941968015804 GTP/Mg2+ binding site [chemical binding]; other site 941968015805 Switch I region; other site 941968015806 G2 box; other site 941968015807 G3 box; other site 941968015808 Switch II region; other site 941968015809 G4 box; other site 941968015810 G5 box; other site 941968015814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968015815 active site 941968015817 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 941968015819 1 probable transmembrane helix predicted for cbot03164 by TMHMM2.0 at aa 10-32 941968015820 Transglycosylase; Region: Transgly; pfam00912 941968015821 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 941968015822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941968015827 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 941968015829 stage V sporulation protein AD; Validated; Region: PRK08304 941968015830 stage V sporulation protein AD; Provisional; Region: PRK12404 941968015833 SpoVA protein; Region: SpoVA; cl04298 941968015836 sporulation sigma factor SigF; Validated; Region: PRK05572 941968015837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968015838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941968015839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968015840 DNA binding residues [nucleotide binding] 941968015844 anti-sigma F factor; Provisional; Region: PRK03660 941968015845 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 941968015846 ATP binding site [chemical binding]; other site 941968015847 Mg2+ binding site [ion binding]; other site 941968015848 G-X-G motif; other site 941968015850 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 941968015851 anti sigma factor interaction site; other site 941968015852 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941968015853 regulatory phosphorylation site [posttranslational modification]; other site 941968015855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941968015856 potential frameshift: common BLAST hit: gi|237796546|ref|YP_002864098.1| modification methylase family protein 941968015857 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 941968015860 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 941968015861 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 941968015862 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 941968015863 NodB motif; other site 941968015864 active site 941968015865 catalytic site [active] 941968015866 Cd binding site [ion binding]; other site 941968015869 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 941968015870 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 941968015872 1 probable transmembrane helix predicted for cbot03175 by TMHMM2.0 at aa 60-82 941968015874 Bacterial sugar transferase; Region: Bac_transf; pfam02397 941968015877 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 941968015878 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 941968015881 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 941968015882 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 941968015885 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 941968015886 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 941968015887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968015889 1 probable transmembrane helix predicted for cbot03180 by TMHMM2.0 at aa 34-51 941968015890 potential frameshift: common BLAST hit: gi|226950527|ref|YP_002805618.1| group 1 glycosyl transferase family 941968015891 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968015892 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 941968015893 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 941968015895 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 941968015896 O-Antigen ligase; Region: Wzy_C; pfam04932 941968015898 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 941968015899 putative glycosyl transferase; Provisional; Region: PRK10307 941968015902 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 941968015903 active site 941968015904 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 941968015905 homodimer interface [polypeptide binding]; other site 941968015907 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 941968015908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968015911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968015914 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 941968015915 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968015916 Leucine-rich repeats; other site 941968015917 Substrate binding site [chemical binding]; other site 941968015918 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968015919 Leucine rich repeat; Region: LRR_8; pfam13855 941968015920 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 941968015933 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 941968015934 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 941968015938 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 941968015939 putative trimer interface [polypeptide binding]; other site 941968015940 putative CoA binding site [chemical binding]; other site 941968015941 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 941968015942 putative trimer interface [polypeptide binding]; other site 941968015943 putative active site [active] 941968015944 putative substrate binding site [chemical binding]; other site 941968015945 putative CoA binding site [chemical binding]; other site 941968015949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941968015950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941968015951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941968015955 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 941968015956 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941968015957 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941968015962 1 probable transmembrane helix predicted for cbot03193 by TMHMM2.0 at aa 15-37 941968015964 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 941968015965 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 941968015966 NAD(P) binding site [chemical binding]; other site 941968015967 homodimer interface [polypeptide binding]; other site 941968015968 substrate binding site [chemical binding]; other site 941968015969 active site 941968015974 potential frameshift: common BLAST hit: gi|313247868|ref|YP_004033030.1| transposase 941968015975 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941968015976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 941968015978 1 probable transmembrane helix predicted for cbot03196 by TMHMM2.0 at aa 29-51 941968015980 potential frameshift: common BLAST hit: gi|237796566|ref|YP_002864118.1| putative N-acetylmuramoyl-L-alanine amidase 941968015981 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968015982 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968015983 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968015984 active site 941968015985 metal binding site [ion binding]; metal-binding site 941968015989 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 941968015990 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968015991 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968015992 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968016000 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 941968016001 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968016002 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968016003 active site 941968016004 metal binding site [ion binding]; metal-binding site 941968016011 potential frameshift: common BLAST hit: gi|237796568|ref|YP_002864120.1| putative N-acetylmuramoyl-L-alanine amidase 941968016012 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 941968016013 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 941968016016 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 941968016020 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 941968016021 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 941968016022 active site 941968016023 tetramer interface; other site 941968016026 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968016027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968016028 binding surface 941968016029 TPR motif; other site 941968016035 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 941968016036 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 941968016037 active site 941968016038 substrate binding site [chemical binding]; other site 941968016039 metal binding site [ion binding]; metal-binding site 941968016045 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 941968016046 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 941968016047 5S rRNA interface [nucleotide binding]; other site 941968016048 CTC domain interface [polypeptide binding]; other site 941968016049 L16 interface [polypeptide binding]; other site 941968016051 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941968016052 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 941968016053 homodimer interface [polypeptide binding]; other site 941968016054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968016055 catalytic residue [active] 941968016056 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941968016058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968016059 catalytic residue [active] 941968016060 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941968016064 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 941968016068 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 941968016069 active site 941968016070 substrate binding site [chemical binding]; other site 941968016071 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 941968016072 FMN binding site [chemical binding]; other site 941968016073 putative catalytic residues [active] 941968016076 1 probable transmembrane helix predicted for cbot03210 by TMHMM2.0 at aa 7-29 941968016079 Uncharacterized conserved protein [Function unknown]; Region: COG1683 941968016082 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 941968016083 MutS domain III; Region: MutS_III; pfam05192 941968016084 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 941968016085 Walker A/P-loop; other site 941968016086 ATP binding site [chemical binding]; other site 941968016087 Q-loop/lid; other site 941968016088 ABC transporter signature motif; other site 941968016089 Walker B; other site 941968016090 D-loop; other site 941968016091 H-loop/switch region; other site 941968016092 Smr domain; Region: Smr; pfam01713 941968016099 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941968016100 Peptidase family U32; Region: Peptidase_U32; pfam01136 941968016101 Collagenase; Region: DUF3656; pfam12392 941968016102 Peptidase family U32; Region: Peptidase_U32; cl03113 941968016107 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 941968016109 Cell division protein ZapA; Region: ZapA; pfam05164 941968016113 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 941968016114 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 941968016115 putative tRNA-binding site [nucleotide binding]; other site 941968016116 B3/4 domain; Region: B3_4; pfam03483 941968016117 tRNA synthetase B5 domain; Region: B5; smart00874 941968016118 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 941968016119 dimer interface [polypeptide binding]; other site 941968016120 motif 1; other site 941968016121 motif 3; other site 941968016122 motif 2; other site 941968016123 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 941968016131 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 941968016132 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 941968016133 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 941968016134 dimer interface [polypeptide binding]; other site 941968016135 motif 1; other site 941968016136 active site 941968016137 motif 2; other site 941968016138 motif 3; other site 941968016141 1 probable transmembrane helix predicted for cbot03221 by TMHMM2.0 at aa 48-70 941968016142 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941968016143 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 941968016144 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941968016148 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 941968016149 TrkA-N domain; Region: TrkA_N; pfam02254 941968016150 TrkA-C domain; Region: TrkA_C; pfam02080 941968016154 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 941968016155 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 941968016158 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 941968016159 23S rRNA binding site [nucleotide binding]; other site 941968016160 L21 binding site [polypeptide binding]; other site 941968016161 L13 binding site [polypeptide binding]; other site 941968016164 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 941968016167 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 941968016168 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 941968016169 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 941968016172 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 941968016173 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 941968016174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941968016175 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 941968016176 active site 941968016177 dimer interface [polypeptide binding]; other site 941968016178 motif 1; other site 941968016179 motif 2; other site 941968016180 motif 3; other site 941968016181 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 941968016182 anticodon binding site; other site 941968016188 YtxC-like family; Region: YtxC; pfam08812 941968016191 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941968016192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941968016193 Walker A/P-loop; other site 941968016194 ATP binding site [chemical binding]; other site 941968016195 Q-loop/lid; other site 941968016196 ABC transporter signature motif; other site 941968016197 Walker B; other site 941968016198 D-loop; other site 941968016199 H-loop/switch region; other site 941968016203 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 941968016204 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 941968016205 dimerization interface [polypeptide binding]; other site 941968016206 domain crossover interface; other site 941968016207 redox-dependent activation switch; other site 941968016209 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 941968016210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968016211 S-adenosylmethionine binding site [chemical binding]; other site 941968016213 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941968016216 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 941968016217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968016218 Walker A/P-loop; other site 941968016219 ATP binding site [chemical binding]; other site 941968016220 Q-loop/lid; other site 941968016221 ABC transporter signature motif; other site 941968016222 Walker B; other site 941968016223 D-loop; other site 941968016224 H-loop/switch region; other site 941968016225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941968016230 1 probable transmembrane helix predicted for cbot03236 by TMHMM2.0 at aa 7-29 941968016232 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941968016233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941968016234 Walker A/P-loop; other site 941968016235 ATP binding site [chemical binding]; other site 941968016236 Q-loop/lid; other site 941968016237 ABC transporter signature motif; other site 941968016238 Walker B; other site 941968016239 D-loop; other site 941968016240 H-loop/switch region; other site 941968016241 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941968016245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941968016246 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941968016247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968016248 putative PBP binding loops; other site 941968016249 dimer interface [polypeptide binding]; other site 941968016250 ABC-ATPase subunit interface; other site 941968016252 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941968016253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968016254 dimer interface [polypeptide binding]; other site 941968016255 conserved gate region; other site 941968016256 putative PBP binding loops; other site 941968016257 ABC-ATPase subunit interface; other site 941968016261 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941968016262 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941968016263 peptide binding site [polypeptide binding]; other site 941968016269 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 941968016270 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941968016274 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 941968016275 dihydrodipicolinate synthase; Region: dapA; TIGR00674 941968016276 dimer interface [polypeptide binding]; other site 941968016277 active site 941968016278 catalytic residue [active] 941968016283 dihydrodipicolinate reductase; Provisional; Region: PRK00048 941968016284 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 941968016285 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 941968016290 aminotransferase A; Validated; Region: PRK07683 941968016291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941968016292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968016293 homodimer interface [polypeptide binding]; other site 941968016294 catalytic residue [active] 941968016296 1 probable transmembrane helix predicted for cbot03245 by TMHMM2.0 at aa 4-21 941968016297 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 941968016298 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 941968016299 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 941968016300 trimer interface [polypeptide binding]; other site 941968016301 active site 941968016302 substrate binding site [chemical binding]; other site 941968016303 CoA binding site [chemical binding]; other site 941968016307 single-stranded DNA-binding protein; Provisional; Region: PRK05813 941968016308 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941968016309 dimer interface [polypeptide binding]; other site 941968016310 ssDNA binding site [nucleotide binding]; other site 941968016311 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968016314 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 941968016315 NodB motif; other site 941968016316 active site 941968016317 catalytic site [active] 941968016318 metal binding site [ion binding]; metal-binding site 941968016323 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 941968016324 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 941968016325 uncharacterized protein TIGR03905; Region: TIGR03905_4_Cys 941968016326 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 941968016327 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968016328 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941968016332 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 941968016333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941968016334 active site 941968016335 HIGH motif; other site 941968016336 nucleotide binding site [chemical binding]; other site 941968016337 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941968016338 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941968016339 active site 941968016340 KMSKS motif; other site 941968016341 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 941968016342 tRNA binding surface [nucleotide binding]; other site 941968016343 anticodon binding site; other site 941968016344 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 941968016351 putative acetyltransferase YhhY; Provisional; Region: PRK10140 941968016352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968016353 Coenzyme A binding pocket [chemical binding]; other site 941968016356 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 941968016357 active site 941968016358 catalytic triad [active] 941968016360 1 probable transmembrane helix predicted for cbot03256 by TMHMM2.0 at aa 13-35 941968016361 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 941968016362 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 941968016364 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 941968016365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968016366 FeS/SAM binding site; other site 941968016369 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 941968016370 1 probable transmembrane helix predicted for cbot03260 by TMHMM2.0 at aa 7-29 941968016371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968016372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968016373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968016374 Walker A/P-loop; other site 941968016375 ATP binding site [chemical binding]; other site 941968016376 Q-loop/lid; other site 941968016377 ABC transporter signature motif; other site 941968016378 Walker B; other site 941968016379 D-loop; other site 941968016380 H-loop/switch region; other site 941968016390 1 probable transmembrane helix predicted for cbot03262 by TMHMM2.0 at aa 10-32 941968016391 NMT1-like family; Region: NMT1_2; pfam13379 941968016392 NMT1/THI5 like; Region: NMT1; pfam09084 941968016395 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968016396 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 941968016397 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968016398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 941968016399 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968016400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 941968016407 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941968016408 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941968016409 Walker A/P-loop; other site 941968016410 ATP binding site [chemical binding]; other site 941968016411 Q-loop/lid; other site 941968016412 ABC transporter signature motif; other site 941968016413 Walker B; other site 941968016414 D-loop; other site 941968016415 H-loop/switch region; other site 941968016418 1 probable transmembrane helix predicted for cbot03267 by TMHMM2.0 at aa 61-83 941968016419 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941968016420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968016421 dimer interface [polypeptide binding]; other site 941968016422 conserved gate region; other site 941968016423 putative PBP binding loops; other site 941968016424 ABC-ATPase subunit interface; other site 941968016426 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968016427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968016428 binding surface 941968016429 TPR motif; other site 941968016430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968016436 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 941968016437 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 941968016440 recombination regulator RecX; Provisional; Region: recX; PRK14134 941968016443 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941968016444 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941968016445 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941968016448 1 probable transmembrane helix predicted for cbot03272 by TMHMM2.0 at aa 13-35 941968016449 QueT transporter; Region: QueT; pfam06177 941968016453 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 941968016456 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941968016457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941968016458 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941968016462 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941968016465 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 941968016468 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 941968016469 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 941968016472 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 941968016473 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 941968016474 dimer interface [polypeptide binding]; other site 941968016475 active site 941968016476 glycine loop; other site 941968016482 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 941968016483 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968016485 1 probable transmembrane helix predicted for cbot03280 by TMHMM2.0 at aa 10-27 941968016488 sequence-specific DNA binding site [nucleotide binding]; other site 941968016489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 941968016490 salt bridge; other site 941968016491 Cupin domain; Region: Cupin_2; pfam07883 941968016495 1 probable transmembrane helix predicted for cbot03281 by TMHMM2.0 at aa 38-60 941968016496 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 941968016497 Dimer interface [polypeptide binding]; other site 941968016498 BRCT sequence motif; other site 941968016501 1 probable transmembrane helix predicted for cbot03282 by TMHMM2.0 at aa 10-32 941968016502 agmatine deiminase; Region: agmatine_aguA; TIGR03380 941968016503 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 941968016504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 941968016505 metal ion-dependent adhesion site (MIDAS); other site 941968016509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968016510 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941968016511 Walker A motif; other site 941968016512 ATP binding site [chemical binding]; other site 941968016513 Walker B motif; other site 941968016514 arginine finger; other site 941968016518 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 941968016519 Uncharacterized conserved protein [Function unknown]; Region: COG1915 941968016520 Uncharacterized conserved protein [Function unknown]; Region: COG1915 941968016521 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 941968016522 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 941968016523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 941968016525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 941968016527 1 probable transmembrane helix predicted for cbot03291 by TMHMM2.0 at aa 29-51 941968016528 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 941968016529 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968016532 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941968016533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968016534 Walker A motif; other site 941968016535 ATP binding site [chemical binding]; other site 941968016536 Walker B motif; other site 941968016537 arginine finger; other site 941968016538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941968016543 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941968016544 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941968016545 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941968016549 1 probable transmembrane helix predicted for cbot03294 by TMHMM2.0 at aa 44-66 941968016550 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941968016551 Ligand binding site [chemical binding]; other site 941968016552 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941968016556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941968016557 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 941968016558 FAD binding site [chemical binding]; other site 941968016559 homotetramer interface [polypeptide binding]; other site 941968016560 substrate binding pocket [chemical binding]; other site 941968016561 catalytic base [active] 941968016566 putative acyltransferase; Provisional; Region: PRK05790 941968016567 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941968016568 dimer interface [polypeptide binding]; other site 941968016569 active site 941968016574 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 941968016575 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941968016576 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941968016580 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 941968016581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941968016582 substrate binding site [chemical binding]; other site 941968016583 oxyanion hole (OAH) forming residues; other site 941968016584 trimer interface [polypeptide binding]; other site 941968016586 1 probable transmembrane helix predicted for cbot03299 by TMHMM2.0 at aa 24-41 941968016588 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941968016589 GIY-YIG motif/motif A; other site 941968016590 active site 941968016591 catalytic site [active] 941968016592 putative DNA binding site [nucleotide binding]; other site 941968016593 metal binding site [ion binding]; metal-binding site 941968016596 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941968016598 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 941968016599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968016600 Zn2+ binding site [ion binding]; other site 941968016601 Mg2+ binding site [ion binding]; other site 941968016604 1 probable transmembrane helix predicted for cbot03303 by TMHMM2.0 at aa 13-35 941968016606 1 probable transmembrane helix predicted for cbot03304 by TMHMM2.0 at aa 26-48 941968016609 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 941968016612 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 941968016613 homotetramer interface [polypeptide binding]; other site 941968016614 active site 941968016615 metal binding site [ion binding]; metal-binding site 941968016617 1 probable transmembrane helix predicted for cbot03306 by TMHMM2.0 at aa 19-41 941968016619 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 941968016620 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941968016621 active site 941968016622 catalytic site [active] 941968016623 metal binding site [ion binding]; metal-binding site 941968016624 dimer interface [polypeptide binding]; other site 941968016626 1 probable transmembrane helix predicted for cbot03307 by TMHMM2.0 at aa 20-42 941968016627 Cache domain; Region: Cache_1; pfam02743 941968016628 HAMP domain; Region: HAMP; pfam00672 941968016629 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968016630 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968016631 dimer interface [polypeptide binding]; other site 941968016632 putative CheW interface [polypeptide binding]; other site 941968016638 Rubredoxin [Energy production and conversion]; Region: COG1773 941968016639 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 941968016640 iron binding site [ion binding]; other site 941968016641 Rubrerythrin [Energy production and conversion]; Region: COG1592 941968016642 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 941968016643 diiron binding motif [ion binding]; other site 941968016647 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 941968016648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968016649 FeS/SAM binding site; other site 941968016652 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 941968016653 Pyruvate formate lyase 1; Region: PFL1; cd01678 941968016654 coenzyme A binding site [chemical binding]; other site 941968016655 active site 941968016656 catalytic residues [active] 941968016657 glycine loop; other site 941968016665 1 probable transmembrane helix predicted for cbot03312 by TMHMM2.0 at aa 5-27 941968016666 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 941968016667 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 941968016668 5S rRNA interface [nucleotide binding]; other site 941968016669 CTC domain interface [polypeptide binding]; other site 941968016670 L16 interface [polypeptide binding]; other site 941968016672 1 probable transmembrane helix predicted for cbot03313 by TMHMM2.0 at aa 7-29 941968016673 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941968016674 metal binding site 2 [ion binding]; metal-binding site 941968016675 putative DNA binding helix; other site 941968016676 metal binding site 1 [ion binding]; metal-binding site 941968016677 dimer interface [polypeptide binding]; other site 941968016678 structural Zn2+ binding site [ion binding]; other site 941968016680 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941968016681 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941968016685 Predicted transcriptional regulator [Transcription]; Region: COG2378 941968016686 HTH domain; Region: HTH_11; pfam08279 941968016687 WYL domain; Region: WYL; pfam13280 941968016693 CAAX protease self-immunity; Region: Abi; pfam02517 941968016695 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 941968016696 G1 box; other site 941968016697 GTP/Mg2+ binding site [chemical binding]; other site 941968016698 Switch I region; other site 941968016699 G2 box; other site 941968016700 G3 box; other site 941968016701 Switch II region; other site 941968016702 G4 box; other site 941968016703 G5 box; other site 941968016706 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 941968016707 Found in ATP-dependent protease La (LON); Region: LON; smart00464 941968016708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968016709 Walker A motif; other site 941968016710 ATP binding site [chemical binding]; other site 941968016711 Walker B motif; other site 941968016712 arginine finger; other site 941968016713 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941968016720 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 941968016721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968016722 Walker A motif; other site 941968016723 ATP binding site [chemical binding]; other site 941968016724 Walker B motif; other site 941968016725 arginine finger; other site 941968016726 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941968016731 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 941968016732 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 941968016733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968016734 Walker A motif; other site 941968016735 ATP binding site [chemical binding]; other site 941968016736 Walker B motif; other site 941968016737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941968016744 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 941968016745 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 941968016746 oligomer interface [polypeptide binding]; other site 941968016747 active site residues [active] 941968016749 trigger factor; Provisional; Region: tig; PRK01490 941968016750 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941968016751 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 941968016758 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 941968016759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941968016760 DNA interaction; other site 941968016761 Metal-binding active site; metal-binding site 941968016763 1 probable transmembrane helix predicted for cbot03329 by TMHMM2.0 at aa 10-32 941968016765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968016766 active site 941968016769 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 941968016770 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 941968016771 heterodimer interface [polypeptide binding]; other site 941968016772 active site 941968016773 FMN binding site [chemical binding]; other site 941968016774 homodimer interface [polypeptide binding]; other site 941968016775 substrate binding site [chemical binding]; other site 941968016777 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 941968016778 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 941968016779 FAD binding pocket [chemical binding]; other site 941968016780 FAD binding motif [chemical binding]; other site 941968016781 phosphate binding motif [ion binding]; other site 941968016782 beta-alpha-beta structure motif; other site 941968016783 NAD binding pocket [chemical binding]; other site 941968016784 Iron coordination center [ion binding]; other site 941968016788 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 941968016789 active site 941968016790 dimer interface [polypeptide binding]; other site 941968016793 dihydroorotase; Validated; Region: pyrC; PRK09357 941968016794 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968016795 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 941968016796 active site 941968016798 1 probable transmembrane helix predicted for cbot03335 by TMHMM2.0 at aa 26-48 941968016799 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 941968016800 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 941968016801 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 941968016804 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 941968016805 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941968016806 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941968016809 1 probable transmembrane helix predicted for cbot03337 by TMHMM2.0 at aa 15-37 941968016810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968016811 nucleotide binding site [chemical binding]; other site 941968016813 1 probable transmembrane helix predicted for cbot03338 by TMHMM2.0 at aa 10-29 941968016814 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 941968016815 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968016818 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968016820 1 probable transmembrane helix predicted for cbot03340 by TMHMM2.0 at aa 39-61 941968016821 DsrE/DsrF-like family; Region: DrsE; cl00672 941968016824 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941968016825 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941968016826 Walker A/P-loop; other site 941968016827 ATP binding site [chemical binding]; other site 941968016828 Q-loop/lid; other site 941968016829 ABC transporter signature motif; other site 941968016830 Walker B; other site 941968016831 D-loop; other site 941968016832 H-loop/switch region; other site 941968016836 1 probable transmembrane helix predicted for cbot03342 by TMHMM2.0 at aa 20-42 941968016837 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941968016838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941968016839 dimer interface [polypeptide binding]; other site 941968016840 conserved gate region; other site 941968016841 ABC-ATPase subunit interface; other site 941968016844 1 probable transmembrane helix predicted for cbot03346 by TMHMM2.0 at aa 7-24 941968016845 Alkylmercury lyase; Region: MerB; pfam03243 941968016847 1 probable transmembrane helix predicted for cbot03348 by TMHMM2.0 at aa 20-42 941968016848 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 941968016849 NMT1-like family; Region: NMT1_2; pfam13379 941968016852 1 probable transmembrane helix predicted for cbot03350 by TMHMM2.0 at aa 7-24 941968016854 Predicted permeases [General function prediction only]; Region: COG0701 941968016857 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 941968016858 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941968016859 active site 941968016860 metal binding site [ion binding]; metal-binding site 941968016861 homotetramer interface [polypeptide binding]; other site 941968016864 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 941968016865 active site 941968016866 dimerization interface [polypeptide binding]; other site 941968016868 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941968016869 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941968016870 peptide binding site [polypeptide binding]; other site 941968016875 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 941968016876 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 941968016877 GatB domain; Region: GatB_Yqey; smart00845 941968016881 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 941968016882 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 941968016885 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 941968016887 1 probable transmembrane helix predicted for cbot03361 by TMHMM2.0 at aa 25-47 941968016888 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941968016889 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941968016893 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 941968016894 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 941968016895 nucleotide binding pocket [chemical binding]; other site 941968016896 K-X-D-G motif; other site 941968016897 catalytic site [active] 941968016898 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 941968016899 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 941968016900 Helix-hairpin-helix motif; Region: HHH; pfam00633 941968016901 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 941968016902 Dimer interface [polypeptide binding]; other site 941968016915 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 941968016916 Part of AAA domain; Region: AAA_19; pfam13245 941968016917 Family description; Region: UvrD_C_2; pfam13538 941968016919 1 probable transmembrane helix predicted for cbot03365 by TMHMM2.0 at aa 68-90 941968016920 Trp repressor protein; Region: Trp_repressor; cl17266 941968016922 1 probable transmembrane helix predicted for cbot03366 by TMHMM2.0 at aa 7-29 941968016924 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941968016925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968016926 RNA binding surface [nucleotide binding]; other site 941968016927 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 941968016928 active site 941968016929 uracil binding [chemical binding]; other site 941968016931 1 probable transmembrane helix predicted for cbot03367 by TMHMM2.0 at aa 52-74 941968016935 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 941968016936 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941968016937 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941968016938 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941968016939 catalytic residue [active] 941968016941 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 941968016942 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968016943 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968016944 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968016945 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 941968016953 hypothetical protein; Validated; Region: PRK00124 941968016956 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 941968016957 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 941968016958 active site 941968016959 dimer interface [polypeptide binding]; other site 941968016960 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 941968016961 dimer interface [polypeptide binding]; other site 941968016962 active site 941968016967 Probable zinc-binding domain; Region: zf-trcl; pfam13451 941968016968 1 probable transmembrane helix predicted for cbot03373 by TMHMM2.0 at aa 5-27 941968016970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968016971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941968016973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968016974 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941968016975 Coenzyme A binding pocket [chemical binding]; other site 941968016977 D-lactate dehydrogenase; Validated; Region: PRK08605 941968016978 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 941968016979 homodimer interface [polypeptide binding]; other site 941968016980 ligand binding site [chemical binding]; other site 941968016981 NAD binding site [chemical binding]; other site 941968016982 catalytic site [active] 941968016985 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 941968016986 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 941968016987 putative ligand binding site [chemical binding]; other site 941968016988 putative NAD binding site [chemical binding]; other site 941968016989 catalytic site [active] 941968016994 4Fe-4S binding domain; Region: Fer4; pfam00037 941968016995 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941968016996 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941968016997 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941968017005 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941968017006 Ligand binding site [chemical binding]; other site 941968017007 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941968017010 1 probable transmembrane helix predicted for cbot03381 by TMHMM2.0 at aa 33-52 941968017011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941968017012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941968017013 active site 941968017018 1 probable transmembrane helix predicted for cbot03382 by TMHMM2.0 at aa 20-42 941968017020 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 941968017021 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968017023 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 941968017024 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968017027 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 941968017028 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 941968017031 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941968017032 CoA-transferase family III; Region: CoA_transf_3; pfam02515 941968017036 AMP-binding domain protein; Validated; Region: PRK08315 941968017037 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941968017038 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 941968017039 acyl-activating enzyme (AAE) consensus motif; other site 941968017040 putative AMP binding site [chemical binding]; other site 941968017041 putative active site [active] 941968017042 putative CoA binding site [chemical binding]; other site 941968017045 1 probable transmembrane helix predicted for cbot03387 by TMHMM2.0 at aa 10-32 941968017046 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 941968017049 GMP synthase; Reviewed; Region: guaA; PRK00074 941968017050 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 941968017051 AMP/PPi binding site [chemical binding]; other site 941968017052 candidate oxyanion hole; other site 941968017053 catalytic triad [active] 941968017054 potential glutamine specificity residues [chemical binding]; other site 941968017055 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 941968017056 ATP Binding subdomain [chemical binding]; other site 941968017057 Ligand Binding sites [chemical binding]; other site 941968017058 Dimerization subdomain; other site 941968017063 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 941968017064 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941968017065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 941968017066 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 941968017067 active site 941968017075 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 941968017076 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 941968017077 Ligand Binding Site [chemical binding]; other site 941968017079 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 941968017080 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 941968017081 ring oligomerisation interface [polypeptide binding]; other site 941968017082 ATP/Mg binding site [chemical binding]; other site 941968017083 stacking interactions; other site 941968017084 hinge regions; other site 941968017089 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 941968017090 oligomerisation interface [polypeptide binding]; other site 941968017091 mobile loop; other site 941968017092 roof hairpin; other site 941968017097 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 941968017098 4Fe-4S binding domain; Region: Fer4; pfam00037 941968017099 4Fe-4S binding domain; Region: Fer4; pfam00037 941968017100 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 941968017107 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 941968017108 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 941968017109 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941968017110 minor groove reading motif; other site 941968017111 helix-hairpin-helix signature motif; other site 941968017112 substrate binding pocket [chemical binding]; other site 941968017113 active site 941968017118 putative oxidoreductase; Provisional; Region: PRK12831 941968017119 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968017120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968017127 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 941968017128 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 941968017129 FAD binding pocket [chemical binding]; other site 941968017130 FAD binding motif [chemical binding]; other site 941968017131 phosphate binding motif [ion binding]; other site 941968017132 beta-alpha-beta structure motif; other site 941968017133 NAD binding pocket [chemical binding]; other site 941968017134 Iron coordination center [ion binding]; other site 941968017139 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 941968017140 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 941968017141 CoA binding domain; Region: CoA_binding; pfam02629 941968017145 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941968017146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968017147 Walker A/P-loop; other site 941968017148 ATP binding site [chemical binding]; other site 941968017149 Q-loop/lid; other site 941968017150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968017151 ABC transporter; Region: ABC_tran_2; pfam12848 941968017152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941968017158 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941968017159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968017160 active site 941968017161 phosphorylation site [posttranslational modification] 941968017162 intermolecular recognition site; other site 941968017163 dimerization interface [polypeptide binding]; other site 941968017164 LytTr DNA-binding domain; Region: LytTR; pfam04397 941968017170 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 941968017171 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 941968017172 Histidine kinase; Region: His_kinase; pfam06580 941968017173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968017174 ATP binding site [chemical binding]; other site 941968017175 Mg2+ binding site [ion binding]; other site 941968017176 G-X-G motif; other site 941968017181 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 941968017182 Carbon starvation protein CstA; Region: CstA; pfam02554 941968017183 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 941968017184 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 941968017187 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 941968017188 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941968017189 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941968017190 Peptidase M16C associated; Region: M16C_assoc; pfam08367 941968017195 1 probable transmembrane helix predicted for cbot03404 by TMHMM2.0 at aa 7-29 941968017197 pyruvate carboxylase; Reviewed; Region: PRK12999 941968017198 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941968017199 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941968017200 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941968017201 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 941968017202 active site 941968017203 catalytic residues [active] 941968017204 metal binding site [ion binding]; metal-binding site 941968017205 homodimer binding site [polypeptide binding]; other site 941968017206 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941968017207 carboxyltransferase (CT) interaction site; other site 941968017208 biotinylation site [posttranslational modification]; other site 941968017216 UGMP family protein; Validated; Region: PRK09604 941968017217 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 941968017218 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941968017222 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 941968017224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968017225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941968017227 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 941968017228 1 probable transmembrane helix predicted for cbot03409 by TMHMM2.0 at aa 15-37 941968017229 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 941968017231 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941968017232 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 941968017233 intersubunit interface [polypeptide binding]; other site 941968017235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968017236 Zn2+ binding site [ion binding]; other site 941968017237 Mg2+ binding site [ion binding]; other site 941968017238 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941968017239 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968017240 Zn2+ binding site [ion binding]; other site 941968017241 Mg2+ binding site [ion binding]; other site 941968017246 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 941968017247 1 probable transmembrane helix predicted for cbot03413 by TMHMM2.0 at aa 4-26 941968017249 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 941968017250 Glycoprotease family; Region: Peptidase_M22; pfam00814 941968017253 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 941968017254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941968017255 Coenzyme A binding pocket [chemical binding]; other site 941968017257 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 941968017258 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 941968017259 active site 941968017260 HIGH motif; other site 941968017261 dimer interface [polypeptide binding]; other site 941968017262 KMSKS motif; other site 941968017263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968017264 RNA binding surface [nucleotide binding]; other site 941968017268 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 941968017269 Divergent AAA domain; Region: AAA_4; pfam04326 941968017271 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 941968017274 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941968017275 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 941968017276 active site 941968017278 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 941968017279 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 941968017280 G1 box; other site 941968017281 putative GEF interaction site [polypeptide binding]; other site 941968017282 GTP/Mg2+ binding site [chemical binding]; other site 941968017283 Switch I region; other site 941968017284 G2 box; other site 941968017285 G3 box; other site 941968017286 Switch II region; other site 941968017287 G4 box; other site 941968017288 G5 box; other site 941968017289 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 941968017295 sugar phosphate phosphatase; Provisional; Region: PRK10513 941968017296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968017297 active site 941968017298 motif I; other site 941968017299 motif II; other site 941968017300 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941968017302 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 941968017303 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 941968017304 active site 941968017305 HIGH motif; other site 941968017306 dimer interface [polypeptide binding]; other site 941968017307 KMSKS motif; other site 941968017309 1 probable transmembrane helix predicted for cbot03424 by TMHMM2.0 at aa 7-29 941968017310 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 941968017311 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 941968017312 non-heme iron binding site [ion binding]; other site 941968017313 dimer interface [polypeptide binding]; other site 941968017314 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 941968017315 non-heme iron binding site [ion binding]; other site 941968017316 dimer interface [polypeptide binding]; other site 941968017320 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 941968017321 active site 941968017322 catalytic triad [active] 941968017324 1 probable transmembrane helix predicted for cbot03428 by TMHMM2.0 at aa 42-64 941968017326 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968017327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968017328 Walker A/P-loop; other site 941968017329 ATP binding site [chemical binding]; other site 941968017330 Q-loop/lid; other site 941968017331 ABC transporter signature motif; other site 941968017332 Walker B; other site 941968017333 D-loop; other site 941968017334 H-loop/switch region; other site 941968017339 CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116 941968017341 CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116 941968017342 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 941968017343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968017344 FeS/SAM binding site; other site 941968017345 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 941968017346 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 941968017348 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941968017349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941968017350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968017351 Walker A/P-loop; other site 941968017352 ATP binding site [chemical binding]; other site 941968017353 Q-loop/lid; other site 941968017354 ABC transporter signature motif; other site 941968017355 Walker B; other site 941968017356 D-loop; other site 941968017357 H-loop/switch region; other site 941968017362 1 probable transmembrane helix predicted for cbot03437 by TMHMM2.0 at aa 21-43 941968017363 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 941968017364 Putative glucoamylase; Region: Glycoamylase; pfam10091 941968017365 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 941968017366 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 941968017367 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 941968017379 diaminopimelate decarboxylase; Region: lysA; TIGR01048 941968017380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 941968017381 active site 941968017382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968017383 substrate binding site [chemical binding]; other site 941968017384 catalytic residues [active] 941968017385 dimer interface [polypeptide binding]; other site 941968017388 aspartate kinase; Reviewed; Region: PRK06635 941968017389 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 941968017390 putative nucleotide binding site [chemical binding]; other site 941968017391 putative catalytic residues [active] 941968017392 putative Mg ion binding site [ion binding]; other site 941968017393 putative aspartate binding site [chemical binding]; other site 941968017394 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 941968017395 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 941968017396 putative allosteric regulatory residue; other site 941968017402 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 941968017403 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 941968017404 active site 941968017405 metal binding site [ion binding]; metal-binding site 941968017407 1 probable transmembrane helix predicted for cbot03441 by TMHMM2.0 at aa 4-26 941968017408 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941968017409 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 941968017411 hypothetical protein; Provisional; Region: PRK06851 941968017412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 941968017413 Walker A motif; other site 941968017414 ATP binding site [chemical binding]; other site 941968017417 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 941968017418 Part of AAA domain; Region: AAA_19; pfam13245 941968017422 FtsH Extracellular; Region: FtsH_ext; pfam06480 941968017423 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 941968017424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968017425 Walker A motif; other site 941968017426 ATP binding site [chemical binding]; other site 941968017427 Walker B motif; other site 941968017428 arginine finger; other site 941968017429 Peptidase family M41; Region: Peptidase_M41; pfam01434 941968017438 dipeptidase PepV; Reviewed; Region: PRK07318 941968017439 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 941968017440 active site 941968017441 metal binding site [ion binding]; metal-binding site 941968017444 prolyl-tRNA synthetase; Provisional; Region: PRK08661 941968017445 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 941968017446 dimer interface [polypeptide binding]; other site 941968017447 motif 1; other site 941968017448 active site 941968017449 motif 2; other site 941968017450 motif 3; other site 941968017451 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 941968017452 anticodon binding site; other site 941968017453 zinc-binding site [ion binding]; other site 941968017460 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 941968017461 GIY-YIG motif/motif A; other site 941968017462 putative active site [active] 941968017463 putative metal binding site [ion binding]; other site 941968017467 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968017468 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941968017470 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968017471 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 941968017472 Walker A/P-loop; other site 941968017473 ATP binding site [chemical binding]; other site 941968017474 Q-loop/lid; other site 941968017475 ABC transporter signature motif; other site 941968017476 Walker B; other site 941968017477 D-loop; other site 941968017478 H-loop/switch region; other site 941968017482 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 941968017483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968017484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941968017485 DNA binding residues [nucleotide binding] 941968017488 putative transporter; Provisional; Region: PRK11660 941968017489 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 941968017490 Sulfate transporter family; Region: Sulfate_transp; pfam00916 941968017491 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 941968017495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968017496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 941968017497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968017498 dimer interface [polypeptide binding]; other site 941968017499 phosphorylation site [posttranslational modification] 941968017500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968017501 ATP binding site [chemical binding]; other site 941968017502 Mg2+ binding site [ion binding]; other site 941968017503 G-X-G motif; other site 941968017508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968017509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968017510 active site 941968017511 phosphorylation site [posttranslational modification] 941968017512 intermolecular recognition site; other site 941968017513 dimerization interface [polypeptide binding]; other site 941968017514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968017515 DNA binding site [nucleotide binding] 941968017521 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941968017522 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 941968017524 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941968017525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968017526 Walker A/P-loop; other site 941968017527 ATP binding site [chemical binding]; other site 941968017528 Q-loop/lid; other site 941968017529 ABC transporter signature motif; other site 941968017530 Walker B; other site 941968017531 D-loop; other site 941968017532 H-loop/switch region; other site 941968017536 Uncharacterized conserved protein [Function unknown]; Region: COG3589 941968017537 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 941968017541 1 probable transmembrane helix predicted for cbot03460 by TMHMM2.0 at aa 12-34 941968017542 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 941968017544 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 941968017545 methionine cluster; other site 941968017546 active site 941968017547 phosphorylation site [posttranslational modification] 941968017548 metal binding site [ion binding]; metal-binding site 941968017550 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 941968017551 active site 941968017552 P-loop; other site 941968017553 phosphorylation site [posttranslational modification] 941968017555 1 probable transmembrane helix predicted for cbot03463 by TMHMM2.0 at aa 20-42 941968017558 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941968017559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968017560 Walker A motif; other site 941968017561 ATP binding site [chemical binding]; other site 941968017562 Walker B motif; other site 941968017563 arginine finger; other site 941968017564 Transcriptional antiterminator [Transcription]; Region: COG3933 941968017565 PRD domain; Region: PRD; pfam00874 941968017566 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 941968017567 active pocket/dimerization site; other site 941968017568 active site 941968017569 phosphorylation site [posttranslational modification] 941968017570 PRD domain; Region: PRD; pfam00874 941968017577 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 941968017578 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 941968017582 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 941968017583 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 941968017584 NAD binding site [chemical binding]; other site 941968017585 sugar binding site [chemical binding]; other site 941968017586 divalent metal binding site [ion binding]; other site 941968017587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968017588 dimer interface [polypeptide binding]; other site 941968017593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941968017594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941968017595 metal binding site [ion binding]; metal-binding site 941968017596 active site 941968017597 I-site; other site 941968017600 Phage integrase family; Region: Phage_integrase; pfam00589 941968017601 active site 941968017602 DNA binding site [nucleotide binding] 941968017603 Int/Topo IB signature motif; other site 941968017605 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 941968017607 Protein of unknown function DUF43; Region: DUF43; pfam01861 941968017610 Mor transcription activator family; Region: Mor; cl02360 941968017612 1 probable transmembrane helix predicted for cbot03471 by TMHMM2.0 at aa 32-54 941968017613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968017614 NmrA-like family; Region: NmrA; pfam05368 941968017615 NAD(P) binding site [chemical binding]; other site 941968017616 active site 941968017618 1 probable transmembrane helix predicted for cbot03472 by TMHMM2.0 at aa 16-35 941968017620 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 941968017621 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941968017622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968017623 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 941968017624 putative dimerization interface [polypeptide binding]; other site 941968017627 1 probable transmembrane helix predicted for cbot03474 by TMHMM2.0 at aa 12-34 941968017628 Chromate transporter; Region: Chromate_transp; pfam02417 941968017631 Chromate transporter; Region: Chromate_transp; pfam02417 941968017634 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 941968017635 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 941968017636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941968017637 S-adenosylmethionine binding site [chemical binding]; other site 941968017642 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 941968017643 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 941968017646 1 probable transmembrane helix predicted for cbot03478 by TMHMM2.0 at aa 7-29 941968017647 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 941968017648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941968017649 active site 941968017650 catalytic tetrad [active] 941968017651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968017653 1 probable transmembrane helix predicted for cbot03480 by TMHMM2.0 at aa 61-78 941968017654 pyruvate kinase; Provisional; Region: PRK06354 941968017655 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 941968017656 domain interfaces; other site 941968017657 active site 941968017658 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 941968017663 6-phosphofructokinase; Provisional; Region: PRK03202 941968017664 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 941968017665 active site 941968017666 ADP/pyrophosphate binding site [chemical binding]; other site 941968017667 dimerization interface [polypeptide binding]; other site 941968017668 allosteric effector site; other site 941968017669 fructose-1,6-bisphosphate binding site; other site 941968017671 1 probable transmembrane helix predicted for cbot03482 by TMHMM2.0 at aa 13-35 941968017672 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 941968017673 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 941968017674 active site 941968017675 PHP Thumb interface [polypeptide binding]; other site 941968017676 metal binding site [ion binding]; metal-binding site 941968017677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941968017678 generic binding surface II; other site 941968017679 generic binding surface I; other site 941968017686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 941968017687 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 941968017690 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 941968017691 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 941968017692 phosphate binding site [ion binding]; other site 941968017693 putative substrate binding pocket [chemical binding]; other site 941968017694 dimer interface [polypeptide binding]; other site 941968017697 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 941968017699 1 probable transmembrane helix predicted for cbot03486 by TMHMM2.0 at aa 5-27 941968017701 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 941968017702 FAD binding domain; Region: FAD_binding_4; pfam01565 941968017703 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 941968017706 1 probable transmembrane helix predicted for cbot03487 by TMHMM2.0 at aa 36-58 941968017707 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 941968017708 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 941968017709 active site 941968017713 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 941968017714 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941968017715 GIY-YIG motif/motif A; other site 941968017716 active site 941968017717 catalytic site [active] 941968017718 putative DNA binding site [nucleotide binding]; other site 941968017719 metal binding site [ion binding]; metal-binding site 941968017720 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 941968017726 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 941968017728 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 941968017729 generic binding surface II; other site 941968017730 generic binding surface I; other site 941968017731 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941968017732 Zn2+ binding site [ion binding]; other site 941968017733 Mg2+ binding site [ion binding]; other site 941968017736 1 probable transmembrane helix predicted for cbot03491 by TMHMM2.0 at aa 7-29 941968017738 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941968017739 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941968017740 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941968017745 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 941968017747 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 941968017748 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 941968017749 phosphopeptide binding site; other site 941968017752 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 941968017753 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941968017754 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941968017755 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 941968017760 excinuclease ABC subunit B; Provisional; Region: PRK05298 941968017761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968017762 ATP binding site [chemical binding]; other site 941968017763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968017764 nucleotide binding region [chemical binding]; other site 941968017765 ATP-binding site [chemical binding]; other site 941968017766 Ultra-violet resistance protein B; Region: UvrB; pfam12344 941968017767 UvrB/uvrC motif; Region: UVR; pfam02151 941968017777 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 941968017778 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941968017781 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941968017782 C-terminal peptidase (prc); Region: prc; TIGR00225 941968017783 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941968017784 protein binding site [polypeptide binding]; other site 941968017785 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941968017786 Catalytic dyad [active] 941968017792 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 941968017793 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 941968017796 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 941968017797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941968017798 Walker A/P-loop; other site 941968017799 ATP binding site [chemical binding]; other site 941968017800 Q-loop/lid; other site 941968017801 ABC transporter signature motif; other site 941968017802 Walker B; other site 941968017803 D-loop; other site 941968017804 H-loop/switch region; other site 941968017807 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941968017808 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941968017809 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941968017815 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 941968017816 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941968017817 PYR/PP interface [polypeptide binding]; other site 941968017818 dimer interface [polypeptide binding]; other site 941968017819 TPP binding site [chemical binding]; other site 941968017820 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941968017826 transketolase; Reviewed; Region: PRK05899 941968017827 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 941968017828 TPP-binding site [chemical binding]; other site 941968017829 dimer interface [polypeptide binding]; other site 941968017832 PemK-like protein; Region: PemK; pfam02452 941968017834 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 941968017835 alanine racemase; Reviewed; Region: alr; PRK00053 941968017836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 941968017837 active site 941968017838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941968017839 dimer interface [polypeptide binding]; other site 941968017840 substrate binding site [chemical binding]; other site 941968017841 catalytic residues [active] 941968017845 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 941968017848 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 941968017849 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 941968017850 putative substrate binding site [chemical binding]; other site 941968017851 putative ATP binding site [chemical binding]; other site 941968017854 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 941968017856 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 941968017857 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 941968017861 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 941968017863 1 probable transmembrane helix predicted for cbot03514 by TMHMM2.0 at aa 36-58 941968017864 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 941968017865 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 941968017866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968017867 RNA binding surface [nucleotide binding]; other site 941968017871 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941968017872 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941968017875 1 probable transmembrane helix predicted for cbot03516 by TMHMM2.0 at aa 20-42 941968017876 potential frameshift: common BLAST hit: gi|170754346|ref|YP_001783045.1| PAP2 family protein 941968017877 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 941968017878 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941968017880 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 941968017881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968017882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968017883 active site 941968017884 phosphorylation site [posttranslational modification] 941968017885 intermolecular recognition site; other site 941968017886 dimerization interface [polypeptide binding]; other site 941968017887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968017888 DNA binding site [nucleotide binding] 941968017892 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 941968017893 dinuclear metal binding motif [ion binding]; other site 941968017895 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 941968017896 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 941968017897 glutaminase active site [active] 941968017898 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941968017899 dimer interface [polypeptide binding]; other site 941968017900 active site 941968017901 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941968017902 dimer interface [polypeptide binding]; other site 941968017903 active site 941968017911 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 941968017912 active site 941968017913 intersubunit interactions; other site 941968017914 catalytic residue [active] 941968017916 1 probable transmembrane helix predicted for cbot03522 by TMHMM2.0 at aa 7-29 941968017918 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 941968017919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968017920 motif II; other site 941968017922 1 probable transmembrane helix predicted for cbot03523 by TMHMM2.0 at aa 20-42 941968017923 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 941968017924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941968017925 NAD(P) binding site [chemical binding]; other site 941968017926 active site 941968017929 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 941968017931 1 probable transmembrane helix predicted for cbot03525 by TMHMM2.0 at aa 10-32 941968017932 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 941968017933 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 941968017934 Nucleoside recognition; Region: Gate; pfam07670 941968017935 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 941968017939 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 941968017944 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 941968017946 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941968017947 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 941968017948 putative NAD(P) binding site [chemical binding]; other site 941968017949 catalytic Zn binding site [ion binding]; other site 941968017954 1 probable transmembrane helix predicted for cbot03529 by TMHMM2.0 at aa 20-42 941968017955 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941968017956 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941968017957 non-specific DNA interactions [nucleotide binding]; other site 941968017958 DNA binding site [nucleotide binding] 941968017959 sequence specific DNA binding site [nucleotide binding]; other site 941968017960 putative cAMP binding site [chemical binding]; other site 941968017961 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941968017966 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 941968017967 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 941968017968 active site 941968017969 substrate binding site [chemical binding]; other site 941968017970 metal binding site [ion binding]; metal-binding site 941968017976 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 941968017981 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 941968017982 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 941968017983 TPP-binding site [chemical binding]; other site 941968017986 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 941968017987 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 941968017988 dimer interface [polypeptide binding]; other site 941968017989 PYR/PP interface [polypeptide binding]; other site 941968017990 TPP binding site [chemical binding]; other site 941968017991 substrate binding site [chemical binding]; other site 941968017992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941968017996 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 941968017997 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 941968017999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941968018000 P-loop; other site 941968018001 Magnesium ion binding site [ion binding]; other site 941968018003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968018004 nucleotide binding site [chemical binding]; other site 941968018005 Acetokinase family; Region: Acetate_kinase; cl17229 941968018007 phosphate butyryltransferase; Validated; Region: PRK05805 941968018009 butyrate kinase; Provisional; Region: PRK03011 941968018011 1 probable transmembrane helix predicted for cbot03539 by TMHMM2.0 at aa 28-50 941968018012 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 941968018015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 941968018016 YbbR-like protein; Region: YbbR; pfam07949 941968018019 Uncharacterized conserved protein [Function unknown]; Region: COG1624 941968018020 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 941968018022 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941968018025 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 941968018026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941968018030 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941968018031 catalytic residues [active] 941968018033 1 probable transmembrane helix predicted for cbot03545 by TMHMM2.0 at aa 20-42 941968018034 isoaspartyl dipeptidase; Provisional; Region: PRK10657 941968018035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941968018036 active site 941968018039 1 probable transmembrane helix predicted for cbot03546 by TMHMM2.0 at aa 29-51 941968018041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968018042 TPR motif; other site 941968018043 TPR repeat; Region: TPR_11; pfam13414 941968018044 binding surface 941968018051 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 941968018052 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941968018053 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941968018054 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941968018062 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941968018063 dimerization domain swap beta strand [polypeptide binding]; other site 941968018064 regulatory protein interface [polypeptide binding]; other site 941968018065 active site 941968018066 regulatory phosphorylation site [posttranslational modification]; other site 941968018067 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 941968018068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968018069 putative active site [active] 941968018070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941968018071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968018072 Walker A motif; other site 941968018073 ATP binding site [chemical binding]; other site 941968018074 Walker B motif; other site 941968018075 arginine finger; other site 941968018076 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 941968018080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941968018081 TPR motif; other site 941968018082 binding surface 941968018083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 941968018088 fumarate hydratase; Provisional; Region: PRK06842 941968018089 fumarate hydratase; Provisional; Region: PRK06246 941968018091 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941968018092 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941968018093 active site 941968018094 metal binding site [ion binding]; metal-binding site 941968018099 putative transposase OrfB; Reviewed; Region: PHA02517 941968018100 HTH-like domain; Region: HTH_21; pfam13276 941968018101 Integrase core domain; Region: rve; pfam00665 941968018102 Integrase core domain; Region: rve_2; pfam13333 941968018104 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 941968018105 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941968018106 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941968018107 PhoU domain; Region: PhoU; pfam01895 941968018108 PhoU domain; Region: PhoU; pfam01895 941968018115 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 941968018117 1 probable transmembrane helix predicted for cbot03557 by TMHMM2.0 at aa 10-27 941968018118 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 941968018119 23S rRNA interface [nucleotide binding]; other site 941968018120 L3 interface [polypeptide binding]; other site 941968018122 1 probable transmembrane helix predicted for cbot03558 by TMHMM2.0 at aa 10-32 941968018123 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 941968018124 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 941968018125 dimerization interface 3.5A [polypeptide binding]; other site 941968018126 active site 941968018129 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 941968018131 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 941968018132 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941968018133 Walker A/P-loop; other site 941968018134 ATP binding site [chemical binding]; other site 941968018135 Q-loop/lid; other site 941968018136 ABC transporter signature motif; other site 941968018137 Walker B; other site 941968018138 D-loop; other site 941968018139 H-loop/switch region; other site 941968018143 1 probable transmembrane helix predicted for cbot03561 by TMHMM2.0 at aa 20-42 941968018144 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 941968018145 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941968018146 Walker A/P-loop; other site 941968018147 ATP binding site [chemical binding]; other site 941968018148 Q-loop/lid; other site 941968018149 ABC transporter signature motif; other site 941968018150 Walker B; other site 941968018151 D-loop; other site 941968018152 H-loop/switch region; other site 941968018157 1 probable transmembrane helix predicted for cbot03562 by TMHMM2.0 at aa 20-37 941968018161 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 941968018163 1 probable transmembrane helix predicted for cbot03563 by TMHMM2.0 at aa 13-35 941968018165 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 941968018166 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 941968018167 alphaNTD homodimer interface [polypeptide binding]; other site 941968018168 alphaNTD - beta interaction site [polypeptide binding]; other site 941968018169 alphaNTD - beta' interaction site [polypeptide binding]; other site 941968018170 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 941968018175 1 probable transmembrane helix predicted for cbot03564 by TMHMM2.0 at aa 7-29 941968018177 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 941968018178 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 941968018179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968018180 RNA binding surface [nucleotide binding]; other site 941968018185 30S ribosomal protein S11; Validated; Region: PRK05309 941968018188 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 941968018189 30S ribosomal protein S13; Region: bact_S13; TIGR03631 941968018191 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 941968018192 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 941968018193 rRNA binding site [nucleotide binding]; other site 941968018194 predicted 30S ribosome binding site; other site 941968018197 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 941968018198 RNA binding site [nucleotide binding]; other site 941968018199 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941968018200 active site 941968018201 adenylate kinase; Reviewed; Region: adk; PRK00279 941968018202 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 941968018203 AMP-binding site [chemical binding]; other site 941968018204 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 941968018207 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 941968018208 SecY translocase; Region: SecY; pfam00344 941968018212 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 941968018214 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 941968018215 23S rRNA binding site [nucleotide binding]; other site 941968018217 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 941968018218 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 941968018219 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 941968018224 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 941968018225 5S rRNA interface [nucleotide binding]; other site 941968018226 L27 interface [polypeptide binding]; other site 941968018227 23S rRNA interface [nucleotide binding]; other site 941968018228 L5 interface [polypeptide binding]; other site 941968018230 1 probable transmembrane helix predicted for cbot03577 by TMHMM2.0 at aa 21-43 941968018232 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 941968018233 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941968018234 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941968018239 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 941968018241 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 941968018243 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 941968018244 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 941968018245 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 941968018248 1 probable transmembrane helix predicted for cbot03581 by TMHMM2.0 at aa 13-35 941968018249 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 941968018250 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 941968018251 RNA binding site [nucleotide binding]; other site 941968018252 1 probable transmembrane helix predicted for cbot03582 by TMHMM2.0 at aa 34-56 941968018255 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 941968018257 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 941968018259 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 941968018260 23S rRNA interface [nucleotide binding]; other site 941968018261 putative translocon interaction site; other site 941968018262 signal recognition particle (SRP54) interaction site; other site 941968018263 L23 interface [polypeptide binding]; other site 941968018264 trigger factor interaction site; other site 941968018266 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 941968018267 23S rRNA interface [nucleotide binding]; other site 941968018268 5S rRNA interface [nucleotide binding]; other site 941968018269 putative antibiotic binding site [chemical binding]; other site 941968018270 L25 interface [polypeptide binding]; other site 941968018271 L27 interface [polypeptide binding]; other site 941968018275 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 941968018276 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 941968018277 G-X-X-G motif; other site 941968018278 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 941968018283 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 941968018284 putative translocon binding site; other site 941968018285 protein-rRNA interface [nucleotide binding]; other site 941968018287 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 941968018289 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 941968018290 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 941968018291 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 941968018296 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 941968018299 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 941968018301 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 941968018303 1 probable transmembrane helix predicted for cbot03593 by TMHMM2.0 at aa 15-37 941968018305 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 941968018307 elongation factor Tu; Reviewed; Region: PRK00049 941968018308 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941968018309 G1 box; other site 941968018310 GEF interaction site [polypeptide binding]; other site 941968018311 GTP/Mg2+ binding site [chemical binding]; other site 941968018312 Switch I region; other site 941968018313 G2 box; other site 941968018314 G3 box; other site 941968018315 Switch II region; other site 941968018316 G4 box; other site 941968018317 G5 box; other site 941968018318 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941968018319 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941968018320 Antibiotic Binding Site [chemical binding]; other site 941968018327 elongation factor G; Reviewed; Region: PRK00007 941968018328 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 941968018329 G1 box; other site 941968018330 putative GEF interaction site [polypeptide binding]; other site 941968018331 GTP/Mg2+ binding site [chemical binding]; other site 941968018332 Switch I region; other site 941968018333 G2 box; other site 941968018334 G3 box; other site 941968018335 Switch II region; other site 941968018336 G4 box; other site 941968018337 G5 box; other site 941968018338 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941968018339 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 941968018340 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941968018350 30S ribosomal protein S7; Validated; Region: PRK05302 941968018353 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 941968018354 S17 interaction site [polypeptide binding]; other site 941968018355 S8 interaction site; other site 941968018356 16S rRNA interaction site [nucleotide binding]; other site 941968018357 streptomycin interaction site [chemical binding]; other site 941968018358 23S rRNA interaction site [nucleotide binding]; other site 941968018359 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 941968018361 1 probable transmembrane helix predicted for cbot03598 by TMHMM2.0 at aa 7-29 941968018363 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 941968018365 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 941968018366 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 941968018367 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 941968018368 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 941968018369 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 941968018370 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941968018371 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 941968018372 G-loop; other site 941968018373 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 941968018374 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941968018375 DNA binding site [nucleotide binding] 941968018376 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 941968018386 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 941968018387 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 941968018388 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 941968018389 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941968018390 RPB1 interaction site [polypeptide binding]; other site 941968018391 RPB10 interaction site [polypeptide binding]; other site 941968018392 RPB11 interaction site [polypeptide binding]; other site 941968018393 RPB3 interaction site [polypeptide binding]; other site 941968018394 RPB12 interaction site [polypeptide binding]; other site 941968018404 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 941968018405 core dimer interface [polypeptide binding]; other site 941968018406 peripheral dimer interface [polypeptide binding]; other site 941968018407 L10 interface [polypeptide binding]; other site 941968018408 L11 interface [polypeptide binding]; other site 941968018409 putative EF-Tu interaction site [polypeptide binding]; other site 941968018410 putative EF-G interaction site [polypeptide binding]; other site 941968018413 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 941968018414 23S rRNA interface [nucleotide binding]; other site 941968018415 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 941968018417 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 941968018418 mRNA/rRNA interface [nucleotide binding]; other site 941968018421 1 probable transmembrane helix predicted for cbot03604 by TMHMM2.0 at aa 15-37 941968018423 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 941968018424 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 941968018425 23S rRNA interface [nucleotide binding]; other site 941968018426 L7/L12 interface [polypeptide binding]; other site 941968018427 putative thiostrepton binding site; other site 941968018428 L25 interface [polypeptide binding]; other site 941968018433 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 941968018434 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 941968018435 putative homodimer interface [polypeptide binding]; other site 941968018436 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 941968018437 heterodimer interface [polypeptide binding]; other site 941968018438 homodimer interface [polypeptide binding]; other site 941968018445 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 941968018447 1 probable transmembrane helix predicted for cbot03607 by TMHMM2.0 at aa 7-24 941968018448 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 941968018450 1 probable transmembrane helix predicted for cbot03608 by TMHMM2.0 at aa 29-48 941968018451 elongation factor Tu; Reviewed; Region: PRK00049 941968018452 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941968018453 G1 box; other site 941968018454 GEF interaction site [polypeptide binding]; other site 941968018455 GTP/Mg2+ binding site [chemical binding]; other site 941968018456 Switch I region; other site 941968018457 G2 box; other site 941968018458 G3 box; other site 941968018459 Switch II region; other site 941968018460 G4 box; other site 941968018461 G5 box; other site 941968018462 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941968018463 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941968018464 Antibiotic Binding Site [chemical binding]; other site 941968018472 RNA polymerase factor sigma-70; Validated; Region: PRK08295 941968018473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941968018474 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941968018478 YacP-like NYN domain; Region: NYN_YacP; pfam05991 941968018480 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941968018481 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 941968018482 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941968018488 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 941968018491 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 941968018492 dimerization interface [polypeptide binding]; other site 941968018493 active site 941968018494 metal binding site [ion binding]; metal-binding site 941968018497 1 probable transmembrane helix predicted for cbot03614 by TMHMM2.0 at aa 5-27 941968018498 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 941968018499 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941968018500 active site 941968018501 HIGH motif; other site 941968018502 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941968018503 KMSKS motif; other site 941968018504 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 941968018505 tRNA binding surface [nucleotide binding]; other site 941968018506 anticodon binding site; other site 941968018511 1 probable transmembrane helix predicted for cbot03615 by TMHMM2.0 at aa 22-44 941968018514 threonine dehydratase; Provisional; Region: PRK08198 941968018515 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941968018516 tetramer interface [polypeptide binding]; other site 941968018517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941968018518 catalytic residue [active] 941968018519 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 941968018521 prolyl-tRNA synthetase; Provisional; Region: PRK09194 941968018522 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941968018523 motif 1; other site 941968018524 dimer interface [polypeptide binding]; other site 941968018525 active site 941968018526 motif 2; other site 941968018527 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 941968018528 putative deacylase active site [active] 941968018529 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 941968018530 anticodon binding site; other site 941968018531 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 941968018532 putative deacylase active site [active] 941968018533 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 941968018534 anticodon binding site; other site 941968018538 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 941968018539 substrate binding site; other site 941968018540 dimer interface; other site 941968018542 1 probable transmembrane helix predicted for cbot03619 by TMHMM2.0 at aa 13-35 941968018543 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 941968018544 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 941968018545 putative active site [active] 941968018550 1 probable transmembrane helix predicted for cbot03621 by TMHMM2.0 at aa 5-27 941968018551 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 941968018552 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 941968018553 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 941968018557 DNA repair protein RadA; Provisional; Region: PRK11823 941968018558 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 941968018559 Walker A motif/ATP binding site; other site 941968018560 ATP binding site [chemical binding]; other site 941968018561 Walker B motif; other site 941968018562 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941968018566 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 941968018567 Clp amino terminal domain; Region: Clp_N; pfam02861 941968018568 Clp amino terminal domain; Region: Clp_N; pfam02861 941968018569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968018570 Walker A motif; other site 941968018571 ATP binding site [chemical binding]; other site 941968018572 Walker B motif; other site 941968018573 arginine finger; other site 941968018574 UvrB/uvrC motif; Region: UVR; pfam02151 941968018575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968018576 Walker A motif; other site 941968018577 ATP binding site [chemical binding]; other site 941968018578 Walker B motif; other site 941968018579 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941968018592 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 941968018593 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 941968018594 ADP binding site [chemical binding]; other site 941968018595 phosphagen binding site; other site 941968018596 substrate specificity loop; other site 941968018599 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 941968018602 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 941968018605 1 probable transmembrane helix predicted for cbot03628 by TMHMM2.0 at aa 13-35 941968018606 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 941968018607 elongation factor G; Reviewed; Region: PRK12740 941968018608 G1 box; other site 941968018609 putative GEF interaction site [polypeptide binding]; other site 941968018610 GTP/Mg2+ binding site [chemical binding]; other site 941968018611 Switch I region; other site 941968018612 G2 box; other site 941968018613 G3 box; other site 941968018614 Switch II region; other site 941968018615 G4 box; other site 941968018616 G5 box; other site 941968018617 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941968018618 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 941968018619 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941968018627 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 941968018628 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941968018629 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968018630 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 941968018633 glycyl-tRNA synthetase; Provisional; Region: PRK04173 941968018634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941968018635 motif 1; other site 941968018636 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 941968018637 active site 941968018638 motif 2; other site 941968018639 motif 3; other site 941968018640 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 941968018641 anticodon binding site; other site 941968018647 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 941968018648 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 941968018649 dimer interface [polypeptide binding]; other site 941968018650 putative anticodon binding site; other site 941968018651 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 941968018652 motif 1; other site 941968018653 active site 941968018654 motif 2; other site 941968018655 motif 3; other site 941968018660 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 941968018661 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941968018662 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941968018665 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 941968018666 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941968018667 FMN binding site [chemical binding]; other site 941968018668 active site 941968018669 catalytic residues [active] 941968018670 substrate binding site [chemical binding]; other site 941968018674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941968018675 nucleotide binding site [chemical binding]; other site 941968018677 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 941968018678 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 941968018679 Potassium binding sites [ion binding]; other site 941968018680 Cesium cation binding sites [ion binding]; other site 941968018683 FtsH Extracellular; Region: FtsH_ext; pfam06480 941968018684 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 941968018685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968018686 Walker A motif; other site 941968018687 ATP binding site [chemical binding]; other site 941968018688 Walker B motif; other site 941968018689 arginine finger; other site 941968018690 Peptidase family M41; Region: Peptidase_M41; pfam01434 941968018693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968018694 active site 941968018697 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 941968018698 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 941968018699 Ligand Binding Site [chemical binding]; other site 941968018700 TilS substrate C-terminal domain; Region: TilS_C; smart00977 941968018702 stage II sporulation protein E; Region: spore_II_E; TIGR02865 941968018703 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941968018707 hypothetical protein; Provisional; Region: PRK05807 941968018708 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941968018709 RNA binding site [nucleotide binding]; other site 941968018712 Septum formation initiator; Region: DivIC; pfam04977 941968018714 1 probable transmembrane helix predicted for cbot03643 by TMHMM2.0 at aa 9-28 941968018715 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 941968018717 sporulation protein YabP; Region: spore_yabP; TIGR02892 941968018719 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941968018720 RNA binding surface [nucleotide binding]; other site 941968018723 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941968018724 IHF dimer interface [polypeptide binding]; other site 941968018725 IHF - DNA interface [nucleotide binding]; other site 941968018727 1 probable transmembrane helix predicted for cbot03647 by TMHMM2.0 at aa 20-42 941968018729 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 941968018730 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 941968018731 putative SAM binding site [chemical binding]; other site 941968018732 putative homodimer interface [polypeptide binding]; other site 941968018733 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 941968018734 homodimer interface [polypeptide binding]; other site 941968018735 metal binding site [ion binding]; metal-binding site 941968018736 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 941968018737 homodimer interface [polypeptide binding]; other site 941968018738 active site 941968018739 putative chemical substrate binding site [chemical binding]; other site 941968018740 metal binding site [ion binding]; metal-binding site 941968018747 stage V sporulation protein B; Region: spore_V_B; TIGR02900 941968018748 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941968018752 stage V sporulation protein T; Region: spore_V_T; TIGR02851 941968018753 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 941968018755 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 941968018756 SurA N-terminal domain; Region: SurA_N_3; cl07813 941968018757 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941968018763 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 941968018764 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 941968018765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941968018766 ATP binding site [chemical binding]; other site 941968018767 putative Mg++ binding site [ion binding]; other site 941968018768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941968018769 nucleotide binding region [chemical binding]; other site 941968018770 ATP-binding site [chemical binding]; other site 941968018771 TRCF domain; Region: TRCF; pfam03461 941968018782 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 941968018783 putative active site [active] 941968018784 catalytic residue [active] 941968018787 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941968018788 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941968018789 protein binding site [polypeptide binding]; other site 941968018796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941968018797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941968018798 dimerization interface [polypeptide binding]; other site 941968018799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941968018800 dimer interface [polypeptide binding]; other site 941968018801 phosphorylation site [posttranslational modification] 941968018802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941968018803 ATP binding site [chemical binding]; other site 941968018804 Mg2+ binding site [ion binding]; other site 941968018805 G-X-G motif; other site 941968018813 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941968018814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941968018815 active site 941968018816 phosphorylation site [posttranslational modification] 941968018817 intermolecular recognition site; other site 941968018818 dimerization interface [polypeptide binding]; other site 941968018819 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941968018820 DNA binding site [nucleotide binding] 941968018826 1 probable transmembrane helix predicted for cbot03656 by TMHMM2.0 at aa 15-34 941968018827 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 941968018828 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 941968018829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968018830 active site 941968018832 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 941968018833 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 941968018834 Substrate binding site; other site 941968018835 Mg++ binding site; other site 941968018836 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 941968018837 active site 941968018838 substrate binding site [chemical binding]; other site 941968018839 CoA binding site [chemical binding]; other site 941968018844 regulatory protein SpoVG; Reviewed; Region: PRK13259 941968018846 1 probable transmembrane helix predicted for cbot03659 by TMHMM2.0 at aa 26-48 941968018848 pur operon repressor; Provisional; Region: PRK09213 941968018849 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 941968018850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941968018851 active site 941968018853 1 probable transmembrane helix predicted for cbot03660 by TMHMM2.0 at aa 85-104 941968018855 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 941968018856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941968018857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941968018858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941968018860 1 probable transmembrane helix predicted for cbot03661 by TMHMM2.0 at aa 13-32 941968018863 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 941968018864 4Fe-4S binding domain; Region: Fer4; pfam00037 941968018865 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 941968018868 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941968018869 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941968018870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941968018871 motif II; other site 941968018874 1 probable transmembrane helix predicted for cbot03665 by TMHMM2.0 at aa 5-27 941968018875 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 941968018876 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 941968018878 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 941968018879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968018880 FeS/SAM binding site; other site 941968018885 1 probable transmembrane helix predicted for cbot03667 by TMHMM2.0 at aa 5-27 941968018888 Uncharacterized membrane protein [Function unknown]; Region: COG3949 941968018889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968018890 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 941968018891 FeS/SAM binding site; other site 941968018892 1 probable transmembrane helix predicted for cbot03670 by TMHMM2.0 at aa 28-50 941968018894 Heme NO binding; Region: HNOB; pfam07700 941968018895 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941968018896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941968018897 dimer interface [polypeptide binding]; other site 941968018898 putative CheW interface [polypeptide binding]; other site 941968018905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941968018906 non-specific DNA binding site [nucleotide binding]; other site 941968018907 salt bridge; other site 941968018908 sequence-specific DNA binding site [nucleotide binding]; other site 941968018911 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 941968018912 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 941968018913 active site 941968018915 glutamate racemase; Provisional; Region: PRK00865 941968018917 glutamine synthetase, type I; Region: GlnA; TIGR00653 941968018918 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941968018921 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 941968018922 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 941968018923 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941968018924 hinge; other site 941968018925 active site 941968018929 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 941968018933 1 probable transmembrane helix predicted for cbot03679 by TMHMM2.0 at aa 27-49 941968018934 Sporulation and spore germination; Region: Germane; pfam10646 941968018937 hypothetical protein; Provisional; Region: PRK05590 941968018938 SEC-C motif; Region: SEC-C; pfam02810 941968018940 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 941968018942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941968018943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941968018944 putative substrate translocation pore; other site 941968018947 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941968018948 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941968018951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941968018952 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 941968018953 DNA-binding interface [nucleotide binding]; DNA binding site 941968018956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968018957 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941968018958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941968018962 methionine aminopeptidase; Provisional; Region: PRK12318 941968018963 SEC-C motif; Region: SEC-C; pfam02810 941968018964 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941968018965 active site 941968018969 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 941968018970 putative FMN binding site [chemical binding]; other site 941968018972 1 probable transmembrane helix predicted for cbot03689 by TMHMM2.0 at aa 34-56 941968018973 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 941968018975 1 probable transmembrane helix predicted for cbot03690 by TMHMM2.0 at aa 32-49 941968018976 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 941968018977 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941968018980 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 941968018982 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 941968018983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968018984 FeS/SAM binding site; other site 941968018989 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 941968018990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941968018991 FeS/SAM binding site; other site 941968018992 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 941968018998 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 941968018999 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 941968019000 G1 box; other site 941968019001 GTP/Mg2+ binding site [chemical binding]; other site 941968019002 Switch I region; other site 941968019003 G2 box; other site 941968019004 Switch II region; other site 941968019005 G3 box; other site 941968019008 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 941968019009 Na binding site [ion binding]; other site 941968019011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941968019012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941968019014 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 941968019015 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 941968019016 active site 941968019017 PHP-associated; Region: PHP_C; pfam13263 941968019021 dUTPase; Region: dUTPase_2; pfam08761 941968019022 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 941968019023 active site 941968019024 homodimer interface [polypeptide binding]; other site 941968019025 metal binding site [ion binding]; metal-binding site 941968019027 Protein of unknown function, DUF606; Region: DUF606; pfam04657 941968019030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941968019031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968019032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941968019033 dimerization interface [polypeptide binding]; other site 941968019036 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 941968019037 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 941968019038 active site 941968019039 catalytic residues [active] 941968019041 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 941968019042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941968019043 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 941968019044 putative dimerization interface [polypeptide binding]; other site 941968019046 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 941968019047 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 941968019048 putative ligand binding site [chemical binding]; other site 941968019049 NAD binding site [chemical binding]; other site 941968019050 catalytic site [active] 941968019053 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 941968019057 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 941968019058 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 941968019061 biotin carboxylase; Validated; Region: PRK05586 941968019062 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941968019063 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941968019064 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941968019068 1 probable transmembrane helix predicted for cbot03707 by TMHMM2.0 at aa 20-42 941968019071 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 941968019073 1 probable transmembrane helix predicted for cbot03708 by TMHMM2.0 at aa 15-37 941968019076 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 941968019077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941968019078 carboxyltransferase (CT) interaction site; other site 941968019079 biotinylation site [posttranslational modification]; other site 941968019081 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 941968019082 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941968019083 dimer interface [polypeptide binding]; other site 941968019084 active site 941968019089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941968019090 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 941968019091 NAD(P) binding site [chemical binding]; other site 941968019092 homotetramer interface [polypeptide binding]; other site 941968019093 homodimer interface [polypeptide binding]; other site 941968019094 active site 941968019097 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 941968019098 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941968019103 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 941968019104 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941968019105 FMN binding site [chemical binding]; other site 941968019106 substrate binding site [chemical binding]; other site 941968019107 putative catalytic residue [active] 941968019109 1 probable transmembrane helix predicted for cbot03713 by TMHMM2.0 at aa 21-43 941968019112 acyl carrier protein; Provisional; Region: acpP; PRK00982 941968019114 1 probable transmembrane helix predicted for cbot03714 by TMHMM2.0 at aa 4-26 941968019115 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 941968019116 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941968019117 dimer interface [polypeptide binding]; other site 941968019118 active site 941968019119 CoA binding pocket [chemical binding]; other site 941968019123 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941968019124 MarR family; Region: MarR_2; pfam12802 941968019127 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 941968019128 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941968019129 FMN binding site [chemical binding]; other site 941968019130 substrate binding site [chemical binding]; other site 941968019131 putative catalytic residue [active] 941968019133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 941968019134 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941968019135 Peptidase family M23; Region: Peptidase_M23; pfam01551 941968019138 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 941968019139 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 941968019140 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 941968019143 DNA replication protein DnaC; Validated; Region: PRK06835 941968019144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968019145 Walker A motif; other site 941968019146 ATP binding site [chemical binding]; other site 941968019149 PEP synthetase regulatory protein; Provisional; Region: PRK05339 941968019152 CoA binding domain; Region: CoA_binding_2; pfam13380 941968019155 1 probable transmembrane helix predicted for cbot03722 by TMHMM2.0 at aa 15-37 941968019156 flavoprotein, HI0933 family; Region: TIGR00275 941968019158 1 probable transmembrane helix predicted for cbot03723 by TMHMM2.0 at aa 7-29 941968019159 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 941968019160 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941968019161 active site 941968019162 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941968019163 active site 941968019166 putative transposase OrfB; Reviewed; Region: PHA02517 941968019167 HTH-like domain; Region: HTH_21; pfam13276 941968019168 Integrase core domain; Region: rve; pfam00665 941968019169 Integrase core domain; Region: rve_2; pfam13333 941968019170 Winged helix-turn helix; Region: HTH_29; pfam13551 941968019171 Helix-turn-helix domain; Region: HTH_28; pfam13518 941968019172 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 941968019174 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 941968019175 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 941968019176 GDP-binding site [chemical binding]; other site 941968019177 ACT binding site; other site 941968019178 IMP binding site; other site 941968019181 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 941968019182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941968019185 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 941968019187 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 941968019188 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 941968019189 active site 941968019190 substrate binding site [chemical binding]; other site 941968019191 metal binding site [ion binding]; metal-binding site 941968019198 replicative DNA helicase; Provisional; Region: PRK05595 941968019199 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 941968019200 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 941968019201 Walker A motif; other site 941968019202 ATP binding site [chemical binding]; other site 941968019203 Walker B motif; other site 941968019204 DNA binding loops [nucleotide binding] 941968019208 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 941968019209 Src homology 2 (SH2) domain; Region: SH2; cl15255 941968019210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941968019211 Walker A motif; other site 941968019212 ATP binding site [chemical binding]; other site 941968019213 Walker B motif; other site 941968019214 arginine finger; other site 941968019215 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941968019222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 941968019223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 941968019224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 941968019227 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 941968019228 DHH family; Region: DHH; pfam01368 941968019229 DHHA1 domain; Region: DHHA1; pfam02272 941968019233 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 941968019236 MazG-like family; Region: MazG-like; pfam12643 941968019238 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 941968019241 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941968019242 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941968019243 dimer interface [polypeptide binding]; other site 941968019244 ssDNA binding site [nucleotide binding]; other site 941968019245 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941968019247 1 probable transmembrane helix predicted for cbot03737 by TMHMM2.0 at aa 13-35 941968019248 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 941968019250 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 941968019251 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 941968019253 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 941968019255 1 probable transmembrane helix predicted for cbot03740 by TMHMM2.0 at aa 13-35 941968019257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941968019258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941968019260 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 941968019262 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941968019263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941968019264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941968019265 catalytic residue [active] 941968019267 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 941968019269 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 941968019271 1 probable transmembrane helix predicted for cbot03746 by TMHMM2.0 at aa 13-35 941968019272 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 941968019273 ParB-like nuclease domain; Region: ParB; smart00470 941968019278 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 941968019279 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941968019280 P-loop; other site 941968019281 Magnesium ion binding site [ion binding]; other site 941968019282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941968019283 Magnesium ion binding site [ion binding]; other site 941968019285 1 probable transmembrane helix predicted for cbot03749 by TMHMM2.0 at aa 32-54 941968019287 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 941968019288 ParB-like nuclease domain; Region: ParBc; pfam02195 941968019292 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 941968019293 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 941968019294 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 941968019295 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 941968019296 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 941968019297 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 941968019302 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 941968019303 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 941968019304 trmE is a tRNA modification GTPase; Region: trmE; cd04164 941968019305 G1 box; other site 941968019306 GTP/Mg2+ binding site [chemical binding]; other site 941968019307 Switch I region; other site 941968019308 G2 box; other site 941968019309 Switch II region; other site 941968019310 G3 box; other site 941968019311 G4 box; other site 941968019312 G5 box; other site 941968019313 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 941968019318 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 941968019319 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 941968019320 G-X-X-G motif; other site 941968019321 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 941968019322 RxxxH motif; other site 941968019325 1 probable transmembrane helix predicted for cbot03753 by TMHMM2.0 at aa 32-54 941968019326 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 941968019328 Haemolytic domain; Region: Haemolytic; pfam01809 941968019330 ribonuclease P; Reviewed; Region: rnpA; PRK00499 941968019332 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399