-- dump date 20140619_043757 -- class Genbank::misc_feature -- table misc_feature_note -- id note 394503000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 394503000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 394503000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000004 Walker A motif; other site 394503000005 ATP binding site [chemical binding]; other site 394503000006 Walker B motif; other site 394503000007 arginine finger; other site 394503000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 394503000009 DnaA box-binding interface [nucleotide binding]; other site 394503000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 394503000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 394503000012 putative DNA binding surface [nucleotide binding]; other site 394503000013 dimer interface [polypeptide binding]; other site 394503000014 beta-clamp/clamp loader binding surface; other site 394503000015 beta-clamp/translesion DNA polymerase binding surface; other site 394503000016 S4 domain; Region: S4_2; pfam13275 394503000017 recombination protein F; Reviewed; Region: recF; PRK00064 394503000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 394503000019 Walker A/P-loop; other site 394503000020 ATP binding site [chemical binding]; other site 394503000021 Q-loop/lid; other site 394503000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000023 ABC transporter signature motif; other site 394503000024 Walker B; other site 394503000025 D-loop; other site 394503000026 H-loop/switch region; other site 394503000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 394503000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503000029 ATP binding site [chemical binding]; other site 394503000030 Mg2+ binding site [ion binding]; other site 394503000031 G-X-G motif; other site 394503000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 394503000033 anchoring element; other site 394503000034 dimer interface [polypeptide binding]; other site 394503000035 ATP binding site [chemical binding]; other site 394503000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 394503000037 active site 394503000038 putative metal-binding site [ion binding]; other site 394503000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 394503000040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 394503000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 394503000042 P-loop; other site 394503000043 Magnesium ion binding site [ion binding]; other site 394503000044 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 394503000045 ParB-like nuclease domain; Region: ParB; smart00470 394503000046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 394503000047 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 394503000048 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 394503000049 pyrophosphatase PpaX; Provisional; Region: PRK13288 394503000050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503000051 active site 394503000052 motif I; other site 394503000053 motif II; other site 394503000054 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 394503000055 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 394503000056 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 394503000057 dimer interface [polypeptide binding]; other site 394503000058 PYR/PP interface [polypeptide binding]; other site 394503000059 TPP binding site [chemical binding]; other site 394503000060 substrate binding site [chemical binding]; other site 394503000061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 394503000062 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 394503000063 Domain of unknown function; Region: EKR; pfam10371 394503000064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503000065 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 394503000066 TPP-binding site [chemical binding]; other site 394503000067 dimer interface [polypeptide binding]; other site 394503000068 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 394503000069 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 394503000070 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 394503000071 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 394503000072 Potassium binding sites [ion binding]; other site 394503000073 Cesium cation binding sites [ion binding]; other site 394503000074 YabG peptidase U57; Region: Peptidase_U57; cl05250 394503000075 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 394503000076 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 394503000077 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 394503000078 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 394503000079 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 394503000080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 394503000081 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 394503000082 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 394503000083 Transcriptional regulators [Transcription]; Region: FadR; COG2186 394503000084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503000085 DNA-binding site [nucleotide binding]; DNA binding site 394503000086 FCD domain; Region: FCD; pfam07729 394503000087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000088 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 394503000089 Walker A motif; other site 394503000090 ATP binding site [chemical binding]; other site 394503000091 Walker B motif; other site 394503000092 arginine finger; other site 394503000093 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 394503000094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503000095 Coenzyme A binding pocket [chemical binding]; other site 394503000096 Protein of unknown function (DUF342); Region: DUF342; pfam03961 394503000097 GAF domain; Region: GAF_3; pfam13492 394503000098 GAF domain; Region: GAF_3; pfam13492 394503000099 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 394503000100 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 394503000101 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503000102 active site 394503000103 metal binding site [ion binding]; metal-binding site 394503000104 DNA binding site [nucleotide binding] 394503000105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000106 AAA domain; Region: AAA_23; pfam13476 394503000107 Walker A/P-loop; other site 394503000108 ATP binding site [chemical binding]; other site 394503000109 ABC transporter signature motif; other site 394503000110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000111 ABC transporter signature motif; other site 394503000112 Walker B; other site 394503000113 D-loop; other site 394503000114 H-loop/switch region; other site 394503000115 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503000116 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 394503000117 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 394503000118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 394503000119 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 394503000120 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503000121 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 394503000122 germination protein YpeB; Region: spore_YpeB; TIGR02889 394503000123 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 394503000124 MarR family; Region: MarR_2; pfam12802 394503000125 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 394503000126 active site 394503000127 catalytic residues [active] 394503000128 metal binding site [ion binding]; metal-binding site 394503000129 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 394503000130 S-layer homology domain; Region: SLH; pfam00395 394503000131 S-layer homology domain; Region: SLH; pfam00395 394503000132 S-layer homology domain; Region: SLH; pfam00395 394503000133 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 394503000134 CAAX protease self-immunity; Region: Abi; pfam02517 394503000135 DNA replication protein DnaC; Validated; Region: PRK06835 394503000136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000137 Walker A motif; other site 394503000138 ATP binding site [chemical binding]; other site 394503000139 Walker B motif; other site 394503000140 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 394503000141 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 394503000142 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 394503000143 Ferritin-like domain; Region: Ferritin; pfam00210 394503000144 ferroxidase diiron center [ion binding]; other site 394503000145 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 394503000146 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 394503000147 peptide binding site [polypeptide binding]; other site 394503000148 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 394503000149 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 394503000150 Walker A/P-loop; other site 394503000151 ATP binding site [chemical binding]; other site 394503000152 Q-loop/lid; other site 394503000153 ABC transporter signature motif; other site 394503000154 Walker B; other site 394503000155 D-loop; other site 394503000156 H-loop/switch region; other site 394503000157 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 394503000158 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 394503000159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 394503000160 Walker A/P-loop; other site 394503000161 ATP binding site [chemical binding]; other site 394503000162 Q-loop/lid; other site 394503000163 ABC transporter signature motif; other site 394503000164 Walker B; other site 394503000165 D-loop; other site 394503000166 H-loop/switch region; other site 394503000167 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 394503000168 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 394503000169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 394503000170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000171 dimer interface [polypeptide binding]; other site 394503000172 conserved gate region; other site 394503000173 putative PBP binding loops; other site 394503000174 ABC-ATPase subunit interface; other site 394503000175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 394503000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000177 dimer interface [polypeptide binding]; other site 394503000178 conserved gate region; other site 394503000179 putative PBP binding loops; other site 394503000180 ABC-ATPase subunit interface; other site 394503000181 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 394503000182 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 394503000183 HAMP domain; Region: HAMP; pfam00672 394503000184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503000185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503000186 dimer interface [polypeptide binding]; other site 394503000187 putative CheW interface [polypeptide binding]; other site 394503000188 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 394503000189 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 394503000190 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 394503000191 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 394503000192 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 394503000193 active site 394503000194 metal binding site [ion binding]; metal-binding site 394503000195 DNA binding site [nucleotide binding] 394503000196 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 394503000197 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 394503000198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000199 Walker A/P-loop; other site 394503000200 ATP binding site [chemical binding]; other site 394503000201 Q-loop/lid; other site 394503000202 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 394503000203 ABC transporter signature motif; other site 394503000204 Walker B; other site 394503000205 D-loop; other site 394503000206 H-loop/switch region; other site 394503000207 glycogen branching enzyme; Provisional; Region: PRK05402 394503000208 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 394503000209 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 394503000210 active site 394503000211 catalytic site [active] 394503000212 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 394503000213 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 394503000214 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 394503000215 putative ligand binding site [chemical binding]; other site 394503000216 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 394503000217 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 394503000218 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 394503000219 dimer interface [polypeptide binding]; other site 394503000220 ssDNA binding site [nucleotide binding]; other site 394503000221 tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503000222 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 394503000223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503000224 non-specific DNA binding site [nucleotide binding]; other site 394503000225 salt bridge; other site 394503000226 sequence-specific DNA binding site [nucleotide binding]; other site 394503000227 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503000228 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 394503000229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 394503000230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000231 AAA domain; Region: AAA_23; pfam13476 394503000232 Walker A/P-loop; other site 394503000233 ATP binding site [chemical binding]; other site 394503000234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503000235 ATP binding site [chemical binding]; other site 394503000236 putative Mg++ binding site [ion binding]; other site 394503000237 nucleotide binding region [chemical binding]; other site 394503000238 helicase superfamily c-terminal domain; Region: HELICc; smart00490 394503000239 ATP-binding site [chemical binding]; other site 394503000240 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 394503000241 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 394503000242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 394503000243 active site 394503000244 DNA binding site [nucleotide binding] 394503000245 Int/Topo IB signature motif; other site 394503000246 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 394503000247 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 394503000248 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 394503000249 active site 394503000250 DNA binding site [nucleotide binding] 394503000251 Int/Topo IB signature motif; other site 394503000252 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 394503000253 active site 394503000254 catalytic residues [active] 394503000255 DNA binding site [nucleotide binding] 394503000256 Int/Topo IB signature motif; other site 394503000257 SIR2-like domain; Region: SIR2_2; pfam13289 394503000258 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 394503000259 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 394503000260 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 394503000261 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 394503000262 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 394503000263 Prephenate dehydratase; Region: PDT; pfam00800 394503000264 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 394503000265 putative L-Phe binding site [chemical binding]; other site 394503000266 MazG-like family; Region: MazG-like; pfam12643 394503000267 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 394503000268 cyclase homology domain; Region: CHD; cd07302 394503000269 nucleotidyl binding site; other site 394503000270 dimer interface [polypeptide binding]; other site 394503000271 metal binding site [ion binding]; metal-binding site 394503000272 DHH family; Region: DHH; pfam01368 394503000273 DHHA1 domain; Region: DHHA1; pfam02272 394503000274 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 394503000275 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 394503000276 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 394503000277 replicative DNA helicase; Region: DnaB; TIGR00665 394503000278 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 394503000279 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 394503000280 Walker A motif; other site 394503000281 ATP binding site [chemical binding]; other site 394503000282 Walker B motif; other site 394503000283 DNA binding loops [nucleotide binding] 394503000284 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 394503000285 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 394503000286 Ligand Binding Site [chemical binding]; other site 394503000287 TilS substrate C-terminal domain; Region: TilS_C; smart00977 394503000288 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503000289 active site 394503000290 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 394503000291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000292 Walker A motif; other site 394503000293 ATP binding site [chemical binding]; other site 394503000294 Walker B motif; other site 394503000295 arginine finger; other site 394503000296 Peptidase family M41; Region: Peptidase_M41; pfam01434 394503000297 Predicted thioesterase [General function prediction only]; Region: COG5496 394503000298 S-adenosylmethionine synthetase; Validated; Region: PRK05250 394503000299 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 394503000300 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 394503000301 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 394503000302 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 394503000303 AAA domain; Region: AAA_30; pfam13604 394503000304 Family description; Region: UvrD_C_2; pfam13538 394503000305 comF family protein; Region: comF; TIGR00201 394503000306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503000307 active site 394503000308 flagellar operon protein TIGR03826; Region: YvyF 394503000309 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 394503000310 FlgN protein; Region: FlgN; pfam05130 394503000311 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 394503000312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 394503000313 metal ion-dependent adhesion site (MIDAS); other site 394503000314 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 394503000315 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 394503000316 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 394503000317 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 394503000318 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 394503000319 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 394503000320 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 394503000321 flagellar assembly protein FliW; Provisional; Region: PRK13285 394503000322 carbon storage regulator; Provisional; Region: PRK01712 394503000323 flagellin; Provisional; Region: PRK12804 394503000324 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 394503000325 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 394503000326 flagellin; Provisional; Region: PRK12804 394503000327 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 394503000328 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 394503000329 flagellin; Provisional; Region: PRK12802 394503000330 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 394503000331 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 394503000332 FlaG protein; Region: FlaG; pfam03646 394503000333 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 394503000334 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 394503000335 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 394503000336 FlgN protein; Region: FlgN; pfam05130 394503000337 Kelch motif; Region: Kelch_1; pfam01344 394503000338 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 394503000339 Kelch domain; Region: Kelch; smart00612 394503000340 Kelch motif; Region: Kelch_1; pfam01344 394503000341 Kelch motif; Region: Kelch_1; pfam01344 394503000342 Kelch motif; Region: Kelch_1; pfam01344 394503000343 Kelch motif; Region: Kelch_1; pfam01344 394503000344 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 394503000345 Radical SAM superfamily; Region: Radical_SAM; pfam04055 394503000346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503000347 FeS/SAM binding site; other site 394503000348 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 394503000349 Catalytic domain of Protein Kinases; Region: PKc; cd00180 394503000350 active site 394503000351 ATP binding site [chemical binding]; other site 394503000352 substrate binding site [chemical binding]; other site 394503000353 activation loop (A-loop); other site 394503000354 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 394503000355 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 394503000356 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 394503000357 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 394503000358 AAA domain; Region: AAA_31; pfam13614 394503000359 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 394503000360 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503000361 Walker A motif; other site 394503000362 ATP binding site [chemical binding]; other site 394503000363 Walker B motif; other site 394503000364 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 394503000365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503000366 FeS/SAM binding site; other site 394503000367 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 394503000368 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 394503000369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503000370 Walker A/P-loop; other site 394503000371 ATP binding site [chemical binding]; other site 394503000372 Q-loop/lid; other site 394503000373 ABC transporter signature motif; other site 394503000374 Walker B; other site 394503000375 D-loop; other site 394503000376 H-loop/switch region; other site 394503000377 ABC transporter; Region: ABC_tran_2; pfam12848 394503000378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503000379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503000380 DEAD-like helicases superfamily; Region: DEXDc; smart00487 394503000381 ATP binding site [chemical binding]; other site 394503000382 putative Mg++ binding site [ion binding]; other site 394503000383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503000384 nucleotide binding region [chemical binding]; other site 394503000385 ATP-binding site [chemical binding]; other site 394503000386 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503000387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503000389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000390 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 394503000391 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 394503000392 substrate binding site [chemical binding]; other site 394503000393 ligand binding site [chemical binding]; other site 394503000394 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 394503000395 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 394503000396 substrate binding site [chemical binding]; other site 394503000397 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 394503000398 tartrate dehydrogenase; Region: TTC; TIGR02089 394503000399 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 394503000400 EamA-like transporter family; Region: EamA; pfam00892 394503000401 EamA-like transporter family; Region: EamA; pfam00892 394503000402 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 394503000403 proposed catalytic triad [active] 394503000404 active site nucleophile [active] 394503000405 cyanophycin synthetase; Provisional; Region: PRK14016 394503000406 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503000407 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503000408 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503000409 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503000410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503000411 putative DNA binding site [nucleotide binding]; other site 394503000412 putative Zn2+ binding site [ion binding]; other site 394503000413 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 394503000414 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 394503000415 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 394503000416 pantothenate kinase; Reviewed; Region: PRK13318 394503000417 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 394503000418 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 394503000419 NAD binding site [chemical binding]; other site 394503000420 dimer interface [polypeptide binding]; other site 394503000421 substrate binding site [chemical binding]; other site 394503000422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503000423 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 394503000424 Malic enzyme, N-terminal domain; Region: malic; pfam00390 394503000425 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 394503000426 putative NAD(P) binding site [chemical binding]; other site 394503000427 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 394503000428 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 394503000429 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 394503000430 mannonate dehydratase; Provisional; Region: PRK03906 394503000431 mannonate dehydratase; Region: uxuA; TIGR00695 394503000432 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 394503000433 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 394503000434 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 394503000435 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 394503000436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000437 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503000438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000439 dimer interface [polypeptide binding]; other site 394503000440 conserved gate region; other site 394503000441 ABC-ATPase subunit interface; other site 394503000442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000444 dimer interface [polypeptide binding]; other site 394503000445 conserved gate region; other site 394503000446 putative PBP binding loops; other site 394503000447 ABC-ATPase subunit interface; other site 394503000448 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503000449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503000450 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 394503000451 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 394503000452 putative active site [active] 394503000453 putative metal binding site [ion binding]; other site 394503000454 Response regulator receiver domain; Region: Response_reg; pfam00072 394503000455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503000456 active site 394503000457 phosphorylation site [posttranslational modification] 394503000458 intermolecular recognition site; other site 394503000459 dimerization interface [polypeptide binding]; other site 394503000460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503000462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503000463 HAMP domain; Region: HAMP; pfam00672 394503000464 dimerization interface [polypeptide binding]; other site 394503000465 Histidine kinase; Region: His_kinase; pfam06580 394503000466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503000467 ATP binding site [chemical binding]; other site 394503000468 Mg2+ binding site [ion binding]; other site 394503000469 G-X-G motif; other site 394503000470 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 394503000471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503000472 active site 394503000473 phosphorylation site [posttranslational modification] 394503000474 intermolecular recognition site; other site 394503000475 dimerization interface [polypeptide binding]; other site 394503000476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503000479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503000480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000482 dimer interface [polypeptide binding]; other site 394503000483 conserved gate region; other site 394503000484 putative PBP binding loops; other site 394503000485 ABC-ATPase subunit interface; other site 394503000486 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503000487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000488 dimer interface [polypeptide binding]; other site 394503000489 ABC-ATPase subunit interface; other site 394503000490 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 394503000491 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 394503000492 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503000493 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 394503000494 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 394503000495 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 394503000496 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 394503000497 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 394503000498 homodimer interface [polypeptide binding]; other site 394503000499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503000500 catalytic residue [active] 394503000501 thymidylate kinase; Validated; Region: tmk; PRK00698 394503000502 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 394503000503 TMP-binding site; other site 394503000504 ATP-binding site [chemical binding]; other site 394503000505 Protein of unknown function (DUF970); Region: DUF970; pfam06153 394503000506 Protein of unknown function (DUF327); Region: DUF327; pfam03885 394503000507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000508 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 394503000509 Walker A motif; other site 394503000510 ATP binding site [chemical binding]; other site 394503000511 Walker B motif; other site 394503000512 arginine finger; other site 394503000513 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 394503000514 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503000515 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503000516 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 394503000517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503000518 S-adenosylmethionine binding site [chemical binding]; other site 394503000519 Predicted methyltransferases [General function prediction only]; Region: COG0313 394503000520 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 394503000521 putative SAM binding site [chemical binding]; other site 394503000522 putative homodimer interface [polypeptide binding]; other site 394503000523 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 394503000524 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 394503000525 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 394503000526 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 394503000527 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 394503000528 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 394503000529 active site 394503000530 Domain of unknown function (DUF348); Region: DUF348; pfam03990 394503000531 Domain of unknown function (DUF348); Region: DUF348; pfam03990 394503000532 G5 domain; Region: G5; pfam07501 394503000533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 394503000534 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 394503000535 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 394503000536 Hemerythrin; Region: Hemerythrin; cd12107 394503000537 Fe binding site [ion binding]; other site 394503000538 Cell division protein ZapA; Region: ZapA; pfam05164 394503000539 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 394503000540 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 394503000541 Peptidase family U32; Region: Peptidase_U32; pfam01136 394503000542 Collagenase; Region: DUF3656; pfam12392 394503000543 Peptidase family U32; Region: Peptidase_U32; cl03113 394503000544 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 394503000545 trimer interface [polypeptide binding]; other site 394503000546 active site 394503000547 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 394503000548 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 394503000549 HflX GTPase family; Region: HflX; cd01878 394503000550 G1 box; other site 394503000551 GTP/Mg2+ binding site [chemical binding]; other site 394503000552 Switch I region; other site 394503000553 G2 box; other site 394503000554 G3 box; other site 394503000555 Switch II region; other site 394503000556 G4 box; other site 394503000557 G5 box; other site 394503000558 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 394503000559 active site 394503000560 Ap6A binding site [chemical binding]; other site 394503000561 nudix motif; other site 394503000562 metal binding site [ion binding]; metal-binding site 394503000563 Uncharacterized conserved protein [Function unknown]; Region: COG1739 394503000564 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 394503000565 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 394503000566 hypothetical protein; Validated; Region: PRK00110 394503000567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503000568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000569 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 394503000570 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 394503000571 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 394503000572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503000573 S-adenosylmethionine binding site [chemical binding]; other site 394503000574 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 394503000575 putative ADP-ribose binding site [chemical binding]; other site 394503000576 putative active site [active] 394503000577 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 394503000578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 394503000579 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 394503000580 metal ion-dependent adhesion site (MIDAS); other site 394503000581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503000582 Zn2+ binding site [ion binding]; other site 394503000583 Mg2+ binding site [ion binding]; other site 394503000584 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503000585 Zn2+ binding site [ion binding]; other site 394503000586 Mg2+ binding site [ion binding]; other site 394503000587 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 394503000588 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503000589 Walker A/P-loop; other site 394503000590 ATP binding site [chemical binding]; other site 394503000591 Q-loop/lid; other site 394503000592 ABC transporter signature motif; other site 394503000593 Walker B; other site 394503000594 D-loop; other site 394503000595 H-loop/switch region; other site 394503000596 Predicted membrane protein [Function unknown]; Region: COG4905 394503000597 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 394503000598 Response regulator receiver domain; Region: Response_reg; pfam00072 394503000599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503000600 active site 394503000601 phosphorylation site [posttranslational modification] 394503000602 intermolecular recognition site; other site 394503000603 dimerization interface [polypeptide binding]; other site 394503000604 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 394503000605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503000607 HAMP domain; Region: HAMP; pfam00672 394503000608 dimerization interface [polypeptide binding]; other site 394503000609 Histidine kinase; Region: His_kinase; pfam06580 394503000610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503000611 ATP binding site [chemical binding]; other site 394503000612 Mg2+ binding site [ion binding]; other site 394503000613 G-X-G motif; other site 394503000614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503000615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503000616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000617 dimer interface [polypeptide binding]; other site 394503000618 conserved gate region; other site 394503000619 putative PBP binding loops; other site 394503000620 ABC-ATPase subunit interface; other site 394503000621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503000622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503000623 dimer interface [polypeptide binding]; other site 394503000624 conserved gate region; other site 394503000625 putative PBP binding loops; other site 394503000626 ABC-ATPase subunit interface; other site 394503000627 Probable beta-xylosidase; Provisional; Region: PLN03080 394503000628 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 394503000629 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 394503000630 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 394503000631 Transcription antiterminator [Transcription]; Region: NusG; COG0250 394503000632 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 394503000633 heterodimer interface [polypeptide binding]; other site 394503000634 homodimer interface [polypeptide binding]; other site 394503000635 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 394503000636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 394503000637 active site 394503000638 HIGH motif; other site 394503000639 nucleotide binding site [chemical binding]; other site 394503000640 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 394503000641 KMSKS motif; other site 394503000642 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 394503000643 tRNA binding surface [nucleotide binding]; other site 394503000644 anticodon binding site; other site 394503000645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503000646 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503000647 Transposase; Region: HTH_Tnp_1; cl17663 394503000648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503000649 HTH-like domain; Region: HTH_21; pfam13276 394503000650 Integrase core domain; Region: rve; pfam00665 394503000651 Integrase core domain; Region: rve_2; pfam13333 394503000652 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 394503000653 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 394503000654 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 394503000655 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 394503000656 hypothetical protein; Provisional; Region: PRK06851 394503000657 Virulence-associated protein E; Region: VirE; pfam05272 394503000658 NTPase; Region: NTPase_1; cl17478 394503000659 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 394503000660 active site 394503000661 substrate-binding site [chemical binding]; other site 394503000662 metal-binding site [ion binding] 394503000663 GTP binding site [chemical binding]; other site 394503000664 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 394503000665 Glucuronate isomerase; Region: UxaC; pfam02614 394503000666 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 394503000667 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 394503000668 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 394503000669 catalytic residues [active] 394503000670 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 394503000671 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 394503000672 Predicted transcriptional regulators [Transcription]; Region: COG1695 394503000673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503000674 putative DNA binding site [nucleotide binding]; other site 394503000675 putative Zn2+ binding site [ion binding]; other site 394503000676 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 394503000677 Methyltransferase domain; Region: Methyltransf_23; pfam13489 394503000678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503000679 S-adenosylmethionine binding site [chemical binding]; other site 394503000680 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503000681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503000682 dimer interface [polypeptide binding]; other site 394503000683 putative CheW interface [polypeptide binding]; other site 394503000684 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503000685 Winged helix-turn helix; Region: HTH_29; pfam13551 394503000686 Homeodomain-like domain; Region: HTH_32; pfam13565 394503000687 Integrase core domain; Region: rve; pfam00665 394503000688 Integrase core domain; Region: rve_3; pfam13683 394503000689 CHASE3 domain; Region: CHASE3; pfam05227 394503000690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503000691 dimerization interface [polypeptide binding]; other site 394503000692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503000693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503000694 dimer interface [polypeptide binding]; other site 394503000695 putative CheW interface [polypeptide binding]; other site 394503000696 Predicted transcriptional regulators [Transcription]; Region: COG1725 394503000697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503000698 DNA-binding site [nucleotide binding]; DNA binding site 394503000699 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503000700 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503000701 Walker A/P-loop; other site 394503000702 ATP binding site [chemical binding]; other site 394503000703 Q-loop/lid; other site 394503000704 ABC transporter signature motif; other site 394503000705 Walker B; other site 394503000706 D-loop; other site 394503000707 H-loop/switch region; other site 394503000708 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 394503000709 Sporulation and spore germination; Region: Germane; pfam10646 394503000710 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 394503000711 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503000712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503000713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503000714 DNA binding residues [nucleotide binding] 394503000715 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 394503000716 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 394503000717 nudix motif; other site 394503000718 endoglucanase; Region: PLN02420 394503000719 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503000720 Cellulose binding domain; Region: CBM_3; smart01067 394503000721 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503000722 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 394503000723 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 394503000724 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 394503000725 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 394503000726 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 394503000727 Soluble P-type ATPase [General function prediction only]; Region: COG4087 394503000728 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 394503000729 metal-binding site [ion binding] 394503000730 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 394503000731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503000732 dimerization interface [polypeptide binding]; other site 394503000733 putative DNA binding site [nucleotide binding]; other site 394503000734 putative Zn2+ binding site [ion binding]; other site 394503000735 YabG peptidase U57; Region: Peptidase_U57; cl05250 394503000736 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 394503000737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503000738 Walker A motif; other site 394503000739 ATP binding site [chemical binding]; other site 394503000740 Walker B motif; other site 394503000741 arginine finger; other site 394503000742 hypothetical protein; Validated; Region: PRK00153 394503000743 recombination protein RecR; Reviewed; Region: recR; PRK00076 394503000744 RecR protein; Region: RecR; pfam02132 394503000745 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 394503000746 putative active site [active] 394503000747 putative metal-binding site [ion binding]; other site 394503000748 tetramer interface [polypeptide binding]; other site 394503000749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503000751 active site 394503000752 phosphorylation site [posttranslational modification] 394503000753 intermolecular recognition site; other site 394503000754 dimerization interface [polypeptide binding]; other site 394503000755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503000756 DNA binding site [nucleotide binding] 394503000757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503000758 HAMP domain; Region: HAMP; pfam00672 394503000759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503000760 dimer interface [polypeptide binding]; other site 394503000761 phosphorylation site [posttranslational modification] 394503000762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503000763 ATP binding site [chemical binding]; other site 394503000764 Mg2+ binding site [ion binding]; other site 394503000765 G-X-G motif; other site 394503000766 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 394503000767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 394503000768 DRTGG domain; Region: DRTGG; pfam07085 394503000769 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 394503000770 DHH family; Region: DHH; pfam01368 394503000771 DHHA2 domain; Region: DHHA2; pfam02833 394503000772 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 394503000773 putative metal binding residues [ion binding]; other site 394503000774 signature motif; other site 394503000775 dimer interface [polypeptide binding]; other site 394503000776 active site 394503000777 polyP binding site; other site 394503000778 substrate binding site [chemical binding]; other site 394503000779 acceptor-phosphate pocket; other site 394503000780 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 394503000781 CotH protein; Region: CotH; pfam08757 394503000782 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 394503000783 Domain of unknown function DUF21; Region: DUF21; pfam01595 394503000784 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 394503000785 Transporter associated domain; Region: CorC_HlyC; pfam03471 394503000786 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 394503000787 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 394503000788 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 394503000789 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 394503000790 peptide chain release factor 1; Validated; Region: prfA; PRK00591 394503000791 This domain is found in peptide chain release factors; Region: PCRF; smart00937 394503000792 RF-1 domain; Region: RF-1; pfam00472 394503000793 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 394503000794 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 394503000795 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 394503000796 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 394503000797 Low molecular weight phosphatase family; Region: LMWPc; cd00115 394503000798 active site 394503000799 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 394503000800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503000801 active site 394503000802 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 394503000803 catalytic motif [active] 394503000804 Zn binding site [ion binding]; other site 394503000805 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 394503000806 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 394503000807 Mg++ binding site [ion binding]; other site 394503000808 putative catalytic motif [active] 394503000809 substrate binding site [chemical binding]; other site 394503000810 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 394503000811 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 394503000812 active site 394503000813 homodimer interface [polypeptide binding]; other site 394503000814 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 394503000815 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 394503000816 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 394503000817 ligand binding site [chemical binding]; other site 394503000818 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 394503000819 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 394503000820 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 394503000821 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 394503000822 ATP synthase subunit C; Region: ATP-synt_C; cl00466 394503000823 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 394503000824 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 394503000825 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 394503000826 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 394503000827 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 394503000828 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 394503000829 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 394503000830 beta subunit interaction interface [polypeptide binding]; other site 394503000831 Walker A motif; other site 394503000832 ATP binding site [chemical binding]; other site 394503000833 Walker B motif; other site 394503000834 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 394503000835 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 394503000836 core domain interface [polypeptide binding]; other site 394503000837 delta subunit interface [polypeptide binding]; other site 394503000838 epsilon subunit interface [polypeptide binding]; other site 394503000839 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 394503000840 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 394503000841 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 394503000842 alpha subunit interaction interface [polypeptide binding]; other site 394503000843 Walker A motif; other site 394503000844 ATP binding site [chemical binding]; other site 394503000845 Walker B motif; other site 394503000846 inhibitor binding site; inhibition site 394503000847 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 394503000848 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 394503000849 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 394503000850 gamma subunit interface [polypeptide binding]; other site 394503000851 epsilon subunit interface [polypeptide binding]; other site 394503000852 LBP interface [polypeptide binding]; other site 394503000853 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000854 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000855 Interdomain contacts; other site 394503000856 Cytokine receptor motif; other site 394503000857 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000858 Interdomain contacts; other site 394503000859 Cytokine receptor motif; other site 394503000860 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000861 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000862 Interdomain contacts; other site 394503000863 Cytokine receptor motif; other site 394503000864 S-layer homology domain; Region: SLH; pfam00395 394503000865 S-layer homology domain; Region: SLH; pfam00395 394503000866 S-layer homology domain; Region: SLH; pfam00395 394503000867 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 394503000868 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503000869 Interdomain contacts; other site 394503000870 Cytokine receptor motif; other site 394503000871 S-layer homology domain; Region: SLH; pfam00395 394503000872 S-layer homology domain; Region: SLH; pfam00395 394503000873 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 394503000874 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 394503000875 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 394503000876 hinge; other site 394503000877 active site 394503000878 stage II sporulation protein D; Region: spore_II_D; TIGR02870 394503000879 Stage II sporulation protein; Region: SpoIID; pfam08486 394503000880 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 394503000881 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503000882 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 394503000883 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 394503000884 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 394503000885 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 394503000886 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 394503000887 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 394503000888 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 394503000889 active site 394503000890 HIGH motif; other site 394503000891 KMSK motif region; other site 394503000892 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 394503000893 tRNA binding surface [nucleotide binding]; other site 394503000894 anticodon binding site; other site 394503000895 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503000896 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 394503000897 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 394503000898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503000899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503000900 dimer interface [polypeptide binding]; other site 394503000901 putative CheW interface [polypeptide binding]; other site 394503000902 S-layer homology domain; Region: SLH; pfam00395 394503000903 S-layer homology domain; Region: SLH; pfam00395 394503000904 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 394503000905 C-terminal peptidase (prc); Region: prc; TIGR00225 394503000906 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 394503000907 protein binding site [polypeptide binding]; other site 394503000908 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 394503000909 Catalytic dyad [active] 394503000910 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503000911 CTP synthetase; Validated; Region: pyrG; PRK05380 394503000912 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 394503000913 Catalytic site [active] 394503000914 active site 394503000915 UTP binding site [chemical binding]; other site 394503000916 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 394503000917 active site 394503000918 putative oxyanion hole; other site 394503000919 catalytic triad [active] 394503000920 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 394503000921 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 394503000922 MgtC family; Region: MgtC; pfam02308 394503000923 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 394503000924 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 394503000925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 394503000926 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 394503000927 Soluble P-type ATPase [General function prediction only]; Region: COG4087 394503000928 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 394503000929 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 394503000930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503000931 Walker A/P-loop; other site 394503000932 ATP binding site [chemical binding]; other site 394503000933 Q-loop/lid; other site 394503000934 ABC transporter signature motif; other site 394503000935 Walker B; other site 394503000936 D-loop; other site 394503000937 H-loop/switch region; other site 394503000938 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 394503000939 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 394503000940 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 394503000941 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 394503000942 Uncharacterized membrane protein [Function unknown]; Region: COG3949 394503000943 PQQ-like domain; Region: PQQ_2; pfam13360 394503000944 Colicin V production protein; Region: Colicin_V; pfam02674 394503000945 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 394503000946 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 394503000947 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 394503000948 PYR/PP interface [polypeptide binding]; other site 394503000949 dimer interface [polypeptide binding]; other site 394503000950 TPP binding site [chemical binding]; other site 394503000951 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 394503000952 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 394503000953 TPP-binding site [chemical binding]; other site 394503000954 dimer interface [polypeptide binding]; other site 394503000955 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 394503000956 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 394503000957 ATP binding site [chemical binding]; other site 394503000958 Mg++ binding site [ion binding]; other site 394503000959 motif III; other site 394503000960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503000961 nucleotide binding region [chemical binding]; other site 394503000962 ATP-binding site [chemical binding]; other site 394503000963 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 394503000964 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 394503000965 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 394503000966 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 394503000967 putative homodimer interface [polypeptide binding]; other site 394503000968 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 394503000969 heterodimer interface [polypeptide binding]; other site 394503000970 homodimer interface [polypeptide binding]; other site 394503000971 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 394503000972 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 394503000973 23S rRNA interface [nucleotide binding]; other site 394503000974 L7/L12 interface [polypeptide binding]; other site 394503000975 putative thiostrepton binding site; other site 394503000976 L25 interface [polypeptide binding]; other site 394503000977 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 394503000978 mRNA/rRNA interface [nucleotide binding]; other site 394503000979 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 394503000980 23S rRNA interface [nucleotide binding]; other site 394503000981 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 394503000982 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 394503000983 core dimer interface [polypeptide binding]; other site 394503000984 peripheral dimer interface [polypeptide binding]; other site 394503000985 L10 interface [polypeptide binding]; other site 394503000986 L11 interface [polypeptide binding]; other site 394503000987 putative EF-Tu interaction site [polypeptide binding]; other site 394503000988 putative EF-G interaction site [polypeptide binding]; other site 394503000989 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 394503000990 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 394503000991 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 394503000992 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 394503000993 RPB1 interaction site [polypeptide binding]; other site 394503000994 RPB10 interaction site [polypeptide binding]; other site 394503000995 RPB11 interaction site [polypeptide binding]; other site 394503000996 RPB3 interaction site [polypeptide binding]; other site 394503000997 RPB12 interaction site [polypeptide binding]; other site 394503000998 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 394503000999 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 394503001000 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 394503001001 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 394503001002 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 394503001003 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 394503001004 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 394503001005 G-loop; other site 394503001006 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 394503001007 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 394503001008 DNA binding site [nucleotide binding] 394503001009 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 394503001010 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 394503001011 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 394503001012 S17 interaction site [polypeptide binding]; other site 394503001013 S8 interaction site; other site 394503001014 16S rRNA interaction site [nucleotide binding]; other site 394503001015 streptomycin interaction site [chemical binding]; other site 394503001016 23S rRNA interaction site [nucleotide binding]; other site 394503001017 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 394503001018 30S ribosomal protein S7; Validated; Region: PRK05302 394503001019 elongation factor G; Reviewed; Region: PRK00007 394503001020 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 394503001021 G1 box; other site 394503001022 putative GEF interaction site [polypeptide binding]; other site 394503001023 GTP/Mg2+ binding site [chemical binding]; other site 394503001024 Switch I region; other site 394503001025 G2 box; other site 394503001026 G3 box; other site 394503001027 Switch II region; other site 394503001028 G4 box; other site 394503001029 G5 box; other site 394503001030 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 394503001031 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 394503001032 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 394503001033 elongation factor Tu; Reviewed; Region: PRK00049 394503001034 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 394503001035 G1 box; other site 394503001036 GEF interaction site [polypeptide binding]; other site 394503001037 GTP/Mg2+ binding site [chemical binding]; other site 394503001038 Switch I region; other site 394503001039 G2 box; other site 394503001040 G3 box; other site 394503001041 Switch II region; other site 394503001042 G4 box; other site 394503001043 G5 box; other site 394503001044 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 394503001045 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 394503001046 Antibiotic Binding Site [chemical binding]; other site 394503001047 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 394503001048 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 394503001049 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 394503001050 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 394503001051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 394503001052 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 394503001053 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 394503001054 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 394503001055 GGGtGRT protein; Region: GGGtGRT; pfam14057 394503001056 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 394503001057 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 394503001058 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 394503001059 UvrB/uvrC motif; Region: UVR; pfam02151 394503001060 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 394503001061 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 394503001062 ADP binding site [chemical binding]; other site 394503001063 phosphagen binding site; other site 394503001064 substrate specificity loop; other site 394503001065 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 394503001066 Clp amino terminal domain; Region: Clp_N; pfam02861 394503001067 Clp amino terminal domain; Region: Clp_N; pfam02861 394503001068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503001069 Walker A motif; other site 394503001070 ATP binding site [chemical binding]; other site 394503001071 Walker B motif; other site 394503001072 arginine finger; other site 394503001073 UvrB/uvrC motif; Region: UVR; pfam02151 394503001074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503001075 Walker A motif; other site 394503001076 ATP binding site [chemical binding]; other site 394503001077 Walker B motif; other site 394503001078 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 394503001079 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 394503001080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503001081 FeS/SAM binding site; other site 394503001082 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 394503001083 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 394503001084 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 394503001085 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 394503001086 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 394503001087 DXD motif; other site 394503001088 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 394503001089 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 394503001090 DNA repair protein RadA; Provisional; Region: PRK11823 394503001091 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503001092 Walker A motif; other site 394503001093 ATP binding site [chemical binding]; other site 394503001094 Walker B motif; other site 394503001095 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 394503001096 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 394503001097 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 394503001098 Helix-hairpin-helix motif; Region: HHH; pfam00633 394503001099 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503001100 Winged helix-turn helix; Region: HTH_29; pfam13551 394503001101 Homeodomain-like domain; Region: HTH_32; pfam13565 394503001102 Integrase core domain; Region: rve; pfam00665 394503001103 Integrase core domain; Region: rve_3; pfam13683 394503001104 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 394503001105 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 394503001106 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 394503001107 putative active site [active] 394503001108 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 394503001109 substrate binding site; other site 394503001110 dimer interface; other site 394503001111 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503001112 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503001113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503001114 Walker A/P-loop; other site 394503001115 ATP binding site [chemical binding]; other site 394503001116 Q-loop/lid; other site 394503001117 ABC transporter signature motif; other site 394503001118 Walker B; other site 394503001119 D-loop; other site 394503001120 H-loop/switch region; other site 394503001121 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 394503001122 homotrimer interaction site [polypeptide binding]; other site 394503001123 zinc binding site [ion binding]; other site 394503001124 CDP-binding sites; other site 394503001125 prolyl-tRNA synthetase; Provisional; Region: PRK08661 394503001126 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 394503001127 dimer interface [polypeptide binding]; other site 394503001128 motif 1; other site 394503001129 active site 394503001130 motif 2; other site 394503001131 motif 3; other site 394503001132 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 394503001133 anticodon binding site; other site 394503001134 zinc-binding site [ion binding]; other site 394503001135 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503001136 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 394503001137 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 394503001138 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 394503001139 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 394503001140 active site 394503001141 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 394503001142 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 394503001143 active site 394503001144 Substrate binding site; other site 394503001145 Mg++ binding site; other site 394503001146 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 394503001147 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 394503001148 putative trimer interface [polypeptide binding]; other site 394503001149 putative CoA binding site [chemical binding]; other site 394503001150 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 394503001151 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 394503001152 Predicted membrane protein [Function unknown]; Region: COG2246 394503001153 GtrA-like protein; Region: GtrA; pfam04138 394503001154 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 394503001155 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 394503001156 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 394503001157 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 394503001158 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 394503001159 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 394503001160 RNA binding site [nucleotide binding]; other site 394503001161 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 394503001162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 394503001163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503001164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503001165 ATP binding site [chemical binding]; other site 394503001166 Mg2+ binding site [ion binding]; other site 394503001167 G-X-G motif; other site 394503001168 Sporulation and spore germination; Region: Germane; pfam10646 394503001169 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 394503001170 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 394503001171 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 394503001172 putative DNA binding site [nucleotide binding]; other site 394503001173 putative homodimer interface [polypeptide binding]; other site 394503001174 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 394503001175 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 394503001176 active site 394503001177 DNA binding site [nucleotide binding] 394503001178 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 394503001179 DNA binding site [nucleotide binding] 394503001180 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 394503001181 nucleotide binding site [chemical binding]; other site 394503001182 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 394503001183 UDP-glucose 4-epimerase; Region: PLN02240 394503001184 NAD binding site [chemical binding]; other site 394503001185 homodimer interface [polypeptide binding]; other site 394503001186 active site 394503001187 substrate binding site [chemical binding]; other site 394503001188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 394503001189 active site 394503001190 Probable zinc-binding domain; Region: zf-trcl; pfam13451 394503001191 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 394503001192 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 394503001193 30S subunit binding site; other site 394503001194 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 394503001195 Sulfatase; Region: Sulfatase; cl17466 394503001196 shikimate kinase; Reviewed; Region: aroK; PRK00131 394503001197 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 394503001198 ADP binding site [chemical binding]; other site 394503001199 magnesium binding site [ion binding]; other site 394503001200 putative shikimate binding site; other site 394503001201 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 394503001202 Part of AAA domain; Region: AAA_19; pfam13245 394503001203 Family description; Region: UvrD_C_2; pfam13538 394503001204 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 394503001205 beta-galactosidase; Region: BGL; TIGR03356 394503001206 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 394503001207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503001208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503001209 DNA binding residues [nucleotide binding] 394503001210 Putative zinc-finger; Region: zf-HC2; pfam13490 394503001211 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 394503001212 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 394503001213 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503001214 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 394503001215 sugar binding site [chemical binding]; other site 394503001216 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 394503001217 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 394503001218 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503001219 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 394503001220 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 394503001221 dimer interface [polypeptide binding]; other site 394503001222 motif 1; other site 394503001223 active site 394503001224 motif 2; other site 394503001225 motif 3; other site 394503001226 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 394503001227 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 394503001228 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 394503001229 histidinol dehydrogenase; Region: hisD; TIGR00069 394503001230 NAD binding site [chemical binding]; other site 394503001231 dimerization interface [polypeptide binding]; other site 394503001232 product binding site; other site 394503001233 substrate binding site [chemical binding]; other site 394503001234 zinc binding site [ion binding]; other site 394503001235 catalytic residues [active] 394503001236 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 394503001237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503001238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503001239 homodimer interface [polypeptide binding]; other site 394503001240 catalytic residue [active] 394503001241 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 394503001242 putative active site pocket [active] 394503001243 4-fold oligomerization interface [polypeptide binding]; other site 394503001244 metal binding residues [ion binding]; metal-binding site 394503001245 3-fold/trimer interface [polypeptide binding]; other site 394503001246 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 394503001247 ATP binding site [chemical binding]; other site 394503001248 active site 394503001249 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 394503001250 substrate binding site [chemical binding]; other site 394503001251 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 394503001252 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 394503001253 putative active site [active] 394503001254 oxyanion strand; other site 394503001255 catalytic triad [active] 394503001256 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 394503001257 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 394503001258 catalytic residues [active] 394503001259 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 394503001260 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 394503001261 substrate binding site [chemical binding]; other site 394503001262 glutamase interaction surface [polypeptide binding]; other site 394503001263 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 394503001264 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 394503001265 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 394503001266 metal binding site [ion binding]; metal-binding site 394503001267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001268 binding surface 394503001269 TPR motif; other site 394503001270 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 394503001271 oligomerisation interface [polypeptide binding]; other site 394503001272 mobile loop; other site 394503001273 roof hairpin; other site 394503001274 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 394503001275 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 394503001276 ring oligomerisation interface [polypeptide binding]; other site 394503001277 ATP/Mg binding site [chemical binding]; other site 394503001278 stacking interactions; other site 394503001279 hinge regions; other site 394503001280 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 394503001281 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 394503001282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 394503001283 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 394503001284 active site 394503001285 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 394503001286 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 394503001287 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 394503001288 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 394503001289 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 394503001290 dimer interface [polypeptide binding]; other site 394503001291 putative anticodon binding site; other site 394503001292 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 394503001293 motif 1; other site 394503001294 active site 394503001295 motif 2; other site 394503001296 motif 3; other site 394503001297 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 394503001298 anti sigma factor interaction site; other site 394503001299 regulatory phosphorylation site [posttranslational modification]; other site 394503001300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 394503001301 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 394503001302 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 394503001303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503001304 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 394503001305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503001306 DNA binding residues [nucleotide binding] 394503001307 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 394503001308 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 394503001309 ATP binding site [chemical binding]; other site 394503001310 Mg2+ binding site [ion binding]; other site 394503001311 G-X-G motif; other site 394503001312 Transposase; Region: HTH_Tnp_1; pfam01527 394503001313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503001314 putative transposase OrfB; Reviewed; Region: PHA02517 394503001315 HTH-like domain; Region: HTH_21; pfam13276 394503001316 Integrase core domain; Region: rve; pfam00665 394503001317 Integrase core domain; Region: rve_3; pfam13683 394503001318 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 394503001319 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 394503001320 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503001321 Winged helix-turn helix; Region: HTH_29; pfam13551 394503001322 Homeodomain-like domain; Region: HTH_32; pfam13565 394503001323 Integrase core domain; Region: rve; pfam00665 394503001324 Integrase core domain; Region: rve_3; pfam13683 394503001325 MarR family; Region: MarR_2; pfam12802 394503001326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503001327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 394503001328 putative substrate translocation pore; other site 394503001329 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 394503001330 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 394503001331 dimer interface [polypeptide binding]; other site 394503001332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503001333 catalytic residue [active] 394503001334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503001335 active site 394503001336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 394503001337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503001338 catalytic residue [active] 394503001339 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 394503001340 EamA-like transporter family; Region: EamA; pfam00892 394503001341 hypothetical protein; Provisional; Region: PRK07206 394503001342 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 394503001343 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 394503001344 metal binding site [ion binding]; metal-binding site 394503001345 active site 394503001346 Transposase, Mutator family; Region: Transposase_mut; pfam00872 394503001347 MULE transposase domain; Region: MULE; pfam10551 394503001348 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 394503001349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503001350 putative substrate translocation pore; other site 394503001351 VanW like protein; Region: VanW; pfam04294 394503001352 EamA-like transporter family; Region: EamA; cl17759 394503001353 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 394503001354 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 394503001355 homodimer interface [polypeptide binding]; other site 394503001356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503001357 catalytic residue [active] 394503001358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 394503001359 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503001360 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503001361 catalytic residues [active] 394503001362 catalytic nucleophile [active] 394503001363 Recombinase; Region: Recombinase; pfam07508 394503001364 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503001365 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503001366 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 394503001367 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 394503001368 S-layer homology domain; Region: SLH; pfam00395 394503001369 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 394503001370 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 394503001371 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503001372 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503001373 catalytic residues [active] 394503001374 catalytic nucleophile [active] 394503001375 Recombinase; Region: Recombinase; pfam07508 394503001376 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503001377 CotJB protein; Region: CotJB; pfam12652 394503001378 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 394503001379 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 394503001380 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 394503001381 Walker A/P-loop; other site 394503001382 ATP binding site [chemical binding]; other site 394503001383 Q-loop/lid; other site 394503001384 ABC transporter signature motif; other site 394503001385 Walker B; other site 394503001386 D-loop; other site 394503001387 H-loop/switch region; other site 394503001388 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 394503001389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 394503001390 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 394503001391 NMT1-like family; Region: NMT1_2; pfam13379 394503001392 substrate binding pocket [chemical binding]; other site 394503001393 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503001394 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 394503001395 ACS interaction site; other site 394503001396 CODH interaction site; other site 394503001397 metal cluster binding site [ion binding]; other site 394503001398 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503001399 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 394503001400 catalytic residues [active] 394503001401 catalytic nucleophile [active] 394503001402 Presynaptic Site I dimer interface [polypeptide binding]; other site 394503001403 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 394503001404 Synaptic Flat tetramer interface [polypeptide binding]; other site 394503001405 Synaptic Site I dimer interface [polypeptide binding]; other site 394503001406 DNA binding site [nucleotide binding] 394503001407 Recombinase; Region: Recombinase; pfam07508 394503001408 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503001409 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 394503001410 MATE family multidrug exporter; Provisional; Region: PRK10189 394503001411 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 394503001412 rRNA interaction site [nucleotide binding]; other site 394503001413 S8 interaction site; other site 394503001414 putative laminin-1 binding site; other site 394503001415 elongation factor Ts; Reviewed; Region: tsf; PRK12332 394503001416 UBA/TS-N domain; Region: UBA; pfam00627 394503001417 Elongation factor TS; Region: EF_TS; pfam00889 394503001418 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 394503001419 putative nucleotide binding site [chemical binding]; other site 394503001420 uridine monophosphate binding site [chemical binding]; other site 394503001421 homohexameric interface [polypeptide binding]; other site 394503001422 ribosome recycling factor; Reviewed; Region: frr; PRK00083 394503001423 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 394503001424 hinge region; other site 394503001425 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 394503001426 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 394503001427 catalytic residue [active] 394503001428 putative FPP diphosphate binding site; other site 394503001429 putative FPP binding hydrophobic cleft; other site 394503001430 dimer interface [polypeptide binding]; other site 394503001431 putative IPP diphosphate binding site; other site 394503001432 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 394503001433 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 394503001434 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 394503001435 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 394503001436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 394503001437 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 394503001438 RIP metalloprotease RseP; Region: TIGR00054 394503001439 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 394503001440 active site 394503001441 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 394503001442 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 394503001443 protein binding site [polypeptide binding]; other site 394503001444 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 394503001445 putative substrate binding region [chemical binding]; other site 394503001446 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 394503001447 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 394503001448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 394503001449 DNA polymerase III PolC; Validated; Region: polC; PRK00448 394503001450 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 394503001451 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 394503001452 generic binding surface II; other site 394503001453 generic binding surface I; other site 394503001454 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 394503001455 active site 394503001456 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 394503001457 active site 394503001458 catalytic site [active] 394503001459 substrate binding site [chemical binding]; other site 394503001460 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 394503001461 active site 394503001462 ribosome maturation protein RimP; Reviewed; Region: PRK00092 394503001463 Sm and related proteins; Region: Sm_like; cl00259 394503001464 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 394503001465 putative oligomer interface [polypeptide binding]; other site 394503001466 putative RNA binding site [nucleotide binding]; other site 394503001467 transcription termination factor NusA; Region: NusA; TIGR01953 394503001468 NusA N-terminal domain; Region: NusA_N; pfam08529 394503001469 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 394503001470 RNA binding site [nucleotide binding]; other site 394503001471 homodimer interface [polypeptide binding]; other site 394503001472 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 394503001473 G-X-X-G motif; other site 394503001474 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 394503001475 G-X-X-G motif; other site 394503001476 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 394503001477 putative RNA binding cleft [nucleotide binding]; other site 394503001478 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 394503001479 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 394503001480 Semenogelin; Region: Semenogelin; pfam05474 394503001481 translation initiation factor IF-2; Validated; Region: infB; PRK05306 394503001482 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 394503001483 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 394503001484 G1 box; other site 394503001485 putative GEF interaction site [polypeptide binding]; other site 394503001486 GTP/Mg2+ binding site [chemical binding]; other site 394503001487 Switch I region; other site 394503001488 G2 box; other site 394503001489 G3 box; other site 394503001490 Switch II region; other site 394503001491 G4 box; other site 394503001492 G5 box; other site 394503001493 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 394503001494 Translation-initiation factor 2; Region: IF-2; pfam11987 394503001495 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 394503001496 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 394503001497 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 394503001498 DHH family; Region: DHH; pfam01368 394503001499 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 394503001500 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 394503001501 RNA binding site [nucleotide binding]; other site 394503001502 active site 394503001503 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 394503001504 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 394503001505 active site 394503001506 Riboflavin kinase; Region: Flavokinase; pfam01687 394503001507 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 394503001508 Acylphosphatase; Region: Acylphosphatase; pfam00708 394503001509 HypF finger; Region: zf-HYPF; pfam07503 394503001510 HypF finger; Region: zf-HYPF; pfam07503 394503001511 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 394503001512 HupF/HypC family; Region: HupF_HypC; pfam01455 394503001513 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 394503001514 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 394503001515 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 394503001516 dimerization interface [polypeptide binding]; other site 394503001517 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 394503001518 ATP binding site [chemical binding]; other site 394503001519 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503001520 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503001521 Walker A/P-loop; other site 394503001522 ATP binding site [chemical binding]; other site 394503001523 Q-loop/lid; other site 394503001524 ABC transporter signature motif; other site 394503001525 Walker B; other site 394503001526 D-loop; other site 394503001527 H-loop/switch region; other site 394503001528 Yip1 domain; Region: Yip1; pfam04893 394503001529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 394503001530 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 394503001531 HlyD family secretion protein; Region: HlyD_3; pfam13437 394503001532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 394503001533 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 394503001534 FtsX-like permease family; Region: FtsX; pfam02687 394503001535 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 394503001536 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 394503001537 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 394503001538 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 394503001539 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 394503001540 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 394503001541 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 394503001542 cell division protein MraZ; Reviewed; Region: PRK00326 394503001543 MraZ protein; Region: MraZ; pfam02381 394503001544 MraZ protein; Region: MraZ; pfam02381 394503001545 MraW methylase family; Region: Methyltransf_5; pfam01795 394503001546 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 394503001547 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 394503001548 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 394503001549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 394503001550 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 394503001551 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 394503001552 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 394503001553 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 394503001554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503001555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503001556 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 394503001557 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 394503001558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503001559 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503001560 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 394503001561 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 394503001562 Mg++ binding site [ion binding]; other site 394503001563 putative catalytic motif [active] 394503001564 putative substrate binding site [chemical binding]; other site 394503001565 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 394503001566 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 394503001567 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 394503001568 active site 394503001569 homodimer interface [polypeptide binding]; other site 394503001570 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503001571 uracil transporter; Provisional; Region: PRK10720 394503001572 monogalactosyldiacylglycerol synthase; Region: PLN02605 394503001573 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 394503001574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 394503001575 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 394503001576 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 394503001577 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 394503001578 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503001579 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503001580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503001581 FeS/SAM binding site; other site 394503001582 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 394503001583 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 394503001584 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 394503001585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 394503001586 metal ion-dependent adhesion site (MIDAS); other site 394503001587 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 394503001588 SpoVR like protein; Region: SpoVR; pfam04293 394503001589 heat shock protein 90; Provisional; Region: PRK05218 394503001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503001591 ATP binding site [chemical binding]; other site 394503001592 Mg2+ binding site [ion binding]; other site 394503001593 G-X-G motif; other site 394503001594 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503001595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503001596 dimer interface [polypeptide binding]; other site 394503001597 putative CheW interface [polypeptide binding]; other site 394503001598 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503001599 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 394503001600 acyl-activating enzyme (AAE) consensus motif; other site 394503001601 AMP binding site [chemical binding]; other site 394503001602 active site 394503001603 CoA binding site [chemical binding]; other site 394503001604 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503001605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503001606 non-specific DNA binding site [nucleotide binding]; other site 394503001607 salt bridge; other site 394503001608 sequence-specific DNA binding site [nucleotide binding]; other site 394503001609 Cupin domain; Region: Cupin_2; pfam07883 394503001610 HAMP domain; Region: HAMP; pfam00672 394503001611 dimerization interface [polypeptide binding]; other site 394503001612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503001613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503001614 dimer interface [polypeptide binding]; other site 394503001615 putative CheW interface [polypeptide binding]; other site 394503001616 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 394503001617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503001618 Zn2+ binding site [ion binding]; other site 394503001619 Mg2+ binding site [ion binding]; other site 394503001620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 394503001621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 394503001622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 394503001623 dimerization interface [polypeptide binding]; other site 394503001624 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 394503001625 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 394503001626 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 394503001627 dimerization interface [polypeptide binding]; other site 394503001628 ATP binding site [chemical binding]; other site 394503001629 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 394503001630 dimerization interface [polypeptide binding]; other site 394503001631 ATP binding site [chemical binding]; other site 394503001632 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 394503001633 putative active site [active] 394503001634 catalytic triad [active] 394503001635 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 394503001636 AAA domain; Region: AAA_31; pfam13614 394503001637 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 394503001638 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 394503001639 ATP binding site [chemical binding]; other site 394503001640 Walker A motif; other site 394503001641 hexamer interface [polypeptide binding]; other site 394503001642 Walker B motif; other site 394503001643 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 394503001644 TadE-like protein; Region: TadE; pfam07811 394503001645 TadE-like protein; Region: TadE; pfam07811 394503001646 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 394503001647 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 394503001648 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 394503001649 phosphopeptide binding site; other site 394503001650 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 394503001651 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 394503001652 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 394503001653 active site 394503001654 nucleophile elbow; other site 394503001655 Predicted membrane protein [Function unknown]; Region: COG2510 394503001656 Uncharacterized conserved protein [Function unknown]; Region: COG0432 394503001657 Putative amidase domain; Region: Amidase_6; pfam12671 394503001658 3D domain; Region: 3D; cl01439 394503001659 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 394503001660 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 394503001661 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 394503001662 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 394503001663 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 394503001664 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 394503001665 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 394503001666 Spore germination protein; Region: Spore_permease; cl17796 394503001667 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 394503001668 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 394503001669 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 394503001670 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 394503001671 putative allosteric regulatory residue; other site 394503001672 dihydrodipicolinate reductase; Provisional; Region: PRK00048 394503001673 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 394503001674 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 394503001675 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 394503001676 dihydrodipicolinate synthase; Region: dapA; TIGR00674 394503001677 dimer interface [polypeptide binding]; other site 394503001678 active site 394503001679 catalytic residue [active] 394503001680 Stage II sporulation protein; Region: SpoIID; pfam08486 394503001681 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 394503001682 aspartate kinase; Reviewed; Region: PRK09034 394503001683 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 394503001684 nucleotide binding site [chemical binding]; other site 394503001685 substrate binding site [chemical binding]; other site 394503001686 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 394503001687 allosteric regulatory residue; other site 394503001688 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 394503001689 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 394503001690 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 394503001691 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 394503001692 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 394503001693 Preprotein translocase subunit; Region: YajC; pfam02699 394503001694 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 394503001695 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 394503001696 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 394503001697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503001698 FeS/SAM binding site; other site 394503001699 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 394503001700 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 394503001701 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 394503001702 trimer interface [polypeptide binding]; other site 394503001703 putative metal binding site [ion binding]; other site 394503001704 protein-export membrane protein SecD; Region: secD; TIGR01129 394503001705 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 394503001706 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 394503001707 Protein export membrane protein; Region: SecD_SecF; pfam02355 394503001708 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 394503001709 DNA primase; Validated; Region: dnaG; PRK05667 394503001710 CHC2 zinc finger; Region: zf-CHC2; pfam01807 394503001711 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 394503001712 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 394503001713 active site 394503001714 metal binding site [ion binding]; metal-binding site 394503001715 interdomain interaction site; other site 394503001716 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 394503001717 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 394503001718 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 394503001719 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 394503001720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503001721 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 394503001722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503001723 DNA binding residues [nucleotide binding] 394503001724 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 394503001725 Family of unknown function (DUF633); Region: DUF633; pfam04816 394503001726 Uncharacterized conserved protein [Function unknown]; Region: COG0327 394503001727 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 394503001728 Cell division protein ZapA; Region: ZapA; pfam05164 394503001729 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 394503001730 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 394503001731 active site 394503001732 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 394503001733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 394503001734 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 394503001735 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 394503001736 putative ATP binding site [chemical binding]; other site 394503001737 putative substrate interface [chemical binding]; other site 394503001738 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 394503001739 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 394503001740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503001741 Walker A/P-loop; other site 394503001742 ATP binding site [chemical binding]; other site 394503001743 Q-loop/lid; other site 394503001744 ABC transporter signature motif; other site 394503001745 Walker B; other site 394503001746 D-loop; other site 394503001747 H-loop/switch region; other site 394503001748 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 394503001749 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503001750 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 394503001751 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 394503001752 dimer interface [polypeptide binding]; other site 394503001753 PYR/PP interface [polypeptide binding]; other site 394503001754 TPP binding site [chemical binding]; other site 394503001755 substrate binding site [chemical binding]; other site 394503001756 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 394503001757 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 394503001758 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 394503001759 TPP-binding site [chemical binding]; other site 394503001760 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 394503001761 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 394503001762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503001763 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503001764 Walker A/P-loop; other site 394503001765 ATP binding site [chemical binding]; other site 394503001766 Q-loop/lid; other site 394503001767 ABC transporter signature motif; other site 394503001768 Walker B; other site 394503001769 D-loop; other site 394503001770 H-loop/switch region; other site 394503001771 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 394503001772 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 394503001773 FtsX-like permease family; Region: FtsX; pfam02687 394503001774 FtsX-like permease family; Region: FtsX; pfam02687 394503001775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503001776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503001777 active site 394503001778 phosphorylation site [posttranslational modification] 394503001779 intermolecular recognition site; other site 394503001780 dimerization interface [polypeptide binding]; other site 394503001781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503001782 DNA binding site [nucleotide binding] 394503001783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503001784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503001785 dimer interface [polypeptide binding]; other site 394503001786 phosphorylation site [posttranslational modification] 394503001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503001788 ATP binding site [chemical binding]; other site 394503001789 Mg2+ binding site [ion binding]; other site 394503001790 G-X-G motif; other site 394503001791 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 394503001792 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 394503001793 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 394503001794 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 394503001795 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 394503001796 YmaF family; Region: YmaF; pfam12788 394503001797 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 394503001798 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 394503001799 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 394503001800 active site 394503001801 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 394503001802 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 394503001803 NodB motif; other site 394503001804 active site 394503001805 catalytic site [active] 394503001806 metal binding site [ion binding]; metal-binding site 394503001807 Restriction endonuclease; Region: Mrr_cat; pfam04471 394503001808 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 394503001809 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 394503001810 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 394503001811 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 394503001812 NodB motif; other site 394503001813 active site 394503001814 catalytic site [active] 394503001815 Cd binding site [ion binding]; other site 394503001816 YabP family; Region: YabP; cl06766 394503001817 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 394503001818 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 394503001819 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 394503001820 PhoH-like protein; Region: PhoH; pfam02562 394503001821 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 394503001822 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 394503001823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503001824 Zn2+ binding site [ion binding]; other site 394503001825 Mg2+ binding site [ion binding]; other site 394503001826 metal-binding heat shock protein; Provisional; Region: PRK00016 394503001827 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 394503001828 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 394503001829 active site 394503001830 catalytic motif [active] 394503001831 Zn binding site [ion binding]; other site 394503001832 GTPase Era; Reviewed; Region: era; PRK00089 394503001833 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 394503001834 G1 box; other site 394503001835 GTP/Mg2+ binding site [chemical binding]; other site 394503001836 Switch I region; other site 394503001837 G2 box; other site 394503001838 Switch II region; other site 394503001839 G3 box; other site 394503001840 G4 box; other site 394503001841 G5 box; other site 394503001842 KH domain; Region: KH_2; pfam07650 394503001843 YqzL-like protein; Region: YqzL; pfam14006 394503001844 Recombination protein O N terminal; Region: RecO_N; pfam11967 394503001845 DNA repair protein RecO; Region: reco; TIGR00613 394503001846 Recombination protein O C terminal; Region: RecO_C; pfam02565 394503001847 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 394503001848 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 394503001849 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 394503001850 putative active site [active] 394503001851 catalytic site [active] 394503001852 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 394503001853 putative active site [active] 394503001854 catalytic site [active] 394503001855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503001856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503001857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503001858 Walker A/P-loop; other site 394503001859 ATP binding site [chemical binding]; other site 394503001860 Q-loop/lid; other site 394503001861 ABC transporter signature motif; other site 394503001862 Walker B; other site 394503001863 D-loop; other site 394503001864 H-loop/switch region; other site 394503001865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503001866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503001867 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 394503001868 Walker A/P-loop; other site 394503001869 ATP binding site [chemical binding]; other site 394503001870 Q-loop/lid; other site 394503001871 ABC transporter signature motif; other site 394503001872 Walker B; other site 394503001873 D-loop; other site 394503001874 H-loop/switch region; other site 394503001875 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503001876 Winged helix-turn helix; Region: HTH_29; pfam13551 394503001877 Homeodomain-like domain; Region: HTH_32; pfam13565 394503001878 Integrase core domain; Region: rve; pfam00665 394503001879 Integrase core domain; Region: rve_3; pfam13683 394503001880 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 394503001881 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 394503001882 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503001883 Winged helix-turn helix; Region: HTH_29; pfam13551 394503001884 Homeodomain-like domain; Region: HTH_32; pfam13565 394503001885 Integrase core domain; Region: rve; pfam00665 394503001886 Integrase core domain; Region: rve_3; pfam13683 394503001887 GTP-binding protein YchF; Reviewed; Region: PRK09601 394503001888 YchF GTPase; Region: YchF; cd01900 394503001889 G1 box; other site 394503001890 GTP/Mg2+ binding site [chemical binding]; other site 394503001891 Switch I region; other site 394503001892 G2 box; other site 394503001893 Switch II region; other site 394503001894 G3 box; other site 394503001895 G4 box; other site 394503001896 G5 box; other site 394503001897 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 394503001898 Double zinc ribbon; Region: DZR; pfam12773 394503001899 TM2 domain; Region: TM2; pfam05154 394503001900 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 394503001901 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 394503001902 DNA binding residues [nucleotide binding] 394503001903 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 394503001904 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 394503001905 active site 394503001906 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 394503001907 Aluminium resistance protein; Region: Alum_res; pfam06838 394503001908 HlyD family secretion protein; Region: HlyD_2; pfam12700 394503001909 putative membrane fusion protein; Region: TIGR02828 394503001910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 394503001911 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503001912 catalytic residue [active] 394503001913 Protein of unknown function (DUF552); Region: DUF552; pfam04472 394503001914 YGGT family; Region: YGGT; pfam02325 394503001915 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 394503001916 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503001917 RNA binding surface [nucleotide binding]; other site 394503001918 DivIVA protein; Region: DivIVA; pfam05103 394503001919 DivIVA domain; Region: DivI1A_domain; TIGR03544 394503001920 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 394503001921 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 394503001922 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 394503001923 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 394503001924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001925 binding surface 394503001926 TPR repeat; Region: TPR_11; pfam13414 394503001927 TPR motif; other site 394503001928 TPR repeat; Region: TPR_11; pfam13414 394503001929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001930 TPR motif; other site 394503001931 TPR repeat; Region: TPR_11; pfam13414 394503001932 binding surface 394503001933 TPR repeat; Region: TPR_11; pfam13414 394503001934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001935 binding surface 394503001936 TPR motif; other site 394503001937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001938 binding surface 394503001939 TPR repeat; Region: TPR_11; pfam13414 394503001940 TPR motif; other site 394503001941 Tetratricopeptide repeat; Region: TPR_16; pfam13432 394503001942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503001943 binding surface 394503001944 TPR motif; other site 394503001945 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 394503001946 hypothetical protein; Provisional; Region: PRK00955 394503001947 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 394503001948 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 394503001949 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 394503001950 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 394503001951 homodimer interface [polypeptide binding]; other site 394503001952 NADP binding site [chemical binding]; other site 394503001953 substrate binding site [chemical binding]; other site 394503001954 phosphodiesterase; Provisional; Region: PRK12704 394503001955 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 394503001956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503001957 Zn2+ binding site [ion binding]; other site 394503001958 Mg2+ binding site [ion binding]; other site 394503001959 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 394503001960 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503001961 putative active site [active] 394503001962 metal binding site [ion binding]; metal-binding site 394503001963 homodimer binding site [polypeptide binding]; other site 394503001964 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 394503001965 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 394503001966 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 394503001967 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 394503001968 peptide binding site [polypeptide binding]; other site 394503001969 dimer interface [polypeptide binding]; other site 394503001970 lipoprotein signal peptidase; Provisional; Region: PRK14787 394503001971 lipoprotein signal peptidase; Provisional; Region: PRK14791 394503001972 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 394503001973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503001974 RNA binding surface [nucleotide binding]; other site 394503001975 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 394503001976 active site 394503001977 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 394503001978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503001979 active site 394503001980 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 394503001981 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 394503001982 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 394503001983 dihydroorotase; Validated; Region: pyrC; PRK09357 394503001984 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 394503001985 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 394503001986 active site 394503001987 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 394503001988 active site 394503001989 dimer interface [polypeptide binding]; other site 394503001990 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 394503001991 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 394503001992 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 394503001993 catalytic site [active] 394503001994 subunit interface [polypeptide binding]; other site 394503001995 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 394503001996 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503001997 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 394503001998 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 394503001999 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503002000 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503002001 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 394503002002 IMP binding site; other site 394503002003 dimer interface [polypeptide binding]; other site 394503002004 interdomain contacts; other site 394503002005 partial ornithine binding site; other site 394503002006 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 394503002007 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 394503002008 FAD binding pocket [chemical binding]; other site 394503002009 FAD binding motif [chemical binding]; other site 394503002010 phosphate binding motif [ion binding]; other site 394503002011 beta-alpha-beta structure motif; other site 394503002012 NAD binding pocket [chemical binding]; other site 394503002013 Iron coordination center [ion binding]; other site 394503002014 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 394503002015 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 394503002016 heterodimer interface [polypeptide binding]; other site 394503002017 active site 394503002018 FMN binding site [chemical binding]; other site 394503002019 homodimer interface [polypeptide binding]; other site 394503002020 substrate binding site [chemical binding]; other site 394503002021 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 394503002022 catalytic core [active] 394503002023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503002024 active site 394503002025 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 394503002026 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 394503002027 putative deacylase active site [active] 394503002028 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 394503002029 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 394503002030 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 394503002031 YibE/F-like protein; Region: YibE_F; pfam07907 394503002032 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 394503002033 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 394503002034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 394503002035 metal binding site [ion binding]; metal-binding site 394503002036 active site 394503002037 I-site; other site 394503002038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 394503002039 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 394503002040 DNA binding residues [nucleotide binding] 394503002041 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 394503002042 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 394503002043 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 394503002044 Predicted membrane protein [Function unknown]; Region: COG2855 394503002045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 394503002046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 394503002047 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 394503002048 putative dimerization interface [polypeptide binding]; other site 394503002049 4Fe-4S binding domain; Region: Fer4_5; pfam12801 394503002050 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 394503002051 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503002052 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 394503002053 Protease prsW family; Region: PrsW-protease; pfam13367 394503002054 Flavodoxin domain; Region: Flavodoxin_5; cl17428 394503002055 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 394503002056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 394503002057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503002058 catalytic residue [active] 394503002059 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 394503002060 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 394503002061 classical (c) SDRs; Region: SDR_c; cd05233 394503002062 NAD(P) binding site [chemical binding]; other site 394503002063 active site 394503002064 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 394503002065 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 394503002066 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 394503002067 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 394503002068 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 394503002069 Glyco_18 domain; Region: Glyco_18; smart00636 394503002070 active site 394503002071 S-layer homology domain; Region: SLH; pfam00395 394503002072 S-layer homology domain; Region: SLH; pfam00395 394503002073 S-layer homology domain; Region: SLH; pfam00395 394503002074 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 394503002075 homotrimer interface [polypeptide binding]; other site 394503002076 Walker A motif; other site 394503002077 GTP binding site [chemical binding]; other site 394503002078 Walker B motif; other site 394503002079 cobalamin synthase; Reviewed; Region: cobS; PRK00235 394503002080 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 394503002081 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 394503002082 putative dimer interface [polypeptide binding]; other site 394503002083 active site pocket [active] 394503002084 putative cataytic base [active] 394503002085 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 394503002086 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503002087 Interdomain contacts; other site 394503002088 Cytokine receptor motif; other site 394503002089 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503002090 Interdomain contacts; other site 394503002091 Cytokine receptor motif; other site 394503002092 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 394503002093 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 394503002094 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002095 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503002097 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503002098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503002099 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503002100 Spore germination protein; Region: Spore_permease; cl17796 394503002101 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 394503002102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 394503002103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503002104 Coenzyme A binding pocket [chemical binding]; other site 394503002105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 394503002106 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 394503002107 DEAD/DEAH box helicase; Region: DEAD; pfam00270 394503002108 DEAD_2; Region: DEAD_2; pfam06733 394503002109 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 394503002110 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 394503002111 Part of AAA domain; Region: AAA_19; pfam13245 394503002112 Family description; Region: UvrD_C_2; pfam13538 394503002113 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 394503002114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503002115 motif II; other site 394503002116 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 394503002117 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 394503002118 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 394503002119 shikimate binding site; other site 394503002120 NAD(P) binding site [chemical binding]; other site 394503002121 Late competence development protein ComFB; Region: ComFB; pfam10719 394503002122 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 394503002123 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 394503002124 Transcriptional regulator [Transcription]; Region: LytR; COG1316 394503002125 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 394503002126 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 394503002127 dimer interface [polypeptide binding]; other site 394503002128 PYR/PP interface [polypeptide binding]; other site 394503002129 TPP binding site [chemical binding]; other site 394503002130 substrate binding site [chemical binding]; other site 394503002131 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 394503002132 TPP-binding site; other site 394503002133 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 394503002134 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 394503002135 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 394503002136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503002137 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 394503002138 acyl-activating enzyme (AAE) consensus motif; other site 394503002139 AMP binding site [chemical binding]; other site 394503002140 active site 394503002141 CoA binding site [chemical binding]; other site 394503002142 ACT domain-containing protein [General function prediction only]; Region: COG4747 394503002143 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 394503002144 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 394503002145 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 394503002146 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 394503002147 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 394503002148 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 394503002149 putative NAD(P) binding site [chemical binding]; other site 394503002150 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 394503002151 active site 394503002152 competence damage-inducible protein A; Provisional; Region: PRK00549 394503002153 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 394503002154 putative MPT binding site; other site 394503002155 Competence-damaged protein; Region: CinA; pfam02464 394503002156 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 394503002157 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 394503002158 recombinase A; Provisional; Region: recA; PRK09354 394503002159 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 394503002160 hexamer interface [polypeptide binding]; other site 394503002161 Walker A motif; other site 394503002162 ATP binding site [chemical binding]; other site 394503002163 Walker B motif; other site 394503002164 recombination regulator RecX; Reviewed; Region: recX; PRK00117 394503002165 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 394503002166 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 394503002167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503002168 FeS/SAM binding site; other site 394503002169 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 394503002170 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 394503002171 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 394503002172 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 394503002173 active site 2 [active] 394503002174 active site 1 [active] 394503002175 putative phosphate acyltransferase; Provisional; Region: PRK05331 394503002176 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 394503002177 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 394503002178 dimer interface [polypeptide binding]; other site 394503002179 active site 394503002180 CoA binding pocket [chemical binding]; other site 394503002181 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 394503002182 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503002183 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 394503002184 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 394503002185 NAD(P) binding site [chemical binding]; other site 394503002186 homotetramer interface [polypeptide binding]; other site 394503002187 homodimer interface [polypeptide binding]; other site 394503002188 active site 394503002189 acyl carrier protein; Provisional; Region: acpP; PRK00982 394503002190 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 394503002191 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 394503002192 dimer interface [polypeptide binding]; other site 394503002193 active site 394503002194 ribonuclease III; Reviewed; Region: rnc; PRK00102 394503002195 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 394503002196 dimerization interface [polypeptide binding]; other site 394503002197 active site 394503002198 metal binding site [ion binding]; metal-binding site 394503002199 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 394503002200 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503002201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503002202 FeS/SAM binding site; other site 394503002203 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 394503002204 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 394503002205 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 394503002206 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 394503002207 Coat F domain; Region: Coat_F; pfam07875 394503002208 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 394503002209 FMN binding site [chemical binding]; other site 394503002210 dimer interface [polypeptide binding]; other site 394503002211 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 394503002212 dimer interface [polypeptide binding]; other site 394503002213 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 394503002214 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503002215 active site 394503002216 catalytic tetrad [active] 394503002217 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503002218 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 394503002219 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 394503002220 Walker A/P-loop; other site 394503002221 ATP binding site [chemical binding]; other site 394503002222 Q-loop/lid; other site 394503002223 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 394503002224 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 394503002225 Q-loop/lid; other site 394503002226 ABC transporter signature motif; other site 394503002227 Walker B; other site 394503002228 D-loop; other site 394503002229 H-loop/switch region; other site 394503002230 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 394503002231 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 394503002232 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 394503002233 GTP binding site [chemical binding]; other site 394503002234 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 394503002235 Uncharacterized conserved protein [Function unknown]; Region: COG1615 394503002236 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 394503002237 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 394503002238 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 394503002239 nucleotide binding site [chemical binding]; other site 394503002240 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 394503002241 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 394503002242 ATP cone domain; Region: ATP-cone; pfam03477 394503002243 Class III ribonucleotide reductase; Region: RNR_III; cd01675 394503002244 effector binding site; other site 394503002245 active site 394503002246 Zn binding site [ion binding]; other site 394503002247 glycine loop; other site 394503002248 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 394503002249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503002250 FeS/SAM binding site; other site 394503002251 Sulfatase; Region: Sulfatase; cl17466 394503002252 pantothenate kinase; Provisional; Region: PRK13317 394503002253 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 394503002254 OPT oligopeptide transporter protein; Region: OPT; cl14607 394503002255 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 394503002256 putative metal binding site [ion binding]; other site 394503002257 Uncharacterized conserved protein [Function unknown]; Region: COG1432 394503002258 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 394503002259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503002260 DNA binding residues [nucleotide binding] 394503002261 signal recognition particle protein; Provisional; Region: PRK10867 394503002262 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 394503002263 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 394503002264 P loop; other site 394503002265 GTP binding site [chemical binding]; other site 394503002266 Signal peptide binding domain; Region: SRP_SPB; pfam02978 394503002267 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 394503002268 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 394503002269 hypothetical protein; Provisional; Region: PRK00468 394503002270 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 394503002271 RimM N-terminal domain; Region: RimM; pfam01782 394503002272 PRC-barrel domain; Region: PRC; pfam05239 394503002273 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 394503002274 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 394503002275 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 394503002276 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 394503002277 Catalytic site [active] 394503002278 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 394503002279 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 394503002280 GTP/Mg2+ binding site [chemical binding]; other site 394503002281 G4 box; other site 394503002282 G5 box; other site 394503002283 G1 box; other site 394503002284 Switch I region; other site 394503002285 G2 box; other site 394503002286 G3 box; other site 394503002287 Switch II region; other site 394503002288 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 394503002289 RNA/DNA hybrid binding site [nucleotide binding]; other site 394503002290 active site 394503002291 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 394503002292 hypothetical protein; Reviewed; Region: PRK12497 394503002293 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 394503002294 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 394503002295 active site 394503002296 dimer interface [polypeptide binding]; other site 394503002297 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 394503002298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503002299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503002300 homodimer interface [polypeptide binding]; other site 394503002301 catalytic residue [active] 394503002302 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 394503002303 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 394503002304 tetramer interface [polypeptide binding]; other site 394503002305 active site 394503002306 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 394503002307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503002308 DNA-binding site [nucleotide binding]; DNA binding site 394503002309 UTRA domain; Region: UTRA; pfam07702 394503002310 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 394503002311 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 394503002312 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 394503002313 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 394503002314 Cellulose binding domain; Region: CBM_3; pfam00942 394503002315 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 394503002316 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002317 dockerin binding interface; other site 394503002318 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002319 dockerin binding interface; other site 394503002320 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002321 dockerin binding interface; other site 394503002322 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002323 dockerin binding interface; other site 394503002324 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002325 dockerin binding interface; other site 394503002326 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002327 dockerin binding interface; other site 394503002328 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002329 dockerin binding interface; other site 394503002330 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 394503002331 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002332 dockerin binding interface; other site 394503002333 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 394503002334 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002335 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002336 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 394503002337 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002338 endoglucanase; Region: PLN02308 394503002339 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503002340 Cellulose binding domain; Region: CBM_3; pfam00942 394503002341 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002342 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002343 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503002344 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 394503002345 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503002346 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002347 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 394503002348 dockerin binding interface; other site 394503002349 endoglucanase; Region: PLN02171 394503002350 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503002351 Cellulose binding domain; Region: CBM_3; smart01067 394503002352 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002353 endoglucanase; Region: PLN02420 394503002354 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503002355 Cellulose binding domain; Region: CBM_3; smart01067 394503002356 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002357 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002358 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 394503002359 endoglucanase; Region: PLN02420 394503002360 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503002361 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002362 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002363 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 394503002364 metal binding site [ion binding]; metal-binding site 394503002365 active site 394503002366 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002367 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503002368 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 394503002369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 394503002370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 394503002371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 394503002372 dimerization interface [polypeptide binding]; other site 394503002373 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 394503002374 active site 394503002375 catalytic triad [active] 394503002376 oxyanion hole [active] 394503002377 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503002378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503002379 active site 394503002380 metal binding site [ion binding]; metal-binding site 394503002381 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 394503002382 putative active site [active] 394503002383 putative metal binding site [ion binding]; other site 394503002384 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 394503002385 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 394503002386 metal-binding site [ion binding] 394503002387 Family description; Region: DsbD_2; pfam13386 394503002388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 394503002389 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 394503002390 metal-binding site [ion binding] 394503002391 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 394503002392 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 394503002393 metal-binding site [ion binding] 394503002394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 394503002395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503002396 motif II; other site 394503002397 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503002398 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503002399 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503002400 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503002401 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503002402 hybrid cluster protein; Provisional; Region: PRK05290 394503002403 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503002404 ACS interaction site; other site 394503002405 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503002406 ACS interaction site; other site 394503002407 CODH interaction site; other site 394503002408 metal cluster binding site [ion binding]; other site 394503002409 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 394503002410 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002411 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002412 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 394503002413 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 394503002414 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 394503002415 putative metal binding site [ion binding]; other site 394503002416 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 394503002417 endoglucanase; Region: PLN02420 394503002418 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503002419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503002420 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503002421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503002422 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503002423 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 394503002424 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503002425 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002426 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002427 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 394503002428 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 394503002429 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 394503002430 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 394503002431 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 394503002432 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 394503002433 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 394503002434 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 394503002435 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 394503002436 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 394503002437 putative translocon binding site; other site 394503002438 protein-rRNA interface [nucleotide binding]; other site 394503002439 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 394503002440 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 394503002441 G-X-X-G motif; other site 394503002442 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 394503002443 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 394503002444 23S rRNA interface [nucleotide binding]; other site 394503002445 5S rRNA interface [nucleotide binding]; other site 394503002446 putative antibiotic binding site [chemical binding]; other site 394503002447 L25 interface [polypeptide binding]; other site 394503002448 L27 interface [polypeptide binding]; other site 394503002449 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 394503002450 23S rRNA interface [nucleotide binding]; other site 394503002451 putative translocon interaction site; other site 394503002452 signal recognition particle (SRP54) interaction site; other site 394503002453 L23 interface [polypeptide binding]; other site 394503002454 trigger factor interaction site; other site 394503002455 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 394503002456 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 394503002457 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 394503002458 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 394503002459 RNA binding site [nucleotide binding]; other site 394503002460 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 394503002461 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 394503002462 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 394503002463 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 394503002464 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 394503002465 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 394503002466 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 394503002467 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 394503002468 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 394503002469 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 394503002470 5S rRNA interface [nucleotide binding]; other site 394503002471 L27 interface [polypeptide binding]; other site 394503002472 23S rRNA interface [nucleotide binding]; other site 394503002473 L5 interface [polypeptide binding]; other site 394503002474 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 394503002475 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 394503002476 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 394503002477 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 394503002478 23S rRNA binding site [nucleotide binding]; other site 394503002479 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 394503002480 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 394503002481 SecY translocase; Region: SecY; pfam00344 394503002482 adenylate kinase; Reviewed; Region: adk; PRK00279 394503002483 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 394503002484 AMP-binding site [chemical binding]; other site 394503002485 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 394503002486 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 394503002487 active site 394503002488 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 394503002489 RNA binding site [nucleotide binding]; other site 394503002490 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 394503002491 rRNA binding site [nucleotide binding]; other site 394503002492 predicted 30S ribosome binding site; other site 394503002493 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 394503002494 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 394503002495 30S ribosomal protein S13; Region: bact_S13; TIGR03631 394503002496 30S ribosomal protein S11; Validated; Region: PRK05309 394503002497 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 394503002498 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 394503002499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503002500 RNA binding surface [nucleotide binding]; other site 394503002501 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 394503002502 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 394503002503 alphaNTD homodimer interface [polypeptide binding]; other site 394503002504 alphaNTD - beta interaction site [polypeptide binding]; other site 394503002505 alphaNTD - beta' interaction site [polypeptide binding]; other site 394503002506 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 394503002507 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 394503002508 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 394503002509 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 394503002510 Walker A/P-loop; other site 394503002511 ATP binding site [chemical binding]; other site 394503002512 Q-loop/lid; other site 394503002513 ABC transporter signature motif; other site 394503002514 Walker B; other site 394503002515 D-loop; other site 394503002516 H-loop/switch region; other site 394503002517 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 394503002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503002519 S-adenosylmethionine binding site [chemical binding]; other site 394503002520 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 394503002521 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 394503002522 Walker A/P-loop; other site 394503002523 ATP binding site [chemical binding]; other site 394503002524 Q-loop/lid; other site 394503002525 ABC transporter signature motif; other site 394503002526 Walker B; other site 394503002527 D-loop; other site 394503002528 H-loop/switch region; other site 394503002529 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 394503002530 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 394503002531 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 394503002532 dimerization interface 3.5A [polypeptide binding]; other site 394503002533 active site 394503002534 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 394503002535 23S rRNA interface [nucleotide binding]; other site 394503002536 L3 interface [polypeptide binding]; other site 394503002537 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 394503002538 manganese transport protein MntH; Reviewed; Region: PRK00701 394503002539 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 394503002540 manganese transport transcriptional regulator; Provisional; Region: PRK03902 394503002541 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 394503002542 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 394503002543 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 394503002544 active site 394503002545 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 394503002546 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 394503002547 Glycoprotease family; Region: Peptidase_M22; pfam00814 394503002548 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 394503002549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503002550 Coenzyme A binding pocket [chemical binding]; other site 394503002551 AAA domain; Region: AAA_32; pfam13654 394503002552 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 394503002553 RNA helicase; Region: RNA_helicase; pfam00910 394503002554 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 394503002555 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 394503002556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503002557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503002558 DNA binding residues [nucleotide binding] 394503002559 Putative zinc-finger; Region: zf-HC2; pfam13490 394503002560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 394503002561 dimerization domain swap beta strand [polypeptide binding]; other site 394503002562 regulatory protein interface [polypeptide binding]; other site 394503002563 active site 394503002564 regulatory phosphorylation site [posttranslational modification]; other site 394503002565 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 394503002566 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 394503002567 GIY-YIG motif/motif A; other site 394503002568 active site 394503002569 catalytic site [active] 394503002570 putative DNA binding site [nucleotide binding]; other site 394503002571 metal binding site [ion binding]; metal-binding site 394503002572 UvrB/uvrC motif; Region: UVR; pfam02151 394503002573 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 394503002574 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 394503002575 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503002576 active site 394503002577 metal binding site [ion binding]; metal-binding site 394503002578 trigger factor; Provisional; Region: tig; PRK01490 394503002579 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 394503002580 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 394503002581 Clp protease; Region: CLP_protease; pfam00574 394503002582 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 394503002583 oligomer interface [polypeptide binding]; other site 394503002584 active site residues [active] 394503002585 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 394503002586 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 394503002587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503002588 Walker A motif; other site 394503002589 ATP binding site [chemical binding]; other site 394503002590 Walker B motif; other site 394503002591 arginine finger; other site 394503002592 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 394503002593 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 394503002594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503002595 Walker A motif; other site 394503002596 ATP binding site [chemical binding]; other site 394503002597 Walker B motif; other site 394503002598 arginine finger; other site 394503002599 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 394503002600 Bacteriophage holin; Region: Phage_holin_1; cl02344 394503002601 UGMP family protein; Validated; Region: PRK09604 394503002602 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 394503002603 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 394503002604 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 394503002605 N-acetyl-D-glucosamine binding site [chemical binding]; other site 394503002606 catalytic residue [active] 394503002607 Protein of unknown function (DUF402); Region: DUF402; pfam04167 394503002608 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 394503002609 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 394503002610 active site 394503002611 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 394503002612 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 394503002613 SmpB-tmRNA interface; other site 394503002614 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 394503002615 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 394503002616 Int/Topo IB signature motif; other site 394503002617 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503002618 Winged helix-turn helix; Region: HTH_29; pfam13551 394503002619 Homeodomain-like domain; Region: HTH_32; pfam13565 394503002620 Integrase core domain; Region: rve; pfam00665 394503002621 Integrase core domain; Region: rve_3; pfam13683 394503002622 Transposase; Region: HTH_Tnp_1; pfam01527 394503002623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503002624 putative transposase OrfB; Reviewed; Region: PHA02517 394503002625 HTH-like domain; Region: HTH_21; pfam13276 394503002626 Integrase core domain; Region: rve; pfam00665 394503002627 Integrase core domain; Region: rve_3; pfam13683 394503002628 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503002629 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 394503002630 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503002631 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 394503002632 Transposase; Region: HTH_Tnp_1; pfam01527 394503002633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503002634 putative transposase OrfB; Reviewed; Region: PHA02517 394503002635 HTH-like domain; Region: HTH_21; pfam13276 394503002636 Integrase core domain; Region: rve; pfam00665 394503002637 Integrase core domain; Region: rve_3; pfam13683 394503002638 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 394503002639 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503002640 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 394503002641 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503002643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503002644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503002645 Transposase; Region: HTH_Tnp_1; pfam01527 394503002646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503002647 putative transposase OrfB; Reviewed; Region: PHA02517 394503002648 HTH-like domain; Region: HTH_21; pfam13276 394503002649 Integrase core domain; Region: rve; pfam00665 394503002650 Integrase core domain; Region: rve_3; pfam13683 394503002651 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 394503002652 active site clefts [active] 394503002653 zinc binding site [ion binding]; other site 394503002654 dimer interface [polypeptide binding]; other site 394503002655 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503002656 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503002657 catalytic residues [active] 394503002658 Recombinase; Region: Recombinase; pfam07508 394503002659 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 394503002660 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 394503002661 heterodimer interface [polypeptide binding]; other site 394503002662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 394503002663 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503002664 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 394503002665 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 394503002666 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503002667 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 394503002668 FMN binding site [chemical binding]; other site 394503002669 substrate binding site [chemical binding]; other site 394503002670 putative catalytic residue [active] 394503002671 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503002672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503002673 Walker A/P-loop; other site 394503002674 ATP binding site [chemical binding]; other site 394503002675 Q-loop/lid; other site 394503002676 ABC transporter signature motif; other site 394503002677 Walker B; other site 394503002678 D-loop; other site 394503002679 H-loop/switch region; other site 394503002680 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 394503002681 FtsX-like permease family; Region: FtsX; pfam02687 394503002682 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 394503002683 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 394503002684 FtsX-like permease family; Region: FtsX; pfam02687 394503002685 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002686 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002687 active site 394503002688 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002689 putative NADP binding site [chemical binding]; other site 394503002690 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002691 active site 394503002692 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002693 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002694 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002695 active site 394503002696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002697 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002698 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002699 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002700 putative NADP binding site [chemical binding]; other site 394503002701 active site 394503002702 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002703 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002704 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002705 active site 394503002706 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002707 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002708 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002709 putative NADP binding site [chemical binding]; other site 394503002710 active site 394503002711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002712 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002713 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002714 active site 394503002715 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002716 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002717 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002718 putative NADP binding site [chemical binding]; other site 394503002719 active site 394503002720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002721 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002722 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002723 active site 394503002724 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002725 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002726 putative NADP binding site [chemical binding]; other site 394503002727 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002728 active site 394503002729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002730 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002731 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002732 active site 394503002733 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002734 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002735 putative NADP binding site [chemical binding]; other site 394503002736 KR domain; Region: KR; pfam08659 394503002737 active site 394503002738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002739 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002740 active site 394503002741 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002742 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002743 KR domain; Region: KR; pfam08659 394503002744 putative NADP binding site [chemical binding]; other site 394503002745 active site 394503002746 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002748 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002749 active site 394503002750 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002751 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002752 putative NADP binding site [chemical binding]; other site 394503002753 active site 394503002754 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002755 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002756 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002757 active site 394503002758 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002759 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002760 putative NADP binding site [chemical binding]; other site 394503002761 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002762 active site 394503002763 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002764 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002765 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002766 active site 394503002767 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002768 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002769 putative NADP binding site [chemical binding]; other site 394503002770 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002771 active site 394503002772 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002774 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002775 active site 394503002776 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 394503002777 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002778 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002779 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002780 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002781 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002782 active site 394503002783 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503002784 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503002785 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503002786 putative NADP binding site [chemical binding]; other site 394503002787 active site 394503002788 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 394503002789 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002790 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002791 active site 394503002792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002793 Condensation domain; Region: Condensation; pfam00668 394503002794 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503002795 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503002796 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 394503002797 acyl-activating enzyme (AAE) consensus motif; other site 394503002798 AMP binding site [chemical binding]; other site 394503002799 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503002800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503002801 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503002802 active site 394503002803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 394503002804 acyl carrier protein; Provisional; Region: acpP; PRK00982 394503002805 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 394503002806 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 394503002807 dimer interface [polypeptide binding]; other site 394503002808 active site 394503002809 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 394503002810 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 394503002811 active site 394503002812 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 394503002813 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 394503002814 dimer interface [polypeptide binding]; other site 394503002815 active site 394503002816 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 394503002817 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 394503002818 classical (c) SDRs; Region: SDR_c; cd05233 394503002819 NAD(P) binding site [chemical binding]; other site 394503002820 active site 394503002821 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 394503002822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503002823 FeS/SAM binding site; other site 394503002824 HemN C-terminal domain; Region: HemN_C; pfam06969 394503002825 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 394503002826 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 394503002827 active site 394503002828 SCP-2 sterol transfer family; Region: SCP2; cl01225 394503002829 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 394503002830 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 394503002831 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 394503002832 ATP binding site [chemical binding]; other site 394503002833 substrate interface [chemical binding]; other site 394503002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503002835 putative substrate translocation pore; other site 394503002836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 394503002837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 394503002838 NMT1-like family; Region: NMT1_2; pfam13379 394503002839 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 394503002840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503002841 dimer interface [polypeptide binding]; other site 394503002842 conserved gate region; other site 394503002843 putative PBP binding loops; other site 394503002844 ABC-ATPase subunit interface; other site 394503002845 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 394503002846 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 394503002847 Walker A/P-loop; other site 394503002848 ATP binding site [chemical binding]; other site 394503002849 Q-loop/lid; other site 394503002850 ABC transporter signature motif; other site 394503002851 Walker B; other site 394503002852 D-loop; other site 394503002853 H-loop/switch region; other site 394503002854 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503002855 Peptidase M60-like family; Region: M60-like; pfam13402 394503002856 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 394503002857 putative active site [active] 394503002858 putative metal binding site [ion binding]; other site 394503002859 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 394503002860 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503002861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 394503002862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 394503002863 substrate binding pocket [chemical binding]; other site 394503002864 membrane-bound complex binding site; other site 394503002865 hinge residues; other site 394503002866 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 394503002867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503002868 dimer interface [polypeptide binding]; other site 394503002869 conserved gate region; other site 394503002870 putative PBP binding loops; other site 394503002871 ABC-ATPase subunit interface; other site 394503002872 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 394503002873 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 394503002874 Walker A/P-loop; other site 394503002875 ATP binding site [chemical binding]; other site 394503002876 Q-loop/lid; other site 394503002877 ABC transporter signature motif; other site 394503002878 Walker B; other site 394503002879 D-loop; other site 394503002880 H-loop/switch region; other site 394503002881 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 394503002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503002883 non-specific DNA binding site [nucleotide binding]; other site 394503002884 salt bridge; other site 394503002885 sequence-specific DNA binding site [nucleotide binding]; other site 394503002886 Cupin domain; Region: Cupin_2; pfam07883 394503002887 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 394503002888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503002889 Walker A/P-loop; other site 394503002890 ATP binding site [chemical binding]; other site 394503002891 Q-loop/lid; other site 394503002892 ABC transporter signature motif; other site 394503002893 Walker B; other site 394503002894 D-loop; other site 394503002895 H-loop/switch region; other site 394503002896 TOBE domain; Region: TOBE_2; pfam08402 394503002897 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 394503002898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503002899 dimer interface [polypeptide binding]; other site 394503002900 conserved gate region; other site 394503002901 putative PBP binding loops; other site 394503002902 ABC-ATPase subunit interface; other site 394503002903 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 394503002904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503002905 dimer interface [polypeptide binding]; other site 394503002906 conserved gate region; other site 394503002907 putative PBP binding loops; other site 394503002908 ABC-ATPase subunit interface; other site 394503002909 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 394503002910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 394503002911 Rubrerythrin [Energy production and conversion]; Region: COG1592 394503002912 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 394503002913 binuclear metal center [ion binding]; other site 394503002914 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 394503002915 iron binding site [ion binding]; other site 394503002916 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 394503002917 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 394503002918 putative active site [active] 394503002919 metal binding site [ion binding]; metal-binding site 394503002920 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 394503002921 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 394503002922 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 394503002923 acyl-activating enzyme (AAE) consensus motif; other site 394503002924 putative AMP binding site [chemical binding]; other site 394503002925 putative active site [active] 394503002926 putative CoA binding site [chemical binding]; other site 394503002927 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 394503002928 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 394503002929 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 394503002930 G1 box; other site 394503002931 GTP/Mg2+ binding site [chemical binding]; other site 394503002932 Switch I region; other site 394503002933 G2 box; other site 394503002934 G3 box; other site 394503002935 Switch II region; other site 394503002936 G4 box; other site 394503002937 G5 box; other site 394503002938 Protein of unknown function (DUF445); Region: DUF445; pfam04286 394503002939 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 394503002940 Cation efflux family; Region: Cation_efflux; cl00316 394503002941 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503002942 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 394503002943 Rubredoxin; Region: Rubredoxin; pfam00301 394503002944 iron binding site [ion binding]; other site 394503002945 Rubrerythrin [Energy production and conversion]; Region: COG1592 394503002946 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 394503002947 diiron binding motif [ion binding]; other site 394503002948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503002949 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503002950 Transposase; Region: HTH_Tnp_1; cl17663 394503002951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503002952 HTH-like domain; Region: HTH_21; pfam13276 394503002953 Integrase core domain; Region: rve; pfam00665 394503002954 Integrase core domain; Region: rve_2; pfam13333 394503002955 Domain of unknown function (DUF362); Region: DUF362; pfam04015 394503002956 Predicted permeases [General function prediction only]; Region: COG0701 394503002957 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 394503002958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503002959 putative substrate translocation pore; other site 394503002960 cytosine deaminase; Provisional; Region: PRK09230 394503002961 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 394503002962 active site 394503002963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 394503002964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503002965 NAD(P) binding site [chemical binding]; other site 394503002966 active site 394503002967 CAAX protease self-immunity; Region: Abi; pfam02517 394503002968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503002969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503002970 active site 394503002971 phosphorylation site [posttranslational modification] 394503002972 intermolecular recognition site; other site 394503002973 dimerization interface [polypeptide binding]; other site 394503002974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503002975 DNA binding site [nucleotide binding] 394503002976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503002977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503002978 dimerization interface [polypeptide binding]; other site 394503002979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503002980 dimer interface [polypeptide binding]; other site 394503002981 phosphorylation site [posttranslational modification] 394503002982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503002983 ATP binding site [chemical binding]; other site 394503002984 Mg2+ binding site [ion binding]; other site 394503002985 G-X-G motif; other site 394503002986 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503002987 Winged helix-turn helix; Region: HTH_29; pfam13551 394503002988 Homeodomain-like domain; Region: HTH_32; pfam13565 394503002989 Integrase core domain; Region: rve; pfam00665 394503002990 Integrase core domain; Region: rve_3; pfam13683 394503002991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 394503002992 Putative esterase; Region: Esterase; pfam00756 394503002993 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002994 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503002995 DNA topoisomerase III; Provisional; Region: PRK07726 394503002996 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 394503002997 active site 394503002998 putative interdomain interaction site [polypeptide binding]; other site 394503002999 putative metal-binding site [ion binding]; other site 394503003000 putative nucleotide binding site [chemical binding]; other site 394503003001 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 394503003002 domain I; other site 394503003003 DNA binding groove [nucleotide binding] 394503003004 phosphate binding site [ion binding]; other site 394503003005 domain II; other site 394503003006 domain III; other site 394503003007 nucleotide binding site [chemical binding]; other site 394503003008 catalytic site [active] 394503003009 domain IV; other site 394503003010 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 394503003011 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 394503003012 Ligand Binding Site [chemical binding]; other site 394503003013 Predicted transcriptional regulator [Transcription]; Region: COG1959 394503003014 Transcriptional regulator; Region: Rrf2; cl17282 394503003015 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 394503003016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503003017 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 394503003018 DNA binding residues [nucleotide binding] 394503003019 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 394503003020 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 394503003021 active site 394503003022 dimer interface [polypeptide binding]; other site 394503003023 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 394503003024 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 394503003025 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003026 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003027 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 394503003028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503003029 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503003030 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 394503003031 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 394503003032 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 394503003033 carboxyltransferase (CT) interaction site; other site 394503003034 biotinylation site [posttranslational modification]; other site 394503003035 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 394503003036 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503003037 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503003038 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 394503003039 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 394503003040 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 394503003041 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 394503003042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 394503003043 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 394503003044 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 394503003045 DNA interaction; other site 394503003046 Metal-binding active site; metal-binding site 394503003047 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503003048 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503003049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003050 Response regulator receiver domain; Region: Response_reg; pfam00072 394503003051 active site 394503003052 phosphorylation site [posttranslational modification] 394503003053 intermolecular recognition site; other site 394503003054 dimerization interface [polypeptide binding]; other site 394503003055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003057 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 394503003058 Histidine kinase; Region: His_kinase; pfam06580 394503003059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503003060 ATP binding site [chemical binding]; other site 394503003061 Mg2+ binding site [ion binding]; other site 394503003062 G-X-G motif; other site 394503003063 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503003064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003065 dimer interface [polypeptide binding]; other site 394503003066 conserved gate region; other site 394503003067 putative PBP binding loops; other site 394503003068 ABC-ATPase subunit interface; other site 394503003069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503003070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003071 dimer interface [polypeptide binding]; other site 394503003072 conserved gate region; other site 394503003073 putative PBP binding loops; other site 394503003074 ABC-ATPase subunit interface; other site 394503003075 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003077 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503003078 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 394503003079 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503003080 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503003081 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 394503003082 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 394503003083 putative NAD(P) binding site [chemical binding]; other site 394503003084 catalytic Zn binding site [ion binding]; other site 394503003085 structural Zn binding site [ion binding]; other site 394503003086 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 394503003087 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 394503003088 putative NAD(P) binding site [chemical binding]; other site 394503003089 catalytic Zn binding site [ion binding]; other site 394503003090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503003091 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 394503003092 putative substrate binding site [chemical binding]; other site 394503003093 putative ATP binding site [chemical binding]; other site 394503003094 Accessory gene regulator B; Region: AgrB; pfam04647 394503003095 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 394503003096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503003097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503003098 non-specific DNA binding site [nucleotide binding]; other site 394503003099 salt bridge; other site 394503003100 sequence-specific DNA binding site [nucleotide binding]; other site 394503003101 Methyltransferase domain; Region: Methyltransf_31; pfam13847 394503003102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503003103 S-adenosylmethionine binding site [chemical binding]; other site 394503003104 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503003105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003106 FeS/SAM binding site; other site 394503003107 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 394503003108 AAA ATPase domain; Region: AAA_16; pfam13191 394503003109 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 394503003110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503003111 ATP binding site [chemical binding]; other site 394503003112 putative Mg++ binding site [ion binding]; other site 394503003113 nucleotide binding region [chemical binding]; other site 394503003114 helicase superfamily c-terminal domain; Region: HELICc; smart00490 394503003115 Condensation domain; Region: Condensation; pfam00668 394503003116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003117 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503003118 acyl-activating enzyme (AAE) consensus motif; other site 394503003119 AMP binding site [chemical binding]; other site 394503003120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003121 Condensation domain; Region: Condensation; pfam00668 394503003122 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003123 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 394503003124 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503003125 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503003126 Walker A/P-loop; other site 394503003127 ATP binding site [chemical binding]; other site 394503003128 Q-loop/lid; other site 394503003129 ABC transporter signature motif; other site 394503003130 Walker B; other site 394503003131 D-loop; other site 394503003132 H-loop/switch region; other site 394503003133 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 394503003134 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 394503003135 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503003136 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 394503003137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503003138 NAD(P) binding site [chemical binding]; other site 394503003139 active site 394503003140 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 394503003141 active site 394503003142 Substrate binding site; other site 394503003143 Mg++ binding site; other site 394503003144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 394503003145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503003146 NAD(P) binding site [chemical binding]; other site 394503003147 active site 394503003148 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 394503003149 glycosyltransferase, MGT family; Region: MGT; TIGR01426 394503003150 active site 394503003151 TDP-binding site; other site 394503003152 acceptor substrate-binding pocket; other site 394503003153 homodimer interface [polypeptide binding]; other site 394503003154 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 394503003155 Beta-lactamase; Region: Beta-lactamase; pfam00144 394503003156 Condensation domain; Region: Condensation; pfam00668 394503003157 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503003159 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503003160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003161 FeS/SAM binding site; other site 394503003162 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 394503003163 B12 binding site [chemical binding]; other site 394503003164 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503003165 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 394503003166 acyl-activating enzyme (AAE) consensus motif; other site 394503003167 AMP binding site [chemical binding]; other site 394503003168 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 394503003169 Ligand Binding Site [chemical binding]; other site 394503003170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503003171 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003172 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 394503003173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503003174 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503003175 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503003176 active site 394503003177 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503003178 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503003179 putative NADP binding site [chemical binding]; other site 394503003180 active site 394503003181 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003182 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503003183 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503003184 active site 394503003185 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003186 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 394503003187 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503003188 inhibitor-cofactor binding pocket; inhibition site 394503003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503003190 catalytic residue [active] 394503003191 Condensation domain; Region: Condensation; pfam00668 394503003192 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003193 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503003194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503003195 acyl-activating enzyme (AAE) consensus motif; other site 394503003196 AMP binding site [chemical binding]; other site 394503003197 active site 394503003198 CoA binding site [chemical binding]; other site 394503003199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003200 Condensation domain; Region: Condensation; pfam00668 394503003201 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003202 Nonribosomal peptide synthase; Region: NRPS; pfam08415 394503003203 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 394503003204 acyl-activating enzyme (AAE) consensus motif; other site 394503003205 AMP binding site [chemical binding]; other site 394503003206 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 394503003207 putative FMN binding site [chemical binding]; other site 394503003208 NADPH bind site [chemical binding]; other site 394503003209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503003210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003211 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503003212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503003213 active site 394503003214 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503003215 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 394503003216 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503003217 putative NADP binding site [chemical binding]; other site 394503003218 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503003219 active site 394503003220 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503003221 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003222 Condensation domain; Region: Condensation; pfam00668 394503003223 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003224 Nonribosomal peptide synthase; Region: NRPS; pfam08415 394503003225 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 394503003226 acyl-activating enzyme (AAE) consensus motif; other site 394503003227 AMP binding site [chemical binding]; other site 394503003228 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003229 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 394503003230 putative FMN binding site [chemical binding]; other site 394503003231 NADPH bind site [chemical binding]; other site 394503003232 Condensation domain; Region: Condensation; pfam00668 394503003233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003234 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503003235 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503003236 acyl-activating enzyme (AAE) consensus motif; other site 394503003237 AMP binding site [chemical binding]; other site 394503003238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003239 Condensation domain; Region: Condensation; pfam00668 394503003240 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003241 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503003242 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503003243 acyl-activating enzyme (AAE) consensus motif; other site 394503003244 AMP binding site [chemical binding]; other site 394503003245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003246 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 394503003247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503003248 catalytic residue [active] 394503003249 Condensation domain; Region: Condensation; pfam00668 394503003250 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503003252 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503003253 acyl-activating enzyme (AAE) consensus motif; other site 394503003254 AMP binding site [chemical binding]; other site 394503003255 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003256 Condensation domain; Region: Condensation; pfam00668 394503003257 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003258 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 394503003259 Condensation domain; Region: Condensation; pfam00668 394503003260 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503003261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003262 Radical SAM superfamily; Region: Radical_SAM; pfam04055 394503003263 FeS/SAM binding site; other site 394503003264 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 394503003265 Ligand Binding Site [chemical binding]; other site 394503003266 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 394503003267 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 394503003268 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 394503003269 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 394503003270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 394503003271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 394503003272 active site 394503003273 FkbH-like domain; Region: FkbH; TIGR01686 394503003274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503003275 active site 394503003276 motif I; other site 394503003277 motif II; other site 394503003278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003279 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503003280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003283 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503003284 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 394503003285 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 394503003286 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 394503003287 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 394503003288 Ca binding site [ion binding]; other site 394503003289 carbohydrate binding site [chemical binding]; other site 394503003290 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503003291 Interdomain contacts; other site 394503003292 Cytokine receptor motif; other site 394503003293 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503003294 Interdomain contacts; other site 394503003295 Cytokine receptor motif; other site 394503003296 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503003297 Interdomain contacts; other site 394503003298 S-layer homology domain; Region: SLH; pfam00395 394503003299 S-layer homology domain; Region: SLH; pfam00395 394503003300 S-layer homology domain; Region: SLH; pfam00395 394503003301 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 394503003302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503003303 dimerization interface [polypeptide binding]; other site 394503003304 Histidine kinase; Region: His_kinase; pfam06580 394503003305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503003306 ATP binding site [chemical binding]; other site 394503003307 Mg2+ binding site [ion binding]; other site 394503003308 G-X-G motif; other site 394503003309 Response regulator receiver domain; Region: Response_reg; pfam00072 394503003310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003311 active site 394503003312 phosphorylation site [posttranslational modification] 394503003313 intermolecular recognition site; other site 394503003314 dimerization interface [polypeptide binding]; other site 394503003315 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003318 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 394503003320 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 394503003321 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003323 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003325 dimer interface [polypeptide binding]; other site 394503003326 conserved gate region; other site 394503003327 putative PBP binding loops; other site 394503003328 ABC-ATPase subunit interface; other site 394503003329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503003330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003331 dimer interface [polypeptide binding]; other site 394503003332 conserved gate region; other site 394503003333 putative PBP binding loops; other site 394503003334 ABC-ATPase subunit interface; other site 394503003335 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503003336 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 394503003337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003338 alpha-galactosidase; Provisional; Region: PRK15076 394503003339 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 394503003340 NAD binding site [chemical binding]; other site 394503003341 sugar binding site [chemical binding]; other site 394503003342 divalent metal binding site [ion binding]; other site 394503003343 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503003344 dimer interface [polypeptide binding]; other site 394503003345 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503003346 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 394503003347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003349 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 394503003350 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 394503003351 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 394503003352 putative active site [active] 394503003353 putative catalytic site [active] 394503003354 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503003355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 394503003356 DNA binding site [nucleotide binding] 394503003357 domain linker motif; other site 394503003358 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 394503003359 dimerization interface [polypeptide binding]; other site 394503003360 ligand binding site [chemical binding]; other site 394503003361 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 394503003362 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 394503003363 N- and C-terminal domain interface [polypeptide binding]; other site 394503003364 putative active site [active] 394503003365 MgATP binding site [chemical binding]; other site 394503003366 catalytic site [active] 394503003367 metal binding site [ion binding]; metal-binding site 394503003368 putative xylulose binding site [chemical binding]; other site 394503003369 putative homodimer interface [polypeptide binding]; other site 394503003370 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 394503003371 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 394503003372 putative NAD(P) binding site [chemical binding]; other site 394503003373 catalytic Zn binding site [ion binding]; other site 394503003374 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 394503003375 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503003376 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 394503003377 active site 394503003378 catalytic tetrad [active] 394503003379 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 394503003380 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 394503003381 substrate binding site [chemical binding]; other site 394503003382 active site 394503003383 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503003384 ligand binding site [chemical binding]; other site 394503003385 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 394503003386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003387 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 394503003388 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503003389 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 394503003390 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 394503003391 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 394503003392 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003394 dimer interface [polypeptide binding]; other site 394503003395 conserved gate region; other site 394503003396 ABC-ATPase subunit interface; other site 394503003397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503003398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003399 dimer interface [polypeptide binding]; other site 394503003400 conserved gate region; other site 394503003401 putative PBP binding loops; other site 394503003402 ABC-ATPase subunit interface; other site 394503003403 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003405 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 394503003406 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 394503003407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503003408 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503003409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503003410 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503003411 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 394503003412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503003413 putative substrate translocation pore; other site 394503003414 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 394503003415 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 394503003416 metal binding site [ion binding]; metal-binding site 394503003417 putative dimer interface [polypeptide binding]; other site 394503003418 Predicted membrane protein [Function unknown]; Region: COG2860 394503003419 UPF0126 domain; Region: UPF0126; pfam03458 394503003420 UPF0126 domain; Region: UPF0126; pfam03458 394503003421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003422 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003424 dimer interface [polypeptide binding]; other site 394503003425 conserved gate region; other site 394503003426 putative PBP binding loops; other site 394503003427 ABC-ATPase subunit interface; other site 394503003428 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503003429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003430 dimer interface [polypeptide binding]; other site 394503003431 conserved gate region; other site 394503003432 putative PBP binding loops; other site 394503003433 ABC-ATPase subunit interface; other site 394503003434 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 394503003435 intersubunit interface [polypeptide binding]; other site 394503003436 active site 394503003437 catalytic residue [active] 394503003438 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 394503003439 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 394503003440 putative NAD(P) binding site [chemical binding]; other site 394503003441 catalytic Zn binding site [ion binding]; other site 394503003442 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 394503003443 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 394503003444 putative NAD(P) binding site [chemical binding]; other site 394503003445 catalytic Zn binding site [ion binding]; other site 394503003446 glycerol kinase; Provisional; Region: glpK; PRK00047 394503003447 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 394503003448 N- and C-terminal domain interface [polypeptide binding]; other site 394503003449 active site 394503003450 MgATP binding site [chemical binding]; other site 394503003451 catalytic site [active] 394503003452 metal binding site [ion binding]; metal-binding site 394503003453 glycerol binding site [chemical binding]; other site 394503003454 homotetramer interface [polypeptide binding]; other site 394503003455 homodimer interface [polypeptide binding]; other site 394503003456 FBP binding site [chemical binding]; other site 394503003457 protein IIAGlc interface [polypeptide binding]; other site 394503003458 C factor cell-cell signaling protein; Provisional; Region: PRK09009 394503003459 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 394503003460 NADP binding site [chemical binding]; other site 394503003461 homodimer interface [polypeptide binding]; other site 394503003462 active site 394503003463 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 394503003464 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 394503003465 hexamer (dimer of trimers) interface [polypeptide binding]; other site 394503003466 trimer interface [polypeptide binding]; other site 394503003467 substrate binding site [chemical binding]; other site 394503003468 Mn binding site [ion binding]; other site 394503003469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503003470 DNA binding residues [nucleotide binding] 394503003471 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 394503003472 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 394503003473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 394503003474 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 394503003475 active site 394503003476 metal binding site [ion binding]; metal-binding site 394503003477 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 394503003478 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 394503003479 Flavin Reductases; Region: FlaRed; cl00801 394503003480 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 394503003481 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 394503003482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 394503003483 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 394503003484 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 394503003485 Soluble P-type ATPase [General function prediction only]; Region: COG4087 394503003486 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 394503003487 L-tyrosine decarboxylase; Provisional; Region: PRK13520 394503003488 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 394503003489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503003490 catalytic residue [active] 394503003491 Peptidase family U32; Region: Peptidase_U32; cl03113 394503003492 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 394503003493 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 394503003494 histidinol-phosphate aminotransferase; Provisional; Region: PRK14807 394503003495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503003496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503003497 homodimer interface [polypeptide binding]; other site 394503003498 catalytic residue [active] 394503003499 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 394503003500 Methyltransferase domain; Region: Methyltransf_23; pfam13489 394503003501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503003502 S-adenosylmethionine binding site [chemical binding]; other site 394503003503 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 394503003504 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503003505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003506 FeS/SAM binding site; other site 394503003507 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503003508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003509 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503003510 FeS/SAM binding site; other site 394503003511 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 394503003512 Chloramphenicol acetyltransferase; Region: CAT; smart01059 394503003513 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 394503003514 Part of AAA domain; Region: AAA_19; pfam13245 394503003515 Family description; Region: UvrD_C_2; pfam13538 394503003516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003519 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 394503003520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503003521 Coenzyme A binding pocket [chemical binding]; other site 394503003522 Methyltransferase domain; Region: Methyltransf_23; pfam13489 394503003523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503003524 S-adenosylmethionine binding site [chemical binding]; other site 394503003525 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 394503003526 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 394503003527 G1 box; other site 394503003528 putative GEF interaction site [polypeptide binding]; other site 394503003529 GTP/Mg2+ binding site [chemical binding]; other site 394503003530 Switch I region; other site 394503003531 G2 box; other site 394503003532 G3 box; other site 394503003533 Switch II region; other site 394503003534 G4 box; other site 394503003535 G5 box; other site 394503003536 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 394503003537 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 394503003538 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 394503003539 YacP-like NYN domain; Region: NYN_YacP; pfam05991 394503003540 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 394503003541 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 394503003542 FMN binding site [chemical binding]; other site 394503003543 active site 394503003544 catalytic residues [active] 394503003545 substrate binding site [chemical binding]; other site 394503003546 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 394503003547 putative FMN binding site [chemical binding]; other site 394503003548 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 394503003549 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 394503003550 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 394503003551 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 394503003552 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 394503003553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 394503003554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 394503003555 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 394503003556 active site 394503003557 catalytic triad [active] 394503003558 oxyanion hole [active] 394503003559 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003560 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503003562 dimerization interface [polypeptide binding]; other site 394503003563 putative DNA binding site [nucleotide binding]; other site 394503003564 putative Zn2+ binding site [ion binding]; other site 394503003565 Predicted permeases [General function prediction only]; Region: COG0701 394503003566 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 394503003567 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 394503003568 Low molecular weight phosphatase family; Region: LMWPc; cd00115 394503003569 active site 394503003570 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 394503003571 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 394503003572 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 394503003573 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 394503003574 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 394503003575 nickel binding site [ion binding]; other site 394503003576 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 394503003577 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 394503003578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503003579 DNA-binding site [nucleotide binding]; DNA binding site 394503003580 UTRA domain; Region: UTRA; pfam07702 394503003581 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 394503003582 ligand binding site [chemical binding]; other site 394503003583 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 394503003584 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 394503003585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503003586 Walker A/P-loop; other site 394503003587 ATP binding site [chemical binding]; other site 394503003588 Q-loop/lid; other site 394503003589 ABC transporter signature motif; other site 394503003590 Walker B; other site 394503003591 D-loop; other site 394503003592 H-loop/switch region; other site 394503003593 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503003594 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503003595 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 394503003596 TM-ABC transporter signature motif; other site 394503003597 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 394503003598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503003599 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 394503003600 TM-ABC transporter signature motif; other site 394503003601 Isochorismatase family; Region: Isochorismatase; pfam00857 394503003602 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 394503003603 catalytic triad [active] 394503003604 conserved cis-peptide bond; other site 394503003605 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503003606 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 394503003607 substrate binding site [chemical binding]; other site 394503003608 ATP binding site [chemical binding]; other site 394503003609 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 394503003610 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 394503003611 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 394503003612 phosphate binding site [ion binding]; other site 394503003613 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 394503003614 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 394503003615 putative active site [active] 394503003616 metal binding site [ion binding]; metal-binding site 394503003617 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 394503003618 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 394503003619 phosphate binding site [ion binding]; other site 394503003620 SurA N-terminal domain; Region: SurA_N_3; cl07813 394503003621 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 394503003622 Protein of unknown function DUF43; Region: DUF43; pfam01861 394503003623 Probable N6-adenine methyltransferase; Region: N6-adenineMlase; pfam10237 394503003624 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 394503003625 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 394503003626 FkbH-like domain; Region: FkbH; TIGR01686 394503003627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503003628 active site 394503003629 motif I; other site 394503003630 motif II; other site 394503003631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503003632 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 394503003633 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 394503003634 NAD binding site [chemical binding]; other site 394503003635 substrate binding site [chemical binding]; other site 394503003636 homodimer interface [polypeptide binding]; other site 394503003637 active site 394503003638 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 394503003639 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 394503003640 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 394503003641 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 394503003642 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 394503003643 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 394503003644 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 394503003645 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 394503003646 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 394503003647 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 394503003648 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503003649 Interdomain contacts; other site 394503003650 Cytokine receptor motif; other site 394503003651 Kelch motif; Region: Kelch_1; pfam01344 394503003652 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 394503003653 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 394503003654 Kelch motif; Region: Kelch_1; pfam01344 394503003655 Kelch domain; Region: Kelch; smart00612 394503003656 Kelch motif; Region: Kelch_1; pfam01344 394503003657 Kelch domain; Region: Kelch; smart00612 394503003658 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 394503003659 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 394503003660 active site 394503003661 HIGH motif; other site 394503003662 KMSKS motif; other site 394503003663 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 394503003664 tRNA binding surface [nucleotide binding]; other site 394503003665 anticodon binding site; other site 394503003666 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 394503003667 dimer interface [polypeptide binding]; other site 394503003668 putative tRNA-binding site [nucleotide binding]; other site 394503003669 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 394503003670 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503003671 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003672 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003673 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 394503003674 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503003675 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 394503003676 CotH protein; Region: CotH; pfam08757 394503003677 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 394503003678 Predicted transcriptional regulators [Transcription]; Region: COG1695 394503003679 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 394503003680 Phage Tail Collar Domain; Region: Collar; pfam07484 394503003681 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 394503003682 Phage Tail Collar Domain; Region: Collar; pfam07484 394503003683 Phage Tail Collar Domain; Region: Collar; pfam07484 394503003684 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 394503003685 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 394503003686 active site 394503003687 FMN binding site [chemical binding]; other site 394503003688 substrate binding site [chemical binding]; other site 394503003689 putative catalytic residue [active] 394503003690 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 394503003691 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 394503003692 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 394503003693 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 394503003694 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 394503003695 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 394503003696 active site 394503003697 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 394503003698 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 394503003699 UbiA prenyltransferase family; Region: UbiA; pfam01040 394503003700 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 394503003701 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 394503003702 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 394503003703 ApbE family; Region: ApbE; pfam02424 394503003704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503003705 H+ Antiporter protein; Region: 2A0121; TIGR00900 394503003706 putative substrate translocation pore; other site 394503003707 arginine decarboxylase; Provisional; Region: PRK05354 394503003708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 394503003709 dimer interface [polypeptide binding]; other site 394503003710 active site 394503003711 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503003712 catalytic residues [active] 394503003713 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 394503003714 FRG domain; Region: FRG; pfam08867 394503003715 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 394503003716 Predicted membrane protein [Function unknown]; Region: COG2323 394503003717 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 394503003718 Predicted membrane protein [Function unknown]; Region: COG2323 394503003719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 394503003720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 394503003721 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 394503003722 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503003723 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503003724 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 394503003725 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 394503003726 NAD(P) binding pocket [chemical binding]; other site 394503003727 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 394503003728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 394503003729 dimer interface [polypeptide binding]; other site 394503003730 active site 394503003731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503003732 catalytic residues [active] 394503003733 substrate binding site [chemical binding]; other site 394503003734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503003735 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503003736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503003737 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503003738 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003741 dimer interface [polypeptide binding]; other site 394503003742 conserved gate region; other site 394503003743 putative PBP binding loops; other site 394503003744 ABC-ATPase subunit interface; other site 394503003745 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503003746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503003747 dimer interface [polypeptide binding]; other site 394503003748 conserved gate region; other site 394503003749 putative PBP binding loops; other site 394503003750 ABC-ATPase subunit interface; other site 394503003751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503003752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503003753 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 394503003754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 394503003755 Histidine kinase; Region: His_kinase; pfam06580 394503003756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503003757 ATP binding site [chemical binding]; other site 394503003758 Mg2+ binding site [ion binding]; other site 394503003759 G-X-G motif; other site 394503003760 Response regulator receiver domain; Region: Response_reg; pfam00072 394503003761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003762 active site 394503003763 phosphorylation site [posttranslational modification] 394503003764 intermolecular recognition site; other site 394503003765 dimerization interface [polypeptide binding]; other site 394503003766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003767 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503003769 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 394503003770 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 394503003771 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 394503003772 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 394503003773 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 394503003774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 394503003775 DNA binding site [nucleotide binding] 394503003776 active site 394503003777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503003778 Radical SAM superfamily; Region: Radical_SAM; pfam04055 394503003779 FeS/SAM binding site; other site 394503003780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503003781 dimerization interface [polypeptide binding]; other site 394503003782 putative DNA binding site [nucleotide binding]; other site 394503003783 putative Zn2+ binding site [ion binding]; other site 394503003784 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 394503003785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 394503003786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 394503003787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 394503003788 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 394503003789 active site residue [active] 394503003790 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 394503003791 CPxP motif; other site 394503003792 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 394503003793 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503003794 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 394503003795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503003796 S-adenosylmethionine binding site [chemical binding]; other site 394503003797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503003798 S-adenosylmethionine binding site [chemical binding]; other site 394503003799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503003800 non-specific DNA binding site [nucleotide binding]; other site 394503003801 salt bridge; other site 394503003802 sequence-specific DNA binding site [nucleotide binding]; other site 394503003803 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503003804 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503003805 Walker A/P-loop; other site 394503003806 ATP binding site [chemical binding]; other site 394503003807 Q-loop/lid; other site 394503003808 ABC transporter signature motif; other site 394503003809 Walker B; other site 394503003810 D-loop; other site 394503003811 H-loop/switch region; other site 394503003812 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 394503003813 FtsX-like permease family; Region: FtsX; pfam02687 394503003814 FtsX-like permease family; Region: FtsX; pfam02687 394503003815 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503003816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003817 active site 394503003818 phosphorylation site [posttranslational modification] 394503003819 intermolecular recognition site; other site 394503003820 dimerization interface [polypeptide binding]; other site 394503003821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503003822 DNA binding site [nucleotide binding] 394503003823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503003824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 394503003825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503003826 dimer interface [polypeptide binding]; other site 394503003827 phosphorylation site [posttranslational modification] 394503003828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503003829 ATP binding site [chemical binding]; other site 394503003830 Mg2+ binding site [ion binding]; other site 394503003831 G-X-G motif; other site 394503003832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503003833 ATP binding site [chemical binding]; other site 394503003834 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 394503003835 substrate binding site [chemical binding]; other site 394503003836 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 394503003837 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 394503003838 intersubunit interface [polypeptide binding]; other site 394503003839 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503003840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003841 active site 394503003842 phosphorylation site [posttranslational modification] 394503003843 intermolecular recognition site; other site 394503003844 dimerization interface [polypeptide binding]; other site 394503003845 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503003846 DNA binding site [nucleotide binding] 394503003847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503003848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503003849 dimer interface [polypeptide binding]; other site 394503003850 phosphorylation site [posttranslational modification] 394503003851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503003852 ATP binding site [chemical binding]; other site 394503003853 Mg2+ binding site [ion binding]; other site 394503003854 G-X-G motif; other site 394503003855 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 394503003856 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 394503003857 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 394503003858 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 394503003859 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503003860 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 394503003861 Walker A/P-loop; other site 394503003862 ATP binding site [chemical binding]; other site 394503003863 Q-loop/lid; other site 394503003864 ABC transporter signature motif; other site 394503003865 Walker B; other site 394503003866 D-loop; other site 394503003867 H-loop/switch region; other site 394503003868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503003869 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503003870 Transposase; Region: HTH_Tnp_1; cl17663 394503003871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503003872 HTH-like domain; Region: HTH_21; pfam13276 394503003873 Integrase core domain; Region: rve; pfam00665 394503003874 Integrase core domain; Region: rve_2; pfam13333 394503003875 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 394503003876 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 394503003877 dimer interface [polypeptide binding]; other site 394503003878 PYR/PP interface [polypeptide binding]; other site 394503003879 TPP binding site [chemical binding]; other site 394503003880 substrate binding site [chemical binding]; other site 394503003881 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 394503003882 Domain of unknown function; Region: EKR; pfam10371 394503003883 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503003884 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 394503003885 TPP-binding site [chemical binding]; other site 394503003886 dimer interface [polypeptide binding]; other site 394503003887 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 394503003888 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 394503003889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503003890 active site 394503003891 phosphorylation site [posttranslational modification] 394503003892 intermolecular recognition site; other site 394503003893 dimerization interface [polypeptide binding]; other site 394503003894 LytTr DNA-binding domain; Region: LytTR; smart00850 394503003895 Uncharacterized conserved protein [Function unknown]; Region: COG1633 394503003896 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 394503003897 dinuclear metal binding motif [ion binding]; other site 394503003898 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 394503003899 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 394503003900 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 394503003901 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503003902 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503003903 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 394503003904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503003905 NAD(P) binding site [chemical binding]; other site 394503003906 active site 394503003907 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 394503003908 active site 394503003909 metal binding site [ion binding]; metal-binding site 394503003910 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503003911 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 394503003912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 394503003913 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 394503003914 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 394503003915 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 394503003916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503003917 Walker A/P-loop; other site 394503003918 ATP binding site [chemical binding]; other site 394503003919 Q-loop/lid; other site 394503003920 ABC transporter signature motif; other site 394503003921 Walker B; other site 394503003922 D-loop; other site 394503003923 H-loop/switch region; other site 394503003924 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 394503003925 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 394503003926 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 394503003927 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 394503003928 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 394503003929 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 394503003930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503003931 Walker A/P-loop; other site 394503003932 ATP binding site [chemical binding]; other site 394503003933 Q-loop/lid; other site 394503003934 ABC transporter signature motif; other site 394503003935 Walker B; other site 394503003936 D-loop; other site 394503003937 H-loop/switch region; other site 394503003938 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 394503003939 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 394503003940 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 394503003941 PDGLE domain; Region: PDGLE; pfam13190 394503003942 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 394503003943 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 394503003944 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 394503003945 Walker A/P-loop; other site 394503003946 ATP binding site [chemical binding]; other site 394503003947 Q-loop/lid; other site 394503003948 ABC transporter signature motif; other site 394503003949 Walker B; other site 394503003950 D-loop; other site 394503003951 H-loop/switch region; other site 394503003952 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 394503003953 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 394503003954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503003955 TPR motif; other site 394503003956 binding surface 394503003957 TPR repeat; Region: TPR_11; pfam13414 394503003958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503003959 binding surface 394503003960 TPR motif; other site 394503003961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503003962 binding surface 394503003963 TPR repeat; Region: TPR_11; pfam13414 394503003964 TPR motif; other site 394503003965 TPR repeat; Region: TPR_11; pfam13414 394503003966 Tetratricopeptide repeat; Region: TPR_9; pfam13371 394503003967 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 394503003968 homodimer interface [polypeptide binding]; other site 394503003969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503003970 catalytic residue [active] 394503003971 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 394503003972 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 394503003973 ligand binding site [chemical binding]; other site 394503003974 NAD binding site [chemical binding]; other site 394503003975 dimerization interface [polypeptide binding]; other site 394503003976 catalytic site [active] 394503003977 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 394503003978 putative L-serine binding site [chemical binding]; other site 394503003979 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 394503003980 MarR family; Region: MarR; pfam01047 394503003981 MarR family; Region: MarR_2; cl17246 394503003982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503003983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503003984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503003985 Walker A/P-loop; other site 394503003986 ATP binding site [chemical binding]; other site 394503003987 Q-loop/lid; other site 394503003988 ABC transporter signature motif; other site 394503003989 Walker B; other site 394503003990 D-loop; other site 394503003991 H-loop/switch region; other site 394503003992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503003993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503003994 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 394503003995 Walker A/P-loop; other site 394503003996 ATP binding site [chemical binding]; other site 394503003997 Q-loop/lid; other site 394503003998 ABC transporter signature motif; other site 394503003999 Walker B; other site 394503004000 D-loop; other site 394503004001 H-loop/switch region; other site 394503004002 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 394503004003 PRC-barrel domain; Region: PRC; pfam05239 394503004004 PRC-barrel domain; Region: PRC; pfam05239 394503004005 YtxH-like protein; Region: YtxH; cl02079 394503004006 Domain of unknown function DUF20; Region: UPF0118; pfam01594 394503004007 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 394503004008 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 394503004009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 394503004010 active site 394503004011 HIGH motif; other site 394503004012 nucleotide binding site [chemical binding]; other site 394503004013 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 394503004014 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 394503004015 active site 394503004016 KMSKS motif; other site 394503004017 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 394503004018 tRNA binding surface [nucleotide binding]; other site 394503004019 anticodon binding site; other site 394503004020 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 394503004021 NAD synthetase; Reviewed; Region: nadE; PRK02628 394503004022 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 394503004023 multimer interface [polypeptide binding]; other site 394503004024 active site 394503004025 catalytic triad [active] 394503004026 protein interface 1 [polypeptide binding]; other site 394503004027 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 394503004028 homodimer interface [polypeptide binding]; other site 394503004029 NAD binding pocket [chemical binding]; other site 394503004030 ATP binding pocket [chemical binding]; other site 394503004031 Mg binding site [ion binding]; other site 394503004032 active-site loop [active] 394503004033 Uncharacterized conserved protein [Function unknown]; Region: COG1624 394503004034 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 394503004035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 394503004036 YbbR-like protein; Region: YbbR; pfam07949 394503004037 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 394503004038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 394503004039 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 394503004040 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 394503004041 active site 394503004042 substrate binding site [chemical binding]; other site 394503004043 metal binding site [ion binding]; metal-binding site 394503004044 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 394503004045 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 394503004046 glutaminase active site [active] 394503004047 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 394503004048 dimer interface [polypeptide binding]; other site 394503004049 active site 394503004050 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 394503004051 dimer interface [polypeptide binding]; other site 394503004052 active site 394503004053 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004054 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503004056 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503004057 Transposase; Region: HTH_Tnp_1; cl17663 394503004058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503004059 HTH-like domain; Region: HTH_21; pfam13276 394503004060 Integrase core domain; Region: rve; pfam00665 394503004061 Integrase core domain; Region: rve_2; pfam13333 394503004062 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 394503004063 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 394503004064 active site 394503004065 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 394503004066 active site 394503004067 substrate binding site [chemical binding]; other site 394503004068 ATP binding site [chemical binding]; other site 394503004069 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 394503004070 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 394503004071 classical (c) SDRs; Region: SDR_c; cd05233 394503004072 NAD(P) binding site [chemical binding]; other site 394503004073 active site 394503004074 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 394503004075 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 394503004076 dimer interface [polypeptide binding]; other site 394503004077 active site 394503004078 CoA binding pocket [chemical binding]; other site 394503004079 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 394503004080 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 394503004081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503004082 acyl-activating enzyme (AAE) consensus motif; other site 394503004083 AMP binding site [chemical binding]; other site 394503004084 active site 394503004085 CoA binding site [chemical binding]; other site 394503004086 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503004087 Winged helix-turn helix; Region: HTH_29; pfam13551 394503004088 Homeodomain-like domain; Region: HTH_32; pfam13565 394503004089 Integrase core domain; Region: rve; pfam00665 394503004090 Integrase core domain; Region: rve_3; pfam13683 394503004091 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 394503004092 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 394503004093 Predicted transcriptional regulator [Transcription]; Region: COG4189 394503004094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503004095 putative DNA binding site [nucleotide binding]; other site 394503004096 dimerization interface [polypeptide binding]; other site 394503004097 putative Zn2+ binding site [ion binding]; other site 394503004098 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 394503004099 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 394503004100 putative ligand binding site [chemical binding]; other site 394503004101 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 394503004102 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503004103 Walker A/P-loop; other site 394503004104 ATP binding site [chemical binding]; other site 394503004105 Q-loop/lid; other site 394503004106 ABC transporter signature motif; other site 394503004107 Walker B; other site 394503004108 D-loop; other site 394503004109 H-loop/switch region; other site 394503004110 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503004111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503004112 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503004113 TM-ABC transporter signature motif; other site 394503004114 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503004115 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503004116 TM-ABC transporter signature motif; other site 394503004117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503004118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503004119 dimerization interface [polypeptide binding]; other site 394503004120 Histidine kinase; Region: His_kinase; pfam06580 394503004121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503004122 ATP binding site [chemical binding]; other site 394503004123 Mg2+ binding site [ion binding]; other site 394503004124 G-X-G motif; other site 394503004125 Response regulator receiver domain; Region: Response_reg; pfam00072 394503004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503004127 active site 394503004128 phosphorylation site [posttranslational modification] 394503004129 intermolecular recognition site; other site 394503004130 dimerization interface [polypeptide binding]; other site 394503004131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503004132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503004133 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 394503004134 substrate binding site [chemical binding]; other site 394503004135 active site 394503004136 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004137 metal binding site [ion binding]; metal-binding site 394503004138 ligand binding site [chemical binding]; other site 394503004139 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004140 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 394503004141 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004142 metal binding site [ion binding]; metal-binding site 394503004143 ligand binding site [chemical binding]; other site 394503004144 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004145 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 394503004146 substrate binding site [chemical binding]; other site 394503004147 active site 394503004148 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004149 metal binding site [ion binding]; metal-binding site 394503004150 ligand binding site [chemical binding]; other site 394503004151 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004152 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004153 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 394503004154 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 394503004155 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004156 metal binding site [ion binding]; metal-binding site 394503004157 ligand binding site [chemical binding]; other site 394503004158 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 394503004159 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 394503004160 active site 394503004161 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004162 metal binding site [ion binding]; metal-binding site 394503004163 ligand binding site [chemical binding]; other site 394503004164 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004165 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004166 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 394503004167 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 394503004168 active site 394503004169 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004170 metal binding site [ion binding]; metal-binding site 394503004171 ligand binding site [chemical binding]; other site 394503004172 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004173 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004174 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 394503004175 substrate binding site [chemical binding]; other site 394503004176 active site 394503004177 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004178 metal binding site [ion binding]; metal-binding site 394503004179 ligand binding site [chemical binding]; other site 394503004180 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004181 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 394503004182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 394503004183 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503004184 Beta/Gamma crystallin; Region: Crystall; cl02528 394503004185 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004186 alpha-galactosidase; Region: PLN02808; cl17638 394503004187 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004188 metal binding site [ion binding]; metal-binding site 394503004189 ligand binding site [chemical binding]; other site 394503004190 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004191 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 394503004192 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004193 metal binding site [ion binding]; metal-binding site 394503004194 ligand binding site [chemical binding]; other site 394503004195 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004196 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503004197 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 394503004198 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 394503004199 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 394503004200 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004201 metal binding site [ion binding]; metal-binding site 394503004202 ligand binding site [chemical binding]; other site 394503004203 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 394503004204 active site 394503004205 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004206 metal binding site [ion binding]; metal-binding site 394503004207 ligand binding site [chemical binding]; other site 394503004208 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004209 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004210 Domain of unknown function (DUF303); Region: DUF303; pfam03629 394503004211 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 394503004212 sugar binding site [chemical binding]; other site 394503004213 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004214 metal binding site [ion binding]; metal-binding site 394503004215 ligand binding site [chemical binding]; other site 394503004216 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004217 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 394503004218 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 394503004219 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503004220 metal binding site [ion binding]; metal-binding site 394503004221 ligand binding site [chemical binding]; other site 394503004222 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004223 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 394503004224 catalytic residues [active] 394503004225 Pectic acid lyase; Region: Pec_lyase; pfam09492 394503004226 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004227 Pectinesterase; Region: Pectinesterase; pfam01095 394503004228 putative pectinesterase; Region: PLN02432; cl01911 394503004229 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503004232 Walker A/P-loop; other site 394503004233 ATP binding site [chemical binding]; other site 394503004234 Q-loop/lid; other site 394503004235 ABC transporter signature motif; other site 394503004236 Walker B; other site 394503004237 D-loop; other site 394503004238 H-loop/switch region; other site 394503004239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503004241 Walker A/P-loop; other site 394503004242 ATP binding site [chemical binding]; other site 394503004243 Q-loop/lid; other site 394503004244 ABC transporter signature motif; other site 394503004245 Walker B; other site 394503004246 D-loop; other site 394503004247 H-loop/switch region; other site 394503004248 endoglucanase; Region: PLN02308 394503004249 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 394503004250 Cellulose binding domain; Region: CBM_3; smart01067 394503004251 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004252 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503004254 dimerization interface [polypeptide binding]; other site 394503004255 Histidine kinase; Region: His_kinase; pfam06580 394503004256 Response regulator receiver domain; Region: Response_reg; pfam00072 394503004257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503004258 active site 394503004259 phosphorylation site [posttranslational modification] 394503004260 intermolecular recognition site; other site 394503004261 dimerization interface [polypeptide binding]; other site 394503004262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503004263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503004264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503004265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503004266 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503004267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 394503004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503004269 dimer interface [polypeptide binding]; other site 394503004270 ABC-ATPase subunit interface; other site 394503004271 putative PBP binding loops; other site 394503004272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503004273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503004274 dimer interface [polypeptide binding]; other site 394503004275 conserved gate region; other site 394503004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 394503004277 ABC-ATPase subunit interface; other site 394503004278 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 394503004279 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 394503004280 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 394503004281 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 394503004282 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 394503004283 active site 394503004284 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 394503004285 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 394503004286 Putative esterase; Region: Esterase; pfam00756 394503004287 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 394503004288 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 394503004289 active site 394503004290 zinc binding site [ion binding]; other site 394503004291 Domain of unknown function (DUF303); Region: DUF303; pfam03629 394503004292 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503004293 Domain of unknown function (DUF303); Region: DUF303; pfam03629 394503004294 Transcriptional regulators [Transcription]; Region: FadR; COG2186 394503004295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503004296 DNA-binding site [nucleotide binding]; DNA binding site 394503004297 FCD domain; Region: FCD; pfam07729 394503004298 Dehydratase family; Region: ILVD_EDD; pfam00920 394503004299 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 394503004300 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 394503004301 inhibitor site; inhibition site 394503004302 active site 394503004303 dimer interface [polypeptide binding]; other site 394503004304 catalytic residue [active] 394503004305 cobalt transport protein CbiM; Validated; Region: PRK08319 394503004306 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 394503004307 cobalt transport protein CbiN; Provisional; Region: PRK02898 394503004308 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 394503004309 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 394503004310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 394503004311 Walker A/P-loop; other site 394503004312 ATP binding site [chemical binding]; other site 394503004313 Q-loop/lid; other site 394503004314 ABC transporter signature motif; other site 394503004315 Walker B; other site 394503004316 D-loop; other site 394503004317 H-loop/switch region; other site 394503004318 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 394503004319 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 394503004320 active site 394503004321 SAM binding site [chemical binding]; other site 394503004322 homodimer interface [polypeptide binding]; other site 394503004323 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 394503004324 active site 394503004325 SAM binding site [chemical binding]; other site 394503004326 homodimer interface [polypeptide binding]; other site 394503004327 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 394503004328 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 394503004329 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 394503004330 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 394503004331 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 394503004332 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 394503004333 tRNA; other site 394503004334 putative tRNA binding site [nucleotide binding]; other site 394503004335 putative NADP binding site [chemical binding]; other site 394503004336 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 394503004337 active site 394503004338 SAM binding site [chemical binding]; other site 394503004339 homodimer interface [polypeptide binding]; other site 394503004340 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 394503004341 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 394503004342 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 394503004343 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 394503004344 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 394503004345 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 394503004346 domain interfaces; other site 394503004347 active site 394503004348 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 394503004349 active site 394503004350 SAM binding site [chemical binding]; other site 394503004351 homodimer interface [polypeptide binding]; other site 394503004352 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 394503004353 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 394503004354 active site 394503004355 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 394503004356 dimer interface [polypeptide binding]; other site 394503004357 active site 394503004358 Schiff base residues; other site 394503004359 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 394503004360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503004361 inhibitor-cofactor binding pocket; inhibition site 394503004362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503004363 catalytic residue [active] 394503004364 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 394503004365 putative active site [active] 394503004366 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 394503004367 active site 394503004368 putative homodimer interface [polypeptide binding]; other site 394503004369 SAM binding site [chemical binding]; other site 394503004370 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 394503004371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503004372 S-adenosylmethionine binding site [chemical binding]; other site 394503004373 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 394503004374 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 394503004375 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 394503004376 catalytic triad [active] 394503004377 cobyric acid synthase; Provisional; Region: PRK00784 394503004378 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 394503004379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 394503004380 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 394503004381 catalytic triad [active] 394503004382 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 394503004383 Precorrin-8X methylmutase; Region: CbiC; pfam02570 394503004384 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 394503004385 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 394503004386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503004387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503004388 homodimer interface [polypeptide binding]; other site 394503004389 catalytic residue [active] 394503004390 5-methylribose kinase; Reviewed; Region: PRK12396 394503004391 Phosphotransferase enzyme family; Region: APH; pfam01636 394503004392 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 394503004393 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 394503004394 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 394503004395 intersubunit interface [polypeptide binding]; other site 394503004396 active site 394503004397 Zn2+ binding site [ion binding]; other site 394503004398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503004399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503004401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503004402 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 394503004403 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 394503004404 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 394503004405 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 394503004406 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004407 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503004408 Transposase; Region: HTH_Tnp_1; pfam01527 394503004409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503004410 putative transposase OrfB; Reviewed; Region: PHA02517 394503004411 HTH-like domain; Region: HTH_21; pfam13276 394503004412 Integrase core domain; Region: rve; pfam00665 394503004413 Integrase core domain; Region: rve_3; pfam13683 394503004414 Penicillinase repressor; Region: Pencillinase_R; cl17580 394503004415 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 394503004416 CotH protein; Region: CotH; pfam08757 394503004417 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 394503004418 putative metal binding residues [ion binding]; other site 394503004419 signature motif; other site 394503004420 dimer interface [polypeptide binding]; other site 394503004421 active site 394503004422 polyP binding site; other site 394503004423 substrate binding site [chemical binding]; other site 394503004424 acceptor-phosphate pocket; other site 394503004425 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 394503004426 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 394503004427 active site 394503004428 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 394503004429 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 394503004430 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 394503004431 Ligand binding site; other site 394503004432 Putative Catalytic site; other site 394503004433 DXD motif; other site 394503004434 thymidylate synthase; Reviewed; Region: thyA; PRK01827 394503004435 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 394503004436 dimerization interface [polypeptide binding]; other site 394503004437 active site 394503004438 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 394503004439 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 394503004440 folate binding site [chemical binding]; other site 394503004441 NADP+ binding site [chemical binding]; other site 394503004442 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 394503004443 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 394503004444 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 394503004445 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 394503004446 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 394503004447 23S rRNA binding site [nucleotide binding]; other site 394503004448 L21 binding site [polypeptide binding]; other site 394503004449 L13 binding site [polypeptide binding]; other site 394503004450 DNA polymerase IV; Validated; Region: PRK01810 394503004451 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 394503004452 active site 394503004453 DNA binding site [nucleotide binding] 394503004454 Flagellar protein YcgR; Region: YcgR_2; pfam12945 394503004455 PilZ domain; Region: PilZ; pfam07238 394503004456 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 394503004457 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 394503004458 putative acyl-acceptor binding pocket; other site 394503004459 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 394503004460 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 394503004461 B12 binding site [chemical binding]; other site 394503004462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503004463 FeS/SAM binding site; other site 394503004464 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 394503004465 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 394503004466 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 394503004467 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 394503004468 homodimer interface [polypeptide binding]; other site 394503004469 oligonucleotide binding site [chemical binding]; other site 394503004470 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 394503004471 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 394503004472 hypothetical protein; Provisional; Region: PRK14553 394503004473 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 394503004474 GTPase CgtA; Reviewed; Region: obgE; PRK12297 394503004475 GTP1/OBG; Region: GTP1_OBG; pfam01018 394503004476 Obg GTPase; Region: Obg; cd01898 394503004477 G1 box; other site 394503004478 GTP/Mg2+ binding site [chemical binding]; other site 394503004479 Switch I region; other site 394503004480 G2 box; other site 394503004481 G3 box; other site 394503004482 Switch II region; other site 394503004483 G4 box; other site 394503004484 G5 box; other site 394503004485 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 394503004486 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 394503004487 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 394503004488 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 394503004489 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 394503004490 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 394503004491 GTP cyclohydrolase I; Provisional; Region: PLN03044 394503004492 active site 394503004493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503004494 Zn2+ binding site [ion binding]; other site 394503004495 Mg2+ binding site [ion binding]; other site 394503004496 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 394503004497 dihydropteroate synthase; Region: DHPS; TIGR01496 394503004498 substrate binding pocket [chemical binding]; other site 394503004499 dimer interface [polypeptide binding]; other site 394503004500 inhibitor binding site; inhibition site 394503004501 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 394503004502 homooctamer interface [polypeptide binding]; other site 394503004503 active site 394503004504 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 394503004505 catalytic center binding site [active] 394503004506 ATP binding site [chemical binding]; other site 394503004507 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 394503004508 glycogen synthase; Provisional; Region: glgA; PRK00654 394503004509 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 394503004510 ADP-binding pocket [chemical binding]; other site 394503004511 homodimer interface [polypeptide binding]; other site 394503004512 TSCPD domain; Region: TSCPD; cl14834 394503004513 YtxH-like protein; Region: YtxH; pfam12732 394503004514 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 394503004515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 394503004516 S-layer homology domain; Region: SLH; pfam00395 394503004517 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 394503004518 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 394503004519 putative active site [active] 394503004520 putative metal binding site [ion binding]; other site 394503004521 argininosuccinate lyase; Provisional; Region: PRK00855 394503004522 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 394503004523 active sites [active] 394503004524 tetramer interface [polypeptide binding]; other site 394503004525 argininosuccinate synthase; Provisional; Region: PRK13820 394503004526 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 394503004527 ANP binding site [chemical binding]; other site 394503004528 Substrate Binding Site II [chemical binding]; other site 394503004529 Substrate Binding Site I [chemical binding]; other site 394503004530 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 394503004531 active site 394503004532 putative DNA-binding cleft [nucleotide binding]; other site 394503004533 dimer interface [polypeptide binding]; other site 394503004534 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 394503004535 RuvA N terminal domain; Region: RuvA_N; pfam01330 394503004536 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 394503004537 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 394503004538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503004539 Walker A motif; other site 394503004540 ATP binding site [chemical binding]; other site 394503004541 Walker B motif; other site 394503004542 arginine finger; other site 394503004543 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 394503004544 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 394503004545 Ligand Binding Site [chemical binding]; other site 394503004546 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503004547 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503004548 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503004549 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503004550 active site 394503004551 metal binding site [ion binding]; metal-binding site 394503004552 Sporulation and spore germination; Region: Germane; pfam10646 394503004553 Sporulation and spore germination; Region: Germane; pfam10646 394503004554 ribonuclease PH; Reviewed; Region: rph; PRK00173 394503004555 Ribonuclease PH; Region: RNase_PH_bact; cd11362 394503004556 hexamer interface [polypeptide binding]; other site 394503004557 active site 394503004558 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 394503004559 active site 394503004560 dimerization interface [polypeptide binding]; other site 394503004561 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 394503004562 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503004563 active site 394503004564 metal binding site [ion binding]; metal-binding site 394503004565 homotetramer interface [polypeptide binding]; other site 394503004566 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 394503004567 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 394503004568 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 394503004569 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 394503004570 4Fe-4S binding domain; Region: Fer4_6; pfam12837 394503004571 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503004572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 394503004573 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 394503004574 ligand binding site [chemical binding]; other site 394503004575 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 394503004576 putative switch regulator; other site 394503004577 non-specific DNA interactions [nucleotide binding]; other site 394503004578 DNA binding site [nucleotide binding] 394503004579 sequence specific DNA binding site [nucleotide binding]; other site 394503004580 putative cAMP binding site [chemical binding]; other site 394503004581 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 394503004582 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 394503004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 394503004584 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 394503004585 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 394503004586 active site 394503004587 (T/H)XGH motif; other site 394503004588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503004589 Zn2+ binding site [ion binding]; other site 394503004590 Mg2+ binding site [ion binding]; other site 394503004591 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 394503004592 Oligomerisation domain; Region: Oligomerisation; pfam02410 394503004593 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 394503004594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503004596 Walker A/P-loop; other site 394503004597 ATP binding site [chemical binding]; other site 394503004598 Q-loop/lid; other site 394503004599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004600 ABC transporter signature motif; other site 394503004601 Walker B; other site 394503004602 D-loop; other site 394503004603 ABC transporter; Region: ABC_tran_2; pfam12848 394503004604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004605 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 394503004606 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 394503004607 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 394503004608 acyl-activating enzyme (AAE) consensus motif; other site 394503004609 putative AMP binding site [chemical binding]; other site 394503004610 putative active site [active] 394503004611 putative CoA binding site [chemical binding]; other site 394503004612 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 394503004613 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 394503004614 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 394503004615 SLBB domain; Region: SLBB; pfam10531 394503004616 comEA protein; Region: comE; TIGR01259 394503004617 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 394503004618 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 394503004619 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 394503004620 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 394503004621 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 394503004622 active site 394503004623 dimer interface [polypeptide binding]; other site 394503004624 motif 1; other site 394503004625 motif 2; other site 394503004626 motif 3; other site 394503004627 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 394503004628 anticodon binding site; other site 394503004629 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 394503004630 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 394503004631 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 394503004632 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 394503004633 active site 394503004634 dimer interface [polypeptide binding]; other site 394503004635 motif 1; other site 394503004636 motif 2; other site 394503004637 motif 3; other site 394503004638 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 394503004639 anticodon binding site; other site 394503004640 S-layer homology domain; Region: SLH; pfam00395 394503004641 S-layer homology domain; Region: SLH; pfam00395 394503004642 S-layer homology domain; Region: SLH; pfam00395 394503004643 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503004644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503004645 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503004646 Transposase; Region: HTH_Tnp_1; cl17663 394503004647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503004648 HTH-like domain; Region: HTH_21; pfam13276 394503004649 Integrase core domain; Region: rve; pfam00665 394503004650 Integrase core domain; Region: rve_2; pfam13333 394503004651 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 394503004652 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 394503004653 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 394503004654 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 394503004655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503004656 dimerization interface [polypeptide binding]; other site 394503004657 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503004658 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503004659 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503004660 dimer interface [polypeptide binding]; other site 394503004661 putative CheW interface [polypeptide binding]; other site 394503004662 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 394503004663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004665 ABC transporter; Region: ABC_tran_2; pfam12848 394503004666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503004667 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004668 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503004669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503004670 Walker A/P-loop; other site 394503004671 ATP binding site [chemical binding]; other site 394503004672 Q-loop/lid; other site 394503004673 ABC transporter signature motif; other site 394503004674 Walker B; other site 394503004675 D-loop; other site 394503004676 H-loop/switch region; other site 394503004677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503004679 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 394503004680 Walker A/P-loop; other site 394503004681 ATP binding site [chemical binding]; other site 394503004682 Q-loop/lid; other site 394503004683 ABC transporter signature motif; other site 394503004684 Walker B; other site 394503004685 D-loop; other site 394503004686 H-loop/switch region; other site 394503004687 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 394503004688 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 394503004689 dimer interface [polypeptide binding]; other site 394503004690 PYR/PP interface [polypeptide binding]; other site 394503004691 TPP binding site [chemical binding]; other site 394503004692 substrate binding site [chemical binding]; other site 394503004693 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 394503004694 TPP-binding site; other site 394503004695 4Fe-4S binding domain; Region: Fer4; pfam00037 394503004696 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 394503004697 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 394503004698 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 394503004699 active site 394503004700 dimer interfaces [polypeptide binding]; other site 394503004701 catalytic residues [active] 394503004702 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503004703 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 394503004704 acyl-activating enzyme (AAE) consensus motif; other site 394503004705 AMP binding site [chemical binding]; other site 394503004706 active site 394503004707 CoA binding site [chemical binding]; other site 394503004708 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 394503004709 FMN-binding domain; Region: FMN_bind; cl01081 394503004710 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 394503004711 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 394503004712 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 394503004713 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 394503004714 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 394503004715 DNA gyrase B; Region: DNA_gyraseB; pfam00204 394503004716 ATP binding site [chemical binding]; other site 394503004717 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 394503004718 active site 394503004719 metal binding site [ion binding]; metal-binding site 394503004720 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 394503004721 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 394503004722 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 394503004723 CAP-like domain; other site 394503004724 active site 394503004725 primary dimer interface [polypeptide binding]; other site 394503004726 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503004727 Winged helix-turn helix; Region: HTH_29; pfam13551 394503004728 Homeodomain-like domain; Region: HTH_32; pfam13565 394503004729 Integrase core domain; Region: rve; pfam00665 394503004730 Integrase core domain; Region: rve_3; pfam13683 394503004731 conserved hypothetical integral membrane protein; Region: TIGR03766 394503004732 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 394503004733 active site 394503004734 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 394503004735 hydroxyglutarate oxidase; Provisional; Region: PRK11728 394503004736 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 394503004737 QueT transporter; Region: QueT; pfam06177 394503004738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503004739 active site 394503004740 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 394503004741 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 394503004742 putative ligand binding site [chemical binding]; other site 394503004743 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 394503004744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503004745 Walker A/P-loop; other site 394503004746 ATP binding site [chemical binding]; other site 394503004747 Q-loop/lid; other site 394503004748 ABC transporter signature motif; other site 394503004749 Walker B; other site 394503004750 D-loop; other site 394503004751 H-loop/switch region; other site 394503004752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503004753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503004754 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 394503004755 TM-ABC transporter signature motif; other site 394503004756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503004757 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 394503004758 TM-ABC transporter signature motif; other site 394503004759 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 394503004760 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 394503004761 active site 394503004762 HIGH motif; other site 394503004763 dimer interface [polypeptide binding]; other site 394503004764 KMSKS motif; other site 394503004765 Predicted membrane protein [Function unknown]; Region: COG1971 394503004766 Domain of unknown function DUF; Region: DUF204; pfam02659 394503004767 Domain of unknown function DUF; Region: DUF204; pfam02659 394503004768 excinuclease ABC subunit B; Provisional; Region: PRK05298 394503004769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503004770 ATP binding site [chemical binding]; other site 394503004771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503004772 nucleotide binding region [chemical binding]; other site 394503004773 ATP-binding site [chemical binding]; other site 394503004774 Ultra-violet resistance protein B; Region: UvrB; pfam12344 394503004775 UvrB/uvrC motif; Region: UVR; pfam02151 394503004776 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 394503004777 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 394503004778 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 394503004779 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 394503004780 active site 394503004781 substrate binding site [chemical binding]; other site 394503004782 metal binding site [ion binding]; metal-binding site 394503004783 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 394503004784 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503004785 putative active site [active] 394503004786 putative metal binding site [ion binding]; other site 394503004787 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 394503004788 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 394503004789 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503004790 Zn2+ binding site [ion binding]; other site 394503004791 Mg2+ binding site [ion binding]; other site 394503004792 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 394503004793 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 394503004794 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 394503004795 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 394503004796 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 394503004797 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 394503004798 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 394503004799 ligand binding site [chemical binding]; other site 394503004800 flexible hinge region; other site 394503004801 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 394503004802 hybrid cluster protein; Provisional; Region: PRK05290 394503004803 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 394503004804 hybrid metal cluster; other site 394503004805 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 394503004806 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 394503004807 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 394503004808 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 394503004809 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 394503004810 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503004811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503004812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503004813 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004814 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503004815 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 394503004816 Walker A/P-loop; other site 394503004817 ATP binding site [chemical binding]; other site 394503004818 Q-loop/lid; other site 394503004819 ABC transporter signature motif; other site 394503004820 Walker B; other site 394503004821 D-loop; other site 394503004822 H-loop/switch region; other site 394503004823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503004824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503004825 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 394503004826 Walker A/P-loop; other site 394503004827 ATP binding site [chemical binding]; other site 394503004828 Q-loop/lid; other site 394503004829 ABC transporter signature motif; other site 394503004830 Walker B; other site 394503004831 D-loop; other site 394503004832 H-loop/switch region; other site 394503004833 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 394503004834 active site 394503004835 catalytic residues [active] 394503004836 Probable zinc-binding domain; Region: zf-trcl; pfam13451 394503004837 MutS domain III; Region: MutS_III; pfam05192 394503004838 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 394503004839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503004840 Walker A/P-loop; other site 394503004841 ATP binding site [chemical binding]; other site 394503004842 Q-loop/lid; other site 394503004843 ABC transporter signature motif; other site 394503004844 Walker B; other site 394503004845 D-loop; other site 394503004846 H-loop/switch region; other site 394503004847 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 394503004848 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 394503004849 G1 box; other site 394503004850 putative GEF interaction site [polypeptide binding]; other site 394503004851 GTP/Mg2+ binding site [chemical binding]; other site 394503004852 Switch I region; other site 394503004853 G2 box; other site 394503004854 G3 box; other site 394503004855 Switch II region; other site 394503004856 G4 box; other site 394503004857 G5 box; other site 394503004858 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 394503004859 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 394503004860 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 394503004861 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 394503004862 active site 394503004863 DRTGG domain; Region: DRTGG; pfam07085 394503004864 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 394503004865 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 394503004866 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 394503004867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503004868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 394503004869 DNA binding site [nucleotide binding] 394503004870 domain linker motif; other site 394503004871 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 394503004872 dimerization interface [polypeptide binding]; other site 394503004873 ligand binding site [chemical binding]; other site 394503004874 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 394503004875 Protein of unknown function, DUF608; Region: DUF608; pfam04685 394503004876 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 394503004877 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 394503004878 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 394503004879 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 394503004880 dimer interface [polypeptide binding]; other site 394503004881 motif 1; other site 394503004882 active site 394503004883 motif 2; other site 394503004884 motif 3; other site 394503004885 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 394503004886 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 394503004887 putative tRNA-binding site [nucleotide binding]; other site 394503004888 B3/4 domain; Region: B3_4; pfam03483 394503004889 tRNA synthetase B5 domain; Region: B5; smart00874 394503004890 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 394503004891 motif 1; other site 394503004892 dimer interface [polypeptide binding]; other site 394503004893 active site 394503004894 motif 2; other site 394503004895 motif 3; other site 394503004896 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 394503004897 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503004898 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 394503004899 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 394503004900 active site 394503004901 dimer interface [polypeptide binding]; other site 394503004902 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 394503004903 dimer interface [polypeptide binding]; other site 394503004904 active site 394503004905 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 394503004906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503004907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503004908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503004909 TPR motif; other site 394503004910 binding surface 394503004911 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 394503004912 Tetratricopeptide repeat; Region: TPR_6; pfam13174 394503004913 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 394503004914 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 394503004915 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 394503004916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503004917 catalytic residue [active] 394503004918 hypothetical protein; Provisional; Region: PRK04435 394503004919 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 394503004920 homoserine dehydrogenase; Provisional; Region: PRK06349 394503004921 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 394503004922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 394503004923 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 394503004924 Trp repressor protein; Region: Trp_repressor; cl17266 394503004925 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 394503004926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503004927 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 394503004928 SEC-C motif; Region: SEC-C; pfam02810 394503004929 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 394503004930 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 394503004931 active site 394503004932 PHP Thumb interface [polypeptide binding]; other site 394503004933 metal binding site [ion binding]; metal-binding site 394503004934 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 394503004935 generic binding surface II; other site 394503004936 generic binding surface I; other site 394503004937 transcription attenuation protein MtrB; Provisional; Region: PRK13251 394503004938 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 394503004939 active site 394503004940 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 394503004941 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 394503004942 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 394503004943 HSP70 interaction site [polypeptide binding]; other site 394503004944 Tetratricopeptide repeat; Region: TPR_16; pfam13432 394503004945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503004946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503004947 non-specific DNA binding site [nucleotide binding]; other site 394503004948 salt bridge; other site 394503004949 sequence-specific DNA binding site [nucleotide binding]; other site 394503004950 Cupin domain; Region: Cupin_2; pfam07883 394503004951 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503004952 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 394503004953 acyl-activating enzyme (AAE) consensus motif; other site 394503004954 AMP binding site [chemical binding]; other site 394503004955 active site 394503004956 CoA binding site [chemical binding]; other site 394503004957 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 394503004958 MutS domain III; Region: MutS_III; pfam05192 394503004959 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 394503004960 Walker A/P-loop; other site 394503004961 ATP binding site [chemical binding]; other site 394503004962 Q-loop/lid; other site 394503004963 ABC transporter signature motif; other site 394503004964 Walker B; other site 394503004965 D-loop; other site 394503004966 H-loop/switch region; other site 394503004967 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 394503004968 Smr domain; Region: Smr; pfam01713 394503004969 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 394503004970 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 394503004971 G1 box; other site 394503004972 putative GEF interaction site [polypeptide binding]; other site 394503004973 GTP/Mg2+ binding site [chemical binding]; other site 394503004974 Switch I region; other site 394503004975 G2 box; other site 394503004976 G3 box; other site 394503004977 Switch II region; other site 394503004978 G4 box; other site 394503004979 G5 box; other site 394503004980 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 394503004981 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 394503004982 YceG-like family; Region: YceG; pfam02618 394503004983 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 394503004984 dimerization interface [polypeptide binding]; other site 394503004985 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 394503004986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503004987 S-adenosylmethionine binding site [chemical binding]; other site 394503004988 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 394503004989 Peptidase family U32; Region: Peptidase_U32; pfam01136 394503004990 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 394503004991 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 394503004992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503004993 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 394503004994 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 394503004995 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503004996 Winged helix-turn helix; Region: HTH_29; pfam13551 394503004997 Homeodomain-like domain; Region: HTH_32; pfam13565 394503004998 Integrase core domain; Region: rve; pfam00665 394503004999 Integrase core domain; Region: rve_3; pfam13683 394503005000 Family of unknown function (DUF694); Region: DUF694; pfam05107 394503005001 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 394503005002 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 394503005003 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 394503005004 putative transposase OrfB; Reviewed; Region: PHA02517 394503005005 HTH-like domain; Region: HTH_21; pfam13276 394503005006 Integrase core domain; Region: rve; pfam00665 394503005007 Integrase core domain; Region: rve_3; pfam13683 394503005008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005009 Transposase; Region: HTH_Tnp_1; pfam01527 394503005010 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 394503005011 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 394503005012 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 394503005013 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 394503005014 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503005015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 394503005016 DNA binding residues [nucleotide binding] 394503005017 HYR domain; Region: HYR; pfam02494 394503005018 Cellulose binding domain; Region: CBM_3; pfam00942 394503005019 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 394503005020 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 394503005021 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 394503005022 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 394503005023 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 394503005024 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 394503005025 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 394503005026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503005027 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 394503005028 Walker A motif; other site 394503005029 ATP binding site [chemical binding]; other site 394503005030 Walker B motif; other site 394503005031 arginine finger; other site 394503005032 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 394503005033 tail sheath protein; Provisional; Region: 18; PHA02539 394503005034 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 394503005035 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 394503005036 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 394503005037 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 394503005038 Phage protein D [General function prediction only]; Region: COG3500 394503005039 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 394503005040 PAAR motif; Region: PAAR_motif; cl15808 394503005041 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 394503005042 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 394503005043 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 394503005044 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 394503005045 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 394503005046 phage tail protein domain; Region: tail_TIGR02242 394503005047 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 394503005048 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 394503005049 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 394503005050 Uncharacterized conserved protein [Function unknown]; Region: COG2966 394503005051 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 394503005052 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 394503005053 single-stranded DNA-binding protein; Provisional; Region: PRK05813 394503005054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 394503005055 dimer interface [polypeptide binding]; other site 394503005056 ssDNA binding site [nucleotide binding]; other site 394503005057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503005058 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 394503005059 ApbE family; Region: ApbE; pfam02424 394503005060 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 394503005061 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 394503005062 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 394503005063 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 394503005064 substrate binding pocket [chemical binding]; other site 394503005065 chain length determination region; other site 394503005066 substrate-Mg2+ binding site; other site 394503005067 catalytic residues [active] 394503005068 aspartate-rich region 1; other site 394503005069 active site lid residues [active] 394503005070 aspartate-rich region 2; other site 394503005071 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 394503005072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503005073 ATP binding site [chemical binding]; other site 394503005074 putative Mg++ binding site [ion binding]; other site 394503005075 nucleotide binding region [chemical binding]; other site 394503005076 helicase superfamily c-terminal domain; Region: HELICc; smart00490 394503005077 ATP-binding site [chemical binding]; other site 394503005078 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 394503005079 active site 394503005080 catalytic residues [active] 394503005081 metal binding site [ion binding]; metal-binding site 394503005082 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 394503005083 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 394503005084 putative active site [active] 394503005085 substrate binding site [chemical binding]; other site 394503005086 putative cosubstrate binding site; other site 394503005087 catalytic site [active] 394503005088 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 394503005089 substrate binding site [chemical binding]; other site 394503005090 Protein of unknown function DUF116; Region: DUF116; pfam01976 394503005091 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 394503005092 16S rRNA methyltransferase B; Provisional; Region: PRK14902 394503005093 NusB family; Region: NusB; pfam01029 394503005094 putative RNA binding site [nucleotide binding]; other site 394503005095 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 394503005096 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 394503005097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005098 FeS/SAM binding site; other site 394503005099 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 394503005100 Protein phosphatase 2C; Region: PP2C; pfam00481 394503005101 active site 394503005102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 394503005103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 394503005104 active site 394503005105 ATP binding site [chemical binding]; other site 394503005106 substrate binding site [chemical binding]; other site 394503005107 activation loop (A-loop); other site 394503005108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 394503005109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 394503005110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 394503005111 GTPase RsgA; Reviewed; Region: PRK00098 394503005112 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 394503005113 RNA binding site [nucleotide binding]; other site 394503005114 homodimer interface [polypeptide binding]; other site 394503005115 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 394503005116 GTPase/Zn-binding domain interface [polypeptide binding]; other site 394503005117 GTP/Mg2+ binding site [chemical binding]; other site 394503005118 G4 box; other site 394503005119 G5 box; other site 394503005120 G1 box; other site 394503005121 Switch I region; other site 394503005122 G2 box; other site 394503005123 G3 box; other site 394503005124 Switch II region; other site 394503005125 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 394503005126 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 394503005127 substrate binding site [chemical binding]; other site 394503005128 hexamer interface [polypeptide binding]; other site 394503005129 metal binding site [ion binding]; metal-binding site 394503005130 Thiamine pyrophosphokinase; Region: TPK; cd07995 394503005131 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 394503005132 active site 394503005133 dimerization interface [polypeptide binding]; other site 394503005134 thiamine binding site [chemical binding]; other site 394503005135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503005136 Coenzyme A binding pocket [chemical binding]; other site 394503005137 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 394503005138 active site 394503005139 DNA binding site [nucleotide binding] 394503005140 Transposase, Mutator family; Region: Transposase_mut; pfam00872 394503005141 MULE transposase domain; Region: MULE; pfam10551 394503005142 Thrombospondin C-terminal region; Region: TSP_C; pfam05735 394503005143 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 394503005144 dockerin binding interface; other site 394503005145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503005146 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503005147 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503005148 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 394503005149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503005150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503005151 dimer interface [polypeptide binding]; other site 394503005152 phosphorylation site [posttranslational modification] 394503005153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503005154 ATP binding site [chemical binding]; other site 394503005155 Mg2+ binding site [ion binding]; other site 394503005156 G-X-G motif; other site 394503005157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503005158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503005159 active site 394503005160 phosphorylation site [posttranslational modification] 394503005161 intermolecular recognition site; other site 394503005162 dimerization interface [polypeptide binding]; other site 394503005163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503005164 DNA binding site [nucleotide binding] 394503005165 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005166 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005167 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005168 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005169 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 394503005170 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005171 Bacterial Ig-like domain; Region: Big_5; pfam13205 394503005172 S-layer homology domain; Region: SLH; pfam00395 394503005173 Cupin domain; Region: Cupin_2; pfam07883 394503005174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503005175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503005176 Right handed beta helix region; Region: Beta_helix; pfam13229 394503005177 Glyco_18 domain; Region: Glyco_18; smart00636 394503005178 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 394503005179 active site 394503005180 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005181 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 394503005182 putative metal binding site [ion binding]; other site 394503005183 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 394503005184 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005185 Uncharacterized conserved protein [Function unknown]; Region: COG3339 394503005186 Lamin Tail Domain; Region: LTD; pfam00932 394503005187 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 394503005188 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 394503005189 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 394503005190 active site 394503005191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503005192 dimerization interface [polypeptide binding]; other site 394503005193 putative DNA binding site [nucleotide binding]; other site 394503005194 putative Zn2+ binding site [ion binding]; other site 394503005195 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 394503005196 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 394503005197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503005198 putative transposase OrfB; Reviewed; Region: PHA02517 394503005199 HTH-like domain; Region: HTH_21; pfam13276 394503005200 Integrase core domain; Region: rve; pfam00665 394503005201 Integrase core domain; Region: rve_3; pfam13683 394503005202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005203 Transposase; Region: HTH_Tnp_1; pfam01527 394503005204 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503005205 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 394503005206 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 394503005207 Lysozyme subfamily 2; Region: LYZ2; smart00047 394503005208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503005209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503005210 non-specific DNA binding site [nucleotide binding]; other site 394503005211 salt bridge; other site 394503005212 sequence-specific DNA binding site [nucleotide binding]; other site 394503005213 Replication initiation factor; Region: Rep_trans; pfam02486 394503005214 Zonular occludens toxin (Zot); Region: Zot; cl17485 394503005215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503005216 HTH-like domain; Region: HTH_21; pfam13276 394503005217 Integrase core domain; Region: rve; pfam00665 394503005218 Integrase core domain; Region: rve_2; pfam13333 394503005219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005220 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503005221 Transposase; Region: HTH_Tnp_1; cl17663 394503005222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503005223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503005224 non-specific DNA binding site [nucleotide binding]; other site 394503005225 salt bridge; other site 394503005226 sequence-specific DNA binding site [nucleotide binding]; other site 394503005227 Replication initiation factor; Region: Rep_trans; pfam02486 394503005228 Zonular occludens toxin (Zot); Region: Zot; cl17485 394503005229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503005230 HTH-like domain; Region: HTH_21; pfam13276 394503005231 Integrase core domain; Region: rve; pfam00665 394503005232 Integrase core domain; Region: rve_2; pfam13333 394503005233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005234 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503005235 Transposase; Region: HTH_Tnp_1; cl17663 394503005236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503005237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503005238 non-specific DNA binding site [nucleotide binding]; other site 394503005239 salt bridge; other site 394503005240 sequence-specific DNA binding site [nucleotide binding]; other site 394503005241 Replication initiation factor; Region: Rep_trans; pfam02486 394503005242 Zonular occludens toxin (Zot); Region: Zot; cl17485 394503005243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503005244 HTH-like domain; Region: HTH_21; pfam13276 394503005245 Integrase core domain; Region: rve; pfam00665 394503005246 Integrase core domain; Region: rve_2; pfam13333 394503005247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005248 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503005249 Transposase; Region: HTH_Tnp_1; cl17663 394503005250 alpha-galactosidase; Region: PLN02808; cl17638 394503005251 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005252 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005253 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 394503005254 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 394503005255 GTP binding site; other site 394503005256 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 394503005257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503005258 dimer interface [polypeptide binding]; other site 394503005259 conserved gate region; other site 394503005260 putative PBP binding loops; other site 394503005261 ABC-ATPase subunit interface; other site 394503005262 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 394503005263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 394503005264 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 394503005265 MPT binding site; other site 394503005266 trimer interface [polypeptide binding]; other site 394503005267 MOSC domain; Region: MOSC; pfam03473 394503005268 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 394503005269 trimer interface [polypeptide binding]; other site 394503005270 dimer interface [polypeptide binding]; other site 394503005271 putative active site [active] 394503005272 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 394503005273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005274 FeS/SAM binding site; other site 394503005275 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 394503005276 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 394503005277 Walker A motif; other site 394503005278 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 394503005279 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 394503005280 dimer interface [polypeptide binding]; other site 394503005281 putative functional site; other site 394503005282 putative MPT binding site; other site 394503005283 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 394503005284 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503005285 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 394503005286 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 394503005287 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 394503005288 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 394503005289 Ligand binding site [chemical binding]; other site 394503005290 Electron transfer flavoprotein domain; Region: ETF; pfam01012 394503005291 MarR family; Region: MarR_2; pfam12802 394503005292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 394503005293 Radical SAM superfamily; Region: Radical_SAM; pfam04055 394503005294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005295 FeS/SAM binding site; other site 394503005296 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 394503005297 dihydrodipicolinate synthase; Region: dapA; TIGR00674 394503005298 dimer interface [polypeptide binding]; other site 394503005299 active site 394503005300 catalytic residue [active] 394503005301 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503005302 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 394503005303 inhibitor-cofactor binding pocket; inhibition site 394503005304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503005305 catalytic residue [active] 394503005306 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 394503005307 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 394503005308 Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972 394503005309 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 394503005310 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 394503005311 Nitrogenase subunit NifH (ATPase) [Inorganic ion transport and metabolism]; Region: NifH; COG1348 394503005312 Nucleotide-binding sites [chemical binding]; other site 394503005313 Walker A motif; other site 394503005314 Switch I region of nucleotide binding site; other site 394503005315 Fe4S4 binding sites [ion binding]; other site 394503005316 Switch II region of nucleotide binding site; other site 394503005317 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 394503005318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503005319 Coenzyme A binding pocket [chemical binding]; other site 394503005320 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 394503005321 Chorismate mutase type II; Region: CM_2; cl00693 394503005322 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 394503005323 Prephenate dehydratase; Region: PDT; pfam00800 394503005324 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 394503005325 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 394503005326 substrate binding site [chemical binding]; other site 394503005327 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 394503005328 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 394503005329 substrate binding site [chemical binding]; other site 394503005330 ligand binding site [chemical binding]; other site 394503005331 Cupin domain; Region: Cupin_2; pfam07883 394503005332 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 394503005333 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 394503005334 active site 394503005335 catalytic residues [active] 394503005336 metal binding site [ion binding]; metal-binding site 394503005337 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 394503005338 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 394503005339 active site 394503005340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503005341 AMP-binding enzyme; Region: AMP-binding; pfam00501 394503005342 acyl-activating enzyme (AAE) consensus motif; other site 394503005343 active site 394503005344 AMP binding site [chemical binding]; other site 394503005345 CoA binding site [chemical binding]; other site 394503005346 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 394503005347 active site 394503005348 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 394503005349 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 394503005350 Ligand Binding Site [chemical binding]; other site 394503005351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503005352 dimer interface [polypeptide binding]; other site 394503005353 conserved gate region; other site 394503005354 ABC-ATPase subunit interface; other site 394503005355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 394503005356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503005357 dimer interface [polypeptide binding]; other site 394503005358 conserved gate region; other site 394503005359 putative PBP binding loops; other site 394503005360 ABC-ATPase subunit interface; other site 394503005361 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 394503005362 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 394503005363 Walker A/P-loop; other site 394503005364 ATP binding site [chemical binding]; other site 394503005365 Q-loop/lid; other site 394503005366 ABC transporter signature motif; other site 394503005367 Walker B; other site 394503005368 D-loop; other site 394503005369 H-loop/switch region; other site 394503005370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 394503005371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 394503005372 substrate binding pocket [chemical binding]; other site 394503005373 membrane-bound complex binding site; other site 394503005374 hinge residues; other site 394503005375 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 394503005376 4Fe-4S binding domain; Region: Fer4_6; pfam12837 394503005377 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 394503005378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 394503005379 molybdopterin cofactor binding site; other site 394503005380 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 394503005381 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 394503005382 molybdopterin cofactor binding site; other site 394503005383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 394503005384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 394503005385 substrate binding pocket [chemical binding]; other site 394503005386 membrane-bound complex binding site; other site 394503005387 hinge residues; other site 394503005388 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 394503005389 DAK2 domain; Region: Dak2; pfam02734 394503005390 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 394503005391 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 394503005392 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 394503005393 short chain dehydrogenase; Provisional; Region: PRK06841 394503005394 classical (c) SDRs; Region: SDR_c; cd05233 394503005395 NAD(P) binding site [chemical binding]; other site 394503005396 active site 394503005397 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 394503005398 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 394503005399 putative ligand binding site [chemical binding]; other site 394503005400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503005401 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503005402 TM-ABC transporter signature motif; other site 394503005403 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 394503005404 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503005405 Walker A/P-loop; other site 394503005406 ATP binding site [chemical binding]; other site 394503005407 Q-loop/lid; other site 394503005408 ABC transporter signature motif; other site 394503005409 Walker B; other site 394503005410 D-loop; other site 394503005411 H-loop/switch region; other site 394503005412 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503005413 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 394503005414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503005415 active site 394503005416 phosphorylation site [posttranslational modification] 394503005417 intermolecular recognition site; other site 394503005418 dimerization interface [polypeptide binding]; other site 394503005419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503005420 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 394503005421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503005422 dimerization interface [polypeptide binding]; other site 394503005423 Histidine kinase; Region: His_kinase; pfam06580 394503005424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503005425 ATP binding site [chemical binding]; other site 394503005426 Mg2+ binding site [ion binding]; other site 394503005427 G-X-G motif; other site 394503005428 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 394503005429 endoglucanase; Region: PLN02420 394503005430 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503005431 Cellulose binding domain; Region: CBM_3; cl03026 394503005432 Cellulose binding domain; Region: CBM_3; pfam00942 394503005433 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005434 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 394503005436 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 394503005437 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 394503005438 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 394503005439 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 394503005440 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 394503005441 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 394503005442 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 394503005443 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503005444 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503005445 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 394503005446 putative active site [active] 394503005447 putative metal binding site [ion binding]; other site 394503005448 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 394503005449 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 394503005450 active site 394503005451 DNA binding site [nucleotide binding] 394503005452 Int/Topo IB signature motif; other site 394503005453 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005454 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 394503005455 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 394503005456 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 394503005457 metal binding site [ion binding]; metal-binding site 394503005458 ligand binding site [chemical binding]; other site 394503005459 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005460 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005461 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 394503005462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503005463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503005464 active site 394503005465 phosphorylation site [posttranslational modification] 394503005466 intermolecular recognition site; other site 394503005467 dimerization interface [polypeptide binding]; other site 394503005468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503005469 DNA binding site [nucleotide binding] 394503005470 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 394503005471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503005472 dimerization interface [polypeptide binding]; other site 394503005473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503005474 dimer interface [polypeptide binding]; other site 394503005475 phosphorylation site [posttranslational modification] 394503005476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503005477 ATP binding site [chemical binding]; other site 394503005478 Mg2+ binding site [ion binding]; other site 394503005479 G-X-G motif; other site 394503005480 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 394503005481 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 394503005482 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 394503005483 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 394503005484 catalytic residues [active] 394503005485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503005486 putative substrate translocation pore; other site 394503005487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 394503005488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 394503005489 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 394503005490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005491 FeS/SAM binding site; other site 394503005492 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 394503005493 Transposase; Region: HTH_Tnp_1; pfam01527 394503005494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503005495 putative transposase OrfB; Reviewed; Region: PHA02517 394503005496 HTH-like domain; Region: HTH_21; pfam13276 394503005497 Integrase core domain; Region: rve; pfam00665 394503005498 Integrase core domain; Region: rve_3; pfam13683 394503005499 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503005500 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503005501 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 394503005502 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 394503005503 beta-D-glucuronidase; Provisional; Region: PRK10150 394503005504 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 394503005505 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 394503005506 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 394503005507 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 394503005508 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503005509 substrate binding site [chemical binding]; other site 394503005510 ATP binding site [chemical binding]; other site 394503005511 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 394503005512 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 394503005513 active site 394503005514 intersubunit interface [polypeptide binding]; other site 394503005515 catalytic residue [active] 394503005516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 394503005517 active site 394503005518 D-mannonate oxidoreductase; Provisional; Region: PRK08277 394503005519 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 394503005520 putative NAD(P) binding site [chemical binding]; other site 394503005521 active site 394503005522 mannonate dehydratase; Provisional; Region: PRK03906 394503005523 mannonate dehydratase; Region: uxuA; TIGR00695 394503005524 MFS/sugar transport protein; Region: MFS_2; pfam13347 394503005525 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 394503005526 Glucuronate isomerase; Region: UxaC; pfam02614 394503005527 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 394503005528 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 394503005529 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 394503005530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 394503005531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 394503005532 ligand binding site [chemical binding]; other site 394503005533 flexible hinge region; other site 394503005534 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 394503005535 putative switch regulator; other site 394503005536 non-specific DNA interactions [nucleotide binding]; other site 394503005537 DNA binding site [nucleotide binding] 394503005538 sequence specific DNA binding site [nucleotide binding]; other site 394503005539 putative cAMP binding site [chemical binding]; other site 394503005540 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 394503005541 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 394503005542 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 394503005543 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 394503005544 dimer interface [polypeptide binding]; other site 394503005545 active site 394503005546 glycine-pyridoxal phosphate binding site [chemical binding]; other site 394503005547 folate binding site [chemical binding]; other site 394503005548 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 394503005549 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 394503005550 dimerization interface [polypeptide binding]; other site 394503005551 putative ATP binding site [chemical binding]; other site 394503005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 394503005553 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 394503005554 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 394503005555 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 394503005556 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 394503005557 Ligand Binding Site [chemical binding]; other site 394503005558 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 394503005559 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 394503005560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503005561 catalytic residue [active] 394503005562 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503005563 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 394503005564 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503005565 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 394503005566 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 394503005567 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 394503005568 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 394503005569 hydrogenase 4 subunit F; Validated; Region: PRK06458 394503005570 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 394503005571 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 394503005572 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 394503005573 NADH dehydrogenase; Region: NADHdh; cl00469 394503005574 hydrogenase 4 subunit B; Validated; Region: PRK06521 394503005575 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 394503005576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 394503005577 LexA repressor; Validated; Region: PRK00215 394503005578 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 394503005579 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 394503005580 Catalytic site [active] 394503005581 bacterial Hfq-like; Region: Hfq; cd01716 394503005582 hexamer interface [polypeptide binding]; other site 394503005583 Sm1 motif; other site 394503005584 RNA binding site [nucleotide binding]; other site 394503005585 Sm2 motif; other site 394503005586 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 394503005587 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 394503005588 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 394503005589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503005590 ATP binding site [chemical binding]; other site 394503005591 Mg2+ binding site [ion binding]; other site 394503005592 G-X-G motif; other site 394503005593 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 394503005594 ATP binding site [chemical binding]; other site 394503005595 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 394503005596 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 394503005597 MutS domain I; Region: MutS_I; pfam01624 394503005598 MutS domain II; Region: MutS_II; pfam05188 394503005599 MutS domain III; Region: MutS_III; pfam05192 394503005600 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 394503005601 Walker A/P-loop; other site 394503005602 ATP binding site [chemical binding]; other site 394503005603 Q-loop/lid; other site 394503005604 ABC transporter signature motif; other site 394503005605 Walker B; other site 394503005606 D-loop; other site 394503005607 H-loop/switch region; other site 394503005608 Protein of unknown function (DUF964); Region: DUF964; pfam06133 394503005609 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 394503005610 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 394503005611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005612 FeS/SAM binding site; other site 394503005613 TRAM domain; Region: TRAM; cl01282 394503005614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503005615 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 394503005616 Coenzyme A binding pocket [chemical binding]; other site 394503005617 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 394503005618 CoenzymeA binding site [chemical binding]; other site 394503005619 subunit interaction site [polypeptide binding]; other site 394503005620 PHB binding site; other site 394503005621 YlzJ-like protein; Region: YlzJ; pfam14035 394503005622 Clp protease; Region: CLP_protease; pfam00574 394503005623 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 394503005624 active site 394503005625 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 394503005626 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 394503005627 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 394503005628 NAD binding site [chemical binding]; other site 394503005629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 394503005630 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 394503005631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 394503005632 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 394503005633 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 394503005634 RNase E interface [polypeptide binding]; other site 394503005635 trimer interface [polypeptide binding]; other site 394503005636 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 394503005637 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 394503005638 RNase E interface [polypeptide binding]; other site 394503005639 trimer interface [polypeptide binding]; other site 394503005640 active site 394503005641 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 394503005642 putative nucleic acid binding region [nucleotide binding]; other site 394503005643 G-X-X-G motif; other site 394503005644 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 394503005645 RNA binding site [nucleotide binding]; other site 394503005646 domain interface; other site 394503005647 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 394503005648 16S/18S rRNA binding site [nucleotide binding]; other site 394503005649 S13e-L30e interaction site [polypeptide binding]; other site 394503005650 25S rRNA binding site [nucleotide binding]; other site 394503005651 MoxR-like ATPases [General function prediction only]; Region: COG0714 394503005652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503005653 Walker A motif; other site 394503005654 ATP binding site [chemical binding]; other site 394503005655 Walker B motif; other site 394503005656 arginine finger; other site 394503005657 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 394503005658 Protein of unknown function DUF58; Region: DUF58; pfam01882 394503005659 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 394503005660 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 394503005661 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 394503005662 EamA-like transporter family; Region: EamA; pfam00892 394503005663 EamA-like transporter family; Region: EamA; pfam00892 394503005664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503005665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503005666 dimerization interface [polypeptide binding]; other site 394503005667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503005668 dimer interface [polypeptide binding]; other site 394503005669 phosphorylation site [posttranslational modification] 394503005670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503005671 ATP binding site [chemical binding]; other site 394503005672 Mg2+ binding site [ion binding]; other site 394503005673 G-X-G motif; other site 394503005674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503005675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503005676 active site 394503005677 phosphorylation site [posttranslational modification] 394503005678 intermolecular recognition site; other site 394503005679 dimerization interface [polypeptide binding]; other site 394503005680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503005681 DNA binding site [nucleotide binding] 394503005682 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 394503005683 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 394503005684 metal-binding site [ion binding] 394503005685 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 394503005686 Transcriptional regulator [Transcription]; Region: LytR; COG1316 394503005687 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503005688 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503005689 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 394503005690 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 394503005691 protein binding site [polypeptide binding]; other site 394503005692 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 394503005693 Predicted amidohydrolase [General function prediction only]; Region: COG0388 394503005694 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 394503005695 putative active site [active] 394503005696 catalytic triad [active] 394503005697 dimer interface [polypeptide binding]; other site 394503005698 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 394503005699 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 394503005700 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 394503005701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503005702 FeS/SAM binding site; other site 394503005703 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 394503005704 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 394503005705 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503005706 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503005707 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 394503005708 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 394503005709 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 394503005710 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 394503005711 LytB protein; Region: LYTB; cl00507 394503005712 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 394503005713 RNA binding site [nucleotide binding]; other site 394503005714 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 394503005715 RNA binding site [nucleotide binding]; other site 394503005716 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 394503005717 RNA binding site [nucleotide binding]; other site 394503005718 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 394503005719 RNA binding site [nucleotide binding]; other site 394503005720 cytidylate kinase; Provisional; Region: cmk; PRK00023 394503005721 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 394503005722 CMP-binding site; other site 394503005723 The sites determining sugar specificity; other site 394503005724 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 394503005725 homotrimer interaction site [polypeptide binding]; other site 394503005726 active site 394503005727 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 394503005728 hexamer interface [polypeptide binding]; other site 394503005729 RNA binding site [nucleotide binding]; other site 394503005730 Histidine-zinc binding site [chemical binding]; other site 394503005731 flavoprotein, HI0933 family; Region: TIGR00275 394503005732 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 394503005733 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 394503005734 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 394503005735 putative active site [active] 394503005736 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 394503005737 oxaloacetate decarboxylase; Provisional; Region: PRK12331 394503005738 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 394503005739 active site 394503005740 catalytic residues [active] 394503005741 metal binding site [ion binding]; metal-binding site 394503005742 homodimer binding site [polypeptide binding]; other site 394503005743 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 394503005744 carboxyltransferase (CT) interaction site; other site 394503005745 biotinylation site [posttranslational modification]; other site 394503005746 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 394503005747 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 394503005748 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 394503005749 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 394503005750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503005751 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 394503005752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 394503005753 S-adenosylmethionine binding site [chemical binding]; other site 394503005754 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 394503005755 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 394503005756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503005757 RNA binding surface [nucleotide binding]; other site 394503005758 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 394503005759 active site 394503005760 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 394503005761 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 394503005762 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 394503005763 ScpA/B protein; Region: ScpA_ScpB; cl00598 394503005764 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 394503005765 Peptidase family M50; Region: Peptidase_M50; pfam02163 394503005766 active site 394503005767 putative substrate binding region [chemical binding]; other site 394503005768 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 394503005769 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 394503005770 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 394503005771 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 394503005772 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 394503005773 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 394503005774 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 394503005775 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 394503005776 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 394503005777 active site 394503005778 Int/Topo IB signature motif; other site 394503005779 Integral membrane protein DUF95; Region: DUF95; cl00572 394503005780 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 394503005781 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 394503005782 dimer interface [polypeptide binding]; other site 394503005783 ADP-ribose binding site [chemical binding]; other site 394503005784 active site 394503005785 nudix motif; other site 394503005786 metal binding site [ion binding]; metal-binding site 394503005787 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 394503005788 RNA/DNA hybrid binding site [nucleotide binding]; other site 394503005789 active site 394503005790 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 394503005791 pyrroline-5-carboxylate reductase; Region: PLN02688 394503005792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503005793 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 394503005794 acyl-activating enzyme (AAE) consensus motif; other site 394503005795 AMP binding site [chemical binding]; other site 394503005796 active site 394503005797 CoA binding site [chemical binding]; other site 394503005798 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 394503005799 L-lactate permease; Region: Lactate_perm; cl00701 394503005800 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 394503005801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 394503005802 Beta-Casp domain; Region: Beta-Casp; smart01027 394503005803 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 394503005804 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 394503005805 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 394503005806 oligomer interface [polypeptide binding]; other site 394503005807 active site 394503005808 metal binding site [ion binding]; metal-binding site 394503005809 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 394503005810 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 394503005811 oligomer interface [polypeptide binding]; other site 394503005812 active site 394503005813 metal binding site [ion binding]; metal-binding site 394503005814 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 394503005815 oligomer interface [polypeptide binding]; other site 394503005816 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 394503005817 active site 394503005818 metal binding site [ion binding]; metal-binding site 394503005819 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 394503005820 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 394503005821 Walker A/P-loop; other site 394503005822 ATP binding site [chemical binding]; other site 394503005823 Q-loop/lid; other site 394503005824 ABC transporter signature motif; other site 394503005825 Walker B; other site 394503005826 D-loop; other site 394503005827 H-loop/switch region; other site 394503005828 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 394503005829 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 394503005830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 394503005831 Walker A/P-loop; other site 394503005832 ATP binding site [chemical binding]; other site 394503005833 Q-loop/lid; other site 394503005834 ABC transporter signature motif; other site 394503005835 Walker B; other site 394503005836 D-loop; other site 394503005837 H-loop/switch region; other site 394503005838 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 394503005839 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 394503005840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 394503005841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503005842 dimer interface [polypeptide binding]; other site 394503005843 conserved gate region; other site 394503005844 putative PBP binding loops; other site 394503005845 ABC-ATPase subunit interface; other site 394503005846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 394503005847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503005848 dimer interface [polypeptide binding]; other site 394503005849 conserved gate region; other site 394503005850 putative PBP binding loops; other site 394503005851 ABC-ATPase subunit interface; other site 394503005852 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 394503005853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 394503005854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503005855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503005857 Walker A/P-loop; other site 394503005858 ATP binding site [chemical binding]; other site 394503005859 Q-loop/lid; other site 394503005860 ABC transporter signature motif; other site 394503005861 Walker B; other site 394503005862 D-loop; other site 394503005863 H-loop/switch region; other site 394503005864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503005865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503005866 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 394503005867 Walker A/P-loop; other site 394503005868 ATP binding site [chemical binding]; other site 394503005869 Q-loop/lid; other site 394503005870 ABC transporter signature motif; other site 394503005871 Walker B; other site 394503005872 D-loop; other site 394503005873 H-loop/switch region; other site 394503005874 hypothetical protein; Provisional; Region: PRK13670 394503005875 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 394503005876 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 394503005877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 394503005878 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 394503005879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 394503005880 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 394503005881 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 394503005882 Family description; Region: UvrD_C_2; pfam13538 394503005883 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 394503005884 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 394503005885 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 394503005886 CAAX protease self-immunity; Region: Abi; pfam02517 394503005887 CoA binding domain; Region: CoA_binding_2; pfam13380 394503005888 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 394503005889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 394503005890 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 394503005891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 394503005892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 394503005893 FOG: CBS domain [General function prediction only]; Region: COG0517 394503005894 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 394503005895 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 394503005896 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 394503005897 DNA binding residues [nucleotide binding] 394503005898 dimer interface [polypeptide binding]; other site 394503005899 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 394503005900 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 394503005901 dinuclear metal binding motif [ion binding]; other site 394503005902 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 394503005903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 394503005904 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503005905 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 394503005906 tetramerization interface [polypeptide binding]; other site 394503005907 active site 394503005908 Pantoate-beta-alanine ligase; Region: PanC; cd00560 394503005909 pantoate--beta-alanine ligase; Region: panC; TIGR00018 394503005910 active site 394503005911 ATP-binding site [chemical binding]; other site 394503005912 pantoate-binding site; other site 394503005913 HXXH motif; other site 394503005914 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 394503005915 oligomerization interface [polypeptide binding]; other site 394503005916 active site 394503005917 metal binding site [ion binding]; metal-binding site 394503005918 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 394503005919 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 394503005920 glycyl-tRNA synthetase; Provisional; Region: PRK04173 394503005921 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 394503005922 motif 1; other site 394503005923 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 394503005924 active site 394503005925 motif 2; other site 394503005926 motif 3; other site 394503005927 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 394503005928 anticodon binding site; other site 394503005929 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 394503005930 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 394503005931 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 394503005932 catalytic site [active] 394503005933 G-X2-G-X-G-K; other site 394503005934 hypothetical protein; Provisional; Region: PRK04323 394503005935 hypothetical protein; Provisional; Region: PRK11820 394503005936 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 394503005937 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 394503005938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503005939 Response regulator receiver domain; Region: Response_reg; pfam00072 394503005940 active site 394503005941 phosphorylation site [posttranslational modification] 394503005942 intermolecular recognition site; other site 394503005943 dimerization interface [polypeptide binding]; other site 394503005944 RNA methyltransferase, RsmE family; Region: TIGR00046 394503005945 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 394503005946 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 394503005947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503005948 S-adenosylmethionine binding site [chemical binding]; other site 394503005949 chaperone protein DnaJ; Provisional; Region: PRK14277 394503005950 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 394503005951 HSP70 interaction site [polypeptide binding]; other site 394503005952 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 394503005953 substrate binding site [polypeptide binding]; other site 394503005954 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 394503005955 Zn binding sites [ion binding]; other site 394503005956 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 394503005957 dimer interface [polypeptide binding]; other site 394503005958 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 394503005959 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 394503005960 nucleotide binding site [chemical binding]; other site 394503005961 NEF interaction site [polypeptide binding]; other site 394503005962 SBD interface [polypeptide binding]; other site 394503005963 GrpE; Region: GrpE; pfam01025 394503005964 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 394503005965 dimer interface [polypeptide binding]; other site 394503005966 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 394503005967 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 394503005968 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 394503005969 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 394503005970 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 394503005971 homodimer interface [polypeptide binding]; other site 394503005972 substrate-cofactor binding pocket; other site 394503005973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503005974 catalytic residue [active] 394503005975 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503005976 Zn2+ binding site [ion binding]; other site 394503005977 Mg2+ binding site [ion binding]; other site 394503005978 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 394503005979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503005980 Zn2+ binding site [ion binding]; other site 394503005981 Mg2+ binding site [ion binding]; other site 394503005982 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 394503005983 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 394503005984 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 394503005985 Sulfatase; Region: Sulfatase; cl17466 394503005986 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 394503005987 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503005988 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 394503005989 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 394503005990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503005991 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503005992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503005993 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503005994 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 394503005995 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 394503005996 active site 394503005997 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 394503005998 putative catalytic site [active] 394503005999 putative metal binding site [ion binding]; other site 394503006000 putative phosphate binding site [ion binding]; other site 394503006001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 394503006002 active site 394503006003 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 394503006004 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503006005 inhibitor-cofactor binding pocket; inhibition site 394503006006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503006007 catalytic residue [active] 394503006008 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 394503006009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503006010 NAD(P) binding site [chemical binding]; other site 394503006011 active site 394503006012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 394503006013 active site 394503006014 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 394503006015 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 394503006016 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 394503006017 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 394503006018 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503006019 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503006020 Winged helix-turn helix; Region: HTH_29; pfam13551 394503006021 Homeodomain-like domain; Region: HTH_32; pfam13565 394503006022 Integrase core domain; Region: rve; pfam00665 394503006023 Integrase core domain; Region: rve_3; pfam13683 394503006024 putative transposase OrfB; Reviewed; Region: PHA02517 394503006025 HTH-like domain; Region: HTH_21; pfam13276 394503006026 Integrase core domain; Region: rve; pfam00665 394503006027 Integrase core domain; Region: rve_3; pfam13683 394503006028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503006029 Transposase; Region: HTH_Tnp_1; pfam01527 394503006030 Helix-turn-helix domain; Region: HTH_17; cl17695 394503006031 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 394503006032 Dimer interface [polypeptide binding]; other site 394503006033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503006034 Transposase; Region: HTH_Tnp_1; pfam01527 394503006035 putative transposase OrfB; Reviewed; Region: PHA02517 394503006036 HTH-like domain; Region: HTH_21; pfam13276 394503006037 Integrase core domain; Region: rve; pfam00665 394503006038 Integrase core domain; Region: rve_3; pfam13683 394503006039 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 394503006040 synthetase active site [active] 394503006041 NTP binding site [chemical binding]; other site 394503006042 metal binding site [ion binding]; metal-binding site 394503006043 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503006044 Winged helix-turn helix; Region: HTH_29; pfam13551 394503006045 Homeodomain-like domain; Region: HTH_32; pfam13565 394503006046 Integrase core domain; Region: rve; pfam00665 394503006047 Integrase core domain; Region: rve_3; pfam13683 394503006048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503006049 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 394503006050 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 394503006051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503006052 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 394503006053 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 394503006054 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 394503006055 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 394503006056 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 394503006057 active site 394503006058 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503006059 Winged helix-turn helix; Region: HTH_29; pfam13551 394503006060 Homeodomain-like domain; Region: HTH_32; pfam13565 394503006061 Integrase core domain; Region: rve; pfam00665 394503006062 Integrase core domain; Region: rve_3; pfam13683 394503006063 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 394503006064 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503006065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503006066 Helix-turn-helix domain; Region: HTH_36; pfam13730 394503006067 Helix-turn-helix domain; Region: HTH_17; pfam12728 394503006068 Helix-turn-helix domain; Region: HTH_17; pfam12728 394503006069 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 394503006070 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 394503006071 Int/Topo IB signature motif; other site 394503006072 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503006073 Winged helix-turn helix; Region: HTH_29; pfam13551 394503006074 Homeodomain-like domain; Region: HTH_32; pfam13565 394503006075 Integrase core domain; Region: rve; pfam00665 394503006076 Integrase core domain; Region: rve_3; pfam13683 394503006077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503006078 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 394503006079 active site 394503006080 motif I; other site 394503006081 motif II; other site 394503006082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 394503006083 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 394503006084 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 394503006085 active site 394503006086 dimer interface [polypeptide binding]; other site 394503006087 metal binding site [ion binding]; metal-binding site 394503006088 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 394503006089 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 394503006090 HIGH motif; other site 394503006091 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 394503006092 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 394503006093 active site 394503006094 KMSKS motif; other site 394503006095 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 394503006096 tRNA binding surface [nucleotide binding]; other site 394503006097 anticodon binding site; other site 394503006098 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 394503006099 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 394503006100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503006101 DNA-binding site [nucleotide binding]; DNA binding site 394503006102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503006103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503006104 homodimer interface [polypeptide binding]; other site 394503006105 catalytic residue [active] 394503006106 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 394503006107 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 394503006108 active site 394503006109 multimer interface [polypeptide binding]; other site 394503006110 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 394503006111 predicted active site [active] 394503006112 catalytic triad [active] 394503006113 Rhomboid family; Region: Rhomboid; pfam01694 394503006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503006115 TPR motif; other site 394503006116 binding surface 394503006117 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 394503006118 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 394503006119 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 394503006120 AMP-binding domain protein; Validated; Region: PRK08315 394503006121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503006122 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 394503006123 acyl-activating enzyme (AAE) consensus motif; other site 394503006124 acyl-activating enzyme (AAE) consensus motif; other site 394503006125 putative AMP binding site [chemical binding]; other site 394503006126 putative active site [active] 394503006127 putative CoA binding site [chemical binding]; other site 394503006128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 394503006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006130 active site 394503006131 phosphorylation site [posttranslational modification] 394503006132 intermolecular recognition site; other site 394503006133 dimerization interface [polypeptide binding]; other site 394503006134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 394503006135 DNA binding residues [nucleotide binding] 394503006136 dimerization interface [polypeptide binding]; other site 394503006137 Sensor protein DegS; Region: DegS; pfam05384 394503006138 Histidine kinase; Region: HisKA_3; pfam07730 394503006139 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 394503006140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006141 ATP binding site [chemical binding]; other site 394503006142 Mg2+ binding site [ion binding]; other site 394503006143 G-X-G motif; other site 394503006144 Uncharacterized conserved protein [Function unknown]; Region: COG1262 394503006145 Brevenin/esculentin/gaegurin/rugosin family; Region: Brevenin; pfam03032 394503006146 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 394503006147 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 394503006148 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 394503006149 GIY-YIG motif/motif A; other site 394503006150 putative active site [active] 394503006151 putative metal binding site [ion binding]; other site 394503006152 Putative cyclase; Region: Cyclase; pfam04199 394503006153 Rubrerythrin [Energy production and conversion]; Region: COG1592 394503006154 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 394503006155 binuclear metal center [ion binding]; other site 394503006156 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 394503006157 iron binding site [ion binding]; other site 394503006158 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 394503006159 NAD-dependent deacetylase; Provisional; Region: PRK00481 394503006160 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 394503006161 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 394503006162 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 394503006163 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 394503006164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503006165 catalytic residue [active] 394503006166 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 394503006167 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 394503006168 homodimer interface [polypeptide binding]; other site 394503006169 substrate-cofactor binding pocket; other site 394503006170 catalytic residue [active] 394503006171 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 394503006172 Nucleoside recognition; Region: Gate; pfam07670 394503006173 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 394503006174 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 394503006175 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 394503006176 active site 394503006177 (T/H)XGH motif; other site 394503006178 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 394503006179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503006180 S-adenosylmethionine binding site [chemical binding]; other site 394503006181 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 394503006182 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 394503006183 ssDNA binding site; other site 394503006184 generic binding surface II; other site 394503006185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503006186 ATP binding site [chemical binding]; other site 394503006187 putative Mg++ binding site [ion binding]; other site 394503006188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503006189 nucleotide binding region [chemical binding]; other site 394503006190 ATP-binding site [chemical binding]; other site 394503006191 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 394503006192 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 394503006193 GAF domain; Region: GAF_3; pfam13492 394503006194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 394503006195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 394503006196 metal binding site [ion binding]; metal-binding site 394503006197 active site 394503006198 I-site; other site 394503006199 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 394503006200 Cell division protein FtsA; Region: FtsA; smart00842 394503006201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 394503006202 nucleotide binding site [chemical binding]; other site 394503006203 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 394503006204 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 394503006205 minor groove reading motif; other site 394503006206 helix-hairpin-helix signature motif; other site 394503006207 substrate binding pocket [chemical binding]; other site 394503006208 active site 394503006209 glycogen synthase; Provisional; Region: glgA; PRK00654 394503006210 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 394503006211 ADP-binding pocket [chemical binding]; other site 394503006212 homodimer interface [polypeptide binding]; other site 394503006213 GAF domain; Region: GAF_3; pfam13492 394503006214 GAF domain; Region: GAF_2; pfam13185 394503006215 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 394503006216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503006217 Zn2+ binding site [ion binding]; other site 394503006218 Mg2+ binding site [ion binding]; other site 394503006219 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 394503006220 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 394503006221 protein binding site [polypeptide binding]; other site 394503006222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503006223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503006224 dimerization interface [polypeptide binding]; other site 394503006225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503006226 dimer interface [polypeptide binding]; other site 394503006227 phosphorylation site [posttranslational modification] 394503006228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006229 ATP binding site [chemical binding]; other site 394503006230 Mg2+ binding site [ion binding]; other site 394503006231 G-X-G motif; other site 394503006232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503006233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006234 active site 394503006235 phosphorylation site [posttranslational modification] 394503006236 intermolecular recognition site; other site 394503006237 dimerization interface [polypeptide binding]; other site 394503006238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503006239 DNA binding site [nucleotide binding] 394503006240 Bacterial SH3 domain; Region: SH3_3; cl17532 394503006241 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 394503006242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006243 active site 394503006244 phosphorylation site [posttranslational modification] 394503006245 intermolecular recognition site; other site 394503006246 dimerization interface [polypeptide binding]; other site 394503006247 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 394503006248 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 394503006249 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 394503006250 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 394503006251 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 394503006252 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 394503006253 Walker A/P-loop; other site 394503006254 ATP binding site [chemical binding]; other site 394503006255 Q-loop/lid; other site 394503006256 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 394503006257 ABC transporter signature motif; other site 394503006258 Walker B; other site 394503006259 D-loop; other site 394503006260 H-loop/switch region; other site 394503006261 arginine repressor; Provisional; Region: argR; PRK00441 394503006262 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 394503006263 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 394503006264 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 394503006265 ATP-NAD kinase; Region: NAD_kinase; pfam01513 394503006266 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 394503006267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503006268 RNA binding surface [nucleotide binding]; other site 394503006269 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 394503006270 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 394503006271 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 394503006272 TPP-binding site; other site 394503006273 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 394503006274 PYR/PP interface [polypeptide binding]; other site 394503006275 dimer interface [polypeptide binding]; other site 394503006276 TPP binding site [chemical binding]; other site 394503006277 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 394503006278 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 394503006279 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 394503006280 substrate binding pocket [chemical binding]; other site 394503006281 chain length determination region; other site 394503006282 substrate-Mg2+ binding site; other site 394503006283 catalytic residues [active] 394503006284 aspartate-rich region 1; other site 394503006285 active site lid residues [active] 394503006286 aspartate-rich region 2; other site 394503006287 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 394503006288 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 394503006289 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 394503006290 generic binding surface II; other site 394503006291 generic binding surface I; other site 394503006292 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 394503006293 putative RNA binding site [nucleotide binding]; other site 394503006294 Asp23 family; Region: Asp23; pfam03780 394503006295 Asp23 family; Region: Asp23; pfam03780 394503006296 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 394503006297 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 394503006298 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 394503006299 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 394503006300 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 394503006301 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 394503006302 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 394503006303 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 394503006304 NTPase; Region: NTPase_1; cl17478 394503006305 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 394503006306 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503006307 Walker A/P-loop; other site 394503006308 ATP binding site [chemical binding]; other site 394503006309 Q-loop/lid; other site 394503006310 ABC transporter signature motif; other site 394503006311 Walker B; other site 394503006312 D-loop; other site 394503006313 H-loop/switch region; other site 394503006314 Predicted transcriptional regulators [Transcription]; Region: COG1725 394503006315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503006316 DNA-binding site [nucleotide binding]; DNA binding site 394503006317 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 394503006318 elongation factor P; Validated; Region: PRK00529 394503006319 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 394503006320 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 394503006321 RNA binding site [nucleotide binding]; other site 394503006322 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 394503006323 RNA binding site [nucleotide binding]; other site 394503006324 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 394503006325 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 394503006326 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 394503006327 active site 394503006328 Dehydroquinase class II; Region: DHquinase_II; pfam01220 394503006329 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 394503006330 trimer interface [polypeptide binding]; other site 394503006331 active site 394503006332 dimer interface [polypeptide binding]; other site 394503006333 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 394503006334 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 394503006335 DNA interaction; other site 394503006336 Metal-binding active site; metal-binding site 394503006337 AP (apurinic/apyrimidinic) site pocket; other site 394503006338 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 394503006339 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 394503006340 oligomer interface [polypeptide binding]; other site 394503006341 putative active site [active] 394503006342 metal binding site [ion binding]; metal-binding site 394503006343 histidinol-phosphatase; Provisional; Region: PRK05588 394503006344 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 394503006345 active site 394503006346 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 394503006347 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 394503006348 Ligand Binding Site [chemical binding]; other site 394503006349 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 394503006350 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 394503006351 trimerization site [polypeptide binding]; other site 394503006352 active site 394503006353 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 394503006354 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 394503006355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 394503006356 catalytic residue [active] 394503006357 Predicted transcriptional regulator [Transcription]; Region: COG1959 394503006358 Transcriptional regulator; Region: Rrf2; cl17282 394503006359 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 394503006360 recombination factor protein RarA; Reviewed; Region: PRK13342 394503006361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503006362 Walker A motif; other site 394503006363 ATP binding site [chemical binding]; other site 394503006364 Walker B motif; other site 394503006365 arginine finger; other site 394503006366 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 394503006367 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503006368 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503006369 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 394503006370 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 394503006371 protein binding site [polypeptide binding]; other site 394503006372 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 394503006373 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 394503006374 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 394503006375 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 394503006376 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 394503006377 active site 394503006378 Substrate binding site; other site 394503006379 Mg++ binding site; other site 394503006380 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 394503006381 putative trimer interface [polypeptide binding]; other site 394503006382 putative CoA binding site [chemical binding]; other site 394503006383 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 394503006384 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 394503006385 GTP-binding protein LepA; Provisional; Region: PRK05433 394503006386 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 394503006387 G1 box; other site 394503006388 putative GEF interaction site [polypeptide binding]; other site 394503006389 GTP/Mg2+ binding site [chemical binding]; other site 394503006390 Switch I region; other site 394503006391 G2 box; other site 394503006392 G3 box; other site 394503006393 Switch II region; other site 394503006394 G4 box; other site 394503006395 G5 box; other site 394503006396 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 394503006397 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 394503006398 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 394503006399 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 394503006400 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 394503006401 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503006402 stage II sporulation protein P; Region: spore_II_P; TIGR02867 394503006403 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 394503006404 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 394503006405 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 394503006406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 394503006407 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 394503006408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 394503006409 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 394503006410 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 394503006411 dimer interface [polypeptide binding]; other site 394503006412 anticodon binding site; other site 394503006413 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 394503006414 homodimer interface [polypeptide binding]; other site 394503006415 motif 1; other site 394503006416 active site 394503006417 motif 2; other site 394503006418 GAD domain; Region: GAD; pfam02938 394503006419 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 394503006420 motif 3; other site 394503006421 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 394503006422 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 394503006423 dimer interface [polypeptide binding]; other site 394503006424 motif 1; other site 394503006425 active site 394503006426 motif 2; other site 394503006427 motif 3; other site 394503006428 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 394503006429 anticodon binding site; other site 394503006430 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 394503006431 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 394503006432 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 394503006433 putative active site [active] 394503006434 dimerization interface [polypeptide binding]; other site 394503006435 putative tRNAtyr binding site [nucleotide binding]; other site 394503006436 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 394503006437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503006438 Zn2+ binding site [ion binding]; other site 394503006439 Mg2+ binding site [ion binding]; other site 394503006440 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 394503006441 synthetase active site [active] 394503006442 NTP binding site [chemical binding]; other site 394503006443 metal binding site [ion binding]; metal-binding site 394503006444 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 394503006445 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 394503006446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503006447 active site 394503006448 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 394503006449 DHH family; Region: DHH; pfam01368 394503006450 DHHA1 domain; Region: DHHA1; pfam02272 394503006451 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 394503006452 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 394503006453 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 394503006454 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 394503006455 Competence protein; Region: Competence; pfam03772 394503006456 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 394503006457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 394503006458 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503006459 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503006460 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503006461 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503006462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 394503006463 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 394503006464 Transcriptional regulators [Transcription]; Region: MarR; COG1846 394503006465 MarR family; Region: MarR_2; pfam12802 394503006466 Predicted membrane protein [Function unknown]; Region: COG1511 394503006467 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 394503006468 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 394503006469 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 394503006470 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 394503006471 homodimer interface [polypeptide binding]; other site 394503006472 substrate-cofactor binding pocket; other site 394503006473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503006474 catalytic residue [active] 394503006475 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 394503006476 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503006477 putative DNA binding site [nucleotide binding]; other site 394503006478 putative Zn2+ binding site [ion binding]; other site 394503006479 AsnC family; Region: AsnC_trans_reg; pfam01037 394503006480 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 394503006481 Domain of unknown function (DUF814); Region: DUF814; pfam05670 394503006482 aspartate aminotransferase; Provisional; Region: PRK06836 394503006483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503006484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503006485 homodimer interface [polypeptide binding]; other site 394503006486 catalytic residue [active] 394503006487 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 394503006488 dimer interface [polypeptide binding]; other site 394503006489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 394503006490 Uncharacterized conserved protein [Function unknown]; Region: COG2006 394503006491 Domain of unknown function (DUF362); Region: DUF362; pfam04015 394503006492 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 394503006493 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 394503006494 Spore germination protein; Region: Spore_permease; cl17796 394503006495 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 394503006496 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 394503006497 active site 394503006498 Protein of unknown function, DUF624; Region: DUF624; pfam04854 394503006499 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 394503006500 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 394503006501 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 394503006502 nucleotide binding pocket [chemical binding]; other site 394503006503 K-X-D-G motif; other site 394503006504 catalytic site [active] 394503006505 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 394503006506 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 394503006507 Dimer interface [polypeptide binding]; other site 394503006508 BRCT sequence motif; other site 394503006509 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 394503006510 germination protease; Provisional; Region: PRK12362 394503006511 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 394503006512 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 394503006513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503006514 FeS/SAM binding site; other site 394503006515 HemN C-terminal domain; Region: HemN_C; pfam06969 394503006516 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 394503006517 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 394503006518 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 394503006519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006520 active site 394503006521 phosphorylation site [posttranslational modification] 394503006522 intermolecular recognition site; other site 394503006523 dimerization interface [polypeptide binding]; other site 394503006524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503006525 Cache domain; Region: Cache_1; pfam02743 394503006526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503006527 dimerization interface [polypeptide binding]; other site 394503006528 Histidine kinase; Region: His_kinase; pfam06580 394503006529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006530 ATP binding site [chemical binding]; other site 394503006531 Mg2+ binding site [ion binding]; other site 394503006532 G-X-G motif; other site 394503006533 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 394503006534 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 394503006535 ligand binding site [chemical binding]; other site 394503006536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503006537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503006538 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503006539 TM-ABC transporter signature motif; other site 394503006540 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 394503006541 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503006542 Walker A/P-loop; other site 394503006543 ATP binding site [chemical binding]; other site 394503006544 Q-loop/lid; other site 394503006545 ABC transporter signature motif; other site 394503006546 Walker B; other site 394503006547 D-loop; other site 394503006548 H-loop/switch region; other site 394503006549 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503006550 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 394503006551 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 394503006552 putative ligand binding site [chemical binding]; other site 394503006553 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 394503006554 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 394503006555 DXD motif; other site 394503006556 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 394503006557 thiamine phosphate binding site [chemical binding]; other site 394503006558 active site 394503006559 pyrophosphate binding site [ion binding]; other site 394503006560 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 394503006561 substrate binding site [chemical binding]; other site 394503006562 multimerization interface [polypeptide binding]; other site 394503006563 ATP binding site [chemical binding]; other site 394503006564 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 394503006565 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 394503006566 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 394503006567 dimer interface [polypeptide binding]; other site 394503006568 substrate binding site [chemical binding]; other site 394503006569 ATP binding site [chemical binding]; other site 394503006570 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 394503006571 ferric uptake regulator; Provisional; Region: fur; PRK09462 394503006572 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 394503006573 metal binding site 2 [ion binding]; metal-binding site 394503006574 putative DNA binding helix; other site 394503006575 metal binding site 1 [ion binding]; metal-binding site 394503006576 dimer interface [polypeptide binding]; other site 394503006577 structural Zn2+ binding site [ion binding]; other site 394503006578 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 394503006579 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 394503006580 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 394503006581 G1 box; other site 394503006582 GTP/Mg2+ binding site [chemical binding]; other site 394503006583 Switch I region; other site 394503006584 G2 box; other site 394503006585 G3 box; other site 394503006586 Switch II region; other site 394503006587 G4 box; other site 394503006588 G5 box; other site 394503006589 Nucleoside recognition; Region: Gate; pfam07670 394503006590 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 394503006591 Nucleoside recognition; Region: Gate; pfam07670 394503006592 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 394503006593 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085 394503006594 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 394503006595 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 394503006596 Cl binding site [ion binding]; other site 394503006597 oligomer interface [polypeptide binding]; other site 394503006598 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 394503006599 homopentamer interface [polypeptide binding]; other site 394503006600 active site 394503006601 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 394503006602 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 394503006603 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 394503006604 dimerization interface [polypeptide binding]; other site 394503006605 active site 394503006606 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 394503006607 Lumazine binding domain; Region: Lum_binding; pfam00677 394503006608 Lumazine binding domain; Region: Lum_binding; pfam00677 394503006609 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 394503006610 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 394503006611 catalytic motif [active] 394503006612 Zn binding site [ion binding]; other site 394503006613 RibD C-terminal domain; Region: RibD_C; cl17279 394503006614 DNA polymerase IV; Reviewed; Region: PRK03103 394503006615 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 394503006616 active site 394503006617 DNA binding site [nucleotide binding] 394503006618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503006619 Transposase; Region: HTH_Tnp_1; pfam01527 394503006620 putative transposase OrfB; Reviewed; Region: PHA02517 394503006621 HTH-like domain; Region: HTH_21; pfam13276 394503006622 Integrase core domain; Region: rve; pfam00665 394503006623 Integrase core domain; Region: rve_3; pfam13683 394503006624 Right handed beta helix region; Region: Beta_helix; pfam13229 394503006625 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 394503006626 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 394503006627 active site 394503006628 Helix-turn-helix domain; Region: HTH_18; pfam12833 394503006629 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 394503006630 active site 394503006631 catalytic triad [active] 394503006632 oxyanion hole [active] 394503006633 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503006634 YceG-like family; Region: YceG; pfam02618 394503006635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 394503006636 Protein of unknown function (DUF342); Region: DUF342; pfam03961 394503006637 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 394503006638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503006639 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 394503006640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503006641 DNA binding residues [nucleotide binding] 394503006642 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 394503006643 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 394503006644 CheC-like family; Region: CheC; pfam04509 394503006645 CheC-like family; Region: CheC; pfam04509 394503006646 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 394503006647 putative CheA interaction surface; other site 394503006648 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 394503006649 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 394503006650 putative binding surface; other site 394503006651 active site 394503006652 P2 response regulator binding domain; Region: P2; pfam07194 394503006653 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 394503006654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006655 ATP binding site [chemical binding]; other site 394503006656 Mg2+ binding site [ion binding]; other site 394503006657 G-X-G motif; other site 394503006658 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 394503006659 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 394503006660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006661 active site 394503006662 phosphorylation site [posttranslational modification] 394503006663 intermolecular recognition site; other site 394503006664 dimerization interface [polypeptide binding]; other site 394503006665 CheB methylesterase; Region: CheB_methylest; pfam01339 394503006666 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 394503006667 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 394503006668 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 394503006669 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 394503006670 FHIPEP family; Region: FHIPEP; pfam00771 394503006671 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 394503006672 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 394503006673 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 394503006674 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 394503006675 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 394503006676 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 394503006677 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 394503006678 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 394503006679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006680 active site 394503006681 phosphorylation site [posttranslational modification] 394503006682 intermolecular recognition site; other site 394503006683 dimerization interface [polypeptide binding]; other site 394503006684 flagellar motor switch protein; Validated; Region: PRK08119 394503006685 CheC-like family; Region: CheC; pfam04509 394503006686 CheC-like family; Region: CheC; pfam04509 394503006687 flagellar motor switch protein FliN; Region: fliN; TIGR02480 394503006688 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 394503006689 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 394503006690 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 394503006691 Flagellar protein (FlbD); Region: FlbD; pfam06289 394503006692 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 394503006693 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 394503006694 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 394503006695 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 394503006696 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 394503006697 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 394503006698 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 394503006699 Uncharacterized conserved protein [Function unknown]; Region: COG3334 394503006700 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 394503006701 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 394503006702 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 394503006703 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 394503006704 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 394503006705 Walker A motif/ATP binding site; other site 394503006706 Walker B motif; other site 394503006707 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 394503006708 Flagellar assembly protein FliH; Region: FliH; pfam02108 394503006709 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 394503006710 FliG C-terminal domain; Region: FliG_C; pfam01706 394503006711 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 394503006712 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 394503006713 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 394503006714 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 394503006715 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 394503006716 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 394503006717 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 394503006718 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 394503006719 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 394503006720 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 394503006721 Glucose inhibited division protein A; Region: GIDA; pfam01134 394503006722 DNA topoisomerase I; Validated; Region: PRK05582 394503006723 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 394503006724 active site 394503006725 interdomain interaction site; other site 394503006726 putative metal-binding site [ion binding]; other site 394503006727 nucleotide binding site [chemical binding]; other site 394503006728 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 394503006729 domain I; other site 394503006730 DNA binding groove [nucleotide binding] 394503006731 phosphate binding site [ion binding]; other site 394503006732 domain II; other site 394503006733 domain III; other site 394503006734 nucleotide binding site [chemical binding]; other site 394503006735 catalytic site [active] 394503006736 domain IV; other site 394503006737 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 394503006738 DNA protecting protein DprA; Region: dprA; TIGR00732 394503006739 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 394503006740 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 394503006741 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 394503006742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503006743 Walker A motif; other site 394503006744 ATP binding site [chemical binding]; other site 394503006745 Walker B motif; other site 394503006746 arginine finger; other site 394503006747 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 394503006748 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 394503006749 ATP cone domain; Region: ATP-cone; pfam03477 394503006750 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 394503006751 sporulation sigma factor SigG; Reviewed; Region: PRK08215 394503006752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503006753 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 394503006754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503006755 DNA binding residues [nucleotide binding] 394503006756 sporulation sigma factor SigE; Reviewed; Region: PRK08301 394503006757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503006758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503006759 DNA binding residues [nucleotide binding] 394503006760 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 394503006761 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 394503006762 cell division protein FtsZ; Validated; Region: PRK09330 394503006763 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 394503006764 nucleotide binding site [chemical binding]; other site 394503006765 SulA interaction site; other site 394503006766 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 394503006767 Cell division protein FtsA; Region: FtsA; smart00842 394503006768 Cell division protein FtsA; Region: FtsA; pfam14450 394503006769 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 394503006770 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 394503006771 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 394503006772 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503006773 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 394503006774 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 394503006775 catalytic triad [active] 394503006776 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 394503006777 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 394503006778 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 394503006779 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 394503006780 N-acetyl-D-glucosamine binding site [chemical binding]; other site 394503006781 catalytic residue [active] 394503006782 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 394503006783 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 394503006784 CoA-binding site [chemical binding]; other site 394503006785 DNA polymerase I; Provisional; Region: PRK05755 394503006786 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 394503006787 active site 394503006788 metal binding site 1 [ion binding]; metal-binding site 394503006789 putative 5' ssDNA interaction site; other site 394503006790 metal binding site 3; metal-binding site 394503006791 metal binding site 2 [ion binding]; metal-binding site 394503006792 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 394503006793 putative DNA binding site [nucleotide binding]; other site 394503006794 putative metal binding site [ion binding]; other site 394503006795 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 394503006796 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 394503006797 active site 394503006798 DNA binding site [nucleotide binding] 394503006799 catalytic site [active] 394503006800 Putative zinc-finger; Region: zf-HC2; pfam13490 394503006801 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 394503006802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503006803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503006804 DNA binding residues [nucleotide binding] 394503006805 Coat F domain; Region: Coat_F; pfam07875 394503006806 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 394503006807 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 394503006808 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 394503006809 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 394503006810 active site 394503006811 HIGH motif; other site 394503006812 dimer interface [polypeptide binding]; other site 394503006813 KMSKS motif; other site 394503006814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503006815 RNA binding surface [nucleotide binding]; other site 394503006816 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 394503006817 TrkA-N domain; Region: TrkA_N; pfam02254 394503006818 TrkA-C domain; Region: TrkA_C; pfam02080 394503006819 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 394503006820 TrkA-N domain; Region: TrkA_N; pfam02254 394503006821 Predicted membrane protein [Function unknown]; Region: COG2323 394503006822 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 394503006823 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 394503006824 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 394503006825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 394503006826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503006827 putative substrate translocation pore; other site 394503006828 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 394503006829 classical (c) SDRs; Region: SDR_c; cd05233 394503006830 NAD(P) binding site [chemical binding]; other site 394503006831 active site 394503006832 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 394503006833 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 394503006834 conserved cys residue [active] 394503006835 Flagellin N-methylase; Region: FliB; cl00497 394503006836 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 394503006837 putative active site [active] 394503006838 putative metal binding residues [ion binding]; other site 394503006839 signature motif; other site 394503006840 putative dimer interface [polypeptide binding]; other site 394503006841 putative phosphate binding site [ion binding]; other site 394503006842 Yqey-like protein; Region: YqeY; pfam09424 394503006843 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 394503006844 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 394503006845 nucleotide binding site/active site [active] 394503006846 HIT family signature motif; other site 394503006847 catalytic residue [active] 394503006848 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 394503006849 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 394503006850 motif 1; other site 394503006851 active site 394503006852 motif 2; other site 394503006853 motif 3; other site 394503006854 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 394503006855 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 394503006856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503006857 active site 394503006858 motif I; other site 394503006859 motif II; other site 394503006860 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 394503006861 heterotetramer interface [polypeptide binding]; other site 394503006862 active site pocket [active] 394503006863 cleavage site 394503006864 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 394503006865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 394503006866 dimerization interface [polypeptide binding]; other site 394503006867 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503006868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503006869 dimer interface [polypeptide binding]; other site 394503006870 putative CheW interface [polypeptide binding]; other site 394503006871 PBP superfamily domain; Region: PBP_like_2; cl17296 394503006872 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 394503006873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503006874 dimer interface [polypeptide binding]; other site 394503006875 conserved gate region; other site 394503006876 putative PBP binding loops; other site 394503006877 ABC-ATPase subunit interface; other site 394503006878 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 394503006879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503006880 dimer interface [polypeptide binding]; other site 394503006881 conserved gate region; other site 394503006882 putative PBP binding loops; other site 394503006883 ABC-ATPase subunit interface; other site 394503006884 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 394503006885 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 394503006886 Walker A/P-loop; other site 394503006887 ATP binding site [chemical binding]; other site 394503006888 Q-loop/lid; other site 394503006889 ABC transporter signature motif; other site 394503006890 Walker B; other site 394503006891 D-loop; other site 394503006892 H-loop/switch region; other site 394503006893 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 394503006894 PhoU domain; Region: PhoU; pfam01895 394503006895 PhoU domain; Region: PhoU; pfam01895 394503006896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503006897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006898 active site 394503006899 phosphorylation site [posttranslational modification] 394503006900 intermolecular recognition site; other site 394503006901 dimerization interface [polypeptide binding]; other site 394503006902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503006903 DNA binding site [nucleotide binding] 394503006904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503006905 dimerization interface [polypeptide binding]; other site 394503006906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503006907 dimer interface [polypeptide binding]; other site 394503006908 phosphorylation site [posttranslational modification] 394503006909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006910 ATP binding site [chemical binding]; other site 394503006911 Mg2+ binding site [ion binding]; other site 394503006912 G-X-G motif; other site 394503006913 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503006914 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 394503006915 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 394503006916 catalytic domain interface [polypeptide binding]; other site 394503006917 homodimer interface [polypeptide binding]; other site 394503006918 putative active site [active] 394503006919 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503006920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503006921 dimer interface [polypeptide binding]; other site 394503006922 conserved gate region; other site 394503006923 putative PBP binding loops; other site 394503006924 ABC-ATPase subunit interface; other site 394503006925 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503006926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503006927 dimer interface [polypeptide binding]; other site 394503006928 conserved gate region; other site 394503006929 putative PBP binding loops; other site 394503006930 ABC-ATPase subunit interface; other site 394503006931 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503006932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503006933 Response regulator receiver domain; Region: Response_reg; pfam00072 394503006934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503006935 active site 394503006936 phosphorylation site [posttranslational modification] 394503006937 intermolecular recognition site; other site 394503006938 dimerization interface [polypeptide binding]; other site 394503006939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503006940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503006941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503006942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503006943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503006944 dimerization interface [polypeptide binding]; other site 394503006945 Histidine kinase; Region: His_kinase; pfam06580 394503006946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503006947 ATP binding site [chemical binding]; other site 394503006948 Mg2+ binding site [ion binding]; other site 394503006949 G-X-G motif; other site 394503006950 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503006951 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503006952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503006953 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 394503006954 Walker A motif; other site 394503006955 ATP binding site [chemical binding]; other site 394503006956 Walker B motif; other site 394503006957 arginine finger; other site 394503006958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503006959 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 394503006960 Walker A motif; other site 394503006961 ATP binding site [chemical binding]; other site 394503006962 Walker B motif; other site 394503006963 arginine finger; other site 394503006964 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 394503006965 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 394503006966 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 394503006967 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 394503006968 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 394503006969 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 394503006970 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 394503006971 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 394503006972 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503006973 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503006974 catalytic residues [active] 394503006975 catalytic nucleophile [active] 394503006976 Recombinase; Region: Recombinase; pfam07508 394503006977 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503006978 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 394503006979 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 394503006980 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 394503006981 Accessory gene regulator B; Region: AgrB; pfam04647 394503006982 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503006983 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503006984 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503006985 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 394503006986 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 394503006987 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 394503006988 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 394503006989 GTP-binding protein Der; Reviewed; Region: PRK00093 394503006990 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 394503006991 G1 box; other site 394503006992 GTP/Mg2+ binding site [chemical binding]; other site 394503006993 Switch I region; other site 394503006994 G2 box; other site 394503006995 Switch II region; other site 394503006996 G3 box; other site 394503006997 G4 box; other site 394503006998 G5 box; other site 394503006999 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 394503007000 G1 box; other site 394503007001 GTP/Mg2+ binding site [chemical binding]; other site 394503007002 Switch I region; other site 394503007003 G2 box; other site 394503007004 G3 box; other site 394503007005 Switch II region; other site 394503007006 G4 box; other site 394503007007 G5 box; other site 394503007008 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 394503007009 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 394503007010 Protein of unknown function (DUF512); Region: DUF512; pfam04459 394503007011 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503007012 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 394503007013 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 394503007014 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 394503007015 propionate/acetate kinase; Provisional; Region: PRK12379 394503007016 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 394503007017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503007019 S-adenosylmethionine binding site [chemical binding]; other site 394503007020 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 394503007021 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 394503007022 active site 394503007023 HIGH motif; other site 394503007024 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 394503007025 active site 394503007026 KMSKS motif; other site 394503007027 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 394503007028 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 394503007029 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503007030 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503007031 catalytic residues [active] 394503007032 catalytic nucleophile [active] 394503007033 Recombinase; Region: Recombinase; pfam07508 394503007034 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503007035 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 394503007036 PKC phosphorylation site [posttranslational modification]; other site 394503007037 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 394503007038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007039 ATP binding site [chemical binding]; other site 394503007040 Mg2+ binding site [ion binding]; other site 394503007041 G-X-G motif; other site 394503007042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503007043 Response regulator receiver domain; Region: Response_reg; pfam00072 394503007044 active site 394503007045 phosphorylation site [posttranslational modification] 394503007046 intermolecular recognition site; other site 394503007047 dimerization interface [polypeptide binding]; other site 394503007048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503007049 non-specific DNA binding site [nucleotide binding]; other site 394503007050 salt bridge; other site 394503007051 sequence-specific DNA binding site [nucleotide binding]; other site 394503007052 Inclusion body protein; Region: PixA; pfam12306 394503007053 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503007054 Winged helix-turn helix; Region: HTH_29; pfam13551 394503007055 Homeodomain-like domain; Region: HTH_32; pfam13565 394503007056 Integrase core domain; Region: rve; pfam00665 394503007057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503007058 Integrase core domain; Region: rve_3; pfam13683 394503007059 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503007060 RHS Repeat; Region: RHS_repeat; pfam05593 394503007061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503007062 HTH-like domain; Region: HTH_21; pfam13276 394503007063 Integrase core domain; Region: rve; pfam00665 394503007064 Integrase core domain; Region: rve_2; pfam13333 394503007065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503007066 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503007067 Transposase; Region: HTH_Tnp_1; cl17663 394503007068 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 394503007069 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 394503007070 substrate binding pocket [chemical binding]; other site 394503007071 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 394503007072 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 394503007073 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 394503007074 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 394503007075 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503007076 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503007077 Walker A/P-loop; other site 394503007078 ATP binding site [chemical binding]; other site 394503007079 Q-loop/lid; other site 394503007080 ABC transporter signature motif; other site 394503007081 Walker B; other site 394503007082 D-loop; other site 394503007083 H-loop/switch region; other site 394503007084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503007085 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503007086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503007087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503007088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 394503007089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 394503007090 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 394503007091 active site 394503007092 catalytic triad [active] 394503007093 oxyanion hole [active] 394503007094 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 394503007095 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 394503007096 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 394503007097 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 394503007098 active site 394503007099 putative substrate binding pocket [chemical binding]; other site 394503007100 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 394503007101 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 394503007102 homotetramer interface [polypeptide binding]; other site 394503007103 ligand binding site [chemical binding]; other site 394503007104 catalytic site [active] 394503007105 NAD binding site [chemical binding]; other site 394503007106 Carbohydrate binding domain; Region: CBM_25; smart01066 394503007107 Methyltransferase domain; Region: Methyltransf_31; pfam13847 394503007108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503007109 S-adenosylmethionine binding site [chemical binding]; other site 394503007110 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503007111 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 394503007112 RNA binding surface [nucleotide binding]; other site 394503007113 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 394503007114 active site 394503007115 uracil binding [chemical binding]; other site 394503007116 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 394503007117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503007118 S-adenosylmethionine binding site [chemical binding]; other site 394503007119 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 394503007120 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503007121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503007122 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503007123 DNA binding residues [nucleotide binding] 394503007124 Transcriptional regulators [Transcription]; Region: FadR; COG2186 394503007125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503007126 DNA-binding site [nucleotide binding]; DNA binding site 394503007127 FCD domain; Region: FCD; pfam07729 394503007128 aconitate hydratase; Validated; Region: PRK07229 394503007129 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 394503007130 substrate binding site [chemical binding]; other site 394503007131 ligand binding site [chemical binding]; other site 394503007132 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 394503007133 substrate binding site [chemical binding]; other site 394503007134 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 394503007135 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 394503007136 active site 394503007137 catalytic residues [active] 394503007138 metal binding site [ion binding]; metal-binding site 394503007139 Transposase; Region: HTH_Tnp_1; pfam01527 394503007140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503007141 putative transposase OrfB; Reviewed; Region: PHA02517 394503007142 HTH-like domain; Region: HTH_21; pfam13276 394503007143 Integrase core domain; Region: rve; pfam00665 394503007144 Integrase core domain; Region: rve_3; pfam13683 394503007145 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 394503007146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503007147 dimer interface [polypeptide binding]; other site 394503007148 putative CheW interface [polypeptide binding]; other site 394503007149 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 394503007150 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 394503007151 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 394503007152 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 394503007153 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 394503007154 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 394503007155 purine monophosphate binding site [chemical binding]; other site 394503007156 dimer interface [polypeptide binding]; other site 394503007157 putative catalytic residues [active] 394503007158 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 394503007159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 394503007160 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 394503007161 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 394503007162 active site 394503007163 substrate binding site [chemical binding]; other site 394503007164 cosubstrate binding site; other site 394503007165 catalytic site [active] 394503007166 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 394503007167 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 394503007168 dimerization interface [polypeptide binding]; other site 394503007169 putative ATP binding site [chemical binding]; other site 394503007170 amidophosphoribosyltransferase; Provisional; Region: PRK05793 394503007171 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 394503007172 active site 394503007173 tetramer interface [polypeptide binding]; other site 394503007174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503007175 active site 394503007176 AIR carboxylase; Region: AIRC; pfam00731 394503007177 Membrane transport protein; Region: Mem_trans; pfam03547 394503007178 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 394503007179 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 394503007180 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503007181 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503007182 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 394503007183 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503007184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503007185 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503007186 NlpC/P60 family; Region: NLPC_P60; cl17555 394503007187 L-idonate 5-dehydrogenase; Region: PLN02702 394503007188 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 394503007189 inhibitor binding site; inhibition site 394503007190 catalytic Zn binding site [ion binding]; other site 394503007191 structural Zn binding site [ion binding]; other site 394503007192 NADP binding site [chemical binding]; other site 394503007193 tetramer interface [polypeptide binding]; other site 394503007194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 394503007195 putative DNA binding site [nucleotide binding]; other site 394503007196 putative Zn2+ binding site [ion binding]; other site 394503007197 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 394503007198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 394503007199 nucleotide binding site [chemical binding]; other site 394503007200 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 394503007201 active site 394503007202 catalytic site [active] 394503007203 substrate binding site [chemical binding]; other site 394503007204 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 394503007205 Predicted transcriptional regulators [Transcription]; Region: COG1695 394503007206 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 394503007207 RNA polymerase sigma factor; Provisional; Region: PRK12514 394503007208 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 394503007209 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 394503007210 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 394503007211 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 394503007212 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 394503007213 DNA binding residues [nucleotide binding] 394503007214 putative transposase OrfB; Reviewed; Region: PHA02517 394503007215 HTH-like domain; Region: HTH_21; pfam13276 394503007216 Integrase core domain; Region: rve; pfam00665 394503007217 Integrase core domain; Region: rve_3; pfam13683 394503007218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503007219 Transposase; Region: HTH_Tnp_1; pfam01527 394503007220 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 394503007221 GMP synthase; Reviewed; Region: guaA; PRK00074 394503007222 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 394503007223 AMP/PPi binding site [chemical binding]; other site 394503007224 candidate oxyanion hole; other site 394503007225 catalytic triad [active] 394503007226 potential glutamine specificity residues [chemical binding]; other site 394503007227 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 394503007228 ATP Binding subdomain [chemical binding]; other site 394503007229 Ligand Binding sites [chemical binding]; other site 394503007230 Dimerization subdomain; other site 394503007231 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 394503007232 Protein of unknown function DUF111; Region: DUF111; pfam01969 394503007233 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 394503007234 AIR carboxylase; Region: AIRC; smart01001 394503007235 peptide chain release factor 2; Validated; Region: prfB; PRK00578 394503007236 PCRF domain; Region: PCRF; pfam03462 394503007237 RF-1 domain; Region: RF-1; pfam00472 394503007238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503007239 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 394503007240 active site 394503007241 motif I; other site 394503007242 motif II; other site 394503007243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503007244 hypothetical protein; Validated; Region: PRK07682 394503007245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503007246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503007247 homodimer interface [polypeptide binding]; other site 394503007248 catalytic residue [active] 394503007249 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 394503007250 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 394503007251 AsnC family; Region: AsnC_trans_reg; pfam01037 394503007252 DivIVA protein; Region: DivIVA; pfam05103 394503007253 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 394503007254 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 394503007255 catalytic residues [active] 394503007256 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 394503007257 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 394503007258 putative homodimer interface [polypeptide binding]; other site 394503007259 putative active site pocket [active] 394503007260 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 394503007261 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 394503007262 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 394503007263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 394503007264 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 394503007265 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 394503007266 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503007267 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503007268 active site 394503007269 metal binding site [ion binding]; metal-binding site 394503007270 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 394503007271 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 394503007272 intersubunit interface [polypeptide binding]; other site 394503007273 active site 394503007274 zinc binding site [ion binding]; other site 394503007275 Na+ binding site [ion binding]; other site 394503007276 6-phosphofructokinase; Provisional; Region: PRK14072 394503007277 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 394503007278 active site 394503007279 ADP/pyrophosphate binding site [chemical binding]; other site 394503007280 dimerization interface [polypeptide binding]; other site 394503007281 allosteric effector site; other site 394503007282 fructose-1,6-bisphosphate binding site; other site 394503007283 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 394503007284 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 394503007285 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 394503007286 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 394503007287 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503007288 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 394503007289 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 394503007290 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 394503007291 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 394503007292 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503007293 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 394503007294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 394503007295 catalytic loop [active] 394503007296 iron binding site [ion binding]; other site 394503007297 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 394503007298 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 394503007299 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 394503007300 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 394503007301 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 394503007302 dimer interface [polypeptide binding]; other site 394503007303 [2Fe-2S] cluster binding site [ion binding]; other site 394503007304 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 394503007305 SLBB domain; Region: SLBB; pfam10531 394503007306 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 394503007307 4Fe-4S binding domain; Region: Fer4; pfam00037 394503007308 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 394503007309 4Fe-4S binding domain; Region: Fer4; pfam00037 394503007310 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 394503007311 dimer interface [polypeptide binding]; other site 394503007312 [2Fe-2S] cluster binding site [ion binding]; other site 394503007313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007314 ATP binding site [chemical binding]; other site 394503007315 Mg2+ binding site [ion binding]; other site 394503007316 G-X-G motif; other site 394503007317 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 394503007318 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 394503007319 putative dimer interface [polypeptide binding]; other site 394503007320 [2Fe-2S] cluster binding site [ion binding]; other site 394503007321 Cache domain; Region: Cache_1; pfam02743 394503007322 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 394503007323 HAMP domain; Region: HAMP; pfam00672 394503007324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503007325 dimer interface [polypeptide binding]; other site 394503007326 putative CheW interface [polypeptide binding]; other site 394503007327 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 394503007328 hypothetical protein; Provisional; Region: PRK05473 394503007329 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 394503007330 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 394503007331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503007332 FeS/SAM binding site; other site 394503007333 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 394503007334 Amb_all domain; Region: Amb_all; smart00656 394503007335 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 394503007336 regulatory protein interface [polypeptide binding]; other site 394503007337 regulatory phosphorylation site [posttranslational modification]; other site 394503007338 Uncharacterized conserved protein [Function unknown]; Region: COG1683 394503007339 ribonuclease R; Region: RNase_R; TIGR02063 394503007340 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 394503007341 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 394503007342 RNB domain; Region: RNB; pfam00773 394503007343 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 394503007344 RNA binding site [nucleotide binding]; other site 394503007345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503007346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503007347 dimerization interface [polypeptide binding]; other site 394503007348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503007349 dimer interface [polypeptide binding]; other site 394503007350 phosphorylation site [posttranslational modification] 394503007351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007352 ATP binding site [chemical binding]; other site 394503007353 Mg2+ binding site [ion binding]; other site 394503007354 G-X-G motif; other site 394503007355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503007356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503007357 active site 394503007358 phosphorylation site [posttranslational modification] 394503007359 intermolecular recognition site; other site 394503007360 dimerization interface [polypeptide binding]; other site 394503007361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503007362 DNA binding site [nucleotide binding] 394503007363 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 394503007364 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 394503007365 NodB motif; other site 394503007366 active site 394503007367 catalytic site [active] 394503007368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 394503007369 Preprotein translocase SecG subunit; Region: SecG; pfam03840 394503007370 enolase; Provisional; Region: eno; PRK00077 394503007371 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 394503007372 dimer interface [polypeptide binding]; other site 394503007373 metal binding site [ion binding]; metal-binding site 394503007374 substrate binding pocket [chemical binding]; other site 394503007375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503007376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503007377 sequence-specific DNA binding site [nucleotide binding]; other site 394503007378 salt bridge; other site 394503007379 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 394503007380 phosphoglyceromutase; Provisional; Region: PRK05434 394503007381 bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962 394503007382 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 394503007383 substrate binding site [chemical binding]; other site 394503007384 hinge regions; other site 394503007385 ADP binding site [chemical binding]; other site 394503007386 catalytic site [active] 394503007387 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 394503007388 substrate binding site [chemical binding]; other site 394503007389 dimer interface [polypeptide binding]; other site 394503007390 catalytic triad [active] 394503007391 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 394503007392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 394503007393 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 394503007394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 394503007395 HlyD family secretion protein; Region: HlyD_3; pfam13437 394503007396 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 394503007397 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 394503007398 putative active site [active] 394503007399 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503007400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503007401 Walker A/P-loop; other site 394503007402 ATP binding site [chemical binding]; other site 394503007403 Q-loop/lid; other site 394503007404 ABC transporter signature motif; other site 394503007405 Walker B; other site 394503007406 D-loop; other site 394503007407 H-loop/switch region; other site 394503007408 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 394503007409 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 394503007410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503007411 active site 394503007412 phosphorylation site [posttranslational modification] 394503007413 intermolecular recognition site; other site 394503007414 dimerization interface [polypeptide binding]; other site 394503007415 LytTr DNA-binding domain; Region: LytTR; pfam04397 394503007416 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 394503007417 DEAD/DEAH box helicase; Region: DEAD; pfam00270 394503007418 ATP binding site [chemical binding]; other site 394503007419 putative Mg++ binding site [ion binding]; other site 394503007420 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 394503007421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 394503007422 nucleotide binding region [chemical binding]; other site 394503007423 ATP-binding site [chemical binding]; other site 394503007424 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 394503007425 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 394503007426 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 394503007427 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 394503007428 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 394503007429 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 394503007430 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 394503007431 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 394503007432 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 394503007433 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 394503007434 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 394503007435 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 394503007436 peptidase T-like protein; Region: PepT-like; TIGR01883 394503007437 metal binding site [ion binding]; metal-binding site 394503007438 putative dimer interface [polypeptide binding]; other site 394503007439 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 394503007440 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 394503007441 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 394503007442 SpoVA protein; Region: SpoVA; pfam03862 394503007443 stage V sporulation protein AD; Validated; Region: PRK08304 394503007444 stage V sporulation protein AD; Provisional; Region: PRK12404 394503007445 SpoVA protein; Region: SpoVA; cl04298 394503007446 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 394503007447 sporulation sigma factor SigF; Validated; Region: PRK05572 394503007448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503007449 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 394503007450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503007451 DNA binding residues [nucleotide binding] 394503007452 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 394503007453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007454 ATP binding site [chemical binding]; other site 394503007455 Mg2+ binding site [ion binding]; other site 394503007456 G-X-G motif; other site 394503007457 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 394503007458 anti sigma factor interaction site; other site 394503007459 regulatory phosphorylation site [posttranslational modification]; other site 394503007460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 394503007461 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 394503007462 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 394503007463 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 394503007464 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 394503007465 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 394503007466 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 394503007467 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 394503007468 phosphate binding site [ion binding]; other site 394503007469 putative substrate binding pocket [chemical binding]; other site 394503007470 dimer interface [polypeptide binding]; other site 394503007471 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 394503007472 shikimate kinase; Provisional; Region: PRK13947 394503007473 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 394503007474 FAD binding domain; Region: FAD_binding_4; pfam01565 394503007475 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 394503007476 putative hydrolase; Validated; Region: PRK09248 394503007477 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 394503007478 active site 394503007479 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 394503007480 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 394503007481 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 394503007482 Hpr binding site; other site 394503007483 active site 394503007484 homohexamer subunit interaction site [polypeptide binding]; other site 394503007485 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 394503007486 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 394503007487 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 394503007488 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 394503007489 active site 394503007490 NTP binding site [chemical binding]; other site 394503007491 metal binding triad [ion binding]; metal-binding site 394503007492 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 394503007493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503007494 Zn2+ binding site [ion binding]; other site 394503007495 Mg2+ binding site [ion binding]; other site 394503007496 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 394503007497 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 394503007498 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 394503007499 4Fe-4S binding domain; Region: Fer4_6; pfam12837 394503007500 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 394503007501 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 394503007502 Putative Fe-S cluster; Region: FeS; cl17515 394503007503 PAS domain; Region: PAS; smart00091 394503007504 PAS domain S-box; Region: sensory_box; TIGR00229 394503007505 putative active site [active] 394503007506 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 394503007507 dimer interface [polypeptide binding]; other site 394503007508 [2Fe-2S] cluster binding site [ion binding]; other site 394503007509 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 394503007510 catalytic loop [active] 394503007511 iron binding site [ion binding]; other site 394503007512 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 394503007513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503007514 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 394503007515 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 394503007516 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 394503007517 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 394503007518 dimer interface [polypeptide binding]; other site 394503007519 [2Fe-2S] cluster binding site [ion binding]; other site 394503007520 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 394503007521 SLBB domain; Region: SLBB; pfam10531 394503007522 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 394503007523 4Fe-4S binding domain; Region: Fer4_6; pfam12837 394503007524 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 394503007525 4Fe-4S binding domain; Region: Fer4; pfam00037 394503007526 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 394503007527 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 394503007528 putative dimer interface [polypeptide binding]; other site 394503007529 [2Fe-2S] cluster binding site [ion binding]; other site 394503007530 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 394503007531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503007532 active site 394503007533 catalytic tetrad [active] 394503007534 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503007535 Protein of unknown function DUF45; Region: DUF45; pfam01863 394503007536 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 394503007537 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 394503007538 ArsC family; Region: ArsC; pfam03960 394503007539 catalytic residue [active] 394503007540 CheB methylesterase; Region: CheB_methylest; pfam01339 394503007541 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 394503007542 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 394503007543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503007544 dimerization interface [polypeptide binding]; other site 394503007545 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503007546 dimer interface [polypeptide binding]; other site 394503007547 putative CheW interface [polypeptide binding]; other site 394503007548 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 394503007549 putative CheA interaction surface; other site 394503007550 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 394503007551 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 394503007552 putative binding surface; other site 394503007553 active site 394503007554 P2 response regulator binding domain; Region: P2; pfam07194 394503007555 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 394503007556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007557 ATP binding site [chemical binding]; other site 394503007558 Mg2+ binding site [ion binding]; other site 394503007559 G-X-G motif; other site 394503007560 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 394503007561 Response regulator receiver domain; Region: Response_reg; pfam00072 394503007562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503007563 active site 394503007564 phosphorylation site [posttranslational modification] 394503007565 intermolecular recognition site; other site 394503007566 dimerization interface [polypeptide binding]; other site 394503007567 PilZ domain; Region: PilZ; pfam07238 394503007568 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 394503007569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 394503007570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 394503007571 metal binding site [ion binding]; metal-binding site 394503007572 active site 394503007573 I-site; other site 394503007574 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503007575 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 394503007576 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 394503007577 Ca binding site [ion binding]; other site 394503007578 carbohydrate binding site [chemical binding]; other site 394503007579 S-layer homology domain; Region: SLH; pfam00395 394503007580 S-layer homology domain; Region: SLH; pfam00395 394503007581 S-layer homology domain; Region: SLH; pfam00395 394503007582 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503007583 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 394503007584 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 394503007585 Ca binding site [ion binding]; other site 394503007586 carbohydrate binding site [chemical binding]; other site 394503007587 S-layer homology domain; Region: SLH; pfam00395 394503007588 S-layer homology domain; Region: SLH; pfam00395 394503007589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503007590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503007591 dimer interface [polypeptide binding]; other site 394503007592 phosphorylation site [posttranslational modification] 394503007593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503007594 ATP binding site [chemical binding]; other site 394503007595 Mg2+ binding site [ion binding]; other site 394503007596 G-X-G motif; other site 394503007597 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 394503007598 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 394503007599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503007600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503007601 Walker A/P-loop; other site 394503007602 ATP binding site [chemical binding]; other site 394503007603 Q-loop/lid; other site 394503007604 ABC transporter signature motif; other site 394503007605 Walker B; other site 394503007606 D-loop; other site 394503007607 H-loop/switch region; other site 394503007608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503007609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503007610 active site 394503007611 phosphorylation site [posttranslational modification] 394503007612 intermolecular recognition site; other site 394503007613 dimerization interface [polypeptide binding]; other site 394503007614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503007615 DNA binding site [nucleotide binding] 394503007616 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 394503007617 glycosyltransferase, MGT family; Region: MGT; TIGR01426 394503007618 active site 394503007619 TDP-binding site; other site 394503007620 acceptor substrate-binding pocket; other site 394503007621 homodimer interface [polypeptide binding]; other site 394503007622 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007623 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 394503007624 glycosyltransferase, MGT family; Region: MGT; TIGR01426 394503007625 active site 394503007626 TDP-binding site; other site 394503007627 acceptor substrate-binding pocket; other site 394503007628 homodimer interface [polypeptide binding]; other site 394503007629 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 394503007630 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503007631 Condensation domain; Region: Condensation; pfam00668 394503007632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007633 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007634 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 394503007635 Acid Phosphatase; Region: Acid_PPase; cl17256 394503007636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007637 Condensation domain; Region: Condensation; pfam00668 394503007638 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007639 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007640 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007641 acyl-activating enzyme (AAE) consensus motif; other site 394503007642 AMP binding site [chemical binding]; other site 394503007643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007644 Condensation domain; Region: Condensation; pfam00668 394503007645 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 394503007646 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007648 active site 394503007649 Acyl transferase domain; Region: Acyl_transf_1; cl08282 394503007650 Acyl transferase domain; Region: Acyl_transf_1; cl08282 394503007651 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007652 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 394503007653 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 394503007654 acyl-activating enzyme (AAE) consensus motif; other site 394503007655 putative AMP binding site [chemical binding]; other site 394503007656 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007657 Condensation domain; Region: Condensation; pfam00668 394503007658 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007659 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007660 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 394503007661 acyl-activating enzyme (AAE) consensus motif; other site 394503007662 AMP binding site [chemical binding]; other site 394503007663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007664 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007665 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007666 active site 394503007667 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007668 putative NADP binding site [chemical binding]; other site 394503007669 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007670 active site 394503007671 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503007672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007673 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 394503007674 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 394503007675 Walker A/P-loop; other site 394503007676 ATP binding site [chemical binding]; other site 394503007677 Q-loop/lid; other site 394503007678 ABC transporter signature motif; other site 394503007679 Walker B; other site 394503007680 D-loop; other site 394503007681 H-loop/switch region; other site 394503007682 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503007683 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503007684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 394503007685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503007686 TPR motif; other site 394503007687 binding surface 394503007688 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 394503007689 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 394503007690 MARCKS family; Region: MARCKS; pfam02063 394503007691 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 394503007692 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 394503007693 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 394503007694 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 394503007695 TIR domain; Region: TIR_2; pfam13676 394503007696 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 394503007697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503007698 Walker A/P-loop; other site 394503007699 ATP binding site [chemical binding]; other site 394503007700 Q-loop/lid; other site 394503007701 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 394503007702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503007703 ABC transporter signature motif; other site 394503007704 Walker B; other site 394503007705 D-loop; other site 394503007706 H-loop/switch region; other site 394503007707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503007708 Walker A/P-loop; other site 394503007709 ATP binding site [chemical binding]; other site 394503007710 Q-loop/lid; other site 394503007711 ABC transporter signature motif; other site 394503007712 Walker B; other site 394503007713 D-loop; other site 394503007714 H-loop/switch region; other site 394503007715 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 394503007716 Beta-lactamase; Region: Beta-lactamase; pfam00144 394503007717 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 394503007718 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 394503007719 active site 394503007720 FMN binding site [chemical binding]; other site 394503007721 putative catalytic residues [active] 394503007722 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 394503007723 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 394503007724 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 394503007725 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 394503007726 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 394503007727 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 394503007728 Walker A/P-loop; other site 394503007729 ATP binding site [chemical binding]; other site 394503007730 Q-loop/lid; other site 394503007731 ABC transporter signature motif; other site 394503007732 Walker B; other site 394503007733 D-loop; other site 394503007734 H-loop/switch region; other site 394503007735 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503007736 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503007737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503007738 FeS/SAM binding site; other site 394503007739 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 394503007740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503007741 FeS/SAM binding site; other site 394503007742 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 394503007743 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 394503007744 nudix motif; other site 394503007745 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 394503007746 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 394503007747 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 394503007748 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 394503007749 catalytic domain interface [polypeptide binding]; other site 394503007750 putative homodimer interface [polypeptide binding]; other site 394503007751 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 394503007752 FtsX-like permease family; Region: FtsX; pfam02687 394503007753 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 394503007754 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 394503007755 FtsX-like permease family; Region: FtsX; pfam02687 394503007756 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503007757 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503007758 Walker A/P-loop; other site 394503007759 ATP binding site [chemical binding]; other site 394503007760 Q-loop/lid; other site 394503007761 ABC transporter signature motif; other site 394503007762 Walker B; other site 394503007763 D-loop; other site 394503007764 H-loop/switch region; other site 394503007765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 394503007766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 394503007767 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 394503007768 Transposase; Region: HTH_Tnp_1; pfam01527 394503007769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503007770 putative transposase OrfB; Reviewed; Region: PHA02517 394503007771 HTH-like domain; Region: HTH_21; pfam13276 394503007772 Integrase core domain; Region: rve; pfam00665 394503007773 Integrase core domain; Region: rve_3; pfam13683 394503007774 S-layer homology domain; Region: SLH; pfam00395 394503007775 S-layer homology domain; Region: SLH; pfam00395 394503007776 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 394503007777 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 394503007778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503007779 sequence-specific DNA binding site [nucleotide binding]; other site 394503007780 salt bridge; other site 394503007781 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 394503007782 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 394503007783 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 394503007784 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 394503007785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503007786 FeS/SAM binding site; other site 394503007787 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 394503007788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 394503007789 HTH-like domain; Region: HTH_21; pfam13276 394503007790 Integrase core domain; Region: rve; pfam00665 394503007791 Integrase core domain; Region: rve_2; pfam13333 394503007792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503007793 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503007794 Transposase; Region: HTH_Tnp_1; cl17663 394503007795 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 394503007796 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 394503007797 putative active site; other site 394503007798 catalytic residue [active] 394503007799 3-dehydroquinate synthase; Provisional; Region: PRK02290 394503007800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007801 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007802 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007803 active site 394503007804 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007805 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007806 putative NADP binding site [chemical binding]; other site 394503007807 active site 394503007808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007809 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 394503007810 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007811 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007812 active site 394503007813 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503007814 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007815 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007816 putative NADP binding site [chemical binding]; other site 394503007817 active site 394503007818 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007819 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007820 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007821 active site 394503007822 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503007823 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007824 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007825 putative NADP binding site [chemical binding]; other site 394503007826 active site 394503007827 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007828 Condensation domain; Region: Condensation; pfam00668 394503007829 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007830 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007831 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007832 acyl-activating enzyme (AAE) consensus motif; other site 394503007833 AMP binding site [chemical binding]; other site 394503007834 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007835 Condensation domain; Region: Condensation; pfam00668 394503007836 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007837 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007838 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007839 acyl-activating enzyme (AAE) consensus motif; other site 394503007840 AMP binding site [chemical binding]; other site 394503007841 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007842 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 394503007843 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 394503007844 B12 binding site [chemical binding]; other site 394503007845 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 394503007846 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 394503007847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007848 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 394503007849 acyl-activating enzyme (AAE) consensus motif; other site 394503007850 AMP binding site [chemical binding]; other site 394503007851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007852 Condensation domain; Region: Condensation; pfam00668 394503007853 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007854 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007855 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007856 acyl-activating enzyme (AAE) consensus motif; other site 394503007857 AMP binding site [chemical binding]; other site 394503007858 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007859 Condensation domain; Region: Condensation; pfam00668 394503007860 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007861 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007862 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007863 acyl-activating enzyme (AAE) consensus motif; other site 394503007864 AMP binding site [chemical binding]; other site 394503007865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007866 Condensation domain; Region: Condensation; pfam00668 394503007867 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007868 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007869 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007870 acyl-activating enzyme (AAE) consensus motif; other site 394503007871 AMP binding site [chemical binding]; other site 394503007872 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007873 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 394503007874 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 394503007875 Ligand Binding Site [chemical binding]; other site 394503007876 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007877 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007878 active site 394503007879 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 394503007880 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007881 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007882 putative NADP binding site [chemical binding]; other site 394503007883 active site 394503007884 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007885 Condensation domain; Region: Condensation; pfam00668 394503007886 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007887 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007889 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007890 active site 394503007891 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007892 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007893 putative NADP binding site [chemical binding]; other site 394503007894 active site 394503007895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007896 Condensation domain; Region: Condensation; pfam00668 394503007897 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007898 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 394503007899 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007900 acyl-activating enzyme (AAE) consensus motif; other site 394503007901 AMP binding site [chemical binding]; other site 394503007902 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007903 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 394503007904 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 394503007905 active site 394503007906 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 394503007907 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 394503007908 putative NADP binding site [chemical binding]; other site 394503007909 active site 394503007910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007911 Condensation domain; Region: Condensation; pfam00668 394503007912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007913 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503007914 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503007915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007916 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 394503007917 acyl-activating enzyme (AAE) consensus motif; other site 394503007918 AMP binding site [chemical binding]; other site 394503007919 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007920 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 394503007921 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 394503007922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503007923 FeS/SAM binding site; other site 394503007924 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 394503007925 hypothetical protein; Provisional; Region: PRK08296 394503007926 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 394503007927 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 394503007928 Beta-lactamase; Region: Beta-lactamase; pfam00144 394503007929 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 394503007930 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 394503007931 Walker A/P-loop; other site 394503007932 ATP binding site [chemical binding]; other site 394503007933 Q-loop/lid; other site 394503007934 ABC transporter signature motif; other site 394503007935 Walker B; other site 394503007936 D-loop; other site 394503007937 H-loop/switch region; other site 394503007938 Condensation domain; Region: Condensation; pfam00668 394503007939 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 394503007940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 394503007941 acyl-activating enzyme (AAE) consensus motif; other site 394503007942 AMP binding site [chemical binding]; other site 394503007943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503007944 Condensation domain; Region: Condensation; pfam00668 394503007945 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 394503007946 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 394503007947 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 394503007948 putative active site [active] 394503007949 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 394503007950 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 394503007951 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503007952 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503007953 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503007954 S-layer homology domain; Region: SLH; pfam00395 394503007955 S-layer homology domain; Region: SLH; pfam00395 394503007956 Right handed beta helix region; Region: Beta_helix; pfam13229 394503007957 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 394503007958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503007959 putative substrate translocation pore; other site 394503007960 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503007961 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 394503007962 active site 394503007963 catalytic triad [active] 394503007964 oxyanion hole [active] 394503007965 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 394503007966 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 394503007967 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 394503007968 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 394503007969 active site 394503007970 dimer interface [polypeptide binding]; other site 394503007971 effector binding site; other site 394503007972 TSCPD domain; Region: TSCPD; pfam12637 394503007973 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 394503007974 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503007975 Interdomain contacts; other site 394503007976 Cytokine receptor motif; other site 394503007977 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 394503007978 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503007979 Interdomain contacts; other site 394503007980 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 394503007981 Interdomain contacts; other site 394503007982 Cytokine receptor motif; other site 394503007983 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 394503007984 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 394503007985 Cell division protein FtsA; Region: FtsA; cl17206 394503007986 Cell division protein FtsA; Region: FtsA; pfam14450 394503007987 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 394503007988 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 394503007989 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 394503007990 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 394503007991 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 394503007992 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 394503007993 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 394503007994 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503007995 Walker A motif; other site 394503007996 ATP binding site [chemical binding]; other site 394503007997 Walker B motif; other site 394503007998 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 394503007999 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 394503008000 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 394503008001 Walker A motif; other site 394503008002 ATP binding site [chemical binding]; other site 394503008003 Walker B motif; other site 394503008004 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 394503008005 active site 394503008006 Fe-S cluster binding site [ion binding]; other site 394503008007 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 394503008008 Fe-S cluster binding site [ion binding]; other site 394503008009 active site 394503008010 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 394503008011 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 394503008012 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 394503008013 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 394503008014 GDP-binding site [chemical binding]; other site 394503008015 ACT binding site; other site 394503008016 IMP binding site; other site 394503008017 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 394503008018 Fumarase C-terminus; Region: Fumerase_C; cl00795 394503008019 fumarate hydratase; Provisional; Region: PRK06246 394503008020 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 394503008021 Ligand Binding Site [chemical binding]; other site 394503008022 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 394503008023 IHF - DNA interface [nucleotide binding]; other site 394503008024 IHF dimer interface [polypeptide binding]; other site 394503008025 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 394503008026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503008027 active site 394503008028 phosphorylation site [posttranslational modification] 394503008029 intermolecular recognition site; other site 394503008030 dimerization interface [polypeptide binding]; other site 394503008031 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 394503008032 shikimate kinase; Reviewed; Region: aroK; PRK00131 394503008033 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 394503008034 ADP binding site [chemical binding]; other site 394503008035 magnesium binding site [ion binding]; other site 394503008036 putative shikimate binding site; other site 394503008037 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 394503008038 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 394503008039 Tetramer interface [polypeptide binding]; other site 394503008040 active site 394503008041 FMN-binding site [chemical binding]; other site 394503008042 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 394503008043 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 394503008044 active site 394503008045 hinge; other site 394503008046 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 394503008047 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 394503008048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 394503008049 glutamate dehydrogenase; Provisional; Region: PRK09414 394503008050 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 394503008051 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 394503008052 NAD(P) binding site [chemical binding]; other site 394503008053 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 394503008054 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 394503008055 active site 394503008056 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 394503008057 Methyltransferase domain; Region: Methyltransf_26; pfam13659 394503008058 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 394503008059 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 394503008060 agmatinase; Region: agmatinase; TIGR01230 394503008061 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 394503008062 putative active site [active] 394503008063 Mn binding site [ion binding]; other site 394503008064 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 394503008065 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 394503008066 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 394503008067 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 394503008068 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 394503008069 GatB domain; Region: GatB_Yqey; smart00845 394503008070 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503008071 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 394503008072 catalytic residues [active] 394503008073 catalytic nucleophile [active] 394503008074 Presynaptic Site I dimer interface [polypeptide binding]; other site 394503008075 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 394503008076 Synaptic Flat tetramer interface [polypeptide binding]; other site 394503008077 Synaptic Site I dimer interface [polypeptide binding]; other site 394503008078 DNA binding site [nucleotide binding] 394503008079 Recombinase; Region: Recombinase; pfam07508 394503008080 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008081 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 394503008082 active site 394503008083 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503008084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 394503008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503008086 putative substrate translocation pore; other site 394503008087 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 394503008088 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 394503008089 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 394503008090 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 394503008091 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 394503008092 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 394503008093 Peptidase M16C associated; Region: M16C_assoc; pfam08367 394503008094 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 394503008095 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 394503008096 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 394503008097 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 394503008098 [2Fe-2S] cluster binding site [ion binding]; other site 394503008099 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 394503008100 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 394503008101 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 394503008102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503008103 catalytic residue [active] 394503008104 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 394503008105 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 394503008106 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 394503008107 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 394503008108 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 394503008109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503008110 active site 394503008111 phosphorylation site [posttranslational modification] 394503008112 intermolecular recognition site; other site 394503008113 dimerization interface [polypeptide binding]; other site 394503008114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503008115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 394503008116 HAMP domain; Region: HAMP; pfam00672 394503008117 Histidine kinase; Region: His_kinase; pfam06580 394503008118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503008119 ATP binding site [chemical binding]; other site 394503008120 Mg2+ binding site [ion binding]; other site 394503008121 G-X-G motif; other site 394503008122 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 394503008123 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 394503008124 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 394503008125 putative alpha-glucosidase; Provisional; Region: PRK10658 394503008126 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 394503008127 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 394503008128 active site 394503008129 homotrimer interface [polypeptide binding]; other site 394503008130 catalytic site [active] 394503008131 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 394503008132 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 394503008133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503008134 dimer interface [polypeptide binding]; other site 394503008135 conserved gate region; other site 394503008136 ABC-ATPase subunit interface; other site 394503008137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503008138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503008139 dimer interface [polypeptide binding]; other site 394503008140 conserved gate region; other site 394503008141 putative PBP binding loops; other site 394503008142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 394503008143 ABC-ATPase subunit interface; other site 394503008144 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503008145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503008146 Uncharacterized conserved protein [Function unknown]; Region: COG1434 394503008147 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 394503008148 putative active site [active] 394503008149 Sporulation and spore germination; Region: Germane; cl11253 394503008150 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 394503008151 active site 394503008152 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 394503008153 active site 2 [active] 394503008154 active site 1 [active] 394503008155 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 394503008156 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 394503008157 Catalytic site [active] 394503008158 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 394503008159 active site 394503008160 Trp docking motif [polypeptide binding]; other site 394503008161 PQQ-like domain; Region: PQQ_2; pfam13360 394503008162 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 394503008163 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 394503008164 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 394503008165 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 394503008166 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 394503008167 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 394503008168 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 394503008169 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 394503008170 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 394503008171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 394503008172 catalytic loop [active] 394503008173 iron binding site [ion binding]; other site 394503008174 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 394503008175 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 394503008176 4Fe-4S binding domain; Region: Fer4; pfam00037 394503008177 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 394503008178 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 394503008179 MutS domain III; Region: MutS_III; pfam05192 394503008180 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 394503008181 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 394503008182 Walker A/P-loop; other site 394503008183 ATP binding site [chemical binding]; other site 394503008184 Q-loop/lid; other site 394503008185 ABC transporter signature motif; other site 394503008186 Walker B; other site 394503008187 D-loop; other site 394503008188 H-loop/switch region; other site 394503008189 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 394503008190 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 394503008191 active site 394503008192 dimerization interface [polypeptide binding]; other site 394503008193 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 394503008194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503008195 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 394503008196 acyl-activating enzyme (AAE) consensus motif; other site 394503008197 putative AMP binding site [chemical binding]; other site 394503008198 putative active site [active] 394503008199 putative CoA binding site [chemical binding]; other site 394503008200 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 394503008201 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 394503008202 substrate binding pocket [chemical binding]; other site 394503008203 dimer interface [polypeptide binding]; other site 394503008204 inhibitor binding site; inhibition site 394503008205 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 394503008206 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 394503008207 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 394503008208 FAD binding site [chemical binding]; other site 394503008209 Putative motility protein; Region: YjfB_motility; pfam14070 394503008210 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 394503008211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 394503008212 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 394503008213 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 394503008214 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 394503008215 phosphopeptide binding site; other site 394503008216 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 394503008217 stage V sporulation protein B; Region: spore_V_B; TIGR02900 394503008218 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 394503008219 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 394503008220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503008221 active site 394503008222 motif I; other site 394503008223 motif II; other site 394503008224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 394503008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503008226 putative substrate translocation pore; other site 394503008227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503008228 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 394503008229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 394503008230 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 394503008231 Hemerythrin; Region: Hemerythrin; cd12107 394503008232 Fe binding site [ion binding]; other site 394503008233 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 394503008234 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 394503008235 NAD binding site [chemical binding]; other site 394503008236 dimer interface [polypeptide binding]; other site 394503008237 substrate binding site [chemical binding]; other site 394503008238 tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503008239 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 394503008240 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 394503008241 active site 394503008242 NAD binding site [chemical binding]; other site 394503008243 metal binding site [ion binding]; metal-binding site 394503008244 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 394503008245 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 394503008246 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 394503008247 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 394503008248 ATP binding site [chemical binding]; other site 394503008249 Mg++ binding site [ion binding]; other site 394503008250 motif III; other site 394503008251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503008252 nucleotide binding region [chemical binding]; other site 394503008253 ATP-binding site [chemical binding]; other site 394503008254 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 394503008255 RNA binding site [nucleotide binding]; other site 394503008256 Calx-beta domain; Region: Calx-beta; pfam03160 394503008257 Calx-beta domain; Region: Calx-beta; pfam03160 394503008258 Calx-beta domain; Region: Calx-beta; cl02522 394503008259 Calx-beta domain; Region: Calx-beta; cl02522 394503008260 Calx-beta domain; Region: Calx-beta; pfam03160 394503008261 S-layer homology domain; Region: SLH; pfam00395 394503008262 S-layer homology domain; Region: SLH; pfam00395 394503008263 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 394503008264 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 394503008265 Phage Tail Collar Domain; Region: Collar; pfam07484 394503008266 Phage Tail Collar Domain; Region: Collar; pfam07484 394503008267 Phage Tail Collar Domain; Region: Collar; pfam07484 394503008268 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 394503008269 dimer interface [polypeptide binding]; other site 394503008270 FMN binding site [chemical binding]; other site 394503008271 Hemerythrin-like domain; Region: Hr-like; cd12108 394503008272 Fe binding site [ion binding]; other site 394503008273 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 394503008274 TAP-like protein; Region: Abhydrolase_4; pfam08386 394503008275 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 394503008276 Na2 binding site [ion binding]; other site 394503008277 putative substrate binding site 1 [chemical binding]; other site 394503008278 Na binding site 1 [ion binding]; other site 394503008279 putative substrate binding site 2 [chemical binding]; other site 394503008280 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 394503008281 conserved hypothetical integral membrane protein; Region: TIGR03766 394503008282 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 394503008283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503008284 active site 394503008285 catalytic tetrad [active] 394503008286 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503008287 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 394503008288 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 394503008289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 394503008290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 394503008291 metal binding site [ion binding]; metal-binding site 394503008292 active site 394503008293 I-site; other site 394503008294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 394503008295 Zn2+ binding site [ion binding]; other site 394503008296 Mg2+ binding site [ion binding]; other site 394503008297 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 394503008298 putative active site; other site 394503008299 putative triphosphate binding site [ion binding]; other site 394503008300 putative metal binding residues [ion binding]; other site 394503008301 Phosphopantetheine attachment site; Region: PP-binding; cl09936 394503008302 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503008303 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 394503008304 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 394503008305 dimer interface [polypeptide binding]; other site 394503008306 active site 394503008307 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503008308 catalytic residues [active] 394503008309 substrate binding site [chemical binding]; other site 394503008310 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 394503008311 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 394503008312 active site 394503008313 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 394503008314 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 394503008315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 394503008316 acyl-activating enzyme (AAE) consensus motif; other site 394503008317 AMP binding site [chemical binding]; other site 394503008318 active site 394503008319 CoA binding site [chemical binding]; other site 394503008320 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 394503008321 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 394503008322 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 394503008323 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 394503008324 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 394503008325 active site 394503008326 metal binding site [ion binding]; metal-binding site 394503008327 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 394503008328 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 394503008329 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 394503008330 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 394503008331 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 394503008332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503008333 Walker A/P-loop; other site 394503008334 ATP binding site [chemical binding]; other site 394503008335 Q-loop/lid; other site 394503008336 ABC transporter signature motif; other site 394503008337 Walker B; other site 394503008338 D-loop; other site 394503008339 H-loop/switch region; other site 394503008340 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 394503008341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 394503008342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 394503008343 DNA binding residues [nucleotide binding] 394503008344 dimerization interface [polypeptide binding]; other site 394503008345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 394503008346 Beta-lactamase; Region: Beta-lactamase; pfam00144 394503008347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503008348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503008349 dimer interface [polypeptide binding]; other site 394503008350 putative CheW interface [polypeptide binding]; other site 394503008351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 394503008352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 394503008353 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 394503008354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 394503008355 putative substrate translocation pore; other site 394503008356 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 394503008357 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 394503008358 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 394503008359 putative sugar binding sites [chemical binding]; other site 394503008360 Q-X-W motif; other site 394503008361 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 394503008362 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 394503008363 diaminopimelate decarboxylase; Region: lysA; TIGR01048 394503008364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 394503008365 active site 394503008366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503008367 substrate binding site [chemical binding]; other site 394503008368 catalytic residues [active] 394503008369 dimer interface [polypeptide binding]; other site 394503008370 Predicted transcriptional regulators [Transcription]; Region: COG1378 394503008371 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 394503008372 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 394503008373 C-terminal domain interface [polypeptide binding]; other site 394503008374 sugar binding site [chemical binding]; other site 394503008375 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 394503008376 Protein of unknown function DUF58; Region: DUF58; pfam01882 394503008377 MoxR-like ATPases [General function prediction only]; Region: COG0714 394503008378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503008379 Walker A motif; other site 394503008380 ATP binding site [chemical binding]; other site 394503008381 Walker B motif; other site 394503008382 arginine finger; other site 394503008383 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 394503008384 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 394503008385 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 394503008386 Domain of unknown function DUF20; Region: UPF0118; pfam01594 394503008387 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 394503008388 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 394503008389 putative active site [active] 394503008390 putative metal binding site [ion binding]; other site 394503008391 flavodoxin; Provisional; Region: PRK06242 394503008392 putative oxidoreductase; Provisional; Region: PRK12831 394503008393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 394503008394 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 394503008395 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 394503008396 FAD binding pocket [chemical binding]; other site 394503008397 FAD binding motif [chemical binding]; other site 394503008398 phosphate binding motif [ion binding]; other site 394503008399 beta-alpha-beta structure motif; other site 394503008400 NAD binding pocket [chemical binding]; other site 394503008401 Iron coordination center [ion binding]; other site 394503008402 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 394503008403 Peptidase family M50; Region: Peptidase_M50; pfam02163 394503008404 active site 394503008405 putative substrate binding region [chemical binding]; other site 394503008406 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 394503008407 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503008408 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 394503008409 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 394503008410 cofactor binding site; other site 394503008411 DNA binding site [nucleotide binding] 394503008412 substrate interaction site [chemical binding]; other site 394503008413 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008414 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008415 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008416 Integrase core domain; Region: rve; pfam00665 394503008417 Integrase core domain; Region: rve_3; pfam13683 394503008418 GTP-binding protein Der; Reviewed; Region: PRK03003 394503008419 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008420 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008421 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008422 Integrase core domain; Region: rve; pfam00665 394503008423 Integrase core domain; Region: rve_3; pfam13683 394503008424 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 394503008425 substrate binding site [chemical binding]; other site 394503008426 Septum formation topological specificity factor MinE; Region: MinE; cl00538 394503008427 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 394503008428 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 394503008429 Switch I; other site 394503008430 Switch II; other site 394503008431 septum formation inhibitor; Reviewed; Region: minC; PRK00513 394503008432 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 394503008433 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 394503008434 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 394503008435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 394503008436 rod shape-determining protein MreC; Provisional; Region: PRK13922 394503008437 Protein of unknown function (DUF904); Region: DUF904; pfam06005 394503008438 rod shape-determining protein MreC; Region: MreC; pfam04085 394503008439 rod shape-determining protein MreB; Provisional; Region: PRK13927 394503008440 MreB and similar proteins; Region: MreB_like; cd10225 394503008441 nucleotide binding site [chemical binding]; other site 394503008442 Mg binding site [ion binding]; other site 394503008443 putative protofilament interaction site [polypeptide binding]; other site 394503008444 RodZ interaction site [polypeptide binding]; other site 394503008445 hypothetical protein; Reviewed; Region: PRK00024 394503008446 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 394503008447 MPN+ (JAMM) motif; other site 394503008448 Zinc-binding site [ion binding]; other site 394503008449 Maf-like protein; Region: Maf; pfam02545 394503008450 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 394503008451 active site 394503008452 dimer interface [polypeptide binding]; other site 394503008453 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 394503008454 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 394503008455 tartrate dehydrogenase; Provisional; Region: PRK08194 394503008456 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 394503008457 Found in ATP-dependent protease La (LON); Region: LON; smart00464 394503008458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503008459 Walker A motif; other site 394503008460 ATP binding site [chemical binding]; other site 394503008461 Walker B motif; other site 394503008462 arginine finger; other site 394503008463 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 394503008464 pyruvate kinase; Provisional; Region: PRK06354 394503008465 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 394503008466 domain interfaces; other site 394503008467 active site 394503008468 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 394503008469 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 394503008470 Na2 binding site [ion binding]; other site 394503008471 putative substrate binding site 1 [chemical binding]; other site 394503008472 Na binding site 1 [ion binding]; other site 394503008473 putative substrate binding site 2 [chemical binding]; other site 394503008474 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 394503008475 dimer interface [polypeptide binding]; other site 394503008476 Citrate synthase; Region: Citrate_synt; pfam00285 394503008477 active site 394503008478 citrylCoA binding site [chemical binding]; other site 394503008479 oxalacetate/citrate binding site [chemical binding]; other site 394503008480 coenzyme A binding site [chemical binding]; other site 394503008481 catalytic triad [active] 394503008482 hypothetical protein; Provisional; Region: PRK05590 394503008483 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 394503008484 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 394503008485 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 394503008486 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 394503008487 putative dimer interface [polypeptide binding]; other site 394503008488 putative anticodon binding site; other site 394503008489 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 394503008490 homodimer interface [polypeptide binding]; other site 394503008491 motif 1; other site 394503008492 motif 2; other site 394503008493 active site 394503008494 motif 3; other site 394503008495 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 394503008496 dimer interface [polypeptide binding]; other site 394503008497 active site 394503008498 isocitrate dehydrogenase; Validated; Region: PRK08299 394503008499 Putative glucoamylase; Region: Glycoamylase; pfam10091 394503008500 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 394503008501 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 394503008502 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 394503008503 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 394503008504 CoenzymeA binding site [chemical binding]; other site 394503008505 subunit interaction site [polypeptide binding]; other site 394503008506 PHB binding site; other site 394503008507 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 394503008508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503008509 FeS/SAM binding site; other site 394503008510 Pyruvate formate lyase 1; Region: PFL1; cd01678 394503008511 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 394503008512 coenzyme A binding site [chemical binding]; other site 394503008513 active site 394503008514 catalytic residues [active] 394503008515 glycine loop; other site 394503008516 Peptidase family M48; Region: Peptidase_M48; pfam01435 394503008517 isoaspartyl dipeptidase; Provisional; Region: PRK10657 394503008518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 394503008519 active site 394503008520 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 394503008521 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 394503008522 Walker A/P-loop; other site 394503008523 ATP binding site [chemical binding]; other site 394503008524 Q-loop/lid; other site 394503008525 ABC transporter signature motif; other site 394503008526 Walker B; other site 394503008527 D-loop; other site 394503008528 H-loop/switch region; other site 394503008529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 394503008530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503008531 dimer interface [polypeptide binding]; other site 394503008532 conserved gate region; other site 394503008533 putative PBP binding loops; other site 394503008534 ABC-ATPase subunit interface; other site 394503008535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 394503008536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 394503008537 substrate binding pocket [chemical binding]; other site 394503008538 membrane-bound complex binding site; other site 394503008539 hinge residues; other site 394503008540 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503008541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 394503008542 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 394503008543 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 394503008544 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 394503008545 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 394503008546 homotrimer interaction site [polypeptide binding]; other site 394503008547 putative active site [active] 394503008548 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 394503008549 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 394503008550 putative catalytic cysteine [active] 394503008551 glycerol kinase; Provisional; Region: glpK; PRK00047 394503008552 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 394503008553 N- and C-terminal domain interface [polypeptide binding]; other site 394503008554 active site 394503008555 MgATP binding site [chemical binding]; other site 394503008556 catalytic site [active] 394503008557 metal binding site [ion binding]; metal-binding site 394503008558 glycerol binding site [chemical binding]; other site 394503008559 homotetramer interface [polypeptide binding]; other site 394503008560 homodimer interface [polypeptide binding]; other site 394503008561 FBP binding site [chemical binding]; other site 394503008562 protein IIAGlc interface [polypeptide binding]; other site 394503008563 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 394503008564 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 394503008565 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 394503008566 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 394503008567 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 394503008568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503008569 FeS/SAM binding site; other site 394503008570 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 394503008571 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 394503008572 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 394503008573 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 394503008574 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 394503008575 Predicted transcriptional regulators [Transcription]; Region: COG1725 394503008576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503008577 DNA-binding site [nucleotide binding]; DNA binding site 394503008578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503008579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503008580 Walker A/P-loop; other site 394503008581 ATP binding site [chemical binding]; other site 394503008582 Q-loop/lid; other site 394503008583 ABC transporter signature motif; other site 394503008584 Walker B; other site 394503008585 D-loop; other site 394503008586 H-loop/switch region; other site 394503008587 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503008588 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 394503008589 Walker A/P-loop; other site 394503008590 ATP binding site [chemical binding]; other site 394503008591 Q-loop/lid; other site 394503008592 ABC transporter signature motif; other site 394503008593 Walker B; other site 394503008594 D-loop; other site 394503008595 H-loop/switch region; other site 394503008596 Predicted transcriptional regulators [Transcription]; Region: COG1725 394503008597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503008598 DNA-binding site [nucleotide binding]; DNA binding site 394503008599 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 394503008600 glycerate kinase; Region: TIGR00045 394503008601 6-phosphofructokinase; Provisional; Region: PRK03202 394503008602 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 394503008603 active site 394503008604 ADP/pyrophosphate binding site [chemical binding]; other site 394503008605 dimerization interface [polypeptide binding]; other site 394503008606 allosteric effector site; other site 394503008607 fructose-1,6-bisphosphate binding site; other site 394503008608 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 394503008609 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 394503008610 substrate binding site [chemical binding]; other site 394503008611 active site 394503008612 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 394503008613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503008614 S-adenosylmethionine binding site [chemical binding]; other site 394503008615 Acyltransferase family; Region: Acyl_transf_3; pfam01757 394503008616 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 394503008617 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 394503008618 NADP binding site [chemical binding]; other site 394503008619 homodimer interface [polypeptide binding]; other site 394503008620 active site 394503008621 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 394503008622 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 394503008623 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 394503008624 Transposase; Region: HTH_Tnp_1; pfam01527 394503008625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503008626 putative transposase OrfB; Reviewed; Region: PHA02517 394503008627 HTH-like domain; Region: HTH_21; pfam13276 394503008628 Integrase core domain; Region: rve; pfam00665 394503008629 Integrase core domain; Region: rve_3; pfam13683 394503008630 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 394503008631 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 394503008632 Dockerin type I repeat; Region: Dockerin_1; pfam00404 394503008633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503008634 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 394503008635 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 394503008636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503008637 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 394503008638 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 394503008639 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 394503008640 S-layer homology domain; Region: SLH; pfam00395 394503008641 Putative zinc-finger; Region: zf-HC2; pfam13490 394503008642 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 394503008643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503008644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503008645 DNA binding residues [nucleotide binding] 394503008646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503008647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503008648 dimer interface [polypeptide binding]; other site 394503008649 putative CheW interface [polypeptide binding]; other site 394503008650 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 394503008651 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 394503008652 DNA binding residues [nucleotide binding] 394503008653 drug binding residues [chemical binding]; other site 394503008654 dimer interface [polypeptide binding]; other site 394503008655 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 394503008656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503008657 ATP binding site [chemical binding]; other site 394503008658 Mg2+ binding site [ion binding]; other site 394503008659 G-X-G motif; other site 394503008660 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 394503008661 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 394503008662 active site 394503008663 catalytic residues [active] 394503008664 S-layer homology domain; Region: SLH; pfam00395 394503008665 S-layer homology domain; Region: SLH; pfam00395 394503008666 S-layer homology domain; Region: SLH; pfam00395 394503008667 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008668 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008669 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008670 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008671 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008672 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 394503008673 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 394503008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503008675 active site 394503008676 phosphorylation site [posttranslational modification] 394503008677 intermolecular recognition site; other site 394503008678 dimerization interface [polypeptide binding]; other site 394503008679 LytTr DNA-binding domain; Region: LytTR; pfam04397 394503008680 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 394503008681 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 394503008682 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 394503008683 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 394503008684 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 394503008685 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module [General function prediction only]; Region: COG1439 394503008686 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 394503008687 Amidase; Region: Amidase; cl11426 394503008688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503008689 Helix-turn-helix domain; Region: HTH_18; pfam12833 394503008690 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 394503008691 Predicted membrane protein [Function unknown]; Region: COG1289 394503008692 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 394503008693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503008694 dimerization interface [polypeptide binding]; other site 394503008695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 394503008696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503008697 dimer interface [polypeptide binding]; other site 394503008698 phosphorylation site [posttranslational modification] 394503008699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503008700 ATP binding site [chemical binding]; other site 394503008701 Mg2+ binding site [ion binding]; other site 394503008702 G-X-G motif; other site 394503008703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503008704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503008705 active site 394503008706 phosphorylation site [posttranslational modification] 394503008707 intermolecular recognition site; other site 394503008708 dimerization interface [polypeptide binding]; other site 394503008709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503008710 DNA binding site [nucleotide binding] 394503008711 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 394503008712 Beta-lactamase; Region: Beta-lactamase; pfam00144 394503008713 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 394503008714 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 394503008715 Walker A/P-loop; other site 394503008716 ATP binding site [chemical binding]; other site 394503008717 Q-loop/lid; other site 394503008718 ABC transporter signature motif; other site 394503008719 Walker B; other site 394503008720 D-loop; other site 394503008721 H-loop/switch region; other site 394503008722 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 394503008723 ABC-ATPase subunit interface; other site 394503008724 dimer interface [polypeptide binding]; other site 394503008725 putative PBP binding regions; other site 394503008726 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 394503008727 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 394503008728 ABC-ATPase subunit interface; other site 394503008729 dimer interface [polypeptide binding]; other site 394503008730 putative PBP binding regions; other site 394503008731 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 394503008732 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 394503008733 putative ligand binding residues [chemical binding]; other site 394503008734 Probable zinc-binding domain; Region: zf-trcl; pfam13451 394503008735 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 394503008736 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 394503008737 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 394503008738 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 394503008739 putative ligand binding site [chemical binding]; other site 394503008740 Putative esterase; Region: Esterase; pfam00756 394503008741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503008742 Radical SAM superfamily; Region: Radical_SAM; pfam04055 394503008743 FeS/SAM binding site; other site 394503008744 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 394503008745 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 394503008746 Helix-turn-helix domain; Region: HTH_18; pfam12833 394503008747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503008748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503008749 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503008750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503008751 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503008752 Transposase, Mutator family; Region: Transposase_mut; pfam00872 394503008753 MULE transposase domain; Region: MULE; pfam10551 394503008754 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008755 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008756 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008757 Integrase core domain; Region: rve; pfam00665 394503008758 Integrase core domain; Region: rve_3; pfam13683 394503008759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503008760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503008761 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 394503008762 VanZ like family; Region: VanZ; pfam04892 394503008763 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503008764 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 394503008765 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 394503008766 TM-ABC transporter signature motif; other site 394503008767 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008768 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008769 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008770 Integrase core domain; Region: rve; pfam00665 394503008771 Integrase core domain; Region: rve_3; pfam13683 394503008772 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 394503008773 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503008774 Walker A/P-loop; other site 394503008775 ATP binding site [chemical binding]; other site 394503008776 Q-loop/lid; other site 394503008777 ABC transporter signature motif; other site 394503008778 Walker B; other site 394503008779 D-loop; other site 394503008780 H-loop/switch region; other site 394503008781 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503008782 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 394503008783 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 394503008784 putative ligand binding site [chemical binding]; other site 394503008785 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 394503008786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503008787 DNA-binding site [nucleotide binding]; DNA binding site 394503008788 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 394503008789 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 394503008790 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 394503008791 Walker A/P-loop; other site 394503008792 ATP binding site [chemical binding]; other site 394503008793 Q-loop/lid; other site 394503008794 ABC transporter signature motif; other site 394503008795 Walker B; other site 394503008796 D-loop; other site 394503008797 H-loop/switch region; other site 394503008798 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 394503008799 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008800 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008801 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008802 Integrase core domain; Region: rve; pfam00665 394503008803 Integrase core domain; Region: rve_3; pfam13683 394503008804 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008805 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008806 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008807 Integrase core domain; Region: rve; pfam00665 394503008808 Integrase core domain; Region: rve_3; pfam13683 394503008809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503008810 Transposase; Region: HTH_Tnp_1; pfam01527 394503008811 Fic family protein [Function unknown]; Region: COG3177 394503008812 Fic/DOC family; Region: Fic; pfam02661 394503008813 Recombinase; Region: Recombinase; pfam07508 394503008814 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008815 Transposase; Region: HTH_Tnp_1; pfam01527 394503008816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503008817 HTH-like domain; Region: HTH_21; pfam13276 394503008818 Integrase core domain; Region: rve; pfam00665 394503008819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503008820 Transposase; Region: DEDD_Tnp_IS110; pfam01548 394503008821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 394503008822 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 394503008823 Transposase; Region: HTH_Tnp_1; pfam01527 394503008824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503008825 putative transposase OrfB; Reviewed; Region: PHA02517 394503008826 HTH-like domain; Region: HTH_21; pfam13276 394503008827 Integrase core domain; Region: rve; pfam00665 394503008828 Integrase core domain; Region: rve_3; pfam13683 394503008829 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 394503008830 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 394503008831 Walker A/P-loop; other site 394503008832 ATP binding site [chemical binding]; other site 394503008833 Q-loop/lid; other site 394503008834 ABC transporter signature motif; other site 394503008835 Walker B; other site 394503008836 D-loop; other site 394503008837 H-loop/switch region; other site 394503008838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503008839 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 394503008840 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 394503008841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503008842 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 394503008843 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 394503008844 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 394503008845 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503008846 Winged helix-turn helix; Region: HTH_29; pfam13551 394503008847 Homeodomain-like domain; Region: HTH_32; pfam13565 394503008848 Integrase core domain; Region: rve; pfam00665 394503008849 Integrase core domain; Region: rve_3; pfam13683 394503008850 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 394503008851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503008852 Walker A/P-loop; other site 394503008853 ATP binding site [chemical binding]; other site 394503008854 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 394503008855 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 394503008856 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 394503008857 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 394503008858 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 394503008859 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 394503008860 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 394503008861 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 394503008862 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 394503008863 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 394503008864 Int/Topo IB signature motif; other site 394503008865 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 394503008866 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 394503008867 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 394503008868 HsdM N-terminal domain; Region: HsdM_N; pfam12161 394503008869 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 394503008870 Methyltransferase domain; Region: Methyltransf_26; pfam13659 394503008871 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 394503008872 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 394503008873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503008874 ATP binding site [chemical binding]; other site 394503008875 putative Mg++ binding site [ion binding]; other site 394503008876 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503008877 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503008878 catalytic residues [active] 394503008879 catalytic nucleophile [active] 394503008880 Recombinase; Region: Recombinase; pfam07508 394503008881 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008882 Recombinase; Region: Recombinase; pfam07508 394503008883 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008884 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503008885 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503008886 catalytic residues [active] 394503008887 catalytic nucleophile [active] 394503008888 Recombinase; Region: Recombinase; pfam07508 394503008889 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008890 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503008891 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503008892 catalytic residues [active] 394503008893 catalytic nucleophile [active] 394503008894 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503008895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503008896 DNA binding residues [nucleotide binding] 394503008897 Helix-turn-helix domain; Region: HTH_36; pfam13730 394503008898 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 394503008899 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503008900 Walker A motif; other site 394503008901 ATP binding site [chemical binding]; other site 394503008902 Walker B motif; other site 394503008903 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 394503008904 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 394503008905 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 394503008906 active site 394503008907 metal binding site [ion binding]; metal-binding site 394503008908 interdomain interaction site; other site 394503008909 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 394503008910 arsenical-resistance protein; Region: acr3; TIGR00832 394503008911 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 394503008912 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503008913 NlpC/P60 family; Region: NLPC_P60; cl17555 394503008914 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 394503008915 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 394503008916 putative active site [active] 394503008917 putative NTP binding site [chemical binding]; other site 394503008918 putative nucleic acid binding site [nucleotide binding]; other site 394503008919 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 394503008920 active site 394503008921 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 394503008922 AAA-like domain; Region: AAA_10; pfam12846 394503008923 Domain of unknown function DUF87; Region: DUF87; pfam01935 394503008924 Pirin-related protein [General function prediction only]; Region: COG1741 394503008925 Pirin; Region: Pirin; pfam02678 394503008926 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 394503008927 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 394503008928 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 394503008929 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 394503008930 Colicin D; Region: Colicin_D; pfam11429 394503008931 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 394503008932 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 394503008933 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 394503008934 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503008935 Walker A motif; other site 394503008936 ATP binding site [chemical binding]; other site 394503008937 Walker B motif; other site 394503008938 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 394503008939 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 394503008940 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 394503008941 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 394503008942 SpoVG; Region: SpoVG; pfam04026 394503008943 YodL-like; Region: YodL; pfam14191 394503008944 S-layer homology domain; Region: SLH; pfam00395 394503008945 S-layer homology domain; Region: SLH; pfam00395 394503008946 S-layer homology domain; Region: SLH; pfam00395 394503008947 MraZ protein; Region: MraZ; pfam02381 394503008948 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 394503008949 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503008950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503008951 non-specific DNA binding site [nucleotide binding]; other site 394503008952 salt bridge; other site 394503008953 sequence-specific DNA binding site [nucleotide binding]; other site 394503008954 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 394503008955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503008956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503008957 non-specific DNA binding site [nucleotide binding]; other site 394503008958 salt bridge; other site 394503008959 sequence-specific DNA binding site [nucleotide binding]; other site 394503008960 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 394503008961 Accessory gene regulator B; Region: AgrB; pfam04647 394503008962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503008963 S-adenosylmethionine binding site [chemical binding]; other site 394503008964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 394503008965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 394503008966 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 394503008967 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 394503008968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503008969 NAD(P) binding site [chemical binding]; other site 394503008970 active site 394503008971 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 394503008972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503008973 NAD(P) binding site [chemical binding]; other site 394503008974 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 394503008975 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 394503008976 aminoglycoside resistance protein; Provisional; Region: PRK13746 394503008977 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 394503008978 active site 394503008979 NTP binding site [chemical binding]; other site 394503008980 metal binding triad [ion binding]; metal-binding site 394503008981 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 394503008982 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 394503008983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503008984 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 394503008985 Coenzyme A binding pocket [chemical binding]; other site 394503008986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503008987 S-adenosylmethionine binding site [chemical binding]; other site 394503008988 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 394503008989 active site 394503008990 NTP binding site [chemical binding]; other site 394503008991 metal binding triad [ion binding]; metal-binding site 394503008992 antibiotic binding site [chemical binding]; other site 394503008993 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503008994 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503008995 catalytic residues [active] 394503008996 catalytic nucleophile [active] 394503008997 Recombinase; Region: Recombinase; pfam07508 394503008998 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503008999 Recombinase; Region: Recombinase; pfam07508 394503009000 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503009001 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503009002 catalytic residues [active] 394503009003 catalytic nucleophile [active] 394503009004 Recombinase; Region: Recombinase; pfam07508 394503009005 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503009006 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 394503009007 amidase catalytic site [active] 394503009008 Zn binding residues [ion binding]; other site 394503009009 substrate binding site [chemical binding]; other site 394503009010 Sporulation related domain; Region: SPOR; pfam05036 394503009011 Holin family; Region: Phage_holin_4; pfam05105 394503009012 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 394503009013 active site 394503009014 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 394503009015 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 394503009016 Phage-related protein [Function unknown]; Region: COG4722 394503009017 Phage tail protein; Region: Sipho_tail; pfam05709 394503009018 Phage-related protein [Function unknown]; Region: COG5412 394503009019 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 394503009020 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 394503009021 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 394503009022 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 394503009023 oligomerization interface [polypeptide binding]; other site 394503009024 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 394503009025 Phage capsid family; Region: Phage_capsid; pfam05065 394503009026 Clp protease; Region: CLP_protease; pfam00574 394503009027 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 394503009028 oligomer interface [polypeptide binding]; other site 394503009029 active site residues [active] 394503009030 Phage-related protein [Function unknown]; Region: COG4695 394503009031 Phage portal protein; Region: Phage_portal; pfam04860 394503009032 Phage Terminase; Region: Terminase_1; pfam03354 394503009033 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 394503009034 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 394503009035 cofactor binding site; other site 394503009036 DNA binding site [nucleotide binding] 394503009037 substrate interaction site [chemical binding]; other site 394503009038 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 394503009039 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 394503009040 ParB-like nuclease domain; Region: ParB; smart00470 394503009041 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 394503009042 DNA methylase; Region: N6_N4_Mtase; pfam01555 394503009043 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 394503009044 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 394503009045 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 394503009046 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 394503009047 Phage terminase, small subunit; Region: Terminase_4; cl01525 394503009048 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 394503009049 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 394503009050 active site 394503009051 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 394503009052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503009053 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 394503009054 ATP binding site [chemical binding]; other site 394503009055 putative Mg++ binding site [ion binding]; other site 394503009056 VRR-NUC domain; Region: VRR_NUC; pfam08774 394503009057 Virulence-associated protein E; Region: VirE; pfam05272 394503009058 AntA/AntB antirepressor; Region: AntA; pfam08346 394503009059 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 394503009060 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 394503009061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 394503009062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 394503009063 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 394503009064 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 394503009065 active site 394503009066 DNA binding site [nucleotide binding] 394503009067 catalytic site [active] 394503009068 NUMOD4 motif; Region: NUMOD4; pfam07463 394503009069 HNH endonuclease; Region: HNH_3; pfam13392 394503009070 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 394503009071 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 394503009072 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 394503009073 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 394503009074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 394503009075 DNA binding residues [nucleotide binding] 394503009076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503009077 non-specific DNA binding site [nucleotide binding]; other site 394503009078 salt bridge; other site 394503009079 sequence-specific DNA binding site [nucleotide binding]; other site 394503009080 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 394503009081 non-specific DNA binding site [nucleotide binding]; other site 394503009082 salt bridge; other site 394503009083 sequence-specific DNA binding site [nucleotide binding]; other site 394503009084 Restriction endonuclease MspI; Region: Endonuc-MspI; pfam09208 394503009085 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 394503009086 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 394503009087 cofactor binding site; other site 394503009088 DNA binding site [nucleotide binding] 394503009089 substrate interaction site [chemical binding]; other site 394503009090 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 394503009091 TRAM domain; Region: TRAM; pfam01938 394503009092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503009093 S-adenosylmethionine binding site [chemical binding]; other site 394503009094 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 394503009095 active site 394503009096 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 394503009097 Membrane protein of unknown function; Region: DUF360; pfam04020 394503009098 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 394503009099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503009100 dimerization interface [polypeptide binding]; other site 394503009101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503009102 dimer interface [polypeptide binding]; other site 394503009103 putative CheW interface [polypeptide binding]; other site 394503009104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 394503009105 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503009106 Transglycosylase; Region: Transgly; pfam00912 394503009107 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 394503009108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 394503009109 gamma-glutamyl kinase; Provisional; Region: PRK05429 394503009110 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 394503009111 nucleotide binding site [chemical binding]; other site 394503009112 homotetrameric interface [polypeptide binding]; other site 394503009113 putative phosphate binding site [ion binding]; other site 394503009114 putative allosteric binding site; other site 394503009115 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 394503009116 active site 394503009117 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 394503009118 elongation factor G; Reviewed; Region: PRK12740 394503009119 G1 box; other site 394503009120 putative GEF interaction site [polypeptide binding]; other site 394503009121 GTP/Mg2+ binding site [chemical binding]; other site 394503009122 Switch I region; other site 394503009123 G2 box; other site 394503009124 G3 box; other site 394503009125 Switch II region; other site 394503009126 G4 box; other site 394503009127 G5 box; other site 394503009128 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 394503009129 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 394503009130 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 394503009131 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 394503009132 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 394503009133 prephenate dehydrogenase; Validated; Region: PRK06545 394503009134 prephenate dehydrogenase; Validated; Region: PRK08507 394503009135 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 394503009136 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 394503009137 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 394503009138 CoA binding domain; Region: CoA_binding; smart00881 394503009139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 394503009140 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 394503009141 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 394503009142 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 394503009143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503009144 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503009145 ABC transporter; Region: ABC_tran_2; pfam12848 394503009146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503009147 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 394503009148 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 394503009149 dimer interface [polypeptide binding]; other site 394503009150 active site 394503009151 CoA binding pocket [chemical binding]; other site 394503009152 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 394503009153 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 394503009154 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503009155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503009156 dimer interface [polypeptide binding]; other site 394503009157 putative CheW interface [polypeptide binding]; other site 394503009158 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 394503009159 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 394503009160 dimer interface [polypeptide binding]; other site 394503009161 active site 394503009162 CoA binding pocket [chemical binding]; other site 394503009163 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 394503009164 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503009165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503009166 dimer interface [polypeptide binding]; other site 394503009167 putative CheW interface [polypeptide binding]; other site 394503009168 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503009169 Winged helix-turn helix; Region: HTH_29; pfam13551 394503009170 Homeodomain-like domain; Region: HTH_32; pfam13565 394503009171 Integrase core domain; Region: rve; pfam00665 394503009172 Integrase core domain; Region: rve_3; pfam13683 394503009173 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503009174 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503009175 active site 394503009176 metal binding site [ion binding]; metal-binding site 394503009177 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 394503009178 active site 394503009179 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 394503009180 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 394503009181 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 394503009182 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 394503009183 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 394503009184 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 394503009185 Protein of unknown function (DUF964); Region: DUF964; pfam06133 394503009186 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 394503009187 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 394503009188 dimerization interface [polypeptide binding]; other site 394503009189 domain crossover interface; other site 394503009190 redox-dependent activation switch; other site 394503009191 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 394503009192 DNA-binding site [nucleotide binding]; DNA binding site 394503009193 RNA-binding motif; other site 394503009194 Methyltransferase domain; Region: Methyltransf_31; pfam13847 394503009195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503009196 S-adenosylmethionine binding site [chemical binding]; other site 394503009197 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503009198 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 394503009199 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 394503009200 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 394503009201 protein binding site [polypeptide binding]; other site 394503009202 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 394503009203 Catalytic dyad [active] 394503009204 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 394503009205 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503009206 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 394503009207 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 394503009208 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 394503009209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503009210 Walker A/P-loop; other site 394503009211 ATP binding site [chemical binding]; other site 394503009212 Q-loop/lid; other site 394503009213 ABC transporter signature motif; other site 394503009214 Walker B; other site 394503009215 D-loop; other site 394503009216 H-loop/switch region; other site 394503009217 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 394503009218 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 394503009219 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 394503009220 Walker A/P-loop; other site 394503009221 ATP binding site [chemical binding]; other site 394503009222 Q-loop/lid; other site 394503009223 ABC transporter signature motif; other site 394503009224 Walker B; other site 394503009225 D-loop; other site 394503009226 H-loop/switch region; other site 394503009227 TOBE domain; Region: TOBE; pfam03459 394503009228 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 394503009229 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 394503009230 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 394503009231 feedback inhibition sensing region; other site 394503009232 homohexameric interface [polypeptide binding]; other site 394503009233 nucleotide binding site [chemical binding]; other site 394503009234 N-acetyl-L-glutamate binding site [chemical binding]; other site 394503009235 acetylornithine aminotransferase; Provisional; Region: PRK02627 394503009236 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503009237 inhibitor-cofactor binding pocket; inhibition site 394503009238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503009239 catalytic residue [active] 394503009240 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 394503009241 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 394503009242 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 394503009243 catalytic site [active] 394503009244 subunit interface [polypeptide binding]; other site 394503009245 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 394503009246 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503009247 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 394503009248 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 394503009249 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 394503009250 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503009251 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 394503009252 IMP binding site; other site 394503009253 dimer interface [polypeptide binding]; other site 394503009254 interdomain contacts; other site 394503009255 partial ornithine binding site; other site 394503009256 ornithine carbamoyltransferase; Provisional; Region: PRK00779 394503009257 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 394503009258 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 394503009259 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 394503009260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 394503009261 Coenzyme A binding pocket [chemical binding]; other site 394503009262 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 394503009263 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 394503009264 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 394503009265 ACS interaction site; other site 394503009266 CODH interaction site; other site 394503009267 cubane metal cluster (B-cluster) [ion binding]; other site 394503009268 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 394503009269 Cupin domain; Region: Cupin_2; pfam07883 394503009270 Uncharacterized conserved protein [Function unknown]; Region: COG1284 394503009271 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 394503009272 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 394503009273 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 394503009274 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 394503009275 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503009276 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 394503009277 PemK-like protein; Region: PemK; pfam02452 394503009278 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 394503009279 alanine racemase; Reviewed; Region: alr; PRK00053 394503009280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 394503009281 active site 394503009282 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503009283 dimer interface [polypeptide binding]; other site 394503009284 substrate binding site [chemical binding]; other site 394503009285 catalytic residues [active] 394503009286 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 394503009287 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 394503009288 putative substrate binding site [chemical binding]; other site 394503009289 putative ATP binding site [chemical binding]; other site 394503009290 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 394503009291 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 394503009292 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 394503009293 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 394503009294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 394503009295 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 394503009296 O-Antigen ligase; Region: Wzy_C; cl04850 394503009297 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 394503009298 Predicted transcriptional regulators [Transcription]; Region: COG1695 394503009299 Transcriptional regulator PadR-like family; Region: PadR; cl17335 394503009300 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 394503009301 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 394503009302 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 394503009303 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 394503009304 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 394503009305 putative NADH binding site [chemical binding]; other site 394503009306 putative active site [active] 394503009307 nudix motif; other site 394503009308 putative metal binding site [ion binding]; other site 394503009309 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 394503009310 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 394503009311 putative dimer interface [polypeptide binding]; other site 394503009312 stage V sporulation protein B; Region: spore_V_B; TIGR02900 394503009313 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 394503009314 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503009315 NlpC/P60 family; Region: NLPC_P60; pfam00877 394503009316 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503009317 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503009318 active site 394503009319 metal binding site [ion binding]; metal-binding site 394503009320 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 394503009321 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 394503009322 FMN binding site [chemical binding]; other site 394503009323 active site 394503009324 catalytic residues [active] 394503009325 substrate binding site [chemical binding]; other site 394503009326 Holin family; Region: Phage_holin_4; pfam05105 394503009327 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 394503009328 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503009329 PemK-like protein; Region: PemK; pfam02452 394503009330 putative transposase OrfB; Reviewed; Region: PHA02517 394503009331 HTH-like domain; Region: HTH_21; pfam13276 394503009332 Integrase core domain; Region: rve; pfam00665 394503009333 Integrase core domain; Region: rve_3; pfam13683 394503009334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 394503009335 Transposase; Region: HTH_Tnp_1; pfam01527 394503009336 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 394503009337 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 394503009338 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 394503009339 oligomerization interface [polypeptide binding]; other site 394503009340 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 394503009341 Phage capsid family; Region: Phage_capsid; pfam05065 394503009342 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 394503009343 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 394503009344 Phage-related protein [Function unknown]; Region: COG4695; cl01923 394503009345 Phage Terminase; Region: Terminase_1; pfam03354 394503009346 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503009347 Winged helix-turn helix; Region: HTH_29; pfam13551 394503009348 Homeodomain-like domain; Region: HTH_32; pfam13565 394503009349 Integrase core domain; Region: rve; pfam00665 394503009350 Integrase core domain; Region: rve_3; pfam13683 394503009351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503009352 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 394503009353 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 394503009354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 394503009355 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 394503009356 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 394503009357 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 394503009358 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503009359 Winged helix-turn helix; Region: HTH_29; pfam13551 394503009360 Homeodomain-like domain; Region: HTH_32; pfam13565 394503009361 Integrase core domain; Region: rve; pfam00665 394503009362 Integrase core domain; Region: rve_3; pfam13683 394503009363 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 394503009364 Helix-turn-helix domain; Region: HTH_28; pfam13518 394503009365 Winged helix-turn helix; Region: HTH_29; pfam13551 394503009366 Homeodomain-like domain; Region: HTH_32; pfam13565 394503009367 Integrase core domain; Region: rve; pfam00665 394503009368 Integrase core domain; Region: rve_3; pfam13683 394503009369 YjcQ protein; Region: YjcQ; pfam09639 394503009370 Superinfection exclusion protein B; Region: SieB; pfam14163 394503009371 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 394503009372 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 394503009373 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 394503009374 active site 394503009375 catalytic residues [active] 394503009376 DNA binding site [nucleotide binding] 394503009377 Int/Topo IB signature motif; other site 394503009378 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 394503009379 stage II sporulation protein E; Region: spore_II_E; TIGR02865 394503009380 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 394503009381 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 394503009382 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 394503009383 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 394503009384 active site 394503009385 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 394503009386 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 394503009387 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 394503009388 protein binding site [polypeptide binding]; other site 394503009389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 394503009390 Protein of unknown function (DUF503); Region: DUF503; pfam04456 394503009391 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 394503009392 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 394503009393 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503009394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503009395 dimer interface [polypeptide binding]; other site 394503009396 conserved gate region; other site 394503009397 putative PBP binding loops; other site 394503009398 ABC-ATPase subunit interface; other site 394503009399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503009400 dimer interface [polypeptide binding]; other site 394503009401 conserved gate region; other site 394503009402 putative PBP binding loops; other site 394503009403 ABC-ATPase subunit interface; other site 394503009404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503009405 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 394503009406 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503009407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503009408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 394503009409 DNA binding site [nucleotide binding] 394503009410 domain linker motif; other site 394503009411 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 394503009412 putative dimerization interface [polypeptide binding]; other site 394503009413 putative ligand binding site [chemical binding]; other site 394503009414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503009415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 394503009416 DNA binding site [nucleotide binding] 394503009417 domain linker motif; other site 394503009418 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 394503009419 putative dimerization interface [polypeptide binding]; other site 394503009420 putative ligand binding site [chemical binding]; other site 394503009421 Domain of unknown function (DUF377); Region: DUF377; pfam04041 394503009422 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 394503009423 active site 394503009424 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 394503009425 dimerization interface [polypeptide binding]; other site 394503009426 putative active cleft [active] 394503009427 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 394503009428 active site 394503009429 TIGR03943 family protein; Region: TIGR03943 394503009430 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 394503009431 Predicted permeases [General function prediction only]; Region: COG0701 394503009432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 394503009433 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 394503009434 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 394503009435 metal binding site 2 [ion binding]; metal-binding site 394503009436 putative DNA binding helix; other site 394503009437 metal binding site 1 [ion binding]; metal-binding site 394503009438 dimer interface [polypeptide binding]; other site 394503009439 structural Zn2+ binding site [ion binding]; other site 394503009440 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 394503009441 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 394503009442 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 394503009443 Spore germination protein; Region: Spore_permease; cl17796 394503009444 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 394503009445 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 394503009446 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 394503009447 S-layer homology domain; Region: SLH; pfam00395 394503009448 S-layer homology domain; Region: SLH; pfam00395 394503009449 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 394503009450 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 394503009451 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 394503009452 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 394503009453 Phage-related protein [Function unknown]; Region: COG5412 394503009454 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 394503009455 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 394503009456 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 394503009457 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 394503009458 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 394503009459 Phage terminase large subunit; Region: Terminase_3; cl12054 394503009460 Terminase-like family; Region: Terminase_6; pfam03237 394503009461 Terminase small subunit; Region: Terminase_2; pfam03592 394503009462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503009463 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 394503009464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503009465 ATP binding site [chemical binding]; other site 394503009466 putative Mg++ binding site [ion binding]; other site 394503009467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 394503009468 nucleotide binding region [chemical binding]; other site 394503009469 ATP-binding site [chemical binding]; other site 394503009470 VRR-NUC domain; Region: VRR_NUC; pfam08774 394503009471 Virulence-associated protein E; Region: VirE; pfam05272 394503009472 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 394503009473 DNA methylase; Region: N6_N4_Mtase; cl17433 394503009474 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 394503009475 DNA methylase; Region: N6_N4_Mtase; pfam01555 394503009476 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 394503009477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503009478 ATP binding site [chemical binding]; other site 394503009479 putative Mg++ binding site [ion binding]; other site 394503009480 nucleotide binding region [chemical binding]; other site 394503009481 helicase superfamily c-terminal domain; Region: HELICc; smart00490 394503009482 ATP-binding site [chemical binding]; other site 394503009483 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 394503009484 active site 394503009485 substrate binding site [chemical binding]; other site 394503009486 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 394503009487 DNA binding site [nucleotide binding] 394503009488 active site 394503009489 catalytic site [active] 394503009490 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 394503009491 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 394503009492 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 394503009493 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 394503009494 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 394503009495 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 394503009496 NUMOD4 motif; Region: NUMOD4; pfam07463 394503009497 HNH endonuclease; Region: HNH_3; pfam13392 394503009498 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 394503009499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503009500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503009501 non-specific DNA binding site [nucleotide binding]; other site 394503009502 salt bridge; other site 394503009503 sequence-specific DNA binding site [nucleotide binding]; other site 394503009504 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503009505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503009506 non-specific DNA binding site [nucleotide binding]; other site 394503009507 salt bridge; other site 394503009508 sequence-specific DNA binding site [nucleotide binding]; other site 394503009509 Domain of unknown function (DUF955); Region: DUF955; pfam06114 394503009510 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503009511 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503009512 catalytic residues [active] 394503009513 catalytic nucleophile [active] 394503009514 Recombinase; Region: Recombinase; pfam07508 394503009515 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503009516 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 394503009517 active site 394503009518 hypothetical protein; Provisional; Region: PRK05807 394503009519 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 394503009520 RNA binding site [nucleotide binding]; other site 394503009521 Septum formation initiator; Region: DivIC; cl17659 394503009522 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 394503009523 YabP family; Region: YabP; cl06766 394503009524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 394503009525 RNA binding surface [nucleotide binding]; other site 394503009526 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 394503009527 IHF dimer interface [polypeptide binding]; other site 394503009528 IHF - DNA interface [nucleotide binding]; other site 394503009529 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 394503009530 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 394503009531 homodimer interface [polypeptide binding]; other site 394503009532 metal binding site [ion binding]; metal-binding site 394503009533 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 394503009534 homodimer interface [polypeptide binding]; other site 394503009535 active site 394503009536 putative chemical substrate binding site [chemical binding]; other site 394503009537 metal binding site [ion binding]; metal-binding site 394503009538 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 394503009539 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 394503009540 dimer interface [polypeptide binding]; other site 394503009541 ssDNA binding site [nucleotide binding]; other site 394503009542 tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503009543 stage V sporulation protein T; Region: spore_V_T; TIGR02851 394503009544 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 394503009545 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 394503009546 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 394503009547 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 394503009548 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 394503009549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503009550 ATP binding site [chemical binding]; other site 394503009551 putative Mg++ binding site [ion binding]; other site 394503009552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503009553 nucleotide binding region [chemical binding]; other site 394503009554 ATP-binding site [chemical binding]; other site 394503009555 TRCF domain; Region: TRCF; pfam03461 394503009556 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 394503009557 putative active site [active] 394503009558 catalytic residue [active] 394503009559 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 394503009560 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 394503009561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503009562 active site 394503009563 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357 394503009564 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 394503009565 active site 394503009566 substrate binding site [chemical binding]; other site 394503009567 CoA binding site [chemical binding]; other site 394503009568 regulatory protein SpoVG; Reviewed; Region: PRK13259 394503009569 pur operon repressor; Provisional; Region: PRK09213 394503009570 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 394503009571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 394503009572 active site 394503009573 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 394503009574 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 394503009575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 394503009576 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 394503009577 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 394503009578 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 394503009579 Rod binding protein; Region: Rod-binding; cl01626 394503009580 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 394503009581 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 394503009582 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 394503009583 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 394503009584 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 394503009585 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 394503009586 rod shape-determining protein Mbl; Provisional; Region: PRK13928 394503009587 MreB and similar proteins; Region: MreB_like; cd10225 394503009588 nucleotide binding site [chemical binding]; other site 394503009589 Mg binding site [ion binding]; other site 394503009590 putative protofilament interaction site [polypeptide binding]; other site 394503009591 RodZ interaction site [polypeptide binding]; other site 394503009592 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 394503009593 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 394503009594 G1 box; other site 394503009595 GTP/Mg2+ binding site [chemical binding]; other site 394503009596 Switch I region; other site 394503009597 G2 box; other site 394503009598 Switch II region; other site 394503009599 G3 box; other site 394503009600 G4 box; other site 394503009601 G5 box; other site 394503009602 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 394503009603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503009604 FeS/SAM binding site; other site 394503009605 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 394503009606 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 394503009607 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 394503009608 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 394503009609 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 394503009610 TrkA-C domain; Region: TrkA_C; pfam02080 394503009611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 394503009612 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 394503009613 catalytic residues [active] 394503009614 catalytic nucleophile [active] 394503009615 Recombinase; Region: Recombinase; pfam07508 394503009616 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 394503009617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503009618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503009619 non-specific DNA binding site [nucleotide binding]; other site 394503009620 salt bridge; other site 394503009621 sequence-specific DNA binding site [nucleotide binding]; other site 394503009622 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 394503009623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503009624 active site 394503009625 phosphorylation site [posttranslational modification] 394503009626 intermolecular recognition site; other site 394503009627 dimerization interface [polypeptide binding]; other site 394503009628 LytTr DNA-binding domain; Region: LytTR; smart00850 394503009629 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 394503009630 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 394503009631 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 394503009632 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 394503009633 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 394503009634 Helix-turn-helix domain; Region: HTH_36; pfam13730 394503009635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 394503009636 Peptidase family M23; Region: Peptidase_M23; pfam01551 394503009637 AAA-like domain; Region: AAA_10; pfam12846 394503009638 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 394503009639 S-layer homology domain; Region: SLH; pfam00395 394503009640 alpha-amylase; Reviewed; Region: malS; PRK09505 394503009641 hypothetical protein; Validated; Region: PRK00029 394503009642 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503009643 Walker A motif; other site 394503009644 ATP binding site [chemical binding]; other site 394503009645 Walker B motif; other site 394503009646 AAA domain; Region: AAA_31; pfam13614 394503009647 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 394503009648 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 394503009649 DNA-directed RNA polymerase subunit A'; Validated; Region: PRK08566 394503009650 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 394503009651 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 394503009652 DNA methylase; Region: N6_N4_Mtase; pfam01555 394503009653 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503009654 AAA-like domain; Region: AAA_10; pfam12846 394503009655 Walker A motif; other site 394503009656 ATP binding site [chemical binding]; other site 394503009657 Walker B motif; other site 394503009658 AAA-like domain; Region: AAA_10; pfam12846 394503009659 CHC2 zinc finger; Region: zf-CHC2; cl17510 394503009660 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 394503009661 Toprim-like; Region: Toprim_2; pfam13155 394503009662 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 394503009663 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 394503009664 ParB-like nuclease domain; Region: ParBc; pfam02195 394503009665 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 394503009666 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 394503009667 P-loop; other site 394503009668 Magnesium ion binding site [ion binding]; other site 394503009669 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 394503009670 Magnesium ion binding site [ion binding]; other site 394503009671 Uncharacterized conserved protein [Function unknown]; Region: COG4933 394503009672 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 394503009673 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 394503009674 active site 394503009675 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 394503009676 Methyltransferase domain; Region: Methyltransf_26; pfam13659 394503009677 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 394503009678 DEAD-like helicases superfamily; Region: DEXDc; smart00487 394503009679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 394503009680 ATP binding site [chemical binding]; other site 394503009681 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 394503009682 helicase superfamily c-terminal domain; Region: HELICc; smart00490 394503009683 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 394503009684 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 394503009685 glycosyltransferase, MGT family; Region: MGT; TIGR01426 394503009686 active site 394503009687 TDP-binding site; other site 394503009688 acceptor substrate-binding pocket; other site 394503009689 homodimer interface [polypeptide binding]; other site 394503009690 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 394503009691 seryl-tRNA synthetase; Provisional; Region: PRK05431 394503009692 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 394503009693 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 394503009694 motif 1; other site 394503009695 dimer interface [polypeptide binding]; other site 394503009696 active site 394503009697 motif 2; other site 394503009698 motif 3; other site 394503009699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 394503009700 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 394503009701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 394503009702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503009703 homodimer interface [polypeptide binding]; other site 394503009704 catalytic residue [active] 394503009705 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 394503009706 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 394503009707 dimer interface [polypeptide binding]; other site 394503009708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503009709 catalytic residue [active] 394503009710 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 394503009711 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 394503009712 Flavoprotein; Region: Flavoprotein; pfam02441 394503009713 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 394503009714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 394503009715 FeS/SAM binding site; other site 394503009716 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 394503009717 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 394503009718 pentamer interface [polypeptide binding]; other site 394503009719 dodecaamer interface [polypeptide binding]; other site 394503009720 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503009721 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 394503009722 substrate binding site [chemical binding]; other site 394503009723 ATP binding site [chemical binding]; other site 394503009724 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 394503009725 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 394503009726 active site 394503009727 intersubunit interface [polypeptide binding]; other site 394503009728 catalytic residue [active] 394503009729 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 394503009730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503009731 DNA-binding site [nucleotide binding]; DNA binding site 394503009732 FCD domain; Region: FCD; pfam07729 394503009733 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 394503009734 catalytic triad [active] 394503009735 putative active site [active] 394503009736 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 394503009737 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 394503009738 putative catalytic cysteine [active] 394503009739 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 394503009740 putative active site [active] 394503009741 metal binding site [ion binding]; metal-binding site 394503009742 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 394503009743 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 394503009744 B12 binding site [chemical binding]; other site 394503009745 cobalt ligand [ion binding]; other site 394503009746 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 394503009747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 394503009748 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 394503009749 catalytic loop [active] 394503009750 iron binding site [ion binding]; other site 394503009751 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 394503009752 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 394503009753 Walker A/P-loop; other site 394503009754 ATP binding site [chemical binding]; other site 394503009755 Q-loop/lid; other site 394503009756 ABC transporter signature motif; other site 394503009757 Walker B; other site 394503009758 D-loop; other site 394503009759 H-loop/switch region; other site 394503009760 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 394503009761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 394503009762 ABC-ATPase subunit interface; other site 394503009763 dimer interface [polypeptide binding]; other site 394503009764 putative PBP binding regions; other site 394503009765 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 394503009766 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 394503009767 intersubunit interface [polypeptide binding]; other site 394503009768 phosphopentomutase; Provisional; Region: PRK05362 394503009769 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 394503009770 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 394503009771 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 394503009772 putative active site [active] 394503009773 putative metal binding site [ion binding]; other site 394503009774 Sulfatase; Region: Sulfatase; cl17466 394503009775 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 394503009776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503009777 binding surface 394503009778 TPR motif; other site 394503009779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 394503009780 binding surface 394503009781 TPR repeat; Region: TPR_11; pfam13414 394503009782 TPR motif; other site 394503009783 TPR repeat; Region: TPR_11; pfam13414 394503009784 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 394503009785 active site 394503009786 catalytic triad [active] 394503009787 oxyanion hole [active] 394503009788 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 394503009789 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 394503009790 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 394503009791 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 394503009792 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 394503009793 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 394503009794 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 394503009795 glutamine binding [chemical binding]; other site 394503009796 catalytic triad [active] 394503009797 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 394503009798 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 394503009799 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 394503009800 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 394503009801 active site 394503009802 ribulose/triose binding site [chemical binding]; other site 394503009803 phosphate binding site [ion binding]; other site 394503009804 substrate (anthranilate) binding pocket [chemical binding]; other site 394503009805 product (indole) binding pocket [chemical binding]; other site 394503009806 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 394503009807 active site 394503009808 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 394503009809 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 394503009810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503009811 catalytic residue [active] 394503009812 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 394503009813 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 394503009814 substrate binding site [chemical binding]; other site 394503009815 active site 394503009816 catalytic residues [active] 394503009817 heterodimer interface [polypeptide binding]; other site 394503009818 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503009819 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 394503009820 active site 394503009821 catalytic tetrad [active] 394503009822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 394503009823 hexokinase; Provisional; Region: PTZ00107 394503009824 Hexokinase; Region: Hexokinase_2; pfam03727 394503009825 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 394503009826 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 394503009827 active site 394503009828 metal binding site [ion binding]; metal-binding site 394503009829 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 394503009830 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 394503009831 NAD(P) binding site [chemical binding]; other site 394503009832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 394503009833 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 394503009834 substrate binding site [chemical binding]; other site 394503009835 dimer interface [polypeptide binding]; other site 394503009836 ATP binding site [chemical binding]; other site 394503009837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503009838 dimerization interface [polypeptide binding]; other site 394503009839 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503009840 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503009841 dimer interface [polypeptide binding]; other site 394503009842 putative CheW interface [polypeptide binding]; other site 394503009843 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 394503009844 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 394503009845 synthetase active site [active] 394503009846 NTP binding site [chemical binding]; other site 394503009847 metal binding site [ion binding]; metal-binding site 394503009848 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 394503009849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 394503009850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 394503009851 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 394503009852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503009853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 394503009854 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 394503009855 Fe-S cluster binding site [ion binding]; other site 394503009856 active site 394503009857 BioY family; Region: BioY; pfam02632 394503009858 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 394503009859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503009860 dimerization interface [polypeptide binding]; other site 394503009861 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 394503009862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 394503009863 dimer interface [polypeptide binding]; other site 394503009864 putative CheW interface [polypeptide binding]; other site 394503009865 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 394503009866 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 394503009867 NAD binding site [chemical binding]; other site 394503009868 homodimer interface [polypeptide binding]; other site 394503009869 active site 394503009870 substrate binding site [chemical binding]; other site 394503009871 galactokinase; Provisional; Region: PRK05322 394503009872 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 394503009873 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 394503009874 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 394503009875 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 394503009876 active site 394503009877 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 394503009878 metal binding site [ion binding]; metal-binding site 394503009879 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 394503009880 putative metal binding site [ion binding]; other site 394503009881 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 394503009882 putative metal binding site [ion binding]; other site 394503009883 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 394503009884 putative metal binding site [ion binding]; other site 394503009885 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 394503009886 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 394503009887 putative sugar binding sites [chemical binding]; other site 394503009888 Q-X-W motif; other site 394503009889 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 394503009890 S-layer homology domain; Region: SLH; pfam00395 394503009891 S-layer homology domain; Region: SLH; pfam00395 394503009892 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 394503009893 active site 394503009894 catalytic residues [active] 394503009895 beta-phosphoglucomutase; Region: bPGM; TIGR01990 394503009896 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 394503009897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 394503009898 motif II; other site 394503009899 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 394503009900 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 394503009901 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 394503009902 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 394503009903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 394503009904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503009905 dimer interface [polypeptide binding]; other site 394503009906 conserved gate region; other site 394503009907 putative PBP binding loops; other site 394503009908 ABC-ATPase subunit interface; other site 394503009909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503009910 dimer interface [polypeptide binding]; other site 394503009911 conserved gate region; other site 394503009912 putative PBP binding loops; other site 394503009913 ABC-ATPase subunit interface; other site 394503009914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503009915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503009916 S-layer homology domain; Region: SLH; pfam00395 394503009917 S-layer homology domain; Region: SLH; pfam00395 394503009918 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 394503009919 dimerization interface [polypeptide binding]; other site 394503009920 Histidine kinase; Region: His_kinase; pfam06580 394503009921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503009922 ATP binding site [chemical binding]; other site 394503009923 Mg2+ binding site [ion binding]; other site 394503009924 G-X-G motif; other site 394503009925 Response regulator receiver domain; Region: Response_reg; pfam00072 394503009926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503009927 active site 394503009928 phosphorylation site [posttranslational modification] 394503009929 intermolecular recognition site; other site 394503009930 dimerization interface [polypeptide binding]; other site 394503009931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503009932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503009933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503009934 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 394503009935 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 394503009936 active site 394503009937 catalytic tetrad [active] 394503009938 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503009939 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 394503009940 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 394503009941 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 394503009942 acyl-activating enzyme (AAE) consensus motif; other site 394503009943 AMP binding site [chemical binding]; other site 394503009944 active site 394503009945 CoA binding site [chemical binding]; other site 394503009946 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 394503009947 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 394503009948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 394503009949 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 394503009950 dimer interface [polypeptide binding]; other site 394503009951 active site 394503009952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 394503009953 catalytic residues [active] 394503009954 substrate binding site [chemical binding]; other site 394503009955 acyl carrier protein; Provisional; Region: PRK07081 394503009956 biotin carboxylase-like protein; Validated; Region: PRK06524 394503009957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 394503009958 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 394503009959 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 394503009960 Ligand Binding Site [chemical binding]; other site 394503009961 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 394503009962 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 394503009963 inhibitor-cofactor binding pocket; inhibition site 394503009964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503009965 catalytic residue [active] 394503009966 Chorismate lyase; Region: Chor_lyase; cl01230 394503009967 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 394503009968 ABC-2 type transporter; Region: ABC2_membrane; cl17235 394503009969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 394503009970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503009971 Walker A/P-loop; other site 394503009972 ATP binding site [chemical binding]; other site 394503009973 Q-loop/lid; other site 394503009974 ABC transporter signature motif; other site 394503009975 Walker B; other site 394503009976 D-loop; other site 394503009977 H-loop/switch region; other site 394503009978 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 394503009979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503009980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 394503009981 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 394503009982 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 394503009983 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 394503009984 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 394503009985 Transposase IS200 like; Region: Y1_Tnp; pfam01797 394503009986 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 394503009987 Phage-related protein [Function unknown]; Region: COG5412 394503009988 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 394503009989 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 394503009990 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 394503009991 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 394503009992 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 394503009993 Phage terminase large subunit; Region: Terminase_3; cl12054 394503009994 Terminase-like family; Region: Terminase_6; pfam03237 394503009995 Terminase small subunit; Region: Terminase_2; pfam03592 394503009996 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 394503009997 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 394503009998 DNA binding residues [nucleotide binding] 394503009999 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 394503010000 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 394503010001 AAA domain; Region: AAA_25; pfam13481 394503010002 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 394503010003 Walker A motif; other site 394503010004 ATP binding site [chemical binding]; other site 394503010005 Walker B motif; other site 394503010006 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 394503010007 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 394503010008 ParB-like nuclease domain; Region: ParBc; pfam02195 394503010009 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 394503010010 DEAD-like helicases superfamily; Region: DEXDc; smart00487 394503010011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503010012 putative Mg++ binding site [ion binding]; other site 394503010013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503010014 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 394503010015 nucleotide binding region [chemical binding]; other site 394503010016 ATP-binding site [chemical binding]; other site 394503010017 AAA domain; Region: AAA_24; pfam13479 394503010018 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 394503010019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 394503010020 AAA domain; Region: AAA_23; pfam13476 394503010021 Walker A/P-loop; other site 394503010022 ATP binding site [chemical binding]; other site 394503010023 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 394503010024 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 394503010025 Helix-turn-helix domain; Region: HTH_17; pfam12728 394503010026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503010027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503010028 non-specific DNA binding site [nucleotide binding]; other site 394503010029 salt bridge; other site 394503010030 sequence-specific DNA binding site [nucleotide binding]; other site 394503010031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 394503010032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503010033 non-specific DNA binding site [nucleotide binding]; other site 394503010034 salt bridge; other site 394503010035 sequence-specific DNA binding site [nucleotide binding]; other site 394503010036 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 394503010037 Catalytic site [active] 394503010038 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 394503010039 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 394503010040 Int/Topo IB signature motif; other site 394503010041 RNA polymerase factor sigma-70; Validated; Region: PRK08295 394503010042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 394503010043 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 394503010044 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 394503010045 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 394503010046 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 394503010047 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 394503010048 active site 394503010049 metal binding site [ion binding]; metal-binding site 394503010050 dimerization interface [polypeptide binding]; other site 394503010051 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 394503010052 active site 394503010053 putative catalytic site [active] 394503010054 DNA binding site [nucleotide binding] 394503010055 putative phosphate binding site [ion binding]; other site 394503010056 metal binding site A [ion binding]; metal-binding site 394503010057 AP binding site [nucleotide binding]; other site 394503010058 metal binding site B [ion binding]; metal-binding site 394503010059 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 394503010060 NlpC/P60 family; Region: NLPC_P60; cl17555 394503010061 Bacterial SH3 domain; Region: SH3_3; pfam08239 394503010062 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 394503010063 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 394503010064 active site 394503010065 HIGH motif; other site 394503010066 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 394503010067 KMSKS motif; other site 394503010068 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 394503010069 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 394503010070 serine O-acetyltransferase; Region: cysE; TIGR01172 394503010071 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 394503010072 trimer interface [polypeptide binding]; other site 394503010073 active site 394503010074 substrate binding site [chemical binding]; other site 394503010075 CoA binding site [chemical binding]; other site 394503010076 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 394503010077 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 394503010078 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 394503010079 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 394503010080 minor groove reading motif; other site 394503010081 helix-hairpin-helix signature motif; other site 394503010082 substrate binding pocket [chemical binding]; other site 394503010083 active site 394503010084 Homoserine O-succinyltransferase; Region: HTS; pfam04204 394503010085 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 394503010086 proposed active site lysine [active] 394503010087 conserved cys residue [active] 394503010088 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 394503010089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 394503010090 homodimer interface [polypeptide binding]; other site 394503010091 substrate-cofactor binding pocket; other site 394503010092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 394503010093 catalytic residue [active] 394503010094 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 394503010095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 394503010096 dimer interface [polypeptide binding]; other site 394503010097 conserved gate region; other site 394503010098 ABC-ATPase subunit interface; other site 394503010099 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 394503010100 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 394503010101 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 394503010102 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 394503010103 Walker A/P-loop; other site 394503010104 ATP binding site [chemical binding]; other site 394503010105 Q-loop/lid; other site 394503010106 ABC transporter signature motif; other site 394503010107 Walker B; other site 394503010108 D-loop; other site 394503010109 H-loop/switch region; other site 394503010110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 394503010111 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 394503010112 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503010113 DNA-binding site [nucleotide binding]; DNA binding site 394503010114 TrkA-C domain; Region: TrkA_C; pfam02080 394503010115 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 394503010116 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 394503010117 dimer interface [polypeptide binding]; other site 394503010118 active site 394503010119 metal binding site [ion binding]; metal-binding site 394503010120 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 394503010121 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 394503010122 DNA binding residues [nucleotide binding] 394503010123 putative dimer interface [polypeptide binding]; other site 394503010124 Asp23 family; Region: Asp23; pfam03780 394503010125 YtxC-like family; Region: YtxC; pfam08812 394503010126 Uncharacterized conserved protein [Function unknown]; Region: COG2155 394503010127 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503010128 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 394503010129 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 394503010130 flagellar operon protein TIGR03826; Region: YvyF 394503010131 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 394503010132 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 394503010133 active site 394503010134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 394503010135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 394503010136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 394503010137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 394503010138 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 394503010139 Walker A/P-loop; other site 394503010140 ATP binding site [chemical binding]; other site 394503010141 Q-loop/lid; other site 394503010142 ABC transporter signature motif; other site 394503010143 Walker B; other site 394503010144 D-loop; other site 394503010145 H-loop/switch region; other site 394503010146 Hemerythrin-like domain; Region: Hr-like; cd12108 394503010147 Fe binding site [ion binding]; other site 394503010148 PAS domain; Region: PAS_10; pfam13596 394503010149 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 394503010150 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 394503010151 Mechanosensitive ion channel; Region: MS_channel; pfam00924 394503010152 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 394503010153 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 394503010154 catalytic triad [active] 394503010155 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 394503010156 Rubredoxin; Region: Rubredoxin; pfam00301 394503010157 iron binding site [ion binding]; other site 394503010158 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 394503010159 PAS domain S-box; Region: sensory_box; TIGR00229 394503010160 PAS domain; Region: PAS; smart00091 394503010161 putative active site [active] 394503010162 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 394503010163 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 394503010164 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 394503010165 active site 394503010166 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 394503010167 G1 box; other site 394503010168 GTP/Mg2+ binding site [chemical binding]; other site 394503010169 G2 box; other site 394503010170 Switch I region; other site 394503010171 G3 box; other site 394503010172 Switch II region; other site 394503010173 G4 box; other site 394503010174 G5 box; other site 394503010175 Predicted membrane protein [Function unknown]; Region: COG2860 394503010176 UPF0126 domain; Region: UPF0126; pfam03458 394503010177 UPF0126 domain; Region: UPF0126; pfam03458 394503010178 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 394503010179 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 394503010180 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 394503010181 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 394503010182 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 394503010183 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 394503010184 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 394503010185 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 394503010186 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 394503010187 NADH dehydrogenase; Region: NADHdh; cl00469 394503010188 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 394503010189 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 394503010190 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 394503010191 Domain of unknown function DUF20; Region: UPF0118; pfam01594 394503010192 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 394503010193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503010194 S-adenosylmethionine binding site [chemical binding]; other site 394503010195 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 394503010196 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 394503010197 transcription termination factor Rho; Provisional; Region: PRK12678 394503010198 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 394503010199 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 394503010200 RNA binding site [nucleotide binding]; other site 394503010201 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 394503010202 multimer interface [polypeptide binding]; other site 394503010203 Walker A motif; other site 394503010204 ATP binding site [chemical binding]; other site 394503010205 Walker B motif; other site 394503010206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 394503010207 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 394503010208 active site 394503010209 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 394503010210 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 394503010211 Sulfatase; Region: Sulfatase; pfam00884 394503010212 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 394503010213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 394503010214 putative active site [active] 394503010215 heme pocket [chemical binding]; other site 394503010216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503010217 ATP binding site [chemical binding]; other site 394503010218 Mg2+ binding site [ion binding]; other site 394503010219 G-X-G motif; other site 394503010220 arginine deiminase; Provisional; Region: PRK01388 394503010221 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 394503010222 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 394503010223 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 394503010224 A new structural DNA glycosylase; Region: AlkD_like; cd06561 394503010225 active site 394503010226 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 394503010227 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 394503010228 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 394503010229 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 394503010230 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 394503010231 hinge; other site 394503010232 active site 394503010233 YycH protein; Region: YycI; pfam09648 394503010234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 394503010235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 394503010236 dimerization interface [polypeptide binding]; other site 394503010237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 394503010238 dimer interface [polypeptide binding]; other site 394503010239 phosphorylation site [posttranslational modification] 394503010240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503010241 ATP binding site [chemical binding]; other site 394503010242 Mg2+ binding site [ion binding]; other site 394503010243 G-X-G motif; other site 394503010244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 394503010245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 394503010246 active site 394503010247 phosphorylation site [posttranslational modification] 394503010248 intermolecular recognition site; other site 394503010249 dimerization interface [polypeptide binding]; other site 394503010250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 394503010251 DNA binding site [nucleotide binding] 394503010252 Outer membrane efflux protein; Region: OEP; pfam02321 394503010253 Outer membrane efflux protein; Region: OEP; pfam02321 394503010254 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 394503010255 S-layer homology domain; Region: SLH; pfam00395 394503010256 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 394503010257 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 394503010258 ligand binding site; other site 394503010259 oligomer interface; other site 394503010260 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 394503010261 dimer interface [polypeptide binding]; other site 394503010262 N-terminal domain interface [polypeptide binding]; other site 394503010263 sulfate 1 binding site; other site 394503010264 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 394503010265 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 394503010266 ligand binding site; other site 394503010267 oligomer interface; other site 394503010268 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 394503010269 dimer interface [polypeptide binding]; other site 394503010270 N-terminal domain interface [polypeptide binding]; other site 394503010271 sulfate 1 binding site; other site 394503010272 glutamate racemase; Provisional; Region: PRK00865 394503010273 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 394503010274 Ligand Binding Site [chemical binding]; other site 394503010275 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 394503010276 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 394503010277 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 394503010278 active site 394503010279 tetramer interface; other site 394503010280 Predicted membrane protein [Function unknown]; Region: COG3601 394503010281 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 394503010282 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 394503010283 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 394503010284 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 394503010285 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 394503010286 TraB family; Region: TraB; pfam01963 394503010287 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 394503010288 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 394503010289 catalytic domain interface [polypeptide binding]; other site 394503010290 putative homodimer interface [polypeptide binding]; other site 394503010291 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 394503010292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 394503010293 ABC-ATPase subunit interface; other site 394503010294 dimer interface [polypeptide binding]; other site 394503010295 putative PBP binding regions; other site 394503010296 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 394503010297 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 394503010298 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 394503010299 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 394503010300 TPP-binding site [chemical binding]; other site 394503010301 dimer interface [polypeptide binding]; other site 394503010302 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 394503010303 PYR/PP interface [polypeptide binding]; other site 394503010304 dimer interface [polypeptide binding]; other site 394503010305 TPP binding site [chemical binding]; other site 394503010306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 394503010307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 394503010308 salt bridge; other site 394503010309 non-specific DNA binding site [nucleotide binding]; other site 394503010310 sequence-specific DNA binding site [nucleotide binding]; other site 394503010311 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 394503010312 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 394503010313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 394503010314 Walker A motif; other site 394503010315 ATP binding site [chemical binding]; other site 394503010316 Walker B motif; other site 394503010317 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 394503010318 active site 394503010319 Zn binding site [ion binding]; other site 394503010320 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 394503010321 Part of AAA domain; Region: AAA_19; pfam13245 394503010322 Family description; Region: UvrD_C_2; pfam13538 394503010323 Methyltransferase domain; Region: Methyltransf_23; pfam13489 394503010324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503010325 S-adenosylmethionine binding site [chemical binding]; other site 394503010326 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 394503010327 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 394503010328 putative ligand binding site [chemical binding]; other site 394503010329 putative NAD binding site [chemical binding]; other site 394503010330 catalytic site [active] 394503010331 alpha-galactosidase; Provisional; Region: PRK15076 394503010332 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 394503010333 NAD binding site [chemical binding]; other site 394503010334 sugar binding site [chemical binding]; other site 394503010335 divalent metal binding site [ion binding]; other site 394503010336 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 394503010337 dimer interface [polypeptide binding]; other site 394503010338 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 394503010339 FMN binding site [chemical binding]; other site 394503010340 dimer interface [polypeptide binding]; other site 394503010341 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 394503010342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503010343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 394503010344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 394503010345 xylose isomerase; Provisional; Region: PRK05474 394503010346 xylose isomerase; Region: xylose_isom_A; TIGR02630 394503010347 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 394503010348 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 394503010349 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 394503010350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 394503010351 nucleotide binding site [chemical binding]; other site 394503010352 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 394503010353 N- and C-terminal domain interface [polypeptide binding]; other site 394503010354 D-xylulose kinase; Region: XylB; TIGR01312 394503010355 active site 394503010356 MgATP binding site [chemical binding]; other site 394503010357 catalytic site [active] 394503010358 metal binding site [ion binding]; metal-binding site 394503010359 xylulose binding site [chemical binding]; other site 394503010360 homodimer interface [polypeptide binding]; other site 394503010361 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 394503010362 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 394503010363 active site 394503010364 catalytic residues [active] 394503010365 metal binding site [ion binding]; metal-binding site 394503010366 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 394503010367 2-isopropylmalate synthase; Validated; Region: PRK00915 394503010368 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 394503010369 active site 394503010370 catalytic residues [active] 394503010371 metal binding site [ion binding]; metal-binding site 394503010372 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 394503010373 ketol-acid reductoisomerase; Provisional; Region: PRK05479 394503010374 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 394503010375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 394503010376 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 394503010377 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 394503010378 putative valine binding site [chemical binding]; other site 394503010379 dimer interface [polypeptide binding]; other site 394503010380 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 394503010381 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 394503010382 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 394503010383 PYR/PP interface [polypeptide binding]; other site 394503010384 dimer interface [polypeptide binding]; other site 394503010385 TPP binding site [chemical binding]; other site 394503010386 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 394503010387 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 394503010388 TPP-binding site [chemical binding]; other site 394503010389 dimer interface [polypeptide binding]; other site 394503010390 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 394503010391 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 394503010392 inhibitor binding site; inhibition site 394503010393 active site 394503010394 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 394503010395 nucleoside/Zn binding site; other site 394503010396 dimer interface [polypeptide binding]; other site 394503010397 catalytic motif [active] 394503010398 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 394503010399 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 394503010400 NADP-binding site; other site 394503010401 homotetramer interface [polypeptide binding]; other site 394503010402 substrate binding site [chemical binding]; other site 394503010403 homodimer interface [polypeptide binding]; other site 394503010404 active site 394503010405 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 394503010406 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 394503010407 NADP binding site [chemical binding]; other site 394503010408 active site 394503010409 putative substrate binding site [chemical binding]; other site 394503010410 DivIVA protein; Region: DivIVA; pfam05103 394503010411 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 394503010412 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 394503010413 GDP-Fucose binding site [chemical binding]; other site 394503010414 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 394503010415 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 394503010416 GDP-Fucose binding site [chemical binding]; other site 394503010417 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 394503010418 GDP-Fucose binding site [chemical binding]; other site 394503010419 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 394503010420 active site 394503010421 catalytic triad [active] 394503010422 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 394503010423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 394503010424 NAD(P) binding site [chemical binding]; other site 394503010425 active site 394503010426 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 394503010427 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 394503010428 alpha subunit interface [polypeptide binding]; other site 394503010429 TPP binding site [chemical binding]; other site 394503010430 heterodimer interface [polypeptide binding]; other site 394503010431 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 394503010432 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 394503010433 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 394503010434 tetramer interface [polypeptide binding]; other site 394503010435 TPP-binding site [chemical binding]; other site 394503010436 heterodimer interface [polypeptide binding]; other site 394503010437 phosphorylation loop region [posttranslational modification] 394503010438 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 394503010439 GDP-Fucose binding site [chemical binding]; other site 394503010440 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 394503010441 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 394503010442 Substrate binding site; other site 394503010443 Cupin domain; Region: Cupin_2; cl17218 394503010444 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 394503010445 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 394503010446 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 394503010447 HIGH motif; other site 394503010448 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 394503010449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 394503010450 active site 394503010451 KMSKS motif; other site 394503010452 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 394503010453 tRNA binding surface [nucleotide binding]; other site 394503010454 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 394503010455 Accessory gene regulator B; Region: AgrB; pfam04647 394503010456 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 394503010457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 394503010458 ATP binding site [chemical binding]; other site 394503010459 Mg2+ binding site [ion binding]; other site 394503010460 G-X-G motif; other site 394503010461 SWIM zinc finger; Region: SWIM; pfam04434 394503010462 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 394503010463 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 394503010464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 394503010465 ATP binding site [chemical binding]; other site 394503010466 putative Mg++ binding site [ion binding]; other site 394503010467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 394503010468 nucleotide binding region [chemical binding]; other site 394503010469 ATP-binding site [chemical binding]; other site 394503010470 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 394503010471 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 394503010472 oligoendopeptidase F; Region: pepF; TIGR00181 394503010473 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 394503010474 active site 394503010475 Zn binding site [ion binding]; other site 394503010476 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 394503010477 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 394503010478 Ca binding site [ion binding]; other site 394503010479 carbohydrate binding site [chemical binding]; other site 394503010480 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 394503010481 Putative esterase; Region: Esterase; pfam00756 394503010482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503010483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 394503010484 DNA binding site [nucleotide binding] 394503010485 domain linker motif; other site 394503010486 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 394503010487 putative dimerization interface [polypeptide binding]; other site 394503010488 putative ligand binding site [chemical binding]; other site 394503010489 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 394503010490 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 394503010491 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 394503010492 intersubunit interface [polypeptide binding]; other site 394503010493 active site 394503010494 Zn2+ binding site [ion binding]; other site 394503010495 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 394503010496 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 394503010497 putative N- and C-terminal domain interface [polypeptide binding]; other site 394503010498 putative active site [active] 394503010499 MgATP binding site [chemical binding]; other site 394503010500 catalytic site [active] 394503010501 metal binding site [ion binding]; metal-binding site 394503010502 putative carbohydrate binding site [chemical binding]; other site 394503010503 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 394503010504 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 394503010505 hexamer (dimer of trimers) interface [polypeptide binding]; other site 394503010506 substrate binding site [chemical binding]; other site 394503010507 trimer interface [polypeptide binding]; other site 394503010508 Mn binding site [ion binding]; other site 394503010509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 394503010510 DNA-binding site [nucleotide binding]; DNA binding site 394503010511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 394503010512 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 394503010513 putative dimerization interface [polypeptide binding]; other site 394503010514 putative ligand binding site [chemical binding]; other site 394503010515 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 394503010516 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 394503010517 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 394503010518 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 394503010519 non-heme iron binding site [ion binding]; other site 394503010520 dimer interface [polypeptide binding]; other site 394503010521 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 394503010522 non-heme iron binding site [ion binding]; other site 394503010523 putative lipid kinase; Reviewed; Region: PRK13059 394503010524 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 394503010525 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 394503010526 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 394503010527 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 394503010528 dimerization interface [polypeptide binding]; other site 394503010529 active site 394503010530 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 394503010531 L-aspartate oxidase; Provisional; Region: PRK06175 394503010532 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 394503010533 Quinolinate synthetase A protein; Region: NadA; pfam02445 394503010534 DNA gyrase subunit A; Validated; Region: PRK05560 394503010535 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 394503010536 CAP-like domain; other site 394503010537 active site 394503010538 primary dimer interface [polypeptide binding]; other site 394503010539 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010540 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010541 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010542 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010543 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 394503010545 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 394503010546 ParB-like nuclease domain; Region: ParBc; pfam02195 394503010547 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 394503010548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 394503010549 S-adenosylmethionine binding site [chemical binding]; other site 394503010550 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 394503010551 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 394503010552 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 394503010553 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 394503010554 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 394503010555 trmE is a tRNA modification GTPase; Region: trmE; cd04164 394503010556 G1 box; other site 394503010557 GTP/Mg2+ binding site [chemical binding]; other site 394503010558 Switch I region; other site 394503010559 G2 box; other site 394503010560 Switch II region; other site 394503010561 G3 box; other site 394503010562 G4 box; other site 394503010563 G5 box; other site 394503010564 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 394503010565 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 394503010566 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 394503010567 G-X-X-G motif; other site 394503010568 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 394503010569 RxxxH motif; other site 394503010570 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 394503010571 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 394503010572 Haemolytic domain; Region: Haemolytic; pfam01809 394503010573 ribonuclease P; Reviewed; Region: rnpA; PRK00499 394503010574 Ribosomal protein L34; Region: Ribosomal_L34; cl00370