-- dump date 20140619_043838 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573061000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 573061000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573061000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061000004 Walker A motif; other site 573061000005 ATP binding site [chemical binding]; other site 573061000006 Walker B motif; other site 573061000007 arginine finger; other site 573061000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573061000009 DnaA box-binding interface [nucleotide binding]; other site 573061000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 573061000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573061000012 putative DNA binding surface [nucleotide binding]; other site 573061000013 dimer interface [polypeptide binding]; other site 573061000014 beta-clamp/clamp loader binding surface; other site 573061000015 beta-clamp/translesion DNA polymerase binding surface; other site 573061000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061000017 RNA binding surface [nucleotide binding]; other site 573061000018 recombination protein F; Reviewed; Region: recF; PRK00064 573061000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 573061000020 Walker A/P-loop; other site 573061000021 ATP binding site [chemical binding]; other site 573061000022 Q-loop/lid; other site 573061000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061000024 ABC transporter signature motif; other site 573061000025 Walker B; other site 573061000026 D-loop; other site 573061000027 H-loop/switch region; other site 573061000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 573061000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000030 Mg2+ binding site [ion binding]; other site 573061000031 G-X-G motif; other site 573061000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573061000033 anchoring element; other site 573061000034 dimer interface [polypeptide binding]; other site 573061000035 ATP binding site [chemical binding]; other site 573061000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573061000037 active site 573061000038 putative metal-binding site [ion binding]; other site 573061000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573061000040 DNA gyrase subunit A; Validated; Region: PRK05560 573061000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573061000042 CAP-like domain; other site 573061000043 active site 573061000044 primary dimer interface [polypeptide binding]; other site 573061000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061000050 HD domain; Region: HD; pfam01966 573061000051 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 573061000052 HTH domain; Region: HTH_11; pfam08279 573061000053 3H domain; Region: 3H; pfam02829 573061000054 hypothetical protein; Validated; Region: PRK00068 573061000055 Uncharacterized conserved protein [Function unknown]; Region: COG1615 573061000056 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573061000057 FAD dependent oxidoreductase; Region: DAO; pfam01266 573061000058 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573061000059 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 573061000060 seryl-tRNA synthetase; Provisional; Region: PRK05431 573061000061 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573061000062 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573061000063 dimer interface [polypeptide binding]; other site 573061000064 active site 573061000065 motif 1; other site 573061000066 motif 2; other site 573061000067 motif 3; other site 573061000068 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061000069 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573061000070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061000071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061000072 dimer interface [polypeptide binding]; other site 573061000073 phosphorylation site [posttranslational modification] 573061000074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000075 ATP binding site [chemical binding]; other site 573061000076 Mg2+ binding site [ion binding]; other site 573061000077 G-X-G motif; other site 573061000078 Response regulator receiver domain; Region: Response_reg; pfam00072 573061000079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061000080 active site 573061000081 phosphorylation site [posttranslational modification] 573061000082 intermolecular recognition site; other site 573061000083 dimerization interface [polypeptide binding]; other site 573061000084 Histidine kinase; Region: His_kinase; pfam06580 573061000085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000086 ATP binding site [chemical binding]; other site 573061000087 Mg2+ binding site [ion binding]; other site 573061000088 G-X-G motif; other site 573061000089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000090 Coenzyme A binding pocket [chemical binding]; other site 573061000091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061000092 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 573061000093 Phage Tail Collar Domain; Region: Collar; pfam07484 573061000094 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 573061000095 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061000096 Interdomain contacts; other site 573061000097 Cytokine receptor motif; other site 573061000098 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 573061000099 Protein of unknown function, DUF624; Region: DUF624; cl02369 573061000100 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061000101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061000102 dimer interface [polypeptide binding]; other site 573061000103 putative CheW interface [polypeptide binding]; other site 573061000104 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061000105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061000106 dimer interface [polypeptide binding]; other site 573061000107 putative CheW interface [polypeptide binding]; other site 573061000108 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061000109 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061000110 dimer interface [polypeptide binding]; other site 573061000111 putative CheW interface [polypeptide binding]; other site 573061000112 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 573061000113 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573061000114 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573061000115 PhoU domain; Region: PhoU; pfam01895 573061000116 PhoU domain; Region: PhoU; pfam01895 573061000117 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573061000118 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000121 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 573061000122 substrate binding site [chemical binding]; other site 573061000123 active site 573061000124 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 573061000125 metal binding site [ion binding]; metal-binding site 573061000126 ligand binding site [chemical binding]; other site 573061000127 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573061000128 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573061000129 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573061000130 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 573061000131 metal binding site [ion binding]; metal-binding site 573061000132 ligand binding site [chemical binding]; other site 573061000133 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 573061000134 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 573061000135 catalytic domain interface [polypeptide binding]; other site 573061000136 homodimer interface [polypeptide binding]; other site 573061000137 putative active site [active] 573061000138 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 573061000139 active site 573061000140 putative alpha-glucosidase; Provisional; Region: PRK10658 573061000141 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573061000142 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 573061000143 active site 573061000144 homotrimer interface [polypeptide binding]; other site 573061000145 catalytic site [active] 573061000146 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 573061000147 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573061000148 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573061000149 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573061000150 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061000151 Histidine kinase; Region: His_kinase; pfam06580 573061000152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000153 ATP binding site [chemical binding]; other site 573061000154 Mg2+ binding site [ion binding]; other site 573061000155 G-X-G motif; other site 573061000156 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 573061000157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061000158 active site 573061000159 phosphorylation site [posttranslational modification] 573061000160 intermolecular recognition site; other site 573061000161 dimerization interface [polypeptide binding]; other site 573061000162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061000164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061000165 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573061000166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061000167 dimer interface [polypeptide binding]; other site 573061000168 conserved gate region; other site 573061000169 ABC-ATPase subunit interface; other site 573061000170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061000171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061000172 dimer interface [polypeptide binding]; other site 573061000173 conserved gate region; other site 573061000174 ABC-ATPase subunit interface; other site 573061000175 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573061000176 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573061000177 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573061000178 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 573061000179 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 573061000180 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 573061000181 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573061000182 nucleoside/Zn binding site; other site 573061000183 dimer interface [polypeptide binding]; other site 573061000184 catalytic motif [active] 573061000185 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573061000186 Rhomboid family; Region: Rhomboid; pfam01694 573061000187 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 573061000188 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 573061000189 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 573061000190 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573061000191 intersubunit interface [polypeptide binding]; other site 573061000192 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 573061000193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061000194 Walker A motif; other site 573061000195 ATP binding site [chemical binding]; other site 573061000196 Walker B motif; other site 573061000197 arginine finger; other site 573061000198 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573061000199 hypothetical protein; Validated; Region: PRK00153 573061000200 recombination protein RecR; Reviewed; Region: recR; PRK00076 573061000201 RecR protein; Region: RecR; pfam02132 573061000202 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573061000203 putative active site [active] 573061000204 putative metal-binding site [ion binding]; other site 573061000205 tetramer interface [polypeptide binding]; other site 573061000206 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 573061000207 Predicted transcriptional regulators [Transcription]; Region: COG1725 573061000208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061000209 DNA-binding site [nucleotide binding]; DNA binding site 573061000210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061000211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061000212 Walker A/P-loop; other site 573061000213 ATP binding site [chemical binding]; other site 573061000214 Q-loop/lid; other site 573061000215 ABC transporter signature motif; other site 573061000216 Walker B; other site 573061000217 D-loop; other site 573061000218 H-loop/switch region; other site 573061000219 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061000220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061000221 Walker A/P-loop; other site 573061000222 ATP binding site [chemical binding]; other site 573061000223 Q-loop/lid; other site 573061000224 ABC transporter signature motif; other site 573061000225 Walker B; other site 573061000226 D-loop; other site 573061000227 H-loop/switch region; other site 573061000228 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 573061000229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061000230 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061000231 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 573061000232 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 573061000233 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 573061000234 active site 573061000235 Zn binding site [ion binding]; other site 573061000236 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061000237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061000238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061000239 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061000240 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 573061000241 putative active site [active] 573061000242 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 573061000243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061000244 Zn2+ binding site [ion binding]; other site 573061000245 Mg2+ binding site [ion binding]; other site 573061000246 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061000247 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573061000248 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 573061000249 oligomer interface [polypeptide binding]; other site 573061000250 active site 573061000251 metal binding site [ion binding]; metal-binding site 573061000252 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573061000253 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 573061000254 oligomer interface [polypeptide binding]; other site 573061000255 active site 573061000256 metal binding site [ion binding]; metal-binding site 573061000257 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573061000258 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573061000259 metal binding site [ion binding]; metal-binding site 573061000260 Predicted integral membrane protein [Function unknown]; Region: COG5652 573061000261 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573061000262 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573061000263 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573061000264 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 573061000265 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 573061000266 putative substrate binding site [chemical binding]; other site 573061000267 putative ATP binding site [chemical binding]; other site 573061000268 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 573061000269 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573061000270 active site 573061000271 phosphorylation site [posttranslational modification] 573061000272 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 573061000273 active site 573061000274 P-loop; other site 573061000275 phosphorylation site [posttranslational modification] 573061000276 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 573061000277 stage V sporulation protein B; Region: spore_V_B; TIGR02900 573061000278 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 573061000279 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573061000280 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573061000281 Tetramer interface [polypeptide binding]; other site 573061000282 active site 573061000283 FMN-binding site [chemical binding]; other site 573061000284 Dehydroquinase class II; Region: DHquinase_II; pfam01220 573061000285 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 573061000286 trimer interface [polypeptide binding]; other site 573061000287 active site 573061000288 dimer interface [polypeptide binding]; other site 573061000289 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 573061000290 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573061000291 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 573061000292 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 573061000293 [2Fe-2S] cluster binding site [ion binding]; other site 573061000294 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573061000295 PRTRC system protein D; Region: PRTRC_D; TIGR03739 573061000296 Mg binding site [ion binding]; other site 573061000297 nucleotide binding site [chemical binding]; other site 573061000298 putative protofilament interface [polypeptide binding]; other site 573061000299 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 573061000300 AAA ATPase domain; Region: AAA_16; pfam13191 573061000301 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 573061000302 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573061000303 metal ion-dependent adhesion site (MIDAS); other site 573061000304 SpoVR like protein; Region: SpoVR; pfam04293 573061000305 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 573061000306 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573061000307 active site 573061000308 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 573061000309 dimer interface [polypeptide binding]; other site 573061000310 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573061000311 Ligand Binding Site [chemical binding]; other site 573061000312 Molecular Tunnel; other site 573061000313 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061000314 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573061000315 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 573061000316 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573061000317 FAD binding site [chemical binding]; other site 573061000318 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573061000319 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573061000320 nucleotide binding site [chemical binding]; other site 573061000321 substrate binding site [chemical binding]; other site 573061000322 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 573061000323 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 573061000324 dimer interface [polypeptide binding]; other site 573061000325 catalytic triad [active] 573061000326 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 573061000327 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 573061000328 Cl binding site [ion binding]; other site 573061000329 oligomer interface [polypeptide binding]; other site 573061000330 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573061000331 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573061000332 metal binding site [ion binding]; metal-binding site 573061000333 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 573061000334 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 573061000335 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573061000336 homodimer interface [polypeptide binding]; other site 573061000337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061000338 catalytic residue [active] 573061000339 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573061000340 thymidylate kinase; Validated; Region: tmk; PRK00698 573061000341 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573061000342 TMP-binding site; other site 573061000343 ATP-binding site [chemical binding]; other site 573061000344 Protein of unknown function (DUF970); Region: DUF970; cl17525 573061000345 DNA polymerase III subunit delta'; Validated; Region: PRK05564 573061000346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061000347 Walker A motif; other site 573061000348 ATP binding site [chemical binding]; other site 573061000349 Walker B motif; other site 573061000350 arginine finger; other site 573061000351 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 573061000352 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 573061000353 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061000354 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573061000355 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 573061000356 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 573061000357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000358 S-adenosylmethionine binding site [chemical binding]; other site 573061000359 Predicted methyltransferases [General function prediction only]; Region: COG0313 573061000360 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573061000361 putative SAM binding site [chemical binding]; other site 573061000362 putative homodimer interface [polypeptide binding]; other site 573061000363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 573061000364 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573061000365 NlpC/P60 family; Region: NLPC_P60; pfam00877 573061000366 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 573061000367 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 573061000368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061000369 dimerization interface [polypeptide binding]; other site 573061000370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061000371 dimer interface [polypeptide binding]; other site 573061000372 phosphorylation site [posttranslational modification] 573061000373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000374 ATP binding site [chemical binding]; other site 573061000375 Mg2+ binding site [ion binding]; other site 573061000376 G-X-G motif; other site 573061000377 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573061000378 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573061000379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573061000380 protein binding site [polypeptide binding]; other site 573061000381 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573061000382 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573061000383 ABC-ATPase subunit interface; other site 573061000384 dimer interface [polypeptide binding]; other site 573061000385 putative PBP binding regions; other site 573061000386 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573061000387 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573061000388 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 573061000389 metal binding triad [ion binding]; metal-binding site 573061000390 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 573061000391 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 573061000392 YvrJ protein family; Region: YvrJ; pfam12841 573061000393 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 573061000394 VanW like protein; Region: VanW; pfam04294 573061000395 G5 domain; Region: G5; pfam07501 573061000396 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 573061000397 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573061000398 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 573061000399 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573061000400 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573061000401 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 573061000402 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573061000403 ligand binding site [chemical binding]; other site 573061000404 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 573061000405 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 573061000406 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573061000407 homotrimer interaction site [polypeptide binding]; other site 573061000408 zinc binding site [ion binding]; other site 573061000409 CDP-binding sites; other site 573061000410 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 573061000411 active site 573061000412 catalytic site [active] 573061000413 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 573061000414 Predicted membrane protein [Function unknown]; Region: COG4684 573061000415 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 573061000416 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 573061000417 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 573061000418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061000419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061000420 non-specific DNA binding site [nucleotide binding]; other site 573061000421 salt bridge; other site 573061000422 sequence-specific DNA binding site [nucleotide binding]; other site 573061000423 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 573061000424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061000425 active site 573061000426 motif I; other site 573061000427 motif II; other site 573061000428 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 573061000429 Family description; Region: VCBS; pfam13517 573061000430 Family description; Region: VCBS; pfam13517 573061000431 Family description; Region: VCBS; pfam13517 573061000432 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573061000433 NlpC/P60 family; Region: NLPC_P60; pfam00877 573061000434 Family description; Region: VCBS; pfam13517 573061000435 Family description; Region: VCBS; pfam13517 573061000436 Family description; Region: VCBS; pfam13517 573061000437 Lysozyme family protein [General function prediction only]; Region: COG5526 573061000438 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061000439 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 573061000440 putative active site [active] 573061000441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061000442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061000443 Walker A/P-loop; other site 573061000444 ATP binding site [chemical binding]; other site 573061000445 Q-loop/lid; other site 573061000446 ABC transporter signature motif; other site 573061000447 Walker B; other site 573061000448 D-loop; other site 573061000449 H-loop/switch region; other site 573061000450 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573061000451 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573061000452 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061000453 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000454 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000455 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061000456 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000457 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000458 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061000459 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000460 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573061000461 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061000462 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061000463 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061000464 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061000465 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061000466 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061000467 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061000468 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061000469 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061000470 Cysteine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4870 573061000471 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 573061000472 active site 573061000473 Bacterial Ig-like domain; Region: Big_5; pfam13205 573061000474 Bacterial Ig-like domain; Region: Big_5; pfam13205 573061000475 Bacterial Ig-like domain; Region: Big_5; pfam13205 573061000476 Bacterial Ig-like domain; Region: Big_5; pfam13205 573061000477 Bacterial Ig-like domain; Region: Big_5; pfam13205 573061000478 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061000479 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573061000480 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061000481 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061000482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061000483 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573061000484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061000485 motif II; other site 573061000486 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573061000487 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 573061000488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061000489 active site 573061000490 metal binding site [ion binding]; metal-binding site 573061000491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061000492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000493 Coenzyme A binding pocket [chemical binding]; other site 573061000494 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000496 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000498 S-adenosylmethionine binding site [chemical binding]; other site 573061000499 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573061000500 nucleoside/Zn binding site; other site 573061000501 dimer interface [polypeptide binding]; other site 573061000502 catalytic motif [active] 573061000503 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061000504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000505 Coenzyme A binding pocket [chemical binding]; other site 573061000506 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 573061000507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061000508 binding surface 573061000509 TPR motif; other site 573061000510 TPR repeat; Region: TPR_11; pfam13414 573061000511 TPR repeat; Region: TPR_11; pfam13414 573061000512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061000513 binding surface 573061000514 TPR motif; other site 573061000515 TPR repeat; Region: TPR_11; pfam13414 573061000516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061000517 binding surface 573061000518 TPR motif; other site 573061000519 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061000520 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 573061000521 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061000522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061000523 non-specific DNA binding site [nucleotide binding]; other site 573061000524 salt bridge; other site 573061000525 sequence-specific DNA binding site [nucleotide binding]; other site 573061000526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061000527 non-specific DNA binding site [nucleotide binding]; other site 573061000528 salt bridge; other site 573061000529 sequence-specific DNA binding site [nucleotide binding]; other site 573061000530 CHC2 zinc finger; Region: zf-CHC2; cl17510 573061000531 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 573061000532 active site 573061000533 catalytic triad [active] 573061000534 oxyanion hole [active] 573061000535 prolyl-tRNA synthetase; Provisional; Region: PRK08661 573061000536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061000539 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061000540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061000541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061000542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573061000543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573061000544 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061000545 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061000546 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 573061000547 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 573061000548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 573061000549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061000550 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573061000551 FeS/SAM binding site; other site 573061000552 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 573061000553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000555 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 573061000556 Predicted transcriptional regulators [Transcription]; Region: COG1733 573061000557 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573061000558 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061000559 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061000560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000561 S-adenosylmethionine binding site [chemical binding]; other site 573061000562 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573061000563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061000564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061000565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061000566 dimerization interface [polypeptide binding]; other site 573061000567 putative acyltransferase; Provisional; Region: PRK05790 573061000568 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573061000569 dimer interface [polypeptide binding]; other site 573061000570 active site 573061000571 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061000572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061000573 Walker A/P-loop; other site 573061000574 ATP binding site [chemical binding]; other site 573061000575 Q-loop/lid; other site 573061000576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061000577 ABC transporter; Region: ABC_tran_2; pfam12848 573061000578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061000579 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061000580 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573061000581 DNA binding residues [nucleotide binding] 573061000582 dimer interface [polypeptide binding]; other site 573061000583 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 573061000584 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061000585 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573061000586 DNA binding residues [nucleotide binding] 573061000587 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573061000588 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061000589 DNA binding residues [nucleotide binding] 573061000590 dimer interface [polypeptide binding]; other site 573061000591 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573061000592 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061000593 Walker A/P-loop; other site 573061000594 ATP binding site [chemical binding]; other site 573061000595 Q-loop/lid; other site 573061000596 ABC transporter signature motif; other site 573061000597 Walker B; other site 573061000598 D-loop; other site 573061000599 H-loop/switch region; other site 573061000600 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573061000601 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573061000602 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061000603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061000604 dimer interface [polypeptide binding]; other site 573061000605 putative CheW interface [polypeptide binding]; other site 573061000606 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573061000607 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 573061000608 Mg++ binding site [ion binding]; other site 573061000609 Mor transcription activator family; Region: Mor; cl02360 573061000610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573061000611 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573061000612 H+ Antiporter protein; Region: 2A0121; TIGR00900 573061000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061000614 putative substrate translocation pore; other site 573061000615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000617 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573061000618 Pectinesterase; Region: Pectinesterase; pfam01095 573061000619 putative pectinesterase; Region: PLN02432; cl01911 573061000620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061000621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061000622 metal binding site [ion binding]; metal-binding site 573061000623 active site 573061000624 I-site; other site 573061000625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573061000626 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061000627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061000628 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 573061000629 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 573061000630 Mu-like prophage protein Com; Region: Mu-like_Com; cl11540 573061000631 Phage-related protein [Function unknown]; Region: COG5412 573061000632 Phage-related protein [Function unknown]; Region: COG4722 573061000633 Phage tail protein; Region: Sipho_tail; cl17486 573061000634 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 573061000635 Right handed beta helix region; Region: Beta_helix; pfam13229 573061000636 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 573061000637 Right handed beta helix region; Region: Beta_helix; pfam13229 573061000638 Holin family; Region: Phage_holin_4; pfam05105 573061000639 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 573061000640 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 573061000641 active site 573061000642 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 573061000643 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061000644 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573061000645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061000646 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573061000647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061000648 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573061000649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573061000650 ligand binding site [chemical binding]; other site 573061000651 flexible hinge region; other site 573061000652 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 573061000653 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 573061000654 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061000655 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573061000656 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061000657 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573061000658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061000659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061000660 DNA binding residues [nucleotide binding] 573061000661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573061000662 catalytic core [active] 573061000663 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000665 S-adenosylmethionine binding site [chemical binding]; other site 573061000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000667 S-adenosylmethionine binding site [chemical binding]; other site 573061000668 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573061000669 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573061000670 folate binding site [chemical binding]; other site 573061000671 NADP+ binding site [chemical binding]; other site 573061000672 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 573061000673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061000674 dimerization interface [polypeptide binding]; other site 573061000675 putative DNA binding site [nucleotide binding]; other site 573061000676 putative Zn2+ binding site [ion binding]; other site 573061000677 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573061000678 Low molecular weight phosphatase family; Region: LMWPc; cl00105 573061000679 active site 573061000680 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061000681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061000682 active site 573061000683 phosphorylation site [posttranslational modification] 573061000684 intermolecular recognition site; other site 573061000685 dimerization interface [polypeptide binding]; other site 573061000686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061000687 DNA binding site [nucleotide binding] 573061000688 HAMP domain; Region: HAMP; pfam00672 573061000689 PAS domain; Region: PAS_8; pfam13188 573061000690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061000691 dimer interface [polypeptide binding]; other site 573061000692 phosphorylation site [posttranslational modification] 573061000693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061000694 ATP binding site [chemical binding]; other site 573061000695 Mg2+ binding site [ion binding]; other site 573061000696 G-X-G motif; other site 573061000697 Predicted membrane protein [Function unknown]; Region: COG3462 573061000698 Short C-terminal domain; Region: SHOCT; pfam09851 573061000699 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061000700 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061000701 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 573061000702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061000703 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573061000704 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 573061000705 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 573061000706 dinuclear metal binding motif [ion binding]; other site 573061000707 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573061000708 active site 573061000709 ATP binding site [chemical binding]; other site 573061000710 substrate binding site [chemical binding]; other site 573061000711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 573061000712 activation loop (A-loop); other site 573061000713 activation loop (A-loop); other site 573061000714 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573061000715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061000716 putative substrate translocation pore; other site 573061000717 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573061000718 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573061000719 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573061000720 putative active site [active] 573061000721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 573061000722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061000723 putative metal binding site [ion binding]; other site 573061000724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061000725 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573061000726 active site 573061000727 motif I; other site 573061000728 motif II; other site 573061000729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 573061000730 motif II; other site 573061000731 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573061000732 active site residue [active] 573061000733 YbaK / prolyl-tRNA synthetases associated domain; Region: YbaK; pfam04073 573061000734 putative deacylase active site [active] 573061000735 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573061000736 nucleoside/Zn binding site; other site 573061000737 dimer interface [polypeptide binding]; other site 573061000738 catalytic motif [active] 573061000739 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 573061000740 putative NADH binding site [chemical binding]; other site 573061000741 putative active site [active] 573061000742 nudix motif; other site 573061000743 putative metal binding site [ion binding]; other site 573061000744 maltose O-acetyltransferase; Provisional; Region: PRK10092 573061000745 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 573061000746 active site 573061000747 substrate binding site [chemical binding]; other site 573061000748 trimer interface [polypeptide binding]; other site 573061000749 CoA binding site [chemical binding]; other site 573061000750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000751 Coenzyme A binding pocket [chemical binding]; other site 573061000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000753 S-adenosylmethionine binding site [chemical binding]; other site 573061000754 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 573061000755 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 573061000756 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573061000757 HIGH motif; other site 573061000758 active site 573061000759 KMSKS motif; other site 573061000760 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573061000761 tRNA binding surface [nucleotide binding]; other site 573061000762 anticodon binding site; other site 573061000763 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 573061000764 dimer interface [polypeptide binding]; other site 573061000765 putative tRNA-binding site [nucleotide binding]; other site 573061000766 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 573061000767 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 573061000768 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061000769 Predicted acetyltransferase [General function prediction only]; Region: COG3981 573061000770 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061000771 Coenzyme A binding pocket [chemical binding]; other site 573061000772 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 573061000773 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061000774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000775 S-adenosylmethionine binding site [chemical binding]; other site 573061000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 573061000777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061000778 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061000779 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 573061000780 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573061000781 tetramer interface [polypeptide binding]; other site 573061000782 active site 573061000783 Mg2+/Mn2+ binding site [ion binding]; other site 573061000784 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061000785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000786 Coenzyme A binding pocket [chemical binding]; other site 573061000787 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 573061000788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061000789 motif II; other site 573061000790 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573061000791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061000792 motif II; other site 573061000793 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 573061000794 nudix motif; other site 573061000795 Predicted membrane protein [General function prediction only]; Region: COG4194 573061000796 Predicted transcriptional regulators [Transcription]; Region: COG1725 573061000797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061000798 DNA-binding site [nucleotide binding]; DNA binding site 573061000799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000801 S-adenosylmethionine binding site [chemical binding]; other site 573061000802 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061000803 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061000804 ligand binding site [chemical binding]; other site 573061000805 calcium binding site [ion binding]; other site 573061000806 Cupin domain; Region: Cupin_2; pfam07883 573061000807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061000808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061000809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573061000810 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573061000811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061000812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061000813 Coenzyme A binding pocket [chemical binding]; other site 573061000814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061000815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061000816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061000817 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061000818 Walker A/P-loop; other site 573061000819 ATP binding site [chemical binding]; other site 573061000820 Q-loop/lid; other site 573061000821 ABC transporter signature motif; other site 573061000822 Walker B; other site 573061000823 D-loop; other site 573061000824 H-loop/switch region; other site 573061000825 FtsX-like permease family; Region: FtsX; pfam02687 573061000826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061000827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061000828 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573061000829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061000830 Walker A/P-loop; other site 573061000831 ATP binding site [chemical binding]; other site 573061000832 Q-loop/lid; other site 573061000833 ABC transporter signature motif; other site 573061000834 Walker B; other site 573061000835 D-loop; other site 573061000836 H-loop/switch region; other site 573061000837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573061000838 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573061000839 YcxB-like protein; Region: YcxB; pfam14317 573061000840 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 573061000841 active site 573061000842 catalytic residues [active] 573061000843 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061000844 Kelch motif; Region: Kelch_1; pfam01344 573061000845 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000846 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000847 Kelch motif; Region: Kelch_1; pfam01344 573061000848 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000849 Kelch motif; Region: Kelch_1; pfam01344 573061000850 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000851 Kelch domain; Region: Kelch; smart00612 573061000852 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000853 Kelch domain; Region: Kelch; smart00612 573061000854 Kelch motif; Region: Kelch_1; pfam01344 573061000855 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061000856 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 573061000857 Kelch domain; Region: Kelch; smart00612 573061000858 Kelch domain; Region: Kelch; smart00612 573061000859 Kelch motif; Region: Kelch_1; pfam01344 573061000860 Kelch motif; Region: Kelch_1; pfam01344 573061000861 Kelch motif; Region: Kelch_1; pfam01344 573061000862 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061000863 Kelch domain; Region: Kelch; smart00612 573061000864 Kelch motif; Region: Kelch_1; pfam01344 573061000865 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061000866 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061000867 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061000868 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061000869 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061000870 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061000871 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061000872 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 573061000873 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573061000874 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 573061000875 putative Cl- selectivity filter; other site 573061000876 putative pore gating glutamate residue; other site 573061000877 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 573061000878 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061000879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061000880 dimerization interface [polypeptide binding]; other site 573061000881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061000882 dimer interface [polypeptide binding]; other site 573061000883 putative CheW interface [polypeptide binding]; other site 573061000884 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 573061000885 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573061000886 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 573061000887 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 573061000888 Protein of unknown function (DUF445); Region: DUF445; pfam04286 573061000889 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573061000890 DNA-binding site [nucleotide binding]; DNA binding site 573061000891 RNA-binding motif; other site 573061000892 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573061000893 active site 573061000894 Domain of unknown function (DUF348); Region: DUF348; pfam03990 573061000895 G5 domain; Region: G5; pfam07501 573061000896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 573061000897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 573061000898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 573061000899 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 573061000900 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 573061000901 putative active site [active] 573061000902 putative metal binding site [ion binding]; other site 573061000903 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 573061000904 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573061000905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061000906 S-adenosylmethionine binding site [chemical binding]; other site 573061000907 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573061000908 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 573061000909 shikimate kinase; Reviewed; Region: aroK; PRK00131 573061000910 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573061000911 ADP binding site [chemical binding]; other site 573061000912 magnesium binding site [ion binding]; other site 573061000913 putative shikimate binding site; other site 573061000914 Chorismate mutase type II; Region: CM_2; smart00830 573061000915 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 573061000916 Prephenate dehydratase; Region: PDT; pfam00800 573061000917 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573061000918 putative L-Phe binding site [chemical binding]; other site 573061000919 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573061000920 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573061000921 Tetramer interface [polypeptide binding]; other site 573061000922 active site 573061000923 FMN-binding site [chemical binding]; other site 573061000924 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573061000925 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573061000926 hinge; other site 573061000927 active site 573061000928 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 573061000929 prephenate dehydrogenase; Validated; Region: PRK08507 573061000930 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 573061000931 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 573061000932 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061000933 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061000934 EDD domain protein, DegV family; Region: DegV; TIGR00762 573061000935 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 573061000936 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573061000937 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 573061000938 active site 573061000939 Substrate binding site; other site 573061000940 Mg++ binding site; other site 573061000941 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573061000942 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573061000943 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 573061000944 active site 573061000945 substrate binding site [chemical binding]; other site 573061000946 metal binding site [ion binding]; metal-binding site 573061000947 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 573061000948 ATP cone domain; Region: ATP-cone; pfam03477 573061000949 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573061000950 effector binding site; other site 573061000951 active site 573061000952 Zn binding site [ion binding]; other site 573061000953 glycine loop; other site 573061000954 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 573061000955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061000956 FeS/SAM binding site; other site 573061000957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061000958 dimerization interface [polypeptide binding]; other site 573061000959 putative DNA binding site [nucleotide binding]; other site 573061000960 putative Zn2+ binding site [ion binding]; other site 573061000961 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573061000962 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 573061000963 CAAX protease self-immunity; Region: Abi; pfam02517 573061000964 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 573061000965 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573061000966 HIGH motif; other site 573061000967 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573061000968 active site 573061000969 KMSKS motif; other site 573061000970 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 573061000971 tRNA binding surface [nucleotide binding]; other site 573061000972 anticodon binding site; other site 573061000973 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 573061000974 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 573061000975 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 573061000976 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573061000977 Ligand binding site; other site 573061000978 Putative Catalytic site; other site 573061000979 DXD motif; other site 573061000980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061000981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061000982 DNA binding site [nucleotide binding] 573061000983 domain linker motif; other site 573061000984 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061000985 AAA domain; Region: AAA_11; pfam13086 573061000986 Part of AAA domain; Region: AAA_19; pfam13245 573061000987 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 573061000988 AAA domain; Region: AAA_12; pfam13087 573061000989 Protein of unknown function DUF45; Region: DUF45; pfam01863 573061000990 excinuclease ABC subunit B; Provisional; Region: PRK05298 573061000991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061000992 ATP binding site [chemical binding]; other site 573061000993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061000994 nucleotide binding region [chemical binding]; other site 573061000995 ATP-binding site [chemical binding]; other site 573061000996 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573061000997 UvrB/uvrC motif; Region: UVR; pfam02151 573061000998 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573061000999 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573061001000 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573061001001 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573061001002 RHS Repeat; Region: RHS_repeat; cl11982 573061001003 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061001004 Interdomain contacts; other site 573061001005 Cytokine receptor motif; other site 573061001006 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061001007 Interdomain contacts; other site 573061001008 Cytokine receptor motif; other site 573061001009 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061001010 Interdomain contacts; other site 573061001011 Cytokine receptor motif; other site 573061001012 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 573061001013 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 573061001014 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573061001015 NMT1-like family; Region: NMT1_2; pfam13379 573061001016 substrate binding pocket [chemical binding]; other site 573061001017 membrane-bound complex binding site; other site 573061001018 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573061001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573061001020 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573061001021 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573061001022 Walker A/P-loop; other site 573061001023 ATP binding site [chemical binding]; other site 573061001024 Q-loop/lid; other site 573061001025 ABC transporter signature motif; other site 573061001026 Walker B; other site 573061001027 D-loop; other site 573061001028 H-loop/switch region; other site 573061001029 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061001030 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 573061001031 ACS interaction site; other site 573061001032 CODH interaction site; other site 573061001033 metal cluster binding site [ion binding]; other site 573061001034 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 573061001035 active site clefts [active] 573061001036 zinc binding site [ion binding]; other site 573061001037 dimer interface [polypeptide binding]; other site 573061001038 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 573061001039 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573061001040 glutamine binding [chemical binding]; other site 573061001041 catalytic triad [active] 573061001042 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 573061001043 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573061001044 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573061001045 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573061001046 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 573061001047 homodimer interface [polypeptide binding]; other site 573061001048 substrate-cofactor binding pocket; other site 573061001049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061001050 catalytic residue [active] 573061001051 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 573061001052 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573061001053 phosphopeptide binding site; other site 573061001054 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 573061001055 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573061001056 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 573061001057 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573061001058 GIY-YIG motif/motif A; other site 573061001059 active site 573061001060 catalytic site [active] 573061001061 putative DNA binding site [nucleotide binding]; other site 573061001062 metal binding site [ion binding]; metal-binding site 573061001063 UvrB/uvrC motif; Region: UVR; pfam02151 573061001064 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573061001065 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 573061001066 putative hydrolase; Validated; Region: PRK09248 573061001067 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 573061001068 active site 573061001069 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 573061001070 FAD binding domain; Region: FAD_binding_4; pfam01565 573061001071 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573061001072 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 573061001073 AAA domain; Region: AAA_33; pfam13671 573061001074 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 573061001075 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 573061001076 phosphate binding site [ion binding]; other site 573061001077 putative substrate binding pocket [chemical binding]; other site 573061001078 dimer interface [polypeptide binding]; other site 573061001079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 573061001080 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 573061001081 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061001082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061001083 DNA binding site [nucleotide binding] 573061001084 domain linker motif; other site 573061001085 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573061001086 dimerization interface [polypeptide binding]; other site 573061001087 ligand binding site [chemical binding]; other site 573061001088 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573061001089 Rubredoxin; Region: Rubredoxin; pfam00301 573061001090 iron binding site [ion binding]; other site 573061001091 Rubrerythrin [Energy production and conversion]; Region: COG1592 573061001092 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 573061001093 diiron binding motif [ion binding]; other site 573061001094 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573061001095 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061001096 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 573061001097 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573061001098 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573061001099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061001100 Coenzyme A binding pocket [chemical binding]; other site 573061001101 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 573061001102 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 573061001103 active site 573061001104 PHP Thumb interface [polypeptide binding]; other site 573061001105 metal binding site [ion binding]; metal-binding site 573061001106 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573061001107 generic binding surface II; other site 573061001108 generic binding surface I; other site 573061001109 6-phosphofructokinase; Provisional; Region: PRK03202 573061001110 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 573061001111 active site 573061001112 ADP/pyrophosphate binding site [chemical binding]; other site 573061001113 dimerization interface [polypeptide binding]; other site 573061001114 allosteric effector site; other site 573061001115 fructose-1,6-bisphosphate binding site; other site 573061001116 pyruvate kinase; Provisional; Region: PRK06354 573061001117 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 573061001118 domain interfaces; other site 573061001119 active site 573061001120 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 573061001121 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 573061001122 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 573061001123 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 573061001124 catalytic domain interface [polypeptide binding]; other site 573061001125 putative homodimer interface [polypeptide binding]; other site 573061001126 Protein of unknown function, DUF608; Region: DUF608; pfam04685 573061001127 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573061001128 Class II fumarases; Region: Fumarase_classII; cd01362 573061001129 active site 573061001130 tetramer interface [polypeptide binding]; other site 573061001131 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 573061001132 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573061001133 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 573061001134 putative NAD(P) binding site [chemical binding]; other site 573061001135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061001136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061001137 Coenzyme A binding pocket [chemical binding]; other site 573061001138 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 573061001139 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573061001140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573061001141 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 573061001142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061001143 NAD(P) binding site [chemical binding]; other site 573061001144 active site 573061001145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061001146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061001147 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573061001148 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 573061001149 active site 573061001150 FMN binding site [chemical binding]; other site 573061001151 substrate binding site [chemical binding]; other site 573061001152 putative catalytic residue [active] 573061001153 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 573061001154 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 573061001155 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 573061001156 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061001157 CAAX protease self-immunity; Region: Abi; pfam02517 573061001158 Helix-turn-helix domain; Region: HTH_18; pfam12833 573061001159 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061001160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061001161 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061001162 substrate binding site [chemical binding]; other site 573061001163 active site 573061001164 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061001165 FMN binding site [chemical binding]; other site 573061001166 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 573061001167 dimanganese center [ion binding]; other site 573061001168 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573061001169 conserved cys residue [active] 573061001170 Chorismate mutase type II; Region: CM_2; cl00693 573061001171 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573061001172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061001174 active site 573061001175 phosphorylation site [posttranslational modification] 573061001176 intermolecular recognition site; other site 573061001177 dimerization interface [polypeptide binding]; other site 573061001178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061001179 DNA binding site [nucleotide binding] 573061001180 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061001181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061001182 Walker A/P-loop; other site 573061001183 ATP binding site [chemical binding]; other site 573061001184 Q-loop/lid; other site 573061001185 ABC transporter signature motif; other site 573061001186 Walker B; other site 573061001187 D-loop; other site 573061001188 H-loop/switch region; other site 573061001189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061001190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061001191 dimer interface [polypeptide binding]; other site 573061001192 phosphorylation site [posttranslational modification] 573061001193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061001194 G-X-G motif; other site 573061001195 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 573061001196 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 573061001197 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 573061001198 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 573061001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061001200 Walker A/P-loop; other site 573061001201 ATP binding site [chemical binding]; other site 573061001202 Q-loop/lid; other site 573061001203 ABC transporter signature motif; other site 573061001204 Walker B; other site 573061001205 D-loop; other site 573061001206 H-loop/switch region; other site 573061001207 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 573061001208 L-asparaginase II; Region: Asparaginase_II; pfam06089 573061001209 L-asparaginase II; Region: Asparaginase_II; pfam06089 573061001210 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 573061001211 putative deacylase active site [active] 573061001212 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 573061001213 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061001214 active site 573061001215 metal binding site [ion binding]; metal-binding site 573061001216 homotetramer interface [polypeptide binding]; other site 573061001217 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 573061001218 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 573061001219 putative ATP binding site [chemical binding]; other site 573061001220 putative substrate interface [chemical binding]; other site 573061001221 Uncharacterized conserved protein [Function unknown]; Region: COG0397 573061001222 hypothetical protein; Validated; Region: PRK00029 573061001223 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573061001224 NlpC/P60 family; Region: NLPC_P60; pfam00877 573061001225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061001226 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061001227 Walker A/P-loop; other site 573061001228 ATP binding site [chemical binding]; other site 573061001229 Q-loop/lid; other site 573061001230 ABC transporter signature motif; other site 573061001231 Walker B; other site 573061001232 D-loop; other site 573061001233 H-loop/switch region; other site 573061001234 Putative zinc-finger; Region: zf-HC2; pfam13490 573061001235 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 573061001236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061001237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061001238 DNA binding residues [nucleotide binding] 573061001239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061001240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061001241 substrate binding pocket [chemical binding]; other site 573061001242 membrane-bound complex binding site; other site 573061001243 hinge residues; other site 573061001244 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573061001245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061001246 dimer interface [polypeptide binding]; other site 573061001247 conserved gate region; other site 573061001248 putative PBP binding loops; other site 573061001249 ABC-ATPase subunit interface; other site 573061001250 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573061001251 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573061001252 Walker A/P-loop; other site 573061001253 ATP binding site [chemical binding]; other site 573061001254 Q-loop/lid; other site 573061001255 ABC transporter signature motif; other site 573061001256 Walker B; other site 573061001257 D-loop; other site 573061001258 H-loop/switch region; other site 573061001259 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 573061001260 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 573061001261 potential catalytic triad [active] 573061001262 conserved cys residue [active] 573061001263 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 573061001264 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573061001265 PYR/PP interface [polypeptide binding]; other site 573061001266 dimer interface [polypeptide binding]; other site 573061001267 TPP binding site [chemical binding]; other site 573061001268 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573061001269 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 573061001270 TPP-binding site [chemical binding]; other site 573061001271 dimer interface [polypeptide binding]; other site 573061001272 SnoaL-like domain; Region: SnoaL_2; pfam12680 573061001273 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 573061001274 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573061001275 conserved cys residue [active] 573061001276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061001277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061001278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573061001279 active site 573061001280 metal binding site [ion binding]; metal-binding site 573061001281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061001282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061001283 active site 573061001284 phosphorylation site [posttranslational modification] 573061001285 intermolecular recognition site; other site 573061001286 dimerization interface [polypeptide binding]; other site 573061001287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061001288 DNA binding site [nucleotide binding] 573061001289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001290 dimerization interface [polypeptide binding]; other site 573061001291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061001292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061001293 dimer interface [polypeptide binding]; other site 573061001294 phosphorylation site [posttranslational modification] 573061001295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061001296 ATP binding site [chemical binding]; other site 573061001297 Mg2+ binding site [ion binding]; other site 573061001298 G-X-G motif; other site 573061001299 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 573061001300 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 573061001301 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 573061001302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061001303 binding surface 573061001304 TPR motif; other site 573061001305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061001306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061001307 DNA binding residues [nucleotide binding] 573061001308 dimerization interface [polypeptide binding]; other site 573061001309 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573061001310 nudix motif; other site 573061001311 hypothetical protein; Provisional; Region: PRK06194 573061001312 classical (c) SDRs; Region: SDR_c; cd05233 573061001313 NAD(P) binding site [chemical binding]; other site 573061001314 active site 573061001315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061001316 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 573061001317 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 573061001318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061001319 Walker A/P-loop; other site 573061001320 ATP binding site [chemical binding]; other site 573061001321 Q-loop/lid; other site 573061001322 ABC transporter signature motif; other site 573061001323 Walker B; other site 573061001324 D-loop; other site 573061001325 H-loop/switch region; other site 573061001326 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 573061001327 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 573061001328 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 573061001329 Penicillinase repressor; Region: Pencillinase_R; pfam03965 573061001330 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 573061001331 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061001332 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061001333 putative transposase OrfB; Reviewed; Region: PHA02517 573061001334 HTH-like domain; Region: HTH_21; pfam13276 573061001335 Integrase core domain; Region: rve; pfam00665 573061001336 Integrase core domain; Region: rve_3; pfam13683 573061001337 Homeodomain-like domain; Region: HTH_23; cl17451 573061001338 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 573061001339 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573061001340 active site 573061001341 HIGH motif; other site 573061001342 dimer interface [polypeptide binding]; other site 573061001343 KMSKS motif; other site 573061001344 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061001345 RNA binding surface [nucleotide binding]; other site 573061001346 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061001347 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 573061001348 DNA binding residues [nucleotide binding] 573061001349 drug binding residues [chemical binding]; other site 573061001350 dimer interface [polypeptide binding]; other site 573061001351 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 573061001352 Phosphotransferase enzyme family; Region: APH; pfam01636 573061001353 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061001354 active site 573061001355 ATP binding site [chemical binding]; other site 573061001356 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061001357 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 573061001358 metal binding site [ion binding]; metal-binding site 573061001359 active site 573061001360 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061001361 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061001362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061001363 non-specific DNA binding site [nucleotide binding]; other site 573061001364 salt bridge; other site 573061001365 sequence-specific DNA binding site [nucleotide binding]; other site 573061001366 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 573061001367 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061001368 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061001369 Walker A/P-loop; other site 573061001370 ATP binding site [chemical binding]; other site 573061001371 Q-loop/lid; other site 573061001372 ABC transporter signature motif; other site 573061001373 Walker B; other site 573061001374 D-loop; other site 573061001375 H-loop/switch region; other site 573061001376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061001377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061001378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061001379 S-adenosylmethionine binding site [chemical binding]; other site 573061001380 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 573061001381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061001382 guanine deaminase; Region: guan_deamin; TIGR02967 573061001383 active site 573061001384 Cache domain; Region: Cache_1; pfam02743 573061001385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001386 dimerization interface [polypeptide binding]; other site 573061001387 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001388 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001389 dimer interface [polypeptide binding]; other site 573061001390 putative CheW interface [polypeptide binding]; other site 573061001391 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573061001392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061001393 S-adenosylmethionine binding site [chemical binding]; other site 573061001394 Mor transcription activator family; Region: Mor; cl02360 573061001395 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 573061001396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001397 dimerization interface [polypeptide binding]; other site 573061001398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001400 dimer interface [polypeptide binding]; other site 573061001401 putative CheW interface [polypeptide binding]; other site 573061001402 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001404 dimer interface [polypeptide binding]; other site 573061001405 putative CheW interface [polypeptide binding]; other site 573061001406 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 573061001407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573061001408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061001409 dimer interface [polypeptide binding]; other site 573061001410 phosphorylation site [posttranslational modification] 573061001411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061001412 ATP binding site [chemical binding]; other site 573061001413 Mg2+ binding site [ion binding]; other site 573061001414 G-X-G motif; other site 573061001415 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061001416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001417 dimerization interface [polypeptide binding]; other site 573061001418 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001419 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001420 dimer interface [polypeptide binding]; other site 573061001421 putative CheW interface [polypeptide binding]; other site 573061001422 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 573061001423 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061001424 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573061001425 NodB motif; other site 573061001426 active site 573061001427 catalytic site [active] 573061001428 metal binding site [ion binding]; metal-binding site 573061001429 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 573061001430 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 573061001431 biotin synthase; Region: bioB; TIGR00433 573061001432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061001433 FeS/SAM binding site; other site 573061001434 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 573061001435 AAA domain; Region: AAA_26; pfam13500 573061001436 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 573061001437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573061001438 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 573061001439 inhibitor-cofactor binding pocket; inhibition site 573061001440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061001441 catalytic residue [active] 573061001442 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 573061001443 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573061001444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061001445 DNA-binding site [nucleotide binding]; DNA binding site 573061001446 FCD domain; Region: FCD; pfam07729 573061001447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061001448 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061001449 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 573061001450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061001451 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 573061001452 putative ADP-binding pocket [chemical binding]; other site 573061001453 Putative cyclase; Region: Cyclase; pfam04199 573061001454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061001455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061001456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061001457 dimerization interface [polypeptide binding]; other site 573061001458 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573061001459 nudix motif; other site 573061001460 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 573061001461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 573061001462 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 573061001463 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 573061001464 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573061001465 FAD binding site [chemical binding]; other site 573061001466 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 573061001467 active site 573061001468 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573061001469 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 573061001470 intracellular protease, PfpI family; Region: PfpI; TIGR01382 573061001471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 573061001472 conserved cys residue [active] 573061001473 heat shock protein 90; Provisional; Region: PRK05218 573061001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061001475 ATP binding site [chemical binding]; other site 573061001476 Mg2+ binding site [ion binding]; other site 573061001477 G-X-G motif; other site 573061001478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061001479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061001480 metal binding site [ion binding]; metal-binding site 573061001481 active site 573061001482 I-site; other site 573061001483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573061001484 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 573061001485 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573061001486 DNA binding site [nucleotide binding] 573061001487 active site 573061001488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061001489 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573061001490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061001491 dimer interface [polypeptide binding]; other site 573061001492 conserved gate region; other site 573061001493 putative PBP binding loops; other site 573061001494 ABC-ATPase subunit interface; other site 573061001495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061001497 dimer interface [polypeptide binding]; other site 573061001498 conserved gate region; other site 573061001499 putative PBP binding loops; other site 573061001500 ABC-ATPase subunit interface; other site 573061001501 4-alpha-glucanotransferase; Provisional; Region: PRK14508 573061001502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061001503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061001504 DNA binding site [nucleotide binding] 573061001505 domain linker motif; other site 573061001506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573061001507 ligand binding site [chemical binding]; other site 573061001508 dimerization interface [polypeptide binding]; other site 573061001509 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061001510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061001511 DNA binding site [nucleotide binding] 573061001512 domain linker motif; other site 573061001513 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573061001514 dimerization interface [polypeptide binding]; other site 573061001515 ligand binding site [chemical binding]; other site 573061001516 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061001517 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573061001518 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573061001519 Double zinc ribbon; Region: DZR; pfam12773 573061001520 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573061001521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061001522 substrate binding pocket [chemical binding]; other site 573061001523 membrane-bound complex binding site; other site 573061001524 hinge residues; other site 573061001525 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573061001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061001527 dimer interface [polypeptide binding]; other site 573061001528 conserved gate region; other site 573061001529 putative PBP binding loops; other site 573061001530 ABC-ATPase subunit interface; other site 573061001531 sulfate transport protein; Provisional; Region: cysT; CHL00187 573061001532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061001533 dimer interface [polypeptide binding]; other site 573061001534 conserved gate region; other site 573061001535 putative PBP binding loops; other site 573061001536 ABC-ATPase subunit interface; other site 573061001537 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573061001538 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 573061001539 Walker A/P-loop; other site 573061001540 ATP binding site [chemical binding]; other site 573061001541 Q-loop/lid; other site 573061001542 ABC transporter signature motif; other site 573061001543 Walker B; other site 573061001544 D-loop; other site 573061001545 H-loop/switch region; other site 573061001546 TOBE domain; Region: TOBE_2; pfam08402 573061001547 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 573061001548 L-aspartate oxidase; Provisional; Region: PRK06175 573061001549 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573061001550 Ferredoxin [Energy production and conversion]; Region: COG1146 573061001551 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573061001552 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 573061001553 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573061001554 Active Sites [active] 573061001555 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 573061001556 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573061001557 G1 box; other site 573061001558 GTP/Mg2+ binding site [chemical binding]; other site 573061001559 G2 box; other site 573061001560 Switch I region; other site 573061001561 G3 box; other site 573061001562 Switch II region; other site 573061001563 G4 box; other site 573061001564 G5 box; other site 573061001565 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 573061001566 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 573061001567 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573061001568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061001569 dimerization interface [polypeptide binding]; other site 573061001570 putative Zn2+ binding site [ion binding]; other site 573061001571 putative DNA binding site [nucleotide binding]; other site 573061001572 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573061001573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061001574 Coenzyme A binding pocket [chemical binding]; other site 573061001575 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573061001576 EamA-like transporter family; Region: EamA; pfam00892 573061001577 EamA-like transporter family; Region: EamA; pfam00892 573061001578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001579 dimerization interface [polypeptide binding]; other site 573061001580 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001582 dimer interface [polypeptide binding]; other site 573061001583 putative CheW interface [polypeptide binding]; other site 573061001584 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573061001585 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573061001586 catalytic triad [active] 573061001587 Serine hydrolase; Region: Ser_hydrolase; pfam06821 573061001588 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573061001589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061001590 Zn2+ binding site [ion binding]; other site 573061001591 Mg2+ binding site [ion binding]; other site 573061001592 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 573061001593 dimer interface [polypeptide binding]; other site 573061001594 FMN binding site [chemical binding]; other site 573061001595 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001597 dimer interface [polypeptide binding]; other site 573061001598 putative CheW interface [polypeptide binding]; other site 573061001599 Cache domain; Region: Cache_1; pfam02743 573061001600 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001602 dimer interface [polypeptide binding]; other site 573061001603 putative CheW interface [polypeptide binding]; other site 573061001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061001605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061001607 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 573061001608 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573061001609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061001610 catalytic residue [active] 573061001611 PGAP1-like protein; Region: PGAP1; pfam07819 573061001612 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 573061001613 Cellulose binding domain; Region: CBM_3; cl03026 573061001614 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061001615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001616 dimerization interface [polypeptide binding]; other site 573061001617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001618 dimer interface [polypeptide binding]; other site 573061001619 putative CheW interface [polypeptide binding]; other site 573061001620 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061001621 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061001622 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573061001623 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573061001624 intersubunit interface [polypeptide binding]; other site 573061001625 active site 573061001626 zinc binding site [ion binding]; other site 573061001627 Na+ binding site [ion binding]; other site 573061001628 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 573061001629 active site clefts [active] 573061001630 zinc binding site [ion binding]; other site 573061001631 dimer interface [polypeptide binding]; other site 573061001632 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 573061001633 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 573061001634 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061001635 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 573061001636 Chain length determinant protein; Region: Wzz; cl15801 573061001637 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 573061001638 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573061001639 Substrate binding site; other site 573061001640 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061001641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061001642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061001643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061001644 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 573061001645 Melibiase; Region: Melibiase; pfam02065 573061001646 Right handed beta helix region; Region: Beta_helix; pfam13229 573061001647 Right handed beta helix region; Region: Beta_helix; pfam13229 573061001648 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573061001649 RHS Repeat; Region: RHS_repeat; pfam05593 573061001650 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061001651 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573061001652 RHS Repeat; Region: RHS_repeat; pfam05593 573061001653 RHS Repeat; Region: RHS_repeat; pfam05593 573061001654 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573061001655 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 573061001656 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061001657 dockerin binding interface; other site 573061001658 helicase 45; Provisional; Region: PTZ00424 573061001659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573061001660 ATP binding site [chemical binding]; other site 573061001661 putative Mg++ binding site [ion binding]; other site 573061001662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061001663 nucleotide binding region [chemical binding]; other site 573061001664 ATP-binding site [chemical binding]; other site 573061001665 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 573061001666 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 573061001667 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 573061001668 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573061001669 HAMP domain; Region: HAMP; pfam00672 573061001670 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061001671 dimerization interface [polypeptide binding]; other site 573061001672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001673 dimer interface [polypeptide binding]; other site 573061001674 putative CheW interface [polypeptide binding]; other site 573061001675 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573061001676 dimerization interface [polypeptide binding]; other site 573061001677 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061001678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001679 dimer interface [polypeptide binding]; other site 573061001680 putative CheW interface [polypeptide binding]; other site 573061001681 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573061001682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061001683 Walker A/P-loop; other site 573061001684 ATP binding site [chemical binding]; other site 573061001685 Q-loop/lid; other site 573061001686 ABC transporter signature motif; other site 573061001687 Walker B; other site 573061001688 D-loop; other site 573061001689 H-loop/switch region; other site 573061001690 Predicted transcriptional regulators [Transcription]; Region: COG1725 573061001691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061001692 DNA-binding site [nucleotide binding]; DNA binding site 573061001693 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573061001694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061001695 Walker A/P-loop; other site 573061001696 ATP binding site [chemical binding]; other site 573061001697 Q-loop/lid; other site 573061001698 ABC transporter signature motif; other site 573061001699 Walker B; other site 573061001700 D-loop; other site 573061001701 H-loop/switch region; other site 573061001702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061001703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061001704 Walker A/P-loop; other site 573061001705 ATP binding site [chemical binding]; other site 573061001706 Q-loop/lid; other site 573061001707 ABC transporter signature motif; other site 573061001708 Walker B; other site 573061001709 D-loop; other site 573061001710 H-loop/switch region; other site 573061001711 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573061001712 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061001713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061001714 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061001715 FtsX-like permease family; Region: FtsX; pfam02687 573061001716 Protein of unknown function (DUF445); Region: DUF445; pfam04286 573061001717 Protein of unknown function (DUF445); Region: DUF445; pfam04286 573061001718 xylose isomerase; Provisional; Region: PRK05474 573061001719 xylose isomerase; Region: xylose_isom_A; TIGR02630 573061001720 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 573061001721 active site 573061001722 intersubunit interactions; other site 573061001723 catalytic residue [active] 573061001724 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 573061001725 N- and C-terminal domain interface [polypeptide binding]; other site 573061001726 D-xylulose kinase; Region: XylB; TIGR01312 573061001727 active site 573061001728 MgATP binding site [chemical binding]; other site 573061001729 catalytic site [active] 573061001730 metal binding site [ion binding]; metal-binding site 573061001731 xylulose binding site [chemical binding]; other site 573061001732 homodimer interface [polypeptide binding]; other site 573061001733 methionine sulfoxide reductase A; Provisional; Region: PRK14054 573061001734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061001735 dimerization interface [polypeptide binding]; other site 573061001736 putative DNA binding site [nucleotide binding]; other site 573061001737 putative Zn2+ binding site [ion binding]; other site 573061001738 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573061001739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573061001740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573061001741 EDD domain protein, DegV family; Region: DegV; TIGR00762 573061001742 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 573061001743 Helix-turn-helix domain; Region: HTH_38; pfam13936 573061001744 Integrase core domain; Region: rve; pfam00665 573061001745 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 573061001746 Protein of unknown function, DUF624; Region: DUF624; cl02369 573061001747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061001748 binding surface 573061001749 TPR repeat; Region: TPR_11; pfam13414 573061001750 TPR motif; other site 573061001751 TPR repeat; Region: TPR_11; pfam13414 573061001752 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573061001753 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573061001754 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 573061001755 GIY-YIG motif/motif A; other site 573061001756 putative active site [active] 573061001757 putative metal binding site [ion binding]; other site 573061001758 Cache domain; Region: Cache_1; pfam02743 573061001759 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061001760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001761 dimerization interface [polypeptide binding]; other site 573061001762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061001763 dimer interface [polypeptide binding]; other site 573061001764 putative CheW interface [polypeptide binding]; other site 573061001765 Cupin domain; Region: Cupin_2; pfam07883 573061001766 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061001767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061001768 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 573061001769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061001770 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061001771 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573061001772 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573061001773 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 573061001774 ligand binding site [chemical binding]; other site 573061001775 active site 573061001776 UGI interface [polypeptide binding]; other site 573061001777 catalytic site [active] 573061001778 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573061001779 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573061001780 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573061001781 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573061001782 Walker A/P-loop; other site 573061001783 ATP binding site [chemical binding]; other site 573061001784 Q-loop/lid; other site 573061001785 ABC transporter signature motif; other site 573061001786 Walker B; other site 573061001787 D-loop; other site 573061001788 H-loop/switch region; other site 573061001789 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 573061001790 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 573061001791 Probable Catalytic site; other site 573061001792 metal-binding site 573061001793 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573061001794 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573061001795 Probable Catalytic site; other site 573061001796 metal-binding site 573061001797 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 573061001798 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 573061001799 Ligand binding site; other site 573061001800 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 573061001801 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 573061001802 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573061001803 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573061001804 Probable Catalytic site; other site 573061001805 metal-binding site 573061001806 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 573061001807 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 573061001808 PAS domain S-box; Region: sensory_box; TIGR00229 573061001809 PAS domain; Region: PAS_8; pfam13188 573061001810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061001811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061001812 metal binding site [ion binding]; metal-binding site 573061001813 active site 573061001814 I-site; other site 573061001815 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 573061001816 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061001817 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061001818 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061001819 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 573061001820 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 573061001821 active site 573061001822 metal binding site [ion binding]; metal-binding site 573061001823 DNA binding site [nucleotide binding] 573061001824 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 573061001825 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 573061001826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061001827 Walker A/P-loop; other site 573061001828 ATP binding site [chemical binding]; other site 573061001829 Q-loop/lid; other site 573061001830 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 573061001831 ABC transporter signature motif; other site 573061001832 Walker B; other site 573061001833 D-loop; other site 573061001834 H-loop/switch region; other site 573061001835 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573061001836 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573061001837 Catalytic site [active] 573061001838 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573061001839 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573061001840 Catalytic site [active] 573061001841 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573061001842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061001843 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 573061001844 Part of AAA domain; Region: AAA_19; pfam13245 573061001845 Family description; Region: UvrD_C_2; pfam13538 573061001846 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061001847 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 573061001848 putative active site [active] 573061001849 putative metal binding site [ion binding]; other site 573061001850 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573061001851 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 573061001852 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 573061001853 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 573061001854 tetrameric interface [polypeptide binding]; other site 573061001855 activator binding site; other site 573061001856 NADP binding site [chemical binding]; other site 573061001857 substrate binding site [chemical binding]; other site 573061001858 catalytic residues [active] 573061001859 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 573061001860 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 573061001861 active site 573061001862 metal binding site [ion binding]; metal-binding site 573061001863 RNA polymerase factor sigma-70; Validated; Region: PRK06811 573061001864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061001865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061001866 DNA binding residues [nucleotide binding] 573061001867 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 573061001868 aspartate kinase; Reviewed; Region: PRK06635 573061001869 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 573061001870 putative nucleotide binding site [chemical binding]; other site 573061001871 putative catalytic residues [active] 573061001872 putative Mg ion binding site [ion binding]; other site 573061001873 putative aspartate binding site [chemical binding]; other site 573061001874 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 573061001875 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 573061001876 putative allosteric regulatory residue; other site 573061001877 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573061001878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573061001879 active site 573061001880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573061001881 substrate binding site [chemical binding]; other site 573061001882 catalytic residues [active] 573061001883 dimer interface [polypeptide binding]; other site 573061001884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061001885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061001886 non-specific DNA binding site [nucleotide binding]; other site 573061001887 salt bridge; other site 573061001888 sequence-specific DNA binding site [nucleotide binding]; other site 573061001889 B12 binding domain; Region: B12-binding_2; pfam02607 573061001890 B12 binding domain; Region: B12-binding; pfam02310 573061001891 B12 binding site [chemical binding]; other site 573061001892 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 573061001893 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 573061001894 B12 binding site [chemical binding]; other site 573061001895 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573061001896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061001897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061001898 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061001899 Walker A/P-loop; other site 573061001900 ATP binding site [chemical binding]; other site 573061001901 Q-loop/lid; other site 573061001902 ABC transporter signature motif; other site 573061001903 Walker B; other site 573061001904 D-loop; other site 573061001905 H-loop/switch region; other site 573061001906 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061001907 Interdomain contacts; other site 573061001908 Cytokine receptor motif; other site 573061001909 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 573061001910 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 573061001911 putative ligand binding site [chemical binding]; other site 573061001912 putative NAD binding site [chemical binding]; other site 573061001913 catalytic site [active] 573061001914 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 573061001915 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 573061001916 G1 box; other site 573061001917 putative GEF interaction site [polypeptide binding]; other site 573061001918 GTP/Mg2+ binding site [chemical binding]; other site 573061001919 Switch I region; other site 573061001920 G2 box; other site 573061001921 G3 box; other site 573061001922 Switch II region; other site 573061001923 G4 box; other site 573061001924 G5 box; other site 573061001925 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 573061001926 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 573061001927 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 573061001928 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 573061001929 Putative glucoamylase; Region: Glycoamylase; pfam10091 573061001930 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 573061001931 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 573061001932 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 573061001933 Protein of unknown function, DUF608; Region: DUF608; pfam04685 573061001934 Putative amidase domain; Region: Amidase_6; pfam12671 573061001935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573061001936 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573061001937 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573061001938 active site 573061001939 HIGH motif; other site 573061001940 dimer interface [polypeptide binding]; other site 573061001941 KMSKS motif; other site 573061001942 manganese transport protein MntH; Reviewed; Region: PRK00701 573061001943 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573061001944 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 573061001945 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 573061001946 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 573061001947 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 573061001948 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573061001949 DEAD_2; Region: DEAD_2; pfam06733 573061001950 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 573061001951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573061001952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573061001953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061001954 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 573061001955 Walker A/P-loop; other site 573061001956 ATP binding site [chemical binding]; other site 573061001957 Q-loop/lid; other site 573061001958 ABC transporter signature motif; other site 573061001959 Walker B; other site 573061001960 D-loop; other site 573061001961 H-loop/switch region; other site 573061001962 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 573061001963 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 573061001964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061001965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061001966 dimerization interface [polypeptide binding]; other site 573061001967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061001968 dimer interface [polypeptide binding]; other site 573061001969 phosphorylation site [posttranslational modification] 573061001970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061001971 ATP binding site [chemical binding]; other site 573061001972 Mg2+ binding site [ion binding]; other site 573061001973 G-X-G motif; other site 573061001974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061001976 active site 573061001977 phosphorylation site [posttranslational modification] 573061001978 intermolecular recognition site; other site 573061001979 dimerization interface [polypeptide binding]; other site 573061001980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061001981 DNA binding site [nucleotide binding] 573061001982 sugar phosphate phosphatase; Provisional; Region: PRK10513 573061001983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061001984 active site 573061001985 motif I; other site 573061001986 motif II; other site 573061001987 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061001988 AAA domain; Region: AAA_28; pfam13521 573061001989 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 573061001990 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 573061001991 G1 box; other site 573061001992 putative GEF interaction site [polypeptide binding]; other site 573061001993 GTP/Mg2+ binding site [chemical binding]; other site 573061001994 Switch I region; other site 573061001995 G2 box; other site 573061001996 G3 box; other site 573061001997 Switch II region; other site 573061001998 G4 box; other site 573061001999 G5 box; other site 573061002000 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 573061002001 FOG: CBS domain [General function prediction only]; Region: COG0517 573061002002 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573061002003 Probable zinc-binding domain; Region: zf-trcl; pfam13451 573061002004 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 573061002005 Divergent AAA domain; Region: AAA_4; pfam04326 573061002006 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573061002007 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573061002008 active site 573061002009 HIGH motif; other site 573061002010 dimer interface [polypeptide binding]; other site 573061002011 KMSKS motif; other site 573061002012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061002013 RNA binding surface [nucleotide binding]; other site 573061002014 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573061002015 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 573061002016 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061002017 putative active site [active] 573061002018 putative metal binding site [ion binding]; other site 573061002019 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 573061002020 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573061002021 dimerization interface 3.5A [polypeptide binding]; other site 573061002022 active site 573061002023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061002024 dimerization interface [polypeptide binding]; other site 573061002025 putative DNA binding site [nucleotide binding]; other site 573061002026 putative Zn2+ binding site [ion binding]; other site 573061002027 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 573061002028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061002029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061002030 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573061002031 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573061002032 active site residue [active] 573061002033 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 573061002034 CPxP motif; other site 573061002035 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 573061002036 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061002037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002038 dimer interface [polypeptide binding]; other site 573061002039 putative CheW interface [polypeptide binding]; other site 573061002040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 573061002041 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 573061002042 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 573061002043 putative dimer interface [polypeptide binding]; other site 573061002044 catalytic triad [active] 573061002045 putative acetyltransferase YhhY; Provisional; Region: PRK10140 573061002046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002047 Coenzyme A binding pocket [chemical binding]; other site 573061002048 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573061002049 thiamine phosphate binding site [chemical binding]; other site 573061002050 active site 573061002051 pyrophosphate binding site [ion binding]; other site 573061002052 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 573061002053 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 573061002054 ATP binding site [chemical binding]; other site 573061002055 substrate interface [chemical binding]; other site 573061002056 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 573061002057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061002058 FeS/SAM binding site; other site 573061002059 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573061002060 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 573061002061 ThiS interaction site; other site 573061002062 putative active site [active] 573061002063 tetramer interface [polypeptide binding]; other site 573061002064 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 573061002065 thiS-thiF/thiG interaction site; other site 573061002066 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 573061002067 Predicted membrane protein [Function unknown]; Region: COG2323 573061002068 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 573061002069 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 573061002070 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 573061002071 active site 573061002072 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 573061002073 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573061002074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061002075 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 573061002076 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 573061002077 nucleotide binding site/active site [active] 573061002078 HIT family signature motif; other site 573061002079 catalytic residue [active] 573061002080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061002081 binding surface 573061002082 TPR motif; other site 573061002083 TPR repeat; Region: TPR_11; pfam13414 573061002084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061002085 binding surface 573061002086 TPR motif; other site 573061002087 TPR repeat; Region: TPR_11; pfam13414 573061002088 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061002089 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573061002090 Domain of unknown function (DUF3517); Region: DUF3517; pfam12030 573061002091 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061002092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061002093 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061002094 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061002095 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573061002096 FMN-binding domain; Region: FMN_bind; cl01081 573061002097 FMN-binding domain; Region: FMN_bind; cl01081 573061002098 FMN-binding domain; Region: FMN_bind; cl01081 573061002099 FMN-binding domain; Region: FMN_bind; cl01081 573061002100 FMN-binding domain; Region: FMN_bind; cl01081 573061002101 FMN-binding domain; Region: FMN_bind; cl01081 573061002102 FMN-binding domain; Region: FMN_bind; cl01081 573061002103 FMN-binding domain; Region: FMN_bind; cl01081 573061002104 FMN-binding domain; Region: FMN_bind; cl01081 573061002105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061002106 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061002107 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 573061002108 ApbE family; Region: ApbE; pfam02424 573061002109 PAS domain; Region: PAS_9; pfam13426 573061002110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573061002111 putative active site [active] 573061002112 heme pocket [chemical binding]; other site 573061002113 PAS domain S-box; Region: sensory_box; TIGR00229 573061002114 PAS domain; Region: PAS; smart00091 573061002115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 573061002116 putative active site [active] 573061002117 heme pocket [chemical binding]; other site 573061002118 PAS domain S-box; Region: sensory_box; TIGR00229 573061002119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573061002120 putative active site [active] 573061002121 heme pocket [chemical binding]; other site 573061002122 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573061002123 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573061002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573061002125 ATP binding site [chemical binding]; other site 573061002126 Mg2+ binding site [ion binding]; other site 573061002127 G-X-G motif; other site 573061002128 Cache domain; Region: Cache_1; pfam02743 573061002129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061002130 dimerization interface [polypeptide binding]; other site 573061002131 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061002132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002133 dimer interface [polypeptide binding]; other site 573061002134 putative CheW interface [polypeptide binding]; other site 573061002135 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573061002136 anti sigma factor interaction site; other site 573061002137 regulatory phosphorylation site [posttranslational modification]; other site 573061002138 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573061002139 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 573061002140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061002141 active site 573061002142 motif I; other site 573061002143 motif II; other site 573061002144 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061002145 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573061002146 EDD domain protein, DegV family; Region: DegV; TIGR00762 573061002147 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 573061002148 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573061002149 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 573061002150 ligand binding site [chemical binding]; other site 573061002151 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573061002152 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573061002153 Walker A/P-loop; other site 573061002154 ATP binding site [chemical binding]; other site 573061002155 Q-loop/lid; other site 573061002156 ABC transporter signature motif; other site 573061002157 Walker B; other site 573061002158 D-loop; other site 573061002159 H-loop/switch region; other site 573061002160 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573061002161 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061002162 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573061002163 TM-ABC transporter signature motif; other site 573061002164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061002165 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573061002166 TM-ABC transporter signature motif; other site 573061002167 Cache domain; Region: Cache_1; pfam02743 573061002168 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061002169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061002170 dimerization interface [polypeptide binding]; other site 573061002171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002172 dimer interface [polypeptide binding]; other site 573061002173 putative CheW interface [polypeptide binding]; other site 573061002174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061002175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002176 Coenzyme A binding pocket [chemical binding]; other site 573061002177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061002178 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061002179 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573061002180 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573061002181 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 573061002182 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573061002183 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573061002184 Phosphoglycerate kinase; Region: PGK; pfam00162 573061002185 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 573061002186 substrate binding site [chemical binding]; other site 573061002187 hinge regions; other site 573061002188 ADP binding site [chemical binding]; other site 573061002189 catalytic site [active] 573061002190 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573061002191 triosephosphate isomerase; Provisional; Region: PRK14565 573061002192 substrate binding site [chemical binding]; other site 573061002193 dimer interface [polypeptide binding]; other site 573061002194 catalytic triad [active] 573061002195 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 573061002196 phosphoglyceromutase; Provisional; Region: PRK05434 573061002197 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573061002198 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 573061002199 active site 573061002200 TDP-binding site; other site 573061002201 acceptor substrate-binding pocket; other site 573061002202 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573061002203 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 573061002204 active site 573061002205 TDP-binding site; other site 573061002206 acceptor substrate-binding pocket; other site 573061002207 homodimer interface [polypeptide binding]; other site 573061002208 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061002209 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061002210 acyl-activating enzyme (AAE) consensus motif; other site 573061002211 AMP binding site [chemical binding]; other site 573061002212 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061002213 Condensation domain; Region: Condensation; pfam00668 573061002214 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061002215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061002216 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061002217 acyl-activating enzyme (AAE) consensus motif; other site 573061002218 AMP binding site [chemical binding]; other site 573061002219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061002220 thioester reductase domain; Region: Thioester-redct; TIGR01746 573061002221 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 573061002222 putative NAD(P) binding site [chemical binding]; other site 573061002223 active site 573061002224 putative substrate binding site [chemical binding]; other site 573061002225 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573061002226 catalytic triad [active] 573061002227 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061002228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061002229 substrate binding pocket [chemical binding]; other site 573061002230 membrane-bound complex binding site; other site 573061002231 hinge residues; other site 573061002232 enolase; Provisional; Region: eno; PRK00077 573061002233 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573061002234 dimer interface [polypeptide binding]; other site 573061002235 metal binding site [ion binding]; metal-binding site 573061002236 substrate binding pocket [chemical binding]; other site 573061002237 Preprotein translocase SecG subunit; Region: SecG; pfam03840 573061002238 ribonuclease R; Region: RNase_R; TIGR02063 573061002239 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 573061002240 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573061002241 RNB domain; Region: RNB; pfam00773 573061002242 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 573061002243 RNA binding site [nucleotide binding]; other site 573061002244 Right handed beta helix region; Region: Beta_helix; pfam13229 573061002245 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 573061002246 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573061002247 SmpB-tmRNA interface; other site 573061002248 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 573061002249 classical (c) SDRs; Region: SDR_c; cd05233 573061002250 NAD(P) binding site [chemical binding]; other site 573061002251 active site 573061002252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 573061002253 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573061002254 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061002255 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 573061002256 putative active site [active] 573061002257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061002259 Walker A/P-loop; other site 573061002260 ATP binding site [chemical binding]; other site 573061002261 Q-loop/lid; other site 573061002262 ABC transporter signature motif; other site 573061002263 Walker B; other site 573061002264 D-loop; other site 573061002265 H-loop/switch region; other site 573061002266 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061002267 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 573061002268 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061002269 cofactor binding site; other site 573061002270 DNA binding site [nucleotide binding] 573061002271 substrate interaction site [chemical binding]; other site 573061002272 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061002273 Domain of unknown function (DUF955); Region: DUF955; pfam06114 573061002274 Double zinc ribbon; Region: DZR; pfam12773 573061002275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061002276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002277 non-specific DNA binding site [nucleotide binding]; other site 573061002278 salt bridge; other site 573061002279 sequence-specific DNA binding site [nucleotide binding]; other site 573061002280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002281 non-specific DNA binding site [nucleotide binding]; other site 573061002282 salt bridge; other site 573061002283 sequence-specific DNA binding site [nucleotide binding]; other site 573061002284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002285 non-specific DNA binding site [nucleotide binding]; other site 573061002286 salt bridge; other site 573061002287 sequence-specific DNA binding site [nucleotide binding]; other site 573061002288 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 573061002289 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 573061002290 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 573061002291 DNA binding site [nucleotide binding] 573061002292 active site 573061002293 catalytic site [active] 573061002294 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 573061002295 Virulence-associated protein E; Region: VirE; pfam05272 573061002296 VRR-NUC domain; Region: VRR_NUC; pfam08774 573061002297 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 573061002298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061002299 ATP binding site [chemical binding]; other site 573061002300 putative Mg++ binding site [ion binding]; other site 573061002301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061002302 nucleotide binding region [chemical binding]; other site 573061002303 ATP-binding site [chemical binding]; other site 573061002304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061002305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002306 non-specific DNA binding site [nucleotide binding]; other site 573061002307 salt bridge; other site 573061002308 sequence-specific DNA binding site [nucleotide binding]; other site 573061002309 Domain of unknown function (DUF955); Region: DUF955; pfam06114 573061002310 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573061002311 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061002312 active site 573061002313 NUMOD4 motif; Region: NUMOD4; pfam07463 573061002314 HNH endonuclease; Region: HNH_3; pfam13392 573061002315 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573061002316 ParB-like nuclease domain; Region: ParB; smart00470 573061002317 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573061002318 DNA methylase; Region: N6_N4_Mtase; pfam01555 573061002319 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061002320 cofactor binding site; other site 573061002321 DNA binding site [nucleotide binding] 573061002322 substrate interaction site [chemical binding]; other site 573061002323 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061002324 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 573061002325 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573061002326 putative active site pocket [active] 573061002327 dimerization interface [polypeptide binding]; other site 573061002328 putative catalytic residue [active] 573061002329 Phage terminase, small subunit; Region: Terminase_4; pfam05119 573061002330 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573061002331 Phage portal protein; Region: Phage_portal; pfam04860 573061002332 Phage-related protein [Function unknown]; Region: COG4695 573061002333 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573061002334 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573061002335 Phage capsid family; Region: Phage_capsid; pfam05065 573061002336 Nuclease-related domain; Region: NERD; pfam08378 573061002337 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 573061002338 oligomerization interface [polypeptide binding]; other site 573061002339 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 573061002340 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 573061002341 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 573061002342 Phage-related protein [Function unknown]; Region: COG5412 573061002343 Phage tail protein; Region: Sipho_tail; cl17486 573061002344 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 573061002345 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573061002346 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 573061002347 Holin family; Region: Phage_holin_4; pfam05105 573061002348 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573061002349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573061002350 active site 573061002351 metal binding site [ion binding]; metal-binding site 573061002352 Sporulation related domain; Region: SPOR; pfam05036 573061002353 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573061002354 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061002355 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061002356 catalytic residues [active] 573061002357 catalytic nucleophile [active] 573061002358 Recombinase; Region: Recombinase; pfam07508 573061002359 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061002360 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061002361 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061002362 catalytic residues [active] 573061002363 catalytic nucleophile [active] 573061002364 Recombinase; Region: Recombinase; pfam07508 573061002365 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061002366 Caspase domain; Region: Peptidase_C14; pfam00656 573061002367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 573061002368 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 573061002369 putative transposase OrfB; Reviewed; Region: PHA02517 573061002370 HTH-like domain; Region: HTH_21; pfam13276 573061002371 Integrase core domain; Region: rve; pfam00665 573061002372 Integrase core domain; Region: rve_3; pfam13683 573061002373 Homeodomain-like domain; Region: HTH_23; cl17451 573061002374 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061002375 ZIP Zinc transporter; Region: Zip; pfam02535 573061002376 N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141 573061002377 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061002378 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 573061002379 putative active site [active] 573061002380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061002382 Walker A/P-loop; other site 573061002383 ATP binding site [chemical binding]; other site 573061002384 Q-loop/lid; other site 573061002385 ABC transporter signature motif; other site 573061002386 Walker B; other site 573061002387 D-loop; other site 573061002388 H-loop/switch region; other site 573061002389 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573061002390 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573061002391 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061002392 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061002393 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573061002394 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573061002395 active site 573061002396 catalytic site [active] 573061002397 substrate binding site [chemical binding]; other site 573061002398 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573061002399 Dimer interface [polypeptide binding]; other site 573061002400 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 573061002401 AAA ATPase domain; Region: AAA_16; pfam13191 573061002402 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 573061002403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061002404 ATP binding site [chemical binding]; other site 573061002405 putative Mg++ binding site [ion binding]; other site 573061002406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 573061002407 nucleotide binding region [chemical binding]; other site 573061002408 ATP-binding site [chemical binding]; other site 573061002409 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061002410 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 573061002411 active site 573061002412 metal binding site [ion binding]; metal-binding site 573061002413 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 573061002414 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573061002415 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 573061002416 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 573061002417 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 573061002418 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 573061002419 Part of AAA domain; Region: AAA_19; pfam13245 573061002420 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 573061002421 AAA domain; Region: AAA_30; pfam13604 573061002422 AAA domain; Region: AAA_12; pfam13087 573061002423 Helix-turn-helix domain; Region: HTH_17; pfam12728 573061002424 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 573061002425 polymerase nucleotide-binding site; other site 573061002426 DNA-binding residues [nucleotide binding]; DNA binding site 573061002427 nucleotide binding site [chemical binding]; other site 573061002428 primase nucleotide-binding site [nucleotide binding]; other site 573061002429 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 573061002430 Domain of unknown function (DUF927); Region: DUF927; cl12098 573061002431 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573061002432 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061002433 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061002434 catalytic residues [active] 573061002435 catalytic nucleophile [active] 573061002436 Recombinase; Region: Recombinase; pfam07508 573061002437 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061002438 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061002439 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061002440 catalytic residues [active] 573061002441 catalytic nucleophile [active] 573061002442 Recombinase; Region: Recombinase; pfam07508 573061002443 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061002444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061002445 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 573061002446 putative active site [active] 573061002447 putative metal binding site [ion binding]; other site 573061002448 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061002449 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061002450 active site 573061002451 metal binding site [ion binding]; metal-binding site 573061002452 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061002453 LytTr DNA-binding domain; Region: LytTR; smart00850 573061002454 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573061002455 ATP binding site [chemical binding]; other site 573061002456 Mg2+ binding site [ion binding]; other site 573061002457 G-X-G motif; other site 573061002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061002459 putative substrate translocation pore; other site 573061002460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061002461 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573061002462 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 573061002463 metal binding site [ion binding]; metal-binding site 573061002464 putative dimer interface [polypeptide binding]; other site 573061002465 Stage II sporulation protein; Region: SpoIID; pfam08486 573061002466 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061002467 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061002468 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061002469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061002470 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061002471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061002473 Walker A/P-loop; other site 573061002474 ATP binding site [chemical binding]; other site 573061002475 Q-loop/lid; other site 573061002476 ABC transporter signature motif; other site 573061002477 Walker B; other site 573061002478 D-loop; other site 573061002479 H-loop/switch region; other site 573061002480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061002481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061002483 Walker A/P-loop; other site 573061002484 ATP binding site [chemical binding]; other site 573061002485 Q-loop/lid; other site 573061002486 ABC transporter signature motif; other site 573061002487 Walker B; other site 573061002488 D-loop; other site 573061002489 H-loop/switch region; other site 573061002490 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 573061002491 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573061002492 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573061002493 Coat F domain; Region: Coat_F; pfam07875 573061002494 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573061002495 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 573061002496 siderophore binding site; other site 573061002497 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573061002498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573061002499 ABC-ATPase subunit interface; other site 573061002500 dimer interface [polypeptide binding]; other site 573061002501 putative PBP binding regions; other site 573061002502 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 573061002503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573061002504 ABC-ATPase subunit interface; other site 573061002505 dimer interface [polypeptide binding]; other site 573061002506 putative PBP binding regions; other site 573061002507 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573061002508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573061002509 Walker A/P-loop; other site 573061002510 ATP binding site [chemical binding]; other site 573061002511 Q-loop/lid; other site 573061002512 ABC transporter signature motif; other site 573061002513 Walker B; other site 573061002514 D-loop; other site 573061002515 H-loop/switch region; other site 573061002516 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 573061002517 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 573061002518 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061002519 active site 573061002520 zinc binding site [ion binding]; other site 573061002521 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061002522 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061002523 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573061002524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061002525 active site 573061002526 motif I; other site 573061002527 motif II; other site 573061002528 DTW domain; Region: DTW; cl01221 573061002529 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573061002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061002531 motif II; other site 573061002532 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573061002533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061002534 NAD(P) binding site [chemical binding]; other site 573061002535 active site 573061002536 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573061002537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061002538 S-adenosylmethionine binding site [chemical binding]; other site 573061002539 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061002540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002541 Coenzyme A binding pocket [chemical binding]; other site 573061002542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061002543 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061002544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002545 dimer interface [polypeptide binding]; other site 573061002546 putative CheW interface [polypeptide binding]; other site 573061002547 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 573061002548 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 573061002549 active site 573061002550 AMP-binding domain protein; Validated; Region: PRK08315 573061002551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061002552 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 573061002553 acyl-activating enzyme (AAE) consensus motif; other site 573061002554 acyl-activating enzyme (AAE) consensus motif; other site 573061002555 putative AMP binding site [chemical binding]; other site 573061002556 putative active site [active] 573061002557 putative CoA binding site [chemical binding]; other site 573061002558 Chain length determinant protein; Region: Wzz; cl15801 573061002559 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 573061002560 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061002561 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573061002562 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 573061002563 putative ligand binding site [chemical binding]; other site 573061002564 putative catalytic site [active] 573061002565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061002566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573061002567 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573061002568 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573061002569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573061002570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061002571 NAD(P) binding site [chemical binding]; other site 573061002572 active site 573061002573 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 573061002574 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061002575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002576 active site 573061002577 phosphorylation site [posttranslational modification] 573061002578 intermolecular recognition site; other site 573061002579 dimerization interface [polypeptide binding]; other site 573061002580 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061002581 DNA binding site [nucleotide binding] 573061002582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061002583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573061002584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061002585 ATP binding site [chemical binding]; other site 573061002586 Mg2+ binding site [ion binding]; other site 573061002587 G-X-G motif; other site 573061002588 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061002589 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061002590 Walker A/P-loop; other site 573061002591 ATP binding site [chemical binding]; other site 573061002592 Q-loop/lid; other site 573061002593 ABC transporter signature motif; other site 573061002594 Walker B; other site 573061002595 D-loop; other site 573061002596 H-loop/switch region; other site 573061002597 FtsX-like permease family; Region: FtsX; pfam02687 573061002598 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061002599 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 573061002600 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 573061002601 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 573061002602 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061002603 putative active site [active] 573061002604 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 573061002605 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 573061002606 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573061002607 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 573061002608 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 573061002609 active site 573061002610 catalytic site [active] 573061002611 substrate binding site [chemical binding]; other site 573061002612 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573061002613 Dimer interface [polypeptide binding]; other site 573061002614 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573061002615 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061002616 DNA binding residues [nucleotide binding] 573061002617 dimer interface [polypeptide binding]; other site 573061002618 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 573061002619 active site 573061002620 catalytic triad [active] 573061002621 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061002622 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061002623 CARDB; Region: CARDB; pfam07705 573061002624 CARDB; Region: CARDB; pfam07705 573061002625 CARDB; Region: CARDB; pfam07705 573061002626 CARDB; Region: CARDB; pfam07705 573061002627 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061002628 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061002629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061002630 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573061002631 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573061002632 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 573061002633 putative active site [active] 573061002634 putative catalytic site [active] 573061002635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061002636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002637 active site 573061002638 phosphorylation site [posttranslational modification] 573061002639 intermolecular recognition site; other site 573061002640 dimerization interface [polypeptide binding]; other site 573061002641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061002642 DNA binding site [nucleotide binding] 573061002643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061002644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061002645 dimerization interface [polypeptide binding]; other site 573061002646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061002647 dimer interface [polypeptide binding]; other site 573061002648 phosphorylation site [posttranslational modification] 573061002649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061002650 ATP binding site [chemical binding]; other site 573061002651 Mg2+ binding site [ion binding]; other site 573061002652 G-X-G motif; other site 573061002653 DJ-1 family protein; Region: not_thiJ; TIGR01383 573061002654 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 573061002655 conserved cys residue [active] 573061002656 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061002657 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061002658 ligand binding site [chemical binding]; other site 573061002659 calcium binding site [ion binding]; other site 573061002660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573061002661 K+ potassium transporter; Region: K_trans; cl15781 573061002662 Histidine kinase; Region: HisKA_3; pfam07730 573061002663 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573061002664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061002665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002666 active site 573061002667 phosphorylation site [posttranslational modification] 573061002668 intermolecular recognition site; other site 573061002669 dimerization interface [polypeptide binding]; other site 573061002670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061002671 DNA binding residues [nucleotide binding] 573061002672 dimerization interface [polypeptide binding]; other site 573061002673 short chain dehydrogenase; Provisional; Region: PRK06940 573061002674 classical (c) SDRs; Region: SDR_c; cd05233 573061002675 NAD(P) binding site [chemical binding]; other site 573061002676 active site 573061002677 classical (c) SDRs; Region: SDR_c; cd05233 573061002678 short chain dehydrogenase; Provisional; Region: PRK06181 573061002679 NAD(P) binding site [chemical binding]; other site 573061002680 active site 573061002681 Protein of unknown function (DUF975); Region: DUF975; cl10504 573061002682 endoglucanase; Region: PLN02420 573061002683 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 573061002684 Cellulose binding domain; Region: CBM_3; cl03026 573061002685 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002686 ParB-like nuclease domain; Region: ParBc; pfam02195 573061002687 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 573061002688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061002689 active site 573061002690 nucleotide binding site [chemical binding]; other site 573061002691 HIGH motif; other site 573061002692 KMSKS motif; other site 573061002693 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573061002694 anticodon binding site; other site 573061002695 tRNA binding surface [nucleotide binding]; other site 573061002696 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061002697 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061002698 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573061002699 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 573061002700 flavodoxin; Provisional; Region: PRK06242 573061002701 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573061002702 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573061002703 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 573061002704 active site 573061002705 catalytic triad [active] 573061002706 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573061002707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061002708 FeS/SAM binding site; other site 573061002709 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061002710 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573061002711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061002712 FeS/SAM binding site; other site 573061002713 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061002714 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061002715 active site 573061002716 metal binding site [ion binding]; metal-binding site 573061002717 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 573061002718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002719 active site 573061002720 phosphorylation site [posttranslational modification] 573061002721 intermolecular recognition site; other site 573061002722 dimerization interface [polypeptide binding]; other site 573061002723 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061002724 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573061002725 Histidine kinase; Region: His_kinase; pfam06580 573061002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061002727 ATP binding site [chemical binding]; other site 573061002728 Mg2+ binding site [ion binding]; other site 573061002729 G-X-G motif; other site 573061002730 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573061002731 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061002732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002733 Coenzyme A binding pocket [chemical binding]; other site 573061002734 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 573061002735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061002736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061002737 DNA binding residues [nucleotide binding] 573061002738 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 573061002739 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061002740 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061002741 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573061002742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061002743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061002744 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573061002745 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573061002746 active site 573061002747 Response regulator receiver domain; Region: Response_reg; pfam00072 573061002748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002749 active site 573061002750 phosphorylation site [posttranslational modification] 573061002751 intermolecular recognition site; other site 573061002752 dimerization interface [polypeptide binding]; other site 573061002753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061002754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061002755 dimer interface [polypeptide binding]; other site 573061002756 phosphorylation site [posttranslational modification] 573061002757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061002758 ATP binding site [chemical binding]; other site 573061002759 Mg2+ binding site [ion binding]; other site 573061002760 G-X-G motif; other site 573061002761 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573061002762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573061002763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061002764 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573061002765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573061002766 active site 573061002767 Response regulator receiver domain; Region: Response_reg; pfam00072 573061002768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002769 active site 573061002770 phosphorylation site [posttranslational modification] 573061002771 intermolecular recognition site; other site 573061002772 dimerization interface [polypeptide binding]; other site 573061002773 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573061002774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573061002775 PAS domain; Region: PAS_9; pfam13426 573061002776 putative active site [active] 573061002777 heme pocket [chemical binding]; other site 573061002778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061002779 dimer interface [polypeptide binding]; other site 573061002780 phosphorylation site [posttranslational modification] 573061002781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061002782 ATP binding site [chemical binding]; other site 573061002783 Mg2+ binding site [ion binding]; other site 573061002784 G-X-G motif; other site 573061002785 Response regulator receiver domain; Region: Response_reg; pfam00072 573061002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061002787 active site 573061002788 phosphorylation site [posttranslational modification] 573061002789 intermolecular recognition site; other site 573061002790 dimerization interface [polypeptide binding]; other site 573061002791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573061002792 active site 573061002793 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573061002794 endonuclease IV; Provisional; Region: PRK01060 573061002795 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573061002796 AP (apurinic/apyrimidinic) site pocket; other site 573061002797 DNA interaction; other site 573061002798 Metal-binding active site; metal-binding site 573061002799 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 573061002800 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061002801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061002802 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061002804 Walker A/P-loop; other site 573061002805 ATP binding site [chemical binding]; other site 573061002806 Q-loop/lid; other site 573061002807 ABC transporter signature motif; other site 573061002808 Walker B; other site 573061002809 D-loop; other site 573061002810 H-loop/switch region; other site 573061002811 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061002812 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061002813 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061002814 Walker A/P-loop; other site 573061002815 ATP binding site [chemical binding]; other site 573061002816 Q-loop/lid; other site 573061002817 ABC transporter signature motif; other site 573061002818 Walker B; other site 573061002819 D-loop; other site 573061002820 H-loop/switch region; other site 573061002821 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 573061002822 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061002823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061002824 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 573061002825 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 573061002826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061002827 FeS/SAM binding site; other site 573061002828 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573061002829 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061002830 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061002831 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061002832 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 573061002833 active site 573061002834 Kelch motif; Region: Kelch_6; pfam13964 573061002835 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061002836 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061002837 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061002838 Interdomain contacts; other site 573061002839 Cytokine receptor motif; other site 573061002840 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061002841 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061002842 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061002843 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002844 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002845 Helix-turn-helix domain; Region: HTH_38; pfam13936 573061002846 Integrase core domain; Region: rve; pfam00665 573061002847 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 573061002848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061002849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002850 non-specific DNA binding site [nucleotide binding]; other site 573061002851 salt bridge; other site 573061002852 sequence-specific DNA binding site [nucleotide binding]; other site 573061002853 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061002854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002855 Coenzyme A binding pocket [chemical binding]; other site 573061002856 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061002857 Interdomain contacts; other site 573061002858 Cytokine receptor motif; other site 573061002859 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061002860 Interdomain contacts; other site 573061002861 Short C-terminal domain; Region: SHOCT; pfam09851 573061002862 hypothetical protein; Provisional; Region: PRK06194 573061002863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061002864 NAD(P) binding site [chemical binding]; other site 573061002865 active site 573061002866 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573061002867 active site 573061002868 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061002869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002870 dimer interface [polypeptide binding]; other site 573061002871 putative CheW interface [polypeptide binding]; other site 573061002872 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 573061002873 SpoOM protein; Region: Spo0M; pfam07070 573061002874 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573061002875 Peptidase family M23; Region: Peptidase_M23; pfam01551 573061002876 Pectate lyase; Region: Pec_lyase_C; cl01593 573061002877 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002878 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002879 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573061002880 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573061002881 ligand binding site [chemical binding]; other site 573061002882 flexible hinge region; other site 573061002883 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573061002884 non-specific DNA interactions [nucleotide binding]; other site 573061002885 DNA binding site [nucleotide binding] 573061002886 sequence specific DNA binding site [nucleotide binding]; other site 573061002887 putative cAMP binding site [chemical binding]; other site 573061002888 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 573061002889 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 573061002890 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 573061002891 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 573061002892 FAD binding pocket [chemical binding]; other site 573061002893 FAD binding motif [chemical binding]; other site 573061002894 phosphate binding motif [ion binding]; other site 573061002895 beta-alpha-beta structure motif; other site 573061002896 NAD binding pocket [chemical binding]; other site 573061002897 Iron coordination center [ion binding]; other site 573061002898 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 573061002899 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573061002900 4Fe-4S binding domain; Region: Fer4; pfam00037 573061002901 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061002902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061002903 non-specific DNA binding site [nucleotide binding]; other site 573061002904 salt bridge; other site 573061002905 sequence-specific DNA binding site [nucleotide binding]; other site 573061002906 Helix-turn-helix domain; Region: HTH_18; pfam12833 573061002907 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061002908 substrate binding site [chemical binding]; other site 573061002909 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573061002910 active site 573061002911 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 573061002912 metal binding site [ion binding]; metal-binding site 573061002913 active site 573061002914 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002915 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061002916 Pectate lyase; Region: Pec_lyase_C; cl01593 573061002917 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 573061002918 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 573061002919 SPRY domain-like in bacteria; Region: SPRY_like; cd12886 573061002920 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061002921 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061002922 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061002923 dockerin binding interface; other site 573061002924 SPRY domain-like in bacteria; Region: SPRY_like; cd12886 573061002925 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061002926 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061002927 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061002928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061002929 Coenzyme A binding pocket [chemical binding]; other site 573061002930 transcriptional antiterminator BglG; Provisional; Region: PRK09772 573061002931 CAT RNA binding domain; Region: CAT_RBD; smart01061 573061002932 PRD domain; Region: PRD; pfam00874 573061002933 PRD domain; Region: PRD; pfam00874 573061002934 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 573061002935 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573061002936 active site turn [active] 573061002937 phosphorylation site [posttranslational modification] 573061002938 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573061002939 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 573061002940 HPr interaction site; other site 573061002941 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573061002942 active site 573061002943 phosphorylation site [posttranslational modification] 573061002944 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 573061002945 beta-galactosidase; Region: BGL; TIGR03356 573061002946 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 573061002947 beta-galactosidase; Region: BGL; TIGR03356 573061002948 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 573061002949 beta-galactosidase; Region: BGL; TIGR03356 573061002950 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573061002951 DNA-binding site [nucleotide binding]; DNA binding site 573061002952 RNA-binding motif; other site 573061002953 prefoldin subunit beta; Provisional; Region: PRK09343 573061002954 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061002955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061002956 dimer interface [polypeptide binding]; other site 573061002957 putative CheW interface [polypeptide binding]; other site 573061002958 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573061002959 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573061002960 ATP binding site [chemical binding]; other site 573061002961 Mg++ binding site [ion binding]; other site 573061002962 motif III; other site 573061002963 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061002964 nucleotide binding region [chemical binding]; other site 573061002965 ATP-binding site [chemical binding]; other site 573061002966 hypothetical protein; Provisional; Region: PRK03881 573061002967 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 573061002968 AMMECR1; Region: AMMECR1; pfam01871 573061002969 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 573061002970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061002971 FeS/SAM binding site; other site 573061002972 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 573061002973 arsenical-resistance protein; Region: acr3; TIGR00832 573061002974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061002975 dimerization interface [polypeptide binding]; other site 573061002976 putative DNA binding site [nucleotide binding]; other site 573061002977 putative Zn2+ binding site [ion binding]; other site 573061002978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061002979 dimerization interface [polypeptide binding]; other site 573061002980 putative DNA binding site [nucleotide binding]; other site 573061002981 putative Zn2+ binding site [ion binding]; other site 573061002982 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061002983 metal-binding site [ion binding] 573061002984 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573061002985 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061002986 metal-binding site [ion binding] 573061002987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061002988 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573061002989 Helix-turn-helix domain; Region: HTH_36; pfam13730 573061002990 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573061002991 catalytic residues [active] 573061002992 Peptidase family U32; Region: Peptidase_U32; cl03113 573061002993 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573061002994 DNA methylase; Region: N6_N4_Mtase; pfam01555 573061002995 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 573061002996 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573061002997 dimer interface [polypeptide binding]; other site 573061002998 active site 573061002999 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573061003000 folate binding site [chemical binding]; other site 573061003001 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 573061003002 dimerization interface [polypeptide binding]; other site 573061003003 active site 573061003004 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573061003005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573061003006 active site 573061003007 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573061003008 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 573061003009 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573061003010 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573061003011 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573061003012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061003013 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061003014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061003015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061003016 Chloramphenicol acetyltransferase; Region: CAT; cl02008 573061003017 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 573061003018 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 573061003019 Predicted transcriptional regulator [Transcription]; Region: COG1959 573061003020 Transcriptional regulator; Region: Rrf2; pfam02082 573061003021 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061003022 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061003023 putative transposase OrfB; Reviewed; Region: PHA02517 573061003024 HTH-like domain; Region: HTH_21; pfam13276 573061003025 Integrase core domain; Region: rve; pfam00665 573061003026 Integrase core domain; Region: rve_3; pfam13683 573061003027 Homeodomain-like domain; Region: HTH_23; cl17451 573061003028 Transposase; Region: HTH_Tnp_1; cl17663 573061003029 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 573061003030 nucleotide binding site/active site [active] 573061003031 HIT family signature motif; other site 573061003032 catalytic residue [active] 573061003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061003034 Coenzyme A binding pocket [chemical binding]; other site 573061003035 AAA domain; Region: AAA_18; pfam13238 573061003036 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 573061003037 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573061003038 dimer interface [polypeptide binding]; other site 573061003039 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061003040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061003041 Coenzyme A binding pocket [chemical binding]; other site 573061003042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061003043 Coenzyme A binding pocket [chemical binding]; other site 573061003044 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573061003045 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573061003046 Metal-binding active site; metal-binding site 573061003047 Cadmium resistance transporter; Region: Cad; pfam03596 573061003048 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061003049 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061003050 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 573061003051 topology modulation protein; Reviewed; Region: PRK08118 573061003052 AAA domain; Region: AAA_17; pfam13207 573061003053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061003054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061003055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 573061003056 YCII-related domain; Region: YCII; cl00999 573061003057 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 573061003058 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 573061003059 NAD binding site [chemical binding]; other site 573061003060 sugar binding site [chemical binding]; other site 573061003061 divalent metal binding site [ion binding]; other site 573061003062 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061003063 dimer interface [polypeptide binding]; other site 573061003064 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573061003065 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573061003066 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 573061003067 active site 573061003068 catalytic site [active] 573061003069 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 573061003070 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061003071 Phospholipase B; Region: Phospholip_B; pfam04916 573061003072 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 573061003073 dimer interface [polypeptide binding]; other site 573061003074 catalytic triad [active] 573061003075 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 573061003076 Hemerythrin; Region: Hemerythrin; cd12107 573061003077 Fe binding site [ion binding]; other site 573061003078 putative transposase OrfB; Reviewed; Region: PHA02517 573061003079 HTH-like domain; Region: HTH_21; pfam13276 573061003080 Integrase core domain; Region: rve; pfam00665 573061003081 Integrase core domain; Region: rve_3; pfam13683 573061003082 Homeodomain-like domain; Region: HTH_23; cl17451 573061003083 Transposase; Region: HTH_Tnp_1; cl17663 573061003084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061003085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061003086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061003087 dimerization interface [polypeptide binding]; other site 573061003088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061003089 dimerization interface [polypeptide binding]; other site 573061003090 putative DNA binding site [nucleotide binding]; other site 573061003091 putative Zn2+ binding site [ion binding]; other site 573061003092 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 573061003093 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573061003094 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 573061003095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061003096 motif II; other site 573061003097 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573061003098 nudix motif; other site 573061003099 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573061003100 topology modulation protein; Reviewed; Region: PRK08118 573061003101 AAA domain; Region: AAA_17; pfam13207 573061003102 Response regulator receiver domain; Region: Response_reg; pfam00072 573061003103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061003104 active site 573061003105 phosphorylation site [posttranslational modification] 573061003106 intermolecular recognition site; other site 573061003107 dimerization interface [polypeptide binding]; other site 573061003108 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573061003109 MarR family; Region: MarR; pfam01047 573061003110 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573061003111 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573061003112 RNA polymerase factor sigma-70; Validated; Region: PRK06811 573061003113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061003114 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 573061003115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061003116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 573061003117 active site 573061003118 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573061003119 conserved cys residue [active] 573061003120 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 573061003121 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 573061003122 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 573061003123 active site 573061003124 catalytic site [active] 573061003125 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 573061003126 dimerization interface [polypeptide binding]; other site 573061003127 putative active cleft [active] 573061003128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061003129 binding surface 573061003130 TPR motif; other site 573061003131 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 573061003132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061003133 binding surface 573061003134 TPR repeat; Region: TPR_11; pfam13414 573061003135 TPR motif; other site 573061003136 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 573061003137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061003138 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573061003139 Walker A motif; other site 573061003140 ATP binding site [chemical binding]; other site 573061003141 ATP-binding site [chemical binding]; other site 573061003142 Walker B motif; other site 573061003143 arginine finger; other site 573061003144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061003145 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573061003146 active site 573061003147 HIGH motif; other site 573061003148 nucleotide binding site [chemical binding]; other site 573061003149 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573061003150 KMSKS motif; other site 573061003151 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573061003152 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 573061003153 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061003154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061003155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061003156 Walker A/P-loop; other site 573061003157 ATP binding site [chemical binding]; other site 573061003158 Q-loop/lid; other site 573061003159 ABC transporter signature motif; other site 573061003160 Walker B; other site 573061003161 D-loop; other site 573061003162 H-loop/switch region; other site 573061003163 hypothetical protein; Provisional; Region: PRK06851 573061003164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061003165 Walker A motif; other site 573061003166 ATP binding site [chemical binding]; other site 573061003167 NTPase; Region: NTPase_1; cl17478 573061003168 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 573061003169 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 573061003170 active site 573061003171 catalytic triad [active] 573061003172 oxyanion hole [active] 573061003173 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 573061003174 RNA polymerase factor sigma-70; Validated; Region: PRK06811 573061003175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061003176 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 573061003177 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 573061003178 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 573061003179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061003180 ATP binding site [chemical binding]; other site 573061003181 putative Mg++ binding site [ion binding]; other site 573061003182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061003183 nucleotide binding region [chemical binding]; other site 573061003184 ATP-binding site [chemical binding]; other site 573061003185 Fic family protein [Function unknown]; Region: COG3177 573061003186 Fic/DOC family; Region: Fic; pfam02661 573061003187 HsdM N-terminal domain; Region: HsdM_N; pfam12161 573061003188 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 573061003189 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573061003190 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 573061003191 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573061003192 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573061003193 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573061003194 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 573061003195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061003196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061003197 ATP binding site [chemical binding]; other site 573061003198 Mg2+ binding site [ion binding]; other site 573061003199 G-X-G motif; other site 573061003200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061003201 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061003202 Walker A/P-loop; other site 573061003203 ATP binding site [chemical binding]; other site 573061003204 Q-loop/lid; other site 573061003205 ABC transporter signature motif; other site 573061003206 Walker B; other site 573061003207 D-loop; other site 573061003208 H-loop/switch region; other site 573061003209 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061003210 FtsX-like permease family; Region: FtsX; pfam02687 573061003211 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573061003212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061003213 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573061003214 ATP binding site [chemical binding]; other site 573061003215 Mg2+ binding site [ion binding]; other site 573061003216 G-X-G motif; other site 573061003217 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061003219 active site 573061003220 phosphorylation site [posttranslational modification] 573061003221 intermolecular recognition site; other site 573061003222 dimerization interface [polypeptide binding]; other site 573061003223 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061003224 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573061003225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573061003226 Catalytic site [active] 573061003227 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061003228 ligand binding site [chemical binding]; other site 573061003229 calcium binding site [ion binding]; other site 573061003230 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061003231 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003232 Carbohydrate binding module 27; Region: CBM27; pfam09212 573061003233 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 573061003234 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 573061003235 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 573061003236 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 573061003237 dimer interface [polypeptide binding]; other site 573061003238 active site 573061003239 metal binding site [ion binding]; metal-binding site 573061003240 H+ Antiporter protein; Region: 2A0121; TIGR00900 573061003241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061003242 putative substrate translocation pore; other site 573061003243 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 573061003244 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 573061003245 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 573061003246 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 573061003247 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003248 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003249 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 573061003250 putative metal binding residues [ion binding]; other site 573061003251 signature motif; other site 573061003252 dimer interface [polypeptide binding]; other site 573061003253 active site 573061003254 polyP binding site; other site 573061003255 substrate binding site [chemical binding]; other site 573061003256 acceptor-phosphate pocket; other site 573061003257 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 573061003258 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573061003259 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 573061003260 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 573061003261 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061003262 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061003263 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003264 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061003266 dimerization interface [polypeptide binding]; other site 573061003267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061003268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061003269 dimer interface [polypeptide binding]; other site 573061003270 putative CheW interface [polypeptide binding]; other site 573061003271 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061003272 Interdomain contacts; other site 573061003273 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 573061003274 Cytokine receptor motif; other site 573061003275 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 573061003276 active site 573061003277 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 573061003278 substrate binding pocket [chemical binding]; other site 573061003279 aspartate-rich region 2; other site 573061003280 substrate-Mg2+ binding site; other site 573061003281 CAAX protease self-immunity; Region: Abi; pfam02517 573061003282 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 573061003283 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 573061003284 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 573061003285 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 573061003286 nickel binding site [ion binding]; other site 573061003287 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 573061003288 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061003289 HupF/HypC family; Region: HupF_HypC; pfam01455 573061003290 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 573061003291 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 573061003292 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 573061003293 dimerization interface [polypeptide binding]; other site 573061003294 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 573061003295 ATP binding site [chemical binding]; other site 573061003296 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061003297 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003298 ligand binding site [chemical binding]; other site 573061003299 calcium binding site [ion binding]; other site 573061003300 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061003301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061003302 dimer interface [polypeptide binding]; other site 573061003303 putative CheW interface [polypeptide binding]; other site 573061003304 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573061003305 C-terminal peptidase (prc); Region: prc; TIGR00225 573061003306 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573061003307 protein binding site [polypeptide binding]; other site 573061003308 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573061003309 Catalytic dyad [active] 573061003310 MAEBL; Provisional; Region: PTZ00121 573061003311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061003312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061003313 active site 573061003314 phosphorylation site [posttranslational modification] 573061003315 intermolecular recognition site; other site 573061003316 dimerization interface [polypeptide binding]; other site 573061003317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061003318 DNA binding site [nucleotide binding] 573061003319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061003320 HAMP domain; Region: HAMP; pfam00672 573061003321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061003322 dimer interface [polypeptide binding]; other site 573061003323 phosphorylation site [posttranslational modification] 573061003324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061003325 ATP binding site [chemical binding]; other site 573061003326 Mg2+ binding site [ion binding]; other site 573061003327 G-X-G motif; other site 573061003328 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061003329 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061003330 Walker A/P-loop; other site 573061003331 ATP binding site [chemical binding]; other site 573061003332 Q-loop/lid; other site 573061003333 ABC transporter signature motif; other site 573061003334 Walker B; other site 573061003335 D-loop; other site 573061003336 H-loop/switch region; other site 573061003337 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061003338 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061003339 FtsX-like permease family; Region: FtsX; pfam02687 573061003340 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061003341 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061003342 FtsX-like permease family; Region: FtsX; pfam02687 573061003343 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 573061003344 Cadmium resistance transporter; Region: Cad; pfam03596 573061003345 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 573061003346 Amb_all domain; Region: Amb_all; smart00656 573061003347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061003348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061003349 DNA binding site [nucleotide binding] 573061003350 domain linker motif; other site 573061003351 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573061003352 dimerization interface [polypeptide binding]; other site 573061003353 ligand binding site [chemical binding]; other site 573061003354 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 573061003355 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003356 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 573061003357 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003358 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573061003359 Pyruvate formate lyase; Region: PFL; pfam02901 573061003360 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 573061003361 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 573061003362 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061003363 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857 573061003364 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 573061003365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061003366 active site 573061003367 phosphorylation site [posttranslational modification] 573061003368 intermolecular recognition site; other site 573061003369 dimerization interface [polypeptide binding]; other site 573061003370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 573061003371 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061003372 dockerin binding interface; other site 573061003373 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003374 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061003375 dockerin binding interface; other site 573061003376 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003377 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061003378 dockerin binding interface; other site 573061003379 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061003380 Interdomain contacts; other site 573061003381 Cytokine receptor motif; other site 573061003382 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061003383 Interdomain contacts; other site 573061003384 Cytokine receptor motif; other site 573061003385 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 573061003386 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 573061003387 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573061003388 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573061003389 Walker A/P-loop; other site 573061003390 ATP binding site [chemical binding]; other site 573061003391 Q-loop/lid; other site 573061003392 ABC transporter signature motif; other site 573061003393 Walker B; other site 573061003394 D-loop; other site 573061003395 H-loop/switch region; other site 573061003396 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573061003397 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573061003398 Walker A/P-loop; other site 573061003399 ATP binding site [chemical binding]; other site 573061003400 Q-loop/lid; other site 573061003401 ABC transporter signature motif; other site 573061003402 Walker B; other site 573061003403 D-loop; other site 573061003404 H-loop/switch region; other site 573061003405 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573061003406 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061003407 TM-ABC transporter signature motif; other site 573061003408 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061003409 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573061003410 TM-ABC transporter signature motif; other site 573061003411 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573061003412 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 573061003413 putative ligand binding site [chemical binding]; other site 573061003414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061003415 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573061003416 Walker A/P-loop; other site 573061003417 ATP binding site [chemical binding]; other site 573061003418 Q-loop/lid; other site 573061003419 ABC transporter signature motif; other site 573061003420 Walker B; other site 573061003421 D-loop; other site 573061003422 H-loop/switch region; other site 573061003423 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 573061003424 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 573061003425 Walker A/P-loop; other site 573061003426 ATP binding site [chemical binding]; other site 573061003427 Q-loop/lid; other site 573061003428 ABC transporter signature motif; other site 573061003429 Walker B; other site 573061003430 D-loop; other site 573061003431 H-loop/switch region; other site 573061003432 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 573061003433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573061003434 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 573061003435 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573061003436 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061003437 Family of unknown function (DUF438); Region: DUF438; pfam04282 573061003438 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 573061003439 Fe binding site [ion binding]; other site 573061003440 hybrid cluster protein; Provisional; Region: PRK05290 573061003441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061003442 ACS interaction site; other site 573061003443 CODH interaction site; other site 573061003444 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 573061003445 hybrid metal cluster; other site 573061003446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061003447 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061003448 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573061003449 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573061003450 ligand binding site [chemical binding]; other site 573061003451 flexible hinge region; other site 573061003452 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573061003453 putative switch regulator; other site 573061003454 non-specific DNA interactions [nucleotide binding]; other site 573061003455 DNA binding site [nucleotide binding] 573061003456 sequence specific DNA binding site [nucleotide binding]; other site 573061003457 putative cAMP binding site [chemical binding]; other site 573061003458 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 573061003459 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573061003460 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061003461 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061003462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061003463 dimerization interface [polypeptide binding]; other site 573061003464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061003465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061003466 dimer interface [polypeptide binding]; other site 573061003467 putative CheW interface [polypeptide binding]; other site 573061003468 QueT transporter; Region: QueT; pfam06177 573061003469 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 573061003470 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 573061003471 Ligand Binding Site [chemical binding]; other site 573061003472 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061003473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061003474 dimer interface [polypeptide binding]; other site 573061003475 putative CheW interface [polypeptide binding]; other site 573061003476 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573061003477 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003478 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061003479 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061003480 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003481 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573061003482 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003483 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061003484 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003485 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061003486 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003487 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061003488 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003489 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061003490 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 573061003491 putative FMN binding site [chemical binding]; other site 573061003492 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 573061003493 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573061003494 GIY-YIG motif/motif A; other site 573061003495 active site 573061003496 catalytic site [active] 573061003497 putative DNA binding site [nucleotide binding]; other site 573061003498 metal binding site [ion binding]; metal-binding site 573061003499 UvrB/uvrC motif; Region: UVR; pfam02151 573061003500 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 573061003501 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573061003502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061003503 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573061003504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061003505 DNA-binding site [nucleotide binding]; DNA binding site 573061003506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061003507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061003508 homodimer interface [polypeptide binding]; other site 573061003509 catalytic residue [active] 573061003510 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 573061003511 putative active site [active] 573061003512 putative metal binding site [ion binding]; other site 573061003513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061003514 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061003515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061003516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061003517 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061003518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061003519 substrate binding pocket [chemical binding]; other site 573061003520 membrane-bound complex binding site; other site 573061003521 hinge residues; other site 573061003522 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061003523 active site 573061003524 catalytic triad [active] 573061003525 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061003526 active site 573061003527 catalytic triad [active] 573061003528 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061003529 active site 573061003530 catalytic triad [active] 573061003531 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061003532 active site 573061003533 catalytic triad [active] 573061003534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061003535 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061003536 substrate binding pocket [chemical binding]; other site 573061003537 membrane-bound complex binding site; other site 573061003538 hinge residues; other site 573061003539 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061003540 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003541 ligand binding site [chemical binding]; other site 573061003542 calcium binding site [ion binding]; other site 573061003543 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061003544 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003545 ligand binding site [chemical binding]; other site 573061003546 calcium binding site [ion binding]; other site 573061003547 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061003548 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003549 ligand binding site [chemical binding]; other site 573061003550 calcium binding site [ion binding]; other site 573061003551 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573061003552 amidase catalytic site [active] 573061003553 Zn binding residues [ion binding]; other site 573061003554 substrate binding site [chemical binding]; other site 573061003555 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 573061003556 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 573061003557 Accessory gene regulator B; Region: AgrB; pfam04647 573061003558 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061003559 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061003560 BioY family; Region: BioY; pfam02632 573061003561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061003562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061003563 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061003564 Walker A/P-loop; other site 573061003565 ATP binding site [chemical binding]; other site 573061003566 Q-loop/lid; other site 573061003567 ABC transporter signature motif; other site 573061003568 Walker B; other site 573061003569 D-loop; other site 573061003570 H-loop/switch region; other site 573061003571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061003572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061003573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061003574 Walker A/P-loop; other site 573061003575 ATP binding site [chemical binding]; other site 573061003576 Q-loop/lid; other site 573061003577 ABC transporter signature motif; other site 573061003578 Walker B; other site 573061003579 D-loop; other site 573061003580 H-loop/switch region; other site 573061003581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061003582 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573061003583 active site 573061003584 motif I; other site 573061003585 motif II; other site 573061003586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061003587 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 573061003588 active site 573061003589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061003590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061003591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573061003592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061003593 putative PBP binding loops; other site 573061003594 dimer interface [polypeptide binding]; other site 573061003595 ABC-ATPase subunit interface; other site 573061003596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061003597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061003598 dimer interface [polypeptide binding]; other site 573061003599 conserved gate region; other site 573061003600 putative PBP binding loops; other site 573061003601 ABC-ATPase subunit interface; other site 573061003602 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 573061003603 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 573061003604 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 573061003605 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 573061003606 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 573061003607 B12 binding site [chemical binding]; other site 573061003608 cobalt ligand [ion binding]; other site 573061003609 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 573061003610 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573061003611 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 573061003612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573061003613 catalytic loop [active] 573061003614 iron binding site [ion binding]; other site 573061003615 Predicted transcriptional regulator [Transcription]; Region: COG4189 573061003616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061003617 dimerization interface [polypeptide binding]; other site 573061003618 putative DNA binding site [nucleotide binding]; other site 573061003619 putative Zn2+ binding site [ion binding]; other site 573061003620 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573061003621 active site 573061003622 catalytic residues [active] 573061003623 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573061003624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061003625 DNA-binding site [nucleotide binding]; DNA binding site 573061003626 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061003627 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061003628 L-arabinose isomerase; Provisional; Region: PRK02929 573061003629 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 573061003630 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573061003631 trimer interface [polypeptide binding]; other site 573061003632 substrate binding site [chemical binding]; other site 573061003633 Mn binding site [ion binding]; other site 573061003634 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573061003635 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573061003636 intersubunit interface [polypeptide binding]; other site 573061003637 active site 573061003638 Zn2+ binding site [ion binding]; other site 573061003639 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 573061003640 active site 573061003641 intersubunit interactions; other site 573061003642 catalytic residue [active] 573061003643 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573061003644 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573061003645 TPP-binding site [chemical binding]; other site 573061003646 dimer interface [polypeptide binding]; other site 573061003647 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573061003648 PYR/PP interface [polypeptide binding]; other site 573061003649 dimer interface [polypeptide binding]; other site 573061003650 TPP binding site [chemical binding]; other site 573061003651 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573061003652 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 573061003653 dimanganese center [ion binding]; other site 573061003654 CotJB protein; Region: CotJB; pfam12652 573061003655 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 573061003656 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 573061003657 alanine racemase; Reviewed; Region: alr; PRK00053 573061003658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573061003659 active site 573061003660 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573061003661 dimer interface [polypeptide binding]; other site 573061003662 substrate binding site [chemical binding]; other site 573061003663 catalytic residues [active] 573061003664 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 573061003665 PemK-like protein; Region: PemK; pfam02452 573061003666 transketolase; Reviewed; Region: PRK05899 573061003667 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573061003668 TPP-binding site [chemical binding]; other site 573061003669 dimer interface [polypeptide binding]; other site 573061003670 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 573061003671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573061003672 PYR/PP interface [polypeptide binding]; other site 573061003673 dimer interface [polypeptide binding]; other site 573061003674 TPP binding site [chemical binding]; other site 573061003675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573061003676 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573061003677 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061003678 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573061003679 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 573061003680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061003681 Walker A/P-loop; other site 573061003682 ATP binding site [chemical binding]; other site 573061003683 Q-loop/lid; other site 573061003684 ABC transporter signature motif; other site 573061003685 Walker B; other site 573061003686 D-loop; other site 573061003687 H-loop/switch region; other site 573061003688 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 573061003689 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 573061003690 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061003691 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573061003692 C-terminal peptidase (prc); Region: prc; TIGR00225 573061003693 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573061003694 protein binding site [polypeptide binding]; other site 573061003695 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573061003696 Catalytic dyad [active] 573061003697 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573061003698 GrpE; Region: GrpE; pfam01025 573061003699 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 573061003700 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 573061003701 nucleotide binding site [chemical binding]; other site 573061003702 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573061003703 SBD interface [polypeptide binding]; other site 573061003704 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 573061003705 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 573061003706 nucleotide binding site [chemical binding]; other site 573061003707 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573061003708 SBD interface [polypeptide binding]; other site 573061003709 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 573061003710 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573061003711 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573061003712 shikimate binding site; other site 573061003713 NAD(P) binding site [chemical binding]; other site 573061003714 methionine aminopeptidase; Provisional; Region: PRK12318 573061003715 SEC-C motif; Region: SEC-C; pfam02810 573061003716 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573061003717 active site 573061003718 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 573061003719 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 573061003720 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 573061003721 putative metal binding site [ion binding]; other site 573061003722 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 573061003723 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 573061003724 putative sugar binding sites [chemical binding]; other site 573061003725 Q-X-W motif; other site 573061003726 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003727 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061003728 glutamate dehydrogenase; Provisional; Region: PRK09414 573061003729 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573061003730 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 573061003731 NAD(P) binding site [chemical binding]; other site 573061003732 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573061003733 homodimer interface [polypeptide binding]; other site 573061003734 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573061003735 active site pocket [active] 573061003736 EDD domain protein, DegV family; Region: DegV; TIGR00762 573061003737 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 573061003738 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 573061003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061003740 Coenzyme A binding pocket [chemical binding]; other site 573061003741 AAA ATPase domain; Region: AAA_16; pfam13191 573061003742 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 573061003743 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573061003744 Substrate binding site; other site 573061003745 Cupin domain; Region: Cupin_2; cl17218 573061003746 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 573061003747 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 573061003748 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573061003749 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 573061003750 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 573061003751 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573061003752 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 573061003753 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061003754 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 573061003755 Chain length determinant protein; Region: Wzz; cl15801 573061003756 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 573061003757 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573061003758 dimerization interface 3.5A [polypeptide binding]; other site 573061003759 active site 573061003760 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 573061003761 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573061003762 Hemerythrin-like domain; Region: Hr-like; cd12108 573061003763 Fe binding site [ion binding]; other site 573061003764 Transcriptional regulator [Transcription]; Region: LytR; COG1316 573061003765 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 573061003766 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573061003767 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061003768 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061003769 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 573061003770 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 573061003771 generic binding surface II; other site 573061003772 generic binding surface I; other site 573061003773 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061003774 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573061003775 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061003776 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061003777 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573061003778 argininosuccinate synthase; Provisional; Region: PRK13820 573061003779 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573061003780 ANP binding site [chemical binding]; other site 573061003781 Substrate Binding Site II [chemical binding]; other site 573061003782 Substrate Binding Site I [chemical binding]; other site 573061003783 argininosuccinate lyase; Provisional; Region: PRK00855 573061003784 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573061003785 active sites [active] 573061003786 tetramer interface [polypeptide binding]; other site 573061003787 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 573061003788 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 573061003789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061003790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061003791 active site 573061003792 phosphorylation site [posttranslational modification] 573061003793 intermolecular recognition site; other site 573061003794 dimerization interface [polypeptide binding]; other site 573061003795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061003796 DNA binding site [nucleotide binding] 573061003797 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 573061003798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061003799 dimerization interface [polypeptide binding]; other site 573061003800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061003801 dimer interface [polypeptide binding]; other site 573061003802 phosphorylation site [posttranslational modification] 573061003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061003804 ATP binding site [chemical binding]; other site 573061003805 Mg2+ binding site [ion binding]; other site 573061003806 G-X-G motif; other site 573061003807 Accessory gene regulator B; Region: AgrB; pfam04647 573061003808 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 573061003809 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573061003810 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573061003811 putative valine binding site [chemical binding]; other site 573061003812 dimer interface [polypeptide binding]; other site 573061003813 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573061003814 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 573061003815 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 573061003816 active site 573061003817 catalytic residues [active] 573061003818 metal binding site [ion binding]; metal-binding site 573061003819 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573061003820 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573061003821 tartrate dehydrogenase; Region: TTC; TIGR02089 573061003822 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 573061003823 6-phosphogluconate dehydratase; Region: edd; TIGR01196 573061003824 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 573061003825 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573061003826 PYR/PP interface [polypeptide binding]; other site 573061003827 dimer interface [polypeptide binding]; other site 573061003828 TPP binding site [chemical binding]; other site 573061003829 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573061003830 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573061003831 TPP-binding site [chemical binding]; other site 573061003832 dimer interface [polypeptide binding]; other site 573061003833 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573061003834 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573061003835 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573061003836 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573061003837 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573061003838 homodimer interface [polypeptide binding]; other site 573061003839 substrate-cofactor binding pocket; other site 573061003840 catalytic residue [active] 573061003841 SWIM zinc finger; Region: SWIM; pfam04434 573061003842 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 573061003843 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 573061003844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061003845 ATP binding site [chemical binding]; other site 573061003846 putative Mg++ binding site [ion binding]; other site 573061003847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061003848 nucleotide binding region [chemical binding]; other site 573061003849 ATP-binding site [chemical binding]; other site 573061003850 MgtE intracellular N domain; Region: MgtE_N; smart00924 573061003851 FOG: CBS domain [General function prediction only]; Region: COG0517 573061003852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 573061003853 serine O-acetyltransferase; Region: cysE; TIGR01172 573061003854 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573061003855 trimer interface [polypeptide binding]; other site 573061003856 active site 573061003857 substrate binding site [chemical binding]; other site 573061003858 CoA binding site [chemical binding]; other site 573061003859 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 573061003860 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 573061003861 4Fe-4S binding domain; Region: Fer4; pfam00037 573061003862 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573061003863 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573061003864 putative acyl-acceptor binding pocket; other site 573061003865 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573061003866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573061003867 minor groove reading motif; other site 573061003868 helix-hairpin-helix signature motif; other site 573061003869 substrate binding pocket [chemical binding]; other site 573061003870 active site 573061003871 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 573061003872 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 573061003873 homodimer interface [polypeptide binding]; other site 573061003874 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573061003875 active site 573061003876 catalytic site [active] 573061003877 maltose binding site 2 [chemical binding]; other site 573061003878 Rubrerythrin [Energy production and conversion]; Region: COG1592 573061003879 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573061003880 binuclear metal center [ion binding]; other site 573061003881 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573061003882 iron binding site [ion binding]; other site 573061003883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573061003884 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 573061003885 putative lipid kinase; Reviewed; Region: PRK13059 573061003886 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573061003887 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 573061003888 hypothetical protein; Provisional; Region: PRK00955 573061003889 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 573061003890 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 573061003891 beta-galactosidase; Region: BGL; TIGR03356 573061003892 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061003893 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573061003894 Double zinc ribbon; Region: DZR; pfam12773 573061003895 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573061003896 ZIP Zinc transporter; Region: Zip; pfam02535 573061003897 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 573061003898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061003899 Walker A/P-loop; other site 573061003900 ATP binding site [chemical binding]; other site 573061003901 Q-loop/lid; other site 573061003902 ABC transporter signature motif; other site 573061003903 Walker B; other site 573061003904 D-loop; other site 573061003905 H-loop/switch region; other site 573061003906 Flavodoxin domain; Region: Flavodoxin_5; cl17428 573061003907 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573061003908 Predicted acetyltransferase [General function prediction only]; Region: COG2388 573061003909 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 573061003910 active site 573061003911 DNA binding site [nucleotide binding] 573061003912 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 573061003913 Sulfatase; Region: Sulfatase; pfam00884 573061003914 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573061003915 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573061003916 ATP binding site [chemical binding]; other site 573061003917 Mg++ binding site [ion binding]; other site 573061003918 motif III; other site 573061003919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061003920 nucleotide binding region [chemical binding]; other site 573061003921 ATP-binding site [chemical binding]; other site 573061003922 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 573061003923 RNA binding site [nucleotide binding]; other site 573061003924 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573061003925 Rubredoxin; Region: Rubredoxin; pfam00301 573061003926 iron binding site [ion binding]; other site 573061003927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 573061003928 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573061003929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061003930 dimer interface [polypeptide binding]; other site 573061003931 conserved gate region; other site 573061003932 putative PBP binding loops; other site 573061003933 ABC-ATPase subunit interface; other site 573061003934 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573061003935 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573061003936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061003937 dimer interface [polypeptide binding]; other site 573061003938 conserved gate region; other site 573061003939 putative PBP binding loops; other site 573061003940 ABC-ATPase subunit interface; other site 573061003941 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573061003942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573061003943 Walker A/P-loop; other site 573061003944 ATP binding site [chemical binding]; other site 573061003945 Q-loop/lid; other site 573061003946 ABC transporter signature motif; other site 573061003947 Walker B; other site 573061003948 D-loop; other site 573061003949 H-loop/switch region; other site 573061003950 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573061003951 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 573061003952 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573061003953 Walker A/P-loop; other site 573061003954 ATP binding site [chemical binding]; other site 573061003955 Q-loop/lid; other site 573061003956 ABC transporter signature motif; other site 573061003957 Walker B; other site 573061003958 D-loop; other site 573061003959 H-loop/switch region; other site 573061003960 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573061003961 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 573061003962 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 573061003963 peptide binding site [polypeptide binding]; other site 573061003964 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 573061003965 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 573061003966 active site 573061003967 metal binding site [ion binding]; metal-binding site 573061003968 DNA binding site [nucleotide binding] 573061003969 Uncharacterized conserved protein [Function unknown]; Region: COG4717 573061003970 V-type ATP synthase subunit I; Validated; Region: PRK05771 573061003971 Uncharacterized conserved protein [Function unknown]; Region: COG4717 573061003972 AAA domain; Region: AAA_33; pfam13671 573061003973 AAA domain; Region: AAA_17; pfam13207 573061003974 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573061003975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573061003976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573061003977 ligand binding site [chemical binding]; other site 573061003978 flexible hinge region; other site 573061003979 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573061003980 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 573061003981 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573061003982 active site 573061003983 dimer interface [polypeptide binding]; other site 573061003984 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573061003985 dimer interface [polypeptide binding]; other site 573061003986 active site 573061003987 hypothetical protein; Validated; Region: PRK00124 573061003988 pullulanase, type I; Region: pulA_typeI; TIGR02104 573061003989 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 573061003990 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 573061003991 Ca binding site [ion binding]; other site 573061003992 active site 573061003993 catalytic site [active] 573061003994 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 573061003995 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061003996 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061003997 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061003998 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061003999 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061004000 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573061004001 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573061004002 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573061004003 catalytic residue [active] 573061004004 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573061004005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061004006 RNA binding surface [nucleotide binding]; other site 573061004007 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 573061004008 active site 573061004009 uracil binding [chemical binding]; other site 573061004010 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 573061004011 Part of AAA domain; Region: AAA_19; pfam13245 573061004012 AAA domain; Region: AAA_14; pfam13173 573061004013 Family description; Region: UvrD_C_2; pfam13538 573061004014 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 573061004015 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573061004016 nucleotide binding pocket [chemical binding]; other site 573061004017 K-X-D-G motif; other site 573061004018 catalytic site [active] 573061004019 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573061004020 Helix-hairpin-helix motif; Region: HHH; pfam00633 573061004021 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573061004022 Dimer interface [polypeptide binding]; other site 573061004023 BRCT sequence motif; other site 573061004024 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 573061004025 Uncharacterized conserved protein [Function unknown]; Region: COG3379 573061004026 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 573061004027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061004028 putative substrate translocation pore; other site 573061004029 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 573061004030 dimerization interface [polypeptide binding]; other site 573061004031 putative ATP binding site [chemical binding]; other site 573061004032 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573061004033 active site 573061004034 dimerization interface [polypeptide binding]; other site 573061004035 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 573061004036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061004037 active site 573061004038 metal binding site [ion binding]; metal-binding site 573061004039 homotetramer interface [polypeptide binding]; other site 573061004040 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061004041 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573061004042 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061004043 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061004044 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 573061004045 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573061004046 Yqey-like protein; Region: YqeY; cl17540 573061004047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061004048 active site 573061004049 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573061004050 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 573061004051 putative ligand binding site [chemical binding]; other site 573061004052 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573061004053 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573061004054 Walker A/P-loop; other site 573061004055 ATP binding site [chemical binding]; other site 573061004056 Q-loop/lid; other site 573061004057 ABC transporter signature motif; other site 573061004058 Walker B; other site 573061004059 D-loop; other site 573061004060 H-loop/switch region; other site 573061004061 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573061004062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061004063 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573061004064 TM-ABC transporter signature motif; other site 573061004065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061004066 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573061004067 TM-ABC transporter signature motif; other site 573061004068 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573061004069 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 573061004070 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573061004071 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 573061004072 Tubby C 2; Region: Tub_2; cl02043 573061004073 SLBB domain; Region: SLBB; pfam10531 573061004074 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 573061004075 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 573061004076 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573061004077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061004078 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061004079 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573061004080 Competence protein; Region: Competence; pfam03772 573061004081 TPR repeat; Region: TPR_11; pfam13414 573061004082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061004083 binding surface 573061004084 TPR motif; other site 573061004085 TPR repeat; Region: TPR_11; pfam13414 573061004086 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573061004087 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061004088 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 573061004089 putative active site [active] 573061004090 putative metal binding site [ion binding]; other site 573061004091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061004092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061004093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061004094 dimerization interface [polypeptide binding]; other site 573061004095 putative hydratase; Provisional; Region: PRK11413 573061004096 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 573061004097 substrate binding site [chemical binding]; other site 573061004098 ligand binding site [chemical binding]; other site 573061004099 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 573061004100 substrate binding site [chemical binding]; other site 573061004101 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573061004102 transcription elongation factor GreA; Region: greA; TIGR01462 573061004103 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573061004104 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 573061004105 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573061004106 AAA domain; Region: AAA_18; pfam13238 573061004107 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573061004108 germination protease; Provisional; Region: PRK12362 573061004109 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 573061004110 stage II sporulation protein P; Region: spore_II_P; TIGR02867 573061004111 GTP-binding protein LepA; Provisional; Region: PRK05433 573061004112 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573061004113 G1 box; other site 573061004114 putative GEF interaction site [polypeptide binding]; other site 573061004115 GTP/Mg2+ binding site [chemical binding]; other site 573061004116 Switch I region; other site 573061004117 G2 box; other site 573061004118 G3 box; other site 573061004119 Switch II region; other site 573061004120 G4 box; other site 573061004121 G5 box; other site 573061004122 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573061004123 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573061004124 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573061004125 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 573061004126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061004127 FeS/SAM binding site; other site 573061004128 HemN C-terminal domain; Region: HemN_C; pfam06969 573061004129 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 573061004130 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573061004131 GrpE; Region: GrpE; pfam01025 573061004132 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573061004133 dimer interface [polypeptide binding]; other site 573061004134 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573061004135 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573061004136 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 573061004137 nucleotide binding site [chemical binding]; other site 573061004138 NEF interaction site [polypeptide binding]; other site 573061004139 SBD interface [polypeptide binding]; other site 573061004140 chaperone protein DnaJ; Provisional; Region: PRK14297 573061004141 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573061004142 HSP70 interaction site [polypeptide binding]; other site 573061004143 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573061004144 substrate binding site [polypeptide binding]; other site 573061004145 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573061004146 Zn binding sites [ion binding]; other site 573061004147 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573061004148 dimer interface [polypeptide binding]; other site 573061004149 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 573061004150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061004151 S-adenosylmethionine binding site [chemical binding]; other site 573061004152 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573061004153 RNA methyltransferase, RsmE family; Region: TIGR00046 573061004154 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061004155 endoglucanase; Region: PLN02308 573061004156 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061004157 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 573061004158 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061004159 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061004160 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573061004161 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573061004162 Pectinesterase; Region: Pectinesterase; pfam01095 573061004163 putative pectinesterase; Region: PLN02432; cl01911 573061004164 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061004165 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061004166 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061004167 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061004168 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061004169 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061004170 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061004171 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004172 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061004173 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061004174 putative active site [active] 573061004175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061004176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061004177 Walker A/P-loop; other site 573061004178 ATP binding site [chemical binding]; other site 573061004179 Q-loop/lid; other site 573061004180 ABC transporter signature motif; other site 573061004181 Walker B; other site 573061004182 D-loop; other site 573061004183 H-loop/switch region; other site 573061004184 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573061004185 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573061004186 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061004187 putative alpha-glucosidase; Provisional; Region: PRK10658 573061004188 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573061004189 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 573061004190 active site 573061004191 homotrimer interface [polypeptide binding]; other site 573061004192 catalytic site [active] 573061004193 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 573061004194 Cupin domain; Region: Cupin_2; cl17218 573061004195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061004196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061004197 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 573061004198 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061004199 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004200 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004201 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 573061004202 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 573061004203 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 573061004204 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573061004205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061004206 FeS/SAM binding site; other site 573061004207 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 573061004208 nucleotide binding site/active site [active] 573061004209 HIT family signature motif; other site 573061004210 catalytic residue [active] 573061004211 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573061004212 YabP family; Region: YabP; cl06766 573061004213 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 573061004214 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 573061004215 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 573061004216 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 573061004217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061004218 Zn2+ binding site [ion binding]; other site 573061004219 Mg2+ binding site [ion binding]; other site 573061004220 metal-binding heat shock protein; Provisional; Region: PRK00016 573061004221 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 573061004222 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 573061004223 active site 573061004224 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573061004225 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573061004226 active site 573061004227 catalytic motif [active] 573061004228 Zn binding site [ion binding]; other site 573061004229 GTPase Era; Reviewed; Region: era; PRK00089 573061004230 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573061004231 G1 box; other site 573061004232 GTP/Mg2+ binding site [chemical binding]; other site 573061004233 Switch I region; other site 573061004234 G2 box; other site 573061004235 Switch II region; other site 573061004236 G3 box; other site 573061004237 G4 box; other site 573061004238 G5 box; other site 573061004239 KH domain; Region: KH_2; pfam07650 573061004240 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573061004241 Recombination protein O N terminal; Region: RecO_N; pfam11967 573061004242 Recombination protein O C terminal; Region: RecO_C; pfam02565 573061004243 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 573061004244 HTH domain; Region: HTH_11; pfam08279 573061004245 FOG: CBS domain [General function prediction only]; Region: COG0517 573061004246 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573061004247 pyruvate phosphate dikinase; Provisional; Region: PRK09279 573061004248 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573061004249 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573061004250 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573061004251 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 573061004252 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061004253 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061004254 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 573061004255 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 573061004256 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061004257 Phosphotransferase enzyme family; Region: APH; pfam01636 573061004258 active site 573061004259 ATP binding site [chemical binding]; other site 573061004260 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061004261 substrate binding site [chemical binding]; other site 573061004262 DNA primase; Validated; Region: dnaG; PRK05667 573061004263 CHC2 zinc finger; Region: zf-CHC2; pfam01807 573061004264 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573061004265 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573061004266 active site 573061004267 metal binding site [ion binding]; metal-binding site 573061004268 interdomain interaction site; other site 573061004269 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 573061004270 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 573061004271 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573061004272 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573061004273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061004274 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573061004275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061004276 DNA binding residues [nucleotide binding] 573061004277 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 573061004278 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 573061004279 Family of unknown function (DUF633); Region: DUF633; pfam04816 573061004280 Uncharacterized conserved protein [Function unknown]; Region: COG0327 573061004281 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 573061004282 Putative zinc ribbon domain; Region: DUF164; pfam02591 573061004283 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 573061004284 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061004285 active site 573061004286 metal binding site [ion binding]; metal-binding site 573061004287 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061004288 K+ potassium transporter; Region: K_trans; pfam02705 573061004289 Putative motility protein; Region: YjfB_motility; pfam14070 573061004290 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061004291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573061004292 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573061004293 active site 573061004294 catalytic tetrad [active] 573061004295 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061004296 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 573061004297 DNA binding residues [nucleotide binding] 573061004298 putative dimer interface [polypeptide binding]; other site 573061004299 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573061004300 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 573061004301 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 573061004302 active site 573061004303 catalytic site [active] 573061004304 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 573061004305 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573061004306 putative substrate binding site [chemical binding]; other site 573061004307 putative ATP binding site [chemical binding]; other site 573061004308 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 573061004309 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 573061004310 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061004311 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061004312 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061004313 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061004314 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061004315 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061004316 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061004317 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061004318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061004319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061004320 active site 573061004321 phosphorylation site [posttranslational modification] 573061004322 intermolecular recognition site; other site 573061004323 dimerization interface [polypeptide binding]; other site 573061004324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061004325 DNA binding site [nucleotide binding] 573061004326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061004327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061004328 dimer interface [polypeptide binding]; other site 573061004329 phosphorylation site [posttranslational modification] 573061004330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061004331 ATP binding site [chemical binding]; other site 573061004332 Mg2+ binding site [ion binding]; other site 573061004333 G-X-G motif; other site 573061004334 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 573061004335 putative metal binding residues [ion binding]; other site 573061004336 signature motif; other site 573061004337 dimer interface [polypeptide binding]; other site 573061004338 active site 573061004339 polyP binding site; other site 573061004340 substrate binding site [chemical binding]; other site 573061004341 acceptor-phosphate pocket; other site 573061004342 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 573061004343 CotH protein; Region: CotH; pfam08757 573061004344 Chromate transporter; Region: Chromate_transp; pfam02417 573061004345 Chromate transporter; Region: Chromate_transp; pfam02417 573061004346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061004347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061004348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061004349 dimerization interface [polypeptide binding]; other site 573061004350 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573061004351 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 573061004352 active site 573061004353 FMN binding site [chemical binding]; other site 573061004354 substrate binding site [chemical binding]; other site 573061004355 putative catalytic residue [active] 573061004356 AzlC protein; Region: AzlC; cl00570 573061004357 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 573061004358 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573061004359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061004360 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 573061004361 diiron binding motif [ion binding]; other site 573061004362 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 573061004363 Predicted membrane protein [Function unknown]; Region: COG1971 573061004364 Domain of unknown function DUF; Region: DUF204; pfam02659 573061004365 Domain of unknown function DUF; Region: DUF204; pfam02659 573061004366 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573061004367 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573061004368 Metal-binding active site; metal-binding site 573061004369 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573061004370 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061004371 DNA binding residues [nucleotide binding] 573061004372 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061004373 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061004374 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061004375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061004376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061004377 L-fucose isomerase; Provisional; Region: fucI; PRK10991 573061004378 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 573061004379 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573061004380 trimer interface [polypeptide binding]; other site 573061004381 substrate binding site [chemical binding]; other site 573061004382 Mn binding site [ion binding]; other site 573061004383 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 573061004384 N- and C-terminal domain interface [polypeptide binding]; other site 573061004385 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 573061004386 active site 573061004387 putative catalytic site [active] 573061004388 metal binding site [ion binding]; metal-binding site 573061004389 ATP binding site [chemical binding]; other site 573061004390 carbohydrate binding site [chemical binding]; other site 573061004391 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 573061004392 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 573061004393 intersubunit interface [polypeptide binding]; other site 573061004394 active site 573061004395 Zn2+ binding site [ion binding]; other site 573061004396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061004397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061004398 active site 573061004399 phosphorylation site [posttranslational modification] 573061004400 intermolecular recognition site; other site 573061004401 dimerization interface [polypeptide binding]; other site 573061004402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061004403 DNA binding residues [nucleotide binding] 573061004404 dimerization interface [polypeptide binding]; other site 573061004405 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 573061004406 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 573061004407 dimer interface [polypeptide binding]; other site 573061004408 active site 573061004409 metal binding site [ion binding]; metal-binding site 573061004410 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 573061004411 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061004412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061004414 active site 573061004415 phosphorylation site [posttranslational modification] 573061004416 intermolecular recognition site; other site 573061004417 dimerization interface [polypeptide binding]; other site 573061004418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061004419 DNA binding site [nucleotide binding] 573061004420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061004421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573061004422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061004423 dimer interface [polypeptide binding]; other site 573061004424 phosphorylation site [posttranslational modification] 573061004425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061004426 ATP binding site [chemical binding]; other site 573061004427 Mg2+ binding site [ion binding]; other site 573061004428 G-X-G motif; other site 573061004429 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061004430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061004431 Walker A/P-loop; other site 573061004432 ATP binding site [chemical binding]; other site 573061004433 Q-loop/lid; other site 573061004434 ABC transporter signature motif; other site 573061004435 Walker B; other site 573061004436 D-loop; other site 573061004437 H-loop/switch region; other site 573061004438 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 573061004439 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 573061004440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061004441 Zn2+ binding site [ion binding]; other site 573061004442 Mg2+ binding site [ion binding]; other site 573061004443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061004444 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061004445 DNA binding site [nucleotide binding] 573061004446 domain linker motif; other site 573061004447 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573061004448 dimerization interface [polypeptide binding]; other site 573061004449 ligand binding site [chemical binding]; other site 573061004450 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573061004451 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 573061004452 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 573061004453 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 573061004454 ACS interaction site; other site 573061004455 CODH interaction site; other site 573061004456 cubane metal cluster (B-cluster) [ion binding]; other site 573061004457 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 573061004458 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573061004459 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573061004460 substrate binding site [chemical binding]; other site 573061004461 dimer interface [polypeptide binding]; other site 573061004462 ATP binding site [chemical binding]; other site 573061004463 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 573061004464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061004465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061004466 active site 573061004467 phosphorylation site [posttranslational modification] 573061004468 intermolecular recognition site; other site 573061004469 dimerization interface [polypeptide binding]; other site 573061004470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061004471 DNA binding site [nucleotide binding] 573061004472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061004473 dimer interface [polypeptide binding]; other site 573061004474 phosphorylation site [posttranslational modification] 573061004475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061004476 ATP binding site [chemical binding]; other site 573061004477 Mg2+ binding site [ion binding]; other site 573061004478 G-X-G motif; other site 573061004479 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061004480 Phosphotransferase enzyme family; Region: APH; pfam01636 573061004481 active site 573061004482 substrate binding site [chemical binding]; other site 573061004483 ATP binding site [chemical binding]; other site 573061004484 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573061004485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061004486 metal-binding site [ion binding] 573061004487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573061004488 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061004489 metal-binding site [ion binding] 573061004490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061004492 motif II; other site 573061004493 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 573061004494 dimerization interface [polypeptide binding]; other site 573061004495 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061004496 metal-binding site [ion binding] 573061004497 Uncharacterized conserved protein [Function unknown]; Region: COG2836 573061004498 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 573061004499 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 573061004500 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 573061004501 active site 573061004502 C-terminal domain interface [polypeptide binding]; other site 573061004503 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 573061004504 active site 573061004505 N-terminal domain interface [polypeptide binding]; other site 573061004506 Stage II sporulation protein; Region: SpoIID; pfam08486 573061004507 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 573061004508 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 573061004509 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061004510 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061004511 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573061004512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573061004513 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573061004514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061004515 dimer interface [polypeptide binding]; other site 573061004516 conserved gate region; other site 573061004517 putative PBP binding loops; other site 573061004518 ABC-ATPase subunit interface; other site 573061004519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061004520 Walker A/P-loop; other site 573061004521 ATP binding site [chemical binding]; other site 573061004522 ABC transporter; Region: ABC_tran; pfam00005 573061004523 Q-loop/lid; other site 573061004524 ABC transporter signature motif; other site 573061004525 Walker B; other site 573061004526 D-loop; other site 573061004527 H-loop/switch region; other site 573061004528 MarR family; Region: MarR_2; cl17246 573061004529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573061004530 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 573061004531 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 573061004532 NAD binding site [chemical binding]; other site 573061004533 dimer interface [polypeptide binding]; other site 573061004534 substrate binding site [chemical binding]; other site 573061004535 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061004536 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 573061004537 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573061004538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061004539 active site 573061004540 gamma-glutamyl kinase; Provisional; Region: PRK05429 573061004541 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573061004542 nucleotide binding site [chemical binding]; other site 573061004543 homotetrameric interface [polypeptide binding]; other site 573061004544 putative phosphate binding site [ion binding]; other site 573061004545 putative allosteric binding site; other site 573061004546 PUA domain; Region: PUA; pfam01472 573061004547 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573061004548 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573061004549 putative catalytic cysteine [active] 573061004550 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573061004551 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573061004552 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573061004553 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573061004554 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573061004555 RNA binding site [nucleotide binding]; other site 573061004556 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573061004557 RNA binding site [nucleotide binding]; other site 573061004558 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 573061004559 RNA binding site [nucleotide binding]; other site 573061004560 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573061004561 Predicted membrane protein [Function unknown]; Region: COG2246 573061004562 GtrA-like protein; Region: GtrA; pfam04138 573061004563 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573061004564 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573061004565 Ligand binding site; other site 573061004566 Putative Catalytic site; other site 573061004567 DXD motif; other site 573061004568 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 573061004569 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 573061004570 active site 573061004571 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004572 active site 573061004573 catalytic triad [active] 573061004574 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004575 active site 573061004576 catalytic triad [active] 573061004577 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004578 active site 573061004579 catalytic triad [active] 573061004580 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004581 active site 573061004582 catalytic triad [active] 573061004583 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004584 active site 573061004585 catalytic triad [active] 573061004586 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004587 active site 573061004588 catalytic triad [active] 573061004589 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061004590 active site 573061004591 catalytic triad [active] 573061004592 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573061004593 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573061004594 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573061004595 protein binding site [polypeptide binding]; other site 573061004596 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 573061004597 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573061004598 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573061004599 dihydroorotase; Validated; Region: pyrC; PRK09357 573061004600 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573061004601 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 573061004602 active site 573061004603 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573061004604 active site 573061004605 dimer interface [polypeptide binding]; other site 573061004606 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 573061004607 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 573061004608 FAD binding pocket [chemical binding]; other site 573061004609 FAD binding motif [chemical binding]; other site 573061004610 phosphate binding motif [ion binding]; other site 573061004611 beta-alpha-beta structure motif; other site 573061004612 NAD binding pocket [chemical binding]; other site 573061004613 Iron coordination center [ion binding]; other site 573061004614 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 573061004615 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 573061004616 heterodimer interface [polypeptide binding]; other site 573061004617 active site 573061004618 FMN binding site [chemical binding]; other site 573061004619 homodimer interface [polypeptide binding]; other site 573061004620 substrate binding site [chemical binding]; other site 573061004621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061004622 active site 573061004623 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061004624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061004625 Coenzyme A binding pocket [chemical binding]; other site 573061004626 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 573061004627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061004628 ATP binding site [chemical binding]; other site 573061004629 putative Mg++ binding site [ion binding]; other site 573061004630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061004631 nucleotide binding region [chemical binding]; other site 573061004632 ATP-binding site [chemical binding]; other site 573061004633 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 573061004634 HRDC domain; Region: HRDC; pfam00570 573061004635 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573061004636 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 573061004637 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573061004638 catalytic site [active] 573061004639 subunit interface [polypeptide binding]; other site 573061004640 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573061004641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573061004642 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573061004643 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573061004644 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573061004645 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061004646 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 573061004647 substrate binding site [chemical binding]; other site 573061004648 trigger factor; Provisional; Region: tig; PRK01490 573061004649 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573061004650 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573061004651 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 573061004652 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573061004653 oligomer interface [polypeptide binding]; other site 573061004654 active site residues [active] 573061004655 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573061004656 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573061004657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061004658 Walker A motif; other site 573061004659 ATP binding site [chemical binding]; other site 573061004660 Walker B motif; other site 573061004661 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573061004662 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 573061004663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061004664 Walker A motif; other site 573061004665 ATP binding site [chemical binding]; other site 573061004666 Walker B motif; other site 573061004667 arginine finger; other site 573061004668 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573061004669 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573061004670 Found in ATP-dependent protease La (LON); Region: LON; smart00464 573061004671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061004672 Walker A motif; other site 573061004673 ATP binding site [chemical binding]; other site 573061004674 Walker B motif; other site 573061004675 arginine finger; other site 573061004676 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573061004677 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 573061004678 G1 box; other site 573061004679 GTP/Mg2+ binding site [chemical binding]; other site 573061004680 Switch I region; other site 573061004681 G2 box; other site 573061004682 G3 box; other site 573061004683 Switch II region; other site 573061004684 G4 box; other site 573061004685 G5 box; other site 573061004686 Family description; Region: VCBS; pfam13517 573061004687 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573061004688 metal binding site 2 [ion binding]; metal-binding site 573061004689 putative DNA binding helix; other site 573061004690 metal binding site 1 [ion binding]; metal-binding site 573061004691 dimer interface [polypeptide binding]; other site 573061004692 structural Zn2+ binding site [ion binding]; other site 573061004693 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 573061004694 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 573061004695 putative active site [active] 573061004696 PhoH-like protein; Region: PhoH; pfam02562 573061004697 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 573061004698 Peptidase family M50; Region: Peptidase_M50; pfam02163 573061004699 active site 573061004700 putative substrate binding region [chemical binding]; other site 573061004701 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061004702 putative active site [active] 573061004703 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061004704 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061004705 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 573061004706 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 573061004707 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 573061004708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061004709 NAD(P) binding site [chemical binding]; other site 573061004710 active site 573061004711 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061004712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061004713 substrate binding pocket [chemical binding]; other site 573061004714 membrane-bound complex binding site; other site 573061004715 hinge residues; other site 573061004716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061004717 dimer interface [polypeptide binding]; other site 573061004718 conserved gate region; other site 573061004719 putative PBP binding loops; other site 573061004720 ABC-ATPase subunit interface; other site 573061004721 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573061004722 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573061004723 Walker A/P-loop; other site 573061004724 ATP binding site [chemical binding]; other site 573061004725 Q-loop/lid; other site 573061004726 ABC transporter signature motif; other site 573061004727 Walker B; other site 573061004728 D-loop; other site 573061004729 H-loop/switch region; other site 573061004730 Domain of unknown function (DUF378); Region: DUF378; pfam04070 573061004731 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 573061004732 AsnC family; Region: AsnC_trans_reg; pfam01037 573061004733 asparagine synthetase A; Reviewed; Region: PRK06462 573061004734 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573061004735 motif 1; other site 573061004736 dimer interface [polypeptide binding]; other site 573061004737 active site 573061004738 motif 2; other site 573061004739 motif 3; other site 573061004740 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 573061004741 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 573061004742 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 573061004743 active site 573061004744 dimer interface [polypeptide binding]; other site 573061004745 effector binding site; other site 573061004746 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573061004747 TSCPD domain; Region: TSCPD; pfam12637 573061004748 Protein of unknown function (DUF327); Region: DUF327; pfam03885 573061004749 NAD synthetase; Reviewed; Region: nadE; PRK02628 573061004750 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573061004751 multimer interface [polypeptide binding]; other site 573061004752 active site 573061004753 catalytic triad [active] 573061004754 protein interface 1 [polypeptide binding]; other site 573061004755 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573061004756 homodimer interface [polypeptide binding]; other site 573061004757 NAD binding pocket [chemical binding]; other site 573061004758 ATP binding pocket [chemical binding]; other site 573061004759 Mg binding site [ion binding]; other site 573061004760 active-site loop [active] 573061004761 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 573061004762 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573061004763 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573061004764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061004765 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573061004766 6-phosphofructokinase; Provisional; Region: PRK14072 573061004767 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 573061004768 active site 573061004769 ADP/pyrophosphate binding site [chemical binding]; other site 573061004770 dimerization interface [polypeptide binding]; other site 573061004771 allosteric effector site; other site 573061004772 fructose-1,6-bisphosphate binding site; other site 573061004773 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 573061004774 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 573061004775 active site 573061004776 Zn binding site [ion binding]; other site 573061004777 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 573061004778 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573061004779 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573061004780 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061004781 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061004782 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 573061004783 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 573061004784 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 573061004785 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573061004786 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573061004787 dimerization interface [polypeptide binding]; other site 573061004788 ATP binding site [chemical binding]; other site 573061004789 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573061004790 dimerization interface [polypeptide binding]; other site 573061004791 ATP binding site [chemical binding]; other site 573061004792 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 573061004793 putative active site [active] 573061004794 catalytic triad [active] 573061004795 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 573061004796 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 573061004797 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 573061004798 ATP binding site [chemical binding]; other site 573061004799 active site 573061004800 substrate binding site [chemical binding]; other site 573061004801 amidophosphoribosyltransferase; Provisional; Region: PRK05793 573061004802 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573061004803 active site 573061004804 tetramer interface [polypeptide binding]; other site 573061004805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061004806 active site 573061004807 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573061004808 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573061004809 dimerization interface [polypeptide binding]; other site 573061004810 putative ATP binding site [chemical binding]; other site 573061004811 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 573061004812 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573061004813 active site 573061004814 substrate binding site [chemical binding]; other site 573061004815 cosubstrate binding site; other site 573061004816 catalytic site [active] 573061004817 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 573061004818 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573061004819 purine monophosphate binding site [chemical binding]; other site 573061004820 dimer interface [polypeptide binding]; other site 573061004821 putative catalytic residues [active] 573061004822 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573061004823 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573061004824 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573061004825 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573061004826 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573061004827 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573061004828 homotrimer interaction site [polypeptide binding]; other site 573061004829 putative active site [active] 573061004830 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 573061004831 active site 573061004832 multimer interface [polypeptide binding]; other site 573061004833 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 573061004834 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 573061004835 active site 573061004836 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 573061004837 Pectate lyase; Region: Pec_lyase_C; cl01593 573061004838 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004839 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061004840 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061004841 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004842 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061004843 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573061004844 Part of AAA domain; Region: AAA_19; pfam13245 573061004845 Family description; Region: UvrD_C_2; pfam13538 573061004846 cell division protein FtsA; Region: ftsA; TIGR01174 573061004847 Cell division protein FtsA; Region: FtsA; smart00842 573061004848 Cell division protein FtsA; Region: FtsA; pfam14450 573061004849 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573061004850 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 573061004851 metal binding site [ion binding]; metal-binding site 573061004852 dimer interface [polypeptide binding]; other site 573061004853 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573061004854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061004855 RNA binding surface [nucleotide binding]; other site 573061004856 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573061004857 active site 573061004858 stage V sporulation protein B; Region: spore_V_B; TIGR02900 573061004859 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573061004860 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 573061004861 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573061004862 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573061004863 active site 573061004864 DNA binding site [nucleotide binding] 573061004865 Int/Topo IB signature motif; other site 573061004866 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 573061004867 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573061004868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061004869 FeS/SAM binding site; other site 573061004870 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 573061004871 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 573061004872 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573061004873 homodimer interaction site [polypeptide binding]; other site 573061004874 cofactor binding site; other site 573061004875 TfoX C-terminal domain; Region: TfoX_C; pfam04994 573061004876 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 573061004877 RNase E inhibitor protein; Provisional; Region: PRK11191 573061004878 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 573061004879 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061004880 DNA binding residues [nucleotide binding] 573061004881 dimer interface [polypeptide binding]; other site 573061004882 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061004883 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061004884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061004885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061004886 Walker A/P-loop; other site 573061004887 ATP binding site [chemical binding]; other site 573061004888 Q-loop/lid; other site 573061004889 ABC transporter signature motif; other site 573061004890 Walker B; other site 573061004891 D-loop; other site 573061004892 H-loop/switch region; other site 573061004893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061004894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061004895 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061004896 Walker A/P-loop; other site 573061004897 ATP binding site [chemical binding]; other site 573061004898 Q-loop/lid; other site 573061004899 ABC transporter signature motif; other site 573061004900 Walker B; other site 573061004901 D-loop; other site 573061004902 H-loop/switch region; other site 573061004903 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 573061004904 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 573061004905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061004906 FeS/SAM binding site; other site 573061004907 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 573061004908 V-type ATP synthase subunit I; Validated; Region: PRK05771 573061004909 V-type ATP synthase subunit K; Validated; Region: PRK06558 573061004910 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 573061004911 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 573061004912 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 573061004913 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 573061004914 V-type ATP synthase subunit C; Provisional; Region: PRK01198 573061004915 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 573061004916 V-type ATP synthase subunit F; Provisional; Region: PRK01395 573061004917 V-type ATP synthase subunit A; Provisional; Region: PRK04192 573061004918 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573061004919 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 573061004920 Walker A motif/ATP binding site; other site 573061004921 Walker B motif; other site 573061004922 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573061004923 V-type ATP synthase subunit B; Provisional; Region: PRK04196 573061004924 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573061004925 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 573061004926 Walker A motif homologous position; other site 573061004927 Walker B motif; other site 573061004928 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573061004929 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 573061004930 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 573061004931 Part of AAA domain; Region: AAA_19; pfam13245 573061004932 Family description; Region: UvrD_C_2; pfam13538 573061004933 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573061004934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061004935 Flavodoxin; Region: Flavodoxin_1; pfam00258 573061004936 Uncharacterized conserved protein [Function unknown]; Region: COG2454 573061004937 Arginase family; Region: Arginase; cd09989 573061004938 active site 573061004939 Mn binding site [ion binding]; other site 573061004940 oligomer interface [polypeptide binding]; other site 573061004941 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 573061004942 HPr kinase/phosphorylase; Provisional; Region: PRK05428 573061004943 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 573061004944 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 573061004945 Hpr binding site; other site 573061004946 active site 573061004947 homohexamer subunit interaction site [polypeptide binding]; other site 573061004948 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 573061004949 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 573061004950 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 573061004951 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 573061004952 oligomer interface [polypeptide binding]; other site 573061004953 metal binding site [ion binding]; metal-binding site 573061004954 metal binding site [ion binding]; metal-binding site 573061004955 putative Cl binding site [ion binding]; other site 573061004956 aspartate ring; other site 573061004957 basic sphincter; other site 573061004958 hydrophobic gate; other site 573061004959 periplasmic entrance; other site 573061004960 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 573061004961 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 573061004962 oligomer interface [polypeptide binding]; other site 573061004963 putative active site [active] 573061004964 metal binding site [ion binding]; metal-binding site 573061004965 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573061004966 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573061004967 active site 573061004968 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573061004969 active site 573061004970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061004971 Zn2+ binding site [ion binding]; other site 573061004972 Mg2+ binding site [ion binding]; other site 573061004973 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 573061004974 dihydropteroate synthase; Region: DHPS; TIGR01496 573061004975 substrate binding pocket [chemical binding]; other site 573061004976 dimer interface [polypeptide binding]; other site 573061004977 inhibitor binding site; inhibition site 573061004978 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 573061004979 homooctamer interface [polypeptide binding]; other site 573061004980 active site 573061004981 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 573061004982 catalytic center binding site [active] 573061004983 ATP binding site [chemical binding]; other site 573061004984 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573061004985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573061004986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061004987 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061004988 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 573061004989 NodB motif; other site 573061004990 active site 573061004991 catalytic site [active] 573061004992 Zn binding site [ion binding]; other site 573061004993 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 573061004994 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573061004995 dimer interface [polypeptide binding]; other site 573061004996 PYR/PP interface [polypeptide binding]; other site 573061004997 TPP binding site [chemical binding]; other site 573061004998 substrate binding site [chemical binding]; other site 573061004999 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573061005000 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573061005001 Domain of unknown function; Region: EKR; smart00890 573061005002 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061005003 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 573061005004 TPP-binding site [chemical binding]; other site 573061005005 dimer interface [polypeptide binding]; other site 573061005006 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573061005007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061005008 motif II; other site 573061005009 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573061005010 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 573061005011 substrate-cofactor binding pocket; other site 573061005012 homodimer interface [polypeptide binding]; other site 573061005013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061005014 catalytic residue [active] 573061005015 Uncharacterized conserved protein [Function unknown]; Region: COG1315 573061005016 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573061005017 CheD chemotactic sensory transduction; Region: CheD; cl00810 573061005018 CheB methylesterase; Region: CheB_methylest; pfam01339 573061005019 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573061005020 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573061005021 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573061005022 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573061005023 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573061005024 putative binding surface; other site 573061005025 active site 573061005026 P2 response regulator binding domain; Region: P2; pfam07194 573061005027 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573061005028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061005029 ATP binding site [chemical binding]; other site 573061005030 Mg2+ binding site [ion binding]; other site 573061005031 G-X-G motif; other site 573061005032 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573061005033 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 573061005034 CheC-like family; Region: CheC; pfam04509 573061005035 Chemotaxis phosphatase CheX; Region: CheX; cl15816 573061005036 CheC-like family; Region: CheC; pfam04509 573061005037 Response regulator receiver domain; Region: Response_reg; pfam00072 573061005038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061005039 active site 573061005040 phosphorylation site [posttranslational modification] 573061005041 intermolecular recognition site; other site 573061005042 dimerization interface [polypeptide binding]; other site 573061005043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573061005044 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 573061005045 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573061005046 flagellar motor switch protein; Validated; Region: PRK08119 573061005047 CheC-like family; Region: CheC; pfam04509 573061005048 CheC-like family; Region: CheC; pfam04509 573061005049 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 573061005050 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 573061005051 FlgN protein; Region: FlgN; pfam05130 573061005052 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 573061005053 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573061005054 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573061005055 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 573061005056 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061005057 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061005058 flagellar assembly protein FliW; Provisional; Region: PRK13285 573061005059 Global regulator protein family; Region: CsrA; pfam02599 573061005060 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 573061005061 flagellar capping protein; Validated; Region: fliD; PRK07737 573061005062 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 573061005063 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 573061005064 flagellin; Provisional; Region: PRK12804 573061005065 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061005066 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061005067 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 573061005068 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 573061005069 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573061005070 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573061005071 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 573061005072 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 573061005073 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 573061005074 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573061005075 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 573061005076 FliG C-terminal domain; Region: FliG_C; pfam01706 573061005077 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 573061005078 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 573061005079 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573061005080 Walker A motif/ATP binding site; other site 573061005081 Walker B motif; other site 573061005082 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 573061005083 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 573061005084 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 573061005085 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573061005086 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 573061005087 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 573061005088 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573061005089 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573061005090 Flagellar protein (FlbD); Region: FlbD; pfam06289 573061005091 flagellar motor protein MotP; Reviewed; Region: PRK06926 573061005092 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573061005093 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573061005094 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573061005095 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573061005096 ligand binding site [chemical binding]; other site 573061005097 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 573061005098 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 573061005099 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573061005100 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 573061005101 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 573061005102 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 573061005103 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573061005104 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 573061005105 FHIPEP family; Region: FHIPEP; pfam00771 573061005106 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 573061005107 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 573061005108 GTP/Mg2+ binding site [chemical binding]; other site 573061005109 G4 box; other site 573061005110 G5 box; other site 573061005111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061005112 G1 box; other site 573061005113 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573061005114 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573061005115 P-loop; other site 573061005116 PilZ domain; Region: PilZ; pfam07238 573061005117 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 573061005118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061005119 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573061005120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061005121 DNA binding residues [nucleotide binding] 573061005122 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573061005123 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 573061005124 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573061005125 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573061005126 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 573061005127 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573061005128 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573061005129 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 573061005130 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573061005131 DRTGG domain; Region: DRTGG; pfam07085 573061005132 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573061005133 DHH family; Region: DHH; pfam01368 573061005134 DHHA2 domain; Region: DHHA2; pfam02833 573061005135 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061005136 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 573061005137 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061005138 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573061005139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061005140 motif II; other site 573061005141 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573061005142 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 573061005143 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573061005144 intersubunit interface [polypeptide binding]; other site 573061005145 active site 573061005146 catalytic residue [active] 573061005147 AAA domain; Region: AAA_32; pfam13654 573061005148 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573061005149 GTP-binding protein YchF; Reviewed; Region: PRK09601 573061005150 YchF GTPase; Region: YchF; cd01900 573061005151 G1 box; other site 573061005152 GTP/Mg2+ binding site [chemical binding]; other site 573061005153 Switch I region; other site 573061005154 G2 box; other site 573061005155 Switch II region; other site 573061005156 G3 box; other site 573061005157 G4 box; other site 573061005158 G5 box; other site 573061005159 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573061005160 MraW methylase family; Region: Methyltransf_5; pfam01795 573061005161 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 573061005162 Septum formation initiator; Region: DivIC; cl17659 573061005163 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 573061005164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061005165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573061005166 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 573061005167 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 573061005168 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573061005169 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573061005170 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061005171 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061005172 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573061005173 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573061005174 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061005175 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061005176 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573061005177 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573061005178 Mg++ binding site [ion binding]; other site 573061005179 putative catalytic motif [active] 573061005180 putative substrate binding site [chemical binding]; other site 573061005181 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 573061005182 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 573061005183 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573061005184 active site 573061005185 substrate binding site [chemical binding]; other site 573061005186 cosubstrate binding site; other site 573061005187 catalytic site [active] 573061005188 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 573061005189 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573061005190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 573061005191 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 573061005192 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 573061005193 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 573061005194 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573061005195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573061005196 catalytic residue [active] 573061005197 Protein of unknown function (DUF552); Region: DUF552; cl00775 573061005198 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 573061005199 DivIVA protein; Region: DivIVA; pfam05103 573061005200 DivIVA domain; Region: DivI1A_domain; TIGR03544 573061005201 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 573061005202 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 573061005203 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 573061005204 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573061005205 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061005206 RNA binding surface [nucleotide binding]; other site 573061005207 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573061005208 active site 573061005209 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 573061005210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061005211 active site 573061005212 uracil transporter; Provisional; Region: PRK10720 573061005213 hypothetical protein; Reviewed; Region: PRK12497 573061005214 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 573061005215 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573061005216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061005217 Walker A motif; other site 573061005218 ATP binding site [chemical binding]; other site 573061005219 Walker B motif; other site 573061005220 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573061005221 DNA protecting protein DprA; Region: dprA; TIGR00732 573061005222 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 573061005223 DNA topoisomerase I; Validated; Region: PRK05582 573061005224 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573061005225 active site 573061005226 interdomain interaction site; other site 573061005227 putative metal-binding site [ion binding]; other site 573061005228 nucleotide binding site [chemical binding]; other site 573061005229 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573061005230 domain I; other site 573061005231 DNA binding groove [nucleotide binding] 573061005232 phosphate binding site [ion binding]; other site 573061005233 domain II; other site 573061005234 domain III; other site 573061005235 nucleotide binding site [chemical binding]; other site 573061005236 catalytic site [active] 573061005237 domain IV; other site 573061005238 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573061005239 transcriptional repressor CodY; Validated; Region: PRK04158 573061005240 CodY GAF-like domain; Region: CodY; pfam06018 573061005241 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 573061005242 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573061005243 rRNA interaction site [nucleotide binding]; other site 573061005244 S8 interaction site; other site 573061005245 putative laminin-1 binding site; other site 573061005246 elongation factor Ts; Provisional; Region: tsf; PRK09377 573061005247 UBA/TS-N domain; Region: UBA; pfam00627 573061005248 Elongation factor TS; Region: EF_TS; pfam00889 573061005249 Elongation factor TS; Region: EF_TS; pfam00889 573061005250 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573061005251 putative nucleotide binding site [chemical binding]; other site 573061005252 uridine monophosphate binding site [chemical binding]; other site 573061005253 homohexameric interface [polypeptide binding]; other site 573061005254 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573061005255 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573061005256 hinge region; other site 573061005257 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 573061005258 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 573061005259 catalytic residue [active] 573061005260 putative FPP diphosphate binding site; other site 573061005261 putative FPP binding hydrophobic cleft; other site 573061005262 dimer interface [polypeptide binding]; other site 573061005263 putative IPP diphosphate binding site; other site 573061005264 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573061005265 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 573061005266 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573061005267 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573061005268 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573061005269 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573061005270 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 573061005271 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573061005272 active site 573061005273 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573061005274 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573061005275 putative substrate binding region [chemical binding]; other site 573061005276 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573061005277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573061005278 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573061005279 DNA polymerase III PolC; Validated; Region: polC; PRK00448 573061005280 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 573061005281 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 573061005282 generic binding surface II; other site 573061005283 generic binding surface I; other site 573061005284 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573061005285 active site 573061005286 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573061005287 active site 573061005288 catalytic site [active] 573061005289 substrate binding site [chemical binding]; other site 573061005290 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 573061005291 ribosome maturation protein RimP; Reviewed; Region: PRK00092 573061005292 Sm and related proteins; Region: Sm_like; cl00259 573061005293 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 573061005294 putative oligomer interface [polypeptide binding]; other site 573061005295 putative RNA binding site [nucleotide binding]; other site 573061005296 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 573061005297 NusA N-terminal domain; Region: NusA_N; pfam08529 573061005298 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573061005299 RNA binding site [nucleotide binding]; other site 573061005300 homodimer interface [polypeptide binding]; other site 573061005301 NusA-like KH domain; Region: KH_5; pfam13184 573061005302 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573061005303 G-X-X-G motif; other site 573061005304 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 573061005305 putative RNA binding cleft [nucleotide binding]; other site 573061005306 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 573061005307 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573061005308 translation initiation factor IF-2; Region: IF-2; TIGR00487 573061005309 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573061005310 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573061005311 G1 box; other site 573061005312 putative GEF interaction site [polypeptide binding]; other site 573061005313 GTP/Mg2+ binding site [chemical binding]; other site 573061005314 Switch I region; other site 573061005315 G2 box; other site 573061005316 G3 box; other site 573061005317 Switch II region; other site 573061005318 G4 box; other site 573061005319 G5 box; other site 573061005320 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573061005321 Translation-initiation factor 2; Region: IF-2; pfam11987 573061005322 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573061005323 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 573061005324 DHH family; Region: DHH; pfam01368 573061005325 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 573061005326 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573061005327 RNA binding site [nucleotide binding]; other site 573061005328 active site 573061005329 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573061005330 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 573061005331 active site 573061005332 Riboflavin kinase; Region: Flavokinase; pfam01687 573061005333 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573061005334 16S/18S rRNA binding site [nucleotide binding]; other site 573061005335 S13e-L30e interaction site [polypeptide binding]; other site 573061005336 25S rRNA binding site [nucleotide binding]; other site 573061005337 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573061005338 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 573061005339 RNase E interface [polypeptide binding]; other site 573061005340 trimer interface [polypeptide binding]; other site 573061005341 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573061005342 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573061005343 RNase E interface [polypeptide binding]; other site 573061005344 trimer interface [polypeptide binding]; other site 573061005345 active site 573061005346 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573061005347 putative nucleic acid binding region [nucleotide binding]; other site 573061005348 G-X-X-G motif; other site 573061005349 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573061005350 RNA binding site [nucleotide binding]; other site 573061005351 domain interface; other site 573061005352 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573061005353 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573061005354 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573061005355 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 573061005356 aspartate kinase I; Reviewed; Region: PRK08210 573061005357 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573061005358 nucleotide binding site [chemical binding]; other site 573061005359 substrate binding site [chemical binding]; other site 573061005360 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 573061005361 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573061005362 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573061005363 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 573061005364 active site 573061005365 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 573061005366 Uncharacterized conserved protein [Function unknown]; Region: COG2966 573061005367 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 573061005368 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 573061005369 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 573061005370 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 573061005371 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573061005372 dimer interface [polypeptide binding]; other site 573061005373 active site 573061005374 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573061005375 folate binding site [chemical binding]; other site 573061005376 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061005377 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 573061005378 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573061005379 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 573061005380 Part of AAA domain; Region: AAA_19; pfam13245 573061005381 Family description; Region: UvrD_C_2; pfam13538 573061005382 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573061005383 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 573061005384 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 573061005385 generic binding surface II; other site 573061005386 generic binding surface I; other site 573061005387 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061005388 Zn2+ binding site [ion binding]; other site 573061005389 Mg2+ binding site [ion binding]; other site 573061005390 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061005391 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061005392 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 573061005393 Pyruvate formate lyase 1; Region: PFL1; cd01678 573061005394 coenzyme A binding site [chemical binding]; other site 573061005395 active site 573061005396 catalytic residues [active] 573061005397 glycine loop; other site 573061005398 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 573061005399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061005400 FeS/SAM binding site; other site 573061005401 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573061005402 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573061005403 recombination factor protein RarA; Reviewed; Region: PRK13342 573061005404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061005405 Walker A motif; other site 573061005406 ATP binding site [chemical binding]; other site 573061005407 Walker B motif; other site 573061005408 arginine finger; other site 573061005409 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573061005410 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 573061005411 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 573061005412 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573061005413 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573061005414 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573061005415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061005416 Response regulator receiver domain; Region: Response_reg; pfam00072 573061005417 active site 573061005418 phosphorylation site [posttranslational modification] 573061005419 intermolecular recognition site; other site 573061005420 dimerization interface [polypeptide binding]; other site 573061005421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061005422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061005423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061005424 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061005425 HAMP domain; Region: HAMP; pfam00672 573061005426 Histidine kinase; Region: His_kinase; pfam06580 573061005427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061005428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061005429 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573061005430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061005431 dimer interface [polypeptide binding]; other site 573061005432 conserved gate region; other site 573061005433 putative PBP binding loops; other site 573061005434 ABC-ATPase subunit interface; other site 573061005435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061005437 dimer interface [polypeptide binding]; other site 573061005438 conserved gate region; other site 573061005439 putative PBP binding loops; other site 573061005440 ABC-ATPase subunit interface; other site 573061005441 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 573061005442 active site 573061005443 Predicted transcriptional regulator [Transcription]; Region: COG1959 573061005444 Transcriptional regulator; Region: Rrf2; cl17282 573061005445 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573061005446 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573061005447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061005448 catalytic residue [active] 573061005449 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573061005450 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573061005451 trimerization site [polypeptide binding]; other site 573061005452 active site 573061005453 PRC-barrel domain; Region: PRC; pfam05239 573061005454 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573061005455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573061005456 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573061005457 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573061005458 motif 1; other site 573061005459 active site 573061005460 motif 2; other site 573061005461 motif 3; other site 573061005462 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573061005463 DHHA1 domain; Region: DHHA1; pfam02272 573061005464 hypothetical protein; Provisional; Region: PRK05473 573061005465 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 573061005466 ferric uptake regulator; Provisional; Region: fur; PRK09462 573061005467 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573061005468 metal binding site 2 [ion binding]; metal-binding site 573061005469 putative DNA binding helix; other site 573061005470 metal binding site 1 [ion binding]; metal-binding site 573061005471 dimer interface [polypeptide binding]; other site 573061005472 structural Zn2+ binding site [ion binding]; other site 573061005473 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 573061005474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061005475 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 573061005476 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573061005477 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573061005478 G1 box; other site 573061005479 putative GEF interaction site [polypeptide binding]; other site 573061005480 GTP/Mg2+ binding site [chemical binding]; other site 573061005481 Switch I region; other site 573061005482 G2 box; other site 573061005483 G3 box; other site 573061005484 Switch II region; other site 573061005485 G4 box; other site 573061005486 G5 box; other site 573061005487 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573061005488 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573061005489 YceG-like family; Region: YceG; pfam02618 573061005490 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 573061005491 dimerization interface [polypeptide binding]; other site 573061005492 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 573061005493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061005494 S-adenosylmethionine binding site [chemical binding]; other site 573061005495 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573061005496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573061005497 Peptidase family U32; Region: Peptidase_U32; pfam01136 573061005498 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 573061005499 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 573061005500 Sugar specificity; other site 573061005501 Pyrimidine base specificity; other site 573061005502 ATP-binding site [chemical binding]; other site 573061005503 sporulation sigma factor SigK; Reviewed; Region: PRK05803 573061005504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061005505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061005506 DNA binding residues [nucleotide binding] 573061005507 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 573061005508 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 573061005509 Walker A motif; other site 573061005510 ATP binding site [chemical binding]; other site 573061005511 Walker B motif; other site 573061005512 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 573061005513 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 573061005514 DXD motif; other site 573061005515 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 573061005516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573061005517 nucleotide binding site [chemical binding]; other site 573061005518 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 573061005519 Cell division protein FtsA; Region: FtsA; pfam14450 573061005520 cell division protein FtsZ; Validated; Region: PRK09330 573061005521 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573061005522 nucleotide binding site [chemical binding]; other site 573061005523 SulA interaction site; other site 573061005524 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 573061005525 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 573061005526 sporulation sigma factor SigE; Reviewed; Region: PRK08301 573061005527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061005528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061005529 DNA binding residues [nucleotide binding] 573061005530 sporulation sigma factor SigG; Reviewed; Region: PRK08215 573061005531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061005532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573061005533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061005534 DNA binding residues [nucleotide binding] 573061005535 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 573061005536 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 573061005537 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573061005538 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061005539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061005540 active site 573061005541 phosphorylation site [posttranslational modification] 573061005542 intermolecular recognition site; other site 573061005543 dimerization interface [polypeptide binding]; other site 573061005544 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061005545 DNA binding site [nucleotide binding] 573061005546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061005547 dimerization interface [polypeptide binding]; other site 573061005548 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573061005549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061005550 dimer interface [polypeptide binding]; other site 573061005551 phosphorylation site [posttranslational modification] 573061005552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061005553 ATP binding site [chemical binding]; other site 573061005554 Mg2+ binding site [ion binding]; other site 573061005555 G-X-G motif; other site 573061005556 PBP superfamily domain; Region: PBP_like_2; cl17296 573061005557 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573061005558 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 573061005559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061005560 dimer interface [polypeptide binding]; other site 573061005561 conserved gate region; other site 573061005562 putative PBP binding loops; other site 573061005563 ABC-ATPase subunit interface; other site 573061005564 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 573061005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061005566 dimer interface [polypeptide binding]; other site 573061005567 conserved gate region; other site 573061005568 putative PBP binding loops; other site 573061005569 ABC-ATPase subunit interface; other site 573061005570 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 573061005571 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573061005572 Walker A/P-loop; other site 573061005573 ATP binding site [chemical binding]; other site 573061005574 Q-loop/lid; other site 573061005575 ABC transporter signature motif; other site 573061005576 Walker B; other site 573061005577 D-loop; other site 573061005578 H-loop/switch region; other site 573061005579 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573061005580 PhoU domain; Region: PhoU; pfam01895 573061005581 PhoU domain; Region: PhoU; pfam01895 573061005582 Cache domain; Region: Cache_1; pfam02743 573061005583 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061005584 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061005585 dimer interface [polypeptide binding]; other site 573061005586 putative CheW interface [polypeptide binding]; other site 573061005587 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573061005588 PhoU domain; Region: PhoU; pfam01895 573061005589 PhoU domain; Region: PhoU; pfam01895 573061005590 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573061005591 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 573061005592 Protein of unknown function (DUF512); Region: DUF512; pfam04459 573061005593 GTP-binding protein Der; Reviewed; Region: PRK00093 573061005594 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573061005595 G1 box; other site 573061005596 GTP/Mg2+ binding site [chemical binding]; other site 573061005597 Switch I region; other site 573061005598 G2 box; other site 573061005599 Switch II region; other site 573061005600 G3 box; other site 573061005601 G4 box; other site 573061005602 G5 box; other site 573061005603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573061005604 G1 box; other site 573061005605 GTP/Mg2+ binding site [chemical binding]; other site 573061005606 Switch I region; other site 573061005607 G2 box; other site 573061005608 G3 box; other site 573061005609 Switch II region; other site 573061005610 G4 box; other site 573061005611 G5 box; other site 573061005612 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 573061005613 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 573061005614 G1 box; other site 573061005615 GTP/Mg2+ binding site [chemical binding]; other site 573061005616 G2 box; other site 573061005617 Switch I region; other site 573061005618 G3 box; other site 573061005619 Switch II region; other site 573061005620 G4 box; other site 573061005621 G5 box; other site 573061005622 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 573061005623 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 573061005624 active site 573061005625 dimer interface [polypeptide binding]; other site 573061005626 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 573061005627 active site 573061005628 homotetramer interface [polypeptide binding]; other site 573061005629 homodimer interface [polypeptide binding]; other site 573061005630 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573061005631 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573061005632 hypothetical protein; Provisional; Region: PRK11820 573061005633 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 573061005634 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 573061005635 hypothetical protein; Provisional; Region: PRK04323 573061005636 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 573061005637 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573061005638 catalytic site [active] 573061005639 G-X2-G-X-G-K; other site 573061005640 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573061005641 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573061005642 Flavoprotein; Region: Flavoprotein; pfam02441 573061005643 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 573061005644 primosome assembly protein PriA; Validated; Region: PRK05580 573061005645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061005646 ATP binding site [chemical binding]; other site 573061005647 putative Mg++ binding site [ion binding]; other site 573061005648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061005649 nucleotide binding region [chemical binding]; other site 573061005650 ATP-binding site [chemical binding]; other site 573061005651 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573061005652 active site 573061005653 catalytic residues [active] 573061005654 metal binding site [ion binding]; metal-binding site 573061005655 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573061005656 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573061005657 putative active site [active] 573061005658 substrate binding site [chemical binding]; other site 573061005659 putative cosubstrate binding site; other site 573061005660 catalytic site [active] 573061005661 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573061005662 substrate binding site [chemical binding]; other site 573061005663 16S rRNA methyltransferase B; Provisional; Region: PRK14902 573061005664 NusB family; Region: NusB; pfam01029 573061005665 putative RNA binding site [nucleotide binding]; other site 573061005666 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 573061005667 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 573061005668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061005669 FeS/SAM binding site; other site 573061005670 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 573061005671 Protein phosphatase 2C; Region: PP2C; pfam00481 573061005672 active site 573061005673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573061005674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573061005675 active site 573061005676 ATP binding site [chemical binding]; other site 573061005677 substrate binding site [chemical binding]; other site 573061005678 activation loop (A-loop); other site 573061005679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 573061005680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573061005681 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573061005682 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573061005683 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573061005684 GTPase RsgA; Reviewed; Region: PRK00098 573061005685 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 573061005686 RNA binding site [nucleotide binding]; other site 573061005687 homodimer interface [polypeptide binding]; other site 573061005688 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573061005689 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573061005690 GTP/Mg2+ binding site [chemical binding]; other site 573061005691 G4 box; other site 573061005692 G5 box; other site 573061005693 G1 box; other site 573061005694 Switch I region; other site 573061005695 G2 box; other site 573061005696 G3 box; other site 573061005697 Switch II region; other site 573061005698 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 573061005699 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573061005700 substrate binding site [chemical binding]; other site 573061005701 hexamer interface [polypeptide binding]; other site 573061005702 metal binding site [ion binding]; metal-binding site 573061005703 Thiamine pyrophosphokinase; Region: TPK; cd07995 573061005704 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 573061005705 active site 573061005706 dimerization interface [polypeptide binding]; other site 573061005707 thiamine binding site [chemical binding]; other site 573061005708 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573061005709 Asp23 family; Region: Asp23; pfam03780 573061005710 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 573061005711 DAK2 domain; Region: Dak2; pfam02734 573061005712 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573061005713 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573061005714 ssDNA binding site; other site 573061005715 generic binding surface II; other site 573061005716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061005717 ATP binding site [chemical binding]; other site 573061005718 putative Mg++ binding site [ion binding]; other site 573061005719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061005720 nucleotide binding region [chemical binding]; other site 573061005721 ATP-binding site [chemical binding]; other site 573061005722 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 573061005723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061005724 S-adenosylmethionine binding site [chemical binding]; other site 573061005725 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573061005726 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573061005727 active site 573061005728 (T/H)XGH motif; other site 573061005729 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 573061005730 Nucleoside recognition; Region: Gate; pfam07670 573061005731 hypothetical protein; Provisional; Region: PRK13670 573061005732 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 573061005733 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 573061005734 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 573061005735 propionate/acetate kinase; Provisional; Region: PRK12379 573061005736 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 573061005737 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 573061005738 putative phosphate acyltransferase; Provisional; Region: PRK05331 573061005739 acyl carrier protein; Provisional; Region: acpP; PRK00982 573061005740 ribonuclease III; Reviewed; Region: rnc; PRK00102 573061005741 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573061005742 dimerization interface [polypeptide binding]; other site 573061005743 active site 573061005744 metal binding site [ion binding]; metal-binding site 573061005745 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573061005746 dsRNA binding site [nucleotide binding]; other site 573061005747 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573061005748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061005749 FeS/SAM binding site; other site 573061005750 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573061005751 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573061005752 Walker A/P-loop; other site 573061005753 ATP binding site [chemical binding]; other site 573061005754 Q-loop/lid; other site 573061005755 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 573061005756 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573061005757 ABC transporter signature motif; other site 573061005758 Walker B; other site 573061005759 D-loop; other site 573061005760 H-loop/switch region; other site 573061005761 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573061005762 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573061005763 P loop; other site 573061005764 GTP binding site [chemical binding]; other site 573061005765 putative DNA-binding protein; Validated; Region: PRK00118 573061005766 signal recognition particle protein; Provisional; Region: PRK10867 573061005767 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573061005768 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573061005769 P loop; other site 573061005770 GTP binding site [chemical binding]; other site 573061005771 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573061005772 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 573061005773 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 573061005774 hypothetical protein; Provisional; Region: PRK00468 573061005775 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 573061005776 RimM N-terminal domain; Region: RimM; pfam01782 573061005777 PRC-barrel domain; Region: PRC; pfam05239 573061005778 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573061005779 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573061005780 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 573061005781 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 573061005782 GTP/Mg2+ binding site [chemical binding]; other site 573061005783 G4 box; other site 573061005784 G5 box; other site 573061005785 G1 box; other site 573061005786 Switch I region; other site 573061005787 G2 box; other site 573061005788 G3 box; other site 573061005789 Switch II region; other site 573061005790 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573061005791 RNA/DNA hybrid binding site [nucleotide binding]; other site 573061005792 active site 573061005793 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 573061005794 Domain of unknown function (DUF814); Region: DUF814; pfam05670 573061005795 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061005796 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061005797 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061005798 Type II/IV secretion system protein; Region: T2SE; pfam00437 573061005799 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573061005800 Walker A motif; other site 573061005801 ATP binding site [chemical binding]; other site 573061005802 Walker B motif; other site 573061005803 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573061005804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573061005805 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 573061005806 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573061005807 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573061005808 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 573061005809 active site 573061005810 elongation factor P; Validated; Region: PRK00529 573061005811 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573061005812 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573061005813 RNA binding site [nucleotide binding]; other site 573061005814 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573061005815 RNA binding site [nucleotide binding]; other site 573061005816 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 573061005817 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 573061005818 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573061005819 Walker A motif; other site 573061005820 ATP binding site [chemical binding]; other site 573061005821 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 573061005822 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 573061005823 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 573061005824 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 573061005825 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562 573061005826 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 573061005827 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 573061005828 Asp23 family; Region: Asp23; pfam03780 573061005829 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 573061005830 putative RNA binding site [nucleotide binding]; other site 573061005831 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 573061005832 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573061005833 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573061005834 homodimer interface [polypeptide binding]; other site 573061005835 NADP binding site [chemical binding]; other site 573061005836 substrate binding site [chemical binding]; other site 573061005837 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573061005838 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573061005839 generic binding surface II; other site 573061005840 generic binding surface I; other site 573061005841 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 573061005842 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573061005843 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573061005844 substrate binding pocket [chemical binding]; other site 573061005845 chain length determination region; other site 573061005846 substrate-Mg2+ binding site; other site 573061005847 catalytic residues [active] 573061005848 aspartate-rich region 1; other site 573061005849 active site lid residues [active] 573061005850 aspartate-rich region 2; other site 573061005851 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 573061005852 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573061005853 TPP-binding site; other site 573061005854 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573061005855 PYR/PP interface [polypeptide binding]; other site 573061005856 dimer interface [polypeptide binding]; other site 573061005857 TPP binding site [chemical binding]; other site 573061005858 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573061005859 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 573061005860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061005861 RNA binding surface [nucleotide binding]; other site 573061005862 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 573061005863 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 573061005864 ATP-NAD kinase; Region: NAD_kinase; pfam01513 573061005865 arginine repressor; Provisional; Region: argR; PRK00441 573061005866 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 573061005867 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 573061005868 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573061005869 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573061005870 Walker A/P-loop; other site 573061005871 ATP binding site [chemical binding]; other site 573061005872 Q-loop/lid; other site 573061005873 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573061005874 Q-loop/lid; other site 573061005875 ABC transporter signature motif; other site 573061005876 Walker B; other site 573061005877 D-loop; other site 573061005878 H-loop/switch region; other site 573061005879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573061005880 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 573061005881 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 573061005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061005883 active site 573061005884 phosphorylation site [posttranslational modification] 573061005885 intermolecular recognition site; other site 573061005886 dimerization interface [polypeptide binding]; other site 573061005887 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 573061005888 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 573061005889 pentamer interface [polypeptide binding]; other site 573061005890 dodecaamer interface [polypeptide binding]; other site 573061005891 Predicted methyltransferases [General function prediction only]; Region: COG1568 573061005892 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573061005893 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061005894 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 573061005895 aspartate aminotransferase; Provisional; Region: PRK06836 573061005896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061005897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061005898 homodimer interface [polypeptide binding]; other site 573061005899 catalytic residue [active] 573061005900 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 573061005901 dimer interface [polypeptide binding]; other site 573061005902 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 573061005903 active site 573061005904 metal binding site [ion binding]; metal-binding site 573061005905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 573061005906 Uncharacterized conserved protein [Function unknown]; Region: COG1543 573061005907 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 573061005908 active site 573061005909 substrate binding site [chemical binding]; other site 573061005910 catalytic site [active] 573061005911 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 573061005912 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573061005913 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573061005914 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573061005915 recombination regulator RecX; Provisional; Region: recX; PRK14134 573061005916 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573061005917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061005918 binding surface 573061005919 TPR repeat; Region: TPR_11; pfam13414 573061005920 TPR motif; other site 573061005921 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573061005922 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 573061005923 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573061005924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 573061005925 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 573061005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 573061005927 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573061005928 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061005929 active site 573061005930 HIGH motif; other site 573061005931 nucleotide binding site [chemical binding]; other site 573061005932 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573061005933 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573061005934 active site 573061005935 KMSKS motif; other site 573061005936 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573061005937 tRNA binding surface [nucleotide binding]; other site 573061005938 anticodon binding site; other site 573061005939 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573061005940 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 573061005941 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061005942 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061005943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573061005944 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573061005945 active site 573061005946 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573061005947 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573061005948 inhibitor-cofactor binding pocket; inhibition site 573061005949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061005950 catalytic residue [active] 573061005951 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 573061005952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061005953 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 573061005954 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061005955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061005956 active site 573061005957 metal binding site [ion binding]; metal-binding site 573061005958 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061005959 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573061005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061005961 NAD(P) binding site [chemical binding]; other site 573061005962 active site 573061005963 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 573061005964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061005965 NAD(P) binding site [chemical binding]; other site 573061005966 active site 573061005967 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573061005968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573061005969 active site 573061005970 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573061005971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573061005972 active site 573061005973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573061005974 active site 573061005975 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061005976 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573061005977 TSCPD domain; Region: TSCPD; cl14834 573061005978 Uncharacterized conserved protein [Function unknown]; Region: COG3391 573061005979 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 573061005980 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061005981 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573061005982 NodB motif; other site 573061005983 active site 573061005984 catalytic site [active] 573061005985 metal binding site [ion binding]; metal-binding site 573061005986 single-stranded DNA-binding protein; Provisional; Region: PRK05813 573061005987 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573061005988 dimer interface [polypeptide binding]; other site 573061005989 ssDNA binding site [nucleotide binding]; other site 573061005990 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061005991 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 573061005992 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 573061005993 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 573061005994 active site 573061005995 trimer interface [polypeptide binding]; other site 573061005996 substrate binding site [chemical binding]; other site 573061005997 CoA binding site [chemical binding]; other site 573061005998 aminotransferase A; Validated; Region: PRK07683 573061005999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061006000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006001 homodimer interface [polypeptide binding]; other site 573061006002 catalytic residue [active] 573061006003 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573061006004 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573061006005 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573061006006 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573061006007 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573061006008 dimer interface [polypeptide binding]; other site 573061006009 active site 573061006010 catalytic residue [active] 573061006011 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573061006012 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573061006013 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 573061006014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061006015 S-adenosylmethionine binding site [chemical binding]; other site 573061006016 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 573061006017 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 573061006018 dimerization interface [polypeptide binding]; other site 573061006019 domain crossover interface; other site 573061006020 redox-dependent activation switch; other site 573061006021 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061006022 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 573061006023 Protein of unknown function DUF89; Region: DUF89; cl15397 573061006024 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 573061006025 Sensory domain found in PocR; Region: PocR; pfam10114 573061006026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061006027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061006028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061006029 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 573061006030 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 573061006031 dimer interface [polypeptide binding]; other site 573061006032 active site 573061006033 metal binding site [ion binding]; metal-binding site 573061006034 dihydroxyacetone kinase; Provisional; Region: PRK14479 573061006035 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 573061006036 DAK2 domain; Region: Dak2; pfam02734 573061006037 Flavin Reductases; Region: FlaRed; cl00801 573061006038 putative transposase OrfB; Reviewed; Region: PHA02517 573061006039 HTH-like domain; Region: HTH_21; pfam13276 573061006040 Integrase core domain; Region: rve; pfam00665 573061006041 Integrase core domain; Region: rve_3; pfam13683 573061006042 Homeodomain-like domain; Region: HTH_23; cl17451 573061006043 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 573061006044 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 573061006045 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 573061006046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 573061006047 heme pocket [chemical binding]; other site 573061006048 PAS fold; Region: PAS_4; pfam08448 573061006049 PAS domain S-box; Region: sensory_box; TIGR00229 573061006050 PAS domain; Region: PAS_9; pfam13426 573061006051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061006052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061006053 dimer interface [polypeptide binding]; other site 573061006054 phosphorylation site [posttranslational modification] 573061006055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061006056 ATP binding site [chemical binding]; other site 573061006057 Mg2+ binding site [ion binding]; other site 573061006058 G-X-G motif; other site 573061006059 YtxC-like family; Region: YtxC; pfam08812 573061006060 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 573061006061 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 573061006062 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573061006063 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573061006064 active site 573061006065 dimer interface [polypeptide binding]; other site 573061006066 motif 1; other site 573061006067 motif 2; other site 573061006068 motif 3; other site 573061006069 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573061006070 anticodon binding site; other site 573061006071 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573061006072 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573061006073 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573061006074 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573061006075 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573061006076 23S rRNA binding site [nucleotide binding]; other site 573061006077 L21 binding site [polypeptide binding]; other site 573061006078 L13 binding site [polypeptide binding]; other site 573061006079 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573061006080 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 573061006081 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573061006082 TrkA-N domain; Region: TrkA_N; pfam02254 573061006083 TrkA-C domain; Region: TrkA_C; pfam02080 573061006084 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573061006085 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 573061006086 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573061006087 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573061006088 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573061006089 GatB domain; Region: GatB_Yqey; smart00845 573061006090 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 573061006091 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573061006092 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 573061006093 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 573061006094 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 573061006095 Dimer interface [polypeptide binding]; other site 573061006096 anticodon binding site; other site 573061006097 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 573061006098 homodimer interface [polypeptide binding]; other site 573061006099 motif 1; other site 573061006100 motif 2; other site 573061006101 active site 573061006102 motif 3; other site 573061006103 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 573061006104 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 573061006105 catalytic residue [active] 573061006106 putative FPP diphosphate binding site; other site 573061006107 putative FPP binding hydrophobic cleft; other site 573061006108 dimer interface [polypeptide binding]; other site 573061006109 putative IPP diphosphate binding site; other site 573061006110 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 573061006111 Uncharacterized conserved protein [Function unknown]; Region: COG4198 573061006112 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 573061006113 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573061006114 putative ligand binding site [chemical binding]; other site 573061006115 putative NAD binding site [chemical binding]; other site 573061006116 putative catalytic site [active] 573061006117 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 573061006118 L-serine binding site [chemical binding]; other site 573061006119 ACT domain interface; other site 573061006120 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 573061006121 dinuclear metal binding motif [ion binding]; other site 573061006122 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573061006123 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573061006124 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573061006125 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573061006126 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573061006127 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 573061006128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061006129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061006130 Cell division protein ZapA; Region: ZapA; pfam05164 573061006131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061006132 acyl-CoA synthetase; Validated; Region: PRK09192 573061006133 acyl-activating enzyme (AAE) consensus motif; other site 573061006134 AMP binding site [chemical binding]; other site 573061006135 active site 573061006136 CoA binding site [chemical binding]; other site 573061006137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061006138 Condensation domain; Region: Condensation; pfam00668 573061006139 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061006140 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061006141 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061006142 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061006143 acyl-activating enzyme (AAE) consensus motif; other site 573061006144 AMP binding site [chemical binding]; other site 573061006145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061006146 Condensation domain; Region: Condensation; pfam00668 573061006147 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 573061006148 Condensation domain; Region: Condensation; pfam00668 573061006149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061006150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061006151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061006152 putative substrate translocation pore; other site 573061006153 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 573061006154 homodimer interface [polypeptide binding]; other site 573061006155 substrate-cofactor binding pocket; other site 573061006156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006157 catalytic residue [active] 573061006158 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 573061006159 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 573061006160 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573061006161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006162 FeS/SAM binding site; other site 573061006163 TRAM domain; Region: TRAM; pfam01938 573061006164 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573061006165 MutS domain I; Region: MutS_I; pfam01624 573061006166 MutS domain II; Region: MutS_II; pfam05188 573061006167 MutS domain III; Region: MutS_III; pfam05192 573061006168 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 573061006169 Walker A/P-loop; other site 573061006170 ATP binding site [chemical binding]; other site 573061006171 Q-loop/lid; other site 573061006172 ABC transporter signature motif; other site 573061006173 Walker B; other site 573061006174 D-loop; other site 573061006175 H-loop/switch region; other site 573061006176 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 573061006177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061006178 ATP binding site [chemical binding]; other site 573061006179 Mg2+ binding site [ion binding]; other site 573061006180 G-X-G motif; other site 573061006181 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 573061006182 ATP binding site [chemical binding]; other site 573061006183 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 573061006184 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573061006185 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573061006186 bacterial Hfq-like; Region: Hfq; cd01716 573061006187 hexamer interface [polypeptide binding]; other site 573061006188 Sm1 motif; other site 573061006189 RNA binding site [nucleotide binding]; other site 573061006190 Sm2 motif; other site 573061006191 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 573061006192 Aluminium resistance protein; Region: Alum_res; pfam06838 573061006193 LexA repressor; Validated; Region: PRK00215 573061006194 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573061006195 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573061006196 Catalytic site [active] 573061006197 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 573061006198 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573061006199 dimer interface [polypeptide binding]; other site 573061006200 ADP-ribose binding site [chemical binding]; other site 573061006201 active site 573061006202 nudix motif; other site 573061006203 metal binding site [ion binding]; metal-binding site 573061006204 Integral membrane protein DUF95; Region: DUF95; cl00572 573061006205 purine nucleoside phosphorylase; Provisional; Region: PRK08202 573061006206 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 573061006207 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573061006208 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573061006209 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 573061006210 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 573061006211 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573061006212 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 573061006213 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 573061006214 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 573061006215 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 573061006216 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 573061006217 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573061006218 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573061006219 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 573061006220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061006221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061006222 DNA binding residues [nucleotide binding] 573061006223 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573061006224 MULE transposase domain; Region: MULE; pfam10551 573061006225 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 573061006226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573061006227 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573061006228 active site 573061006229 DNA binding site [nucleotide binding] 573061006230 Int/Topo IB signature motif; other site 573061006231 TPR repeat; Region: TPR_11; pfam13414 573061006232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006233 binding surface 573061006234 TPR motif; other site 573061006235 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 573061006236 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 573061006237 tetramer interface [polypeptide binding]; other site 573061006238 active site 573061006239 Domain of unknown function (DUF378); Region: DUF378; cl00943 573061006240 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573061006241 dimerization domain swap beta strand [polypeptide binding]; other site 573061006242 regulatory protein interface [polypeptide binding]; other site 573061006243 active site 573061006244 regulatory phosphorylation site [posttranslational modification]; other site 573061006245 aspartate aminotransferase; Provisional; Region: PRK05764 573061006246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061006247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006248 homodimer interface [polypeptide binding]; other site 573061006249 catalytic residue [active] 573061006250 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 573061006251 phosphodiesterase; Provisional; Region: PRK12704 573061006252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061006253 Zn2+ binding site [ion binding]; other site 573061006254 Mg2+ binding site [ion binding]; other site 573061006255 recombinase A; Provisional; Region: recA; PRK09354 573061006256 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573061006257 hexamer interface [polypeptide binding]; other site 573061006258 Walker A motif; other site 573061006259 ATP binding site [chemical binding]; other site 573061006260 Walker B motif; other site 573061006261 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573061006262 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 573061006263 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573061006264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006265 FeS/SAM binding site; other site 573061006266 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573061006267 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573061006268 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573061006269 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 573061006270 putative homotetramer interface [polypeptide binding]; other site 573061006271 putative homodimer interface [polypeptide binding]; other site 573061006272 putative allosteric switch controlling residues; other site 573061006273 putative metal binding site [ion binding]; other site 573061006274 putative homodimer-homodimer interface [polypeptide binding]; other site 573061006275 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 573061006276 putative homodimer interface [polypeptide binding]; other site 573061006277 putative homotetramer interface [polypeptide binding]; other site 573061006278 putative metal binding site [ion binding]; other site 573061006279 putative homodimer-homodimer interface [polypeptide binding]; other site 573061006280 putative allosteric switch controlling residues; other site 573061006281 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 573061006282 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573061006283 dimer interface [polypeptide binding]; other site 573061006284 motif 1; other site 573061006285 active site 573061006286 motif 2; other site 573061006287 motif 3; other site 573061006288 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573061006289 anticodon binding site; other site 573061006290 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 573061006291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006292 FeS/SAM binding site; other site 573061006293 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573061006294 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 573061006295 putative active site [active] 573061006296 dimerization interface [polypeptide binding]; other site 573061006297 putative tRNAtyr binding site [nucleotide binding]; other site 573061006298 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573061006299 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061006300 Zn2+ binding site [ion binding]; other site 573061006301 Mg2+ binding site [ion binding]; other site 573061006302 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573061006303 synthetase active site [active] 573061006304 NTP binding site [chemical binding]; other site 573061006305 metal binding site [ion binding]; metal-binding site 573061006306 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573061006307 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573061006308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061006309 active site 573061006310 DHH family; Region: DHH; pfam01368 573061006311 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 573061006312 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 573061006313 Protein export membrane protein; Region: SecD_SecF; pfam02355 573061006314 protein-export membrane protein SecD; Region: secD; TIGR01129 573061006315 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573061006316 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 573061006317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006318 FeS/SAM binding site; other site 573061006319 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061006320 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 573061006321 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 573061006322 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 573061006323 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573061006324 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573061006325 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 573061006326 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 573061006327 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573061006328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061006329 Walker A motif; other site 573061006330 ATP binding site [chemical binding]; other site 573061006331 Walker B motif; other site 573061006332 arginine finger; other site 573061006333 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573061006334 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 573061006335 RuvA N terminal domain; Region: RuvA_N; pfam01330 573061006336 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 573061006337 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061006338 active site 573061006339 catalytic triad [active] 573061006340 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573061006341 active site 573061006342 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 573061006343 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 573061006344 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 573061006345 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573061006346 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573061006347 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573061006348 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 573061006349 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 573061006350 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 573061006351 Peptidase family M50; Region: Peptidase_M50; pfam02163 573061006352 active site 573061006353 putative substrate binding region [chemical binding]; other site 573061006354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006355 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 573061006356 FeS/SAM binding site; other site 573061006357 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061006358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061006359 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061006360 Transglycosylase; Region: Transgly; pfam00912 573061006361 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 573061006362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573061006363 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 573061006364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061006365 active site 573061006366 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573061006367 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573061006368 HflX GTPase family; Region: HflX; cd01878 573061006369 G1 box; other site 573061006370 GTP/Mg2+ binding site [chemical binding]; other site 573061006371 Switch I region; other site 573061006372 G2 box; other site 573061006373 G3 box; other site 573061006374 Switch II region; other site 573061006375 G4 box; other site 573061006376 G5 box; other site 573061006377 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 573061006378 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 573061006379 stage V sporulation protein AD; Validated; Region: PRK08304 573061006380 stage V sporulation protein AD; Provisional; Region: PRK12404 573061006381 SpoVA protein; Region: SpoVA; cl04298 573061006382 sporulation sigma factor SigF; Validated; Region: PRK05572 573061006383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061006384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061006385 DNA binding residues [nucleotide binding] 573061006386 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 573061006387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061006388 ATP binding site [chemical binding]; other site 573061006389 Mg2+ binding site [ion binding]; other site 573061006390 G-X-G motif; other site 573061006391 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573061006392 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573061006393 anti sigma factor interaction site; other site 573061006394 regulatory phosphorylation site [posttranslational modification]; other site 573061006395 spermidine synthase; Provisional; Region: PRK00811 573061006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061006397 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573061006398 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 573061006399 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 573061006400 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 573061006401 NodB motif; other site 573061006402 active site 573061006403 catalytic site [active] 573061006404 Cd binding site [ion binding]; other site 573061006405 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 573061006406 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 573061006407 putative FMN binding site [chemical binding]; other site 573061006408 integral membrane protein MviN; Region: mviN; TIGR01695 573061006409 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573061006410 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573061006411 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573061006412 NADP binding site [chemical binding]; other site 573061006413 active site 573061006414 putative substrate binding site [chemical binding]; other site 573061006415 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 573061006416 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 573061006417 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573061006418 O-Antigen ligase; Region: Wzy_C; pfam04932 573061006419 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573061006420 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 573061006421 active site 573061006422 tetramer interface; other site 573061006423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006424 TPR motif; other site 573061006425 binding surface 573061006426 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573061006427 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 573061006428 active site 573061006429 substrate binding site [chemical binding]; other site 573061006430 metal binding site [ion binding]; metal-binding site 573061006431 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 573061006432 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573061006433 homodimer interface [polypeptide binding]; other site 573061006434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006435 catalytic residue [active] 573061006436 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573061006437 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 573061006438 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573061006439 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573061006440 Peptidase M16C associated; Region: M16C_assoc; pfam08367 573061006441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006442 binding surface 573061006443 TPR motif; other site 573061006444 TPR repeat; Region: TPR_11; pfam13414 573061006445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006446 TPR repeat; Region: TPR_11; pfam13414 573061006447 binding surface 573061006448 TPR motif; other site 573061006449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006451 binding surface 573061006452 TPR motif; other site 573061006453 TPR repeat; Region: TPR_11; pfam13414 573061006454 Protein of unknown function (DUF523); Region: DUF523; pfam04463 573061006455 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 573061006456 MutS domain III; Region: MutS_III; pfam05192 573061006457 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 573061006458 Walker A/P-loop; other site 573061006459 ATP binding site [chemical binding]; other site 573061006460 Q-loop/lid; other site 573061006461 ABC transporter signature motif; other site 573061006462 Walker B; other site 573061006463 D-loop; other site 573061006464 H-loop/switch region; other site 573061006465 Smr domain; Region: Smr; pfam01713 573061006466 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573061006467 Peptidase family U32; Region: Peptidase_U32; pfam01136 573061006468 Collagenase; Region: DUF3656; pfam12392 573061006469 Peptidase family U32; Region: Peptidase_U32; cl03113 573061006470 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061006471 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 573061006472 NodB motif; other site 573061006473 active site 573061006474 catalytic site [active] 573061006475 Zn binding site [ion binding]; other site 573061006476 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 573061006477 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061006478 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 573061006479 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 573061006480 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 573061006481 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 573061006482 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 573061006483 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573061006484 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573061006485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061006486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006487 homodimer interface [polypeptide binding]; other site 573061006488 catalytic residue [active] 573061006489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061006490 Coenzyme A binding pocket [chemical binding]; other site 573061006491 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573061006492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061006493 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 573061006494 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK12360 573061006495 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 573061006496 cytidylate kinase; Provisional; Region: cmk; PRK00023 573061006497 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573061006498 CMP-binding site; other site 573061006499 The sites determining sugar specificity; other site 573061006500 HI0933-like protein; Region: HI0933_like; pfam03486 573061006501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573061006502 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573061006503 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573061006504 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573061006505 putative active site [active] 573061006506 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 573061006507 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573061006508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061006509 RNA binding surface [nucleotide binding]; other site 573061006510 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 573061006511 active site 573061006512 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 573061006513 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573061006514 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573061006515 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573061006516 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 573061006517 feedback inhibition sensing region; other site 573061006518 homohexameric interface [polypeptide binding]; other site 573061006519 nucleotide binding site [chemical binding]; other site 573061006520 N-acetyl-L-glutamate binding site [chemical binding]; other site 573061006521 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 573061006522 Homoserine O-succinyltransferase; Region: HTS; pfam04204 573061006523 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 573061006524 proposed active site lysine [active] 573061006525 conserved cys residue [active] 573061006526 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 573061006527 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 573061006528 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573061006529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061006530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061006531 dimer interface [polypeptide binding]; other site 573061006532 phosphorylation site [posttranslational modification] 573061006533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061006534 ATP binding site [chemical binding]; other site 573061006535 Mg2+ binding site [ion binding]; other site 573061006536 G-X-G motif; other site 573061006537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061006538 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061006539 2-isopropylmalate synthase; Validated; Region: PRK03739 573061006540 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 573061006541 active site 573061006542 catalytic residues [active] 573061006543 metal binding site [ion binding]; metal-binding site 573061006544 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573061006545 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573061006546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061006547 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573061006548 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573061006549 putative tRNA-binding site [nucleotide binding]; other site 573061006550 B3/4 domain; Region: B3_4; pfam03483 573061006551 tRNA synthetase B5 domain; Region: B5; smart00874 573061006552 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573061006553 dimer interface [polypeptide binding]; other site 573061006554 motif 1; other site 573061006555 motif 3; other site 573061006556 motif 2; other site 573061006557 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 573061006558 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573061006559 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573061006560 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573061006561 dimer interface [polypeptide binding]; other site 573061006562 motif 1; other site 573061006563 active site 573061006564 motif 2; other site 573061006565 motif 3; other site 573061006566 anthranilate synthase; Provisional; Region: PRK13566 573061006567 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573061006568 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573061006569 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573061006570 glutamine binding [chemical binding]; other site 573061006571 catalytic triad [active] 573061006572 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 573061006573 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573061006574 substrate binding site [chemical binding]; other site 573061006575 active site 573061006576 catalytic residues [active] 573061006577 heterodimer interface [polypeptide binding]; other site 573061006578 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573061006579 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573061006580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006581 catalytic residue [active] 573061006582 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573061006583 active site 573061006584 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573061006585 active site 573061006586 ribulose/triose binding site [chemical binding]; other site 573061006587 phosphate binding site [ion binding]; other site 573061006588 substrate (anthranilate) binding pocket [chemical binding]; other site 573061006589 product (indole) binding pocket [chemical binding]; other site 573061006590 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 573061006591 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573061006592 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573061006593 Quinolinate synthetase A protein; Region: NadA; pfam02445 573061006594 L-aspartate oxidase; Provisional; Region: PRK06175 573061006595 FAD binding domain; Region: FAD_binding_2; pfam00890 573061006596 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 573061006597 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 573061006598 dimerization interface [polypeptide binding]; other site 573061006599 active site 573061006600 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 573061006601 HEAT-like repeat; Region: HEAT_EZ; pfam13513 573061006602 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 573061006603 Uncharacterized conserved protein [Function unknown]; Region: COG1739 573061006604 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 573061006605 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 573061006606 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573061006607 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573061006608 active site 573061006609 metal binding site [ion binding]; metal-binding site 573061006610 Sporulation related domain; Region: SPOR; cl10051 573061006611 NTPase; Region: NTPase_1; cl17478 573061006612 hypothetical protein; Validated; Region: PRK00110 573061006613 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 573061006614 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 573061006615 Cache domain; Region: Cache_1; pfam02743 573061006616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061006617 dimerization interface [polypeptide binding]; other site 573061006618 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061006619 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061006620 dimer interface [polypeptide binding]; other site 573061006621 putative CheW interface [polypeptide binding]; other site 573061006622 Stage II sporulation protein; Region: SpoIID; pfam08486 573061006623 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061006624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061006625 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573061006626 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573061006627 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 573061006628 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 573061006629 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 573061006630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061006631 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061006632 Coenzyme A binding pocket [chemical binding]; other site 573061006633 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 573061006634 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 573061006635 Low molecular weight phosphatase family; Region: LMWPc; cl00105 573061006636 active site 573061006637 GGGtGRT protein; Region: GGGtGRT; pfam14057 573061006638 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573061006639 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 573061006640 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061006641 Aegerolysin; Region: Aegerolysin; pfam06355 573061006642 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 573061006643 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573061006644 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 573061006645 dockerin binding interface; other site 573061006646 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 573061006647 ligand binding site; other site 573061006648 tetramer interface; other site 573061006649 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573061006650 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573061006651 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573061006652 MviN-like protein; Region: MVIN; pfam03023 573061006653 Protein of unknown function DUF70; Region: DUF70; cl00785 573061006654 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573061006655 catalytic triad [active] 573061006656 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061006657 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061006658 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 573061006659 putative ADP-binding pocket [chemical binding]; other site 573061006660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573061006661 catalytic core [active] 573061006662 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 573061006663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573061006664 inhibitor-cofactor binding pocket; inhibition site 573061006665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006666 catalytic residue [active] 573061006667 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 573061006668 dimer interface [polypeptide binding]; other site 573061006669 active site 573061006670 Schiff base residues; other site 573061006671 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 573061006672 active site 573061006673 SAM binding site [chemical binding]; other site 573061006674 homodimer interface [polypeptide binding]; other site 573061006675 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 573061006676 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 573061006677 active site 573061006678 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 573061006679 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 573061006680 domain interfaces; other site 573061006681 active site 573061006682 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 573061006683 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 573061006684 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 573061006685 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 573061006686 tRNA; other site 573061006687 putative tRNA binding site [nucleotide binding]; other site 573061006688 putative NADP binding site [chemical binding]; other site 573061006689 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 573061006690 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 573061006691 putative dimer interface [polypeptide binding]; other site 573061006692 active site pocket [active] 573061006693 putative cataytic base [active] 573061006694 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573061006695 catalytic core [active] 573061006696 cobalamin synthase; Reviewed; Region: cobS; PRK00235 573061006697 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 573061006698 Precorrin-8X methylmutase; Region: CbiC; pfam02570 573061006699 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 573061006700 cobyric acid synthase; Provisional; Region: PRK00784 573061006701 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061006702 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061006703 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 573061006704 catalytic triad [active] 573061006705 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 573061006706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061006707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061006708 homodimer interface [polypeptide binding]; other site 573061006709 catalytic residue [active] 573061006710 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573061006711 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 573061006712 Walker A/P-loop; other site 573061006713 ATP binding site [chemical binding]; other site 573061006714 Q-loop/lid; other site 573061006715 ABC transporter signature motif; other site 573061006716 Walker B; other site 573061006717 D-loop; other site 573061006718 H-loop/switch region; other site 573061006719 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 573061006720 cobalt transport protein CbiN; Provisional; Region: PRK02898 573061006721 cobalt transport protein CbiM; Validated; Region: PRK08319 573061006722 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 573061006723 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 573061006724 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 573061006725 active site 573061006726 SAM binding site [chemical binding]; other site 573061006727 homodimer interface [polypeptide binding]; other site 573061006728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061006729 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 573061006730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 573061006731 catalytic triad [active] 573061006732 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 573061006733 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 573061006734 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 573061006735 putative active site [active] 573061006736 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 573061006737 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 573061006738 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 573061006739 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 573061006740 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 573061006741 active site 573061006742 SAM binding site [chemical binding]; other site 573061006743 homodimer interface [polypeptide binding]; other site 573061006744 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 573061006745 active site 573061006746 SAM binding site [chemical binding]; other site 573061006747 homodimer interface [polypeptide binding]; other site 573061006748 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 573061006749 active site 573061006750 putative homodimer interface [polypeptide binding]; other site 573061006751 SAM binding site [chemical binding]; other site 573061006752 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 573061006753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061006754 S-adenosylmethionine binding site [chemical binding]; other site 573061006755 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 573061006756 Nitroreductase family; Region: Nitroreductase; pfam00881 573061006757 FMN binding site [chemical binding]; other site 573061006758 dimer interface [polypeptide binding]; other site 573061006759 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061006760 dimer interface [polypeptide binding]; other site 573061006761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061006762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061006763 dimerization interface [polypeptide binding]; other site 573061006764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061006765 dimer interface [polypeptide binding]; other site 573061006766 phosphorylation site [posttranslational modification] 573061006767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061006768 ATP binding site [chemical binding]; other site 573061006769 Mg2+ binding site [ion binding]; other site 573061006770 G-X-G motif; other site 573061006771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061006772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061006773 active site 573061006774 phosphorylation site [posttranslational modification] 573061006775 intermolecular recognition site; other site 573061006776 dimerization interface [polypeptide binding]; other site 573061006777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061006778 DNA binding site [nucleotide binding] 573061006779 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573061006780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006781 FeS/SAM binding site; other site 573061006782 flavodoxin; Provisional; Region: PRK06242 573061006783 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 573061006784 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 573061006785 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573061006786 substrate binding site [chemical binding]; other site 573061006787 trimer interface [polypeptide binding]; other site 573061006788 Mn binding site [ion binding]; other site 573061006789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061006790 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061006791 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061006792 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 573061006793 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573061006794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573061006795 catalytic loop [active] 573061006796 iron binding site [ion binding]; other site 573061006797 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573061006798 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573061006799 4Fe-4S binding domain; Region: Fer4; pfam00037 573061006800 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573061006801 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573061006802 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573061006803 dimer interface [polypeptide binding]; other site 573061006804 [2Fe-2S] cluster binding site [ion binding]; other site 573061006805 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573061006806 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573061006807 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061006808 4Fe-4S binding domain; Region: Fer4; pfam00037 573061006809 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 573061006810 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573061006811 putative dimer interface [polypeptide binding]; other site 573061006812 [2Fe-2S] cluster binding site [ion binding]; other site 573061006813 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573061006814 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 573061006815 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 573061006816 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573061006817 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 573061006818 putative L-serine binding site [chemical binding]; other site 573061006819 Isochorismatase family; Region: Isochorismatase; pfam00857 573061006820 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 573061006821 catalytic triad [active] 573061006822 conserved cis-peptide bond; other site 573061006823 Glucuronate isomerase; Region: UxaC; pfam02614 573061006824 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 573061006825 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573061006826 galactarate dehydratase; Region: galactar-dH20; TIGR03248 573061006827 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573061006828 altronate oxidoreductase; Provisional; Region: PRK03643 573061006829 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573061006830 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573061006831 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061006832 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 573061006833 putative active site [active] 573061006834 putative metal binding site [ion binding]; other site 573061006835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573061006836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061006837 DNA-binding site [nucleotide binding]; DNA binding site 573061006838 FCD domain; Region: FCD; pfam07729 573061006839 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 573061006840 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 573061006841 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573061006842 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573061006843 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 573061006844 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573061006845 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573061006846 Metal-binding active site; metal-binding site 573061006847 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 573061006848 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573061006849 active site 573061006850 intersubunit interface [polypeptide binding]; other site 573061006851 catalytic residue [active] 573061006852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573061006853 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573061006854 substrate binding site [chemical binding]; other site 573061006855 ATP binding site [chemical binding]; other site 573061006856 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 573061006857 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573061006858 NADP binding site [chemical binding]; other site 573061006859 homodimer interface [polypeptide binding]; other site 573061006860 active site 573061006861 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 573061006862 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573061006863 NADP binding site [chemical binding]; other site 573061006864 homodimer interface [polypeptide binding]; other site 573061006865 active site 573061006866 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573061006867 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573061006868 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573061006869 Bacterial transcriptional regulator; Region: IclR; pfam01614 573061006870 EamA-like transporter family; Region: EamA; pfam00892 573061006871 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573061006872 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573061006873 AP (apurinic/apyrimidinic) site pocket; other site 573061006874 Metal-binding active site; metal-binding site 573061006875 Predicted membrane protein [Function unknown]; Region: COG2364 573061006876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061006877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061006878 non-specific DNA binding site [nucleotide binding]; other site 573061006879 salt bridge; other site 573061006880 sequence-specific DNA binding site [nucleotide binding]; other site 573061006881 Cupin domain; Region: Cupin_2; pfam07883 573061006882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061006883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061006884 non-specific DNA binding site [nucleotide binding]; other site 573061006885 salt bridge; other site 573061006886 sequence-specific DNA binding site [nucleotide binding]; other site 573061006887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061006888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061006889 non-specific DNA binding site [nucleotide binding]; other site 573061006890 salt bridge; other site 573061006891 sequence-specific DNA binding site [nucleotide binding]; other site 573061006892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061006893 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061006894 acyl-activating enzyme (AAE) consensus motif; other site 573061006895 AMP binding site [chemical binding]; other site 573061006896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061006897 B12 binding domain; Region: B12-binding; pfam02310 573061006898 B12 binding site [chemical binding]; other site 573061006899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061006900 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573061006901 FeS/SAM binding site; other site 573061006902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061006903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061006904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061006905 Walker A/P-loop; other site 573061006906 ATP binding site [chemical binding]; other site 573061006907 Q-loop/lid; other site 573061006908 ABC transporter signature motif; other site 573061006909 Walker B; other site 573061006910 D-loop; other site 573061006911 H-loop/switch region; other site 573061006912 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061006913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061006914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061006915 Walker A/P-loop; other site 573061006916 ATP binding site [chemical binding]; other site 573061006917 Q-loop/lid; other site 573061006918 ABC transporter signature motif; other site 573061006919 Walker B; other site 573061006920 D-loop; other site 573061006921 H-loop/switch region; other site 573061006922 TIR domain; Region: TIR_2; pfam13676 573061006923 AAA ATPase domain; Region: AAA_16; pfam13191 573061006924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573061006925 binding surface 573061006926 TPR motif; other site 573061006927 TIR domain; Region: TIR_2; pfam13676 573061006928 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006930 binding surface 573061006931 TPR motif; other site 573061006932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006935 binding surface 573061006936 TPR motif; other site 573061006937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006939 binding surface 573061006940 TPR motif; other site 573061006941 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061006944 binding surface 573061006945 TPR motif; other site 573061006946 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006947 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061006948 SIR2-like domain; Region: SIR2_2; pfam13289 573061006949 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 573061006950 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061006951 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061006952 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061006953 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573061006954 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573061006955 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061006956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061006957 active site 573061006958 phosphorylation site [posttranslational modification] 573061006959 intermolecular recognition site; other site 573061006960 dimerization interface [polypeptide binding]; other site 573061006961 LytTr DNA-binding domain; Region: LytTR; smart00850 573061006962 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573061006963 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 573061006964 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 573061006965 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 573061006966 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 573061006967 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061006968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061006969 non-specific DNA binding site [nucleotide binding]; other site 573061006970 salt bridge; other site 573061006971 sequence-specific DNA binding site [nucleotide binding]; other site 573061006972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573061006973 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 573061006974 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 573061006975 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 573061006976 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 573061006977 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 573061006978 GTP-binding protein; Provisional; Region: PTZ00258 573061006979 digalactosyldiacylglycerol synthase; Region: PLN02501 573061006980 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061006981 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 573061006982 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573061006983 Walker A motif; other site 573061006984 ATP binding site [chemical binding]; other site 573061006985 Walker B motif; other site 573061006986 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 573061006987 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 573061006988 CHC2 zinc finger; Region: zf-CHC2; cl17510 573061006989 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 573061006990 Toprim-like; Region: Toprim_2; pfam13155 573061006991 active site 573061006992 metal binding site [ion binding]; metal-binding site 573061006993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061006994 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573061006995 dimer interface [polypeptide binding]; other site 573061006996 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 573061006997 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 573061006998 putative active site [active] 573061006999 putative NTP binding site [chemical binding]; other site 573061007000 putative nucleic acid binding site [nucleotide binding]; other site 573061007001 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 573061007002 Type II intron maturase; Region: Intron_maturas2; pfam01348 573061007003 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061007004 active site 573061007005 ParB-like nuclease domain; Region: ParB; smart00470 573061007006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573061007007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573061007008 P-loop; other site 573061007009 Magnesium ion binding site [ion binding]; other site 573061007010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061007011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061007012 non-specific DNA binding site [nucleotide binding]; other site 573061007013 salt bridge; other site 573061007014 sequence-specific DNA binding site [nucleotide binding]; other site 573061007015 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007016 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007017 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007018 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007019 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007020 potential frameshift: common BLAST hit: gi|71736991|ref|YP_273097.1| calcium binding hemolysin protein, putative 573061007021 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007022 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007023 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007024 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007025 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007026 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 573061007027 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007028 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007029 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007030 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 573061007031 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007032 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007033 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007034 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007035 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007036 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007037 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007038 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007039 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007040 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007041 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007042 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061007043 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573061007044 catalytic residues [active] 573061007045 catalytic nucleophile [active] 573061007046 Presynaptic Site I dimer interface [polypeptide binding]; other site 573061007047 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573061007048 Synaptic Flat tetramer interface [polypeptide binding]; other site 573061007049 Synaptic Site I dimer interface [polypeptide binding]; other site 573061007050 DNA binding site [nucleotide binding] 573061007051 Recombinase; Region: Recombinase; pfam07508 573061007052 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061007053 Glucose inhibited division protein A; Region: GIDA; pfam01134 573061007054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061007055 hypothetical protein; Provisional; Region: PRK05802 573061007056 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 573061007057 FAD binding pocket [chemical binding]; other site 573061007058 FAD binding motif [chemical binding]; other site 573061007059 phosphate binding motif [ion binding]; other site 573061007060 beta-alpha-beta structure motif; other site 573061007061 NAD binding pocket [chemical binding]; other site 573061007062 Iron coordination center [ion binding]; other site 573061007063 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 573061007064 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573061007065 active site 573061007066 NTP binding site [chemical binding]; other site 573061007067 metal binding triad [ion binding]; metal-binding site 573061007068 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573061007069 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 573061007070 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 573061007071 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573061007072 active site 573061007073 homodimer interface [polypeptide binding]; other site 573061007074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061007075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061007076 dimer interface [polypeptide binding]; other site 573061007077 phosphorylation site [posttranslational modification] 573061007078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007079 ATP binding site [chemical binding]; other site 573061007080 Mg2+ binding site [ion binding]; other site 573061007081 G-X-G motif; other site 573061007082 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 573061007083 DHH family; Region: DHH; pfam01368 573061007084 DHHA1 domain; Region: DHHA1; pfam02272 573061007085 biotin synthase; Provisional; Region: PRK07094 573061007086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061007087 FeS/SAM binding site; other site 573061007088 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 573061007089 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 573061007090 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061007091 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573061007092 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573061007093 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573061007094 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573061007095 DJ-1 family protein; Region: not_thiJ; TIGR01383 573061007096 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 573061007097 conserved cys residue [active] 573061007098 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 573061007099 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573061007100 CAP-like domain; other site 573061007101 active site 573061007102 primary dimer interface [polypeptide binding]; other site 573061007103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061007104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573061007105 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 573061007106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007107 ATP binding site [chemical binding]; other site 573061007108 Mg2+ binding site [ion binding]; other site 573061007109 G-X-G motif; other site 573061007110 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573061007111 anchoring element; other site 573061007112 dimer interface [polypeptide binding]; other site 573061007113 ATP binding site [chemical binding]; other site 573061007114 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573061007115 active site 573061007116 metal binding site [ion binding]; metal-binding site 573061007117 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573061007118 flagellin; Provisional; Region: PRK12804 573061007119 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061007120 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061007121 flagellin; Provisional; Region: PRK12804 573061007122 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061007123 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061007124 flagellin; Provisional; Region: PRK12804 573061007125 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061007126 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061007127 flagellin; Provisional; Region: PRK12804 573061007128 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061007129 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061007130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061007131 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061007132 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 573061007133 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573061007134 active site 573061007135 homodimer interface [polypeptide binding]; other site 573061007136 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 573061007137 NeuB family; Region: NeuB; pfam03102 573061007138 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 573061007139 NeuB binding interface [polypeptide binding]; other site 573061007140 putative substrate binding site [chemical binding]; other site 573061007141 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 573061007142 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 573061007143 putative trimer interface [polypeptide binding]; other site 573061007144 putative CoA binding site [chemical binding]; other site 573061007145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 573061007146 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 573061007147 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573061007148 Substrate binding site; other site 573061007149 metal-binding site 573061007150 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 573061007151 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573061007152 inhibitor-cofactor binding pocket; inhibition site 573061007153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061007154 catalytic residue [active] 573061007155 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 573061007156 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 573061007157 NAD binding site [chemical binding]; other site 573061007158 substrate binding site [chemical binding]; other site 573061007159 active site 573061007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 573061007161 Acylphosphatase; Region: Acylphosphatase; cl00551 573061007162 Rrf2 family protein; Region: rrf2_super; TIGR00738 573061007163 Transcriptional regulator; Region: Rrf2; pfam02082 573061007164 Uncharacterized conserved protein [Function unknown]; Region: COG3287 573061007165 FIST N domain; Region: FIST; pfam08495 573061007166 FIST C domain; Region: FIST_C; pfam10442 573061007167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061007168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007169 dimer interface [polypeptide binding]; other site 573061007170 putative CheW interface [polypeptide binding]; other site 573061007171 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573061007172 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573061007173 Ligand binding site; other site 573061007174 Putative Catalytic site; other site 573061007175 DXD motif; other site 573061007176 GtrA-like protein; Region: GtrA; pfam04138 573061007177 Predicted periplasmic protein [Function unknown]; Region: COG3698 573061007178 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 573061007179 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 573061007180 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 573061007181 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 573061007182 putative catalytic cysteine [active] 573061007183 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 573061007184 putative active site [active] 573061007185 metal binding site [ion binding]; metal-binding site 573061007186 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573061007187 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573061007188 glutaminase active site [active] 573061007189 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573061007190 dimer interface [polypeptide binding]; other site 573061007191 active site 573061007192 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573061007193 dimer interface [polypeptide binding]; other site 573061007194 active site 573061007195 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 573061007196 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 573061007197 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 573061007198 active site 573061007199 P-loop; other site 573061007200 phosphorylation site [posttranslational modification] 573061007201 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 573061007202 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573061007203 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573061007204 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573061007205 active site 573061007206 phosphorylation site [posttranslational modification] 573061007207 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 573061007208 PRD domain; Region: PRD; pfam00874 573061007209 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 573061007210 active site 573061007211 P-loop; other site 573061007212 phosphorylation site [posttranslational modification] 573061007213 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 573061007214 active site 573061007215 phosphorylation site [posttranslational modification] 573061007216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061007217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061007218 Coenzyme A binding pocket [chemical binding]; other site 573061007219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061007220 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573061007221 active site 573061007222 motif I; other site 573061007223 motif II; other site 573061007224 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061007225 adenosine deaminase; Provisional; Region: PRK09358 573061007226 active site 573061007227 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 573061007228 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 573061007229 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573061007230 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573061007231 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 573061007232 Fasciclin domain; Region: Fasciclin; pfam02469 573061007233 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 573061007234 T5orf172 domain; Region: T5orf172; pfam10544 573061007235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061007236 ATP binding site [chemical binding]; other site 573061007237 putative Mg++ binding site [ion binding]; other site 573061007238 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573061007239 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 573061007240 active site 573061007241 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573061007242 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573061007243 amidase catalytic site [active] 573061007244 Zn binding residues [ion binding]; other site 573061007245 substrate binding site [chemical binding]; other site 573061007246 Sporulation related domain; Region: SPOR; pfam05036 573061007247 Holin family; Region: Phage_holin_4; cl01989 573061007248 Phage tail protein; Region: Sipho_tail; pfam05709 573061007249 Phage-related minor tail protein [Function unknown]; Region: COG5280 573061007250 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 573061007251 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 573061007252 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573061007253 Phage capsid family; Region: Phage_capsid; pfam05065 573061007254 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573061007255 Phage portal protein; Region: Phage_portal; pfam04860 573061007256 Phage-related protein [Function unknown]; Region: COG4695; cl01923 573061007257 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573061007258 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573061007259 active site 573061007260 DNA binding site [nucleotide binding] 573061007261 Int/Topo IB signature motif; other site 573061007262 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 573061007263 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 573061007264 replicative DNA helicase; Region: DnaB; TIGR00665 573061007265 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573061007266 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573061007267 Walker A motif; other site 573061007268 ATP binding site [chemical binding]; other site 573061007269 Walker B motif; other site 573061007270 DNA binding loops [nucleotide binding] 573061007271 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 573061007272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061007273 non-specific DNA binding site [nucleotide binding]; other site 573061007274 salt bridge; other site 573061007275 sequence-specific DNA binding site [nucleotide binding]; other site 573061007276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061007277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061007278 non-specific DNA binding site [nucleotide binding]; other site 573061007279 salt bridge; other site 573061007280 sequence-specific DNA binding site [nucleotide binding]; other site 573061007281 Domain of unknown function (DUF955); Region: DUF955; pfam06114 573061007282 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 573061007283 Int/Topo IB signature motif; other site 573061007284 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 573061007285 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 573061007286 active site 573061007287 metal binding site [ion binding]; metal-binding site 573061007288 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573061007289 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 573061007290 active site 573061007291 metal binding site [ion binding]; metal-binding site 573061007292 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573061007293 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061007294 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061007295 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573061007296 Walker A/P-loop; other site 573061007297 ATP binding site [chemical binding]; other site 573061007298 Q-loop/lid; other site 573061007299 ABC transporter signature motif; other site 573061007300 Walker B; other site 573061007301 D-loop; other site 573061007302 H-loop/switch region; other site 573061007303 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 573061007304 Protein of unknown function DUF58; Region: DUF58; pfam01882 573061007305 MoxR-like ATPases [General function prediction only]; Region: COG0714 573061007306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061007307 ATP binding site [chemical binding]; other site 573061007308 Walker A motif; other site 573061007309 Walker B motif; other site 573061007310 arginine finger; other site 573061007311 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007312 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007313 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007314 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007315 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061007316 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007317 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007318 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061007319 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 573061007320 active site 573061007321 metal binding site [ion binding]; metal-binding site 573061007322 homotetramer interface [polypeptide binding]; other site 573061007323 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 573061007324 nucleophile elbow; other site 573061007325 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 573061007326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061007327 Walker A/P-loop; other site 573061007328 ATP binding site [chemical binding]; other site 573061007329 Q-loop/lid; other site 573061007330 ABC transporter signature motif; other site 573061007331 Walker B; other site 573061007332 D-loop; other site 573061007333 H-loop/switch region; other site 573061007334 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 573061007335 isocitrate dehydrogenase; Validated; Region: PRK06451 573061007336 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 573061007337 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 573061007338 active site 573061007339 catalytic residues [active] 573061007340 metal binding site [ion binding]; metal-binding site 573061007341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573061007342 catalytic core [active] 573061007343 Protein of unknown function (DUF402); Region: DUF402; cl00979 573061007344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061007345 FeS/SAM binding site; other site 573061007346 Elongation factor TS; Region: EF_TS; pfam00889 573061007347 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 573061007348 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 573061007349 GTP/Mg2+ binding site [chemical binding]; other site 573061007350 G5 box; other site 573061007351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061007352 AAA domain; Region: AAA_18; pfam13238 573061007353 G1 box; other site 573061007354 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573061007355 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573061007356 dimer interface [polypeptide binding]; other site 573061007357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061007358 catalytic residue [active] 573061007359 Predicted transcriptional regulator [Transcription]; Region: COG1959 573061007360 Transcriptional regulator; Region: Rrf2; pfam02082 573061007361 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 573061007362 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 573061007363 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 573061007364 Ligand Binding Site [chemical binding]; other site 573061007365 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573061007366 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573061007367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061007368 catalytic residue [active] 573061007369 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573061007370 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061007371 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061007372 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573061007373 TraX protein; Region: TraX; pfam05857 573061007374 Condensation domain; Region: Condensation; pfam00668 573061007375 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007376 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007377 acyl-activating enzyme (AAE) consensus motif; other site 573061007378 AMP binding site [chemical binding]; other site 573061007379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007380 Condensation domain; Region: Condensation; pfam00668 573061007381 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007382 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007383 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007384 acyl-activating enzyme (AAE) consensus motif; other site 573061007385 AMP binding site [chemical binding]; other site 573061007386 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007387 Condensation domain; Region: Condensation; pfam00668 573061007388 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007389 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007390 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007391 acyl-activating enzyme (AAE) consensus motif; other site 573061007392 AMP binding site [chemical binding]; other site 573061007393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007394 Condensation domain; Region: Condensation; pfam00668 573061007395 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007396 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007397 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007398 acyl-activating enzyme (AAE) consensus motif; other site 573061007399 AMP binding site [chemical binding]; other site 573061007400 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007401 Condensation domain; Region: Condensation; pfam00668 573061007402 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007403 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007404 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007405 acyl-activating enzyme (AAE) consensus motif; other site 573061007406 AMP binding site [chemical binding]; other site 573061007407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007408 Condensation domain; Region: Condensation; pfam00668 573061007409 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007410 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007411 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007412 acyl-activating enzyme (AAE) consensus motif; other site 573061007413 AMP binding site [chemical binding]; other site 573061007414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007415 Condensation domain; Region: Condensation; pfam00668 573061007416 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007417 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007418 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007419 acyl-activating enzyme (AAE) consensus motif; other site 573061007420 AMP binding site [chemical binding]; other site 573061007421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007422 Condensation domain; Region: Condensation; pfam00668 573061007423 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007424 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007425 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061007426 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061007427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007428 acyl-activating enzyme (AAE) consensus motif; other site 573061007429 AMP binding site [chemical binding]; other site 573061007430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007431 Condensation domain; Region: Condensation; pfam00668 573061007432 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007433 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007434 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061007435 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007436 acyl-activating enzyme (AAE) consensus motif; other site 573061007437 AMP binding site [chemical binding]; other site 573061007438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007439 Thioesterase domain; Region: Thioesterase; pfam00975 573061007440 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 573061007441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573061007442 inhibitor-cofactor binding pocket; inhibition site 573061007443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061007444 catalytic residue [active] 573061007445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061007446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061007447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061007448 Walker A/P-loop; other site 573061007449 ATP binding site [chemical binding]; other site 573061007450 Q-loop/lid; other site 573061007451 ABC transporter signature motif; other site 573061007452 Walker B; other site 573061007453 D-loop; other site 573061007454 H-loop/switch region; other site 573061007455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061007456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061007457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061007458 Walker A/P-loop; other site 573061007459 ATP binding site [chemical binding]; other site 573061007460 Q-loop/lid; other site 573061007461 ABC transporter signature motif; other site 573061007462 Walker B; other site 573061007463 D-loop; other site 573061007464 H-loop/switch region; other site 573061007465 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007466 AMP binding site [chemical binding]; other site 573061007467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007468 Condensation domain; Region: Condensation; pfam00668 573061007469 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007470 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061007472 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007473 acyl-activating enzyme (AAE) consensus motif; other site 573061007474 AMP binding site [chemical binding]; other site 573061007475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007476 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 573061007477 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007478 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061007479 acyl-activating enzyme (AAE) consensus motif; other site 573061007480 AMP binding site [chemical binding]; other site 573061007481 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007482 Condensation domain; Region: Condensation; pfam00668 573061007483 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007484 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007485 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 573061007486 acyl-activating enzyme (AAE) consensus motif; other site 573061007487 AMP binding site [chemical binding]; other site 573061007488 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007489 Condensation domain; Region: Condensation; pfam00668 573061007490 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007491 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007492 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007493 acyl-activating enzyme (AAE) consensus motif; other site 573061007494 AMP binding site [chemical binding]; other site 573061007495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007496 Condensation domain; Region: Condensation; pfam00668 573061007497 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007498 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007499 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 573061007500 acyl-activating enzyme (AAE) consensus motif; other site 573061007501 AMP binding site [chemical binding]; other site 573061007502 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007503 Condensation domain; Region: Condensation; pfam00668 573061007504 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007505 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061007507 acyl-activating enzyme (AAE) consensus motif; other site 573061007508 Condensation domain; Region: Condensation; pfam00668 573061007509 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007510 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007511 acyl-activating enzyme (AAE) consensus motif; other site 573061007512 AMP binding site [chemical binding]; other site 573061007513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007514 Condensation domain; Region: Condensation; pfam00668 573061007515 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007516 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007517 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007518 acyl-activating enzyme (AAE) consensus motif; other site 573061007519 AMP binding site [chemical binding]; other site 573061007520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007521 Condensation domain; Region: Condensation; pfam00668 573061007522 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007523 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 573061007524 acyl-activating enzyme (AAE) consensus motif; other site 573061007525 putative AMP binding site [chemical binding]; other site 573061007526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007527 Condensation domain; Region: Condensation; pfam00668 573061007528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007529 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007530 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007531 acyl-activating enzyme (AAE) consensus motif; other site 573061007532 AMP binding site [chemical binding]; other site 573061007533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007534 Condensation domain; Region: Condensation; pfam00668 573061007535 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007536 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061007537 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061007538 acyl-activating enzyme (AAE) consensus motif; other site 573061007539 AMP binding site [chemical binding]; other site 573061007540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061007541 Condensation domain; Region: Condensation; pfam00668 573061007542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061007543 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 573061007544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061007545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061007546 dimerization interface [polypeptide binding]; other site 573061007547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061007548 dimer interface [polypeptide binding]; other site 573061007549 phosphorylation site [posttranslational modification] 573061007550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007551 ATP binding site [chemical binding]; other site 573061007552 Mg2+ binding site [ion binding]; other site 573061007553 G-X-G motif; other site 573061007554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061007555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007556 active site 573061007557 phosphorylation site [posttranslational modification] 573061007558 intermolecular recognition site; other site 573061007559 dimerization interface [polypeptide binding]; other site 573061007560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061007561 DNA binding site [nucleotide binding] 573061007562 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061007563 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061007564 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061007565 FMN-binding domain; Region: FMN_bind; cl01081 573061007566 FMN-binding domain; Region: FMN_bind; cl01081 573061007567 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 573061007568 ApbE family; Region: ApbE; pfam02424 573061007569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061007570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061007571 metal binding site [ion binding]; metal-binding site 573061007572 active site 573061007573 I-site; other site 573061007574 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573061007575 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573061007576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007577 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007578 active site 573061007579 phosphorylation site [posttranslational modification] 573061007580 intermolecular recognition site; other site 573061007581 dimerization interface [polypeptide binding]; other site 573061007582 Predicted membrane protein [Function unknown]; Region: COG1511 573061007583 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 573061007584 Predicted membrane protein [Function unknown]; Region: COG1511 573061007585 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 573061007586 Predicted membrane protein [Function unknown]; Region: COG2323 573061007587 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 573061007588 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061007589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061007590 dimerization interface [polypeptide binding]; other site 573061007591 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007592 dimer interface [polypeptide binding]; other site 573061007593 putative CheW interface [polypeptide binding]; other site 573061007594 threonine dehydratase; Provisional; Region: PRK08198 573061007595 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573061007596 tetramer interface [polypeptide binding]; other site 573061007597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061007598 catalytic residue [active] 573061007599 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 573061007600 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 573061007601 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 573061007602 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 573061007603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061007604 catalytic residue [active] 573061007605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061007606 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061007607 Rubredoxin [Energy production and conversion]; Region: COG1773 573061007608 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573061007609 iron binding site [ion binding]; other site 573061007610 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573061007611 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573061007612 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573061007613 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 573061007614 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061007615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061007616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061007617 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 573061007618 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 573061007619 active site 573061007620 dimer interface [polypeptide binding]; other site 573061007621 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 573061007622 YibE/F-like protein; Region: YibE_F; pfam07907 573061007623 Melibiase; Region: Melibiase; pfam02065 573061007624 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 573061007625 Part of AAA domain; Region: AAA_19; pfam13245 573061007626 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573061007627 active site 573061007628 catalytic site [active] 573061007629 substrate binding site [chemical binding]; other site 573061007630 Family description; Region: UvrD_C_2; pfam13538 573061007631 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 573061007632 ArsC family; Region: ArsC; pfam03960 573061007633 catalytic residue [active] 573061007634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061007635 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061007636 Coenzyme A binding pocket [chemical binding]; other site 573061007637 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573061007638 MULE transposase domain; Region: MULE; pfam10551 573061007639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061007640 Coenzyme A binding pocket [chemical binding]; other site 573061007641 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061007642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061007643 non-specific DNA binding site [nucleotide binding]; other site 573061007644 salt bridge; other site 573061007645 sequence-specific DNA binding site [nucleotide binding]; other site 573061007646 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 573061007647 putative dimer interface [polypeptide binding]; other site 573061007648 catalytic triad [active] 573061007649 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061007650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061007651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061007652 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573061007653 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573061007654 active site 573061007655 ATP binding site [chemical binding]; other site 573061007656 substrate binding site [chemical binding]; other site 573061007657 activation loop (A-loop); other site 573061007658 Double zinc ribbon; Region: DZR; pfam12773 573061007659 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 573061007660 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573061007661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061007662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061007663 putative substrate translocation pore; other site 573061007664 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061007665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061007666 Walker A/P-loop; other site 573061007667 ATP binding site [chemical binding]; other site 573061007668 Q-loop/lid; other site 573061007669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061007670 ABC transporter signature motif; other site 573061007671 Walker B; other site 573061007672 ABC transporter; Region: ABC_tran_2; pfam12848 573061007673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061007674 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573061007675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573061007676 homodimer interface [polypeptide binding]; other site 573061007677 substrate-cofactor binding pocket; other site 573061007678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061007679 catalytic residue [active] 573061007680 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 573061007681 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061007682 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573061007683 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573061007684 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061007685 substrate binding site [chemical binding]; other site 573061007686 active site 573061007687 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061007688 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573061007689 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061007690 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573061007691 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 573061007692 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 573061007693 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 573061007694 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573061007695 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061007696 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061007697 substrate binding site [chemical binding]; other site 573061007698 active site 573061007699 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061007700 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007702 active site 573061007703 phosphorylation site [posttranslational modification] 573061007704 intermolecular recognition site; other site 573061007705 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007707 active site 573061007708 phosphorylation site [posttranslational modification] 573061007709 intermolecular recognition site; other site 573061007710 dimerization interface [polypeptide binding]; other site 573061007711 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007713 active site 573061007714 phosphorylation site [posttranslational modification] 573061007715 intermolecular recognition site; other site 573061007716 dimerization interface [polypeptide binding]; other site 573061007717 HDOD domain; Region: HDOD; pfam08668 573061007718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573061007719 PAS domain; Region: PAS_9; pfam13426 573061007720 putative active site [active] 573061007721 heme pocket [chemical binding]; other site 573061007722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573061007723 dimer interface [polypeptide binding]; other site 573061007724 phosphorylation site [posttranslational modification] 573061007725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007726 ATP binding site [chemical binding]; other site 573061007727 Mg2+ binding site [ion binding]; other site 573061007728 G-X-G motif; other site 573061007729 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061007730 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061007731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573061007732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007733 dimer interface [polypeptide binding]; other site 573061007734 putative CheW interface [polypeptide binding]; other site 573061007735 YhhN-like protein; Region: YhhN; cl01505 573061007736 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573061007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007738 active site 573061007739 phosphorylation site [posttranslational modification] 573061007740 intermolecular recognition site; other site 573061007741 dimerization interface [polypeptide binding]; other site 573061007742 CheB methylesterase; Region: CheB_methylest; pfam01339 573061007743 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573061007744 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573061007745 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573061007746 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061007747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061007748 dimerization interface [polypeptide binding]; other site 573061007749 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061007750 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007751 dimer interface [polypeptide binding]; other site 573061007752 putative CheW interface [polypeptide binding]; other site 573061007753 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573061007754 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573061007755 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573061007756 putative binding surface; other site 573061007757 active site 573061007758 P2 response regulator binding domain; Region: P2; pfam07194 573061007759 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573061007760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007761 ATP binding site [chemical binding]; other site 573061007762 Mg2+ binding site [ion binding]; other site 573061007763 G-X-G motif; other site 573061007764 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573061007765 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007767 active site 573061007768 phosphorylation site [posttranslational modification] 573061007769 intermolecular recognition site; other site 573061007770 dimerization interface [polypeptide binding]; other site 573061007771 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061007772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007773 dimer interface [polypeptide binding]; other site 573061007774 putative CheW interface [polypeptide binding]; other site 573061007775 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 573061007776 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573061007777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061007778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061007779 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 573061007780 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573061007781 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573061007782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061007783 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061007784 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061007785 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061007786 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061007787 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061007788 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061007789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061007790 Coenzyme A binding pocket [chemical binding]; other site 573061007791 Uncharacterized conserved protein [Function unknown]; Region: COG3339 573061007792 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061007793 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061007794 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 573061007795 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573061007796 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573061007797 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573061007798 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 573061007799 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573061007800 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 573061007801 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573061007802 active site 573061007803 catalytic triad [active] 573061007804 oxyanion hole [active] 573061007805 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007806 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061007807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061007808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061007809 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573061007810 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 573061007811 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 573061007812 putative sugar binding sites [chemical binding]; other site 573061007813 Q-X-W motif; other site 573061007814 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061007815 substrate binding site [chemical binding]; other site 573061007816 active site 573061007817 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 573061007818 nudix motif; other site 573061007819 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573061007820 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573061007821 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061007822 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 573061007823 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007824 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061007825 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007826 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007828 active site 573061007829 phosphorylation site [posttranslational modification] 573061007830 intermolecular recognition site; other site 573061007831 dimerization interface [polypeptide binding]; other site 573061007832 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061007833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061007834 dimer interface [polypeptide binding]; other site 573061007835 putative CheW interface [polypeptide binding]; other site 573061007836 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573061007837 GAF domain; Region: GAF; cl17456 573061007838 PAS domain; Region: PAS_9; pfam13426 573061007839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061007840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061007841 dimer interface [polypeptide binding]; other site 573061007842 phosphorylation site [posttranslational modification] 573061007843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007844 ATP binding site [chemical binding]; other site 573061007845 Mg2+ binding site [ion binding]; other site 573061007846 G-X-G motif; other site 573061007847 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573061007848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007849 active site 573061007850 phosphorylation site [posttranslational modification] 573061007851 intermolecular recognition site; other site 573061007852 dimerization interface [polypeptide binding]; other site 573061007853 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007855 active site 573061007856 phosphorylation site [posttranslational modification] 573061007857 intermolecular recognition site; other site 573061007858 dimerization interface [polypeptide binding]; other site 573061007859 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573061007860 putative binding surface; other site 573061007861 active site 573061007862 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573061007863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061007864 Zn2+ binding site [ion binding]; other site 573061007865 Mg2+ binding site [ion binding]; other site 573061007866 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 573061007867 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573061007868 putative dimer interface [polypeptide binding]; other site 573061007869 [2Fe-2S] cluster binding site [ion binding]; other site 573061007870 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 573061007871 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 573061007872 P-loop; other site 573061007873 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061007874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573061007875 catalytic loop [active] 573061007876 iron binding site [ion binding]; other site 573061007877 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573061007878 4Fe-4S binding domain; Region: Fer4; pfam00037 573061007879 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 573061007880 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573061007881 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 573061007882 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 573061007883 ACS interaction site; other site 573061007884 CODH interaction site; other site 573061007885 cubane metal cluster (B-cluster) [ion binding]; other site 573061007886 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 573061007887 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573061007888 dimer interface [polypeptide binding]; other site 573061007889 [2Fe-2S] cluster binding site [ion binding]; other site 573061007890 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573061007891 SLBB domain; Region: SLBB; pfam10531 573061007892 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573061007893 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573061007894 4Fe-4S binding domain; Region: Fer4; pfam00037 573061007895 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573061007896 active site 573061007897 catalytic residues [active] 573061007898 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573061007899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061007900 Response regulator receiver domain; Region: Response_reg; pfam00072 573061007901 active site 573061007902 phosphorylation site [posttranslational modification] 573061007903 intermolecular recognition site; other site 573061007904 dimerization interface [polypeptide binding]; other site 573061007905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061007906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061007907 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061007908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061007909 dimerization interface [polypeptide binding]; other site 573061007910 Histidine kinase; Region: His_kinase; pfam06580 573061007911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061007912 ATP binding site [chemical binding]; other site 573061007913 Mg2+ binding site [ion binding]; other site 573061007914 G-X-G motif; other site 573061007915 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061007916 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061007917 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573061007918 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 573061007919 inhibitor binding site; inhibition site 573061007920 active site 573061007921 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 573061007922 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573061007923 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061007924 ligand binding site [chemical binding]; other site 573061007925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061007926 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573061007927 TM-ABC transporter signature motif; other site 573061007928 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573061007929 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573061007930 Walker A/P-loop; other site 573061007931 ATP binding site [chemical binding]; other site 573061007932 Q-loop/lid; other site 573061007933 ABC transporter signature motif; other site 573061007934 Walker B; other site 573061007935 D-loop; other site 573061007936 H-loop/switch region; other site 573061007937 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573061007938 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061007939 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573061007940 sugar binding site [chemical binding]; other site 573061007941 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061007942 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007943 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573061007944 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 573061007945 substrate binding site [chemical binding]; other site 573061007946 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573061007947 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573061007948 substrate binding site [chemical binding]; other site 573061007949 ligand binding site [chemical binding]; other site 573061007950 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061007951 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061007952 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061007953 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 573061007954 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 573061007955 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061007956 putative metal binding site [ion binding]; other site 573061007957 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 573061007958 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061007959 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007960 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061007961 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573061007962 Domain of unknown function DUF21; Region: DUF21; pfam01595 573061007963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573061007964 Transporter associated domain; Region: CorC_HlyC; pfam03471 573061007965 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 573061007966 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573061007967 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 573061007968 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 573061007969 active site 573061007970 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061007971 Kelch domain; Region: Kelch; smart00612 573061007972 Kelch motif; Region: Kelch_1; pfam01344 573061007973 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061007974 Kelch motif; Region: Kelch_1; pfam01344 573061007975 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061007976 Kelch domain; Region: Kelch; smart00612 573061007977 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061007978 Kelch motif; Region: Kelch_1; pfam01344 573061007979 Kelch motif; Region: Kelch_1; pfam01344 573061007980 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 573061007981 Kelch motif; Region: Kelch_1; pfam01344 573061007982 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061007983 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061007984 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573061007985 dimer interface [polypeptide binding]; other site 573061007986 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061007987 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061007988 ligand binding site [chemical binding]; other site 573061007989 calcium binding site [ion binding]; other site 573061007990 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 573061007991 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 573061007992 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 573061007993 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061007994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061007995 Bombinin; Region: Bombinin; pfam05298 573061007996 Nuclease-related domain; Region: NERD; pfam08378 573061007997 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061007998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061007999 Coenzyme A binding pocket [chemical binding]; other site 573061008000 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 573061008001 Condensation domain; Region: Condensation; pfam00668 573061008002 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061008003 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061008004 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 573061008005 acyl-activating enzyme (AAE) consensus motif; other site 573061008006 AMP binding site [chemical binding]; other site 573061008007 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061008008 Condensation domain; Region: Condensation; pfam00668 573061008009 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061008010 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061008011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061008012 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061008013 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061008014 acyl-activating enzyme (AAE) consensus motif; other site 573061008015 AMP binding site [chemical binding]; other site 573061008016 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 573061008017 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573061008018 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573061008019 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573061008020 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573061008021 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573061008022 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573061008023 Ligand Binding Site [chemical binding]; other site 573061008024 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573061008025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573061008026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573061008027 active site 573061008028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 573061008029 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 573061008030 active site 573061008031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061008032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061008033 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573061008034 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573061008035 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 573061008036 active site 573061008037 Probable zinc-binding domain; Region: zf-trcl; pfam13451 573061008038 putative pectinesterase; Region: PLN02432; cl01911 573061008039 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 573061008040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061008041 Helix-turn-helix domain; Region: HTH_18; pfam12833 573061008042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061008043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573061008044 active site 573061008045 ATP binding site [chemical binding]; other site 573061008046 substrate binding site [chemical binding]; other site 573061008047 activation loop (A-loop); other site 573061008048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061008049 binding surface 573061008050 TPR motif; other site 573061008051 SEFIR domain; Region: SEFIR; pfam08357 573061008052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061008053 non-specific DNA binding site [nucleotide binding]; other site 573061008054 salt bridge; other site 573061008055 sequence-specific DNA binding site [nucleotide binding]; other site 573061008056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573061008057 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573061008058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061008059 FeS/SAM binding site; other site 573061008060 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 573061008061 non-specific DNA binding site [nucleotide binding]; other site 573061008062 salt bridge; other site 573061008063 sequence-specific DNA binding site [nucleotide binding]; other site 573061008064 Helix-turn-helix domain; Region: HTH_38; pfam13936 573061008065 Integrase core domain; Region: rve; pfam00665 573061008066 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 573061008067 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573061008068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061008069 S-adenosylmethionine binding site [chemical binding]; other site 573061008070 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 573061008071 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 573061008072 RDD family; Region: RDD; cl00746 573061008073 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573061008074 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573061008075 active site 573061008076 metal binding site [ion binding]; metal-binding site 573061008077 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 573061008078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061008079 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 573061008080 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 573061008081 active site 573061008082 dimer interface [polypeptide binding]; other site 573061008083 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 573061008084 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573061008085 active site 573061008086 FMN binding site [chemical binding]; other site 573061008087 substrate binding site [chemical binding]; other site 573061008088 3Fe-4S cluster binding site [ion binding]; other site 573061008089 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 573061008090 domain interface; other site 573061008091 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061008092 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061008093 HAMP domain; Region: HAMP; pfam00672 573061008094 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061008095 dimer interface [polypeptide binding]; other site 573061008096 putative CheW interface [polypeptide binding]; other site 573061008097 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573061008098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573061008099 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573061008100 pyrophosphatase PpaX; Provisional; Region: PRK13288 573061008101 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 573061008102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061008103 motif II; other site 573061008104 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573061008105 ligand binding site [chemical binding]; other site 573061008106 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 573061008107 RNase_H superfamily; Region: RNase_H_2; pfam13482 573061008108 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 573061008109 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 573061008110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061008111 dimer interface [polypeptide binding]; other site 573061008112 conserved gate region; other site 573061008113 ABC-ATPase subunit interface; other site 573061008114 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 573061008115 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573061008116 Walker A/P-loop; other site 573061008117 ATP binding site [chemical binding]; other site 573061008118 Q-loop/lid; other site 573061008119 ABC transporter signature motif; other site 573061008120 Walker B; other site 573061008121 D-loop; other site 573061008122 H-loop/switch region; other site 573061008123 NIL domain; Region: NIL; pfam09383 573061008124 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 573061008125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061008126 FeS/SAM binding site; other site 573061008127 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 573061008128 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061008129 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061008130 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061008131 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061008132 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 573061008133 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 573061008134 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573061008135 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573061008136 G1 box; other site 573061008137 GTP/Mg2+ binding site [chemical binding]; other site 573061008138 Switch I region; other site 573061008139 G2 box; other site 573061008140 G3 box; other site 573061008141 Switch II region; other site 573061008142 G4 box; other site 573061008143 G5 box; other site 573061008144 Nucleoside recognition; Region: Gate; pfam07670 573061008145 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573061008146 Nucleoside recognition; Region: Gate; pfam07670 573061008147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061008148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061008149 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061008150 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573061008151 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061008152 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573061008153 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573061008154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061008155 DNA-binding site [nucleotide binding]; DNA binding site 573061008156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061008157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061008158 homodimer interface [polypeptide binding]; other site 573061008159 catalytic residue [active] 573061008160 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 573061008161 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 573061008162 active site 573061008163 multimer interface [polypeptide binding]; other site 573061008164 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 573061008165 predicted active site [active] 573061008166 catalytic triad [active] 573061008167 Heme NO binding; Region: HNOB; pfam07700 573061008168 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061008169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061008170 dimer interface [polypeptide binding]; other site 573061008171 putative CheW interface [polypeptide binding]; other site 573061008172 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573061008173 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 573061008174 active site 573061008175 dimer interface [polypeptide binding]; other site 573061008176 metal binding site [ion binding]; metal-binding site 573061008177 stage V sporulation protein K; Region: spore_V_K; TIGR02881 573061008178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061008179 Walker A motif; other site 573061008180 ATP binding site [chemical binding]; other site 573061008181 Walker B motif; other site 573061008182 arginine finger; other site 573061008183 stage V sporulation protein K; Region: spore_V_K; TIGR02881 573061008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061008185 Walker A motif; other site 573061008186 ATP binding site [chemical binding]; other site 573061008187 Walker B motif; other site 573061008188 arginine finger; other site 573061008189 stage V sporulation protein K; Region: spore_V_K; TIGR02881 573061008190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061008191 Walker A motif; other site 573061008192 ATP binding site [chemical binding]; other site 573061008193 Walker B motif; other site 573061008194 arginine finger; other site 573061008195 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573061008196 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061008197 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061008198 HAMP domain; Region: HAMP; pfam00672 573061008199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061008200 dimer interface [polypeptide binding]; other site 573061008201 putative CheW interface [polypeptide binding]; other site 573061008202 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573061008203 Putative esterase; Region: Esterase; pfam00756 573061008204 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 573061008205 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 573061008206 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061008207 NAD binding site [chemical binding]; other site 573061008208 dimer interface [polypeptide binding]; other site 573061008209 substrate binding site [chemical binding]; other site 573061008210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061008211 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061008212 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573061008213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061008214 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573061008215 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061008216 glycerol kinase; Provisional; Region: glpK; PRK00047 573061008217 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 573061008218 N- and C-terminal domain interface [polypeptide binding]; other site 573061008219 active site 573061008220 MgATP binding site [chemical binding]; other site 573061008221 catalytic site [active] 573061008222 metal binding site [ion binding]; metal-binding site 573061008223 glycerol binding site [chemical binding]; other site 573061008224 homotetramer interface [polypeptide binding]; other site 573061008225 homodimer interface [polypeptide binding]; other site 573061008226 FBP binding site [chemical binding]; other site 573061008227 protein IIAGlc interface [polypeptide binding]; other site 573061008228 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 573061008229 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 573061008230 active site 573061008231 catalytic residues [active] 573061008232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061008233 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061008234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061008235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061008236 active site 573061008237 phosphorylation site [posttranslational modification] 573061008238 intermolecular recognition site; other site 573061008239 dimerization interface [polypeptide binding]; other site 573061008240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061008241 DNA binding residues [nucleotide binding] 573061008242 dimerization interface [polypeptide binding]; other site 573061008243 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 573061008244 Collagen binding domain; Region: Collagen_bind; pfam05737 573061008245 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008246 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008247 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008248 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008249 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008250 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008251 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008252 Cna protein B-type domain; Region: Cna_B; pfam05738 573061008253 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 573061008254 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 573061008255 active site 573061008256 catalytic residues [active] 573061008257 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 573061008258 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 573061008259 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 573061008260 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 573061008261 active site 573061008262 catalytic residues [active] 573061008263 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008264 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008265 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008266 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061008268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061008269 dimer interface [polypeptide binding]; other site 573061008270 conserved gate region; other site 573061008271 putative PBP binding loops; other site 573061008272 ABC-ATPase subunit interface; other site 573061008273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061008274 dimer interface [polypeptide binding]; other site 573061008275 conserved gate region; other site 573061008276 putative PBP binding loops; other site 573061008277 ABC-ATPase subunit interface; other site 573061008278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061008279 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061008280 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 573061008281 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 573061008282 active site 573061008283 active site 573061008284 catalytic residues [active] 573061008285 Response regulator receiver domain; Region: Response_reg; pfam00072 573061008286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061008287 active site 573061008288 phosphorylation site [posttranslational modification] 573061008289 intermolecular recognition site; other site 573061008290 dimerization interface [polypeptide binding]; other site 573061008291 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061008292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061008293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061008294 dimerization interface [polypeptide binding]; other site 573061008295 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061008296 Histidine kinase; Region: His_kinase; pfam06580 573061008297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061008298 ATP binding site [chemical binding]; other site 573061008299 Mg2+ binding site [ion binding]; other site 573061008300 G-X-G motif; other site 573061008301 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573061008302 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 573061008303 active site 573061008304 catalytic site [active] 573061008305 putative metal binding site [ion binding]; other site 573061008306 HutD; Region: HutD; pfam05962 573061008307 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573061008308 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573061008309 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573061008310 catalytic residue [active] 573061008311 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573061008312 CoA-binding site [chemical binding]; other site 573061008313 DNA polymerase I; Provisional; Region: PRK05755 573061008314 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573061008315 active site 573061008316 metal binding site 1 [ion binding]; metal-binding site 573061008317 putative 5' ssDNA interaction site; other site 573061008318 metal binding site 3; metal-binding site 573061008319 metal binding site 2 [ion binding]; metal-binding site 573061008320 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573061008321 putative DNA binding site [nucleotide binding]; other site 573061008322 putative metal binding site [ion binding]; other site 573061008323 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 573061008324 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573061008325 active site 573061008326 DNA binding site [nucleotide binding] 573061008327 catalytic site [active] 573061008328 Nuclease-related domain; Region: NERD; pfam08378 573061008329 NAD-dependent deacetylase; Provisional; Region: PRK00481 573061008330 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 573061008331 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 573061008332 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573061008333 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 573061008334 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573061008335 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573061008336 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 573061008337 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061008338 putative active site [active] 573061008339 putative metal binding site [ion binding]; other site 573061008340 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 573061008341 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 573061008342 G1 box; other site 573061008343 GTP/Mg2+ binding site [chemical binding]; other site 573061008344 Switch I region; other site 573061008345 G2 box; other site 573061008346 Switch II region; other site 573061008347 G3 box; other site 573061008348 G4 box; other site 573061008349 G5 box; other site 573061008350 Protein of unknown function (DUF554); Region: DUF554; pfam04474 573061008351 aspartate kinase; Reviewed; Region: PRK09034 573061008352 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573061008353 nucleotide binding site [chemical binding]; other site 573061008354 substrate binding site [chemical binding]; other site 573061008355 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 573061008356 allosteric regulatory residue; other site 573061008357 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 573061008358 endoglucanase; Region: PLN02420 573061008359 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 573061008360 Cellulose binding domain; Region: CBM_3; cl03026 573061008361 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008362 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008363 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573061008364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573061008365 active site 573061008366 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573061008367 homotrimer interaction site [polypeptide binding]; other site 573061008368 putative active site [active] 573061008369 Transcriptional regulator [Transcription]; Region: LytR; COG1316 573061008370 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 573061008371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061008372 Zn2+ binding site [ion binding]; other site 573061008373 Mg2+ binding site [ion binding]; other site 573061008374 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 573061008375 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573061008376 active site 573061008377 (T/H)XGH motif; other site 573061008378 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 573061008379 GTPase CgtA; Reviewed; Region: obgE; PRK12297 573061008380 GTP1/OBG; Region: GTP1_OBG; pfam01018 573061008381 Obg GTPase; Region: Obg; cd01898 573061008382 G1 box; other site 573061008383 GTP/Mg2+ binding site [chemical binding]; other site 573061008384 Switch I region; other site 573061008385 G2 box; other site 573061008386 G3 box; other site 573061008387 Switch II region; other site 573061008388 G4 box; other site 573061008389 G5 box; other site 573061008390 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 573061008391 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573061008392 hypothetical protein; Provisional; Region: PRK14553 573061008393 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573061008394 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 573061008395 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573061008396 homodimer interface [polypeptide binding]; other site 573061008397 oligonucleotide binding site [chemical binding]; other site 573061008398 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 573061008399 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 573061008400 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 573061008401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061008402 FeS/SAM binding site; other site 573061008403 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 573061008404 Peptidase family M50; Region: Peptidase_M50; pfam02163 573061008405 active site 573061008406 putative substrate binding region [chemical binding]; other site 573061008407 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 573061008408 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 573061008409 cell division topological specificity factor MinE; Provisional; Region: PRK13987 573061008410 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 573061008411 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 573061008412 Switch I; other site 573061008413 Switch II; other site 573061008414 septum formation inhibitor; Reviewed; Region: minC; PRK00513 573061008415 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 573061008416 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061008417 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061008418 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573061008419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573061008420 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061008421 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061008422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573061008423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573061008424 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 573061008425 rod shape-determining protein MreC; Provisional; Region: PRK13922 573061008426 rod shape-determining protein MreC; Region: MreC; pfam04085 573061008427 rod shape-determining protein MreB; Provisional; Region: PRK13927 573061008428 MreB and similar proteins; Region: MreB_like; cd10225 573061008429 nucleotide binding site [chemical binding]; other site 573061008430 Mg binding site [ion binding]; other site 573061008431 putative protofilament interaction site [polypeptide binding]; other site 573061008432 RodZ interaction site [polypeptide binding]; other site 573061008433 hypothetical protein; Reviewed; Region: PRK00024 573061008434 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573061008435 MPN+ (JAMM) motif; other site 573061008436 Zinc-binding site [ion binding]; other site 573061008437 Maf-like protein; Reviewed; Region: PRK00078 573061008438 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573061008439 active site 573061008440 dimer interface [polypeptide binding]; other site 573061008441 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 573061008442 Sporulation related domain; Region: SPOR; cl10051 573061008443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 573061008444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061008445 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 573061008446 catalytic motif [active] 573061008447 Zn binding site [ion binding]; other site 573061008448 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 573061008449 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573061008450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061008451 motif II; other site 573061008452 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061008453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061008454 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 573061008455 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573061008456 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573061008457 active site turn [active] 573061008458 phosphorylation site [posttranslational modification] 573061008459 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 573061008460 HPr interaction site; other site 573061008461 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573061008462 active site 573061008463 phosphorylation site [posttranslational modification] 573061008464 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 573061008465 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 573061008466 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 573061008467 active site turn [active] 573061008468 phosphorylation site [posttranslational modification] 573061008469 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 573061008470 HPr interaction site; other site 573061008471 glycerol kinase (GK) interaction site [polypeptide binding]; other site 573061008472 active site 573061008473 phosphorylation site [posttranslational modification] 573061008474 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061008475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061008476 active site 573061008477 phosphorylation site [posttranslational modification] 573061008478 intermolecular recognition site; other site 573061008479 dimerization interface [polypeptide binding]; other site 573061008480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061008481 DNA binding site [nucleotide binding] 573061008482 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573061008483 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573061008484 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573061008485 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 573061008486 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 573061008487 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573061008488 active site 573061008489 HIGH motif; other site 573061008490 KMSK motif region; other site 573061008491 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 573061008492 tRNA binding surface [nucleotide binding]; other site 573061008493 anticodon binding site; other site 573061008494 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573061008495 Sel1-like repeats; Region: SEL1; smart00671 573061008496 Sel1-like repeats; Region: SEL1; smart00671 573061008497 Sel1-like repeats; Region: SEL1; smart00671 573061008498 Sel1-like repeats; Region: SEL1; smart00671 573061008499 Sel1-like repeats; Region: SEL1; smart00671 573061008500 Sel1-like repeats; Region: SEL1; smart00671 573061008501 UV-endonuclease UvdE; Region: UvdE; cl10036 573061008502 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061008503 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061008504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061008505 alpha-galactosidase; Provisional; Region: PRK15076 573061008506 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 573061008507 NAD binding site [chemical binding]; other site 573061008508 sugar binding site [chemical binding]; other site 573061008509 divalent metal binding site [ion binding]; other site 573061008510 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061008511 dimer interface [polypeptide binding]; other site 573061008512 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 573061008513 S1 domain; Region: S1_2; pfam13509 573061008514 S1 domain; Region: S1_2; pfam13509 573061008515 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573061008516 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573061008517 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573061008518 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573061008519 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573061008520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061008521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061008522 Walker A/P-loop; other site 573061008523 ATP binding site [chemical binding]; other site 573061008524 Q-loop/lid; other site 573061008525 ABC transporter signature motif; other site 573061008526 Walker B; other site 573061008527 D-loop; other site 573061008528 H-loop/switch region; other site 573061008529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061008530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061008531 active site 573061008532 phosphorylation site [posttranslational modification] 573061008533 intermolecular recognition site; other site 573061008534 dimerization interface [polypeptide binding]; other site 573061008535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061008536 DNA binding residues [nucleotide binding] 573061008537 dimerization interface [polypeptide binding]; other site 573061008538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573061008539 Histidine kinase; Region: HisKA_3; pfam07730 573061008540 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 573061008541 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573061008542 ligand binding site; other site 573061008543 oligomer interface; other site 573061008544 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573061008545 dimer interface [polypeptide binding]; other site 573061008546 N-terminal domain interface [polypeptide binding]; other site 573061008547 sulfate 1 binding site; other site 573061008548 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 573061008549 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573061008550 ligand binding site; other site 573061008551 oligomer interface; other site 573061008552 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573061008553 dimer interface [polypeptide binding]; other site 573061008554 N-terminal domain interface [polypeptide binding]; other site 573061008555 sulfate 1 binding site; other site 573061008556 putative GTP cyclohydrolase; Provisional; Region: PRK13674 573061008557 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008558 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 573061008559 Melibiase; Region: Melibiase; pfam02065 573061008560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573061008561 substrate binding site [chemical binding]; other site 573061008562 activation loop (A-loop); other site 573061008563 AAA ATPase domain; Region: AAA_16; pfam13191 573061008564 Predicted ATPase [General function prediction only]; Region: COG3899 573061008565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061008566 TPR motif; other site 573061008567 binding surface 573061008568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061008569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061008570 metal binding site [ion binding]; metal-binding site 573061008571 active site 573061008572 I-site; other site 573061008573 GAF domain; Region: GAF_3; pfam13492 573061008574 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573061008575 Catalytic site [active] 573061008576 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 573061008577 active site 573061008578 Kelch motif; Region: Kelch_1; pfam01344 573061008579 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061008580 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061008581 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573061008582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573061008583 putative acyl-acceptor binding pocket; other site 573061008584 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573061008585 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061008586 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 573061008587 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 573061008588 active site 573061008589 substrate binding site [chemical binding]; other site 573061008590 metal binding site [ion binding]; metal-binding site 573061008591 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 573061008592 Domain of unknown function DUF; Region: DUF204; pfam02659 573061008593 DNA polymerase IV; Provisional; Region: PRK14133 573061008594 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573061008595 active site 573061008596 DNA binding site [nucleotide binding] 573061008597 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573061008598 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573061008599 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573061008600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061008601 Walker A/P-loop; other site 573061008602 ATP binding site [chemical binding]; other site 573061008603 Q-loop/lid; other site 573061008604 ABC transporter signature motif; other site 573061008605 Walker B; other site 573061008606 D-loop; other site 573061008607 H-loop/switch region; other site 573061008608 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 573061008609 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 573061008610 Membrane transport protein; Region: Mem_trans; pfam03547 573061008611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061008612 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061008613 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008614 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008615 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061008616 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061008617 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008618 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008619 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008620 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 573061008621 endoglucanase; Region: PLN02420 573061008622 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 573061008623 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008624 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008625 dockerin binding interface; other site 573061008626 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008627 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573061008628 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573061008629 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008630 endoglucanase; Region: PLN02420 573061008631 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 573061008632 Cellulose binding domain; Region: CBM_3; pfam00942 573061008633 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008634 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008635 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 573061008636 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008637 Cellulose binding domain; Region: CBM_3; pfam00942 573061008638 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061008639 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008640 dockerin binding interface; other site 573061008641 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008642 dockerin binding interface; other site 573061008643 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061008644 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008645 dockerin binding interface; other site 573061008646 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008647 dockerin binding interface; other site 573061008648 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008649 dockerin binding interface; other site 573061008650 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008651 dockerin binding interface; other site 573061008652 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008653 dockerin binding interface; other site 573061008654 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061008655 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061008656 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061008657 dockerin binding interface; other site 573061008658 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 573061008659 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 573061008660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061008661 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 573061008662 active site 573061008663 catalytic residues [active] 573061008664 metal binding site [ion binding]; metal-binding site 573061008665 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 573061008666 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 573061008667 metal binding site [ion binding]; metal-binding site 573061008668 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573061008669 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 573061008670 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 573061008671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061008672 FeS/SAM binding site; other site 573061008673 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 573061008674 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 573061008675 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 573061008676 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 573061008677 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573061008678 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573061008679 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 573061008680 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573061008681 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573061008682 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573061008683 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573061008684 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 573061008685 nitrogenase iron protein; Region: nifH; TIGR01287 573061008686 Nucleotide-binding sites [chemical binding]; other site 573061008687 Walker A motif; other site 573061008688 Switch I region of nucleotide binding site; other site 573061008689 Fe4S4 binding sites [ion binding]; other site 573061008690 Switch II region of nucleotide binding site; other site 573061008691 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 573061008692 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573061008693 dimer interface [polypeptide binding]; other site 573061008694 [2Fe-2S] cluster binding site [ion binding]; other site 573061008695 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 573061008696 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 573061008697 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573061008698 dimer interface [polypeptide binding]; other site 573061008699 PYR/PP interface [polypeptide binding]; other site 573061008700 TPP binding site [chemical binding]; other site 573061008701 substrate binding site [chemical binding]; other site 573061008702 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573061008703 Domain of unknown function; Region: EKR; smart00890 573061008704 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573061008705 4Fe-4S binding domain; Region: Fer4; pfam00037 573061008706 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 573061008707 TPP-binding site [chemical binding]; other site 573061008708 dimer interface [polypeptide binding]; other site 573061008709 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573061008710 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 573061008711 putative oligomer interface [polypeptide binding]; other site 573061008712 putative active site [active] 573061008713 metal binding site [ion binding]; metal-binding site 573061008714 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573061008715 homopentamer interface [polypeptide binding]; other site 573061008716 active site 573061008717 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 573061008718 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 573061008719 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 573061008720 dimerization interface [polypeptide binding]; other site 573061008721 active site 573061008722 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 573061008723 Lumazine binding domain; Region: Lum_binding; pfam00677 573061008724 Lumazine binding domain; Region: Lum_binding; pfam00677 573061008725 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 573061008726 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 573061008727 catalytic motif [active] 573061008728 Zn binding site [ion binding]; other site 573061008729 RibD C-terminal domain; Region: RibD_C; cl17279 573061008730 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 573061008731 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573061008732 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061008733 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061008734 putative active site [active] 573061008735 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 573061008736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061008737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061008738 Walker A/P-loop; other site 573061008739 ATP binding site [chemical binding]; other site 573061008740 Q-loop/lid; other site 573061008741 ABC transporter signature motif; other site 573061008742 Walker B; other site 573061008743 D-loop; other site 573061008744 H-loop/switch region; other site 573061008745 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008746 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008747 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008748 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008749 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008750 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008751 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008752 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008753 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008754 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008755 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008756 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008757 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008758 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 573061008759 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008760 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008761 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008762 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008763 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008764 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008765 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008766 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008767 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008768 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008769 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008770 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061008771 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008772 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008773 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008774 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061008775 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573061008776 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573061008777 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 573061008778 putative active site [active] 573061008779 catalytic site [active] 573061008780 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 573061008781 putative active site [active] 573061008782 catalytic site [active] 573061008783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061008784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061008785 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 573061008786 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573061008787 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061008788 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061008789 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573061008790 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 573061008791 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573061008792 ATP binding site [chemical binding]; other site 573061008793 Mg++ binding site [ion binding]; other site 573061008794 motif III; other site 573061008795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061008796 nucleotide binding region [chemical binding]; other site 573061008797 ATP-binding site [chemical binding]; other site 573061008798 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 573061008799 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 573061008800 Sulfatase; Region: Sulfatase; cl17466 573061008801 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 573061008802 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573061008803 polyphosphate kinase; Provisional; Region: PRK05443 573061008804 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 573061008805 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 573061008806 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 573061008807 putative domain interface [polypeptide binding]; other site 573061008808 putative active site [active] 573061008809 catalytic site [active] 573061008810 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 573061008811 putative domain interface [polypeptide binding]; other site 573061008812 putative active site [active] 573061008813 catalytic site [active] 573061008814 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 573061008815 active site 573061008816 dimer interfaces [polypeptide binding]; other site 573061008817 catalytic residues [active] 573061008818 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573061008819 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573061008820 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573061008821 ANTAR domain; Region: ANTAR; pfam03861 573061008822 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573061008823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061008824 dimer interface [polypeptide binding]; other site 573061008825 conserved gate region; other site 573061008826 putative PBP binding loops; other site 573061008827 ABC-ATPase subunit interface; other site 573061008828 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 573061008829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573061008830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061008831 dimer interface [polypeptide binding]; other site 573061008832 conserved gate region; other site 573061008833 putative PBP binding loops; other site 573061008834 ABC-ATPase subunit interface; other site 573061008835 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573061008836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061008837 Walker A/P-loop; other site 573061008838 ATP binding site [chemical binding]; other site 573061008839 Q-loop/lid; other site 573061008840 ABC transporter signature motif; other site 573061008841 Walker B; other site 573061008842 D-loop; other site 573061008843 H-loop/switch region; other site 573061008844 TOBE domain; Region: TOBE_2; pfam08402 573061008845 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 573061008846 putative transporter; Provisional; Region: PRK11660 573061008847 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 573061008848 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573061008849 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 573061008850 PAS domain S-box; Region: sensory_box; TIGR00229 573061008851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061008852 metal binding site [ion binding]; metal-binding site 573061008853 active site 573061008854 I-site; other site 573061008855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573061008856 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573061008857 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 573061008858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061008859 catalytic residue [active] 573061008860 homoserine kinase; Provisional; Region: PRK01212 573061008861 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573061008862 homoserine dehydrogenase; Provisional; Region: PRK06349 573061008863 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573061008864 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573061008865 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 573061008866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061008867 nucleotide binding region [chemical binding]; other site 573061008868 ATP-binding site [chemical binding]; other site 573061008869 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 573061008870 Probable zinc-binding domain; Region: zf-trcl; pfam13451 573061008871 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 573061008872 methionine cluster; other site 573061008873 active site 573061008874 phosphorylation site [posttranslational modification] 573061008875 metal binding site [ion binding]; metal-binding site 573061008876 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 573061008877 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 573061008878 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 573061008879 active site 573061008880 P-loop; other site 573061008881 phosphorylation site [posttranslational modification] 573061008882 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 573061008883 beta-galactosidase; Region: BGL; TIGR03356 573061008884 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573061008885 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573061008886 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573061008887 putative active site [active] 573061008888 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573061008889 EamA-like transporter family; Region: EamA; pfam00892 573061008890 EamA-like transporter family; Region: EamA; pfam00892 573061008891 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573061008892 DNA-binding site [nucleotide binding]; DNA binding site 573061008893 RNA-binding motif; other site 573061008894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061008895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061008896 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061008897 Walker A/P-loop; other site 573061008898 ATP binding site [chemical binding]; other site 573061008899 Q-loop/lid; other site 573061008900 ABC transporter signature motif; other site 573061008901 Walker B; other site 573061008902 D-loop; other site 573061008903 H-loop/switch region; other site 573061008904 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061008905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061008906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061008907 Walker A/P-loop; other site 573061008908 ATP binding site [chemical binding]; other site 573061008909 Q-loop/lid; other site 573061008910 ABC transporter signature motif; other site 573061008911 Walker B; other site 573061008912 D-loop; other site 573061008913 H-loop/switch region; other site 573061008914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573061008915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061008916 putative DNA binding site [nucleotide binding]; other site 573061008917 putative Zn2+ binding site [ion binding]; other site 573061008918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573061008919 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 573061008920 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573061008921 ligand binding site; other site 573061008922 oligomer interface; other site 573061008923 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573061008924 dimer interface [polypeptide binding]; other site 573061008925 N-terminal domain interface [polypeptide binding]; other site 573061008926 sulfate 1 binding site; other site 573061008927 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 573061008928 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573061008929 ligand binding site; other site 573061008930 oligomer interface; other site 573061008931 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573061008932 dimer interface [polypeptide binding]; other site 573061008933 N-terminal domain interface [polypeptide binding]; other site 573061008934 sulfate 1 binding site; other site 573061008935 glycogen synthase; Provisional; Region: glgA; PRK00654 573061008936 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 573061008937 ADP-binding pocket [chemical binding]; other site 573061008938 homodimer interface [polypeptide binding]; other site 573061008939 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061008940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061008941 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 573061008942 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 573061008943 putative ATP binding site [chemical binding]; other site 573061008944 putative substrate interface [chemical binding]; other site 573061008945 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 573061008946 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 573061008947 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 573061008948 substrate binding pocket [chemical binding]; other site 573061008949 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 573061008950 B12 binding site [chemical binding]; other site 573061008951 cobalt ligand [ion binding]; other site 573061008952 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 573061008953 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 573061008954 putative catalytic site [active] 573061008955 putative metal binding site [ion binding]; other site 573061008956 putative phosphate binding site [ion binding]; other site 573061008957 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 573061008958 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 573061008959 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008960 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061008961 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 573061008962 phosphofructokinase; Region: PFK_mixed; TIGR02483 573061008963 active site 573061008964 ADP/pyrophosphate binding site [chemical binding]; other site 573061008965 dimerization interface [polypeptide binding]; other site 573061008966 allosteric effector site; other site 573061008967 fructose-1,6-bisphosphate binding site; other site 573061008968 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 573061008969 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 573061008970 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 573061008971 putative active site [active] 573061008972 putative metal binding site [ion binding]; other site 573061008973 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 573061008974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061008975 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 573061008976 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 573061008977 catalytic triad [active] 573061008978 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061008979 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 573061008980 NodB motif; other site 573061008981 active site 573061008982 catalytic site [active] 573061008983 Zn binding site [ion binding]; other site 573061008984 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573061008985 Clp amino terminal domain; Region: Clp_N; pfam02861 573061008986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061008987 Walker A motif; other site 573061008988 ATP binding site [chemical binding]; other site 573061008989 Walker B motif; other site 573061008990 arginine finger; other site 573061008991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061008992 Walker A motif; other site 573061008993 ATP binding site [chemical binding]; other site 573061008994 Walker B motif; other site 573061008995 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573061008996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061008997 non-specific DNA binding site [nucleotide binding]; other site 573061008998 salt bridge; other site 573061008999 sequence-specific DNA binding site [nucleotide binding]; other site 573061009000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009001 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061009002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061009003 non-specific DNA binding site [nucleotide binding]; other site 573061009004 salt bridge; other site 573061009005 sequence-specific DNA binding site [nucleotide binding]; other site 573061009006 YtxH-like protein; Region: YtxH; cl02079 573061009007 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 573061009008 RNA/DNA hybrid binding site [nucleotide binding]; other site 573061009009 active site 573061009010 Uncharacterized conserved protein [Function unknown]; Region: COG3339 573061009011 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 573061009012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061009013 Walker A motif; other site 573061009014 ATP binding site [chemical binding]; other site 573061009015 Walker B motif; other site 573061009016 arginine finger; other site 573061009017 Peptidase family M41; Region: Peptidase_M41; pfam01434 573061009018 oligoendopeptidase F; Region: pepF; TIGR00181 573061009019 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 573061009020 active site 573061009021 Zn binding site [ion binding]; other site 573061009022 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573061009023 metal binding site 2 [ion binding]; metal-binding site 573061009024 putative DNA binding helix; other site 573061009025 metal binding site 1 [ion binding]; metal-binding site 573061009026 dimer interface [polypeptide binding]; other site 573061009027 structural Zn2+ binding site [ion binding]; other site 573061009028 Predicted membrane protein [Function unknown]; Region: COG1971 573061009029 Domain of unknown function DUF; Region: DUF204; pfam02659 573061009030 Domain of unknown function DUF; Region: DUF204; pfam02659 573061009031 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573061009032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573061009033 dimer interface [polypeptide binding]; other site 573061009034 ssDNA binding site [nucleotide binding]; other site 573061009035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061009036 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061009037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061009038 S-adenosylmethionine binding site [chemical binding]; other site 573061009039 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 573061009040 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 573061009041 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 573061009042 Beta-lactamase; Region: Beta-lactamase; pfam00144 573061009043 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573061009044 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573061009045 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061009046 Walker A/P-loop; other site 573061009047 ATP binding site [chemical binding]; other site 573061009048 Q-loop/lid; other site 573061009049 ABC transporter signature motif; other site 573061009050 Walker B; other site 573061009051 D-loop; other site 573061009052 H-loop/switch region; other site 573061009053 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061009054 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061009055 dimer interface [polypeptide binding]; other site 573061009056 putative CheW interface [polypeptide binding]; other site 573061009057 calcium/proton exchanger (cax); Region: cax; TIGR00378 573061009058 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573061009059 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573061009060 HNH endonuclease; Region: HNH_3; pfam13392 573061009061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061009062 HAMP domain; Region: HAMP; pfam00672 573061009063 dimerization interface [polypeptide binding]; other site 573061009064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061009065 dimer interface [polypeptide binding]; other site 573061009066 phosphorylation site [posttranslational modification] 573061009067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061009068 ATP binding site [chemical binding]; other site 573061009069 Mg2+ binding site [ion binding]; other site 573061009070 G-X-G motif; other site 573061009071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061009072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061009073 active site 573061009074 phosphorylation site [posttranslational modification] 573061009075 intermolecular recognition site; other site 573061009076 dimerization interface [polypeptide binding]; other site 573061009077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061009078 DNA binding site [nucleotide binding] 573061009079 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061009080 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061009081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061009082 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061009083 Walker A/P-loop; other site 573061009084 ATP binding site [chemical binding]; other site 573061009085 Q-loop/lid; other site 573061009086 ABC transporter signature motif; other site 573061009087 Walker B; other site 573061009088 D-loop; other site 573061009089 H-loop/switch region; other site 573061009090 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061009091 FtsX-like permease family; Region: FtsX; pfam02687 573061009092 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 573061009093 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573061009094 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573061009095 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 573061009096 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 573061009097 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573061009098 active site 573061009099 dimer interface [polypeptide binding]; other site 573061009100 Melibiase; Region: Melibiase; pfam02065 573061009101 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061009102 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573061009103 active site 573061009104 metal binding site [ion binding]; metal-binding site 573061009105 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061009106 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573061009107 substrate binding pocket [chemical binding]; other site 573061009108 membrane-bound complex binding site; other site 573061009109 hinge residues; other site 573061009110 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 573061009111 Int/Topo IB signature motif; other site 573061009112 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 573061009113 Replication initiation factor; Region: Rep_trans; pfam02486 573061009114 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573061009115 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573061009116 GMP synthase; Reviewed; Region: guaA; PRK00074 573061009117 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573061009118 AMP/PPi binding site [chemical binding]; other site 573061009119 candidate oxyanion hole; other site 573061009120 catalytic triad [active] 573061009121 potential glutamine specificity residues [chemical binding]; other site 573061009122 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573061009123 ATP Binding subdomain [chemical binding]; other site 573061009124 Ligand Binding sites [chemical binding]; other site 573061009125 Dimerization subdomain; other site 573061009126 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573061009127 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573061009128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573061009129 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573061009130 active site 573061009131 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 573061009132 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 573061009133 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573061009134 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573061009135 ring oligomerisation interface [polypeptide binding]; other site 573061009136 ATP/Mg binding site [chemical binding]; other site 573061009137 stacking interactions; other site 573061009138 hinge regions; other site 573061009139 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573061009140 oligomerisation interface [polypeptide binding]; other site 573061009141 mobile loop; other site 573061009142 roof hairpin; other site 573061009143 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 573061009144 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573061009145 putative active site [active] 573061009146 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573061009147 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573061009148 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573061009149 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 573061009150 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 573061009151 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573061009152 minor groove reading motif; other site 573061009153 helix-hairpin-helix signature motif; other site 573061009154 substrate binding pocket [chemical binding]; other site 573061009155 active site 573061009156 putative oxidoreductase; Provisional; Region: PRK12831 573061009157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573061009158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061009159 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 573061009160 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 573061009161 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573061009162 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573061009163 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573061009164 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 573061009165 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573061009166 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573061009167 Ligand binding site [chemical binding]; other site 573061009168 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573061009169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573061009170 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 573061009171 FAD binding site [chemical binding]; other site 573061009172 homotetramer interface [polypeptide binding]; other site 573061009173 substrate binding pocket [chemical binding]; other site 573061009174 catalytic base [active] 573061009175 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 573061009176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573061009177 substrate binding site [chemical binding]; other site 573061009178 oxyanion hole (OAH) forming residues; other site 573061009179 trimer interface [polypeptide binding]; other site 573061009180 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 573061009181 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 573061009182 CoA binding domain; Region: CoA_binding; pfam02629 573061009183 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061009184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061009185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061009186 ABC transporter; Region: ABC_tran_2; pfam12848 573061009187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061009188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009189 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061009190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573061009192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573061009193 metal binding site [ion binding]; metal-binding site 573061009194 active site 573061009195 I-site; other site 573061009196 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061009197 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061009198 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 573061009199 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 573061009200 Walker A/P-loop; other site 573061009201 ATP binding site [chemical binding]; other site 573061009202 Q-loop/lid; other site 573061009203 ABC transporter signature motif; other site 573061009204 Walker B; other site 573061009205 D-loop; other site 573061009206 H-loop/switch region; other site 573061009207 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 573061009208 Right handed beta helix region; Region: Beta_helix; pfam13229 573061009209 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009210 Cytokine receptor motif; other site 573061009211 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009212 Cytokine receptor motif; other site 573061009213 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009214 Cytokine receptor motif; other site 573061009215 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009216 Cytokine receptor motif; other site 573061009217 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009218 Cytokine receptor motif; other site 573061009219 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573061009220 Cytokine receptor motif; other site 573061009221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061009222 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061009223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061009224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009225 Coenzyme A binding pocket [chemical binding]; other site 573061009226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009227 Coenzyme A binding pocket [chemical binding]; other site 573061009228 hypothetical protein; Provisional; Region: PRK06761 573061009229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061009230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061009231 putative substrate translocation pore; other site 573061009232 dipeptidase PepV; Reviewed; Region: PRK07318 573061009233 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 573061009234 active site 573061009235 metal binding site [ion binding]; metal-binding site 573061009236 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 573061009237 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573061009238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061009239 S-adenosylmethionine binding site [chemical binding]; other site 573061009240 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 573061009241 UGMP family protein; Validated; Region: PRK09604 573061009242 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 573061009243 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 573061009244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573061009245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061009246 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573061009247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061009248 RNA binding surface [nucleotide binding]; other site 573061009249 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 573061009250 probable active site [active] 573061009251 Pleckstrin homology-like domain; Region: PH-like; cl17171 573061009252 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573061009253 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573061009254 hinge; other site 573061009255 active site 573061009256 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573061009257 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 573061009258 nudix motif; other site 573061009259 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061009260 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061009261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061009262 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061009263 S-adenosylmethionine binding site [chemical binding]; other site 573061009264 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 573061009265 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573061009266 ligand binding site [chemical binding]; other site 573061009267 flexible hinge region; other site 573061009268 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573061009269 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573061009270 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573061009271 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573061009272 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573061009273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061009274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061009275 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061009276 FMN binding site [chemical binding]; other site 573061009277 dimer interface [polypeptide binding]; other site 573061009278 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573061009279 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 573061009280 active site 573061009281 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573061009282 active site 573061009283 8-oxo-dGMP binding site [chemical binding]; other site 573061009284 nudix motif; other site 573061009285 metal binding site [ion binding]; metal-binding site 573061009286 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 573061009287 PLD-like domain; Region: PLDc_2; pfam13091 573061009288 putative homodimer interface [polypeptide binding]; other site 573061009289 putative active site [active] 573061009290 catalytic site [active] 573061009291 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 573061009292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061009293 ATP binding site [chemical binding]; other site 573061009294 putative Mg++ binding site [ion binding]; other site 573061009295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061009296 nucleotide binding region [chemical binding]; other site 573061009297 ATP-binding site [chemical binding]; other site 573061009298 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 573061009299 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061009300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009301 Coenzyme A binding pocket [chemical binding]; other site 573061009302 YoaP-like; Region: YoaP; pfam14268 573061009303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061009304 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573061009305 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061009306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061009307 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573061009308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061009309 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 573061009310 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573061009311 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573061009312 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573061009313 NAD binding site [chemical binding]; other site 573061009314 substrate binding site [chemical binding]; other site 573061009315 homodimer interface [polypeptide binding]; other site 573061009316 active site 573061009317 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573061009318 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573061009319 substrate binding site; other site 573061009320 tetramer interface; other site 573061009321 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573061009322 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573061009323 Probable Catalytic site; other site 573061009324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573061009325 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573061009326 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573061009327 intersubunit interface [polypeptide binding]; other site 573061009328 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 573061009329 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573061009330 Glycoprotease family; Region: Peptidase_M22; pfam00814 573061009331 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 573061009332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009333 Coenzyme A binding pocket [chemical binding]; other site 573061009334 Predicted membrane protein [Function unknown]; Region: COG3601 573061009335 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 573061009336 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 573061009337 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 573061009338 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 573061009339 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 573061009340 RNA binding site [nucleotide binding]; other site 573061009341 peptide chain release factor 2; Provisional; Region: PRK05589 573061009342 PCRF domain; Region: PCRF; pfam03462 573061009343 RF-1 domain; Region: RF-1; pfam00472 573061009344 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 573061009345 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061009346 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573061009347 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573061009348 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573061009349 SEC-C motif; Region: SEC-C; pfam02810 573061009350 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573061009351 30S subunit binding site; other site 573061009352 comF family protein; Region: comF; TIGR00201 573061009353 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061009354 active site 573061009355 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 573061009356 AAA domain; Region: AAA_30; pfam13604 573061009357 Family description; Region: UvrD_C_2; pfam13538 573061009358 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573061009359 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573061009360 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573061009361 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573061009362 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 573061009363 rod shape-determining protein Mbl; Provisional; Region: PRK13928 573061009364 MreB and similar proteins; Region: MreB_like; cd10225 573061009365 nucleotide binding site [chemical binding]; other site 573061009366 Mg binding site [ion binding]; other site 573061009367 putative protofilament interaction site [polypeptide binding]; other site 573061009368 RodZ interaction site [polypeptide binding]; other site 573061009369 Stage III sporulation protein D; Region: SpoIIID; pfam12116 573061009370 Peptidase family M23; Region: Peptidase_M23; pfam01551 573061009371 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573061009372 stage II sporulation protein D; Region: spore_II_D; TIGR02870 573061009373 Stage II sporulation protein; Region: SpoIID; pfam08486 573061009374 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573061009375 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573061009376 hinge; other site 573061009377 active site 573061009378 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 573061009379 gamma subunit interface [polypeptide binding]; other site 573061009380 epsilon subunit interface [polypeptide binding]; other site 573061009381 LBP interface [polypeptide binding]; other site 573061009382 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573061009383 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573061009384 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573061009385 alpha subunit interaction interface [polypeptide binding]; other site 573061009386 Walker A motif; other site 573061009387 ATP binding site [chemical binding]; other site 573061009388 Walker B motif; other site 573061009389 inhibitor binding site; inhibition site 573061009390 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573061009391 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573061009392 core domain interface [polypeptide binding]; other site 573061009393 delta subunit interface [polypeptide binding]; other site 573061009394 epsilon subunit interface [polypeptide binding]; other site 573061009395 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573061009396 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573061009397 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573061009398 beta subunit interaction interface [polypeptide binding]; other site 573061009399 Walker A motif; other site 573061009400 ATP binding site [chemical binding]; other site 573061009401 Walker B motif; other site 573061009402 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573061009403 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 573061009404 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 573061009405 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 573061009406 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573061009407 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 573061009408 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573061009409 putative acyltransferase; Provisional; Region: PRK05790 573061009410 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573061009411 dimer interface [polypeptide binding]; other site 573061009412 active site 573061009413 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 573061009414 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573061009415 active site 573061009416 homodimer interface [polypeptide binding]; other site 573061009417 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 573061009418 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 573061009419 Mg++ binding site [ion binding]; other site 573061009420 putative catalytic motif [active] 573061009421 substrate binding site [chemical binding]; other site 573061009422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061009423 active site 573061009424 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 573061009425 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573061009426 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573061009427 active site 573061009428 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 573061009429 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 573061009430 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 573061009431 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573061009432 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573061009433 RF-1 domain; Region: RF-1; pfam00472 573061009434 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573061009435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061009436 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 573061009437 thymidine kinase; Provisional; Region: PRK04296 573061009438 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573061009439 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 573061009440 transcription termination factor Rho; Provisional; Region: PRK12608 573061009441 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573061009442 RNA binding site [nucleotide binding]; other site 573061009443 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573061009444 Walker A motif; other site 573061009445 ATP binding site [chemical binding]; other site 573061009446 Walker B motif; other site 573061009447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573061009448 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573061009449 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061009450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009451 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061009452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009453 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 573061009454 Switch II region; other site 573061009455 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 573061009456 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573061009457 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573061009458 ligand binding site [chemical binding]; other site 573061009459 flagellar motor protein MotA; Validated; Region: PRK08124 573061009460 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573061009461 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061009462 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 573061009463 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 573061009464 Clostridial hydrophobic W; Region: ChW; pfam07538 573061009465 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 573061009466 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 573061009467 Clostridial hydrophobic W; Region: ChW; pfam07538 573061009468 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 573061009469 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 573061009470 NodB motif; other site 573061009471 active site 573061009472 catalytic site [active] 573061009473 Cd binding site [ion binding]; other site 573061009474 CTP synthetase; Validated; Region: pyrG; PRK05380 573061009475 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573061009476 Catalytic site [active] 573061009477 active site 573061009478 UTP binding site [chemical binding]; other site 573061009479 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573061009480 active site 573061009481 putative oxyanion hole; other site 573061009482 catalytic triad [active] 573061009483 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 573061009484 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 573061009485 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573061009486 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061009487 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 573061009488 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 573061009489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061009490 CHASE3 domain; Region: CHASE3; cl05000 573061009491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061009492 dimerization interface [polypeptide binding]; other site 573061009493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061009494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061009495 dimer interface [polypeptide binding]; other site 573061009496 putative CheW interface [polypeptide binding]; other site 573061009497 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061009498 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061009499 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 573061009500 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 573061009501 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 573061009502 Spore germination protein; Region: Spore_permease; cl17796 573061009503 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 573061009504 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 573061009505 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573061009506 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 573061009507 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 573061009508 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 573061009509 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 573061009510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573061009511 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 573061009512 Cache domain; Region: Cache_1; pfam02743 573061009513 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061009514 HAMP domain; Region: HAMP; pfam00672 573061009515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061009516 dimer interface [polypeptide binding]; other site 573061009517 putative CheW interface [polypeptide binding]; other site 573061009518 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061009519 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061009520 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061009521 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061009522 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061009523 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061009524 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 573061009525 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061009526 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061009527 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061009528 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061009529 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 573061009530 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573061009531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061009532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061009533 DNA binding residues [nucleotide binding] 573061009534 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573061009535 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 573061009536 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 573061009537 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573061009538 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 573061009539 putative active site [active] 573061009540 catalytic triad [active] 573061009541 putative dimer interface [polypeptide binding]; other site 573061009542 Condensation domain; Region: Condensation; pfam00668 573061009543 Condensation domain; Region: Condensation; pfam00668 573061009544 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 573061009545 Cupin domain; Region: Cupin_2; pfam07883 573061009546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061009548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009549 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061009550 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061009551 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061009552 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061009553 Pectic acid lyase; Region: Pec_lyase; pfam09492 573061009554 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 573061009555 Pectinesterase; Region: Pectinesterase; pfam01095 573061009556 putative pectinesterase; Region: PLN02432; cl01911 573061009557 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573061009558 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573061009559 dimer interface [polypeptide binding]; other site 573061009560 active site 573061009561 catalytic residue [active] 573061009562 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573061009563 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573061009564 dimer interface [polypeptide binding]; other site 573061009565 anticodon binding site; other site 573061009566 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573061009567 homodimer interface [polypeptide binding]; other site 573061009568 motif 1; other site 573061009569 active site 573061009570 motif 2; other site 573061009571 GAD domain; Region: GAD; pfam02938 573061009572 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573061009573 active site 573061009574 motif 3; other site 573061009575 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061009576 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061009577 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061009578 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 573061009579 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061009580 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 573061009581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061009582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061009583 Walker A/P-loop; other site 573061009584 ATP binding site [chemical binding]; other site 573061009585 Q-loop/lid; other site 573061009586 ABC transporter signature motif; other site 573061009587 Walker B; other site 573061009588 D-loop; other site 573061009589 H-loop/switch region; other site 573061009590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061009591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061009592 Walker A/P-loop; other site 573061009593 ATP binding site [chemical binding]; other site 573061009594 Q-loop/lid; other site 573061009595 ABC transporter signature motif; other site 573061009596 Walker B; other site 573061009597 D-loop; other site 573061009598 H-loop/switch region; other site 573061009599 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 573061009600 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573061009601 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 573061009602 active site 573061009603 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573061009604 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 573061009605 acyl-activating enzyme (AAE) consensus motif; other site 573061009606 active site 573061009607 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573061009608 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061009609 acyl-activating enzyme (AAE) consensus motif; other site 573061009610 AMP binding site [chemical binding]; other site 573061009611 active site 573061009612 CoA binding site [chemical binding]; other site 573061009613 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573061009614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573061009615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573061009616 catalytic residue [active] 573061009617 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 573061009618 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061009619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573061009620 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573061009621 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573061009622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061009623 FeS/SAM binding site; other site 573061009624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061009625 Condensation domain; Region: Condensation; pfam00668 573061009626 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061009627 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061009628 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061009629 acyl-activating enzyme (AAE) consensus motif; other site 573061009630 AMP binding site [chemical binding]; other site 573061009631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061009632 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 573061009633 Phosphopantetheine attachment site; Region: PP-binding; cl09936 573061009634 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 573061009635 acyl carrier protein; Provisional; Region: PRK07081 573061009636 H+ Antiporter protein; Region: 2A0121; TIGR00900 573061009637 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 573061009638 active site 573061009639 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 573061009640 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573061009641 active site 573061009642 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 573061009643 homodimer interface [polypeptide binding]; other site 573061009644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573061009645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573061009646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061009647 FeS/SAM binding site; other site 573061009648 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 573061009649 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573061009650 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573061009651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061009652 H+ Antiporter protein; Region: 2A0121; TIGR00900 573061009653 putative substrate translocation pore; other site 573061009654 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573061009655 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 573061009656 Uncharacterized conserved protein [Function unknown]; Region: COG4198 573061009657 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573061009658 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 573061009659 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 573061009660 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 573061009661 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573061009662 dimer interface [polypeptide binding]; other site 573061009663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061009664 catalytic residue [active] 573061009665 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061009666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 573061009667 non-specific DNA binding site [nucleotide binding]; other site 573061009668 salt bridge; other site 573061009669 sequence-specific DNA binding site [nucleotide binding]; other site 573061009670 Phosphotransferase enzyme family; Region: APH; pfam01636 573061009671 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061009672 active site 573061009673 ATP binding site [chemical binding]; other site 573061009674 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061009675 substrate binding site [chemical binding]; other site 573061009676 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061009677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061009678 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061009679 Walker A/P-loop; other site 573061009680 ATP binding site [chemical binding]; other site 573061009681 Q-loop/lid; other site 573061009682 ABC transporter signature motif; other site 573061009683 Walker B; other site 573061009684 D-loop; other site 573061009685 H-loop/switch region; other site 573061009686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061009687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061009688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061009689 Walker A/P-loop; other site 573061009690 ATP binding site [chemical binding]; other site 573061009691 Q-loop/lid; other site 573061009692 ABC transporter signature motif; other site 573061009693 Walker B; other site 573061009694 D-loop; other site 573061009695 H-loop/switch region; other site 573061009696 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573061009697 MarR family; Region: MarR_2; pfam12802 573061009698 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573061009699 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 573061009700 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573061009701 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573061009702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061009703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061009704 active site 573061009705 phosphorylation site [posttranslational modification] 573061009706 intermolecular recognition site; other site 573061009707 dimerization interface [polypeptide binding]; other site 573061009708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061009709 DNA binding site [nucleotide binding] 573061009710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061009711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061009712 dimerization interface [polypeptide binding]; other site 573061009713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061009714 dimer interface [polypeptide binding]; other site 573061009715 phosphorylation site [posttranslational modification] 573061009716 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573061009717 ATP binding site [chemical binding]; other site 573061009718 Mg2+ binding site [ion binding]; other site 573061009719 G-X-G motif; other site 573061009720 YabG peptidase U57; Region: Peptidase_U57; pfam05582 573061009721 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 573061009722 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061009723 active site 573061009724 ATP binding site [chemical binding]; other site 573061009725 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061009726 substrate binding site [chemical binding]; other site 573061009727 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573061009728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061009729 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 573061009730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061009731 substrate binding site [chemical binding]; other site 573061009732 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 573061009733 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 573061009734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061009735 substrate binding site [chemical binding]; other site 573061009736 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573061009737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061009738 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573061009739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061009740 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 573061009741 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 573061009742 putative active site [active] 573061009743 PhoH-like protein; Region: PhoH; pfam02562 573061009744 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061009745 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061009746 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061009747 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061009748 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061009749 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061009750 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061009751 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061009752 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061009753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573061009754 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 573061009755 RNA/DNA hybrid binding site [nucleotide binding]; other site 573061009756 active site 573061009757 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 573061009758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061009759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061009760 homodimer interface [polypeptide binding]; other site 573061009761 catalytic residue [active] 573061009762 multifunctional aminopeptidase A; Provisional; Region: PRK00913 573061009763 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573061009764 interface (dimer of trimers) [polypeptide binding]; other site 573061009765 Substrate-binding/catalytic site; other site 573061009766 Zn-binding sites [ion binding]; other site 573061009767 M6 family metalloprotease domain; Region: M6dom_TIGR03296 573061009768 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573061009769 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 573061009770 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 573061009771 putative active site [active] 573061009772 putative triphosphate binding site [ion binding]; other site 573061009773 dimer interface [polypeptide binding]; other site 573061009774 TPR repeat; Region: TPR_11; pfam13414 573061009775 Tetratricopeptide repeat; Region: TPR_2; pfam07719 573061009776 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573061009777 HSP70 interaction site [polypeptide binding]; other site 573061009778 TPR repeat; Region: TPR_11; pfam13414 573061009779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573061009780 TPR motif; other site 573061009781 binding surface 573061009782 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 573061009783 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 573061009784 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 573061009785 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061009786 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 573061009787 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573061009788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009789 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061009790 Coenzyme A binding pocket [chemical binding]; other site 573061009791 Domain of unknown function (DUF377); Region: DUF377; pfam04041 573061009792 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573061009793 active site 573061009794 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573061009795 active site 573061009796 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 573061009797 putative active cleft [active] 573061009798 dimerization interface [polypeptide binding]; other site 573061009799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061009800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061009801 dimer interface [polypeptide binding]; other site 573061009802 conserved gate region; other site 573061009803 putative PBP binding loops; other site 573061009804 ABC-ATPase subunit interface; other site 573061009805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061009806 dimer interface [polypeptide binding]; other site 573061009807 conserved gate region; other site 573061009808 putative PBP binding loops; other site 573061009809 ABC-ATPase subunit interface; other site 573061009810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061009811 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061009812 Response regulator receiver domain; Region: Response_reg; pfam00072 573061009813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061009814 active site 573061009815 phosphorylation site [posttranslational modification] 573061009816 intermolecular recognition site; other site 573061009817 dimerization interface [polypeptide binding]; other site 573061009818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009819 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061009820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061009821 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061009822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061009823 dimerization interface [polypeptide binding]; other site 573061009824 Histidine kinase; Region: His_kinase; pfam06580 573061009825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061009826 ATP binding site [chemical binding]; other site 573061009827 Mg2+ binding site [ion binding]; other site 573061009828 G-X-G motif; other site 573061009829 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 573061009830 active site 573061009831 catalytic triad [active] 573061009832 oxyanion hole [active] 573061009833 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 573061009834 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061009835 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573061009836 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573061009837 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061009838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061009839 DNA binding site [nucleotide binding] 573061009840 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061009841 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573061009842 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573061009843 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573061009844 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 573061009845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061009846 Walker A motif; other site 573061009847 ATP binding site [chemical binding]; other site 573061009848 Walker B motif; other site 573061009849 arginine finger; other site 573061009850 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 573061009851 putative active site [active] 573061009852 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573061009853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061009854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061009855 non-specific DNA binding site [nucleotide binding]; other site 573061009856 salt bridge; other site 573061009857 sequence-specific DNA binding site [nucleotide binding]; other site 573061009858 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 573061009859 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573061009860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061009861 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061009862 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061009863 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 573061009864 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 573061009865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 573061009866 ligand binding site [chemical binding]; other site 573061009867 YhhN-like protein; Region: YhhN; pfam07947 573061009868 Helix-turn-helix domain; Region: HTH_36; pfam13730 573061009869 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 573061009870 recombinase A; Provisional; Region: recA; PRK09354 573061009871 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573061009872 hexamer interface [polypeptide binding]; other site 573061009873 Walker A motif; other site 573061009874 ATP binding site [chemical binding]; other site 573061009875 Walker B motif; other site 573061009876 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 573061009877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061009878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061009879 putative substrate translocation pore; other site 573061009880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061009881 NB-ARC domain; Region: NB-ARC; pfam00931 573061009882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061009884 binding surface 573061009885 TPR motif; other site 573061009886 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061009890 binding surface 573061009891 TPR motif; other site 573061009892 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061009893 SIR2-like domain; Region: SIR2_2; pfam13289 573061009894 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 573061009895 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061009896 active site 573061009897 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 573061009898 Protein of unknown function (DUF998); Region: DUF998; pfam06197 573061009899 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 573061009900 dimer interface [polypeptide binding]; other site 573061009901 FMN binding site [chemical binding]; other site 573061009902 Pirin-related protein [General function prediction only]; Region: COG1741 573061009903 Pirin; Region: Pirin; pfam02678 573061009904 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061009905 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061009906 Cellulose binding domain; Region: CBM_2; pfam00553 573061009907 Predicted transcriptional regulators [Transcription]; Region: COG1733 573061009908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061009909 dimerization interface [polypeptide binding]; other site 573061009910 putative DNA binding site [nucleotide binding]; other site 573061009911 putative Zn2+ binding site [ion binding]; other site 573061009912 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 573061009913 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 573061009914 Pleckstrin homology-like domain; Region: PH-like; cl17171 573061009915 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061009916 putative active site [active] 573061009917 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 573061009918 active site 573061009919 catalytic site [active] 573061009920 major head protein; Region: PHA00144 573061009921 major head protein; Region: PHA00144 573061009922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573061009923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061009924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061009925 DNA binding residues [nucleotide binding] 573061009926 dimerization interface [polypeptide binding]; other site 573061009927 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 573061009928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573061009929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061009930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009931 Coenzyme A binding pocket [chemical binding]; other site 573061009932 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 573061009933 Part of AAA domain; Region: AAA_19; pfam13245 573061009934 Family description; Region: UvrD_C_2; pfam13538 573061009935 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 573061009936 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573061009937 active site 573061009938 HIGH motif; other site 573061009939 KMSKS motif; other site 573061009940 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573061009941 tRNA binding surface [nucleotide binding]; other site 573061009942 anticodon binding site; other site 573061009943 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 573061009944 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 573061009945 putative active site [active] 573061009946 putative Zn binding site [ion binding]; other site 573061009947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573061009948 Walker A motif; other site 573061009949 ATP binding site [chemical binding]; other site 573061009950 Walker B motif; other site 573061009951 arginine finger; other site 573061009952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061009953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573061009954 DNA binding residues [nucleotide binding] 573061009955 dimerization interface [polypeptide binding]; other site 573061009956 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 573061009957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 573061009958 putative active site [active] 573061009959 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 573061009960 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 573061009961 catalytic triad [active] 573061009962 Helix-turn-helix domain; Region: HTH_18; pfam12833 573061009963 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061009964 active site 573061009965 substrate binding site [chemical binding]; other site 573061009966 ATP binding site [chemical binding]; other site 573061009967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061009968 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061009969 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 573061009970 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573061009971 NAD binding site [chemical binding]; other site 573061009972 catalytic Zn binding site [ion binding]; other site 573061009973 structural Zn binding site [ion binding]; other site 573061009974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009975 Coenzyme A binding pocket [chemical binding]; other site 573061009976 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573061009977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061009978 DNA binding residues [nucleotide binding] 573061009979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573061009980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 573061009981 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 573061009982 substrate binding site [chemical binding]; other site 573061009983 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573061009984 active site 573061009985 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 573061009986 putative sugar binding sites [chemical binding]; other site 573061009987 Q-X-W motif; other site 573061009988 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061009989 Phosphotransferase enzyme family; Region: APH; pfam01636 573061009990 active site 573061009991 ATP binding site [chemical binding]; other site 573061009992 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061009993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061009994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061009995 Coenzyme A binding pocket [chemical binding]; other site 573061009996 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 573061009997 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061009998 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061009999 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061010000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573061010001 MarR family; Region: MarR_2; pfam12802 573061010002 MarR family; Region: MarR_2; cl17246 573061010003 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573061010004 active site 573061010005 catalytic residues [active] 573061010006 metal binding site [ion binding]; metal-binding site 573061010007 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573061010008 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061010009 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 573061010012 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573061010013 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573061010014 HIGH motif; other site 573061010015 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573061010016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061010017 active site 573061010018 KMSKS motif; other site 573061010019 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573061010020 tRNA binding surface [nucleotide binding]; other site 573061010021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061010022 Coenzyme A binding pocket [chemical binding]; other site 573061010023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 573061010024 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 573061010025 Coenzyme A binding pocket [chemical binding]; other site 573061010026 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 573061010027 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573061010028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010029 FeS/SAM binding site; other site 573061010030 Helix-turn-helix domain; Region: HTH_38; pfam13936 573061010031 Integrase core domain; Region: rve; pfam00665 573061010032 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 573061010033 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 573061010034 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 573061010035 Active_site [active] 573061010036 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 573061010037 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573061010038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061010039 salt bridge; other site 573061010040 non-specific DNA binding site [nucleotide binding]; other site 573061010041 sequence-specific DNA binding site [nucleotide binding]; other site 573061010042 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 573061010043 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 573061010044 CheW-like domain; Region: CheW; pfam01584 573061010045 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573061010046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010047 DNA binding residues [nucleotide binding] 573061010048 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061010049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061010050 Coenzyme A binding pocket [chemical binding]; other site 573061010051 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573061010052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573061010053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573061010056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010057 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010058 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010060 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573061010061 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 573061010062 dUMP phosphatase; Provisional; Region: PRK09449 573061010063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061010064 motif II; other site 573061010065 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061010066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061010067 active site 573061010068 metal binding site [ion binding]; metal-binding site 573061010069 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061010070 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061010071 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061010072 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061010073 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 573061010074 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 573061010075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061010076 active site 573061010077 HIGH motif; other site 573061010078 nucleotide binding site [chemical binding]; other site 573061010079 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 573061010080 KMSKS motif; other site 573061010081 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 573061010082 Cellulose binding domain; Region: CBM_3; pfam00942 573061010083 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061010084 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061010085 dockerin binding interface; other site 573061010086 Cellulose binding domain; Region: CBM_3; pfam00942 573061010087 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 573061010088 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 573061010089 dockerin binding interface; other site 573061010090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061010091 S-adenosylmethionine binding site [chemical binding]; other site 573061010092 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573061010093 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 573061010094 metal binding site [ion binding]; metal-binding site 573061010095 dimer interface [polypeptide binding]; other site 573061010096 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 573061010097 Predicted transcriptional regulators [Transcription]; Region: COG1733 573061010098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061010099 dimerization interface [polypeptide binding]; other site 573061010100 putative DNA binding site [nucleotide binding]; other site 573061010101 putative Zn2+ binding site [ion binding]; other site 573061010102 Predicted membrane protein [Function unknown]; Region: COG3428 573061010103 Bacterial PH domain; Region: DUF304; pfam03703 573061010104 Bacterial PH domain; Region: DUF304; pfam03703 573061010105 Uncharacterized conserved protein [Function unknown]; Region: COG3402 573061010106 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 573061010107 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573061010108 putative ligand binding site [chemical binding]; other site 573061010109 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573061010110 active site 573061010111 catalytic triad [active] 573061010112 oxyanion hole [active] 573061010113 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061010114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061010115 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 573061010116 Walker A/P-loop; other site 573061010117 ATP binding site [chemical binding]; other site 573061010118 Q-loop/lid; other site 573061010119 ABC transporter signature motif; other site 573061010120 Walker B; other site 573061010121 D-loop; other site 573061010122 H-loop/switch region; other site 573061010123 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 573061010124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061010125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010126 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010128 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573061010129 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061010130 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573061010131 DNA binding residues [nucleotide binding] 573061010132 dimer interface [polypeptide binding]; other site 573061010133 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573061010134 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573061010135 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061010136 LytTr DNA-binding domain; Region: LytTR; smart00850 573061010137 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 573061010140 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 573061010141 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 573061010142 putative active site [active] 573061010143 putative NTP binding site [chemical binding]; other site 573061010144 putative nucleic acid binding site [nucleotide binding]; other site 573061010145 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061010146 active site 573061010147 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 573061010148 nucleophile elbow; other site 573061010149 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573061010150 SPFH domain / Band 7 family; Region: Band_7; pfam01145 573061010151 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573061010152 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573061010153 putative active site [active] 573061010154 metal binding site [ion binding]; metal-binding site 573061010155 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 573061010156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061010157 glycogen branching enzyme; Provisional; Region: PRK12313 573061010158 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573061010159 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573061010160 active site 573061010161 catalytic site [active] 573061010162 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573061010163 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573061010164 glycosyltransferase, MGT family; Region: MGT; TIGR01426 573061010165 active site 573061010166 TDP-binding site; other site 573061010167 acceptor substrate-binding pocket; other site 573061010168 homodimer interface [polypeptide binding]; other site 573061010169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573061010170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061010171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061010172 Coenzyme A binding pocket [chemical binding]; other site 573061010173 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 573061010174 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061010175 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573061010176 dimer interface [polypeptide binding]; other site 573061010177 substrate binding site [chemical binding]; other site 573061010178 ATP binding site [chemical binding]; other site 573061010179 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061010180 FMN binding site [chemical binding]; other site 573061010181 dimer interface [polypeptide binding]; other site 573061010182 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061010183 dimer interface [polypeptide binding]; other site 573061010184 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061010185 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573061010186 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061010187 4Fe-4S binding domain; Region: Fer4; pfam00037 573061010188 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573061010189 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573061010190 catalytic residues [active] 573061010191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573061010192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573061010193 catalytic residues [active] 573061010194 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573061010195 Serine hydrolase (FSH1); Region: FSH1; pfam03959 573061010196 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 573061010197 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 573061010198 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 573061010199 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 573061010200 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 573061010201 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 573061010202 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 573061010203 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061010204 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573061010205 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573061010206 substrate binding pocket [chemical binding]; other site 573061010207 chain length determination region; other site 573061010208 substrate-Mg2+ binding site; other site 573061010209 catalytic residues [active] 573061010210 aspartate-rich region 1; other site 573061010211 active site lid residues [active] 573061010212 aspartate-rich region 2; other site 573061010213 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 573061010214 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 573061010215 nucleotide binding site [chemical binding]; other site 573061010216 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573061010217 SBD interface [polypeptide binding]; other site 573061010218 DnaJ domain; Region: DnaJ; pfam00226 573061010219 HSP70 interaction site [polypeptide binding]; other site 573061010220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061010221 binding surface 573061010222 TPR motif; other site 573061010223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061010224 binding surface 573061010225 TPR repeat; Region: TPR_11; pfam13414 573061010226 TPR motif; other site 573061010227 TPR repeat; Region: TPR_11; pfam13414 573061010228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061010229 binding surface 573061010230 TPR motif; other site 573061010231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061010232 binding surface 573061010233 TPR motif; other site 573061010234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061010235 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061010236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061010237 ATP binding site [chemical binding]; other site 573061010238 Mg2+ binding site [ion binding]; other site 573061010239 G-X-G motif; other site 573061010240 amino acid transporter; Region: 2A0306; TIGR00909 573061010241 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 573061010242 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 573061010243 hypothetical protein; Provisional; Region: PRK13665 573061010244 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061010245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061010246 active site 573061010247 phosphorylation site [posttranslational modification] 573061010248 intermolecular recognition site; other site 573061010249 dimerization interface [polypeptide binding]; other site 573061010250 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061010251 Acylphosphatase; Region: Acylphosphatase; pfam00708 573061010252 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 573061010253 HypF finger; Region: zf-HYPF; pfam07503 573061010254 HypF finger; Region: zf-HYPF; pfam07503 573061010255 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573061010256 histidyl-tRNA synthetase; Region: hisS; TIGR00442 573061010257 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573061010258 dimer interface [polypeptide binding]; other site 573061010259 motif 1; other site 573061010260 active site 573061010261 motif 2; other site 573061010262 motif 3; other site 573061010263 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573061010264 anticodon binding site; other site 573061010265 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 573061010266 Putative zinc-finger; Region: zf-HC2; pfam13490 573061010267 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573061010268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061010269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010270 DNA binding residues [nucleotide binding] 573061010271 PAS fold; Region: PAS_3; pfam08447 573061010272 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 573061010273 PAS fold; Region: PAS_4; pfam08448 573061010274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573061010275 putative active site [active] 573061010276 heme pocket [chemical binding]; other site 573061010277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061010278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061010279 dimer interface [polypeptide binding]; other site 573061010280 phosphorylation site [posttranslational modification] 573061010281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061010282 ATP binding site [chemical binding]; other site 573061010283 Mg2+ binding site [ion binding]; other site 573061010284 G-X-G motif; other site 573061010285 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 573061010286 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573061010287 TPP-binding site; other site 573061010288 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573061010289 PYR/PP interface [polypeptide binding]; other site 573061010290 dimer interface [polypeptide binding]; other site 573061010291 TPP binding site [chemical binding]; other site 573061010292 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573061010293 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 573061010294 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061010295 DNA binding residues [nucleotide binding] 573061010296 dimer interface [polypeptide binding]; other site 573061010297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061010298 S-adenosylmethionine binding site [chemical binding]; other site 573061010299 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573061010300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061010301 S-adenosylmethionine binding site [chemical binding]; other site 573061010302 WYL domain; Region: WYL; pfam13280 573061010303 WYL domain; Region: WYL; pfam13280 573061010304 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 573061010305 TROVE domain; Region: TROVE; pfam05731 573061010306 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573061010307 metal ion-dependent adhesion site (MIDAS); other site 573061010308 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 573061010309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573061010310 FMN binding site [chemical binding]; other site 573061010311 active site 573061010312 catalytic residues [active] 573061010313 substrate binding site [chemical binding]; other site 573061010314 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 573061010315 putative active site [active] 573061010316 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 573061010317 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 573061010318 4Fe-4S binding domain; Region: Fer4; pfam00037 573061010319 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 573061010320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573061010321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061010322 myosin-cross-reactive antigen; Provisional; Region: PRK13977 573061010323 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 573061010324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061010325 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573061010326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573061010327 active site 573061010328 HIGH motif; other site 573061010329 nucleotide binding site [chemical binding]; other site 573061010330 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573061010331 active site 573061010332 KMSKS motif; other site 573061010333 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 573061010334 putative active site [active] 573061010335 nucleotide binding site [chemical binding]; other site 573061010336 nudix motif; other site 573061010337 putative metal binding site [ion binding]; other site 573061010338 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 573061010339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061010340 putative substrate translocation pore; other site 573061010341 AIR carboxylase; Region: AIRC; pfam00731 573061010342 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 573061010343 ATP-grasp domain; Region: ATP-grasp; pfam02222 573061010344 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 573061010345 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 573061010346 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573061010347 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573061010348 EamA-like transporter family; Region: EamA; pfam00892 573061010349 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061010350 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061010351 ligand binding site [chemical binding]; other site 573061010352 calcium binding site [ion binding]; other site 573061010353 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573061010354 synthetase active site [active] 573061010355 NTP binding site [chemical binding]; other site 573061010356 metal binding site [ion binding]; metal-binding site 573061010357 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 573061010358 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 573061010359 nudix motif; other site 573061010360 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 573061010361 hybrid cluster protein; Provisional; Region: PRK05290 573061010362 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061010363 ACS interaction site; other site 573061010364 CODH interaction site; other site 573061010365 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 573061010366 hybrid metal cluster; other site 573061010367 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573061010368 flagellin; Provisional; Region: PRK12804 573061010369 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573061010370 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 573061010371 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 573061010372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010373 FeS/SAM binding site; other site 573061010374 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573061010375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010376 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573061010377 FeS/SAM binding site; other site 573061010378 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573061010379 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 573061010380 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 573061010381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061010382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010383 DNA binding residues [nucleotide binding] 573061010384 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573061010385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061010386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010387 DNA binding residues [nucleotide binding] 573061010388 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573061010389 active site 573061010390 catalytic residues [active] 573061010391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573061010392 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573061010393 Survival protein SurE; Region: SurE; cl00448 573061010394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573061010395 Domain of unknown function DUF21; Region: DUF21; pfam01595 573061010396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573061010397 Transporter associated domain; Region: CorC_HlyC; pfam03471 573061010398 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 573061010399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061010400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061010401 active site 573061010402 phosphorylation site [posttranslational modification] 573061010403 intermolecular recognition site; other site 573061010404 dimerization interface [polypeptide binding]; other site 573061010405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061010406 DNA binding site [nucleotide binding] 573061010407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061010408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061010409 dimer interface [polypeptide binding]; other site 573061010410 phosphorylation site [posttranslational modification] 573061010411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061010412 ATP binding site [chemical binding]; other site 573061010413 Mg2+ binding site [ion binding]; other site 573061010414 G-X-G motif; other site 573061010415 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061010416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061010417 Coenzyme A binding pocket [chemical binding]; other site 573061010418 HlyD family secretion protein; Region: HlyD_2; pfam12700 573061010419 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573061010420 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573061010421 E3 interaction surface; other site 573061010422 lipoyl attachment site [posttranslational modification]; other site 573061010423 HlyD family secretion protein; Region: HlyD_3; pfam13437 573061010424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061010425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061010426 Walker A/P-loop; other site 573061010427 ATP binding site [chemical binding]; other site 573061010428 Q-loop/lid; other site 573061010429 ABC transporter signature motif; other site 573061010430 Walker B; other site 573061010431 D-loop; other site 573061010432 H-loop/switch region; other site 573061010433 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061010434 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061010435 FtsX-like permease family; Region: FtsX; pfam02687 573061010436 Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432 573061010437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 573061010438 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573061010439 Peptidase family M23; Region: Peptidase_M23; pfam01551 573061010440 Cache domain; Region: Cache_2; cl07034 573061010441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061010442 dimerization interface [polypeptide binding]; other site 573061010443 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061010444 dimer interface [polypeptide binding]; other site 573061010445 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 573061010446 putative CheW interface [polypeptide binding]; other site 573061010447 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 573061010448 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 573061010449 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061010450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573061010451 metal-binding site [ion binding] 573061010452 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 573061010453 putative homodimer interface [polypeptide binding]; other site 573061010454 putative homotetramer interface [polypeptide binding]; other site 573061010455 putative allosteric switch controlling residues; other site 573061010456 putative metal binding site [ion binding]; other site 573061010457 putative homodimer-homodimer interface [polypeptide binding]; other site 573061010458 BNR repeat-like domain; Region: BNR_2; pfam13088 573061010459 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573061010460 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 573061010461 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573061010462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061010463 Walker A/P-loop; other site 573061010464 ATP binding site [chemical binding]; other site 573061010465 Q-loop/lid; other site 573061010466 ABC transporter signature motif; other site 573061010467 Walker B; other site 573061010468 D-loop; other site 573061010469 H-loop/switch region; other site 573061010470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573061010471 active site residue [active] 573061010472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061010473 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061010474 FtsX-like permease family; Region: FtsX; pfam02687 573061010475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061010476 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061010477 Walker A/P-loop; other site 573061010478 ATP binding site [chemical binding]; other site 573061010479 Q-loop/lid; other site 573061010480 ABC transporter signature motif; other site 573061010481 Walker B; other site 573061010482 D-loop; other site 573061010483 H-loop/switch region; other site 573061010484 HlyD family secretion protein; Region: HlyD_2; pfam12700 573061010485 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061010486 HAMP domain; Region: HAMP; pfam00672 573061010487 dimerization interface [polypeptide binding]; other site 573061010488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061010489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061010490 dimer interface [polypeptide binding]; other site 573061010491 putative CheW interface [polypeptide binding]; other site 573061010492 Hemerythrin; Region: Hemerythrin; cd12107 573061010493 Fe binding site [ion binding]; other site 573061010494 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 573061010495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061010496 substrate binding pocket [chemical binding]; other site 573061010497 membrane-bound complex binding site; other site 573061010498 hinge residues; other site 573061010499 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573061010500 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573061010501 Walker A/P-loop; other site 573061010502 ATP binding site [chemical binding]; other site 573061010503 Q-loop/lid; other site 573061010504 ABC transporter signature motif; other site 573061010505 Walker B; other site 573061010506 D-loop; other site 573061010507 H-loop/switch region; other site 573061010508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061010509 dimer interface [polypeptide binding]; other site 573061010510 conserved gate region; other site 573061010511 ABC-ATPase subunit interface; other site 573061010512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573061010513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061010514 dimer interface [polypeptide binding]; other site 573061010515 conserved gate region; other site 573061010516 putative PBP binding loops; other site 573061010517 ABC-ATPase subunit interface; other site 573061010518 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573061010519 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573061010520 metal binding site [ion binding]; metal-binding site 573061010521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061010522 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061010523 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573061010524 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573061010525 dimer interface [polypeptide binding]; other site 573061010526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061010527 catalytic residue [active] 573061010528 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 573061010529 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573061010530 homodimer interface [polypeptide binding]; other site 573061010531 substrate-cofactor binding pocket; other site 573061010532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061010533 catalytic residue [active] 573061010534 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573061010535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061010536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061010537 homodimer interface [polypeptide binding]; other site 573061010538 catalytic residue [active] 573061010539 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 573061010540 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573061010541 ADP-ribose binding site [chemical binding]; other site 573061010542 dimer interface [polypeptide binding]; other site 573061010543 active site 573061010544 nudix motif; other site 573061010545 metal binding site [ion binding]; metal-binding site 573061010546 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 573061010547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061010548 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 573061010549 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 573061010550 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 573061010551 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 573061010552 active site 573061010553 Isochorismatase family; Region: Isochorismatase; pfam00857 573061010554 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573061010555 catalytic triad [active] 573061010556 conserved cis-peptide bond; other site 573061010557 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934 573061010558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061010559 active site 573061010560 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 573061010561 nudix motif; other site 573061010562 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 573061010563 Response regulator receiver domain; Region: Response_reg; pfam00072 573061010564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061010565 active site 573061010566 phosphorylation site [posttranslational modification] 573061010567 intermolecular recognition site; other site 573061010568 dimerization interface [polypeptide binding]; other site 573061010569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061010572 ATP binding site [chemical binding]; other site 573061010573 Mg2+ binding site [ion binding]; other site 573061010574 G-X-G motif; other site 573061010575 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061010576 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573061010577 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573061010578 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 573061010579 classical (c) SDRs; Region: SDR_c; cd05233 573061010580 NAD(P) binding site [chemical binding]; other site 573061010581 active site 573061010582 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 573061010583 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573061010584 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573061010585 Walker A/P-loop; other site 573061010586 ATP binding site [chemical binding]; other site 573061010587 Q-loop/lid; other site 573061010588 ABC transporter signature motif; other site 573061010589 Walker B; other site 573061010590 D-loop; other site 573061010591 H-loop/switch region; other site 573061010592 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573061010593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061010594 dimer interface [polypeptide binding]; other site 573061010595 conserved gate region; other site 573061010596 putative PBP binding loops; other site 573061010597 ABC-ATPase subunit interface; other site 573061010598 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573061010599 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 573061010600 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 573061010601 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 573061010602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573061010603 nitrogenase iron protein; Region: nifH; TIGR01287 573061010604 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 573061010605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 573061010606 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 573061010607 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573061010608 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573061010609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010610 FeS/SAM binding site; other site 573061010611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061010612 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061010613 putative substrate translocation pore; other site 573061010614 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573061010615 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 573061010616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573061010617 substrate binding pocket [chemical binding]; other site 573061010618 membrane-bound complex binding site; other site 573061010619 hinge residues; other site 573061010620 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573061010621 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573061010622 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573061010623 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573061010624 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061010625 Rubrerythrin [Energy production and conversion]; Region: COG1592 573061010626 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573061010627 binuclear metal center [ion binding]; other site 573061010628 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573061010629 iron binding site [ion binding]; other site 573061010630 Predicted ATPase [General function prediction only]; Region: COG3910 573061010631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061010632 Walker A/P-loop; other site 573061010633 ATP binding site [chemical binding]; other site 573061010634 Q-loop/lid; other site 573061010635 ABC transporter signature motif; other site 573061010636 Walker B; other site 573061010637 D-loop; other site 573061010638 H-loop/switch region; other site 573061010639 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 573061010640 dimer interface [polypeptide binding]; other site 573061010641 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 573061010642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573061010643 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061010644 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061010645 Peptidase M15; Region: Peptidase_M15_3; cl01194 573061010646 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061010647 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061010648 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 573061010649 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 573061010650 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 573061010651 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 573061010652 nudix motif; other site 573061010653 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 573061010654 plasmid segregation protein ParM; Provisional; Region: PRK13917 573061010655 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 573061010656 Mg binding site [ion binding]; other site 573061010657 nucleotide binding site [chemical binding]; other site 573061010658 putative protofilament interface [polypeptide binding]; other site 573061010659 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573061010660 amidase catalytic site [active] 573061010661 Zn binding residues [ion binding]; other site 573061010662 substrate binding site [chemical binding]; other site 573061010663 Phage Tail Collar Domain; Region: Collar; pfam07484 573061010664 pectinesterase/pectinesterase inhibitor; Region: PLN02301 573061010665 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 573061010666 Phage-related protein [Function unknown]; Region: COG4722 573061010667 Phage tail protein; Region: Sipho_tail; cl17486 573061010668 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 573061010669 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 573061010670 Minor capsid protein; Region: Minor_capsid_2; pfam11114 573061010671 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 573061010672 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 573061010673 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 573061010674 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 573061010675 active site 573061010676 conformational flexibility of ligand binding pocket; other site 573061010677 ADP-ribosylating toxin turn-turn motif; other site 573061010678 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 573061010679 BRO family, N-terminal domain; Region: Bro-N; cl10591 573061010680 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 573061010681 Transposase; Region: HTH_Tnp_IS630; pfam01710 573061010682 Homeodomain-like domain; Region: HTH_23; pfam13384 573061010683 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 573061010684 GIY-YIG motif/motif A; other site 573061010685 active site 573061010686 catalytic site [active] 573061010687 metal binding site [ion binding]; metal-binding site 573061010688 CHC2 zinc finger; Region: zf-CHC2; cl17510 573061010689 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 573061010690 active site 573061010691 metal binding site [ion binding]; metal-binding site 573061010692 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 573061010693 homodimer interface [polypeptide binding]; other site 573061010694 metal binding site [ion binding]; metal-binding site 573061010695 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 573061010696 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573061010697 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573061010698 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573061010699 dimer interface [polypeptide binding]; other site 573061010700 ssDNA binding site [nucleotide binding]; other site 573061010701 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061010702 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 573061010703 RecT family; Region: RecT; cl04285 573061010704 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 573061010705 hypothetical protein; Provisional; Region: PRK09946 573061010706 hypothetical protein; Provisional; Region: PRK09946 573061010707 Helix-turn-helix domain; Region: HTH_17; pfam12728 573061010708 Prophage antirepressor [Transcription]; Region: COG3617 573061010709 BRO family, N-terminal domain; Region: Bro-N; smart01040 573061010710 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 573061010711 Helix-turn-helix domain; Region: HTH_17; pfam12728 573061010712 BRO family, N-terminal domain; Region: Bro-N; smart01040 573061010713 BRO family, N-terminal domain; Region: Bro-N; smart01040 573061010714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061010715 non-specific DNA binding site [nucleotide binding]; other site 573061010716 salt bridge; other site 573061010717 sequence-specific DNA binding site [nucleotide binding]; other site 573061010718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061010719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061010720 non-specific DNA binding site [nucleotide binding]; other site 573061010721 salt bridge; other site 573061010722 sequence-specific DNA binding site [nucleotide binding]; other site 573061010723 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573061010724 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573061010725 active site 573061010726 DNA binding site [nucleotide binding] 573061010727 Int/Topo IB signature motif; other site 573061010728 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 573061010729 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 573061010730 nudix motif; other site 573061010731 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 573061010732 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061010733 Zn2+ binding site [ion binding]; other site 573061010734 Mg2+ binding site [ion binding]; other site 573061010735 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573061010736 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573061010737 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 573061010738 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 573061010739 Hemerythrin-like domain; Region: Hr-like; cd12108 573061010740 Fe binding site [ion binding]; other site 573061010741 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 573061010742 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573061010743 putative FMN binding site [chemical binding]; other site 573061010744 NADPH bind site [chemical binding]; other site 573061010745 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573061010746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061010747 ATP binding site [chemical binding]; other site 573061010748 putative Mg++ binding site [ion binding]; other site 573061010749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061010750 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573061010751 nucleotide binding region [chemical binding]; other site 573061010752 ATP-binding site [chemical binding]; other site 573061010753 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 573061010754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061010755 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573061010756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010757 DNA binding residues [nucleotide binding] 573061010758 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061010759 active site 573061010760 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573061010761 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 573061010762 RHS Repeat; Region: RHS_repeat; pfam05593 573061010763 RHS Repeat; Region: RHS_repeat; pfam05593 573061010764 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573061010765 RHS Repeat; Region: RHS_repeat; pfam05593 573061010766 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061010767 RHS Repeat; Region: RHS_repeat; pfam05593 573061010768 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061010769 RHS Repeat; Region: RHS_repeat; pfam05593 573061010770 RHS Repeat; Region: RHS_repeat; pfam05593 573061010771 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061010772 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573061010773 RHS Repeat; Region: RHS_repeat; pfam05593 573061010774 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061010775 RHS Repeat; Region: RHS_repeat; cl11982 573061010776 RHS Repeat; Region: RHS_repeat; pfam05593 573061010777 RHS Repeat; Region: RHS_repeat; pfam05593 573061010778 RHS Repeat; Region: RHS_repeat; pfam05593 573061010779 RHS Repeat; Region: RHS_repeat; cl11982 573061010780 RHS Repeat; Region: RHS_repeat; pfam05593 573061010781 RHS Repeat; Region: RHS_repeat; cl11982 573061010782 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 573061010783 RHS Repeat; Region: RHS_repeat; pfam05593 573061010784 RHS Repeat; Region: RHS_repeat; pfam05593 573061010785 RHS Repeat; Region: RHS_repeat; pfam05593 573061010786 RHS Repeat; Region: RHS_repeat; pfam05593 573061010787 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573061010788 RHS Repeat; Region: RHS_repeat; pfam05593 573061010789 RHS Repeat; Region: RHS_repeat; pfam05593 573061010790 RHS Repeat; Region: RHS_repeat; pfam05593 573061010791 RHS Repeat; Region: RHS_repeat; pfam05593 573061010792 RHS Repeat; Region: RHS_repeat; pfam05593 573061010793 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573061010794 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 573061010795 protein-splicing catalytic site; other site 573061010796 thioester formation/cholesterol transfer; other site 573061010797 Pretoxin HINT domain; Region: PT-HINT; pfam07591 573061010798 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061010799 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573061010800 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 573061010801 Protein export membrane protein; Region: SecD_SecF; cl14618 573061010802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061010803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061010804 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 573061010805 lysine transporter; Provisional; Region: PRK10836 573061010806 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061010807 putative metal binding site [ion binding]; other site 573061010808 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573061010809 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061010810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061010811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061010812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573061010813 dimerization interface [polypeptide binding]; other site 573061010814 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 573061010815 active site 573061010816 catalytic triad [active] 573061010817 oxyanion hole [active] 573061010818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061010819 S-adenosylmethionine binding site [chemical binding]; other site 573061010820 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 573061010821 active site flap/lid [active] 573061010822 nucleophilic elbow; other site 573061010823 catalytic triad [active] 573061010824 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 573061010825 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573061010826 inhibitor-cofactor binding pocket; inhibition site 573061010827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061010828 catalytic residue [active] 573061010829 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 573061010830 classical (c) SDRs; Region: SDR_c; cd05233 573061010831 NAD(P) binding site [chemical binding]; other site 573061010832 active site 573061010833 uncharacterized domain; Region: TIGR00702 573061010834 YcaO-like family; Region: YcaO; pfam02624 573061010835 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573061010836 putative FMN binding site [chemical binding]; other site 573061010837 NADPH bind site [chemical binding]; other site 573061010838 SpaB C-terminal domain; Region: SpaB_C; pfam14028 573061010839 YcaO-like family; Region: YcaO; pfam02624 573061010840 SpaB C-terminal domain; Region: SpaB_C; pfam14028 573061010841 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 573061010842 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 573061010843 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573061010844 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573061010845 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573061010846 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061010847 Walker A/P-loop; other site 573061010848 ATP binding site [chemical binding]; other site 573061010849 Q-loop/lid; other site 573061010850 ABC transporter signature motif; other site 573061010851 Walker B; other site 573061010852 D-loop; other site 573061010853 H-loop/switch region; other site 573061010854 alpha-galactosidase; Region: PLN02808; cl17638 573061010855 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061010856 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061010857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010858 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 573061010859 VanZ like family; Region: VanZ; cl01971 573061010860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061010861 dimer interface [polypeptide binding]; other site 573061010862 putative CheW interface [polypeptide binding]; other site 573061010863 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 573061010864 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573061010865 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 573061010866 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 573061010867 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061010868 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061010869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010872 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061010873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061010874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061010875 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573061010876 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573061010877 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573061010878 active site 573061010879 catalytic tetrad [active] 573061010880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061010881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573061010882 active site 573061010883 metal binding site [ion binding]; metal-binding site 573061010884 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 573061010885 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573061010886 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573061010887 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573061010888 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 573061010889 inhibitor binding site; inhibition site 573061010890 active site 573061010891 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 573061010892 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061010893 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573061010894 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 573061010895 Beta propeller domain; Region: Beta_propel; pfam09826 573061010896 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 573061010897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061010898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061010899 DNA binding residues [nucleotide binding] 573061010900 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 573061010901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010902 FeS/SAM binding site; other site 573061010903 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061010904 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573061010905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061010906 FeS/SAM binding site; other site 573061010907 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061010908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573061010909 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573061010910 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573061010911 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573061010912 glutaminase active site [active] 573061010913 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573061010914 dimer interface [polypeptide binding]; other site 573061010915 active site 573061010916 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573061010917 dimer interface [polypeptide binding]; other site 573061010918 active site 573061010919 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 573061010920 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573061010921 Transcriptional regulator [Transcription]; Region: LytR; COG1316 573061010922 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 573061010923 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573061010924 active site 573061010925 substrate binding site [chemical binding]; other site 573061010926 metal binding site [ion binding]; metal-binding site 573061010927 Trp repressor protein; Region: Trp_repressor; cl17266 573061010928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573061010929 nucleotide binding site [chemical binding]; other site 573061010930 Acetokinase family; Region: Acetate_kinase; cl17229 573061010931 phosphate butyryltransferase; Validated; Region: PRK05805 573061010932 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 573061010933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061010934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 573061010935 YbbR-like protein; Region: YbbR; pfam07949 573061010936 Uncharacterized conserved protein [Function unknown]; Region: COG1624 573061010937 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573061010938 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 573061010939 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573061010940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061010941 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573061010942 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573061010943 catalytic residues [active] 573061010944 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 573061010945 Tetratricopeptide repeat; Region: TPR_2; pfam07719 573061010946 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573061010947 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573061010948 trimer interface [polypeptide binding]; other site 573061010949 active site 573061010950 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573061010951 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573061010952 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573061010953 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573061010954 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573061010955 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573061010956 active site 573061010957 metal binding site [ion binding]; metal-binding site 573061010958 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 573061010959 dimer interface [polypeptide binding]; other site 573061010960 Citrate synthase; Region: Citrate_synt; pfam00285 573061010961 active site 573061010962 citrylCoA binding site [chemical binding]; other site 573061010963 oxalacetate/citrate binding site [chemical binding]; other site 573061010964 coenzyme A binding site [chemical binding]; other site 573061010965 catalytic triad [active] 573061010966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061010967 non-specific DNA binding site [nucleotide binding]; other site 573061010968 salt bridge; other site 573061010969 sequence-specific DNA binding site [nucleotide binding]; other site 573061010970 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573061010971 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573061010972 active site 573061010973 catalytic tetrad [active] 573061010974 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573061010975 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 573061010976 DNA binding residues [nucleotide binding] 573061010977 putative dimer interface [polypeptide binding]; other site 573061010978 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 573061010979 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573061010980 transmembrane helices; other site 573061010981 Phosphotransferase enzyme family; Region: APH; pfam01636 573061010982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061010983 active site 573061010984 substrate binding site [chemical binding]; other site 573061010985 ATP binding site [chemical binding]; other site 573061010986 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 573061010987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573061010988 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573061010989 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573061010990 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573061010991 23S rRNA interface [nucleotide binding]; other site 573061010992 L3 interface [polypeptide binding]; other site 573061010993 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573061010994 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573061010995 dimerization interface 3.5A [polypeptide binding]; other site 573061010996 active site 573061010997 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573061010998 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 573061010999 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573061011000 Walker A/P-loop; other site 573061011001 ATP binding site [chemical binding]; other site 573061011002 Q-loop/lid; other site 573061011003 ABC transporter signature motif; other site 573061011004 Walker B; other site 573061011005 D-loop; other site 573061011006 H-loop/switch region; other site 573061011007 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 573061011008 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573061011009 Walker A/P-loop; other site 573061011010 ATP binding site [chemical binding]; other site 573061011011 Q-loop/lid; other site 573061011012 ABC transporter signature motif; other site 573061011013 Walker B; other site 573061011014 D-loop; other site 573061011015 H-loop/switch region; other site 573061011016 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573061011017 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573061011018 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573061011019 alphaNTD homodimer interface [polypeptide binding]; other site 573061011020 alphaNTD - beta interaction site [polypeptide binding]; other site 573061011021 alphaNTD - beta' interaction site [polypeptide binding]; other site 573061011022 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573061011023 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573061011024 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573061011025 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061011026 RNA binding surface [nucleotide binding]; other site 573061011027 30S ribosomal protein S11; Validated; Region: PRK05309 573061011028 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 573061011029 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573061011030 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 573061011031 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573061011032 rRNA binding site [nucleotide binding]; other site 573061011033 predicted 30S ribosome binding site; other site 573061011034 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 573061011035 RNA binding site [nucleotide binding]; other site 573061011036 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573061011037 active site 573061011038 adenylate kinase; Reviewed; Region: adk; PRK00279 573061011039 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573061011040 AMP-binding site [chemical binding]; other site 573061011041 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573061011042 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573061011043 SecY translocase; Region: SecY; pfam00344 573061011044 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573061011045 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573061011046 23S rRNA binding site [nucleotide binding]; other site 573061011047 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573061011048 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573061011049 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573061011050 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573061011051 5S rRNA interface [nucleotide binding]; other site 573061011052 L27 interface [polypeptide binding]; other site 573061011053 23S rRNA interface [nucleotide binding]; other site 573061011054 L5 interface [polypeptide binding]; other site 573061011055 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573061011056 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573061011057 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573061011058 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573061011059 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 573061011060 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573061011061 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573061011062 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573061011063 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573061011064 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573061011065 RNA binding site [nucleotide binding]; other site 573061011066 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573061011067 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573061011068 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573061011069 23S rRNA interface [nucleotide binding]; other site 573061011070 putative translocon interaction site; other site 573061011071 signal recognition particle (SRP54) interaction site; other site 573061011072 L23 interface [polypeptide binding]; other site 573061011073 trigger factor interaction site; other site 573061011074 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573061011075 23S rRNA interface [nucleotide binding]; other site 573061011076 5S rRNA interface [nucleotide binding]; other site 573061011077 putative antibiotic binding site [chemical binding]; other site 573061011078 L25 interface [polypeptide binding]; other site 573061011079 L27 interface [polypeptide binding]; other site 573061011080 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573061011081 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573061011082 G-X-X-G motif; other site 573061011083 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573061011084 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573061011085 putative translocon binding site; other site 573061011086 protein-rRNA interface [nucleotide binding]; other site 573061011087 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573061011088 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573061011089 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573061011090 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573061011091 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573061011092 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573061011093 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573061011094 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573061011095 elongation factor Tu; Reviewed; Region: PRK00049 573061011096 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573061011097 G1 box; other site 573061011098 GEF interaction site [polypeptide binding]; other site 573061011099 GTP/Mg2+ binding site [chemical binding]; other site 573061011100 Switch I region; other site 573061011101 G2 box; other site 573061011102 G3 box; other site 573061011103 Switch II region; other site 573061011104 G4 box; other site 573061011105 G5 box; other site 573061011106 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573061011107 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573061011108 Antibiotic Binding Site [chemical binding]; other site 573061011109 elongation factor G; Reviewed; Region: PRK00007 573061011110 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573061011111 G1 box; other site 573061011112 putative GEF interaction site [polypeptide binding]; other site 573061011113 GTP/Mg2+ binding site [chemical binding]; other site 573061011114 Switch I region; other site 573061011115 G2 box; other site 573061011116 G3 box; other site 573061011117 Switch II region; other site 573061011118 G4 box; other site 573061011119 G5 box; other site 573061011120 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573061011121 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573061011122 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573061011123 30S ribosomal protein S7; Validated; Region: PRK05302 573061011124 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573061011125 S17 interaction site [polypeptide binding]; other site 573061011126 S8 interaction site; other site 573061011127 16S rRNA interaction site [nucleotide binding]; other site 573061011128 streptomycin interaction site [chemical binding]; other site 573061011129 23S rRNA interaction site [nucleotide binding]; other site 573061011130 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573061011131 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 573061011132 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573061011133 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 573061011134 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573061011135 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573061011136 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573061011137 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573061011138 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 573061011139 G-loop; other site 573061011140 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573061011141 DNA binding site [nucleotide binding] 573061011142 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573061011143 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573061011144 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573061011145 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 573061011146 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573061011147 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 573061011148 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573061011149 RPB1 interaction site [polypeptide binding]; other site 573061011150 RPB10 interaction site [polypeptide binding]; other site 573061011151 RPB11 interaction site [polypeptide binding]; other site 573061011152 RPB3 interaction site [polypeptide binding]; other site 573061011153 RPB12 interaction site [polypeptide binding]; other site 573061011154 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573061011155 core dimer interface [polypeptide binding]; other site 573061011156 peripheral dimer interface [polypeptide binding]; other site 573061011157 L10 interface [polypeptide binding]; other site 573061011158 L11 interface [polypeptide binding]; other site 573061011159 putative EF-Tu interaction site [polypeptide binding]; other site 573061011160 putative EF-G interaction site [polypeptide binding]; other site 573061011161 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573061011162 23S rRNA interface [nucleotide binding]; other site 573061011163 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573061011164 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573061011165 mRNA/rRNA interface [nucleotide binding]; other site 573061011166 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573061011167 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573061011168 23S rRNA interface [nucleotide binding]; other site 573061011169 L7/L12 interface [polypeptide binding]; other site 573061011170 putative thiostrepton binding site; other site 573061011171 L25 interface [polypeptide binding]; other site 573061011172 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573061011173 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573061011174 putative homodimer interface [polypeptide binding]; other site 573061011175 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573061011176 heterodimer interface [polypeptide binding]; other site 573061011177 homodimer interface [polypeptide binding]; other site 573061011178 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 573061011179 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 573061011180 elongation factor Tu; Reviewed; Region: PRK00049 573061011181 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573061011182 G1 box; other site 573061011183 GEF interaction site [polypeptide binding]; other site 573061011184 GTP/Mg2+ binding site [chemical binding]; other site 573061011185 Switch I region; other site 573061011186 G2 box; other site 573061011187 G3 box; other site 573061011188 Switch II region; other site 573061011189 G4 box; other site 573061011190 G5 box; other site 573061011191 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573061011192 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573061011193 Antibiotic Binding Site [chemical binding]; other site 573061011194 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 573061011195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061011196 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 573061011197 YacP-like NYN domain; Region: NYN_YacP; pfam05991 573061011198 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573061011199 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573061011200 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573061011201 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573061011202 active site 573061011203 metal binding site [ion binding]; metal-binding site 573061011204 dimerization interface [polypeptide binding]; other site 573061011205 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573061011206 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573061011207 dimer interface [polypeptide binding]; other site 573061011208 motif 1; other site 573061011209 active site 573061011210 motif 2; other site 573061011211 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573061011212 putative deacylase active site [active] 573061011213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573061011214 active site 573061011215 motif 3; other site 573061011216 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573061011217 anticodon binding site; other site 573061011218 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573061011219 substrate binding site; other site 573061011220 dimer interface; other site 573061011221 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 573061011222 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 573061011223 putative active site [active] 573061011224 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 573061011225 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 573061011226 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573061011227 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 573061011228 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 573061011229 DNA repair protein RadA; Provisional; Region: PRK11823 573061011230 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 573061011231 Walker A motif/ATP binding site; other site 573061011232 ATP binding site [chemical binding]; other site 573061011233 Walker B motif; other site 573061011234 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573061011235 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 573061011236 Clp amino terminal domain; Region: Clp_N; pfam02861 573061011237 Clp amino terminal domain; Region: Clp_N; pfam02861 573061011238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061011239 Walker A motif; other site 573061011240 ATP binding site [chemical binding]; other site 573061011241 Walker B motif; other site 573061011242 arginine finger; other site 573061011243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061011244 Walker A motif; other site 573061011245 ATP binding site [chemical binding]; other site 573061011246 Walker B motif; other site 573061011247 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573061011248 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 573061011249 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 573061011250 ADP binding site [chemical binding]; other site 573061011251 phosphagen binding site; other site 573061011252 substrate specificity loop; other site 573061011253 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 573061011254 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 573061011255 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573061011256 catalytic core [active] 573061011257 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573061011258 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573061011259 nucleotide binding site [chemical binding]; other site 573061011260 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 573061011261 tetramerization interface [polypeptide binding]; other site 573061011262 active site 573061011263 Pantoate-beta-alanine ligase; Region: PanC; cd00560 573061011264 pantoate--beta-alanine ligase; Region: panC; TIGR00018 573061011265 active site 573061011266 ATP-binding site [chemical binding]; other site 573061011267 pantoate-binding site; other site 573061011268 HXXH motif; other site 573061011269 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573061011270 oligomerization interface [polypeptide binding]; other site 573061011271 active site 573061011272 metal binding site [ion binding]; metal-binding site 573061011273 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 573061011274 elongation factor G; Reviewed; Region: PRK12740 573061011275 G1 box; other site 573061011276 putative GEF interaction site [polypeptide binding]; other site 573061011277 GTP/Mg2+ binding site [chemical binding]; other site 573061011278 Switch I region; other site 573061011279 G2 box; other site 573061011280 G3 box; other site 573061011281 Switch II region; other site 573061011282 G4 box; other site 573061011283 G5 box; other site 573061011284 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573061011285 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573061011286 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573061011287 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573061011288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061011289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061011290 DNA binding residues [nucleotide binding] 573061011291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573061011292 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573061011293 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 573061011294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061011295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061011296 glycyl-tRNA synthetase; Provisional; Region: PRK04173 573061011297 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573061011298 motif 1; other site 573061011299 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 573061011300 active site 573061011301 motif 2; other site 573061011302 motif 3; other site 573061011303 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 573061011304 anticodon binding site; other site 573061011305 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 573061011306 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573061011307 dimer interface [polypeptide binding]; other site 573061011308 putative anticodon binding site; other site 573061011309 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 573061011310 motif 1; other site 573061011311 active site 573061011312 motif 2; other site 573061011313 motif 3; other site 573061011314 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573061011315 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573061011316 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573061011317 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 573061011318 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573061011319 FMN binding site [chemical binding]; other site 573061011320 active site 573061011321 catalytic residues [active] 573061011322 substrate binding site [chemical binding]; other site 573061011323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573061011324 nucleotide binding site [chemical binding]; other site 573061011325 Type III pantothenate kinase; Region: Pan_kinase; cl17198 573061011326 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 573061011327 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 573061011328 Potassium binding sites [ion binding]; other site 573061011329 Cesium cation binding sites [ion binding]; other site 573061011330 FtsH Extracellular; Region: FtsH_ext; pfam06480 573061011331 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573061011332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061011333 Walker A motif; other site 573061011334 ATP binding site [chemical binding]; other site 573061011335 Walker B motif; other site 573061011336 arginine finger; other site 573061011337 Peptidase family M41; Region: Peptidase_M41; pfam01434 573061011338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061011339 active site 573061011340 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573061011341 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573061011342 Ligand Binding Site [chemical binding]; other site 573061011343 TilS substrate C-terminal domain; Region: TilS_C; smart00977 573061011344 stage II sporulation protein E; Region: spore_II_E; TIGR02865 573061011345 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573061011346 Transposase IS200 like; Region: Y1_Tnp; pfam01797 573061011347 Sm and related proteins; Region: Sm_like; cl00259 573061011348 heptamer interface [polypeptide binding]; other site 573061011349 Sm1 motif; other site 573061011350 hexamer interface [polypeptide binding]; other site 573061011351 RNA binding site [nucleotide binding]; other site 573061011352 Sm2 motif; other site 573061011353 hypothetical protein; Provisional; Region: PRK05807 573061011354 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 573061011355 RNA binding site [nucleotide binding]; other site 573061011356 Septum formation initiator; Region: DivIC; pfam04977 573061011357 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 573061011358 YabP family; Region: YabP; cl06766 573061011359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573061011360 RNA binding surface [nucleotide binding]; other site 573061011361 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573061011362 IHF dimer interface [polypeptide binding]; other site 573061011363 IHF - DNA interface [nucleotide binding]; other site 573061011364 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 573061011365 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 573061011366 putative SAM binding site [chemical binding]; other site 573061011367 putative homodimer interface [polypeptide binding]; other site 573061011368 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 573061011369 homodimer interface [polypeptide binding]; other site 573061011370 metal binding site [ion binding]; metal-binding site 573061011371 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 573061011372 homodimer interface [polypeptide binding]; other site 573061011373 active site 573061011374 putative chemical substrate binding site [chemical binding]; other site 573061011375 metal binding site [ion binding]; metal-binding site 573061011376 stage V sporulation protein B; Region: spore_V_B; TIGR02900 573061011377 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 573061011378 stage V sporulation protein T; Region: spore_V_T; TIGR02851 573061011379 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 573061011380 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 573061011381 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573061011382 SurA N-terminal domain; Region: SurA_N_3; cl07813 573061011383 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573061011384 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573061011385 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573061011386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061011387 ATP binding site [chemical binding]; other site 573061011388 putative Mg++ binding site [ion binding]; other site 573061011389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573061011390 nucleotide binding region [chemical binding]; other site 573061011391 ATP-binding site [chemical binding]; other site 573061011392 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573061011393 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573061011394 putative active site [active] 573061011395 catalytic residue [active] 573061011396 Per1-like; Region: Per1; cl02172 573061011397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061011398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061011399 dimer interface [polypeptide binding]; other site 573061011400 phosphorylation site [posttranslational modification] 573061011401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061011402 ATP binding site [chemical binding]; other site 573061011403 Mg2+ binding site [ion binding]; other site 573061011404 G-X-G motif; other site 573061011405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061011406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061011407 active site 573061011408 phosphorylation site [posttranslational modification] 573061011409 intermolecular recognition site; other site 573061011410 dimerization interface [polypeptide binding]; other site 573061011411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061011412 DNA binding site [nucleotide binding] 573061011413 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 573061011414 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573061011415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061011416 active site 573061011417 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 573061011418 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573061011419 Substrate binding site; other site 573061011420 Mg++ binding site; other site 573061011421 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573061011422 active site 573061011423 substrate binding site [chemical binding]; other site 573061011424 CoA binding site [chemical binding]; other site 573061011425 regulatory protein SpoVG; Reviewed; Region: PRK13259 573061011426 pur operon repressor; Provisional; Region: PRK09213 573061011427 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 573061011428 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573061011429 active site 573061011430 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573061011431 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573061011432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573061011433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573061011434 aspartate aminotransferase; Provisional; Region: PRK07568 573061011435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061011436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061011437 homodimer interface [polypeptide binding]; other site 573061011438 catalytic residue [active] 573061011439 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 573061011440 4Fe-4S binding domain; Region: Fer4; pfam00037 573061011441 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573061011442 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573061011443 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573061011444 active site 573061011445 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 573061011446 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061011447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061011448 motif II; other site 573061011449 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573061011450 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 573061011451 putative active site [active] 573061011452 metal binding site [ion binding]; metal-binding site 573061011453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061011454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061011455 S-adenosylmethionine binding site [chemical binding]; other site 573061011456 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061011457 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011458 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011459 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573061011460 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 573061011461 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 573061011462 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061011463 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573061011464 Phosphotransferase enzyme family; Region: APH; pfam01636 573061011465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061011466 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061011467 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061011468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061011469 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573061011470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061011471 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573061011472 Coenzyme A binding pocket [chemical binding]; other site 573061011473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061011474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061011475 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573061011476 Walker A/P-loop; other site 573061011477 ATP binding site [chemical binding]; other site 573061011478 Q-loop/lid; other site 573061011479 ABC transporter signature motif; other site 573061011480 Walker B; other site 573061011481 D-loop; other site 573061011482 H-loop/switch region; other site 573061011483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061011484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061011485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061011486 Walker A/P-loop; other site 573061011487 ATP binding site [chemical binding]; other site 573061011488 Q-loop/lid; other site 573061011489 ABC transporter signature motif; other site 573061011490 Walker B; other site 573061011491 D-loop; other site 573061011492 H-loop/switch region; other site 573061011493 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573061011494 MarR family; Region: MarR_2; pfam12802 573061011495 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573061011496 CoenzymeA binding site [chemical binding]; other site 573061011497 subunit interaction site [polypeptide binding]; other site 573061011498 PHB binding site; other site 573061011499 Pectic acid lyase; Region: Pec_lyase; pfam09492 573061011500 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 573061011501 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061011502 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573061011503 TM-ABC transporter signature motif; other site 573061011504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573061011505 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 573061011506 Walker A/P-loop; other site 573061011507 ATP binding site [chemical binding]; other site 573061011508 Q-loop/lid; other site 573061011509 ABC transporter signature motif; other site 573061011510 Walker B; other site 573061011511 D-loop; other site 573061011512 H-loop/switch region; other site 573061011513 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573061011514 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 573061011515 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061011516 ligand binding site [chemical binding]; other site 573061011517 calcium binding site [ion binding]; other site 573061011518 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 573061011519 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573061011520 ligand binding site [chemical binding]; other site 573061011521 calcium binding site [ion binding]; other site 573061011522 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 573061011523 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573061011524 putative ligand binding site [chemical binding]; other site 573061011525 Cache domain; Region: Cache_1; pfam02743 573061011526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061011527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061011528 dimerization interface [polypeptide binding]; other site 573061011529 Histidine kinase; Region: His_kinase; pfam06580 573061011530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061011531 ATP binding site [chemical binding]; other site 573061011532 Mg2+ binding site [ion binding]; other site 573061011533 G-X-G motif; other site 573061011534 Response regulator receiver domain; Region: Response_reg; pfam00072 573061011535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061011536 active site 573061011537 phosphorylation site [posttranslational modification] 573061011538 intermolecular recognition site; other site 573061011539 dimerization interface [polypeptide binding]; other site 573061011540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061011541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061011542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061011543 Predicted membrane protein [Function unknown]; Region: COG4129 573061011544 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 573061011545 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 573061011546 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 573061011547 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 573061011548 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061011549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061011550 putative DNA binding site [nucleotide binding]; other site 573061011551 putative Zn2+ binding site [ion binding]; other site 573061011552 Uncharacterized conserved protein [Function unknown]; Region: COG3603 573061011553 Family description; Region: ACT_7; pfam13840 573061011554 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 573061011555 putative active site [active] 573061011556 putative metal binding site [ion binding]; other site 573061011557 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 573061011558 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 573061011559 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 573061011560 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 573061011561 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061011562 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061011563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061011564 ABC transporter; Region: ABC_tran_2; pfam12848 573061011565 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061011566 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 573061011567 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 573061011568 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 573061011569 putative RNA binding site [nucleotide binding]; other site 573061011570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061011571 S-adenosylmethionine binding site [chemical binding]; other site 573061011572 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573061011573 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573061011574 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573061011575 Walker A/P-loop; other site 573061011576 ATP binding site [chemical binding]; other site 573061011577 Q-loop/lid; other site 573061011578 ABC transporter signature motif; other site 573061011579 Walker B; other site 573061011580 D-loop; other site 573061011581 H-loop/switch region; other site 573061011582 TOBE domain; Region: TOBE_2; pfam08402 573061011583 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 573061011584 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 573061011585 Uncharacterized membrane protein [Function unknown]; Region: COG3949 573061011586 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 573061011587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061011588 FeS/SAM binding site; other site 573061011589 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061011590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011591 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061011592 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011593 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061011594 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011595 Stage II sporulation protein; Region: SpoIID; pfam08486 573061011596 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 573061011597 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573061011598 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 573061011599 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 573061011600 active site 573061011601 catalytic triad [active] 573061011602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061011603 non-specific DNA binding site [nucleotide binding]; other site 573061011604 salt bridge; other site 573061011605 sequence-specific DNA binding site [nucleotide binding]; other site 573061011606 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573061011607 Catalytic site [active] 573061011608 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 573061011609 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573061011610 active site 573061011611 glutamate racemase; Provisional; Region: PRK00865 573061011612 glutamine synthetase, type I; Region: GlnA; TIGR00653 573061011613 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573061011614 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 573061011615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061011616 Zn2+ binding site [ion binding]; other site 573061011617 Mg2+ binding site [ion binding]; other site 573061011618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 573061011619 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 573061011620 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061011621 putative active site [active] 573061011622 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 573061011623 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 573061011624 putative dimer interface [polypeptide binding]; other site 573061011625 putative anticodon binding site; other site 573061011626 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 573061011627 homodimer interface [polypeptide binding]; other site 573061011628 motif 1; other site 573061011629 motif 2; other site 573061011630 active site 573061011631 motif 3; other site 573061011632 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 573061011633 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 573061011634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573061011635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061011636 Zn2+ binding site [ion binding]; other site 573061011637 Mg2+ binding site [ion binding]; other site 573061011638 CAT RNA binding domain; Region: CAT_RBD; smart01061 573061011639 transcriptional antiterminator BglG; Provisional; Region: PRK09772 573061011640 PRD domain; Region: PRD; pfam00874 573061011641 PRD domain; Region: PRD; pfam00874 573061011642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573061011643 DNA-binding site [nucleotide binding]; DNA binding site 573061011644 RNA-binding motif; other site 573061011645 AAA ATPase domain; Region: AAA_16; pfam13191 573061011646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061011647 TPR motif; other site 573061011648 binding surface 573061011649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573061011650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061011651 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573061011652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061011653 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573061011654 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573061011655 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573061011656 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573061011657 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573061011658 folate binding site [chemical binding]; other site 573061011659 NADP+ binding site [chemical binding]; other site 573061011660 thymidylate synthase; Reviewed; Region: thyA; PRK01827 573061011661 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 573061011662 dimerization interface [polypeptide binding]; other site 573061011663 active site 573061011664 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 573061011665 Interferon-induced transmembrane protein; Region: CD225; pfam04505 573061011666 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 573061011667 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 573061011668 Interferon-induced transmembrane protein; Region: CD225; pfam04505 573061011669 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 573061011670 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573061011671 active site 573061011672 dimer interface [polypeptide binding]; other site 573061011673 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573061011674 Ligand Binding Site [chemical binding]; other site 573061011675 Molecular Tunnel; other site 573061011676 short chain dehydrogenase; Provisional; Region: PRK06701 573061011677 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 573061011678 NAD binding site [chemical binding]; other site 573061011679 metal binding site [ion binding]; metal-binding site 573061011680 active site 573061011681 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 573061011682 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 573061011683 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 573061011684 Uncharacterized conserved protein [Function unknown]; Region: COG1434 573061011685 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573061011686 putative active site [active] 573061011687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061011688 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573061011689 NAD(P) binding site [chemical binding]; other site 573061011690 active site 573061011691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061011692 Zn2+ binding site [ion binding]; other site 573061011693 Mg2+ binding site [ion binding]; other site 573061011694 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573061011695 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 573061011696 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 573061011697 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573061011698 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 573061011699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573061011700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573061011701 active site 573061011702 catalytic tetrad [active] 573061011703 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061011704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061011705 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573061011706 Walker A/P-loop; other site 573061011707 ATP binding site [chemical binding]; other site 573061011708 Q-loop/lid; other site 573061011709 ABC transporter signature motif; other site 573061011710 Walker B; other site 573061011711 D-loop; other site 573061011712 H-loop/switch region; other site 573061011713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061011714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061011715 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573061011716 Walker A/P-loop; other site 573061011717 ATP binding site [chemical binding]; other site 573061011718 Q-loop/lid; other site 573061011719 ABC transporter signature motif; other site 573061011720 Walker B; other site 573061011721 D-loop; other site 573061011722 H-loop/switch region; other site 573061011723 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061011724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061011725 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061011726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061011727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061011728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061011729 dimer interface [polypeptide binding]; other site 573061011730 phosphorylation site [posttranslational modification] 573061011731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061011732 ATP binding site [chemical binding]; other site 573061011733 Mg2+ binding site [ion binding]; other site 573061011734 G-X-G motif; other site 573061011735 S-ribosylhomocysteinase; Provisional; Region: PRK02260 573061011736 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573061011737 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573061011738 Walker A/P-loop; other site 573061011739 ATP binding site [chemical binding]; other site 573061011740 Q-loop/lid; other site 573061011741 ABC transporter signature motif; other site 573061011742 Walker B; other site 573061011743 D-loop; other site 573061011744 H-loop/switch region; other site 573061011745 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573061011746 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573061011747 ABC-ATPase subunit interface; other site 573061011748 dimer interface [polypeptide binding]; other site 573061011749 putative PBP binding regions; other site 573061011750 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573061011751 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 573061011752 putative binding site residues; other site 573061011753 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 573061011754 homotrimer interface [polypeptide binding]; other site 573061011755 Walker A motif; other site 573061011756 GTP binding site [chemical binding]; other site 573061011757 Walker B motif; other site 573061011758 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573061011759 Ligand Binding Site [chemical binding]; other site 573061011760 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 573061011761 histidinol-phosphatase; Reviewed; Region: PRK08123 573061011762 active site 573061011763 dimer interface [polypeptide binding]; other site 573061011764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 573061011765 metal binding site [ion binding]; metal-binding site 573061011766 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 573061011767 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573061011768 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573061011769 substrate binding site [chemical binding]; other site 573061011770 glutamase interaction surface [polypeptide binding]; other site 573061011771 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573061011772 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 573061011773 catalytic residues [active] 573061011774 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 573061011775 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573061011776 putative active site [active] 573061011777 oxyanion strand; other site 573061011778 catalytic triad [active] 573061011779 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573061011780 putative active site pocket [active] 573061011781 4-fold oligomerization interface [polypeptide binding]; other site 573061011782 metal binding residues [ion binding]; metal-binding site 573061011783 3-fold/trimer interface [polypeptide binding]; other site 573061011784 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573061011785 histidinol dehydrogenase; Region: hisD; TIGR00069 573061011786 NAD binding site [chemical binding]; other site 573061011787 dimerization interface [polypeptide binding]; other site 573061011788 product binding site; other site 573061011789 substrate binding site [chemical binding]; other site 573061011790 zinc binding site [ion binding]; other site 573061011791 catalytic residues [active] 573061011792 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 573061011793 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 573061011794 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 573061011795 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573061011796 dimer interface [polypeptide binding]; other site 573061011797 motif 1; other site 573061011798 active site 573061011799 motif 2; other site 573061011800 motif 3; other site 573061011801 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061011802 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061011803 dimer interface [polypeptide binding]; other site 573061011804 putative CheW interface [polypeptide binding]; other site 573061011805 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 573061011806 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061011807 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573061011808 Condensation domain; Region: Condensation; pfam00668 573061011809 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 573061011810 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061011811 acyl-activating enzyme (AAE) consensus motif; other site 573061011812 AMP binding site [chemical binding]; other site 573061011813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011814 Condensation domain; Region: Condensation; pfam00668 573061011815 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011816 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011817 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 573061011818 acyl-activating enzyme (AAE) consensus motif; other site 573061011819 AMP binding site [chemical binding]; other site 573061011820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011821 Condensation domain; Region: Condensation; pfam00668 573061011822 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011823 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011824 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 573061011825 acyl-activating enzyme (AAE) consensus motif; other site 573061011826 AMP binding site [chemical binding]; other site 573061011827 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011828 thioester reductase domain; Region: Thioester-redct; TIGR01746 573061011829 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 573061011830 putative NAD(P) binding site [chemical binding]; other site 573061011831 active site 573061011832 putative substrate binding site [chemical binding]; other site 573061011833 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 573061011834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061011835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061011836 DNA binding residues [nucleotide binding] 573061011837 DNA topoisomerase III; Provisional; Region: PRK07726 573061011838 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 573061011839 active site 573061011840 putative interdomain interaction site [polypeptide binding]; other site 573061011841 putative metal-binding site [ion binding]; other site 573061011842 putative nucleotide binding site [chemical binding]; other site 573061011843 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573061011844 domain I; other site 573061011845 DNA binding groove [nucleotide binding] 573061011846 phosphate binding site [ion binding]; other site 573061011847 domain II; other site 573061011848 domain III; other site 573061011849 nucleotide binding site [chemical binding]; other site 573061011850 catalytic site [active] 573061011851 domain IV; other site 573061011852 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 573061011853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061011854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061011855 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 573061011856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573061011857 Beta-lactamase; Region: Beta-lactamase; pfam00144 573061011858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061011859 H+ Antiporter protein; Region: 2A0121; TIGR00900 573061011860 putative substrate translocation pore; other site 573061011861 Condensation domain; Region: Condensation; pfam00668 573061011862 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011863 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011864 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061011865 acyl-activating enzyme (AAE) consensus motif; other site 573061011866 AMP binding site [chemical binding]; other site 573061011867 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011868 Condensation domain; Region: Condensation; pfam00668 573061011869 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011870 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 573061011871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573061011872 Beta-lactamase; Region: Beta-lactamase; pfam00144 573061011873 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 573061011874 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 573061011875 active site 573061011876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011877 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573061011878 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573061011879 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011880 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 573061011881 acyl-activating enzyme (AAE) consensus motif; other site 573061011882 AMP binding site [chemical binding]; other site 573061011883 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011884 Condensation domain; Region: Condensation; pfam00668 573061011885 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011886 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011887 acyl-activating enzyme (AAE) consensus motif; other site 573061011888 AMP binding site [chemical binding]; other site 573061011889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011890 Condensation domain; Region: Condensation; pfam00668 573061011891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011892 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011893 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011894 acyl-activating enzyme (AAE) consensus motif; other site 573061011895 AMP binding site [chemical binding]; other site 573061011896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011897 Condensation domain; Region: Condensation; pfam00668 573061011898 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011899 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011900 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011901 acyl-activating enzyme (AAE) consensus motif; other site 573061011902 AMP binding site [chemical binding]; other site 573061011903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011904 Condensation domain; Region: Condensation; pfam00668 573061011905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011906 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011907 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 573061011908 acyl-activating enzyme (AAE) consensus motif; other site 573061011909 AMP binding site [chemical binding]; other site 573061011910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573061011911 Condensation domain; Region: Condensation; pfam00668 573061011912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 573061011913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 573061011914 FkbH-like domain; Region: FkbH; TIGR01686 573061011915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061011916 active site 573061011917 motif I; other site 573061011918 motif II; other site 573061011919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573061011920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573061011921 active site 573061011922 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 573061011923 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061011924 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061011925 catalytic residues [active] 573061011926 catalytic nucleophile [active] 573061011927 Recombinase; Region: Recombinase; pfam07508 573061011928 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 573061011929 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 573061011930 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 573061011931 G1 box; other site 573061011932 putative GEF interaction site [polypeptide binding]; other site 573061011933 GTP/Mg2+ binding site [chemical binding]; other site 573061011934 Switch I region; other site 573061011935 G2 box; other site 573061011936 G3 box; other site 573061011937 Switch II region; other site 573061011938 G4 box; other site 573061011939 G5 box; other site 573061011940 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 573061011941 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 573061011942 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 573061011943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061011944 DNA binding residues [nucleotide binding] 573061011945 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061011946 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061011947 catalytic residues [active] 573061011948 catalytic nucleophile [active] 573061011949 Recombinase; Region: Recombinase; pfam07508 573061011950 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061011951 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061011952 catalytic residues [active] 573061011953 catalytic nucleophile [active] 573061011954 Recombinase; Region: Recombinase; pfam07508 573061011955 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 573061011956 Helix-turn-helix domain; Region: HTH_38; pfam13936 573061011957 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573061011958 amidase catalytic site [active] 573061011959 Zn binding residues [ion binding]; other site 573061011960 substrate binding site [chemical binding]; other site 573061011961 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 573061011962 Bacterial SH3 domain; Region: SH3_3; pfam08239 573061011963 Holin family; Region: Phage_holin_4; pfam05105 573061011964 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573061011965 active site 573061011966 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061011967 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 573061011968 Phage tail protein; Region: Sipho_tail; pfam05709 573061011969 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 573061011970 linker region; other site 573061011971 Phage-related protein [Function unknown]; Region: COG5412 573061011972 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 573061011973 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 573061011974 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 573061011975 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 573061011976 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 573061011977 oligomerization interface [polypeptide binding]; other site 573061011978 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573061011979 Phage capsid family; Region: Phage_capsid; pfam05065 573061011980 Clp protease; Region: CLP_protease; pfam00574 573061011981 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 573061011982 oligomer interface [polypeptide binding]; other site 573061011983 active site residues [active] 573061011984 Phage-related protein [Function unknown]; Region: COG4695 573061011985 Phage portal protein; Region: Phage_portal; pfam04860 573061011986 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573061011987 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573061011988 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573061011989 putative active site pocket [active] 573061011990 dimerization interface [polypeptide binding]; other site 573061011991 putative catalytic residue [active] 573061011992 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 573061011993 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 573061011994 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061011995 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 573061011996 cofactor binding site; other site 573061011997 DNA binding site [nucleotide binding] 573061011998 substrate interaction site [chemical binding]; other site 573061011999 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061012000 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573061012001 ParB-like nuclease domain; Region: ParBc; pfam02195 573061012002 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573061012003 DNA methylase; Region: N6_N4_Mtase; pfam01555 573061012004 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573061012005 Phage terminase, small subunit; Region: Terminase_4; cl01525 573061012006 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573061012007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573061012008 active site 573061012009 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061012010 DNA binding residues [nucleotide binding] 573061012011 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 573061012012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573061012013 ATP binding site [chemical binding]; other site 573061012014 putative Mg++ binding site [ion binding]; other site 573061012015 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573061012016 VRR-NUC domain; Region: VRR_NUC; pfam08774 573061012017 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 573061012018 D5 N terminal like; Region: D5_N; pfam08706 573061012019 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573061012020 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 573061012021 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 573061012022 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 573061012023 active site 573061012024 DNA binding site [nucleotide binding] 573061012025 catalytic site [active] 573061012026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061012027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061012028 salt bridge; other site 573061012029 non-specific DNA binding site [nucleotide binding]; other site 573061012030 sequence-specific DNA binding site [nucleotide binding]; other site 573061012031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061012032 non-specific DNA binding site [nucleotide binding]; other site 573061012033 salt bridge; other site 573061012034 sequence-specific DNA binding site [nucleotide binding]; other site 573061012035 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 573061012036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573061012037 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 573061012038 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061012039 cofactor binding site; other site 573061012040 DNA binding site [nucleotide binding] 573061012041 substrate interaction site [chemical binding]; other site 573061012042 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061012043 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 573061012044 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573061012045 cofactor binding site; other site 573061012046 DNA binding site [nucleotide binding] 573061012047 substrate interaction site [chemical binding]; other site 573061012048 Helix-turn-helix domain; Region: HTH_17; pfam12728 573061012049 Penicillinase repressor; Region: Pencillinase_R; cl17580 573061012050 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 573061012051 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573061012052 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 573061012053 catalytic residues [active] 573061012054 catalytic nucleophile [active] 573061012055 Recombinase; Region: Recombinase; pfam07508 573061012056 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 573061012057 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573061012058 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 573061012059 active site 1 [active] 573061012060 dimer interface [polypeptide binding]; other site 573061012061 hexamer interface [polypeptide binding]; other site 573061012062 active site 2 [active] 573061012063 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 573061012064 active site 1 [active] 573061012065 dimer interface [polypeptide binding]; other site 573061012066 hexamer interface [polypeptide binding]; other site 573061012067 active site 2 [active] 573061012068 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 573061012069 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573061012070 putative N- and C-terminal domain interface [polypeptide binding]; other site 573061012071 putative active site [active] 573061012072 MgATP binding site [chemical binding]; other site 573061012073 catalytic site [active] 573061012074 metal binding site [ion binding]; metal-binding site 573061012075 putative carbohydrate binding site [chemical binding]; other site 573061012076 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573061012077 Domain of unknown function DUF21; Region: DUF21; pfam01595 573061012078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573061012079 Transporter associated domain; Region: CorC_HlyC; smart01091 573061012080 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573061012081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012082 active site 573061012083 phosphorylation site [posttranslational modification] 573061012084 intermolecular recognition site; other site 573061012085 CheB methylesterase; Region: CheB_methylest; pfam01339 573061012086 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573061012087 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573061012088 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573061012089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573061012090 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061012091 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061012092 dimer interface [polypeptide binding]; other site 573061012093 putative CheW interface [polypeptide binding]; other site 573061012094 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061012095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061012096 dimerization interface [polypeptide binding]; other site 573061012097 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573061012098 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573061012099 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573061012100 putative binding surface; other site 573061012101 active site 573061012102 P2 response regulator binding domain; Region: P2; pfam07194 573061012103 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573061012104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012105 ATP binding site [chemical binding]; other site 573061012106 Mg2+ binding site [ion binding]; other site 573061012107 G-X-G motif; other site 573061012108 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573061012109 Response regulator receiver domain; Region: Response_reg; pfam00072 573061012110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012111 active site 573061012112 phosphorylation site [posttranslational modification] 573061012113 intermolecular recognition site; other site 573061012114 dimerization interface [polypeptide binding]; other site 573061012115 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 573061012116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012117 Walker A/P-loop; other site 573061012118 ATP binding site [chemical binding]; other site 573061012119 Q-loop/lid; other site 573061012120 ABC transporter signature motif; other site 573061012121 Walker B; other site 573061012122 D-loop; other site 573061012123 H-loop/switch region; other site 573061012124 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 573061012125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012126 Walker A/P-loop; other site 573061012127 ATP binding site [chemical binding]; other site 573061012128 Q-loop/lid; other site 573061012129 ABC transporter signature motif; other site 573061012130 Walker B; other site 573061012131 D-loop; other site 573061012132 H-loop/switch region; other site 573061012133 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061012134 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 573061012135 TM-ABC transporter signature motif; other site 573061012136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573061012137 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 573061012138 zinc binding site [ion binding]; other site 573061012139 putative ligand binding site [chemical binding]; other site 573061012140 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573061012141 PAS domain; Region: PAS; smart00091 573061012142 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573061012143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061012144 dimer interface [polypeptide binding]; other site 573061012145 phosphorylation site [posttranslational modification] 573061012146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012147 ATP binding site [chemical binding]; other site 573061012148 Mg2+ binding site [ion binding]; other site 573061012149 G-X-G motif; other site 573061012150 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573061012151 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573061012152 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573061012153 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573061012154 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573061012155 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573061012156 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573061012157 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573061012158 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573061012159 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 573061012160 substrate binding site [chemical binding]; other site 573061012161 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573061012162 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 573061012163 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573061012164 catalytic site [active] 573061012165 subunit interface [polypeptide binding]; other site 573061012166 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573061012167 heterotetramer interface [polypeptide binding]; other site 573061012168 active site pocket [active] 573061012169 cleavage site 573061012170 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573061012171 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573061012172 acetylornithine aminotransferase; Provisional; Region: PRK02627 573061012173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573061012174 inhibitor-cofactor binding pocket; inhibition site 573061012175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061012176 catalytic residue [active] 573061012177 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 573061012178 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573061012179 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573061012180 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 573061012181 dinuclear metal binding motif [ion binding]; other site 573061012182 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 573061012183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012184 Walker A/P-loop; other site 573061012185 ATP binding site [chemical binding]; other site 573061012186 ABC transporter signature motif; other site 573061012187 Walker B; other site 573061012188 D-loop; other site 573061012189 H-loop/switch region; other site 573061012190 ABC transporter; Region: ABC_tran_2; pfam12848 573061012191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061012192 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573061012193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061012194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061012195 DNA binding site [nucleotide binding] 573061012196 domain linker motif; other site 573061012197 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573061012198 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061012199 putative metal binding site [ion binding]; other site 573061012200 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573061012201 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 573061012202 Predicted transcriptional regulator [Transcription]; Region: COG2932 573061012203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061012204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061012205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061012206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573061012207 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 573061012208 Part of AAA domain; Region: AAA_19; pfam13245 573061012209 Family description; Region: UvrD_C_2; pfam13538 573061012210 hypothetical protein; Reviewed; Region: PRK09588 573061012211 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 573061012212 Phosphotransferase enzyme family; Region: APH; pfam01636 573061012213 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 573061012214 active site 573061012215 substrate binding site [chemical binding]; other site 573061012216 ATP binding site [chemical binding]; other site 573061012217 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573061012218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061012219 Coenzyme A binding pocket [chemical binding]; other site 573061012220 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 573061012221 beta-galactosidase; Region: BGL; TIGR03356 573061012222 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061012223 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573061012224 Walker A/P-loop; other site 573061012225 ATP binding site [chemical binding]; other site 573061012226 Q-loop/lid; other site 573061012227 ABC transporter signature motif; other site 573061012228 Walker B; other site 573061012229 D-loop; other site 573061012230 H-loop/switch region; other site 573061012231 Response regulator receiver domain; Region: Response_reg; pfam00072 573061012232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012233 active site 573061012234 phosphorylation site [posttranslational modification] 573061012235 intermolecular recognition site; other site 573061012236 dimerization interface [polypeptide binding]; other site 573061012237 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573061012238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061012239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061012240 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573061012241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061012242 dimer interface [polypeptide binding]; other site 573061012243 conserved gate region; other site 573061012244 putative PBP binding loops; other site 573061012245 ABC-ATPase subunit interface; other site 573061012246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061012247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061012248 dimer interface [polypeptide binding]; other site 573061012249 conserved gate region; other site 573061012250 putative PBP binding loops; other site 573061012251 ABC-ATPase subunit interface; other site 573061012252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061012253 dimerization interface [polypeptide binding]; other site 573061012254 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573061012255 Histidine kinase; Region: His_kinase; pfam06580 573061012256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012257 ATP binding site [chemical binding]; other site 573061012258 Mg2+ binding site [ion binding]; other site 573061012259 G-X-G motif; other site 573061012260 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 573061012261 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573061012262 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573061012263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573061012264 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573061012265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061012266 active site 573061012267 motif I; other site 573061012268 motif II; other site 573061012269 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573061012270 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 573061012271 lipoprotein signal peptidase; Provisional; Region: PRK14787 573061012272 lipoprotein signal peptidase; Provisional; Region: PRK14791 573061012273 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573061012274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012275 Walker A/P-loop; other site 573061012276 ATP binding site [chemical binding]; other site 573061012277 Q-loop/lid; other site 573061012278 ABC transporter signature motif; other site 573061012279 Walker B; other site 573061012280 D-loop; other site 573061012281 H-loop/switch region; other site 573061012282 ABC transporter; Region: ABC_tran_2; pfam12848 573061012283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573061012284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573061012285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061012286 DNA binding site [nucleotide binding] 573061012287 domain linker motif; other site 573061012288 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 573061012289 putative ligand binding site [chemical binding]; other site 573061012290 putative dimerization interface [polypeptide binding]; other site 573061012291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573061012292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061012293 dimer interface [polypeptide binding]; other site 573061012294 conserved gate region; other site 573061012295 putative PBP binding loops; other site 573061012296 ABC-ATPase subunit interface; other site 573061012297 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573061012298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061012299 dimer interface [polypeptide binding]; other site 573061012300 conserved gate region; other site 573061012301 putative PBP binding loops; other site 573061012302 ABC-ATPase subunit interface; other site 573061012303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573061012304 dimerization interface [polypeptide binding]; other site 573061012305 Histidine kinase; Region: His_kinase; pfam06580 573061012306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012307 ATP binding site [chemical binding]; other site 573061012308 Mg2+ binding site [ion binding]; other site 573061012309 G-X-G motif; other site 573061012310 Response regulator receiver domain; Region: Response_reg; pfam00072 573061012311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012312 active site 573061012313 phosphorylation site [posttranslational modification] 573061012314 intermolecular recognition site; other site 573061012315 dimerization interface [polypeptide binding]; other site 573061012316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061012317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061012318 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 573061012319 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573061012320 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573061012321 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573061012322 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 573061012323 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 573061012324 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573061012325 active site 573061012326 catalytic site [active] 573061012327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061012328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061012329 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 573061012330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573061012331 DNA binding site [nucleotide binding] 573061012332 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 573061012333 putative dimerization interface [polypeptide binding]; other site 573061012334 putative ligand binding site [chemical binding]; other site 573061012335 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573061012336 active site 573061012337 catalytic residues [active] 573061012338 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 573061012339 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 573061012340 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 573061012341 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 573061012342 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573061012343 NAD binding site [chemical binding]; other site 573061012344 homodimer interface [polypeptide binding]; other site 573061012345 active site 573061012346 substrate binding site [chemical binding]; other site 573061012347 galactokinase; Provisional; Region: PRK05322 573061012348 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573061012349 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573061012350 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573061012351 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573061012352 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 573061012353 NodB motif; other site 573061012354 putative active site [active] 573061012355 putative catalytic site [active] 573061012356 putative Zn binding site [ion binding]; other site 573061012357 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573061012358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573061012359 catalytic loop [active] 573061012360 iron binding site [ion binding]; other site 573061012361 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 573061012362 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573061012363 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573061012364 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573061012365 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573061012366 synthetase active site [active] 573061012367 NTP binding site [chemical binding]; other site 573061012368 metal binding site [ion binding]; metal-binding site 573061012369 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573061012370 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573061012371 Walker A/P-loop; other site 573061012372 ATP binding site [chemical binding]; other site 573061012373 Q-loop/lid; other site 573061012374 ABC transporter signature motif; other site 573061012375 Walker B; other site 573061012376 D-loop; other site 573061012377 H-loop/switch region; other site 573061012378 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573061012379 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573061012380 Walker A/P-loop; other site 573061012381 ATP binding site [chemical binding]; other site 573061012382 Q-loop/lid; other site 573061012383 ABC transporter signature motif; other site 573061012384 Walker B; other site 573061012385 D-loop; other site 573061012386 H-loop/switch region; other site 573061012387 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 573061012388 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573061012389 TM-ABC transporter signature motif; other site 573061012390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573061012391 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573061012392 TM-ABC transporter signature motif; other site 573061012393 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573061012394 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 573061012395 putative ligand binding site [chemical binding]; other site 573061012396 Putative amidase domain; Region: Amidase_6; pfam12671 573061012397 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573061012398 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 573061012399 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573061012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 573061012401 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061012402 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061012403 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061012404 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061012405 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061012406 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061012407 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 573061012408 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061012409 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061012410 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 573061012411 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 573061012412 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 573061012413 active site 573061012414 catalytic residues [active] 573061012415 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573061012416 active site 573061012417 catalytic residues [active] 573061012418 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 573061012419 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 573061012420 active site 573061012421 catalytic triad [active] 573061012422 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573061012423 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573061012424 homodimer interface [polypeptide binding]; other site 573061012425 substrate-cofactor binding pocket; other site 573061012426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061012427 catalytic residue [active] 573061012428 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 573061012429 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573061012430 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 573061012431 active site 573061012432 putative catalytic site [active] 573061012433 DNA binding site [nucleotide binding] 573061012434 putative phosphate binding site [ion binding]; other site 573061012435 metal binding site A [ion binding]; metal-binding site 573061012436 AP binding site [nucleotide binding]; other site 573061012437 metal binding site B [ion binding]; metal-binding site 573061012438 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 573061012439 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_3; cd08975 573061012440 putative DNA binding site [nucleotide binding]; other site 573061012441 catalytic residue [active] 573061012442 putative H2TH interface [polypeptide binding]; other site 573061012443 putative catalytic residues [active] 573061012444 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573061012445 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573061012446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573061012447 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061012448 putative metal binding site [ion binding]; other site 573061012449 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 573061012450 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061012451 putative metal binding site [ion binding]; other site 573061012452 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061012453 putative metal binding site [ion binding]; other site 573061012454 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 573061012455 putative metal binding site [ion binding]; other site 573061012456 Dockerin type I repeat; Region: Dockerin_1; pfam00404 573061012457 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 573061012458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061012459 FeS/SAM binding site; other site 573061012460 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061012461 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573061012462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061012463 binding surface 573061012464 TPR motif; other site 573061012465 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 573061012466 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 573061012467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061012468 FeS/SAM binding site; other site 573061012469 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573061012470 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573061012471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573061012472 binding surface 573061012473 TPR motif; other site 573061012474 FtsX-like permease family; Region: FtsX; pfam02687 573061012475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061012476 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061012477 FtsX-like permease family; Region: FtsX; pfam02687 573061012478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061012479 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061012480 Walker A/P-loop; other site 573061012481 ATP binding site [chemical binding]; other site 573061012482 Q-loop/lid; other site 573061012483 ABC transporter signature motif; other site 573061012484 Walker B; other site 573061012485 D-loop; other site 573061012486 H-loop/switch region; other site 573061012487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061012488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061012489 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 573061012490 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 573061012491 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573061012492 biotin carboxylase; Validated; Region: PRK05586 573061012493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573061012494 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573061012495 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573061012496 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573061012497 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 573061012498 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573061012499 carboxyltransferase (CT) interaction site; other site 573061012500 biotinylation site [posttranslational modification]; other site 573061012501 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 573061012502 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573061012503 dimer interface [polypeptide binding]; other site 573061012504 active site 573061012505 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573061012506 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573061012507 NAD(P) binding site [chemical binding]; other site 573061012508 homotetramer interface [polypeptide binding]; other site 573061012509 homodimer interface [polypeptide binding]; other site 573061012510 active site 573061012511 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573061012512 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573061012513 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 573061012514 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 573061012515 FMN binding site [chemical binding]; other site 573061012516 substrate binding site [chemical binding]; other site 573061012517 putative catalytic residue [active] 573061012518 acyl carrier protein; Provisional; Region: acpP; PRK00982 573061012519 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573061012520 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573061012521 dimer interface [polypeptide binding]; other site 573061012522 active site 573061012523 CoA binding pocket [chemical binding]; other site 573061012524 MarR family; Region: MarR_2; pfam12802 573061012525 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573061012526 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573061012527 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 573061012528 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 573061012529 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 573061012530 FMN binding site [chemical binding]; other site 573061012531 substrate binding site [chemical binding]; other site 573061012532 putative catalytic residue [active] 573061012533 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 573061012534 putative FMN binding site [chemical binding]; other site 573061012535 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 573061012536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573061012537 putative active site [active] 573061012538 putative metal binding site [ion binding]; other site 573061012539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012540 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061012541 Walker A/P-loop; other site 573061012542 ATP binding site [chemical binding]; other site 573061012543 Q-loop/lid; other site 573061012544 ABC transporter signature motif; other site 573061012545 Walker B; other site 573061012546 D-loop; other site 573061012547 H-loop/switch region; other site 573061012548 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573061012549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573061012550 dimer interface [polypeptide binding]; other site 573061012551 conserved gate region; other site 573061012552 putative PBP binding loops; other site 573061012553 ABC-ATPase subunit interface; other site 573061012554 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573061012555 Rubrerythrin [Energy production and conversion]; Region: COG1592 573061012556 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573061012557 binuclear metal center [ion binding]; other site 573061012558 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573061012559 iron binding site [ion binding]; other site 573061012560 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 573061012561 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 573061012562 non-heme iron binding site [ion binding]; other site 573061012563 dimer interface [polypeptide binding]; other site 573061012564 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 573061012565 non-heme iron binding site [ion binding]; other site 573061012566 dimer interface [polypeptide binding]; other site 573061012567 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 573061012568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061012569 Coenzyme A binding pocket [chemical binding]; other site 573061012570 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 573061012571 DNA binding residues [nucleotide binding] 573061012572 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573061012573 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 573061012574 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573061012575 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573061012576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573061012577 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573061012578 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573061012579 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573061012580 Pleckstrin homology-like domain; Region: PH-like; cl17171 573061012581 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 573061012582 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573061012583 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573061012584 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 573061012585 nucleophilic elbow; other site 573061012586 catalytic triad; other site 573061012587 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 573061012588 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573061012589 dimer interface [polypeptide binding]; other site 573061012590 active site 573061012591 CoA binding pocket [chemical binding]; other site 573061012592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573061012593 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 573061012594 acyl-activating enzyme (AAE) consensus motif; other site 573061012595 AMP binding site [chemical binding]; other site 573061012596 active site 573061012597 CoA binding site [chemical binding]; other site 573061012598 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061012599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061012600 dimer interface [polypeptide binding]; other site 573061012601 putative CheW interface [polypeptide binding]; other site 573061012602 FtsX-like permease family; Region: FtsX; pfam02687 573061012603 FtsX-like permease family; Region: FtsX; pfam02687 573061012604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061012605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061012606 Walker A/P-loop; other site 573061012607 ATP binding site [chemical binding]; other site 573061012608 Q-loop/lid; other site 573061012609 ABC transporter signature motif; other site 573061012610 Walker B; other site 573061012611 D-loop; other site 573061012612 H-loop/switch region; other site 573061012613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061012614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061012615 dimer interface [polypeptide binding]; other site 573061012616 phosphorylation site [posttranslational modification] 573061012617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012618 ATP binding site [chemical binding]; other site 573061012619 Mg2+ binding site [ion binding]; other site 573061012620 G-X-G motif; other site 573061012621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061012622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012623 active site 573061012624 phosphorylation site [posttranslational modification] 573061012625 intermolecular recognition site; other site 573061012626 dimerization interface [polypeptide binding]; other site 573061012627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061012628 DNA binding site [nucleotide binding] 573061012629 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573061012630 putative FMN binding site [chemical binding]; other site 573061012631 NADPH bind site [chemical binding]; other site 573061012632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061012633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061012634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061012635 putative substrate translocation pore; other site 573061012636 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573061012637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061012638 putative substrate translocation pore; other site 573061012639 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573061012640 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573061012641 putative valine binding site [chemical binding]; other site 573061012642 dimer interface [polypeptide binding]; other site 573061012643 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573061012644 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 573061012645 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573061012646 PYR/PP interface [polypeptide binding]; other site 573061012647 dimer interface [polypeptide binding]; other site 573061012648 TPP binding site [chemical binding]; other site 573061012649 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573061012650 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573061012651 TPP-binding site [chemical binding]; other site 573061012652 dimer interface [polypeptide binding]; other site 573061012653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573061012654 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061012655 FtsX-like permease family; Region: FtsX; pfam02687 573061012656 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061012657 FtsX-like permease family; Region: FtsX; pfam02687 573061012658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061012659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061012660 Walker A/P-loop; other site 573061012661 ATP binding site [chemical binding]; other site 573061012662 Q-loop/lid; other site 573061012663 ABC transporter signature motif; other site 573061012664 Walker B; other site 573061012665 D-loop; other site 573061012666 H-loop/switch region; other site 573061012667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061012668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061012669 dimer interface [polypeptide binding]; other site 573061012670 phosphorylation site [posttranslational modification] 573061012671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012672 ATP binding site [chemical binding]; other site 573061012673 Mg2+ binding site [ion binding]; other site 573061012674 G-X-G motif; other site 573061012675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061012676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012677 active site 573061012678 phosphorylation site [posttranslational modification] 573061012679 intermolecular recognition site; other site 573061012680 dimerization interface [polypeptide binding]; other site 573061012681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061012682 DNA binding site [nucleotide binding] 573061012683 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573061012684 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573061012685 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573061012686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061012687 dimer interface [polypeptide binding]; other site 573061012688 putative CheW interface [polypeptide binding]; other site 573061012689 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061012690 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573061012691 nucleophilic elbow; other site 573061012692 catalytic triad; other site 573061012693 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 573061012694 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 573061012695 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 573061012696 putative catalytic cysteine [active] 573061012697 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 573061012698 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 573061012699 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 573061012700 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 573061012701 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573061012702 dimer interface [polypeptide binding]; other site 573061012703 PYR/PP interface [polypeptide binding]; other site 573061012704 TPP binding site [chemical binding]; other site 573061012705 substrate binding site [chemical binding]; other site 573061012706 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 573061012707 TPP-binding site; other site 573061012708 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573061012709 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 573061012710 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573061012711 conserved cys residue [active] 573061012712 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573061012713 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 573061012714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573061012715 FeS/SAM binding site; other site 573061012716 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 573061012717 active site 573061012718 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061012719 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061012720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573061012721 dimer interface [polypeptide binding]; other site 573061012722 putative CheW interface [polypeptide binding]; other site 573061012723 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573061012724 glycosyltransferase, MGT family; Region: MGT; TIGR01426 573061012725 active site 573061012726 TDP-binding site; other site 573061012727 acceptor substrate-binding pocket; other site 573061012728 homodimer interface [polypeptide binding]; other site 573061012729 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061012730 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061012731 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573061012732 FMN binding site [chemical binding]; other site 573061012733 dimer interface [polypeptide binding]; other site 573061012734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573061012735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573061012736 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 573061012737 putative dimerization interface [polypeptide binding]; other site 573061012738 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573061012739 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573061012740 active site 573061012741 NAD binding site [chemical binding]; other site 573061012742 metal binding site [ion binding]; metal-binding site 573061012743 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 573061012744 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 573061012745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573061012746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573061012747 DNA binding residues [nucleotide binding] 573061012748 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573061012749 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573061012750 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573061012751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061012752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573061012753 dimer interface [polypeptide binding]; other site 573061012754 phosphorylation site [posttranslational modification] 573061012755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061012756 ATP binding site [chemical binding]; other site 573061012757 Mg2+ binding site [ion binding]; other site 573061012758 G-X-G motif; other site 573061012759 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 573061012760 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 573061012761 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061012762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012763 Walker A/P-loop; other site 573061012764 ATP binding site [chemical binding]; other site 573061012765 Q-loop/lid; other site 573061012766 ABC transporter signature motif; other site 573061012767 Walker B; other site 573061012768 D-loop; other site 573061012769 H-loop/switch region; other site 573061012770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061012772 active site 573061012773 phosphorylation site [posttranslational modification] 573061012774 intermolecular recognition site; other site 573061012775 dimerization interface [polypeptide binding]; other site 573061012776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061012777 DNA binding site [nucleotide binding] 573061012778 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 573061012779 active site 573061012780 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 573061012781 RNAase interaction site [polypeptide binding]; other site 573061012782 EamA-like transporter family; Region: EamA; cl17759 573061012783 Homeodomain-like domain; Region: HTH_23; cl17451 573061012784 putative transposase OrfB; Reviewed; Region: PHA02517 573061012785 HTH-like domain; Region: HTH_21; pfam13276 573061012786 Integrase core domain; Region: rve; pfam00665 573061012787 Integrase core domain; Region: rve_3; pfam13683 573061012788 SdpI/YhfL protein family; Region: SdpI; pfam13630 573061012789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573061012790 putative substrate translocation pore; other site 573061012791 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573061012792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061012793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573061012794 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573061012795 catalytic residues [active] 573061012796 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 573061012797 catalytic residues [active] 573061012798 dimer interface [polypeptide binding]; other site 573061012799 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 573061012800 catalytic residues [active] 573061012801 dimer interface [polypeptide binding]; other site 573061012802 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573061012803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573061012804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061012805 homodimer interface [polypeptide binding]; other site 573061012806 catalytic residue [active] 573061012807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573061012808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012809 Walker A/P-loop; other site 573061012810 ATP binding site [chemical binding]; other site 573061012811 Q-loop/lid; other site 573061012812 ABC transporter signature motif; other site 573061012813 Walker B; other site 573061012814 D-loop; other site 573061012815 H-loop/switch region; other site 573061012816 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 573061012817 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061012818 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573061012819 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061012820 Peptidase C39 family; Region: Peptidase_C39; pfam03412 573061012821 putative active site [active] 573061012822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061012823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012824 Walker A/P-loop; other site 573061012825 ATP binding site [chemical binding]; other site 573061012826 Q-loop/lid; other site 573061012827 ABC transporter signature motif; other site 573061012828 Walker B; other site 573061012829 D-loop; other site 573061012830 H-loop/switch region; other site 573061012831 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 573061012832 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061012833 active site 573061012834 zinc binding site [ion binding]; other site 573061012835 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 573061012836 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061012837 putative active site [active] 573061012838 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061012839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012840 Walker A/P-loop; other site 573061012841 ATP binding site [chemical binding]; other site 573061012842 Q-loop/lid; other site 573061012843 ABC transporter signature motif; other site 573061012844 Walker B; other site 573061012845 D-loop; other site 573061012846 H-loop/switch region; other site 573061012847 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 573061012848 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061012849 active site 573061012850 zinc binding site [ion binding]; other site 573061012851 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573061012852 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573061012853 active site 573061012854 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573061012855 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 573061012856 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061012857 ACS interaction site; other site 573061012858 CODH interaction site; other site 573061012859 metal cluster binding site [ion binding]; other site 573061012860 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 573061012861 Predicted transcriptional regulators [Transcription]; Region: COG1695 573061012862 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573061012863 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573061012864 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573061012865 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 573061012866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573061012867 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061012868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012869 Walker A/P-loop; other site 573061012870 ATP binding site [chemical binding]; other site 573061012871 Q-loop/lid; other site 573061012872 ABC transporter signature motif; other site 573061012873 Walker B; other site 573061012874 D-loop; other site 573061012875 H-loop/switch region; other site 573061012876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573061012877 dimerization interface [polypeptide binding]; other site 573061012878 putative DNA binding site [nucleotide binding]; other site 573061012879 putative Zn2+ binding site [ion binding]; other site 573061012880 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 573061012881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061012882 Coenzyme A binding pocket [chemical binding]; other site 573061012883 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061012884 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061012885 Uncharacterized conserved protein [Function unknown]; Region: COG1262 573061012886 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 573061012887 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573061012888 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061012889 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061012890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573061012891 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 573061012892 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 573061012893 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573061012894 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 573061012895 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 573061012896 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 573061012897 putative DNA binding site [nucleotide binding]; other site 573061012898 putative Zn2+ binding site [ion binding]; other site 573061012899 AsnC family; Region: AsnC_trans_reg; pfam01037 573061012900 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573061012901 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573061012902 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061012903 DNA binding residues [nucleotide binding] 573061012904 dimer interface [polypeptide binding]; other site 573061012905 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573061012906 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061012907 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061012908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012909 active site 573061012910 phosphorylation site [posttranslational modification] 573061012911 intermolecular recognition site; other site 573061012912 dimerization interface [polypeptide binding]; other site 573061012913 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061012914 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573061012915 putative accessory gene regulator protein; Provisional; Region: PRK01100 573061012916 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061012917 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 573061012918 active site 573061012919 zinc binding site [ion binding]; other site 573061012920 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 573061012921 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 573061012922 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 573061012923 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573061012924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061012925 active site 573061012926 phosphorylation site [posttranslational modification] 573061012927 intermolecular recognition site; other site 573061012928 dimerization interface [polypeptide binding]; other site 573061012929 LytTr DNA-binding domain; Region: LytTR; pfam04397 573061012930 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573061012931 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573061012932 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573061012933 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 573061012934 putative active site [active] 573061012935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573061012936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573061012937 Walker A/P-loop; other site 573061012938 ATP binding site [chemical binding]; other site 573061012939 Q-loop/lid; other site 573061012940 ABC transporter signature motif; other site 573061012941 Walker B; other site 573061012942 D-loop; other site 573061012943 H-loop/switch region; other site 573061012944 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 573061012945 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573061012946 active site 573061012947 zinc binding site [ion binding]; other site 573061012948 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061012949 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 573061012950 Predicted transcriptional regulator [Transcription]; Region: COG2378 573061012951 HTH domain; Region: HTH_11; pfam08279 573061012952 WYL domain; Region: WYL; pfam13280 573061012953 Protein of unknown function DUF116; Region: DUF116; pfam01976 573061012954 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 573061012955 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 573061012956 Ligand Binding Site [chemical binding]; other site 573061012957 hypothetical protein; Provisional; Region: PRK04194 573061012958 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573061012959 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573061012960 Walker A/P-loop; other site 573061012961 ATP binding site [chemical binding]; other site 573061012962 Q-loop/lid; other site 573061012963 ABC transporter signature motif; other site 573061012964 Walker B; other site 573061012965 D-loop; other site 573061012966 H-loop/switch region; other site 573061012967 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573061012968 cobalt transport protein CbiM; Provisional; Region: PRK07331 573061012969 cobalt transport protein CbiM; Provisional; Region: PRK11909 573061012970 PDGLE domain; Region: PDGLE; pfam13190 573061012971 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573061012972 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573061012973 active site 573061012974 catalytic tetrad [active] 573061012975 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573061012976 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 573061012977 trehalose synthase; Region: treS_nterm; TIGR02456 573061012978 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 573061012979 active site 573061012980 catalytic site [active] 573061012981 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573061012982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061012983 Zn2+ binding site [ion binding]; other site 573061012984 Mg2+ binding site [ion binding]; other site 573061012985 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061012986 Zn2+ binding site [ion binding]; other site 573061012987 Mg2+ binding site [ion binding]; other site 573061012988 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 573061012989 Mor transcription activator family; Region: Mor; cl02360 573061012990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573061012991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573061012992 Endonuclease I; Region: Endonuclease_1; pfam04231 573061012993 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 573061012994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573061012995 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 573061012996 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 573061012997 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 573061012998 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573061012999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061013000 catalytic residue [active] 573061013001 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573061013002 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 573061013003 putative substrate binding site [chemical binding]; other site 573061013004 putative ATP binding site [chemical binding]; other site 573061013005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061013006 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573061013007 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 573061013008 nucleotide binding site [chemical binding]; other site 573061013009 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 573061013010 nucleotide binding site [chemical binding]; other site 573061013011 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573061013012 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573061013013 DNA binding residues [nucleotide binding] 573061013014 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 573061013015 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 573061013016 fructuronate transporter; Provisional; Region: PRK10034; cl15264 573061013017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573061013018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573061013019 salt bridge; other site 573061013020 non-specific DNA binding site [nucleotide binding]; other site 573061013021 sequence-specific DNA binding site [nucleotide binding]; other site 573061013022 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 573061013023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573061013024 motif II; other site 573061013025 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573061013026 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573061013027 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573061013028 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573061013029 inhibitor-cofactor binding pocket; inhibition site 573061013030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573061013031 catalytic residue [active] 573061013032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573061013033 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573061013034 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573061013035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061013036 Walker A motif; other site 573061013037 ATP binding site [chemical binding]; other site 573061013038 Walker B motif; other site 573061013039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 573061013040 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 573061013041 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573061013042 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573061013043 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 573061013044 oligomer interface [polypeptide binding]; other site 573061013045 metal binding site [ion binding]; metal-binding site 573061013046 metal binding site [ion binding]; metal-binding site 573061013047 putative Cl binding site [ion binding]; other site 573061013048 aspartate ring; other site 573061013049 basic sphincter; other site 573061013050 hydrophobic gate; other site 573061013051 periplasmic entrance; other site 573061013052 LytTr DNA-binding domain; Region: LytTR; smart00850 573061013053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573061013054 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573061013055 NAD(P) binding site [chemical binding]; other site 573061013056 active site 573061013057 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 573061013058 active site 573061013059 catalytic site [active] 573061013060 substrate binding site [chemical binding]; other site 573061013061 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573061013062 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573061013063 putative catalytic cysteine [active] 573061013064 Predicted membrane protein [Function unknown]; Region: COG2364 573061013065 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573061013066 phosphopentomutase; Provisional; Region: PRK05362 573061013067 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 573061013068 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573061013069 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573061013070 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573061013071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573061013072 DNA-binding site [nucleotide binding]; DNA binding site 573061013073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061013074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061013075 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573061013076 Phosphotransferase enzyme family; Region: APH; pfam01636 573061013077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573061013078 active site 573061013079 ATP binding site [chemical binding]; other site 573061013080 Predicted membrane protein [Function unknown]; Region: COG2364 573061013081 FtsX-like permease family; Region: FtsX; pfam02687 573061013082 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573061013083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573061013084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573061013085 Walker A/P-loop; other site 573061013086 ATP binding site [chemical binding]; other site 573061013087 Q-loop/lid; other site 573061013088 ABC transporter signature motif; other site 573061013089 Walker B; other site 573061013090 D-loop; other site 573061013091 H-loop/switch region; other site 573061013092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573061013093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573061013094 phosphorylation site [posttranslational modification] 573061013095 dimer interface [polypeptide binding]; other site 573061013096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573061013097 ATP binding site [chemical binding]; other site 573061013098 Mg2+ binding site [ion binding]; other site 573061013099 G-X-G motif; other site 573061013100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573061013101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573061013102 active site 573061013103 phosphorylation site [posttranslational modification] 573061013104 intermolecular recognition site; other site 573061013105 dimerization interface [polypeptide binding]; other site 573061013106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573061013107 DNA binding site [nucleotide binding] 573061013108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573061013109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573061013110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573061013111 Coenzyme A binding pocket [chemical binding]; other site 573061013112 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573061013113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573061013114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573061013115 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573061013116 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 573061013117 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573061013118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061013119 S-adenosylmethionine binding site [chemical binding]; other site 573061013120 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 573061013121 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 573061013122 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573061013123 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 573061013124 active site 573061013125 purine riboside binding site [chemical binding]; other site 573061013126 hypothetical protein; Provisional; Region: PRK05590 573061013127 Sporulation and spore germination; Region: Germane; smart00909 573061013128 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 573061013129 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573061013130 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573061013131 active site 573061013132 hinge; other site 573061013133 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 573061013134 active site 573061013135 homodimer interface [polypeptide binding]; other site 573061013136 metal binding site [ion binding]; metal-binding site 573061013137 Protein of unknown function, DUF606; Region: DUF606; pfam04657 573061013138 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573061013139 active site 573061013140 catalytic residues [active] 573061013141 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 573061013142 DNA topoisomerase III; Provisional; Region: PRK07726 573061013143 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 573061013144 active site 573061013145 putative interdomain interaction site [polypeptide binding]; other site 573061013146 putative metal-binding site [ion binding]; other site 573061013147 putative nucleotide binding site [chemical binding]; other site 573061013148 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573061013149 domain I; other site 573061013150 DNA binding groove [nucleotide binding] 573061013151 phosphate binding site [ion binding]; other site 573061013152 domain II; other site 573061013153 domain III; other site 573061013154 nucleotide binding site [chemical binding]; other site 573061013155 catalytic site [active] 573061013156 domain IV; other site 573061013157 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 573061013158 competence damage-inducible protein A; Provisional; Region: PRK00549 573061013159 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 573061013160 putative MPT binding site; other site 573061013161 Competence-damaged protein; Region: CinA; pfam02464 573061013162 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 573061013163 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 573061013164 DNA replication protein DnaC; Validated; Region: PRK06835 573061013165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061013166 Walker A motif; other site 573061013167 ATP binding site [chemical binding]; other site 573061013168 PEP synthetase regulatory protein; Provisional; Region: PRK05339 573061013169 CoA binding domain; Region: CoA_binding_2; pfam13380 573061013170 flavoprotein, HI0933 family; Region: TIGR00275 573061013171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573061013172 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 573061013173 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573061013174 active site 573061013175 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573061013176 active site 573061013177 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 573061013178 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573061013179 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573061013180 GDP-binding site [chemical binding]; other site 573061013181 ACT binding site; other site 573061013182 IMP binding site; other site 573061013183 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573061013184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061013185 Zn2+ binding site [ion binding]; other site 573061013186 Mg2+ binding site [ion binding]; other site 573061013187 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 573061013188 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573061013189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573061013190 Zn2+ binding site [ion binding]; other site 573061013191 Mg2+ binding site [ion binding]; other site 573061013192 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573061013193 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573061013194 active site 573061013195 catalytic site [active] 573061013196 substrate binding site [chemical binding]; other site 573061013197 replicative DNA helicase; Provisional; Region: PRK05595 573061013198 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573061013199 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573061013200 Walker A motif; other site 573061013201 ATP binding site [chemical binding]; other site 573061013202 Walker B motif; other site 573061013203 DNA binding loops [nucleotide binding] 573061013204 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 573061013205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573061013206 Walker A motif; other site 573061013207 ATP binding site [chemical binding]; other site 573061013208 Walker B motif; other site 573061013209 arginine finger; other site 573061013210 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573061013211 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573061013212 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573061013213 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573061013214 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 573061013215 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 573061013216 DHH family; Region: DHH; pfam01368 573061013217 DHHA1 domain; Region: DHHA1; pfam02272 573061013218 MazG-like family; Region: MazG-like; pfam12643 573061013219 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573061013220 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573061013221 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573061013222 dimer interface [polypeptide binding]; other site 573061013223 ssDNA binding site [nucleotide binding]; other site 573061013224 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573061013225 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573061013226 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 573061013227 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573061013228 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573061013229 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 573061013230 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573061013231 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573061013232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573061013233 catalytic residue [active] 573061013234 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 573061013235 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 573061013236 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 573061013237 ParB-like nuclease domain; Region: ParB; smart00470 573061013238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573061013239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573061013240 P-loop; other site 573061013241 Magnesium ion binding site [ion binding]; other site 573061013242 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573061013243 Magnesium ion binding site [ion binding]; other site 573061013244 ParB-like nuclease domain; Region: ParBc; pfam02195 573061013245 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 573061013246 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 573061013247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573061013248 S-adenosylmethionine binding site [chemical binding]; other site 573061013249 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573061013250 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573061013251 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573061013252 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573061013253 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573061013254 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573061013255 G1 box; other site 573061013256 GTP/Mg2+ binding site [chemical binding]; other site 573061013257 Switch I region; other site 573061013258 G2 box; other site 573061013259 Switch II region; other site 573061013260 G3 box; other site 573061013261 G4 box; other site 573061013262 G5 box; other site 573061013263 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573061013264 Predicted transcriptional regulators [Transcription]; Region: COG1733 573061013265 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573061013266 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 573061013267 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 573061013268 G-X-X-G motif; other site 573061013269 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 573061013270 RxxxH motif; other site 573061013271 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 573061013272 Haemolytic domain; Region: Haemolytic; pfam01809 573061013273 ribonuclease P; Reviewed; Region: rnpA; PRK00499 573061013274 Ribosomal protein L34; Region: Ribosomal_L34; cl00370