-- dump date   	20140619_043917
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
717608000001	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
717608000002	HIT family signature motif; other site
717608000003	catalytic residue [active]
717608000004	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717608000005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608000006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608000007	DNA binding residues [nucleotide binding]
717608000008	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
717608000009	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
717608000010	active site
717608000011	homodimer interface [polypeptide binding]; other site
717608000012	TSCPD domain; Region: TSCPD; cl14834
717608000013	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
717608000014	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
717608000015	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
717608000016	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
717608000017	active site
717608000018	dimer interface [polypeptide binding]; other site
717608000019	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
717608000020	dimer interface [polypeptide binding]; other site
717608000021	active site
717608000022	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
717608000023	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
717608000024	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
717608000025	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
717608000026	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
717608000027	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717608000028	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
717608000029	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
717608000030	TPP-binding site [chemical binding]; other site
717608000031	dimer interface [polypeptide binding]; other site
717608000032	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
717608000033	PYR/PP interface [polypeptide binding]; other site
717608000034	dimer interface [polypeptide binding]; other site
717608000035	TPP binding site [chemical binding]; other site
717608000036	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
717608000037	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
717608000038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717608000039	nucleotide binding site [chemical binding]; other site
717608000040	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
717608000041	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
717608000042	DRTGG domain; Region: DRTGG; pfam07085
717608000043	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
717608000044	DHHA2 domain; Region: DHHA2; pfam02833
717608000045	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
717608000046	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
717608000047	Shikimate kinase; Region: SKI; pfam01202
717608000048	ADP binding site [chemical binding]; other site
717608000049	magnesium binding site [ion binding]; other site
717608000050	putative shikimate binding site; other site
717608000051	DNA topoisomerase III; Provisional; Region: PRK07726
717608000052	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717608000053	active site
717608000054	putative interdomain interaction site [polypeptide binding]; other site
717608000055	putative metal-binding site [ion binding]; other site
717608000056	putative nucleotide binding site [chemical binding]; other site
717608000057	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717608000058	domain I; other site
717608000059	DNA binding groove [nucleotide binding]
717608000060	phosphate binding site [ion binding]; other site
717608000061	domain II; other site
717608000062	domain III; other site
717608000063	nucleotide binding site [chemical binding]; other site
717608000064	catalytic site [active]
717608000065	domain IV; other site
717608000066	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
717608000067	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
717608000068	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
717608000069	dimer interface [polypeptide binding]; other site
717608000070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608000071	catalytic residue [active]
717608000072	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
717608000073	Predicted transcriptional regulators [Transcription]; Region: COG1695
717608000074	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
717608000075	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717608000076	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
717608000077	Ligand binding site; other site
717608000078	Putative Catalytic site; other site
717608000079	DXD motif; other site
717608000080	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
717608000081	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
717608000082	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
717608000083	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
717608000084	YcxB-like protein; Region: YcxB; pfam14317
717608000085	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
717608000086	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
717608000087	Propionate catabolism activator; Region: PrpR_N; pfam06506
717608000088	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717608000089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000090	Walker A motif; other site
717608000091	ATP binding site [chemical binding]; other site
717608000092	Walker B motif; other site
717608000093	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717608000094	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
717608000095	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
717608000096	ligand binding site [chemical binding]; other site
717608000097	NAD binding site [chemical binding]; other site
717608000098	dimerization interface [polypeptide binding]; other site
717608000099	catalytic site [active]
717608000100	hypothetical protein; Validated; Region: PRK06201
717608000101	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
717608000102	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
717608000103	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
717608000104	transmembrane helices; other site
717608000105	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
717608000106	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608000107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608000108	active site
717608000109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608000110	DNA-binding site [nucleotide binding]; DNA binding site
717608000111	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
717608000112	UTRA domain; Region: UTRA; pfam07702
717608000113	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
717608000114	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
717608000115	active site turn [active]
717608000116	phosphorylation site [posttranslational modification]
717608000117	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717608000118	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
717608000119	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
717608000120	Ca binding site [ion binding]; other site
717608000121	active site
717608000122	catalytic site [active]
717608000123	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
717608000124	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
717608000125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608000126	active site
717608000127	motif I; other site
717608000128	motif II; other site
717608000129	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608000130	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608000131	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
717608000132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608000133	dimer interface [polypeptide binding]; other site
717608000134	conserved gate region; other site
717608000135	putative PBP binding loops; other site
717608000136	ABC-ATPase subunit interface; other site
717608000137	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717608000138	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717608000139	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
717608000140	active site
717608000141	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
717608000142	Domain of unknown function (DUF368); Region: DUF368; pfam04018
717608000143	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
717608000144	catalytic residues [active]
717608000145	catalytic nucleophile [active]
717608000146	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608000147	Transposase domain (DUF772); Region: DUF772; pfam05598
717608000148	QueT transporter; Region: QueT; pfam06177
717608000149	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
717608000150	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717608000151	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717608000152	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717608000153	DNA replication protein DnaC; Validated; Region: PRK06835
717608000154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000155	Walker A motif; other site
717608000156	ATP binding site [chemical binding]; other site
717608000157	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
717608000158	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
717608000159	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608000160	active site
717608000161	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
717608000162	Formaldehyde dehydrogenases; Region: FDH_like; cd05278
717608000163	catalytic Zn binding site [ion binding]; other site
717608000164	NAD(P) binding site [chemical binding]; other site
717608000165	structural Zn binding site [ion binding]; other site
717608000166	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
717608000167	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
717608000168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000169	AAA domain; Region: AAA_23; pfam13476
717608000170	Walker A/P-loop; other site
717608000171	ATP binding site [chemical binding]; other site
717608000172	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
717608000173	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
717608000174	putative dimer interface [polypeptide binding]; other site
717608000175	putative anticodon binding site; other site
717608000176	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
717608000177	homodimer interface [polypeptide binding]; other site
717608000178	motif 1; other site
717608000179	motif 2; other site
717608000180	active site
717608000181	motif 3; other site
717608000182	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
717608000183	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
717608000184	ligand binding site; other site
717608000185	oligomer interface; other site
717608000186	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
717608000187	dimer interface [polypeptide binding]; other site
717608000188	N-terminal domain interface [polypeptide binding]; other site
717608000189	sulfate 1 binding site; other site
717608000190	regulatory protein SpoVG; Reviewed; Region: PRK13259
717608000191	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
717608000192	stage V sporulation protein T; Region: spore_V_T; TIGR02851
717608000193	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
717608000194	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
717608000195	IHF dimer interface [polypeptide binding]; other site
717608000196	IHF - DNA interface [nucleotide binding]; other site
717608000197	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608000198	RNA binding surface [nucleotide binding]; other site
717608000199	YabP family; Region: YabP; cl06766
717608000200	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
717608000201	stage II sporulation protein E; Region: spore_II_E; TIGR02865
717608000202	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
717608000203	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
717608000204	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
717608000205	Ligand Binding Site [chemical binding]; other site
717608000206	TilS substrate C-terminal domain; Region: TilS_C; smart00977
717608000207	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
717608000208	homodimer interface [polypeptide binding]; other site
717608000209	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
717608000210	active site
717608000211	homodimer interface [polypeptide binding]; other site
717608000212	catalytic site [active]
717608000213	K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927
717608000214	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
717608000215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608000216	FeS/SAM binding site; other site
717608000217	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
717608000218	nucleoside/Zn binding site; other site
717608000219	dimer interface [polypeptide binding]; other site
717608000220	catalytic motif [active]
717608000221	6-phosphofructokinase; Provisional; Region: PRK03202
717608000222	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717608000223	active site
717608000224	ADP/pyrophosphate binding site [chemical binding]; other site
717608000225	dimerization interface [polypeptide binding]; other site
717608000226	allosteric effector site; other site
717608000227	fructose-1,6-bisphosphate binding site; other site
717608000228	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
717608000229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000230	Walker A motif; other site
717608000231	ATP binding site [chemical binding]; other site
717608000232	Walker B motif; other site
717608000233	arginine finger; other site
717608000234	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
717608000235	recombination protein RecR; Reviewed; Region: recR; PRK00076
717608000236	RecR protein; Region: RecR; pfam02132
717608000237	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
717608000238	putative active site [active]
717608000239	putative metal-binding site [ion binding]; other site
717608000240	tetramer interface [polypeptide binding]; other site
717608000241	Tetratricopeptide repeat; Region: TPR_16; pfam13432
717608000242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608000243	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717608000244	active site
717608000245	motif I; other site
717608000246	motif II; other site
717608000247	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608000248	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
717608000249	Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691
717608000250	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608000251	TPR motif; other site
717608000252	TPR repeat; Region: TPR_11; pfam13414
717608000253	binding surface
717608000254	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
717608000255	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
717608000256	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
717608000257	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
717608000258	Resistant to P. syringae 6; Provisional; Region: PLN03210
717608000259	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
717608000260	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
717608000261	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
717608000262	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
717608000263	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
717608000264	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
717608000265	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608000266	Methyltransferase domain; Region: Methyltransf_23; pfam13489
717608000267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608000268	S-adenosylmethionine binding site [chemical binding]; other site
717608000269	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000270	H-loop/switch region; other site
717608000271	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608000272	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608000273	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608000274	putative catalytic residues [active]
717608000275	catalytic nucleophile [active]
717608000276	Recombinase; Region: Recombinase; pfam07508
717608000277	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608000278	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608000279	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
717608000280	Prophage antirepressor [Transcription]; Region: COG3617
717608000281	BRO family, N-terminal domain; Region: Bro-N; smart01040
717608000282	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
717608000283	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
717608000284	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608000285	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608000286	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
717608000287	Walker A/P-loop; other site
717608000288	ATP binding site [chemical binding]; other site
717608000289	Q-loop/lid; other site
717608000290	ABC transporter signature motif; other site
717608000291	Walker B; other site
717608000292	D-loop; other site
717608000293	H-loop/switch region; other site
717608000294	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
717608000295	active site
717608000296	catalytic site [active]
717608000297	substrate binding site [chemical binding]; other site
717608000298	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
717608000299	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608000300	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
717608000301	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
717608000302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608000303	motif II; other site
717608000304	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
717608000305	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608000306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608000307	S-adenosylmethionine binding site [chemical binding]; other site
717608000308	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
717608000309	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608000310	Walker A motif; other site
717608000311	ATP binding site [chemical binding]; other site
717608000312	Walker B motif; other site
717608000313	Protein of unknown function (DUF2681); Region: DUF2681; pfam10883
717608000314	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717608000315	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
717608000316	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
717608000317	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717608000318	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608000319	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608000320	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608000321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608000322	dimer interface [polypeptide binding]; other site
717608000323	phosphorylation site [posttranslational modification]
717608000324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608000325	ATP binding site [chemical binding]; other site
717608000326	Mg2+ binding site [ion binding]; other site
717608000327	G-X-G motif; other site
717608000328	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608000329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608000330	active site
717608000331	phosphorylation site [posttranslational modification]
717608000332	intermolecular recognition site; other site
717608000333	dimerization interface [polypeptide binding]; other site
717608000334	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608000335	DNA binding site [nucleotide binding]
717608000336	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
717608000337	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
717608000338	dimer interface [polypeptide binding]; other site
717608000339	active site
717608000340	CoA binding pocket [chemical binding]; other site
717608000341	acyl carrier protein; Provisional; Region: acpP; PRK00982
717608000342	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
717608000343	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
717608000344	FMN binding site [chemical binding]; other site
717608000345	substrate binding site [chemical binding]; other site
717608000346	putative catalytic residue [active]
717608000347	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
717608000348	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
717608000349	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
717608000350	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
717608000351	NAD(P) binding site [chemical binding]; other site
717608000352	homotetramer interface [polypeptide binding]; other site
717608000353	homodimer interface [polypeptide binding]; other site
717608000354	active site
717608000355	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
717608000356	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
717608000357	dimer interface [polypeptide binding]; other site
717608000358	active site
717608000359	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
717608000360	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717608000361	carboxyltransferase (CT) interaction site; other site
717608000362	biotinylation site [posttranslational modification]; other site
717608000363	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
717608000364	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
717608000365	C1-like domain; Region: C1_3; pfam07649
717608000366	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
717608000367	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
717608000368	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
717608000369	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
717608000370	FMN binding site [chemical binding]; other site
717608000371	substrate binding site [chemical binding]; other site
717608000372	putative catalytic residue [active]
717608000373	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
717608000374	ArsC family; Region: ArsC; pfam03960
717608000375	putative ArsC-like catalytic residues; other site
717608000376	putative TRX-like catalytic residues [active]
717608000377	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
717608000378	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717608000379	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
717608000380	DNA binding residues [nucleotide binding]
717608000381	dimer interface [polypeptide binding]; other site
717608000382	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
717608000383	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717608000384	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717608000385	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
717608000386	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
717608000387	Predicted membrane protein [Function unknown]; Region: COG3212
717608000388	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
717608000389	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
717608000390	Transcriptional regulators [Transcription]; Region: GntR; COG1802
717608000391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608000392	DNA-binding site [nucleotide binding]; DNA binding site
717608000393	FCD domain; Region: FCD; pfam07729
717608000394	Predicted amidohydrolase [General function prediction only]; Region: COG0388
717608000395	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
717608000396	putative active site [active]
717608000397	catalytic triad [active]
717608000398	putative dimer interface [polypeptide binding]; other site
717608000399	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
717608000400	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
717608000401	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
717608000402	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
717608000403	DctM-like transporters; Region: DctM; pfam06808
717608000404	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
717608000405	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
717608000406	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
717608000407	active site
717608000408	HIGH motif; other site
717608000409	KMSKS motif; other site
717608000410	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
717608000411	tRNA binding surface [nucleotide binding]; other site
717608000412	anticodon binding site; other site
717608000413	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
717608000414	dimer interface [polypeptide binding]; other site
717608000415	putative tRNA-binding site [nucleotide binding]; other site
717608000416	EcsC protein family; Region: EcsC; pfam12787
717608000417	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
717608000418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608000419	S-adenosylmethionine binding site [chemical binding]; other site
717608000420	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608000421	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000422	active site
717608000423	DNA binding site [nucleotide binding]
717608000424	Int/Topo IB signature motif; other site
717608000425	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000426	active site
717608000427	DNA binding site [nucleotide binding]
717608000428	Int/Topo IB signature motif; other site
717608000429	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
717608000430	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
717608000431	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000432	active site
717608000433	DNA binding site [nucleotide binding]
717608000434	Int/Topo IB signature motif; other site
717608000435	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
717608000436	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
717608000437	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608000438	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
717608000439	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717608000440	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608000441	catalytic residue [active]
717608000442	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
717608000443	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
717608000444	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
717608000445	active site
717608000446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000447	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
717608000448	Walker A motif; other site
717608000449	ATP binding site [chemical binding]; other site
717608000450	Walker B motif; other site
717608000451	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
717608000452	arginine finger; other site
717608000453	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
717608000454	Predicted methyltransferases [General function prediction only]; Region: COG0313
717608000455	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
717608000456	putative SAM binding site [chemical binding]; other site
717608000457	putative homodimer interface [polypeptide binding]; other site
717608000458	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717608000459	metal-binding site [ion binding]
717608000460	glycogen branching enzyme; Provisional; Region: PRK12313
717608000461	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
717608000462	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
717608000463	active site
717608000464	catalytic site [active]
717608000465	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
717608000466	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
717608000467	active site
717608000468	intersubunit interactions; other site
717608000469	catalytic residue [active]
717608000470	AAA domain; Region: AAA_31; pfam13614
717608000471	O-Antigen ligase; Region: Wzy_C; pfam04932
717608000472	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
717608000473	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
717608000474	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
717608000475	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
717608000476	NAD(P) binding site [chemical binding]; other site
717608000477	homodimer interface [polypeptide binding]; other site
717608000478	substrate binding site [chemical binding]; other site
717608000479	active site
717608000480	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
717608000481	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
717608000482	putative active site [active]
717608000483	metal binding site [ion binding]; metal-binding site
717608000484	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717608000485	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
717608000486	Coenzyme A binding pocket [chemical binding]; other site
717608000487	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717608000488	Int/Topo IB signature motif; other site
717608000489	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608000490	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
717608000491	active site
717608000492	catalytic residues [active]
717608000493	metal binding site [ion binding]; metal-binding site
717608000494	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717608000495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608000496	motif II; other site
717608000497	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
717608000498	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
717608000499	Ligand binding site; other site
717608000500	oligomer interface; other site
717608000501	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
717608000502	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
717608000503	PYR/PP interface [polypeptide binding]; other site
717608000504	dimer interface [polypeptide binding]; other site
717608000505	TPP binding site [chemical binding]; other site
717608000506	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
717608000507	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
717608000508	TPP-binding site [chemical binding]; other site
717608000509	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717608000510	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
717608000511	Ligand binding site; other site
717608000512	Putative Catalytic site; other site
717608000513	DXD motif; other site
717608000514	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
717608000515	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
717608000516	Probable Catalytic site; other site
717608000517	metal-binding site
717608000518	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
717608000519	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
717608000520	Probable Catalytic site; other site
717608000521	metal-binding site
717608000522	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
717608000523	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
717608000524	Probable Catalytic site; other site
717608000525	metal-binding site
717608000526	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
717608000527	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
717608000528	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
717608000529	Bacterial sugar transferase; Region: Bac_transf; pfam02397
717608000530	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
717608000531	Flavodoxin domain; Region: Flavodoxin_5; cl17428
717608000532	4Fe-4S binding domain; Region: Fer4; cl02805
717608000533	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717608000534	Flavin Reductases; Region: FlaRed; cl00801
717608000535	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
717608000536	catalytic loop [active]
717608000537	iron binding site [ion binding]; other site
717608000538	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
717608000539	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
717608000540	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717608000541	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
717608000542	Chromate transporter; Region: Chromate_transp; pfam02417
717608000543	Chromate transporter; Region: Chromate_transp; pfam02417
717608000544	Transcriptional regulators [Transcription]; Region: MarR; COG1846
717608000545	MarR family; Region: MarR_2; pfam12802
717608000546	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608000547	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608000548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000549	Walker A/P-loop; other site
717608000550	ATP binding site [chemical binding]; other site
717608000551	Q-loop/lid; other site
717608000552	ABC transporter signature motif; other site
717608000553	Walker B; other site
717608000554	D-loop; other site
717608000555	H-loop/switch region; other site
717608000556	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608000557	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608000558	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717608000559	Walker A/P-loop; other site
717608000560	ATP binding site [chemical binding]; other site
717608000561	Q-loop/lid; other site
717608000562	ABC transporter signature motif; other site
717608000563	Walker B; other site
717608000564	D-loop; other site
717608000565	H-loop/switch region; other site
717608000566	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
717608000567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608000568	DNA-binding site [nucleotide binding]; DNA binding site
717608000569	UTRA domain; Region: UTRA; pfam07702
717608000570	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
717608000571	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
717608000572	Ca binding site [ion binding]; other site
717608000573	active site
717608000574	catalytic site [active]
717608000575	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
717608000576	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717608000577	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717608000578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608000579	dimer interface [polypeptide binding]; other site
717608000580	conserved gate region; other site
717608000581	putative PBP binding loops; other site
717608000582	ABC-ATPase subunit interface; other site
717608000583	Bacterial SH3 domain homologues; Region: SH3b; smart00287
717608000584	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717608000585	NlpC/P60 family; Region: NLPC_P60; pfam00877
717608000586	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
717608000587	active site residue [active]
717608000588	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
717608000589	active site
717608000590	dimerization interface [polypeptide binding]; other site
717608000591	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
717608000592	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717608000593	active site
717608000594	metal binding site [ion binding]; metal-binding site
717608000595	homotetramer interface [polypeptide binding]; other site
717608000596	pyruvate formate lyase II activase; Provisional; Region: PRK10076
717608000597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608000598	FeS/SAM binding site; other site
717608000599	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
717608000600	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
717608000601	dimer interface [polypeptide binding]; other site
717608000602	active site
717608000603	glycine loop; other site
717608000604	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
717608000605	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
717608000606	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717608000607	minor groove reading motif; other site
717608000608	helix-hairpin-helix signature motif; other site
717608000609	substrate binding pocket [chemical binding]; other site
717608000610	active site
717608000611	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608000612	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608000613	Walker A/P-loop; other site
717608000614	ATP binding site [chemical binding]; other site
717608000615	Q-loop/lid; other site
717608000616	ABC transporter signature motif; other site
717608000617	Walker B; other site
717608000618	D-loop; other site
717608000619	H-loop/switch region; other site
717608000620	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608000621	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608000622	FtsX-like permease family; Region: FtsX; pfam02687
717608000623	Uncharacterized conserved protein [Function unknown]; Region: COG1624
717608000624	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
717608000625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
717608000626	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717608000627	dimerization domain swap beta strand [polypeptide binding]; other site
717608000628	regulatory protein interface [polypeptide binding]; other site
717608000629	active site
717608000630	regulatory phosphorylation site [posttranslational modification]; other site
717608000631	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
717608000632	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
717608000633	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
717608000634	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
717608000635	aspartate aminotransferase; Provisional; Region: PRK06836
717608000636	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608000637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608000638	homodimer interface [polypeptide binding]; other site
717608000639	catalytic residue [active]
717608000640	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
717608000641	Domain of unknown function DUF20; Region: UPF0118; pfam01594
717608000642	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
717608000643	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
717608000644	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
717608000645	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
717608000646	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717608000647	active site
717608000648	metal binding site [ion binding]; metal-binding site
717608000649	Sporulation related domain; Region: SPOR; pfam05036
717608000650	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
717608000651	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
717608000652	nucleotide binding pocket [chemical binding]; other site
717608000653	K-X-D-G motif; other site
717608000654	catalytic site [active]
717608000655	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
717608000656	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
717608000657	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
717608000658	Dimer interface [polypeptide binding]; other site
717608000659	Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908
717608000660	dinuclear metal binding motif [ion binding]; other site
717608000661	Homoserine O-succinyltransferase; Region: HTS; pfam04204
717608000662	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
717608000663	proposed active site lysine [active]
717608000664	conserved cys residue [active]
717608000665	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
717608000666	Peptidase family M28; Region: Peptidase_M28; pfam04389
717608000667	metal binding site [ion binding]; metal-binding site
717608000668	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717608000669	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608000670	Coenzyme A binding pocket [chemical binding]; other site
717608000671	SnoaL-like domain; Region: SnoaL_3; pfam13474
717608000672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
717608000673	PAS fold; Region: PAS_3; pfam08447
717608000674	putative active site [active]
717608000675	heme pocket [chemical binding]; other site
717608000676	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717608000677	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608000678	metal binding site [ion binding]; metal-binding site
717608000679	active site
717608000680	I-site; other site
717608000681	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
717608000682	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
717608000683	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608000684	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608000685	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
717608000686	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
717608000687	Sulfate transporter family; Region: Sulfate_transp; pfam00916
717608000688	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
717608000689	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
717608000690	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
717608000691	Clp amino terminal domain; Region: Clp_N; pfam02861
717608000692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000693	Walker A motif; other site
717608000694	ATP binding site [chemical binding]; other site
717608000695	Walker B motif; other site
717608000696	arginine finger; other site
717608000697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608000698	Walker A motif; other site
717608000699	ATP binding site [chemical binding]; other site
717608000700	Walker B motif; other site
717608000701	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717608000702	coenzyme F420 hydrogenase, subunit beta; Region: frhB; TIGR03289
717608000703	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608000704	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
717608000705	Amino acid permease; Region: AA_permease_2; pfam13520
717608000706	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
717608000707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608000708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608000709	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608000710	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
717608000711	metal binding site [ion binding]; metal-binding site
717608000712	dimer interface [polypeptide binding]; other site
717608000713	Peptidase C26; Region: Peptidase_C26; pfam07722
717608000714	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
717608000715	catalytic triad [active]
717608000716	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
717608000717	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
717608000718	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
717608000719	Ferritin-like domain; Region: Ferritin; pfam00210
717608000720	ferroxidase diiron center [ion binding]; other site
717608000721	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
717608000722	homodimer interface [polypeptide binding]; other site
717608000723	homotetramer interface [polypeptide binding]; other site
717608000724	active site pocket [active]
717608000725	cleavage site
717608000726	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
717608000727	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
717608000728	catalytic triad [active]
717608000729	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
717608000730	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
717608000731	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
717608000732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608000733	dimer interface [polypeptide binding]; other site
717608000734	conserved gate region; other site
717608000735	ABC-ATPase subunit interface; other site
717608000736	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
717608000737	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717608000738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608000739	dimer interface [polypeptide binding]; other site
717608000740	conserved gate region; other site
717608000741	putative PBP binding loops; other site
717608000742	ABC-ATPase subunit interface; other site
717608000743	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608000744	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608000745	Walker A/P-loop; other site
717608000746	ATP binding site [chemical binding]; other site
717608000747	Q-loop/lid; other site
717608000748	ABC transporter signature motif; other site
717608000749	Walker B; other site
717608000750	D-loop; other site
717608000751	H-loop/switch region; other site
717608000752	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608000753	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
717608000754	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608000755	Walker A/P-loop; other site
717608000756	ATP binding site [chemical binding]; other site
717608000757	Q-loop/lid; other site
717608000758	ABC transporter signature motif; other site
717608000759	Walker B; other site
717608000760	D-loop; other site
717608000761	H-loop/switch region; other site
717608000762	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608000763	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770
717608000764	SxDxEG motif; other site
717608000765	putative active site [active]
717608000766	putative metal binding site [ion binding]; other site
717608000767	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
717608000768	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
717608000769	oligomer interface [polypeptide binding]; other site
717608000770	active site
717608000771	metal binding site [ion binding]; metal-binding site
717608000772	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608000773	active site
717608000774	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
717608000775	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
717608000776	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
717608000777	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
717608000778	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
717608000779	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
717608000780	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
717608000781	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
717608000782	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
717608000783	active site
717608000784	substrate-binding site [chemical binding]; other site
717608000785	metal-binding site [ion binding]
717608000786	ATP binding site [chemical binding]; other site
717608000787	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608000788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608000789	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608000790	dimerization interface [polypeptide binding]; other site
717608000791	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
717608000792	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
717608000793	amidophosphoribosyltransferase; Provisional; Region: PRK05793
717608000794	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
717608000795	active site
717608000796	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608000797	active site
717608000798	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
717608000799	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
717608000800	NodB motif; other site
717608000801	active site
717608000802	catalytic site [active]
717608000803	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
717608000804	trimer interface [polypeptide binding]; other site
717608000805	putative Zn binding site [ion binding]; other site
717608000806	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
717608000807	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
717608000808	active site
717608000809	catalytic triad [active]
717608000810	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
717608000811	TrkA-N domain; Region: TrkA_N; pfam02254
717608000812	TrkA-C domain; Region: TrkA_C; pfam02080
717608000813	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
717608000814	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
717608000815	recombinase A; Provisional; Region: recA; PRK09354
717608000816	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
717608000817	hexamer interface [polypeptide binding]; other site
717608000818	Walker A motif; other site
717608000819	ATP binding site [chemical binding]; other site
717608000820	Walker B motif; other site
717608000821	recombination regulator RecX; Reviewed; Region: recX; PRK00117
717608000822	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
717608000823	pyrroline-5-carboxylate reductase; Region: PLN02688
717608000824	Integral membrane protein DUF95; Region: DUF95; cl00572
717608000825	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
717608000826	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
717608000827	active site
717608000828	Int/Topo IB signature motif; other site
717608000829	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608000830	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608000831	dimerization interface [polypeptide binding]; other site
717608000832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608000833	dimer interface [polypeptide binding]; other site
717608000834	phosphorylation site [posttranslational modification]
717608000835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608000836	ATP binding site [chemical binding]; other site
717608000837	Mg2+ binding site [ion binding]; other site
717608000838	G-X-G motif; other site
717608000839	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608000840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608000841	active site
717608000842	phosphorylation site [posttranslational modification]
717608000843	intermolecular recognition site; other site
717608000844	dimerization interface [polypeptide binding]; other site
717608000845	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608000846	DNA binding site [nucleotide binding]
717608000847	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
717608000848	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
717608000849	HlyD family secretion protein; Region: HlyD_3; pfam13437
717608000850	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
717608000851	Protein export membrane protein; Region: SecD_SecF; cl14618
717608000852	Outer membrane efflux protein; Region: OEP; pfam02321
717608000853	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
717608000854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
717608000855	Coenzyme A binding pocket [chemical binding]; other site
717608000856	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717608000857	nucleotide binding site [chemical binding]; other site
717608000858	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
717608000859	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717608000860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
717608000861	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
717608000862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
717608000863	Nucleoporin protein Ndc1-Nup; Region: Ndc1_Nup; pfam09531
717608000864	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
717608000865	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
717608000866	domain interfaces; other site
717608000867	active site
717608000868	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
717608000869	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
717608000870	active site
717608000871	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717608000872	substrate binding site [chemical binding]; other site
717608000873	catalytic residues [active]
717608000874	dimer interface [polypeptide binding]; other site
717608000875	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
717608000876	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717608000877	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608000878	metal binding site [ion binding]; metal-binding site
717608000879	active site
717608000880	I-site; other site
717608000881	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
717608000882	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
717608000883	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
717608000884	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
717608000885	DHHW protein; Region: DHHW; pfam14286
717608000886	DHHW protein; Region: DHHW; pfam14286
717608000887	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717608000888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000889	Walker A/P-loop; other site
717608000890	ATP binding site [chemical binding]; other site
717608000891	Q-loop/lid; other site
717608000892	ABC transporter signature motif; other site
717608000893	Walker B; other site
717608000894	D-loop; other site
717608000895	H-loop/switch region; other site
717608000896	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
717608000897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608000898	dimer interface [polypeptide binding]; other site
717608000899	conserved gate region; other site
717608000900	putative PBP binding loops; other site
717608000901	ABC-ATPase subunit interface; other site
717608000902	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
717608000903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
717608000904	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
717608000905	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717608000906	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
717608000907	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
717608000908	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
717608000909	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
717608000910	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
717608000911	putative L-serine binding site [chemical binding]; other site
717608000912	DGQHR domain; Region: DGQHR; TIGR03187
717608000913	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000914	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000915	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000916	active site
717608000917	DNA binding site [nucleotide binding]
717608000918	Int/Topo IB signature motif; other site
717608000919	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000920	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608000921	active site
717608000922	DNA binding site [nucleotide binding]
717608000923	Int/Topo IB signature motif; other site
717608000924	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000925	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000926	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000927	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000928	PemK-like protein; Region: PemK; pfam02452
717608000929	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717608000930	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717608000931	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717608000932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717608000933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608000934	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608000935	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608000936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000937	Walker A/P-loop; other site
717608000938	ATP binding site [chemical binding]; other site
717608000939	Q-loop/lid; other site
717608000940	ABC transporter signature motif; other site
717608000941	Walker B; other site
717608000942	D-loop; other site
717608000943	H-loop/switch region; other site
717608000944	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608000945	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608000946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608000947	Walker A/P-loop; other site
717608000948	ATP binding site [chemical binding]; other site
717608000949	Q-loop/lid; other site
717608000950	ABC transporter signature motif; other site
717608000951	Walker B; other site
717608000952	D-loop; other site
717608000953	H-loop/switch region; other site
717608000954	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
717608000955	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
717608000956	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717608000957	Walker A/P-loop; other site
717608000958	ATP binding site [chemical binding]; other site
717608000959	Q-loop/lid; other site
717608000960	ABC transporter signature motif; other site
717608000961	Walker B; other site
717608000962	D-loop; other site
717608000963	H-loop/switch region; other site
717608000964	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
717608000965	Walker A/P-loop; other site
717608000966	ATP binding site [chemical binding]; other site
717608000967	Q-loop/lid; other site
717608000968	ABC transporter signature motif; other site
717608000969	Walker B; other site
717608000970	D-loop; other site
717608000971	H-loop/switch region; other site
717608000972	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608000973	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608000974	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
717608000975	Acyltransferase family; Region: Acyl_transf_3; pfam01757
717608000976	alanine racemase; Reviewed; Region: alr; PRK00053
717608000977	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
717608000978	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717608000979	catalytic residue [active]
717608000980	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
717608000981	Sif protein; Region: Sif; cl11505
717608000982	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
717608000983	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
717608000984	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
717608000985	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608000986	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717608000987	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608000988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608000989	active site
717608000990	phosphorylation site [posttranslational modification]
717608000991	intermolecular recognition site; other site
717608000992	dimerization interface [polypeptide binding]; other site
717608000993	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608000994	DNA binding site [nucleotide binding]
717608000995	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608000996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608000997	non-specific DNA binding site [nucleotide binding]; other site
717608000998	salt bridge; other site
717608000999	sequence-specific DNA binding site [nucleotide binding]; other site
717608001000	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608001001	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
717608001002	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
717608001003	Protein of unknown function (DUF3848); Region: DUF3848; pfam12959
717608001004	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
717608001005	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717608001006	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
717608001007	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
717608001008	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
717608001009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608001010	ATP binding site [chemical binding]; other site
717608001011	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
717608001012	helicase superfamily c-terminal domain; Region: HELICc; smart00490
717608001013	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
717608001014	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608001015	YodL-like; Region: YodL; pfam14191
717608001016	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
717608001017	DNA topoisomerase III; Provisional; Region: PRK07726
717608001018	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717608001019	active site
717608001020	putative interdomain interaction site [polypeptide binding]; other site
717608001021	putative metal-binding site [ion binding]; other site
717608001022	putative nucleotide binding site [chemical binding]; other site
717608001023	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717608001024	domain I; other site
717608001025	DNA binding groove [nucleotide binding]
717608001026	phosphate binding site [ion binding]; other site
717608001027	domain II; other site
717608001028	domain III; other site
717608001029	nucleotide binding site [chemical binding]; other site
717608001030	catalytic site [active]
717608001031	domain IV; other site
717608001032	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
717608001033	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717608001034	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
717608001035	Protein of unknown function (DUF3851); Region: DUF3851; pfam12962
717608001036	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717608001037	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608001038	PrgI family protein; Region: PrgI; pfam12666
717608001039	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
717608001040	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
717608001041	putative active site [active]
717608001042	putative NTP binding site [chemical binding]; other site
717608001043	putative nucleic acid binding site [nucleotide binding]; other site
717608001044	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717608001045	Type II intron maturase; Region: Intron_maturas2; pfam01348
717608001046	Maff2 family; Region: Maff2; pfam12750
717608001047	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608001048	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
717608001049	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608001050	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
717608001051	Prophage antirepressor [Transcription]; Region: COG3617
717608001052	BRO family, N-terminal domain; Region: Bro-N; smart01040
717608001053	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
717608001054	Helix-turn-helix domain; Region: HTH_36; pfam13730
717608001055	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
717608001056	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001057	active site
717608001058	DNA binding site [nucleotide binding]
717608001059	Int/Topo IB signature motif; other site
717608001060	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001061	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001062	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001063	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001064	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001065	PemK-like protein; Region: PemK; pfam02452
717608001066	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
717608001068	DNA binding residues [nucleotide binding]
717608001069	DNA polymerase IV; Reviewed; Region: PRK03103
717608001070	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
717608001071	active site
717608001072	DNA binding site [nucleotide binding]
717608001073	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
717608001074	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608001075	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001076	non-specific DNA binding site [nucleotide binding]; other site
717608001077	salt bridge; other site
717608001078	sequence-specific DNA binding site [nucleotide binding]; other site
717608001079	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
717608001080	GIY-YIG motif/motif A; other site
717608001081	putative active site [active]
717608001082	putative metal binding site [ion binding]; other site
717608001083	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001084	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608001085	DNA binding residues [nucleotide binding]
717608001086	Major Facilitator Superfamily; Region: MFS_1; pfam07690
717608001087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717608001088	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
717608001089	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
717608001090	G1 box; other site
717608001091	putative GEF interaction site [polypeptide binding]; other site
717608001092	GTP/Mg2+ binding site [chemical binding]; other site
717608001093	Switch I region; other site
717608001094	G2 box; other site
717608001095	G3 box; other site
717608001096	Switch II region; other site
717608001097	G4 box; other site
717608001098	G5 box; other site
717608001099	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
717608001100	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
717608001101	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
717608001102	TIGR02594 family protein; Region: TIGR02594
717608001103	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
717608001104	active site
717608001105	catalytic site [active]
717608001106	AAA-like domain; Region: AAA_10; pfam12846
717608001107	Domain of unknown function DUF87; Region: DUF87; pfam01935
717608001108	PrgI family protein; Region: PrgI; pfam12666
717608001109	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717608001110	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
717608001111	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
717608001112	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
717608001113	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
717608001114	Toprim-like; Region: Toprim_2; pfam13155
717608001115	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
717608001116	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
717608001117	Cna protein B-type domain; Region: Cna_B; pfam05738
717608001118	Cna protein B-type domain; Region: Cna_B; pfam05738
717608001119	Cna protein B-type domain; Region: Cna_B; pfam05738
717608001120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
717608001121	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
717608001122	ParB-like nuclease domain; Region: ParBc; pfam02195
717608001123	Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997
717608001124	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
717608001125	ParB-like nuclease domain; Region: ParB; smart00470
717608001126	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
717608001127	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608001128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
717608001129	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
717608001130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608001131	S-adenosylmethionine binding site [chemical binding]; other site
717608001132	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
717608001133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608001134	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
717608001135	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
717608001136	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
717608001137	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
717608001138	trmE is a tRNA modification GTPase; Region: trmE; cd04164
717608001139	G1 box; other site
717608001140	GTP/Mg2+ binding site [chemical binding]; other site
717608001141	Switch I region; other site
717608001142	G2 box; other site
717608001143	Switch II region; other site
717608001144	G3 box; other site
717608001145	G4 box; other site
717608001146	G5 box; other site
717608001147	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
717608001148	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
717608001149	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
717608001150	G-X-X-G motif; other site
717608001151	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
717608001152	RxxxH motif; other site
717608001153	ribonuclease P; Reviewed; Region: rnpA; PRK00499
717608001154	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
717608001155	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
717608001156	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
717608001157	DnaA N-terminal domain; Region: DnaA_N; pfam11638
717608001158	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
717608001159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608001160	Walker A motif; other site
717608001161	ATP binding site [chemical binding]; other site
717608001162	Walker B motif; other site
717608001163	arginine finger; other site
717608001164	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
717608001165	DnaA box-binding interface [nucleotide binding]; other site
717608001166	DNA polymerase III subunit beta; Validated; Region: PRK05643
717608001167	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
717608001168	putative DNA binding surface [nucleotide binding]; other site
717608001169	dimer interface [polypeptide binding]; other site
717608001170	beta-clamp/clamp loader binding surface; other site
717608001171	beta-clamp/translesion DNA polymerase binding surface; other site
717608001172	S4 domain; Region: S4_2; pfam13275
717608001173	recombination protein F; Reviewed; Region: recF; PRK00064
717608001174	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
717608001175	Walker A/P-loop; other site
717608001176	ATP binding site [chemical binding]; other site
717608001177	Q-loop/lid; other site
717608001178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001179	ABC transporter signature motif; other site
717608001180	Walker B; other site
717608001181	D-loop; other site
717608001182	H-loop/switch region; other site
717608001183	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
717608001184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001185	Mg2+ binding site [ion binding]; other site
717608001186	G-X-G motif; other site
717608001187	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
717608001188	anchoring element; other site
717608001189	dimer interface [polypeptide binding]; other site
717608001190	ATP binding site [chemical binding]; other site
717608001191	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
717608001192	active site
717608001193	putative metal-binding site [ion binding]; other site
717608001194	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
717608001195	DNA gyrase subunit A; Validated; Region: PRK05560
717608001196	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
717608001197	CAP-like domain; other site
717608001198	active site
717608001199	primary dimer interface [polypeptide binding]; other site
717608001200	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001201	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001202	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001203	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001204	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001205	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608001206	fumarate hydratase; Provisional; Region: PRK06246
717608001207	Fumarase C-terminus; Region: Fumerase_C; cl00795
717608001208	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
717608001209	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001210	active site
717608001211	DNA binding site [nucleotide binding]
717608001212	Int/Topo IB signature motif; other site
717608001213	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
717608001214	Putative transposase; Region: Y2_Tnp; pfam04986
717608001215	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717608001216	MarR family; Region: MarR_2; pfam12802
717608001217	FtsH Extracellular; Region: FtsH_ext; pfam06480
717608001218	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
717608001219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608001220	Walker A motif; other site
717608001221	ATP binding site [chemical binding]; other site
717608001222	Walker B motif; other site
717608001223	arginine finger; other site
717608001224	Peptidase family M41; Region: Peptidase_M41; pfam01434
717608001225	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
717608001226	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
717608001227	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
717608001228	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
717608001229	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
717608001230	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
717608001231	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717608001232	Int/Topo IB signature motif; other site
717608001233	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
717608001234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001235	non-specific DNA binding site [nucleotide binding]; other site
717608001236	salt bridge; other site
717608001237	sequence-specific DNA binding site [nucleotide binding]; other site
717608001238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717608001239	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
717608001240	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608001241	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
717608001242	active site
717608001243	catalytic site [active]
717608001244	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
717608001245	Mg binding site [ion binding]; other site
717608001246	nucleotide binding site [chemical binding]; other site
717608001247	putative protofilament interface [polypeptide binding]; other site
717608001248	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001249	non-specific DNA binding site [nucleotide binding]; other site
717608001250	salt bridge; other site
717608001251	sequence-specific DNA binding site [nucleotide binding]; other site
717608001252	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001253	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
717608001254	DNA binding residues [nucleotide binding]
717608001255	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608001256	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608001257	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608001258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608001259	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
717608001260	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717608001261	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
717608001262	Walker A/P-loop; other site
717608001263	ATP binding site [chemical binding]; other site
717608001264	Q-loop/lid; other site
717608001265	ABC transporter signature motif; other site
717608001266	Walker B; other site
717608001267	D-loop; other site
717608001268	H-loop/switch region; other site
717608001269	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717608001270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001271	Walker A/P-loop; other site
717608001272	ATP binding site [chemical binding]; other site
717608001273	Q-loop/lid; other site
717608001274	ABC transporter signature motif; other site
717608001275	Walker B; other site
717608001276	D-loop; other site
717608001277	H-loop/switch region; other site
717608001278	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
717608001279	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608001280	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608001281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001282	Walker A/P-loop; other site
717608001283	ATP binding site [chemical binding]; other site
717608001284	Q-loop/lid; other site
717608001285	ABC transporter signature motif; other site
717608001286	Walker B; other site
717608001287	D-loop; other site
717608001288	H-loop/switch region; other site
717608001289	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608001290	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608001291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001292	Walker A/P-loop; other site
717608001293	ATP binding site [chemical binding]; other site
717608001294	Q-loop/lid; other site
717608001295	ABC transporter signature motif; other site
717608001296	Walker B; other site
717608001297	D-loop; other site
717608001298	H-loop/switch region; other site
717608001299	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717608001300	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717608001301	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717608001302	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001303	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001304	DNA binding site [nucleotide binding]
717608001305	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
717608001306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001307	Walker B; other site
717608001308	D-loop; other site
717608001309	H-loop/switch region; other site
717608001310	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717608001311	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
717608001312	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
717608001313	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001314	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717608001315	AAA domain; Region: AAA_14; pfam13173
717608001316	AAA domain; Region: AAA_14; pfam13173
717608001317	The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397
717608001318	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
717608001319	YodL-like; Region: YodL; pfam14191
717608001320	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
717608001321	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
717608001322	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
717608001323	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
717608001324	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
717608001325	nucleotide binding pocket [chemical binding]; other site
717608001326	K-X-D-G motif; other site
717608001327	catalytic site [active]
717608001328	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
717608001329	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
717608001330	Dimer interface [polypeptide binding]; other site
717608001331	DNA polymerase IV; Reviewed; Region: PRK03103
717608001332	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
717608001333	active site
717608001334	DNA binding site [nucleotide binding]
717608001335	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
717608001336	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
717608001337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001339	dimer interface [polypeptide binding]; other site
717608001340	phosphorylation site [posttranslational modification]
717608001341	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
717608001342	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
717608001343	G1 box; other site
717608001344	putative GEF interaction site [polypeptide binding]; other site
717608001345	GTP/Mg2+ binding site [chemical binding]; other site
717608001346	Switch I region; other site
717608001347	G2 box; other site
717608001348	G3 box; other site
717608001349	Switch II region; other site
717608001350	G4 box; other site
717608001351	G5 box; other site
717608001352	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
717608001353	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
717608001354	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
717608001355	Methyltransferase domain; Region: Methyltransf_31; pfam13847
717608001356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608001357	S-adenosylmethionine binding site [chemical binding]; other site
717608001358	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
717608001360	DNA binding residues [nucleotide binding]
717608001361	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608001362	T-DNA border endonuclease VirD1; Region: VirD1; cl17530
717608001363	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
717608001364	hypothetical protein; Validated; Region: PRK08116
717608001365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608001366	Walker A motif; other site
717608001367	ATP binding site [chemical binding]; other site
717608001368	Walker B motif; other site
717608001369	arginine finger; other site
717608001370	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608001371	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608001372	putative catalytic residues [active]
717608001373	catalytic nucleophile [active]
717608001374	Recombinase; Region: Recombinase; pfam07508
717608001375	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608001376	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608001377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001379	ATP binding site [chemical binding]; other site
717608001380	Mg2+ binding site [ion binding]; other site
717608001381	G-X-G motif; other site
717608001382	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001383	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001384	Walker A/P-loop; other site
717608001385	ATP binding site [chemical binding]; other site
717608001386	Q-loop/lid; other site
717608001387	ABC transporter signature motif; other site
717608001388	Walker B; other site
717608001389	D-loop; other site
717608001390	H-loop/switch region; other site
717608001391	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608001392	FtsX-like permease family; Region: FtsX; pfam02687
717608001393	FtsX-like permease family; Region: FtsX; pfam02687
717608001394	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608001395	FtsX-like permease family; Region: FtsX; pfam02687
717608001396	FtsX-like permease family; Region: FtsX; pfam02687
717608001397	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001398	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001399	Walker A/P-loop; other site
717608001400	ATP binding site [chemical binding]; other site
717608001401	Q-loop/lid; other site
717608001402	ABC transporter signature motif; other site
717608001403	Walker B; other site
717608001404	D-loop; other site
717608001405	H-loop/switch region; other site
717608001406	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001407	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001408	dimer interface [polypeptide binding]; other site
717608001409	phosphorylation site [posttranslational modification]
717608001410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001411	ATP binding site [chemical binding]; other site
717608001412	Mg2+ binding site [ion binding]; other site
717608001413	G-X-G motif; other site
717608001414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001416	active site
717608001417	phosphorylation site [posttranslational modification]
717608001418	intermolecular recognition site; other site
717608001419	dimerization interface [polypeptide binding]; other site
717608001420	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001421	DNA binding site [nucleotide binding]
717608001422	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608001423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001425	dimer interface [polypeptide binding]; other site
717608001426	phosphorylation site [posttranslational modification]
717608001427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001428	ATP binding site [chemical binding]; other site
717608001429	Mg2+ binding site [ion binding]; other site
717608001430	G-X-G motif; other site
717608001431	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001433	active site
717608001434	phosphorylation site [posttranslational modification]
717608001435	intermolecular recognition site; other site
717608001436	dimerization interface [polypeptide binding]; other site
717608001437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001438	DNA binding site [nucleotide binding]
717608001439	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608001440	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608001441	FtsX-like permease family; Region: FtsX; pfam02687
717608001442	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001443	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001444	Walker A/P-loop; other site
717608001445	ATP binding site [chemical binding]; other site
717608001446	Q-loop/lid; other site
717608001447	ABC transporter signature motif; other site
717608001448	Walker B; other site
717608001449	D-loop; other site
717608001450	H-loop/switch region; other site
717608001451	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001452	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001453	DNA binding site [nucleotide binding]
717608001454	Fic family protein [Function unknown]; Region: COG3177
717608001455	Fic/DOC family; Region: Fic; pfam02661
717608001456	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608001457	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001458	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
717608001459	DNA binding residues [nucleotide binding]
717608001460	stage V sporulation protein T; Region: spore_V_T; TIGR02851
717608001461	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
717608001462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
717608001463	Walker A motif; other site
717608001464	ATP binding site [chemical binding]; other site
717608001465	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
717608001466	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
717608001467	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
717608001468	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
717608001469	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
717608001470	Walker A/P-loop; other site
717608001471	ATP binding site [chemical binding]; other site
717608001472	Q-loop/lid; other site
717608001473	ABC transporter signature motif; other site
717608001474	Walker B; other site
717608001475	D-loop; other site
717608001476	H-loop/switch region; other site
717608001477	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
717608001478	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
717608001479	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001481	DNA binding site [nucleotide binding]
717608001482	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001484	active site
717608001485	phosphorylation site [posttranslational modification]
717608001486	intermolecular recognition site; other site
717608001487	dimerization interface [polypeptide binding]; other site
717608001488	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001489	DNA binding site [nucleotide binding]
717608001490	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
717608001491	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
717608001492	dimer interface [polypeptide binding]; other site
717608001493	substrate binding site [chemical binding]; other site
717608001494	ATP binding site [chemical binding]; other site
717608001495	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
717608001496	thiamine phosphate binding site [chemical binding]; other site
717608001497	active site
717608001498	pyrophosphate binding site [ion binding]; other site
717608001499	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
717608001500	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608001501	motif II; other site
717608001502	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
717608001503	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
717608001504	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
717608001505	nudix motif; other site
717608001506	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001507	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001508	Walker A/P-loop; other site
717608001509	ATP binding site [chemical binding]; other site
717608001510	Q-loop/lid; other site
717608001511	ABC transporter signature motif; other site
717608001512	Walker B; other site
717608001513	D-loop; other site
717608001514	H-loop/switch region; other site
717608001515	FtsX-like permease family; Region: FtsX; pfam02687
717608001516	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001518	active site
717608001519	phosphorylation site [posttranslational modification]
717608001520	intermolecular recognition site; other site
717608001521	dimerization interface [polypeptide binding]; other site
717608001522	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001523	DNA binding site [nucleotide binding]
717608001524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001526	ATP binding site [chemical binding]; other site
717608001527	Mg2+ binding site [ion binding]; other site
717608001528	G-X-G motif; other site
717608001529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001530	non-specific DNA binding site [nucleotide binding]; other site
717608001531	salt bridge; other site
717608001532	sequence-specific DNA binding site [nucleotide binding]; other site
717608001533	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
717608001534	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
717608001535	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
717608001536	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
717608001537	CAAX protease self-immunity; Region: Abi; pfam02517
717608001538	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717608001539	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608001540	Walker A/P-loop; other site
717608001541	ATP binding site [chemical binding]; other site
717608001542	Q-loop/lid; other site
717608001543	ABC transporter signature motif; other site
717608001544	Walker B; other site
717608001545	D-loop; other site
717608001546	H-loop/switch region; other site
717608001547	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717608001548	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608001549	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608001550	FtsX-like permease family; Region: FtsX; pfam02687
717608001551	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608001552	FtsX-like permease family; Region: FtsX; pfam02687
717608001553	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608001554	FtsX-like permease family; Region: FtsX; pfam02687
717608001555	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001556	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001557	Walker A/P-loop; other site
717608001558	ATP binding site [chemical binding]; other site
717608001559	Q-loop/lid; other site
717608001560	ABC transporter signature motif; other site
717608001561	Walker B; other site
717608001562	D-loop; other site
717608001563	H-loop/switch region; other site
717608001564	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001566	DNA binding site [nucleotide binding]
717608001567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001569	dimer interface [polypeptide binding]; other site
717608001570	phosphorylation site [posttranslational modification]
717608001571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001572	ATP binding site [chemical binding]; other site
717608001573	Mg2+ binding site [ion binding]; other site
717608001574	G-X-G motif; other site
717608001575	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608001576	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608001577	Walker A/P-loop; other site
717608001578	ATP binding site [chemical binding]; other site
717608001579	Q-loop/lid; other site
717608001580	ABC transporter signature motif; other site
717608001581	Walker B; other site
717608001582	D-loop; other site
717608001583	H-loop/switch region; other site
717608001584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001585	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001586	DNA binding site [nucleotide binding]
717608001587	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001589	dimer interface [polypeptide binding]; other site
717608001590	phosphorylation site [posttranslational modification]
717608001591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001592	ATP binding site [chemical binding]; other site
717608001593	Mg2+ binding site [ion binding]; other site
717608001594	G-X-G motif; other site
717608001595	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001597	active site
717608001598	phosphorylation site [posttranslational modification]
717608001599	intermolecular recognition site; other site
717608001600	dimerization interface [polypeptide binding]; other site
717608001601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001602	DNA binding site [nucleotide binding]
717608001603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608001604	ABC transporter signature motif; other site
717608001605	Walker B; other site
717608001606	D-loop; other site
717608001607	H-loop/switch region; other site
717608001608	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001610	DNA binding site [nucleotide binding]
717608001611	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
717608001612	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608001613	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001614	non-specific DNA binding site [nucleotide binding]; other site
717608001615	salt bridge; other site
717608001616	sequence-specific DNA binding site [nucleotide binding]; other site
717608001617	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608001618	Virulence-associated protein E; Region: VirE; pfam05272
717608001619	Archaeal ATPase; Region: Arch_ATPase; pfam01637
717608001620	AAA ATPase domain; Region: AAA_16; pfam13191
717608001621	AAA domain; Region: AAA_14; pfam13173
717608001622	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
717608001623	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
717608001624	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608001625	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608001626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
717608001627	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
717608001628	Transposase; Region: DDE_Tnp_ISL3; pfam01610
717608001629	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608001630	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
717608001631	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608001632	Walker A/P-loop; other site
717608001633	ATP binding site [chemical binding]; other site
717608001634	Q-loop/lid; other site
717608001635	ABC transporter signature motif; other site
717608001636	Walker B; other site
717608001637	D-loop; other site
717608001638	H-loop/switch region; other site
717608001639	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
717608001640	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
717608001641	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001642	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608001643	DNA binding residues [nucleotide binding]
717608001644	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608001645	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
717608001646	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608001647	Abi-like protein; Region: Abi_2; pfam07751
717608001648	AAA domain; Region: AAA_21; pfam13304
717608001649	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608001650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001651	non-specific DNA binding site [nucleotide binding]; other site
717608001652	salt bridge; other site
717608001653	sequence-specific DNA binding site [nucleotide binding]; other site
717608001654	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608001655	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
717608001656	catalytic residues [active]
717608001657	catalytic nucleophile [active]
717608001658	Presynaptic Site I dimer interface [polypeptide binding]; other site
717608001659	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
717608001660	Synaptic Flat tetramer interface [polypeptide binding]; other site
717608001661	Synaptic Site I dimer interface [polypeptide binding]; other site
717608001662	DNA binding site [nucleotide binding]
717608001663	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
717608001664	putative active site [active]
717608001665	catalytic site [active]
717608001666	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608001667	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
717608001668	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
717608001669	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001670	active site
717608001671	DNA binding site [nucleotide binding]
717608001672	Int/Topo IB signature motif; other site
717608001673	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
717608001674	Low molecular weight phosphatase family; Region: LMWPc; cd00115
717608001675	active site
717608001676	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
717608001677	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
717608001678	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
717608001679	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
717608001680	putative acyl-acceptor binding pocket; other site
717608001681	Chorismate mutase type II; Region: CM_2; pfam01817
717608001682	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
717608001683	Prephenate dehydratase; Region: PDT; pfam00800
717608001684	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
717608001685	putative L-Phe binding site [chemical binding]; other site
717608001686	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
717608001687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608001688	Walker A motif; other site
717608001689	ATP binding site [chemical binding]; other site
717608001690	Walker B motif; other site
717608001691	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
717608001692	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
717608001693	polyphosphate kinase; Provisional; Region: PRK05443
717608001694	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
717608001695	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
717608001696	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
717608001697	putative domain interface [polypeptide binding]; other site
717608001698	putative active site [active]
717608001699	catalytic site [active]
717608001700	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
717608001701	putative domain interface [polypeptide binding]; other site
717608001702	putative active site [active]
717608001703	catalytic site [active]
717608001704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608001705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001706	active site
717608001707	phosphorylation site [posttranslational modification]
717608001708	intermolecular recognition site; other site
717608001709	dimerization interface [polypeptide binding]; other site
717608001710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608001711	DNA binding site [nucleotide binding]
717608001712	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608001714	dimerization interface [polypeptide binding]; other site
717608001715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001716	dimer interface [polypeptide binding]; other site
717608001717	phosphorylation site [posttranslational modification]
717608001718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001719	ATP binding site [chemical binding]; other site
717608001720	Mg2+ binding site [ion binding]; other site
717608001721	G-X-G motif; other site
717608001722	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717608001723	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608001724	Walker A/P-loop; other site
717608001725	ATP binding site [chemical binding]; other site
717608001726	Q-loop/lid; other site
717608001727	ABC transporter signature motif; other site
717608001728	Walker B; other site
717608001729	D-loop; other site
717608001730	H-loop/switch region; other site
717608001731	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
717608001732	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
717608001733	endonuclease IV; Provisional; Region: PRK01060
717608001734	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
717608001735	AP (apurinic/apyrimidinic) site pocket; other site
717608001736	DNA interaction; other site
717608001737	Metal-binding active site; metal-binding site
717608001738	xanthine permease; Region: pbuX; TIGR03173
717608001739	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
717608001740	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
717608001741	active site
717608001742	NodB motif; other site
717608001743	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
717608001744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001745	active site
717608001746	phosphorylation site [posttranslational modification]
717608001747	intermolecular recognition site; other site
717608001748	dimerization interface [polypeptide binding]; other site
717608001749	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
717608001750	glycogen synthase; Provisional; Region: glgA; PRK00654
717608001751	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
717608001752	ADP-binding pocket [chemical binding]; other site
717608001753	homodimer interface [polypeptide binding]; other site
717608001754	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
717608001755	Divergent PAP2 family; Region: DUF212; pfam02681
717608001756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
717608001757	binding surface
717608001758	TPR motif; other site
717608001759	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608001760	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
717608001761	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
717608001762	inhibitor-cofactor binding pocket; inhibition site
717608001763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608001764	catalytic residue [active]
717608001765	AAA domain; Region: AAA_26; pfam13500
717608001766	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
717608001767	biotin synthase; Region: bioB; TIGR00433
717608001768	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608001769	FeS/SAM binding site; other site
717608001770	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
717608001771	BioY family; Region: BioY; pfam02632
717608001772	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
717608001773	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
717608001774	putative dimer interface [polypeptide binding]; other site
717608001775	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
717608001776	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
717608001777	Walker A/P-loop; other site
717608001778	ATP binding site [chemical binding]; other site
717608001779	Q-loop/lid; other site
717608001780	ABC transporter signature motif; other site
717608001781	Walker B; other site
717608001782	D-loop; other site
717608001783	H-loop/switch region; other site
717608001784	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
717608001785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608001786	dimer interface [polypeptide binding]; other site
717608001787	conserved gate region; other site
717608001788	putative PBP binding loops; other site
717608001789	ABC-ATPase subunit interface; other site
717608001790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608001791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608001792	dimer interface [polypeptide binding]; other site
717608001793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608001794	ATP binding site [chemical binding]; other site
717608001795	Mg2+ binding site [ion binding]; other site
717608001796	G-X-G motif; other site
717608001797	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717608001798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608001799	active site
717608001800	phosphorylation site [posttranslational modification]
717608001801	intermolecular recognition site; other site
717608001802	dimerization interface [polypeptide binding]; other site
717608001803	nitrilase; Region: PLN02798
717608001804	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
717608001805	putative active site [active]
717608001806	catalytic triad [active]
717608001807	dimer interface [polypeptide binding]; other site
717608001808	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717608001809	FMN binding site [chemical binding]; other site
717608001810	dimer interface [polypeptide binding]; other site
717608001811	ribosome maturation protein RimP; Reviewed; Region: PRK00092
717608001812	Sm and related proteins; Region: Sm_like; cl00259
717608001813	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
717608001814	putative oligomer interface [polypeptide binding]; other site
717608001815	putative RNA binding site [nucleotide binding]; other site
717608001816	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
717608001817	NusA N-terminal domain; Region: NusA_N; pfam08529
717608001818	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
717608001819	RNA binding site [nucleotide binding]; other site
717608001820	homodimer interface [polypeptide binding]; other site
717608001821	NusA-like KH domain; Region: KH_5; pfam13184
717608001822	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
717608001823	G-X-X-G motif; other site
717608001824	translation initiation factor IF-2; Region: IF-2; TIGR00487
717608001825	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
717608001826	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
717608001827	G1 box; other site
717608001828	putative GEF interaction site [polypeptide binding]; other site
717608001829	GTP/Mg2+ binding site [chemical binding]; other site
717608001830	Switch I region; other site
717608001831	G2 box; other site
717608001832	G3 box; other site
717608001833	Switch II region; other site
717608001834	G4 box; other site
717608001835	G5 box; other site
717608001836	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
717608001837	Translation-initiation factor 2; Region: IF-2; pfam11987
717608001838	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
717608001839	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
717608001840	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
717608001841	DHH family; Region: DHH; pfam01368
717608001842	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
717608001843	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
717608001844	RNA binding site [nucleotide binding]; other site
717608001845	active site
717608001846	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
717608001847	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
717608001848	active site
717608001849	Riboflavin kinase; Region: Flavokinase; pfam01687
717608001850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608001851	Coenzyme A binding pocket [chemical binding]; other site
717608001852	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
717608001853	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
717608001854	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717608001855	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717608001856	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
717608001857	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717608001858	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717608001859	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
717608001860	IMP binding site; other site
717608001861	dimer interface [polypeptide binding]; other site
717608001862	interdomain contacts; other site
717608001863	partial ornithine binding site; other site
717608001864	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608001865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608001866	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608001867	DNA binding residues [nucleotide binding]
717608001868	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
717608001869	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
717608001870	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
717608001871	CPxP  motif; other site
717608001872	DsrE/DsrF-like family; Region: DrsE; pfam02635
717608001873	Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160
717608001874	putative homodimer interface [polypeptide binding]; other site
717608001875	putative homotetramer interface [polypeptide binding]; other site
717608001876	putative metal binding site [ion binding]; other site
717608001877	putative homodimer-homodimer interface [polypeptide binding]; other site
717608001878	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
717608001879	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608001880	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
717608001881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608001882	motif II; other site
717608001883	chorismate binding enzyme; Region: Chorismate_bind; cl10555
717608001884	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
717608001885	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355
717608001886	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
717608001887	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
717608001888	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
717608001889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717608001890	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
717608001891	catalytic residues [active]
717608001892	Glycine reductase complex selenoprotein A; Region: GRDA; cl04705
717608001893	Glycine reductase complex selenoprotein A; Region: GRDA; cl04705
717608001894	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
717608001895	active site
717608001896	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
717608001897	selenocysteine synthase; Provisional; Region: PRK04311
717608001898	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
717608001899	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
717608001900	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608001901	catalytic residue [active]
717608001902	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
717608001903	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
717608001904	G1 box; other site
717608001905	putative GEF interaction site [polypeptide binding]; other site
717608001906	GTP/Mg2+ binding site [chemical binding]; other site
717608001907	Switch I region; other site
717608001908	G2 box; other site
717608001909	G3 box; other site
717608001910	Switch II region; other site
717608001911	G4 box; other site
717608001912	G5 box; other site
717608001913	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
717608001914	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
717608001915	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
717608001916	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
717608001917	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
717608001918	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
717608001919	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717608001920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608001921	catalytic residue [active]
717608001922	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
717608001923	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717608001924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608001925	Walker A motif; other site
717608001926	ATP binding site [chemical binding]; other site
717608001927	Walker B motif; other site
717608001928	arginine finger; other site
717608001929	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
717608001930	DNA-binding interface [nucleotide binding]; DNA binding site
717608001931	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
717608001932	classical (c) SDRs; Region: SDR_c; cd05233
717608001933	NAD(P) binding site [chemical binding]; other site
717608001934	active site
717608001935	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
717608001936	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
717608001937	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608001938	catalytic residue [active]
717608001939	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
717608001940	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717608001941	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717608001942	substrate binding pocket [chemical binding]; other site
717608001943	membrane-bound complex binding site; other site
717608001944	hinge residues; other site
717608001945	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
717608001946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608001947	dimer interface [polypeptide binding]; other site
717608001948	conserved gate region; other site
717608001949	putative PBP binding loops; other site
717608001950	ABC-ATPase subunit interface; other site
717608001951	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001952	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001953	active site
717608001954	DNA binding site [nucleotide binding]
717608001955	Int/Topo IB signature motif; other site
717608001956	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
717608001957	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001958	active site
717608001959	DNA binding site [nucleotide binding]
717608001960	Int/Topo IB signature motif; other site
717608001961	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608001962	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608001963	salt bridge; other site
717608001964	non-specific DNA binding site [nucleotide binding]; other site
717608001965	sequence-specific DNA binding site [nucleotide binding]; other site
717608001966	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608001967	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608001968	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
717608001969	YARHG domain; Region: YARHG; pfam13308
717608001970	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
717608001971	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
717608001972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608001973	S-adenosylmethionine binding site [chemical binding]; other site
717608001974	HsdM N-terminal domain; Region: HsdM_N; pfam12161
717608001975	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
717608001976	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717608001977	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
717608001978	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
717608001979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608001980	ATP binding site [chemical binding]; other site
717608001981	putative Mg++ binding site [ion binding]; other site
717608001982	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
717608001983	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
717608001984	putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900
717608001985	Domain of unknown function (DUF932); Region: DUF932; pfam06067
717608001986	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717608001987	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
717608001988	MPN+ (JAMM) motif; other site
717608001989	Zinc-binding site [ion binding]; other site
717608001990	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
717608001991	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608001992	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
717608001993	catalytic residues [active]
717608001994	catalytic nucleophile [active]
717608001995	Presynaptic Site I dimer interface [polypeptide binding]; other site
717608001996	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
717608001997	Synaptic Flat tetramer interface [polypeptide binding]; other site
717608001998	Synaptic Site I dimer interface [polypeptide binding]; other site
717608001999	DNA binding site [nucleotide binding]
717608002000	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
717608002001	AAA domain; Region: AAA_14; pfam13173
717608002002	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
717608002003	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
717608002004	AAA domain; Region: AAA_14; pfam13173
717608002005	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
717608002006	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
717608002007	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
717608002008	Flavin Reductases; Region: FlaRed; cl00801
717608002009	Predicted transcriptional regulators [Transcription]; Region: COG1733
717608002010	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
717608002011	4Fe-4S binding domain; Region: Fer4_6; pfam12837
717608002012	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717608002013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608002014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608002015	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608002016	dimerization interface [polypeptide binding]; other site
717608002017	aspartate aminotransferase; Provisional; Region: PRK05764
717608002018	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608002019	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608002020	homodimer interface [polypeptide binding]; other site
717608002021	catalytic residue [active]
717608002022	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
717608002023	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
717608002024	short chain dehydrogenase; Provisional; Region: PRK08339
717608002025	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
717608002026	putative NAD(P) binding site [chemical binding]; other site
717608002027	putative active site [active]
717608002028	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
717608002029	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
717608002030	active site
717608002031	catalytic residue [active]
717608002032	dimer interface [polypeptide binding]; other site
717608002033	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717608002034	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
717608002035	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
717608002036	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
717608002037	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608002038	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
717608002039	Soluble P-type ATPase [General function prediction only]; Region: COG4087
717608002040	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
717608002041	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
717608002042	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
717608002043	active site
717608002044	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608002045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608002046	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717608002047	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717608002048	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717608002049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002050	dimer interface [polypeptide binding]; other site
717608002051	conserved gate region; other site
717608002052	putative PBP binding loops; other site
717608002053	ABC-ATPase subunit interface; other site
717608002054	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717608002055	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717608002056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002057	dimer interface [polypeptide binding]; other site
717608002058	conserved gate region; other site
717608002059	putative PBP binding loops; other site
717608002060	ABC-ATPase subunit interface; other site
717608002061	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002062	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608002063	Walker A/P-loop; other site
717608002064	ATP binding site [chemical binding]; other site
717608002065	Q-loop/lid; other site
717608002066	ABC transporter signature motif; other site
717608002067	Walker B; other site
717608002068	D-loop; other site
717608002069	H-loop/switch region; other site
717608002070	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608002071	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608002072	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002073	Walker A/P-loop; other site
717608002074	ATP binding site [chemical binding]; other site
717608002075	Q-loop/lid; other site
717608002076	ABC transporter signature motif; other site
717608002077	Walker B; other site
717608002078	D-loop; other site
717608002079	H-loop/switch region; other site
717608002080	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608002081	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
717608002082	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
717608002083	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608002084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608002085	homodimer interface [polypeptide binding]; other site
717608002086	catalytic residue [active]
717608002087	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
717608002088	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608002089	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608002090	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
717608002091	iron binding site [ion binding]; other site
717608002092	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
717608002093	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608002094	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717608002095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
717608002096	Methyltransferase domain; Region: Methyltransf_23; pfam13489
717608002097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608002098	S-adenosylmethionine binding site [chemical binding]; other site
717608002099	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
717608002100	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
717608002101	putative dimer interface [polypeptide binding]; other site
717608002102	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
717608002103	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
717608002104	NAD-dependent deacetylase; Provisional; Region: PRK00481
717608002105	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
717608002106	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608002107	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
717608002108	active site
717608002109	catalytic tetrad [active]
717608002110	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
717608002111	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
717608002112	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
717608002113	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717608002114	ssDNA binding site [nucleotide binding]; other site
717608002115	dimer interface [polypeptide binding]; other site
717608002116	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717608002117	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
717608002118	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608002119	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608002120	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608002121	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
717608002122	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
717608002123	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
717608002124	DHH family; Region: DHH; pfam01368
717608002125	DHHA1 domain; Region: DHHA1; pfam02272
717608002126	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
717608002127	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
717608002128	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
717608002129	replicative DNA helicase; Region: DnaB; TIGR00665
717608002130	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
717608002131	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
717608002132	Walker A motif; other site
717608002133	ATP binding site [chemical binding]; other site
717608002134	Walker B motif; other site
717608002135	DNA binding loops [nucleotide binding]
717608002136	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
717608002137	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764
717608002138	DNA binding residues [nucleotide binding]
717608002139	V-type ATP synthase subunit I; Validated; Region: PRK05771
717608002140	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
717608002141	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
717608002142	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
717608002143	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
717608002144	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
717608002145	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
717608002146	V-type ATP synthase subunit A; Provisional; Region: PRK04192
717608002147	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717608002148	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
717608002149	Walker A motif/ATP binding site; other site
717608002150	Walker B motif; other site
717608002151	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717608002152	V-type ATP synthase subunit B; Provisional; Region: PRK04196
717608002153	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717608002154	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
717608002155	Walker A motif homologous position; other site
717608002156	Walker B motif; other site
717608002157	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717608002158	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
717608002159	Transcriptional regulators [Transcription]; Region: PurR; COG1609
717608002160	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
717608002161	DNA binding site [nucleotide binding]
717608002162	domain linker motif; other site
717608002163	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
717608002164	putative dimerization interface [polypeptide binding]; other site
717608002165	putative ligand binding site [chemical binding]; other site
717608002166	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
717608002167	HPr interaction site; other site
717608002168	glycerol kinase (GK) interaction site [polypeptide binding]; other site
717608002169	active site
717608002170	phosphorylation site [posttranslational modification]
717608002171	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
717608002172	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717608002173	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
717608002174	active site turn [active]
717608002175	phosphorylation site [posttranslational modification]
717608002176	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
717608002177	putative catalytic site [active]
717608002178	putative metal binding site [ion binding]; other site
717608002179	putative phosphate binding site [ion binding]; other site
717608002180	4-alpha-glucanotransferase; Provisional; Region: PRK14508
717608002181	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
717608002182	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
717608002183	catalytic residues [active]
717608002184	short chain dehydrogenase; Provisional; Region: PRK06940
717608002185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717608002186	NAD(P) binding site [chemical binding]; other site
717608002187	active site
717608002188	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
717608002189	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608002190	active site
717608002191	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
717608002192	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
717608002193	hinge; other site
717608002194	active site
717608002195	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608002196	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608002197	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608002198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608002199	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608002200	dimerization interface [polypeptide binding]; other site
717608002201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608002202	dimer interface [polypeptide binding]; other site
717608002203	phosphorylation site [posttranslational modification]
717608002204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608002205	ATP binding site [chemical binding]; other site
717608002206	Mg2+ binding site [ion binding]; other site
717608002207	G-X-G motif; other site
717608002208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608002209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002210	active site
717608002211	phosphorylation site [posttranslational modification]
717608002212	intermolecular recognition site; other site
717608002213	dimerization interface [polypeptide binding]; other site
717608002214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608002215	DNA binding site [nucleotide binding]
717608002216	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
717608002217	helicase 45; Provisional; Region: PTZ00424
717608002218	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
717608002219	ATP binding site [chemical binding]; other site
717608002220	Mg++ binding site [ion binding]; other site
717608002221	motif III; other site
717608002222	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608002223	nucleotide binding region [chemical binding]; other site
717608002224	ATP-binding site [chemical binding]; other site
717608002225	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
717608002226	RNA binding site [nucleotide binding]; other site
717608002227	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608002228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002229	active site
717608002230	phosphorylation site [posttranslational modification]
717608002231	intermolecular recognition site; other site
717608002232	dimerization interface [polypeptide binding]; other site
717608002233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608002234	DNA binding site [nucleotide binding]
717608002235	sensory histidine kinase CreC; Provisional; Region: PRK11100
717608002236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608002237	dimerization interface [polypeptide binding]; other site
717608002238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608002239	dimer interface [polypeptide binding]; other site
717608002240	phosphorylation site [posttranslational modification]
717608002241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608002242	ATP binding site [chemical binding]; other site
717608002243	Mg2+ binding site [ion binding]; other site
717608002244	G-X-G motif; other site
717608002245	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608002246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002247	active site
717608002248	phosphorylation site [posttranslational modification]
717608002249	intermolecular recognition site; other site
717608002250	dimerization interface [polypeptide binding]; other site
717608002251	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608002252	DNA binding site [nucleotide binding]
717608002253	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
717608002254	MutS domain III; Region: MutS_III; pfam05192
717608002255	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
717608002256	Walker A/P-loop; other site
717608002257	ATP binding site [chemical binding]; other site
717608002258	Q-loop/lid; other site
717608002259	ABC transporter signature motif; other site
717608002260	Walker B; other site
717608002261	D-loop; other site
717608002262	H-loop/switch region; other site
717608002263	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
717608002264	Smr domain; Region: Smr; pfam01713
717608002265	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
717608002266	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
717608002267	protein binding site [polypeptide binding]; other site
717608002268	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
717608002269	generic binding surface I; other site
717608002270	generic binding surface II; other site
717608002271	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608002272	Zn2+ binding site [ion binding]; other site
717608002273	Mg2+ binding site [ion binding]; other site
717608002274	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
717608002275	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
717608002276	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
717608002277	Catalytic site [active]
717608002278	glycogen branching enzyme; Provisional; Region: PRK05402
717608002279	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
717608002280	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
717608002281	active site
717608002282	catalytic site [active]
717608002283	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
717608002284	mechanosensitive channel MscS; Provisional; Region: PRK10334
717608002285	Mechanosensitive ion channel; Region: MS_channel; pfam00924
717608002286	HD domain; Region: HD_4; pfam13328
717608002287	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
717608002288	serine O-acetyltransferase; Region: cysE; TIGR01172
717608002289	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
717608002290	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
717608002291	trimer interface [polypeptide binding]; other site
717608002292	active site
717608002293	substrate binding site [chemical binding]; other site
717608002294	CoA binding site [chemical binding]; other site
717608002295	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
717608002296	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
717608002297	Ligand Binding Site [chemical binding]; other site
717608002298	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717608002299	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717608002300	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
717608002301	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
717608002302	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717608002303	AAA ATPase domain; Region: AAA_15; pfam13175
717608002304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608002305	Walker A/P-loop; other site
717608002306	ATP binding site [chemical binding]; other site
717608002307	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
717608002308	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
717608002309	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
717608002310	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717608002311	active site
717608002312	metal binding site [ion binding]; metal-binding site
717608002313	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
717608002314	putative active site [active]
717608002315	nucleotide binding site [chemical binding]; other site
717608002316	nudix motif; other site
717608002317	putative metal binding site [ion binding]; other site
717608002318	Protein of unknown function (DUF554); Region: DUF554; pfam04474
717608002319	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
717608002320	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
717608002321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608002322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608002323	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608002324	dimerization interface [polypeptide binding]; other site
717608002325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
717608002326	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
717608002327	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717608002328	metal ion-dependent adhesion site (MIDAS); other site
717608002329	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
717608002330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608002331	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
717608002332	Walker A motif; other site
717608002333	ATP binding site [chemical binding]; other site
717608002334	Walker B motif; other site
717608002335	arginine finger; other site
717608002336	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
717608002337	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
717608002338	active site
717608002339	metal binding site [ion binding]; metal-binding site
717608002340	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
717608002341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608002342	FeS/SAM binding site; other site
717608002343	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717608002344	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608002345	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608002346	DNA binding residues [nucleotide binding]
717608002347	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
717608002348	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
717608002349	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
717608002350	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717608002351	minor groove reading motif; other site
717608002352	helix-hairpin-helix signature motif; other site
717608002353	active site
717608002354	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717608002355	Predicted thioesterase [General function prediction only]; Region: COG5496
717608002356	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
717608002357	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
717608002358	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
717608002359	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
717608002360	dimer interface [polypeptide binding]; other site
717608002361	active site
717608002362	metal binding site [ion binding]; metal-binding site
717608002363	glutathione binding site [chemical binding]; other site
717608002364	dihydroorotase; Validated; Region: pyrC; PRK09357
717608002365	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608002366	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
717608002367	active site
717608002368	4-alpha-glucanotransferase; Provisional; Region: PRK14508
717608002369	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
717608002370	peroxiredoxin; Provisional; Region: PRK13189
717608002371	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
717608002372	dimer interface [polypeptide binding]; other site
717608002373	decamer (pentamer of dimers) interface [polypeptide binding]; other site
717608002374	catalytic triad [active]
717608002375	Uncharacterized conserved protein [Function unknown]; Region: COG2155
717608002376	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
717608002377	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608002378	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608002379	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608002380	dimerization interface [polypeptide binding]; other site
717608002381	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
717608002382	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
717608002383	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717608002384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002385	dimer interface [polypeptide binding]; other site
717608002386	conserved gate region; other site
717608002387	putative PBP binding loops; other site
717608002388	ABC-ATPase subunit interface; other site
717608002389	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
717608002390	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717608002391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002392	dimer interface [polypeptide binding]; other site
717608002393	conserved gate region; other site
717608002394	putative PBP binding loops; other site
717608002395	ABC-ATPase subunit interface; other site
717608002396	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608002397	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002398	Walker A/P-loop; other site
717608002399	ATP binding site [chemical binding]; other site
717608002400	Q-loop/lid; other site
717608002401	ABC transporter signature motif; other site
717608002402	Walker B; other site
717608002403	D-loop; other site
717608002404	H-loop/switch region; other site
717608002405	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608002406	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
717608002407	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002408	Walker A/P-loop; other site
717608002409	ATP binding site [chemical binding]; other site
717608002410	Q-loop/lid; other site
717608002411	ABC transporter signature motif; other site
717608002412	Walker B; other site
717608002413	D-loop; other site
717608002414	H-loop/switch region; other site
717608002415	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717608002416	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717608002417	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717608002418	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608002419	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717608002420	metal binding site [ion binding]; metal-binding site
717608002421	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717608002422	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
717608002423	DNA binding residues [nucleotide binding]
717608002424	putative dimer interface [polypeptide binding]; other site
717608002425	glycerate kinase; Region: TIGR00045
717608002426	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
717608002427	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717608002428	Walker A/P-loop; other site
717608002429	ATP binding site [chemical binding]; other site
717608002430	Q-loop/lid; other site
717608002431	ABC transporter signature motif; other site
717608002432	Walker B; other site
717608002433	D-loop; other site
717608002434	H-loop/switch region; other site
717608002435	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717608002436	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608002437	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717608002438	TM-ABC transporter signature motif; other site
717608002439	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608002440	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
717608002441	hypothetical protein; Provisional; Region: PRK02399
717608002442	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
717608002443	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
717608002444	hypothetical protein; Provisional; Region: PRK11770
717608002445	Domain of unknown function (DUF307); Region: DUF307; pfam03733
717608002446	Domain of unknown function (DUF307); Region: DUF307; pfam03733
717608002447	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717608002448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608002449	ABC transporter; Region: ABC_tran_2; pfam12848
717608002450	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608002451	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608002452	putative efflux protein, MATE family; Region: matE; TIGR00797
717608002453	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
717608002454	Clp amino terminal domain; Region: Clp_N; pfam02861
717608002455	Clp amino terminal domain; Region: Clp_N; pfam02861
717608002456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608002457	Walker A motif; other site
717608002458	ATP binding site [chemical binding]; other site
717608002459	Walker B motif; other site
717608002460	arginine finger; other site
717608002461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608002462	Walker A motif; other site
717608002463	ATP binding site [chemical binding]; other site
717608002464	Walker B motif; other site
717608002465	arginine finger; other site
717608002466	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
717608002467	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
717608002468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608002469	Walker A/P-loop; other site
717608002470	ATP binding site [chemical binding]; other site
717608002471	Q-loop/lid; other site
717608002472	ABC transporter signature motif; other site
717608002473	Walker B; other site
717608002474	D-loop; other site
717608002475	H-loop/switch region; other site
717608002476	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
717608002477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002478	dimer interface [polypeptide binding]; other site
717608002479	conserved gate region; other site
717608002480	putative PBP binding loops; other site
717608002481	ABC-ATPase subunit interface; other site
717608002482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002483	dimer interface [polypeptide binding]; other site
717608002484	conserved gate region; other site
717608002485	putative PBP binding loops; other site
717608002486	ABC-ATPase subunit interface; other site
717608002487	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717608002488	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717608002489	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717608002490	2-isopropylmalate synthase; Validated; Region: PRK03739
717608002491	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
717608002492	active site
717608002493	catalytic residues [active]
717608002494	metal binding site [ion binding]; metal-binding site
717608002495	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
717608002496	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
717608002497	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
717608002498	UDP-galactopyranose mutase; Region: GLF; pfam03275
717608002499	LicD family; Region: LicD; cl01378
717608002500	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
717608002501	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
717608002502	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
717608002503	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608002504	catalytic residue [active]
717608002505	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
717608002506	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
717608002507	active site
717608002508	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
717608002509	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
717608002510	active site
717608002511	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
717608002512	Ligand binding site; other site
717608002513	Putative Catalytic site; other site
717608002514	DXD motif; other site
717608002515	Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066
717608002516	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
717608002517	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
717608002518	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
717608002519	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608002520	Coenzyme A binding pocket [chemical binding]; other site
717608002521	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717608002522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002523	dimer interface [polypeptide binding]; other site
717608002524	conserved gate region; other site
717608002525	putative PBP binding loops; other site
717608002526	ABC-ATPase subunit interface; other site
717608002527	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
717608002528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002529	dimer interface [polypeptide binding]; other site
717608002530	conserved gate region; other site
717608002531	putative PBP binding loops; other site
717608002532	ABC-ATPase subunit interface; other site
717608002533	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002534	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
717608002535	Walker A/P-loop; other site
717608002536	ATP binding site [chemical binding]; other site
717608002537	Q-loop/lid; other site
717608002538	ABC transporter signature motif; other site
717608002539	Walker B; other site
717608002540	D-loop; other site
717608002541	H-loop/switch region; other site
717608002542	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717608002543	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608002544	Walker A/P-loop; other site
717608002545	ATP binding site [chemical binding]; other site
717608002546	Q-loop/lid; other site
717608002547	ABC transporter signature motif; other site
717608002548	Walker B; other site
717608002549	D-loop; other site
717608002550	H-loop/switch region; other site
717608002551	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
717608002552	AIR carboxylase; Region: AIRC; smart01001
717608002553	Protein of unknown function DUF111; Region: DUF111; pfam01969
717608002554	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
717608002555	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717608002556	FMN binding site [chemical binding]; other site
717608002557	dimer interface [polypeptide binding]; other site
717608002558	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
717608002559	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
717608002560	active site
717608002561	Acylphosphatase; Region: Acylphosphatase; pfam00708
717608002562	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
717608002563	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
717608002564	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
717608002565	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
717608002566	putative active site [active]
717608002567	putative CoA binding site [chemical binding]; other site
717608002568	nudix motif; other site
717608002569	metal binding site [ion binding]; metal-binding site
717608002570	Acylphosphatase; Region: Acylphosphatase; pfam00708
717608002571	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
717608002572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717608002573	putative substrate translocation pore; other site
717608002574	Cupin domain; Region: Cupin_2; pfam07883
717608002575	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608002576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608002577	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
717608002578	XdhC Rossmann domain; Region: XdhC_C; pfam13478
717608002579	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
717608002580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608002581	Walker A/P-loop; other site
717608002582	ATP binding site [chemical binding]; other site
717608002583	Q-loop/lid; other site
717608002584	ABC transporter signature motif; other site
717608002585	Walker B; other site
717608002586	D-loop; other site
717608002587	H-loop/switch region; other site
717608002588	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
717608002589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608002590	dimer interface [polypeptide binding]; other site
717608002591	conserved gate region; other site
717608002592	putative PBP binding loops; other site
717608002593	ABC-ATPase subunit interface; other site
717608002594	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
717608002595	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717608002596	MOSC domain; Region: MOSC; pfam03473
717608002597	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
717608002598	MPT binding site; other site
717608002599	trimer interface [polypeptide binding]; other site
717608002600	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
717608002601	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608002602	FeS/SAM binding site; other site
717608002603	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
717608002604	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
717608002605	trimer interface [polypeptide binding]; other site
717608002606	dimer interface [polypeptide binding]; other site
717608002607	putative active site [active]
717608002608	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
717608002609	putative MPT binding site; other site
717608002610	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
717608002611	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
717608002612	prolyl-tRNA synthetase; Provisional; Region: PRK08661
717608002613	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
717608002614	dimer interface [polypeptide binding]; other site
717608002615	motif 1; other site
717608002616	active site
717608002617	motif 2; other site
717608002618	motif 3; other site
717608002619	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
717608002620	anticodon binding site; other site
717608002621	zinc-binding site [ion binding]; other site
717608002622	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
717608002623	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
717608002624	active site
717608002625	NTP binding site [chemical binding]; other site
717608002626	metal binding triad [ion binding]; metal-binding site
717608002627	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
717608002628	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
717608002629	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
717608002630	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
717608002631	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717608002632	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608002633	catalytic residue [active]
717608002634	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
717608002635	spermidine synthase; Provisional; Region: PRK00811
717608002636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608002637	S-adenosylmethionine binding site [chemical binding]; other site
717608002638	agmatinase; Region: agmatinase; TIGR01230
717608002639	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
717608002640	putative active site [active]
717608002641	Mn binding site [ion binding]; other site
717608002642	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
717608002643	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
717608002644	NAD(P) binding pocket [chemical binding]; other site
717608002645	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
717608002646	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
717608002647	dimer interface [polypeptide binding]; other site
717608002648	active site
717608002649	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
717608002650	catalytic residues [active]
717608002651	substrate binding site [chemical binding]; other site
717608002652	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
717608002653	active site
717608002654	dimer interfaces [polypeptide binding]; other site
717608002655	catalytic residues [active]
717608002656	transcription termination factor Rho; Provisional; Region: PRK12678
717608002657	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
717608002658	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
717608002659	RNA binding site [nucleotide binding]; other site
717608002660	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608002661	Walker A motif; other site
717608002662	ATP binding site [chemical binding]; other site
717608002663	Walker B motif; other site
717608002664	aspartate aminotransferase; Provisional; Region: PRK05764
717608002665	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608002666	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608002667	homodimer interface [polypeptide binding]; other site
717608002668	catalytic residue [active]
717608002669	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
717608002670	Class I aldolases; Region: Aldolase_Class_I; cl17187
717608002671	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717608002672	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
717608002673	substrate binding site [chemical binding]; other site
717608002674	ATP binding site [chemical binding]; other site
717608002675	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
717608002676	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
717608002677	NAD(P) binding site [chemical binding]; other site
717608002678	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
717608002679	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
717608002680	NADP binding site [chemical binding]; other site
717608002681	homodimer interface [polypeptide binding]; other site
717608002682	active site
717608002683	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
717608002684	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
717608002685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608002686	S-adenosylmethionine binding site [chemical binding]; other site
717608002687	peptide chain release factor 1; Validated; Region: prfA; PRK00591
717608002688	This domain is found in peptide chain release factors; Region: PCRF; smart00937
717608002689	RF-1 domain; Region: RF-1; pfam00472
717608002690	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
717608002691	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
717608002692	Glycoprotease family; Region: Peptidase_M22; pfam00814
717608002693	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
717608002694	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608002695	Coenzyme A binding pocket [chemical binding]; other site
717608002696	ribonuclease Z; Reviewed; Region: PRK00055
717608002697	UGMP family protein; Validated; Region: PRK09604
717608002698	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
717608002699	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
717608002700	substrate binding site; other site
717608002701	dimer interface; other site
717608002702	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
717608002703	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
717608002704	putative ligand binding site [chemical binding]; other site
717608002705	putative NAD binding site [chemical binding]; other site
717608002706	catalytic site [active]
717608002707	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
717608002708	S17 interaction site [polypeptide binding]; other site
717608002709	S8 interaction site; other site
717608002710	16S rRNA interaction site [nucleotide binding]; other site
717608002711	streptomycin interaction site [chemical binding]; other site
717608002712	23S rRNA interaction site [nucleotide binding]; other site
717608002713	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
717608002714	elongation factor Tu; Reviewed; Region: PRK00049
717608002715	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
717608002716	G1 box; other site
717608002717	GEF interaction site [polypeptide binding]; other site
717608002718	GTP/Mg2+ binding site [chemical binding]; other site
717608002719	Switch I region; other site
717608002720	G2 box; other site
717608002721	G3 box; other site
717608002722	Switch II region; other site
717608002723	G4 box; other site
717608002724	G5 box; other site
717608002725	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
717608002726	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
717608002727	Antibiotic Binding Site [chemical binding]; other site
717608002728	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608002729	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608002730	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717608002731	MarR family; Region: MarR; pfam01047
717608002732	Uncharacterized conserved protein [Function unknown]; Region: COG4279
717608002733	MoxR-like ATPases [General function prediction only]; Region: COG0714
717608002734	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
717608002735	SKIP/SNW domain; Region: SKIP_SNW; pfam02731
717608002736	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
717608002737	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
717608002738	metal ion-dependent adhesion site (MIDAS); other site
717608002739	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
717608002740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608002741	S-adenosylmethionine binding site [chemical binding]; other site
717608002742	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
717608002743	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
717608002744	active site
717608002745	substrate binding site [chemical binding]; other site
717608002746	trimer interface [polypeptide binding]; other site
717608002747	CoA binding site [chemical binding]; other site
717608002748	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
717608002749	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
717608002750	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
717608002751	putative active site [active]
717608002752	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
717608002753	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
717608002754	active site turn [active]
717608002755	phosphorylation site [posttranslational modification]
717608002756	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717608002757	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
717608002758	HPr interaction site; other site
717608002759	glycerol kinase (GK) interaction site [polypeptide binding]; other site
717608002760	active site
717608002761	phosphorylation site [posttranslational modification]
717608002762	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
717608002763	beta-galactosidase; Region: BGL; TIGR03356
717608002764	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
717608002765	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608002766	Coenzyme A binding pocket [chemical binding]; other site
717608002767	S-ribosylhomocysteinase; Provisional; Region: PRK02260
717608002768	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608002769	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717608002770	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608002771	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
717608002772	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
717608002773	Ligand binding site; other site
717608002774	Putative Catalytic site; other site
717608002775	DXD motif; other site
717608002776	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
717608002777	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
717608002778	active site
717608002779	HIGH motif; other site
717608002780	dimer interface [polypeptide binding]; other site
717608002781	KMSKS motif; other site
717608002782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608002783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608002784	dimer interface [polypeptide binding]; other site
717608002785	phosphorylation site [posttranslational modification]
717608002786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608002787	ATP binding site [chemical binding]; other site
717608002788	Mg2+ binding site [ion binding]; other site
717608002789	G-X-G motif; other site
717608002790	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608002791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002792	active site
717608002793	phosphorylation site [posttranslational modification]
717608002794	intermolecular recognition site; other site
717608002795	dimerization interface [polypeptide binding]; other site
717608002796	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608002797	DNA binding site [nucleotide binding]
717608002798	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
717608002799	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
717608002800	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
717608002801	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
717608002802	active pocket/dimerization site; other site
717608002803	active site
717608002804	phosphorylation site [posttranslational modification]
717608002805	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
717608002806	Rubredoxin; Region: Rubredoxin; pfam00301
717608002807	iron binding site [ion binding]; other site
717608002808	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
717608002809	Rubrerythrin [Energy production and conversion]; Region: COG1592
717608002810	diiron binding motif [ion binding]; other site
717608002811	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
717608002812	metal binding site 2 [ion binding]; metal-binding site
717608002813	putative DNA binding helix; other site
717608002814	metal binding site 1 [ion binding]; metal-binding site
717608002815	dimer interface [polypeptide binding]; other site
717608002816	structural Zn2+ binding site [ion binding]; other site
717608002817	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
717608002818	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608002819	active site
717608002820	nucleotide binding site [chemical binding]; other site
717608002821	HIGH motif; other site
717608002822	KMSKS motif; other site
717608002823	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
717608002824	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
717608002825	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608002826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608002827	ATP binding site [chemical binding]; other site
717608002828	Mg2+ binding site [ion binding]; other site
717608002829	G-X-G motif; other site
717608002830	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717608002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002832	active site
717608002833	phosphorylation site [posttranslational modification]
717608002834	intermolecular recognition site; other site
717608002835	dimerization interface [polypeptide binding]; other site
717608002836	YcbB domain; Region: YcbB; pfam08664
717608002837	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608002838	glutamate dehydrogenase; Provisional; Region: PRK09414
717608002839	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
717608002840	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
717608002841	NAD(P) binding site [chemical binding]; other site
717608002842	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
717608002843	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
717608002844	putative ligand binding site [chemical binding]; other site
717608002845	NAD binding site [chemical binding]; other site
717608002846	dimerization interface [polypeptide binding]; other site
717608002847	catalytic site [active]
717608002848	putative hydrolase; Validated; Region: PRK09248
717608002849	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
717608002850	active site
717608002851	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
717608002852	RNA binding site [nucleotide binding]; other site
717608002853	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
717608002854	RNA binding site [nucleotide binding]; other site
717608002855	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
717608002856	RNA binding site [nucleotide binding]; other site
717608002857	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717608002858	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
717608002859	synthetase active site [active]
717608002860	NTP binding site [chemical binding]; other site
717608002861	metal binding site [ion binding]; metal-binding site
717608002862	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
717608002863	putative active site [active]
717608002864	dimerization interface [polypeptide binding]; other site
717608002865	putative tRNAtyr binding site [nucleotide binding]; other site
717608002866	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
717608002867	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
717608002868	oligomer interface [polypeptide binding]; other site
717608002869	putative active site [active]
717608002870	metal binding site [ion binding]; metal-binding site
717608002871	trigger factor; Provisional; Region: tig; PRK01490
717608002872	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
717608002873	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
717608002874	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608002875	active site
717608002876	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
717608002877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608002878	active site
717608002879	motif I; other site
717608002880	motif II; other site
717608002881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608002882	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
717608002883	active site
717608002884	imidazolonepropionase; Validated; Region: PRK09356
717608002885	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
717608002886	active site
717608002887	urocanate hydratase; Provisional; Region: PRK05414
717608002888	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
717608002889	Predicted ATPase [General function prediction only]; Region: COG3899
717608002890	AAA ATPase domain; Region: AAA_16; pfam13191
717608002891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
717608002892	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608002893	binding surface
717608002894	TPR motif; other site
717608002895	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
717608002896	active sites [active]
717608002897	tetramer interface [polypeptide binding]; other site
717608002898	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
717608002899	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
717608002900	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
717608002901	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
717608002902	Asp23 family; Region: Asp23; pfam03780
717608002903	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
717608002904	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
717608002905	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
717608002906	Predicted membrane protein [Function unknown]; Region: COG3601
717608002907	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
717608002908	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717608002909	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608002910	transcription antitermination factor NusB; Region: nusB; TIGR01951
717608002911	putative RNA binding site [nucleotide binding]; other site
717608002912	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
717608002913	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
717608002914	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
717608002915	substrate binding pocket [chemical binding]; other site
717608002916	chain length determination region; other site
717608002917	substrate-Mg2+ binding site; other site
717608002918	catalytic residues [active]
717608002919	aspartate-rich region 1; other site
717608002920	active site lid residues [active]
717608002921	aspartate-rich region 2; other site
717608002922	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
717608002923	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608002924	RNA binding surface [nucleotide binding]; other site
717608002925	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
717608002926	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
717608002927	ATP-NAD kinase; Region: NAD_kinase; pfam01513
717608002928	arginine repressor; Provisional; Region: argR; PRK00441
717608002929	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
717608002930	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
717608002931	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
717608002932	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
717608002933	Walker A/P-loop; other site
717608002934	ATP binding site [chemical binding]; other site
717608002935	Q-loop/lid; other site
717608002936	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
717608002937	ABC transporter signature motif; other site
717608002938	Walker B; other site
717608002939	D-loop; other site
717608002940	H-loop/switch region; other site
717608002941	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608002942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608002943	active site
717608002944	phosphorylation site [posttranslational modification]
717608002945	intermolecular recognition site; other site
717608002946	dimerization interface [polypeptide binding]; other site
717608002947	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608002948	DNA binding site [nucleotide binding]
717608002949	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608002950	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608002951	dimerization interface [polypeptide binding]; other site
717608002952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608002953	dimer interface [polypeptide binding]; other site
717608002954	phosphorylation site [posttranslational modification]
717608002955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608002956	ATP binding site [chemical binding]; other site
717608002957	Mg2+ binding site [ion binding]; other site
717608002958	G-X-G motif; other site
717608002959	Hemerythrin; Region: Hemerythrin; cd12107
717608002960	Fe binding site [ion binding]; other site
717608002961	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
717608002962	active site
717608002963	metal binding site [ion binding]; metal-binding site
717608002964	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
717608002965	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
717608002966	transmembrane helices; other site
717608002967	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
717608002968	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
717608002969	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
717608002970	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
717608002971	inhibitor site; inhibition site
717608002972	active site
717608002973	dimer interface [polypeptide binding]; other site
717608002974	catalytic residue [active]
717608002975	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
717608002976	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
717608002977	putative active site [active]
717608002978	metal binding site [ion binding]; metal-binding site
717608002979	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
717608002980	BNR repeat-like domain; Region: BNR_2; pfam13088
717608002981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
717608002982	Propionate catabolism activator; Region: PrpR_N; pfam06506
717608002983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
717608002984	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
717608002985	Stage III sporulation protein D; Region: SpoIIID; pfam12116
717608002986	PrcB C-terminal; Region: PrcB_C; pfam14343
717608002987	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
717608002988	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
717608002989	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
717608002990	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
717608002991	Sel1-like repeats; Region: SEL1; smart00671
717608002992	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
717608002993	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
717608002994	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
717608002995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608002996	catalytic residue [active]
717608002997	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
717608002998	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
717608002999	intersubunit interface [polypeptide binding]; other site
717608003000	active site
717608003001	zinc binding site [ion binding]; other site
717608003002	Na+ binding site [ion binding]; other site
717608003003	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
717608003004	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
717608003005	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
717608003006	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
717608003007	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
717608003008	active site
717608003009	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608003010	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608003011	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608003012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717608003013	H+ Antiporter protein; Region: 2A0121; TIGR00900
717608003014	putative substrate translocation pore; other site
717608003015	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608003016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608003017	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717608003018	Methyltransferase domain; Region: Methyltransf_31; pfam13847
717608003019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608003020	S-adenosylmethionine binding site [chemical binding]; other site
717608003021	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608003022	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608003023	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608003024	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
717608003025	Phosphate transporter family; Region: PHO4; pfam01384
717608003026	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
717608003027	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
717608003028	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
717608003029	ATP binding site [chemical binding]; other site
717608003030	active site
717608003031	substrate binding site [chemical binding]; other site
717608003032	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
717608003033	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
717608003034	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
717608003035	putative RNA binding site [nucleotide binding]; other site
717608003036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608003037	S-adenosylmethionine binding site [chemical binding]; other site
717608003038	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
717608003039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608003040	Walker A motif; other site
717608003041	ATP binding site [chemical binding]; other site
717608003042	Walker B motif; other site
717608003043	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717608003044	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
717608003045	active site
717608003046	catalytic triad [active]
717608003047	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
717608003048	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
717608003049	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
717608003050	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
717608003051	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
717608003052	Protein export membrane protein; Region: SecD_SecF; pfam02355
717608003053	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
717608003054	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
717608003055	Preprotein translocase subunit; Region: YajC; pfam02699
717608003056	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
717608003057	tartrate dehydrogenase; Region: TTC; TIGR02089
717608003058	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
717608003059	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
717608003060	PYR/PP interface [polypeptide binding]; other site
717608003061	dimer interface [polypeptide binding]; other site
717608003062	TPP binding site [chemical binding]; other site
717608003063	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
717608003064	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
717608003065	TPP-binding site [chemical binding]; other site
717608003066	dimer interface [polypeptide binding]; other site
717608003067	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
717608003068	homodimer interface [polypeptide binding]; other site
717608003069	substrate-cofactor binding pocket; other site
717608003070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608003071	catalytic residue [active]
717608003072	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
717608003073	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
717608003074	putative ligand binding site [chemical binding]; other site
717608003075	putative NAD binding site [chemical binding]; other site
717608003076	putative catalytic site [active]
717608003077	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
717608003078	L-serine binding site [chemical binding]; other site
717608003079	ACT domain interface; other site
717608003080	xanthine permease; Region: pbuX; TIGR03173
717608003081	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
717608003082	CoenzymeA binding site [chemical binding]; other site
717608003083	subunit interaction site [polypeptide binding]; other site
717608003084	PHB binding site; other site
717608003085	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
717608003086	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
717608003087	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608003088	Coenzyme A binding pocket [chemical binding]; other site
717608003089	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
717608003090	putative active site [active]
717608003091	catalytic residue [active]
717608003092	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
717608003093	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
717608003094	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
717608003095	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608003096	ATP binding site [chemical binding]; other site
717608003097	putative Mg++ binding site [ion binding]; other site
717608003098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608003099	nucleotide binding region [chemical binding]; other site
717608003100	ATP-binding site [chemical binding]; other site
717608003101	TRCF domain; Region: TRCF; pfam03461
717608003102	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
717608003103	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608003104	RNA binding surface [nucleotide binding]; other site
717608003105	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
717608003106	probable active site [active]
717608003107	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717608003108	FMN binding site [chemical binding]; other site
717608003109	dimer interface [polypeptide binding]; other site
717608003110	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
717608003111	HTH domain; Region: HTH_11; pfam08279
717608003112	PRD domain; Region: PRD; pfam00874
717608003113	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
717608003114	active site
717608003115	P-loop; other site
717608003116	phosphorylation site [posttranslational modification]
717608003117	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
717608003118	putative deacylase active site [active]
717608003119	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
717608003120	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717608003121	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
717608003122	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
717608003123	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
717608003124	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608003125	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608003126	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
717608003127	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608003128	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
717608003129	active site
717608003130	DNA binding site [nucleotide binding]
717608003131	Int/Topo IB signature motif; other site
717608003132	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608003133	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
717608003134	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608003135	HsdM N-terminal domain; Region: HsdM_N; pfam12161
717608003136	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
717608003137	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717608003138	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
717608003139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608003140	S-adenosylmethionine binding site [chemical binding]; other site
717608003141	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
717608003142	active site
717608003143	catalytic motif [active]
717608003144	Zn binding site [ion binding]; other site
717608003145	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
717608003146	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
717608003147	ligand binding site [chemical binding]; other site
717608003148	flexible hinge region; other site
717608003149	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
717608003150	hybrid cluster protein; Provisional; Region: PRK05290
717608003151	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608003152	ACS interaction site; other site
717608003153	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
717608003154	hybrid metal cluster; other site
717608003155	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
717608003156	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
717608003157	Part of AAA domain; Region: AAA_19; pfam13245
717608003158	Family description; Region: UvrD_C_2; pfam13538
717608003159	Maf-like protein; Region: Maf; pfam02545
717608003160	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
717608003161	active site
717608003162	dimer interface [polypeptide binding]; other site
717608003163	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
717608003164	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717608003165	active site
717608003166	motif I; other site
717608003167	motif II; other site
717608003168	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608003169	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
717608003170	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
717608003171	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
717608003172	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
717608003173	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
717608003174	active site
717608003175	metal binding site [ion binding]; metal-binding site
717608003176	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
717608003177	active site
717608003178	Zn binding site [ion binding]; other site
717608003179	heat shock protein 90; Provisional; Region: PRK05218
717608003180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608003181	ATP binding site [chemical binding]; other site
717608003182	Mg2+ binding site [ion binding]; other site
717608003183	G-X-G motif; other site
717608003184	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717608003185	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
717608003186	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
717608003187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608003188	dimer interface [polypeptide binding]; other site
717608003189	conserved gate region; other site
717608003190	putative PBP binding loops; other site
717608003191	ABC-ATPase subunit interface; other site
717608003192	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608003193	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608003194	Walker A/P-loop; other site
717608003195	ATP binding site [chemical binding]; other site
717608003196	Q-loop/lid; other site
717608003197	ABC transporter signature motif; other site
717608003198	Walker B; other site
717608003199	D-loop; other site
717608003200	H-loop/switch region; other site
717608003201	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717608003202	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
717608003203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608003204	Walker A/P-loop; other site
717608003205	ATP binding site [chemical binding]; other site
717608003206	Q-loop/lid; other site
717608003207	ABC transporter signature motif; other site
717608003208	Walker B; other site
717608003209	D-loop; other site
717608003210	H-loop/switch region; other site
717608003211	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608003212	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717608003213	CAAX protease self-immunity; Region: Abi; pfam02517
717608003214	EDD domain protein, DegV family; Region: DegV; TIGR00762
717608003215	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717608003216	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
717608003217	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
717608003218	putative active site [active]
717608003219	putative metal binding site [ion binding]; other site
717608003220	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
717608003221	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
717608003222	A new structural DNA glycosylase; Region: AlkD_like; cd06561
717608003223	active site
717608003224	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608003225	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
717608003226	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608003227	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
717608003228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
717608003229	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
717608003230	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
717608003231	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
717608003232	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
717608003233	active site
717608003234	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
717608003235	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
717608003236	S1 domain; Region: S1_2; pfam13509
717608003237	S1 domain; Region: S1_2; pfam13509
717608003238	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
717608003239	RNA binding site [nucleotide binding]; other site
717608003240	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
717608003241	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
717608003242	homotrimer interaction site [polypeptide binding]; other site
717608003243	putative active site [active]
717608003244	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
717608003245	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
717608003246	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
717608003247	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
717608003248	glycerol kinase; Provisional; Region: glpK; PRK00047
717608003249	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
717608003250	N- and C-terminal domain interface [polypeptide binding]; other site
717608003251	active site
717608003252	MgATP binding site [chemical binding]; other site
717608003253	catalytic site [active]
717608003254	metal binding site [ion binding]; metal-binding site
717608003255	glycerol binding site [chemical binding]; other site
717608003256	homotetramer interface [polypeptide binding]; other site
717608003257	homodimer interface [polypeptide binding]; other site
717608003258	FBP binding site [chemical binding]; other site
717608003259	protein IIAGlc interface [polypeptide binding]; other site
717608003260	Predicted dehydrogenase [General function prediction only]; Region: COG0579
717608003261	hydroxyglutarate oxidase; Provisional; Region: PRK11728
717608003262	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
717608003263	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
717608003264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608003265	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717608003266	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
717608003267	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
717608003268	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
717608003269	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
717608003270	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608003271	catalytic residue [active]
717608003272	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
717608003273	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
717608003274	trimerization site [polypeptide binding]; other site
717608003275	active site
717608003276	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
717608003277	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
717608003278	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608003279	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
717608003280	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717608003281	active site
717608003282	metal binding site [ion binding]; metal-binding site
717608003283	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
717608003284	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
717608003285	Int/Topo IB signature motif; other site
717608003286	Domain of unknown function (DUF955); Region: DUF955; cl01076
717608003287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608003288	non-specific DNA binding site [nucleotide binding]; other site
717608003289	salt bridge; other site
717608003290	sequence-specific DNA binding site [nucleotide binding]; other site
717608003291	Helix-turn-helix domain; Region: HTH_17; cl17695
717608003292	Domain of unknown function (DUF955); Region: DUF955; pfam06114
717608003293	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608003294	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
717608003295	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608003296	DNA binding residues [nucleotide binding]
717608003297	VanZ like family; Region: VanZ; pfam04892
717608003298	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717608003299	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608003300	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608003301	DNA binding residues [nucleotide binding]
717608003302	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
717608003303	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
717608003304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608003305	Walker A/P-loop; other site
717608003306	ATP binding site [chemical binding]; other site
717608003307	Q-loop/lid; other site
717608003308	ABC transporter signature motif; other site
717608003309	Walker B; other site
717608003310	D-loop; other site
717608003311	H-loop/switch region; other site
717608003312	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
717608003313	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
717608003314	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
717608003315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608003316	Walker A/P-loop; other site
717608003317	ATP binding site [chemical binding]; other site
717608003318	Q-loop/lid; other site
717608003319	ABC transporter signature motif; other site
717608003320	Walker B; other site
717608003321	D-loop; other site
717608003322	H-loop/switch region; other site
717608003323	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
717608003324	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
717608003325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
717608003326	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
717608003327	Peptidase family M23; Region: Peptidase_M23; pfam01551
717608003328	C-terminal peptidase (prc); Region: prc; TIGR00225
717608003329	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
717608003330	protein binding site [polypeptide binding]; other site
717608003331	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
717608003332	Catalytic dyad [active]
717608003333	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
717608003334	excinuclease ABC subunit B; Provisional; Region: PRK05298
717608003335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608003336	ATP binding site [chemical binding]; other site
717608003337	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608003338	nucleotide binding region [chemical binding]; other site
717608003339	ATP-binding site [chemical binding]; other site
717608003340	Ultra-violet resistance protein B; Region: UvrB; pfam12344
717608003341	UvrB/uvrC motif; Region: UVR; pfam02151
717608003342	FeoA domain; Region: FeoA; cl00838
717608003343	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
717608003344	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
717608003345	Radical SAM superfamily; Region: Radical_SAM; pfam04055
717608003346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608003347	FeS/SAM binding site; other site
717608003348	AzlC protein; Region: AzlC; cl00570
717608003349	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
717608003350	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
717608003351	putative active site [active]
717608003352	FtsH Extracellular; Region: FtsH_ext; pfam06480
717608003353	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
717608003354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608003355	Walker A motif; other site
717608003356	ATP binding site [chemical binding]; other site
717608003357	Walker B motif; other site
717608003358	arginine finger; other site
717608003359	Peptidase family M41; Region: Peptidase_M41; pfam01434
717608003360	hypothetical protein; Provisional; Region: PRK13663
717608003361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
717608003362	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
717608003363	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
717608003364	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
717608003365	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
717608003366	GIY-YIG motif/motif A; other site
717608003367	active site
717608003368	catalytic site [active]
717608003369	putative DNA binding site [nucleotide binding]; other site
717608003370	metal binding site [ion binding]; metal-binding site
717608003371	UvrB/uvrC motif; Region: UVR; pfam02151
717608003372	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
717608003373	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
717608003374	FAD binding domain; Region: FAD_binding_4; pfam01565
717608003375	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
717608003376	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
717608003377	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717608003378	dimerization domain swap beta strand [polypeptide binding]; other site
717608003379	regulatory protein interface [polypeptide binding]; other site
717608003380	active site
717608003381	regulatory phosphorylation site [posttranslational modification]; other site
717608003382	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
717608003383	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
717608003384	active site
717608003385	PHP Thumb interface [polypeptide binding]; other site
717608003386	metal binding site [ion binding]; metal-binding site
717608003387	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
717608003388	generic binding surface II; other site
717608003389	generic binding surface I; other site
717608003390	6-phosphofructokinase; Provisional; Region: PRK03202
717608003391	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717608003392	active site
717608003393	ADP/pyrophosphate binding site [chemical binding]; other site
717608003394	dimerization interface [polypeptide binding]; other site
717608003395	allosteric effector site; other site
717608003396	fructose-1,6-bisphosphate binding site; other site
717608003397	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
717608003398	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
717608003399	FMN binding site [chemical binding]; other site
717608003400	active site
717608003401	catalytic residues [active]
717608003402	substrate binding site [chemical binding]; other site
717608003403	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
717608003404	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
717608003405	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
717608003406	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608003407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608003408	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608003409	dimerization interface [polypeptide binding]; other site
717608003410	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
717608003411	putative substrate binding region [chemical binding]; other site
717608003412	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608003413	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717608003414	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608003415	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
717608003416	active site
717608003417	catalytic tetrad [active]
717608003418	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
717608003419	catalytic site [active]
717608003420	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
717608003421	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
717608003422	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
717608003423	Propionate catabolism activator; Region: PrpR_N; pfam06506
717608003424	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
717608003425	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608003426	Walker A motif; other site
717608003427	ATP binding site [chemical binding]; other site
717608003428	Walker B motif; other site
717608003429	arginine finger; other site
717608003430	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717608003431	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
717608003432	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
717608003433	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
717608003434	ligand binding site [chemical binding]; other site
717608003435	NAD binding site [chemical binding]; other site
717608003436	dimerization interface [polypeptide binding]; other site
717608003437	catalytic site [active]
717608003438	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
717608003439	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
717608003440	DctM-like transporters; Region: DctM; pfam06808
717608003441	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
717608003442	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608003443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
717608003444	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
717608003445	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
717608003446	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608003447	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
717608003448	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
717608003449	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
717608003450	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717608003451	NAD binding site [chemical binding]; other site
717608003452	dimer interface [polypeptide binding]; other site
717608003453	substrate binding site [chemical binding]; other site
717608003454	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
717608003455	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608003456	active site
717608003457	HIGH motif; other site
717608003458	nucleotide binding site [chemical binding]; other site
717608003459	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608003460	active site
717608003461	KMSKS motif; other site
717608003462	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
717608003463	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717608003464	carboxyltransferase (CT) interaction site; other site
717608003465	biotinylation site [posttranslational modification]; other site
717608003466	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717608003467	carboxyltransferase (CT) interaction site; other site
717608003468	biotinylation site [posttranslational modification]; other site
717608003469	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717608003470	carboxyltransferase (CT) interaction site; other site
717608003471	biotinylation site [posttranslational modification]; other site
717608003472	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
717608003473	Coenzyme A transferase; Region: CoA_trans; cl17247
717608003474	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
717608003475	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
717608003476	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
717608003477	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
717608003478	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
717608003479	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
717608003480	Transcriptional regulator [Transcription]; Region: IclR; COG1414
717608003481	Bacterial transcriptional regulator; Region: IclR; pfam01614
717608003482	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
717608003483	oligomerisation interface [polypeptide binding]; other site
717608003484	mobile loop; other site
717608003485	roof hairpin; other site
717608003486	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
717608003487	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
717608003488	ring oligomerisation interface [polypeptide binding]; other site
717608003489	ATP/Mg binding site [chemical binding]; other site
717608003490	stacking interactions; other site
717608003491	hinge regions; other site
717608003492	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
717608003493	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
717608003494	active site
717608003495	PHP-associated; Region: PHP_C; pfam13263
717608003496	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717608003497	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
717608003498	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
717608003499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608003500	dimer interface [polypeptide binding]; other site
717608003501	conserved gate region; other site
717608003502	putative PBP binding loops; other site
717608003503	ABC-ATPase subunit interface; other site
717608003504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608003505	dimer interface [polypeptide binding]; other site
717608003506	conserved gate region; other site
717608003507	putative PBP binding loops; other site
717608003508	ABC-ATPase subunit interface; other site
717608003509	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717608003510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608003511	Walker A/P-loop; other site
717608003512	ATP binding site [chemical binding]; other site
717608003513	Q-loop/lid; other site
717608003514	ABC transporter signature motif; other site
717608003515	Walker B; other site
717608003516	D-loop; other site
717608003517	H-loop/switch region; other site
717608003518	TOBE domain; Region: TOBE_2; pfam08402
717608003519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608003520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608003521	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717608003522	dimerization interface [polypeptide binding]; other site
717608003523	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
717608003524	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
717608003525	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
717608003526	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
717608003527	rRNA interaction site [nucleotide binding]; other site
717608003528	S8 interaction site; other site
717608003529	putative laminin-1 binding site; other site
717608003530	elongation factor Ts; Provisional; Region: tsf; PRK09377
717608003531	UBA/TS-N domain; Region: UBA; pfam00627
717608003532	Elongation factor TS; Region: EF_TS; pfam00889
717608003533	Elongation factor TS; Region: EF_TS; pfam00889
717608003534	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717608003535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608003536	dimer interface [polypeptide binding]; other site
717608003537	conserved gate region; other site
717608003538	putative PBP binding loops; other site
717608003539	ABC-ATPase subunit interface; other site
717608003540	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
717608003541	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
717608003542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608003543	dimer interface [polypeptide binding]; other site
717608003544	conserved gate region; other site
717608003545	putative PBP binding loops; other site
717608003546	ABC-ATPase subunit interface; other site
717608003547	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
717608003548	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608003549	Walker A/P-loop; other site
717608003550	ATP binding site [chemical binding]; other site
717608003551	Q-loop/lid; other site
717608003552	ABC transporter signature motif; other site
717608003553	Walker B; other site
717608003554	D-loop; other site
717608003555	H-loop/switch region; other site
717608003556	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717608003557	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
717608003558	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608003559	Walker A/P-loop; other site
717608003560	ATP binding site [chemical binding]; other site
717608003561	Q-loop/lid; other site
717608003562	ABC transporter signature motif; other site
717608003563	Walker B; other site
717608003564	D-loop; other site
717608003565	H-loop/switch region; other site
717608003566	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
717608003567	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
717608003568	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
717608003569	peptide binding site [polypeptide binding]; other site
717608003570	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
717608003571	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
717608003572	peptide binding site [polypeptide binding]; other site
717608003573	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
717608003574	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
717608003575	active site
717608003576	C-terminal domain interface [polypeptide binding]; other site
717608003577	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
717608003578	active site
717608003579	N-terminal domain interface [polypeptide binding]; other site
717608003580	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
717608003581	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
717608003582	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608003583	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
717608003584	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608003585	Soluble P-type ATPase [General function prediction only]; Region: COG4087
717608003586	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
717608003587	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
717608003588	Transglycosylase; Region: Transgly; pfam00912
717608003589	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
717608003590	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
717608003591	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608003592	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
717608003593	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
717608003594	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
717608003595	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
717608003596	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717608003597	Na2 binding site [ion binding]; other site
717608003598	putative substrate binding site 1 [chemical binding]; other site
717608003599	Na binding site 1 [ion binding]; other site
717608003600	putative substrate binding site 2 [chemical binding]; other site
717608003601	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
717608003602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608003603	S-adenosylmethionine binding site [chemical binding]; other site
717608003604	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
717608003605	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
717608003606	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
717608003607	active site
717608003608	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
717608003609	DctM-like transporters; Region: DctM; pfam06808
717608003610	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
717608003611	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
717608003612	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
717608003613	active site
717608003614	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
717608003615	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
717608003616	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
717608003617	homotrimer interaction site [polypeptide binding]; other site
717608003618	zinc binding site [ion binding]; other site
717608003619	CDP-binding sites; other site
717608003620	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
717608003621	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
717608003622	active site
717608003623	HIGH motif; other site
717608003624	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
717608003625	KMSKS motif; other site
717608003626	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
717608003627	tRNA binding surface [nucleotide binding]; other site
717608003628	anticodon binding site; other site
717608003629	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
717608003630	dimerization interface [polypeptide binding]; other site
717608003631	active site
717608003632	metal binding site [ion binding]; metal-binding site
717608003633	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
717608003634	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
717608003635	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717608003636	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
717608003637	putative substrate binding pocket [chemical binding]; other site
717608003638	AC domain interface; other site
717608003639	catalytic triad [active]
717608003640	AB domain interface; other site
717608003641	interchain disulfide; other site
717608003642	isoaspartyl dipeptidase; Provisional; Region: PRK10657
717608003643	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608003644	active site
717608003645	hypothetical protein; Provisional; Region: PRK11588
717608003646	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
717608003647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608003648	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608003649	RNA binding surface [nucleotide binding]; other site
717608003650	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717608003651	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608003652	metal binding site [ion binding]; metal-binding site
717608003653	active site
717608003654	I-site; other site
717608003655	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
717608003656	metal binding site [ion binding]; metal-binding site
717608003657	Predicted membrane protein [Function unknown]; Region: COG1971
717608003658	Domain of unknown function DUF; Region: DUF204; pfam02659
717608003659	Domain of unknown function DUF; Region: DUF204; pfam02659
717608003660	YacP-like NYN domain; Region: NYN_YacP; pfam05991
717608003661	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
717608003662	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717608003663	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608003664	catalytic residue [active]
717608003665	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
717608003666	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
717608003667	argininosuccinate lyase; Provisional; Region: PRK00855
717608003668	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
717608003669	active sites [active]
717608003670	tetramer interface [polypeptide binding]; other site
717608003671	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608003672	active site
717608003673	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
717608003674	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
717608003675	NAD binding site [chemical binding]; other site
717608003676	ligand binding site [chemical binding]; other site
717608003677	catalytic site [active]
717608003678	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
717608003679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608003680	Zn2+ binding site [ion binding]; other site
717608003681	Mg2+ binding site [ion binding]; other site
717608003682	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717608003683	synthetase active site [active]
717608003684	NTP binding site [chemical binding]; other site
717608003685	metal binding site [ion binding]; metal-binding site
717608003686	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
717608003687	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
717608003688	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
717608003689	coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994
717608003690	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608003691	FeS/SAM binding site; other site
717608003692	histidyl-tRNA synthetase; Region: hisS; TIGR00442
717608003693	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
717608003694	dimer interface [polypeptide binding]; other site
717608003695	motif 1; other site
717608003696	active site
717608003697	motif 2; other site
717608003698	motif 3; other site
717608003699	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
717608003700	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
717608003701	dimer interface [polypeptide binding]; other site
717608003702	anticodon binding site; other site
717608003703	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
717608003704	homodimer interface [polypeptide binding]; other site
717608003705	motif 1; other site
717608003706	active site
717608003707	motif 2; other site
717608003708	GAD domain; Region: GAD; pfam02938
717608003709	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
717608003710	motif 3; other site
717608003711	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
717608003712	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
717608003713	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
717608003714	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
717608003715	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
717608003716	active site
717608003717	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717608003718	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717608003719	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717608003720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608003721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608003722	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608003723	dimerization interface [polypeptide binding]; other site
717608003724	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
717608003725	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608003726	metal binding site [ion binding]; metal-binding site
717608003727	Predicted membrane protein [Function unknown]; Region: COG1288
717608003728	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
717608003729	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717608003730	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608003731	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717608003732	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
717608003733	DNA binding residues [nucleotide binding]
717608003734	EamA-like transporter family; Region: EamA; pfam00892
717608003735	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
717608003736	EamA-like transporter family; Region: EamA; pfam00892
717608003737	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
717608003738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608003739	DNA-binding site [nucleotide binding]; DNA binding site
717608003740	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608003741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608003742	homodimer interface [polypeptide binding]; other site
717608003743	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
717608003744	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
717608003745	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
717608003746	putative ATP binding site [chemical binding]; other site
717608003747	putative substrate interface [chemical binding]; other site
717608003748	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608003749	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608003750	NAD synthetase; Reviewed; Region: nadE; PRK02628
717608003751	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
717608003752	multimer interface [polypeptide binding]; other site
717608003753	active site
717608003754	catalytic triad [active]
717608003755	protein interface 1 [polypeptide binding]; other site
717608003756	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
717608003757	homodimer interface [polypeptide binding]; other site
717608003758	NAD binding pocket [chemical binding]; other site
717608003759	ATP binding pocket [chemical binding]; other site
717608003760	Mg binding site [ion binding]; other site
717608003761	active-site loop [active]
717608003762	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
717608003763	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
717608003764	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717608003765	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
717608003766	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
717608003767	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
717608003768	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
717608003769	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608003770	DNA-binding site [nucleotide binding]; DNA binding site
717608003771	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
717608003772	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
717608003773	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
717608003774	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
717608003775	minor groove reading motif; other site
717608003776	helix-hairpin-helix signature motif; other site
717608003777	substrate binding pocket [chemical binding]; other site
717608003778	active site
717608003779	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
717608003780	DNA binding and oxoG recognition site [nucleotide binding]
717608003781	putative lipid kinase; Reviewed; Region: PRK13337
717608003782	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
717608003783	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717608003784	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
717608003785	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717608003786	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608003787	motif II; other site
717608003788	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717608003789	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
717608003790	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
717608003791	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717608003792	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
717608003793	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
717608003794	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
717608003795	ABC-ATPase subunit  interface; other site
717608003796	dimer interface [polypeptide binding]; other site
717608003797	putative PBP binding regions; other site
717608003798	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
717608003799	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
717608003800	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
717608003801	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
717608003802	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
717608003803	core domain interface [polypeptide binding]; other site
717608003804	delta subunit interface [polypeptide binding]; other site
717608003805	epsilon subunit interface [polypeptide binding]; other site
717608003806	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
717608003807	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
717608003808	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
717608003809	alpha subunit interaction interface [polypeptide binding]; other site
717608003810	Walker A motif; other site
717608003811	ATP binding site [chemical binding]; other site
717608003812	Walker B motif; other site
717608003813	inhibitor binding site; inhibition site
717608003814	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
717608003815	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
717608003816	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
717608003817	gamma subunit interface [polypeptide binding]; other site
717608003818	epsilon subunit interface [polypeptide binding]; other site
717608003819	LBP interface [polypeptide binding]; other site
717608003820	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717608003821	regulatory protein interface [polypeptide binding]; other site
717608003822	regulatory phosphorylation site [posttranslational modification]; other site
717608003823	Protein of unknown function (DUF554); Region: DUF554; pfam04474
717608003824	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
717608003825	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
717608003826	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
717608003827	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608003828	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
717608003829	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
717608003830	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
717608003831	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608003832	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
717608003833	active site
717608003834	catalytic tetrad [active]
717608003835	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
717608003836	active site 1 [active]
717608003837	dimer interface [polypeptide binding]; other site
717608003838	hexamer interface [polypeptide binding]; other site
717608003839	active site 2 [active]
717608003840	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608003841	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
717608003842	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
717608003843	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
717608003844	DNA binding residues [nucleotide binding]
717608003845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608003846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608003847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608003848	dimerization interface [polypeptide binding]; other site
717608003849	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
717608003850	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
717608003851	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608003852	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
717608003853	hypothetical protein; Provisional; Region: PRK05463
717608003854	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
717608003855	Chloramphenicol acetyltransferase; Region: CAT; cl02008
717608003856	Trp repressor protein; Region: Trp_repressor; cl17266
717608003857	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608003858	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608003859	non-specific DNA binding site [nucleotide binding]; other site
717608003860	salt bridge; other site
717608003861	sequence-specific DNA binding site [nucleotide binding]; other site
717608003862	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
717608003863	putative active site [active]
717608003864	catalytic site [active]
717608003865	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
717608003866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608003867	ATP binding site [chemical binding]; other site
717608003868	putative Mg++ binding site [ion binding]; other site
717608003869	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608003870	nucleotide binding region [chemical binding]; other site
717608003871	ATP-binding site [chemical binding]; other site
717608003872	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
717608003873	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
717608003874	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608003875	DNA methylase; Region: N6_N4_Mtase; cl17433
717608003876	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
717608003877	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
717608003878	Restriction endonuclease [Defense mechanisms]; Region: COG3587
717608003879	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608003880	ATP binding site [chemical binding]; other site
717608003881	putative Mg++ binding site [ion binding]; other site
717608003882	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
717608003883	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
717608003884	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
717608003885	Part of AAA domain; Region: AAA_19; pfam13245
717608003886	Family description; Region: UvrD_C_2; pfam13538
717608003887	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
717608003888	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717608003889	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717608003890	Walker A/P-loop; other site
717608003891	ATP binding site [chemical binding]; other site
717608003892	Q-loop/lid; other site
717608003893	ABC transporter signature motif; other site
717608003894	Walker B; other site
717608003895	D-loop; other site
717608003896	H-loop/switch region; other site
717608003897	Cobalt transport protein; Region: CbiQ; cl00463
717608003898	cobalt transport protein CbiN; Provisional; Region: PRK02898
717608003899	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
717608003900	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
717608003901	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608003902	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608003903	dimerization interface [polypeptide binding]; other site
717608003904	LysR substrate binding domain; Region: LysR_substrate; pfam03466
717608003905	glutaminase A; Region: Gln_ase; TIGR03814
717608003906	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
717608003907	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608003908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608003909	active site
717608003910	phosphorylation site [posttranslational modification]
717608003911	intermolecular recognition site; other site
717608003912	dimerization interface [polypeptide binding]; other site
717608003913	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608003914	DNA binding site [nucleotide binding]
717608003915	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
717608003916	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
717608003917	folate binding site [chemical binding]; other site
717608003918	NADP+ binding site [chemical binding]; other site
717608003919	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
717608003920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
717608003921	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717608003922	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
717608003923	classical (c) SDRs; Region: SDR_c; cd05233
717608003924	NAD(P) binding site [chemical binding]; other site
717608003925	active site
717608003926	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
717608003927	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
717608003928	active site
717608003929	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
717608003930	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
717608003931	FAD binding pocket [chemical binding]; other site
717608003932	FAD binding motif [chemical binding]; other site
717608003933	phosphate binding motif [ion binding]; other site
717608003934	beta-alpha-beta structure motif; other site
717608003935	NAD binding pocket [chemical binding]; other site
717608003936	Iron coordination center [ion binding]; other site
717608003937	putative oxidoreductase; Provisional; Region: PRK12831
717608003938	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608003939	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
717608003940	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608003941	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
717608003942	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
717608003943	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
717608003944	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
717608003945	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
717608003946	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
717608003947	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
717608003948	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
717608003949	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
717608003950	FeoA domain; Region: FeoA; pfam04023
717608003951	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
717608003952	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
717608003953	G1 box; other site
717608003954	GTP/Mg2+ binding site [chemical binding]; other site
717608003955	Switch I region; other site
717608003956	G2 box; other site
717608003957	G3 box; other site
717608003958	Switch II region; other site
717608003959	G4 box; other site
717608003960	G5 box; other site
717608003961	Nucleoside recognition; Region: Gate; pfam07670
717608003962	Nucleoside recognition; Region: Gate; pfam07670
717608003963	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717608003964	metal-binding site [ion binding]
717608003965	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
717608003966	putative DNA binding helix; other site
717608003967	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
717608003968	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608003969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608003970	motif II; other site
717608003971	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
717608003972	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
717608003973	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
717608003974	substrate binding site [chemical binding]; other site
717608003975	multimerization interface [polypeptide binding]; other site
717608003976	ATP binding site [chemical binding]; other site
717608003977	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
717608003978	thiamine phosphate binding site [chemical binding]; other site
717608003979	active site
717608003980	pyrophosphate binding site [ion binding]; other site
717608003981	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717608003982	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608003983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608003984	motif II; other site
717608003985	Domain of unknown function DUF77; Region: DUF77; pfam01910
717608003986	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608003987	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717608003988	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608003989	active site
717608003990	catalytic tetrad [active]
717608003991	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608003992	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717608003993	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608003994	active site
717608003995	catalytic tetrad [active]
717608003996	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608003997	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
717608003998	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
717608003999	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608004000	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608004001	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
717608004002	catalytic residues [active]
717608004003	Recombinase; Region: Recombinase; pfam07508
717608004004	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608004005	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608004006	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
717608004007	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
717608004008	MobA/MobL family; Region: MobA_MobL; pfam03389
717608004009	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608004010	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608004011	putative catalytic residues [active]
717608004012	catalytic nucleophile [active]
717608004013	Recombinase; Region: Recombinase; pfam07508
717608004014	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608004015	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608004016	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608004017	Domain of unknown function (DUF329); Region: DUF329; cl01144
717608004018	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
717608004019	Divergent AAA domain; Region: AAA_4; pfam04326
717608004020	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
717608004021	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717608004022	putative DNA binding site [nucleotide binding]; other site
717608004023	putative Zn2+ binding site [ion binding]; other site
717608004024	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608004025	hypothetical protein; Validated; Region: PRK08116
717608004026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608004027	Walker A motif; other site
717608004028	ATP binding site [chemical binding]; other site
717608004029	Walker B motif; other site
717608004030	arginine finger; other site
717608004031	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608004032	T-DNA border endonuclease VirD1; Region: VirD1; cl17530
717608004033	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608004034	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608004035	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608004036	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
717608004037	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144
717608004038	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608004039	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
717608004040	FMN binding site [chemical binding]; other site
717608004041	dimer interface [polypeptide binding]; other site
717608004042	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
717608004043	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
717608004044	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717608004045	MarR family; Region: MarR_2; pfam12802
717608004046	Predicted membrane protein [Function unknown]; Region: COG2364
717608004047	asparagine synthetase B; Provisional; Region: asnB; PRK09431
717608004048	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
717608004049	dimer interface [polypeptide binding]; other site
717608004050	active site
717608004051	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
717608004052	Ligand Binding Site [chemical binding]; other site
717608004053	Molecular Tunnel; other site
717608004054	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
717608004055	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
717608004056	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
717608004057	CTP synthetase; Validated; Region: pyrG; PRK05380
717608004058	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
717608004059	Catalytic site [active]
717608004060	active site
717608004061	UTP binding site [chemical binding]; other site
717608004062	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
717608004063	active site
717608004064	putative oxyanion hole; other site
717608004065	catalytic triad [active]
717608004066	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
717608004067	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
717608004068	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
717608004069	catalytic site [active]
717608004070	subunit interface [polypeptide binding]; other site
717608004071	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
717608004072	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717608004073	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
717608004074	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
717608004075	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
717608004076	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717608004077	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
717608004078	substrate binding site [chemical binding]; other site
717608004079	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
717608004080	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608004081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608004082	homodimer interface [polypeptide binding]; other site
717608004083	catalytic residue [active]
717608004084	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608004085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004086	active site
717608004087	phosphorylation site [posttranslational modification]
717608004088	intermolecular recognition site; other site
717608004089	dimerization interface [polypeptide binding]; other site
717608004090	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608004091	DNA binding site [nucleotide binding]
717608004092	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
717608004093	Citrate transporter; Region: CitMHS; pfam03600
717608004094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608004095	dimer interface [polypeptide binding]; other site
717608004096	phosphorylation site [posttranslational modification]
717608004097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004098	ATP binding site [chemical binding]; other site
717608004099	Mg2+ binding site [ion binding]; other site
717608004100	G-X-G motif; other site
717608004101	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
717608004102	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608004103	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
717608004104	trimer interface [polypeptide binding]; other site
717608004105	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
717608004106	ApbE family; Region: ApbE; pfam02424
717608004107	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
717608004108	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
717608004109	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
717608004110	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
717608004111	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717608004112	synthetase active site [active]
717608004113	NTP binding site [chemical binding]; other site
717608004114	metal binding site [ion binding]; metal-binding site
717608004115	Cache domain; Region: Cache_1; pfam02743
717608004116	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717608004117	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608004118	metal binding site [ion binding]; metal-binding site
717608004119	active site
717608004120	I-site; other site
717608004121	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
717608004122	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
717608004123	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
717608004124	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
717608004125	FAD binding site [chemical binding]; other site
717608004126	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
717608004127	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
717608004128	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
717608004129	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
717608004130	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
717608004131	substrate binding pocket [chemical binding]; other site
717608004132	dimer interface [polypeptide binding]; other site
717608004133	inhibitor binding site; inhibition site
717608004134	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
717608004135	B12 binding site [chemical binding]; other site
717608004136	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717608004137	dimerization domain swap beta strand [polypeptide binding]; other site
717608004138	regulatory protein interface [polypeptide binding]; other site
717608004139	active site
717608004140	regulatory phosphorylation site [posttranslational modification]; other site
717608004141	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
717608004142	active site
717608004143	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
717608004144	hypothetical protein; Provisional; Region: PRK09609
717608004145	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
717608004146	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
717608004147	homodimer interface [polypeptide binding]; other site
717608004148	substrate-cofactor binding pocket; other site
717608004149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608004150	catalytic residue [active]
717608004151	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
717608004152	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
717608004153	synthetase active site [active]
717608004154	NTP binding site [chemical binding]; other site
717608004155	metal binding site [ion binding]; metal-binding site
717608004156	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
717608004157	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717608004158	putative active site [active]
717608004159	putative NTP binding site [chemical binding]; other site
717608004160	putative nucleic acid binding site [nucleotide binding]; other site
717608004161	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
717608004162	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
717608004163	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
717608004164	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
717608004165	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
717608004166	HsdM N-terminal domain; Region: HsdM_N; pfam12161
717608004167	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717608004168	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608004169	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
717608004170	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608004171	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
717608004172	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
717608004173	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608004174	ATP binding site [chemical binding]; other site
717608004175	putative Mg++ binding site [ion binding]; other site
717608004176	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
717608004177	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
717608004178	active site
717608004179	dimer interface [polypeptide binding]; other site
717608004180	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
717608004181	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
717608004182	FAD binding pocket [chemical binding]; other site
717608004183	FAD binding motif [chemical binding]; other site
717608004184	phosphate binding motif [ion binding]; other site
717608004185	beta-alpha-beta structure motif; other site
717608004186	NAD binding pocket [chemical binding]; other site
717608004187	Iron coordination center [ion binding]; other site
717608004188	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
717608004189	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
717608004190	heterodimer interface [polypeptide binding]; other site
717608004191	active site
717608004192	FMN binding site [chemical binding]; other site
717608004193	homodimer interface [polypeptide binding]; other site
717608004194	substrate binding site [chemical binding]; other site
717608004195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608004196	active site
717608004197	VanZ like family; Region: VanZ; pfam04892
717608004198	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
717608004199	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
717608004200	AIR carboxylase; Region: AIRC; pfam00731
717608004201	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
717608004202	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
717608004203	dimerization interface [polypeptide binding]; other site
717608004204	putative ATP binding site [chemical binding]; other site
717608004205	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
717608004206	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
717608004207	active site
717608004208	substrate binding site [chemical binding]; other site
717608004209	cosubstrate binding site; other site
717608004210	catalytic site [active]
717608004211	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
717608004212	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
717608004213	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
717608004214	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
717608004215	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
717608004216	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
717608004217	active site
717608004218	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717608004219	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
717608004220	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
717608004221	active site
717608004222	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
717608004223	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
717608004224	putative NADH binding site [chemical binding]; other site
717608004225	putative active site [active]
717608004226	nudix motif; other site
717608004227	putative metal binding site [ion binding]; other site
717608004228	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
717608004229	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
717608004230	putative valine binding site [chemical binding]; other site
717608004231	dimer interface [polypeptide binding]; other site
717608004232	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
717608004233	ketol-acid reductoisomerase; Provisional; Region: PRK05479
717608004234	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
717608004235	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
717608004236	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608004237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608004238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608004239	dimerization interface [polypeptide binding]; other site
717608004240	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
717608004241	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
717608004242	substrate binding site [chemical binding]; other site
717608004243	ligand binding site [chemical binding]; other site
717608004244	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
717608004245	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
717608004246	substrate binding site [chemical binding]; other site
717608004247	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608004248	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608004249	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
717608004250	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717608004251	Walker A/P-loop; other site
717608004252	ATP binding site [chemical binding]; other site
717608004253	Q-loop/lid; other site
717608004254	ABC transporter signature motif; other site
717608004255	Walker B; other site
717608004256	D-loop; other site
717608004257	H-loop/switch region; other site
717608004258	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717608004259	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608004260	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717608004261	TM-ABC transporter signature motif; other site
717608004262	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
717608004263	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608004264	putative ligand binding site [chemical binding]; other site
717608004265	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
717608004266	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717608004267	nucleotide binding site [chemical binding]; other site
717608004268	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
717608004269	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717608004270	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
717608004271	putative substrate binding site [chemical binding]; other site
717608004272	putative ATP binding site [chemical binding]; other site
717608004273	Response regulator receiver domain; Region: Response_reg; pfam00072
717608004274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004275	active site
717608004276	phosphorylation site [posttranslational modification]
717608004277	intermolecular recognition site; other site
717608004278	dimerization interface [polypeptide binding]; other site
717608004279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004280	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608004281	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004282	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
717608004283	Histidine kinase; Region: His_kinase; pfam06580
717608004284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004285	ATP binding site [chemical binding]; other site
717608004286	Mg2+ binding site [ion binding]; other site
717608004287	G-X-G motif; other site
717608004288	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
717608004289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608004290	Walker A/P-loop; other site
717608004291	ATP binding site [chemical binding]; other site
717608004292	Q-loop/lid; other site
717608004293	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608004294	ABC transporter signature motif; other site
717608004295	ABC transporter signature motif; other site
717608004296	Walker B; other site
717608004297	Walker B; other site
717608004298	D-loop; other site
717608004299	H-loop/switch region; other site
717608004300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608004301	Q-loop/lid; other site
717608004302	ABC transporter signature motif; other site
717608004303	Walker B; other site
717608004304	D-loop; other site
717608004305	H-loop/switch region; other site
717608004306	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
717608004307	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
717608004308	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
717608004309	Peptidase M16C associated; Region: M16C_assoc; pfam08367
717608004310	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
717608004311	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608004312	active site
717608004313	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
717608004314	Acid Phosphatase; Region: Acid_PPase; cl17256
717608004315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608004316	motif II; other site
717608004317	Chloramphenicol acetyltransferase; Region: CAT; cl02008
717608004318	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
717608004319	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
717608004320	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608004321	motif II; other site
717608004322	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608004323	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608004324	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
717608004325	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
717608004326	active site
717608004327	catalytic motif [active]
717608004328	Zn binding site [ion binding]; other site
717608004329	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
717608004330	Domain of unknown function DUF20; Region: UPF0118; pfam01594
717608004331	Stage II sporulation protein; Region: SpoIID; pfam08486
717608004332	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
717608004333	6-phosphofructokinase; Provisional; Region: PRK14072
717608004334	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
717608004335	active site
717608004336	ADP/pyrophosphate binding site [chemical binding]; other site
717608004337	allosteric effector site; other site
717608004338	dimerization interface [polypeptide binding]; other site
717608004339	fructose-1,6-bisphosphate binding site; other site
717608004340	PBP superfamily domain; Region: PBP_like_2; cl17296
717608004341	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
717608004342	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
717608004343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608004344	dimer interface [polypeptide binding]; other site
717608004345	conserved gate region; other site
717608004346	putative PBP binding loops; other site
717608004347	ABC-ATPase subunit interface; other site
717608004348	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
717608004349	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
717608004350	Walker A/P-loop; other site
717608004351	ATP binding site [chemical binding]; other site
717608004352	Q-loop/lid; other site
717608004353	ABC transporter signature motif; other site
717608004354	Walker B; other site
717608004355	D-loop; other site
717608004356	H-loop/switch region; other site
717608004357	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
717608004358	PhoU domain; Region: PhoU; pfam01895
717608004359	PhoU domain; Region: PhoU; pfam01895
717608004360	enoyl-CoA hydratase; Provisional; Region: PRK09245
717608004361	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717608004362	substrate binding site [chemical binding]; other site
717608004363	oxyanion hole (OAH) forming residues; other site
717608004364	trimer interface [polypeptide binding]; other site
717608004365	hypothetical protein; Provisional; Region: PRK05590
717608004366	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
717608004367	DNA-binding site [nucleotide binding]; DNA binding site
717608004368	RNA-binding motif; other site
717608004369	RNase_H superfamily; Region: RNase_H_2; pfam13482
717608004370	active site
717608004371	catalytic site [active]
717608004372	substrate binding site [chemical binding]; other site
717608004373	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
717608004374	RuvA N terminal domain; Region: RuvA_N; pfam01330
717608004375	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
717608004376	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
717608004377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608004378	Walker A motif; other site
717608004379	ATP binding site [chemical binding]; other site
717608004380	Walker B motif; other site
717608004381	arginine finger; other site
717608004382	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
717608004383	Cell division protein ZapA; Region: ZapA; pfam05164
717608004384	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
717608004385	Peptidase family U32; Region: Peptidase_U32; pfam01136
717608004386	Collagenase; Region: DUF3656; pfam12392
717608004387	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
717608004388	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
717608004389	hypothetical protein; Provisional; Region: PRK10621
717608004390	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
717608004391	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717608004392	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608004393	metal binding site [ion binding]; metal-binding site
717608004394	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
717608004395	active site
717608004396	Ap6A binding site [chemical binding]; other site
717608004397	nudix motif; other site
717608004398	metal binding site [ion binding]; metal-binding site
717608004399	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
717608004400	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
717608004401	active site
717608004402	Zn binding site [ion binding]; other site
717608004403	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
717608004404	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608004405	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608004406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608004407	Walker A/P-loop; other site
717608004408	ATP binding site [chemical binding]; other site
717608004409	Q-loop/lid; other site
717608004410	ABC transporter signature motif; other site
717608004411	Walker B; other site
717608004412	D-loop; other site
717608004413	H-loop/switch region; other site
717608004414	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608004415	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608004416	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717608004417	Walker A/P-loop; other site
717608004418	ATP binding site [chemical binding]; other site
717608004419	Q-loop/lid; other site
717608004420	ABC transporter signature motif; other site
717608004421	Walker B; other site
717608004422	D-loop; other site
717608004423	H-loop/switch region; other site
717608004424	Protein of unknown function (DUF523); Region: DUF523; pfam04463
717608004425	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608004426	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608004427	non-specific DNA binding site [nucleotide binding]; other site
717608004428	salt bridge; other site
717608004429	sequence-specific DNA binding site [nucleotide binding]; other site
717608004430	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717608004431	Na2 binding site [ion binding]; other site
717608004432	putative substrate binding site 1 [chemical binding]; other site
717608004433	Na binding site 1 [ion binding]; other site
717608004434	putative substrate binding site 2 [chemical binding]; other site
717608004435	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
717608004436	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
717608004437	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
717608004438	putative deacylase active site [active]
717608004439	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608004440	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717608004441	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
717608004442	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608004443	active site
717608004444	HIGH motif; other site
717608004445	nucleotide binding site [chemical binding]; other site
717608004446	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
717608004447	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
717608004448	active site
717608004449	KMSKS motif; other site
717608004450	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
717608004451	tRNA binding surface [nucleotide binding]; other site
717608004452	anticodon binding site; other site
717608004453	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
717608004454	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
717608004455	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717608004456	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608004457	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
717608004458	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608004459	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608004460	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
717608004461	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
717608004462	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
717608004463	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717608004464	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717608004465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608004466	Tetratricopeptide repeat; Region: TPR_16; pfam13432
717608004467	binding surface
717608004468	TPR motif; other site
717608004469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608004470	binding surface
717608004471	TPR repeat; Region: TPR_11; pfam13414
717608004472	TPR motif; other site
717608004473	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
717608004474	anti sigma factor interaction site; other site
717608004475	regulatory phosphorylation site [posttranslational modification]; other site
717608004476	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
717608004477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004478	ATP binding site [chemical binding]; other site
717608004479	Mg2+ binding site [ion binding]; other site
717608004480	G-X-G motif; other site
717608004481	sporulation sigma factor SigF; Validated; Region: PRK05572
717608004482	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608004483	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717608004484	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608004485	DNA binding residues [nucleotide binding]
717608004486	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
717608004487	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
717608004488	SpoVA protein; Region: SpoVA; pfam03862
717608004489	amino acid transporter; Region: 2A0306; TIGR00909
717608004490	Response regulator receiver domain; Region: Response_reg; pfam00072
717608004491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004492	active site
717608004493	phosphorylation site [posttranslational modification]
717608004494	intermolecular recognition site; other site
717608004495	dimerization interface [polypeptide binding]; other site
717608004496	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717608004497	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004499	stage V sporulation protein AD; Provisional; Region: PRK12404
717608004500	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
717608004501	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
717608004502	Transglycosylase; Region: Transgly; pfam00912
717608004503	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
717608004504	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
717608004505	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
717608004506	G1 box; other site
717608004507	putative GEF interaction site [polypeptide binding]; other site
717608004508	GTP/Mg2+ binding site [chemical binding]; other site
717608004509	Switch I region; other site
717608004510	G2 box; other site
717608004511	G3 box; other site
717608004512	Switch II region; other site
717608004513	G4 box; other site
717608004514	G5 box; other site
717608004515	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
717608004516	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
717608004517	single-stranded DNA-binding protein; Provisional; Region: PRK05813
717608004518	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
717608004519	dimer interface [polypeptide binding]; other site
717608004520	ssDNA binding site [nucleotide binding]; other site
717608004521	tetramer (dimer of dimers) interface [polypeptide binding]; other site
717608004522	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608004523	Walker A motif; other site
717608004524	ATP binding site [chemical binding]; other site
717608004525	Walker B motif; other site
717608004526	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
717608004527	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
717608004528	dimer interface [polypeptide binding]; other site
717608004529	active site
717608004530	catalytic residue [active]
717608004531	dihydrodipicolinate reductase; Provisional; Region: PRK00048
717608004532	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
717608004533	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
717608004534	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
717608004535	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
717608004536	tetramer interface [polypeptide binding]; other site
717608004537	active site
717608004538	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
717608004539	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
717608004540	GDP-binding site [chemical binding]; other site
717608004541	ACT binding site; other site
717608004542	IMP binding site; other site
717608004543	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717608004544	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608004545	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608004546	ABC transporter; Region: ABC_tran_2; pfam12848
717608004547	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608004548	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
717608004549	Uncharacterized conserved protein [Function unknown]; Region: COG0062
717608004550	putative carbohydrate kinase; Provisional; Region: PRK10565
717608004551	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
717608004552	putative substrate binding site [chemical binding]; other site
717608004553	putative ATP binding site [chemical binding]; other site
717608004554	Domain of unknown function DUF21; Region: DUF21; pfam01595
717608004555	FOG: CBS domain [General function prediction only]; Region: COG0517
717608004556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
717608004557	Transporter associated domain; Region: CorC_HlyC; pfam03471
717608004558	hypothetical protein; Validated; Region: PRK00110
717608004559	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
717608004560	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
717608004561	Cl- selectivity filter; other site
717608004562	Cl- binding residues [ion binding]; other site
717608004563	pore gating glutamate residue; other site
717608004564	dimer interface [polypeptide binding]; other site
717608004565	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
717608004566	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
717608004567	active site
717608004568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004569	active site
717608004570	phosphorylation site [posttranslational modification]
717608004571	intermolecular recognition site; other site
717608004572	dimerization interface [polypeptide binding]; other site
717608004573	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717608004574	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004575	Cache domain; Region: Cache_1; pfam02743
717608004576	HAMP domain; Region: HAMP; pfam00672
717608004577	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
717608004578	Histidine kinase; Region: His_kinase; pfam06580
717608004579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004580	ATP binding site [chemical binding]; other site
717608004581	Mg2+ binding site [ion binding]; other site
717608004582	G-X-G motif; other site
717608004583	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
717608004584	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608004585	putative ligand binding site [chemical binding]; other site
717608004586	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
717608004587	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608004588	active site
717608004589	HIGH motif; other site
717608004590	nucleotide binding site [chemical binding]; other site
717608004591	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
717608004592	active site
717608004593	KMSKS motif; other site
717608004594	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
717608004595	tRNA binding surface [nucleotide binding]; other site
717608004596	anticodon binding site; other site
717608004597	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
717608004598	homodimer interface [polypeptide binding]; other site
717608004599	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
717608004600	active site pocket [active]
717608004601	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
717608004602	Stage II sporulation protein; Region: SpoIID; pfam08486
717608004603	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
717608004604	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
717608004605	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
717608004606	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
717608004607	TrkA-N domain; Region: TrkA_N; pfam02254
717608004608	TrkA-C domain; Region: TrkA_C; pfam02080
717608004609	TrkA-N domain; Region: TrkA_N; pfam02254
717608004610	TrkA-C domain; Region: TrkA_C; pfam02080
717608004611	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
717608004612	CotJB protein; Region: CotJB; pfam12652
717608004613	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
717608004614	Abi-like protein; Region: Abi_2; pfam07751
717608004615	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
717608004616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608004617	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
717608004618	Walker A motif; other site
717608004619	ATP binding site [chemical binding]; other site
717608004620	Walker B motif; other site
717608004621	arginine finger; other site
717608004622	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608004623	Protein of unknown function (DUF551); Region: DUF551; pfam04448
717608004624	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
717608004625	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
717608004626	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
717608004627	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
717608004628	Phage tail tube protein FII; Region: Phage_tube; cl01390
717608004629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608004630	non-specific DNA binding site [nucleotide binding]; other site
717608004631	salt bridge; other site
717608004632	sequence-specific DNA binding site [nucleotide binding]; other site
717608004633	Phage Tail Protein X; Region: Phage_tail_X; cl02088
717608004634	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
717608004635	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717608004636	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
717608004637	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
717608004638	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
717608004639	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
717608004640	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
717608004641	amidase catalytic site [active]
717608004642	Zn binding residues [ion binding]; other site
717608004643	substrate binding site [chemical binding]; other site
717608004644	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
717608004645	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608004646	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
717608004647	catalytic residues [active]
717608004648	catalytic nucleophile [active]
717608004649	Recombinase; Region: Recombinase; pfam07508
717608004650	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608004651	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608004652	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608004653	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608004654	FtsX-like permease family; Region: FtsX; pfam02687
717608004655	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608004656	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608004657	Walker A/P-loop; other site
717608004658	ATP binding site [chemical binding]; other site
717608004659	Q-loop/lid; other site
717608004660	ABC transporter signature motif; other site
717608004661	Walker B; other site
717608004662	D-loop; other site
717608004663	H-loop/switch region; other site
717608004664	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608004665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608004666	dimer interface [polypeptide binding]; other site
717608004667	phosphorylation site [posttranslational modification]
717608004668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004669	ATP binding site [chemical binding]; other site
717608004670	Mg2+ binding site [ion binding]; other site
717608004671	G-X-G motif; other site
717608004672	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608004673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004674	active site
717608004675	phosphorylation site [posttranslational modification]
717608004676	intermolecular recognition site; other site
717608004677	dimerization interface [polypeptide binding]; other site
717608004678	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608004679	DNA binding site [nucleotide binding]
717608004680	Helix-turn-helix domain; Region: HTH_17; pfam12728
717608004681	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608004682	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608004683	non-specific DNA binding site [nucleotide binding]; other site
717608004684	salt bridge; other site
717608004685	sequence-specific DNA binding site [nucleotide binding]; other site
717608004686	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
717608004687	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608004688	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
717608004689	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
717608004690	Antirestriction protein (ArdA); Region: ArdA; pfam07275
717608004691	Domain of unknown function (DUF955); Region: DUF955; cl01076
717608004692	YodL-like; Region: YodL; pfam14191
717608004693	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
717608004694	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717608004695	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
717608004696	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717608004697	TIGR02594 family protein; Region: TIGR02594
717608004698	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717608004699	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608004700	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608004701	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608004702	putative catalytic residues [active]
717608004703	catalytic nucleophile [active]
717608004704	Recombinase; Region: Recombinase; pfam07508
717608004705	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608004706	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608004707	Virulence-associated protein E; Region: VirE; pfam05272
717608004708	MobA/MobL family; Region: MobA_MobL; pfam03389
717608004709	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
717608004710	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
717608004711	putative Zn2+ binding site [ion binding]; other site
717608004712	putative DNA binding site [nucleotide binding]; other site
717608004713	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608004714	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608004715	non-specific DNA binding site [nucleotide binding]; other site
717608004716	salt bridge; other site
717608004717	sequence-specific DNA binding site [nucleotide binding]; other site
717608004718	Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915
717608004719	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608004720	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717608004721	salt bridge; other site
717608004722	non-specific DNA binding site [nucleotide binding]; other site
717608004723	sequence-specific DNA binding site [nucleotide binding]; other site
717608004724	Maff2 family; Region: Maff2; pfam12750
717608004725	Helix-turn-helix domain; Region: HTH_36; pfam13730
717608004726	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
717608004727	putative ADP-ribose binding site [chemical binding]; other site
717608004728	putative active site [active]
717608004729	D-serine dehydratase; Provisional; Region: PRK02991
717608004730	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
717608004731	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608004732	catalytic residue [active]
717608004733	Chromate transporter; Region: Chromate_transp; pfam02417
717608004734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608004735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608004736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
717608004737	dimerization interface [polypeptide binding]; other site
717608004738	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
717608004739	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717608004740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608004741	active site
717608004742	motif I; other site
717608004743	motif II; other site
717608004744	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608004745	asparagine synthetase AsnA; Provisional; Region: PRK05425
717608004746	motif 1; other site
717608004747	dimer interface [polypeptide binding]; other site
717608004748	active site
717608004749	motif 2; other site
717608004750	motif 3; other site
717608004751	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
717608004752	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
717608004753	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
717608004754	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
717608004755	active site
717608004756	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
717608004757	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
717608004758	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608004759	putative efflux protein, MATE family; Region: matE; TIGR00797
717608004760	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
717608004761	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
717608004762	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
717608004763	dimanganese center [ion binding]; other site
717608004764	CotJB protein; Region: CotJB; pfam12652
717608004765	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
717608004766	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
717608004767	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
717608004768	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
717608004769	carboxyltransferase (CT) interaction site; other site
717608004770	biotinylation site [posttranslational modification]; other site
717608004771	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
717608004772	oxaloacetate decarboxylase; Provisional; Region: PRK12331
717608004773	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
717608004774	active site
717608004775	catalytic residues [active]
717608004776	metal binding site [ion binding]; metal-binding site
717608004777	homodimer binding site [polypeptide binding]; other site
717608004778	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608004779	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
717608004780	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
717608004781	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
717608004782	dockerin binding interface; other site
717608004783	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
717608004784	GPCR-chaperone; Region: GPCR_chapero_1; pfam11904
717608004785	Predicted transcriptional regulators [Transcription]; Region: COG1725
717608004786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608004787	DNA-binding site [nucleotide binding]; DNA binding site
717608004788	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
717608004789	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
717608004790	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
717608004791	ADP binding site [chemical binding]; other site
717608004792	phosphagen binding site; other site
717608004793	substrate specificity loop; other site
717608004794	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
717608004795	Clp amino terminal domain; Region: Clp_N; pfam02861
717608004796	Clp amino terminal domain; Region: Clp_N; pfam02861
717608004797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608004798	Walker A motif; other site
717608004799	ATP binding site [chemical binding]; other site
717608004800	Walker B motif; other site
717608004801	arginine finger; other site
717608004802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608004803	Walker A motif; other site
717608004804	ATP binding site [chemical binding]; other site
717608004805	Walker B motif; other site
717608004806	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
717608004807	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
717608004808	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
717608004809	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
717608004810	active site
717608004811	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
717608004812	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
717608004813	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
717608004814	regulatory protein interface [polypeptide binding]; other site
717608004815	regulatory phosphorylation site [posttranslational modification]; other site
717608004816	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
717608004817	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
717608004818	DEAD_2; Region: DEAD_2; pfam06733
717608004819	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
717608004820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608004821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608004822	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608004823	dimerization interface [polypeptide binding]; other site
717608004824	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253
717608004825	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
717608004826	putative active site [active]
717608004827	Zn binding site [ion binding]; other site
717608004828	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
717608004829	active site
717608004830	Zn binding site [ion binding]; other site
717608004831	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
717608004832	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
717608004833	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717608004834	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
717608004835	catalytic core [active]
717608004836	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
717608004837	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
717608004838	active site
717608004839	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
717608004840	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
717608004841	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
717608004842	dimerization interface [polypeptide binding]; other site
717608004843	ATP binding site [chemical binding]; other site
717608004844	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
717608004845	dimerization interface [polypeptide binding]; other site
717608004846	ATP binding site [chemical binding]; other site
717608004847	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
717608004848	putative active site [active]
717608004849	catalytic triad [active]
717608004850	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608004851	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
717608004852	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
717608004853	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717608004854	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608004855	active site
717608004856	catalytic tetrad [active]
717608004857	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608004858	flavoprotein, HI0933 family; Region: TIGR00275
717608004859	Predicted permeases [General function prediction only]; Region: COG0701
717608004860	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
717608004861	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
717608004862	Low molecular weight phosphatase family; Region: LMWPc; cd00115
717608004863	active site
717608004864	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
717608004865	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
717608004866	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608004867	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
717608004868	catalytic residues [active]
717608004869	catalytic nucleophile [active]
717608004870	Presynaptic Site I dimer interface [polypeptide binding]; other site
717608004871	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
717608004872	Synaptic Flat tetramer interface [polypeptide binding]; other site
717608004873	Synaptic Site I dimer interface [polypeptide binding]; other site
717608004874	DNA binding site [nucleotide binding]
717608004875	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
717608004876	T5orf172 domain; Region: T5orf172; cl17462
717608004877	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608004878	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608004879	non-specific DNA binding site [nucleotide binding]; other site
717608004880	salt bridge; other site
717608004881	sequence-specific DNA binding site [nucleotide binding]; other site
717608004882	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608004883	Walker A motif; other site
717608004884	ATP binding site [chemical binding]; other site
717608004885	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
717608004886	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
717608004887	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608004888	HAMP domain; Region: HAMP; pfam00672
717608004889	dimerization interface [polypeptide binding]; other site
717608004890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608004891	dimer interface [polypeptide binding]; other site
717608004892	phosphorylation site [posttranslational modification]
717608004893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004894	ATP binding site [chemical binding]; other site
717608004895	Mg2+ binding site [ion binding]; other site
717608004896	G-X-G motif; other site
717608004897	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
717608004898	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
717608004899	active site
717608004900	Zn binding site [ion binding]; other site
717608004901	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
717608004902	Short C-terminal domain; Region: SHOCT; pfam09851
717608004903	cytidylate kinase; Provisional; Region: cmk; PRK00023
717608004904	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
717608004905	CMP-binding site; other site
717608004906	The sites determining sugar specificity; other site
717608004907	LytB protein; Region: LYTB; cl00507
717608004908	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
717608004909	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
717608004910	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
717608004911	RNA binding site [nucleotide binding]; other site
717608004912	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
717608004913	RNA binding site [nucleotide binding]; other site
717608004914	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
717608004915	RNA binding site [nucleotide binding]; other site
717608004916	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
717608004917	RNA binding site [nucleotide binding]; other site
717608004918	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
717608004919	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
717608004920	putative hexamer interface [polypeptide binding]; other site
717608004921	putative hexagonal pore; other site
717608004922	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
717608004923	putative hexamer interface [polypeptide binding]; other site
717608004924	putative hexagonal pore; other site
717608004925	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
717608004926	SLBB domain; Region: SLBB; pfam10531
717608004927	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
717608004928	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
717608004929	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
717608004930	putative hexamer interface [polypeptide binding]; other site
717608004931	putative hexagonal pore; other site
717608004932	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
717608004933	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
717608004934	dimer interface [polypeptide binding]; other site
717608004935	active site
717608004936	glycine loop; other site
717608004937	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
717608004938	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608004939	FeS/SAM binding site; other site
717608004940	propanediol utilization protein PduB; Provisional; Region: PRK15415
717608004941	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
717608004942	putative hexamer interface [polypeptide binding]; other site
717608004943	putative hexagonal pore; other site
717608004944	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
717608004945	putative hexamer interface [polypeptide binding]; other site
717608004946	putative hexagonal pore; other site
717608004947	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
717608004948	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
717608004949	Hexamer interface [polypeptide binding]; other site
717608004950	Hexagonal pore residue; other site
717608004951	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
717608004952	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
717608004953	Hexamer interface [polypeptide binding]; other site
717608004954	Hexagonal pore residue; other site
717608004955	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
717608004956	Hexamer/Pentamer interface [polypeptide binding]; other site
717608004957	central pore; other site
717608004958	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
717608004959	NAD(P) binding site [chemical binding]; other site
717608004960	catalytic residues [active]
717608004961	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
717608004962	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
717608004963	Hexamer interface [polypeptide binding]; other site
717608004964	Hexagonal pore residue; other site
717608004965	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
717608004966	Propanediol utilisation protein PduL; Region: PduL; pfam06130
717608004967	Propanediol utilisation protein PduL; Region: PduL; pfam06130
717608004968	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
717608004969	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717608004970	nucleotide binding site [chemical binding]; other site
717608004971	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
717608004972	putative catalytic cysteine [active]
717608004973	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
717608004974	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
717608004975	active site
717608004976	NAD binding site [chemical binding]; other site
717608004977	metal binding site [ion binding]; metal-binding site
717608004978	Sensory domain found in PocR; Region: PocR; pfam10114
717608004979	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
717608004980	Histidine kinase; Region: His_kinase; pfam06580
717608004981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608004982	Mg2+ binding site [ion binding]; other site
717608004983	G-X-G motif; other site
717608004984	Response regulator receiver domain; Region: Response_reg; pfam00072
717608004985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608004986	active site
717608004987	phosphorylation site [posttranslational modification]
717608004988	intermolecular recognition site; other site
717608004989	dimerization interface [polypeptide binding]; other site
717608004990	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
717608004992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608004993	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
717608004994	amphipathic channel; other site
717608004995	Asn-Pro-Ala signature motifs; other site
717608004996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717608004997	putative substrate translocation pore; other site
717608004998	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
717608004999	Predicted transcriptional regulators [Transcription]; Region: COG1695
717608005000	Predicted membrane protein [Function unknown]; Region: COG4709
717608005001	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
717608005002	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
717608005003	active site
717608005004	SAM binding site [chemical binding]; other site
717608005005	homodimer interface [polypeptide binding]; other site
717608005006	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
717608005007	active site
717608005008	SAM binding site [chemical binding]; other site
717608005009	homodimer interface [polypeptide binding]; other site
717608005010	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
717608005011	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
717608005012	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
717608005013	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
717608005014	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
717608005015	active site
717608005016	SAM binding site [chemical binding]; other site
717608005017	homodimer interface [polypeptide binding]; other site
717608005018	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
717608005019	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
717608005020	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
717608005021	active site
717608005022	putative homodimer interface [polypeptide binding]; other site
717608005023	SAM binding site [chemical binding]; other site
717608005024	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
717608005025	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
717608005026	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
717608005027	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608005028	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
717608005029	catalytic triad [active]
717608005030	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
717608005031	cobalamin synthase; Reviewed; Region: cobS; PRK00235
717608005032	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
717608005033	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
717608005034	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
717608005035	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608005036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608005037	homodimer interface [polypeptide binding]; other site
717608005038	catalytic residue [active]
717608005039	cobyric acid synthase; Provisional; Region: PRK00784
717608005040	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608005041	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608005042	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
717608005043	catalytic triad [active]
717608005044	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
717608005045	Precorrin-8X methylmutase; Region: CbiC; pfam02570
717608005046	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
717608005047	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
717608005048	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
717608005049	Domain of unknown function DUF20; Region: UPF0118; pfam01594
717608005050	Nitronate monooxygenase; Region: NMO; pfam03060
717608005051	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
717608005052	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
717608005053	domain interfaces; other site
717608005054	active site
717608005055	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
717608005056	active site
717608005057	SAM binding site [chemical binding]; other site
717608005058	homodimer interface [polypeptide binding]; other site
717608005059	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
717608005060	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
717608005061	active site
717608005062	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
717608005063	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
717608005064	active site
717608005065	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
717608005066	VanW like protein; Region: VanW; pfam04294
717608005067	G5 domain; Region: G5; pfam07501
717608005068	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
717608005069	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
717608005070	dimer interface [polypeptide binding]; other site
717608005071	PYR/PP interface [polypeptide binding]; other site
717608005072	TPP binding site [chemical binding]; other site
717608005073	substrate binding site [chemical binding]; other site
717608005074	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
717608005075	Domain of unknown function; Region: EKR; pfam10371
717608005076	4Fe-4S binding domain; Region: Fer4_6; pfam12837
717608005077	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
717608005078	TPP-binding site [chemical binding]; other site
717608005079	dimer interface [polypeptide binding]; other site
717608005080	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
717608005081	DNA protecting protein DprA; Region: dprA; TIGR00732
717608005082	DNA topoisomerase I; Validated; Region: PRK05582
717608005083	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
717608005084	active site
717608005085	interdomain interaction site; other site
717608005086	putative metal-binding site [ion binding]; other site
717608005087	nucleotide binding site [chemical binding]; other site
717608005088	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717608005089	domain I; other site
717608005090	DNA binding groove [nucleotide binding]
717608005091	phosphate binding site [ion binding]; other site
717608005092	domain II; other site
717608005093	domain III; other site
717608005094	nucleotide binding site [chemical binding]; other site
717608005095	catalytic site [active]
717608005096	domain IV; other site
717608005097	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
717608005098	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
717608005099	transcriptional repressor CodY; Validated; Region: PRK04158
717608005100	CodY GAF-like domain; Region: CodY; pfam06018
717608005101	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
717608005102	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
717608005103	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
717608005104	glutaminase active site [active]
717608005105	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
717608005106	dimer interface [polypeptide binding]; other site
717608005107	active site
717608005108	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
717608005109	dimer interface [polypeptide binding]; other site
717608005110	active site
717608005111	Rubrerythrin [Energy production and conversion]; Region: COG1592
717608005112	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
717608005113	binuclear metal center [ion binding]; other site
717608005114	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
717608005115	iron binding site [ion binding]; other site
717608005116	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
717608005117	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
717608005118	Walker A/P-loop; other site
717608005119	ATP binding site [chemical binding]; other site
717608005120	Q-loop/lid; other site
717608005121	ABC transporter signature motif; other site
717608005122	Walker B; other site
717608005123	D-loop; other site
717608005124	H-loop/switch region; other site
717608005125	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
717608005126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608005127	dimer interface [polypeptide binding]; other site
717608005128	conserved gate region; other site
717608005129	ABC-ATPase subunit interface; other site
717608005130	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
717608005131	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608005132	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
717608005133	metal binding site [ion binding]; metal-binding site
717608005134	putative dimer interface [polypeptide binding]; other site
717608005135	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
717608005136	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
717608005137	trimer interface [polypeptide binding]; other site
717608005138	active site
717608005139	substrate binding site [chemical binding]; other site
717608005140	CoA binding site [chemical binding]; other site
717608005141	Phosphopantetheine attachment site; Region: PP-binding; cl09936
717608005142	Transcription antiterminator [Transcription]; Region: NusG; COG0250
717608005143	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
717608005144	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
717608005145	putative nucleotide binding site [chemical binding]; other site
717608005146	uridine monophosphate binding site [chemical binding]; other site
717608005147	homohexameric interface [polypeptide binding]; other site
717608005148	ribosome recycling factor; Reviewed; Region: frr; PRK00083
717608005149	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
717608005150	hinge region; other site
717608005151	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
717608005152	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
717608005153	catalytic residue [active]
717608005154	putative FPP diphosphate  binding site; other site
717608005155	putative FPP binding hydrophobic cleft; other site
717608005156	dimer interface [polypeptide binding]; other site
717608005157	putative IPP diphosphate binding site; other site
717608005158	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
717608005159	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
717608005160	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
717608005161	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
717608005162	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
717608005163	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
717608005164	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
717608005165	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
717608005166	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
717608005167	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
717608005168	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
717608005169	generic binding surface II; other site
717608005170	generic binding surface I; other site
717608005171	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
717608005172	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
717608005173	active site
717608005174	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
717608005175	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
717608005176	active site
717608005177	catalytic site [active]
717608005178	substrate binding site [chemical binding]; other site
717608005179	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
717608005180	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
717608005181	DNA polymerase III PolC; Validated; Region: polC; PRK00448
717608005182	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
717608005183	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608005184	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608005185	homodimer interface [polypeptide binding]; other site
717608005186	catalytic residue [active]
717608005187	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
717608005188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608005189	active site
717608005190	phosphorylation site [posttranslational modification]
717608005191	intermolecular recognition site; other site
717608005192	dimerization interface [polypeptide binding]; other site
717608005193	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608005194	Zn2+ binding site [ion binding]; other site
717608005195	Mg2+ binding site [ion binding]; other site
717608005196	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
717608005197	putative binding surface; other site
717608005198	active site
717608005199	transcriptional antiterminator BglG; Provisional; Region: PRK09772
717608005200	CAT RNA binding domain; Region: CAT_RBD; smart01061
717608005201	PRD domain; Region: PRD; pfam00874
717608005202	PRD domain; Region: PRD; pfam00874
717608005203	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
717608005204	HPr interaction site; other site
717608005205	glycerol kinase (GK) interaction site [polypeptide binding]; other site
717608005206	active site
717608005207	phosphorylation site [posttranslational modification]
717608005208	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
717608005209	dimerization domain swap beta strand [polypeptide binding]; other site
717608005210	regulatory protein interface [polypeptide binding]; other site
717608005211	active site
717608005212	regulatory phosphorylation site [posttranslational modification]; other site
717608005213	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
717608005214	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717608005215	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
717608005216	active site turn [active]
717608005217	phosphorylation site [posttranslational modification]
717608005218	Type III pantothenate kinase; Region: Pan_kinase; cl17198
717608005219	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
717608005220	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
717608005221	acyl carrier protein; Provisional; Region: acpP; PRK00982
717608005222	ribonuclease III; Reviewed; Region: rnc; PRK00102
717608005223	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
717608005224	dimerization interface [polypeptide binding]; other site
717608005225	active site
717608005226	metal binding site [ion binding]; metal-binding site
717608005227	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
717608005228	dsRNA binding site [nucleotide binding]; other site
717608005229	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
717608005230	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
717608005231	Walker A/P-loop; other site
717608005232	ATP binding site [chemical binding]; other site
717608005233	Q-loop/lid; other site
717608005234	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
717608005235	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
717608005236	Q-loop/lid; other site
717608005237	ABC transporter signature motif; other site
717608005238	Walker B; other site
717608005239	D-loop; other site
717608005240	H-loop/switch region; other site
717608005241	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
717608005242	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
717608005243	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
717608005244	P loop; other site
717608005245	GTP binding site [chemical binding]; other site
717608005246	threonine dehydratase; Provisional; Region: PRK08198
717608005247	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
717608005248	tetramer interface [polypeptide binding]; other site
717608005249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608005250	catalytic residue [active]
717608005251	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
717608005252	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
717608005253	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
717608005254	Cl- selectivity filter; other site
717608005255	Cl- binding residues [ion binding]; other site
717608005256	pore gating glutamate residue; other site
717608005257	dimer interface [polypeptide binding]; other site
717608005258	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
717608005259	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
717608005260	active site
717608005261	putative substrate binding pocket [chemical binding]; other site
717608005262	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717608005263	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
717608005264	substrate binding site [chemical binding]; other site
717608005265	ATP binding site [chemical binding]; other site
717608005266	maltose O-acetyltransferase; Provisional; Region: PRK10092
717608005267	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
717608005268	active site
717608005269	substrate binding site [chemical binding]; other site
717608005270	trimer interface [polypeptide binding]; other site
717608005271	CoA binding site [chemical binding]; other site
717608005272	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608005273	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
717608005274	putative metal binding site [ion binding]; other site
717608005275	dimer interface [polypeptide binding]; other site
717608005276	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608005277	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
717608005278	catalytic residues [active]
717608005279	catalytic nucleophile [active]
717608005280	Recombinase; Region: Recombinase; pfam07508
717608005281	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608005282	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608005283	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
717608005284	DNA binding residues [nucleotide binding]
717608005285	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
717608005286	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717608005287	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608005288	Walker A/P-loop; other site
717608005289	ATP binding site [chemical binding]; other site
717608005290	Q-loop/lid; other site
717608005291	ABC transporter signature motif; other site
717608005292	Walker B; other site
717608005293	D-loop; other site
717608005294	H-loop/switch region; other site
717608005295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717608005296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608005297	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
717608005298	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717608005299	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
717608005300	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
717608005301	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717608005302	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
717608005303	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717608005304	NlpC/P60 family; Region: NLPC_P60; pfam00877
717608005305	PrgI family protein; Region: PrgI; pfam12666
717608005306	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717608005307	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608005308	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608005309	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608005310	putative catalytic residues [active]
717608005311	catalytic nucleophile [active]
717608005312	Recombinase; Region: Recombinase; pfam07508
717608005313	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608005314	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608005315	Virulence-associated protein E; Region: VirE; pfam05272
717608005316	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608005317	MobA/MobL family; Region: MobA_MobL; pfam03389
717608005318	SdpI/YhfL protein family; Region: SdpI; pfam13630
717608005319	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
717608005320	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608005321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608005322	non-specific DNA binding site [nucleotide binding]; other site
717608005323	salt bridge; other site
717608005324	sequence-specific DNA binding site [nucleotide binding]; other site
717608005325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608005326	salt bridge; other site
717608005327	non-specific DNA binding site [nucleotide binding]; other site
717608005328	sequence-specific DNA binding site [nucleotide binding]; other site
717608005329	Maff2 family; Region: Maff2; pfam12750
717608005330	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
717608005331	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608005332	Walker A motif; other site
717608005333	ATP binding site [chemical binding]; other site
717608005334	Walker B motif; other site
717608005335	Antirestriction protein (ArdA); Region: ArdA; pfam07275
717608005336	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
717608005337	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
717608005338	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
717608005339	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717608005340	dimerization interface [polypeptide binding]; other site
717608005341	putative DNA binding site [nucleotide binding]; other site
717608005342	putative Zn2+ binding site [ion binding]; other site
717608005343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
717608005344	Major Facilitator Superfamily; Region: MFS_1; pfam07690
717608005345	putative DNA-binding protein; Validated; Region: PRK00118
717608005346	signal recognition particle protein; Provisional; Region: PRK10867
717608005347	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
717608005348	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
717608005349	P loop; other site
717608005350	GTP binding site [chemical binding]; other site
717608005351	Signal peptide binding domain; Region: SRP_SPB; pfam02978
717608005352	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
717608005353	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
717608005354	hypothetical protein; Provisional; Region: PRK00468
717608005355	G-X-X-G motif; other site
717608005356	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
717608005357	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
717608005358	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608005359	motif II; other site
717608005360	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
717608005361	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
717608005362	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
717608005363	GTP/Mg2+ binding site [chemical binding]; other site
717608005364	G4 box; other site
717608005365	G5 box; other site
717608005366	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
717608005367	G1 box; other site
717608005368	G1 box; other site
717608005369	GTP/Mg2+ binding site [chemical binding]; other site
717608005370	Switch I region; other site
717608005371	G2 box; other site
717608005372	G2 box; other site
717608005373	G3 box; other site
717608005374	G3 box; other site
717608005375	Switch II region; other site
717608005376	Switch II region; other site
717608005377	G4 box; other site
717608005378	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
717608005379	RNA/DNA hybrid binding site [nucleotide binding]; other site
717608005380	active site
717608005381	hypothetical protein; Reviewed; Region: PRK12497
717608005382	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
717608005383	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
717608005384	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
717608005385	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
717608005386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608005387	S-adenosylmethionine binding site [chemical binding]; other site
717608005388	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
717608005389	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
717608005390	active site
717608005391	(T/H)XGH motif; other site
717608005392	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
717608005393	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
717608005394	Peptidase family M23; Region: Peptidase_M23; pfam01551
717608005395	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
717608005396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608005397	S-adenosylmethionine binding site [chemical binding]; other site
717608005398	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
717608005399	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
717608005400	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608005401	RNA binding surface [nucleotide binding]; other site
717608005402	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
717608005403	active site
717608005404	uracil binding [chemical binding]; other site
717608005405	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
717608005406	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
717608005407	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608005408	motif II; other site
717608005409	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
717608005410	hypothetical protein; Provisional; Region: PRK00955
717608005411	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
717608005412	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717608005413	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
717608005414	NAD(P) binding site [chemical binding]; other site
717608005415	active site
717608005416	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
717608005417	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608005418	RNA binding surface [nucleotide binding]; other site
717608005419	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
717608005420	active site
717608005421	Recombination protein U; Region: RecU; cl01314
717608005422	peptidase T; Region: peptidase-T; TIGR01882
717608005423	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
717608005424	metal binding site [ion binding]; metal-binding site
717608005425	dimer interface [polypeptide binding]; other site
717608005426	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
717608005427	active site
717608005428	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
717608005429	dimer interface [polypeptide binding]; other site
717608005430	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
717608005431	Ligand Binding Site [chemical binding]; other site
717608005432	Molecular Tunnel; other site
717608005433	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
717608005434	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
717608005435	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717608005436	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
717608005437	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
717608005438	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
717608005439	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717608005440	putative active site [active]
717608005441	putative metal binding site [ion binding]; other site
717608005442	Phosphopantetheine attachment site; Region: PP-binding; cl09936
717608005443	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
717608005444	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
717608005445	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
717608005446	active site
717608005447	catalytic triad [active]
717608005448	oxyanion hole [active]
717608005449	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
717608005450	AMP-binding enzyme; Region: AMP-binding; pfam00501
717608005451	acyl-activating enzyme (AAE) consensus motif; other site
717608005452	AMP binding site [chemical binding]; other site
717608005453	active site
717608005454	CoA binding site [chemical binding]; other site
717608005455	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717608005456	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
717608005457	putative ADP-binding pocket [chemical binding]; other site
717608005458	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
717608005459	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
717608005460	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
717608005461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717608005462	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
717608005463	NAD(P) binding site [chemical binding]; other site
717608005464	active site
717608005465	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
717608005466	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
717608005467	B12 binding site [chemical binding]; other site
717608005468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608005469	FeS/SAM binding site; other site
717608005470	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
717608005471	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
717608005472	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608005473	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
717608005474	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
717608005475	Protein of unknown function (DUF464); Region: DUF464; pfam04327
717608005476	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
717608005477	GTPase CgtA; Reviewed; Region: obgE; PRK12297
717608005478	GTP1/OBG; Region: GTP1_OBG; pfam01018
717608005479	Obg GTPase; Region: Obg; cd01898
717608005480	G1 box; other site
717608005481	GTP/Mg2+ binding site [chemical binding]; other site
717608005482	Switch I region; other site
717608005483	G2 box; other site
717608005484	G3 box; other site
717608005485	Switch II region; other site
717608005486	G4 box; other site
717608005487	G5 box; other site
717608005488	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
717608005489	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
717608005490	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
717608005491	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
717608005492	active site
717608005493	(T/H)XGH motif; other site
717608005494	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608005495	Zn2+ binding site [ion binding]; other site
717608005496	Mg2+ binding site [ion binding]; other site
717608005497	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
717608005498	LexA repressor; Validated; Region: PRK00215
717608005499	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
717608005500	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
717608005501	Catalytic site [active]
717608005502	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
717608005503	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
717608005504	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608005505	active site
717608005506	Int/Topo IB signature motif; other site
717608005507	DNA binding site [nucleotide binding]
717608005508	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
717608005509	Ligand Binding Site [chemical binding]; other site
717608005510	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
717608005511	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
717608005512	4Fe-4S binding domain; Region: Fer4; cl02805
717608005513	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717608005514	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
717608005515	putative ADP-ribose binding site [chemical binding]; other site
717608005516	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608005517	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
717608005518	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
717608005519	active site
717608005520	dimer interface [polypeptide binding]; other site
717608005521	metal binding site [ion binding]; metal-binding site
717608005522	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
717608005523	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608005524	RNA binding surface [nucleotide binding]; other site
717608005525	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
717608005526	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
717608005527	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
717608005528	substrate binding site [chemical binding]; other site
717608005529	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
717608005530	Septum formation topological specificity factor MinE; Region: MinE; cl00538
717608005531	septum site-determining protein MinD; Region: minD_bact; TIGR01968
717608005532	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
717608005533	Switch I; other site
717608005534	Switch II; other site
717608005535	septum formation inhibitor; Reviewed; Region: minC; PRK00513
717608005536	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
717608005537	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
717608005538	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
717608005539	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
717608005540	Aluminium resistance protein; Region: Alum_res; pfam06838
717608005541	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
717608005542	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
717608005543	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717608005544	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608005545	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
717608005546	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717608005547	Predicted permease; Region: DUF318; cl17795
717608005548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608005549	FeS/SAM binding site; other site
717608005550	TRAM domain; Region: TRAM; cl01282
717608005551	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
717608005552	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
717608005553	putative catalytic cysteine [active]
717608005554	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
717608005555	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
717608005556	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
717608005557	gamma-glutamyl kinase; Provisional; Region: PRK05429
717608005558	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
717608005559	nucleotide binding site [chemical binding]; other site
717608005560	homotetrameric interface [polypeptide binding]; other site
717608005561	putative phosphate binding site [ion binding]; other site
717608005562	putative allosteric binding site; other site
717608005563	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
717608005564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608005565	flavoprotein, HI0933 family; Region: TIGR00275
717608005566	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
717608005567	metal-binding heat shock protein; Provisional; Region: PRK00016
717608005568	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
717608005569	PhoH-like protein; Region: PhoH; pfam02562
717608005570	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
717608005571	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
717608005572	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
717608005573	Beta-Casp domain; Region: Beta-Casp; smart01027
717608005574	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
717608005575	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
717608005576	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
717608005577	Beta-Casp domain; Region: Beta-Casp; smart01027
717608005578	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
717608005579	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
717608005580	G1 box; other site
717608005581	GTP/Mg2+ binding site [chemical binding]; other site
717608005582	G2 box; other site
717608005583	Switch I region; other site
717608005584	G3 box; other site
717608005585	Switch II region; other site
717608005586	G5 box; other site
717608005587	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
717608005588	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
717608005589	Walker A/P-loop; other site
717608005590	ATP binding site [chemical binding]; other site
717608005591	Q-loop/lid; other site
717608005592	ABC transporter signature motif; other site
717608005593	Walker B; other site
717608005594	D-loop; other site
717608005595	H-loop/switch region; other site
717608005596	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
717608005597	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
717608005598	Walker A/P-loop; other site
717608005599	ATP binding site [chemical binding]; other site
717608005600	Q-loop/lid; other site
717608005601	ABC transporter signature motif; other site
717608005602	Walker B; other site
717608005603	D-loop; other site
717608005604	H-loop/switch region; other site
717608005605	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608005606	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
717608005607	TM-ABC transporter signature motif; other site
717608005608	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608005609	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
717608005610	TM-ABC transporter signature motif; other site
717608005611	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
717608005612	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
717608005613	putative ligand binding site [chemical binding]; other site
717608005614	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
717608005615	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
717608005616	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
717608005617	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
717608005618	GTP-binding protein Der; Reviewed; Region: PRK00093
717608005619	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
717608005620	G1 box; other site
717608005621	GTP/Mg2+ binding site [chemical binding]; other site
717608005622	Switch I region; other site
717608005623	G2 box; other site
717608005624	Switch II region; other site
717608005625	G3 box; other site
717608005626	G4 box; other site
717608005627	G5 box; other site
717608005628	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
717608005629	G1 box; other site
717608005630	GTP/Mg2+ binding site [chemical binding]; other site
717608005631	Switch I region; other site
717608005632	G2 box; other site
717608005633	G3 box; other site
717608005634	Switch II region; other site
717608005635	G4 box; other site
717608005636	G5 box; other site
717608005637	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
717608005638	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
717608005639	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608005640	active site
717608005641	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
717608005642	dimer interface [polypeptide binding]; other site
717608005643	catalytic triad [active]
717608005644	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
717608005645	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
717608005646	ssDNA binding site; other site
717608005647	generic binding surface II; other site
717608005648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608005649	ATP binding site [chemical binding]; other site
717608005650	putative Mg++ binding site [ion binding]; other site
717608005651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608005652	nucleotide binding region [chemical binding]; other site
717608005653	ATP-binding site [chemical binding]; other site
717608005654	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
717608005655	DAK2 domain; Region: Dak2; pfam02734
717608005656	Asp23 family; Region: Asp23; pfam03780
717608005657	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
717608005658	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
717608005659	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
717608005660	competence damage-inducible protein A; Provisional; Region: PRK00549
717608005661	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
717608005662	putative MPT binding site; other site
717608005663	Competence-damaged protein; Region: CinA; pfam02464
717608005664	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
717608005665	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
717608005666	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717608005667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608005668	FeS/SAM binding site; other site
717608005669	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
717608005670	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
717608005671	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
717608005672	catalytic site [active]
717608005673	G-X2-G-X-G-K; other site
717608005674	hypothetical protein; Provisional; Region: PRK11820
717608005675	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
717608005676	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
717608005677	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
717608005678	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
717608005679	citrate lyase subunit gamma; Provisional; Region: PRK13253
717608005680	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
717608005681	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
717608005682	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
717608005683	Domain of unknown function (DUF814); Region: DUF814; pfam05670
717608005684	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
717608005685	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
717608005686	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
717608005687	transmembrane helices; other site
717608005688	seryl-tRNA synthetase; Provisional; Region: PRK05431
717608005689	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
717608005690	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
717608005691	motif 1; other site
717608005692	dimer interface [polypeptide binding]; other site
717608005693	active site
717608005694	motif 2; other site
717608005695	motif 3; other site
717608005696	pyridoxamine kinase; Validated; Region: PRK05756
717608005697	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
717608005698	dimer interface [polypeptide binding]; other site
717608005699	pyridoxal binding site [chemical binding]; other site
717608005700	ATP binding site [chemical binding]; other site
717608005701	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
717608005702	Thiamine pyrophosphokinase; Region: TPK; cd07995
717608005703	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
717608005704	active site
717608005705	dimerization interface [polypeptide binding]; other site
717608005706	thiamine binding site [chemical binding]; other site
717608005707	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
717608005708	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
717608005709	substrate binding site [chemical binding]; other site
717608005710	hexamer interface [polypeptide binding]; other site
717608005711	metal binding site [ion binding]; metal-binding site
717608005712	GTPase RsgA; Reviewed; Region: PRK00098
717608005713	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
717608005714	RNA binding site [nucleotide binding]; other site
717608005715	homodimer interface [polypeptide binding]; other site
717608005716	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
717608005717	GTPase/Zn-binding domain interface [polypeptide binding]; other site
717608005718	GTP/Mg2+ binding site [chemical binding]; other site
717608005719	G4 box; other site
717608005720	G5 box; other site
717608005721	G1 box; other site
717608005722	Switch I region; other site
717608005723	G2 box; other site
717608005724	G3 box; other site
717608005725	Switch II region; other site
717608005726	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
717608005727	Catalytic domain of Protein Kinases; Region: PKc; cd00180
717608005728	active site
717608005729	ATP binding site [chemical binding]; other site
717608005730	substrate binding site [chemical binding]; other site
717608005731	activation loop (A-loop); other site
717608005732	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717608005733	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717608005734	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
717608005735	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
717608005736	active site
717608005737	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
717608005738	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608005739	FeS/SAM binding site; other site
717608005740	16S rRNA methyltransferase B; Provisional; Region: PRK14902
717608005741	NusB family; Region: NusB; pfam01029
717608005742	putative RNA binding site [nucleotide binding]; other site
717608005743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608005744	S-adenosylmethionine binding site [chemical binding]; other site
717608005745	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
717608005746	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
717608005747	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
717608005748	putative active site [active]
717608005749	substrate binding site [chemical binding]; other site
717608005750	putative cosubstrate binding site; other site
717608005751	catalytic site [active]
717608005752	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
717608005753	substrate binding site [chemical binding]; other site
717608005754	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
717608005755	active site
717608005756	catalytic residues [active]
717608005757	metal binding site [ion binding]; metal-binding site
717608005758	primosome assembly protein PriA; Validated; Region: PRK05580
717608005759	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
717608005760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608005761	ATP binding site [chemical binding]; other site
717608005762	putative Mg++ binding site [ion binding]; other site
717608005763	helicase superfamily c-terminal domain; Region: HELICc; smart00490
717608005764	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
717608005765	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717608005766	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717608005767	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717608005768	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
717608005769	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
717608005770	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717608005771	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717608005772	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
717608005773	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
717608005774	active site
717608005775	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
717608005776	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608005777	active site
717608005778	nucleotide binding site [chemical binding]; other site
717608005779	HIGH motif; other site
717608005780	KMSKS motif; other site
717608005781	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608005782	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608005783	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608005784	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608005785	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717608005786	NlpC/P60 family; Region: NLPC_P60; pfam00877
717608005787	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608005788	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
717608005789	TM-ABC transporter signature motif; other site
717608005790	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
717608005791	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608005792	zinc binding site [ion binding]; other site
717608005793	putative ligand binding site [chemical binding]; other site
717608005794	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608005795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608005796	dimer interface [polypeptide binding]; other site
717608005797	phosphorylation site [posttranslational modification]
717608005798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608005799	ATP binding site [chemical binding]; other site
717608005800	Mg2+ binding site [ion binding]; other site
717608005801	G-X-G motif; other site
717608005802	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608005803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608005804	active site
717608005805	phosphorylation site [posttranslational modification]
717608005806	intermolecular recognition site; other site
717608005807	dimerization interface [polypeptide binding]; other site
717608005808	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608005809	DNA binding site [nucleotide binding]
717608005810	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
717608005811	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717608005812	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717608005813	PhoU domain; Region: PhoU; pfam01895
717608005814	PhoU domain; Region: PhoU; pfam01895
717608005815	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
717608005816	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
717608005817	active site
717608005818	dimer interface [polypeptide binding]; other site
717608005819	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
717608005820	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
717608005821	active site
717608005822	nucleophile elbow; other site
717608005823	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
717608005824	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
717608005825	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
717608005826	putative active site [active]
717608005827	catalytic site [active]
717608005828	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
717608005829	putative active site [active]
717608005830	catalytic site [active]
717608005831	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
717608005832	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
717608005833	homodimer interface [polypeptide binding]; other site
717608005834	substrate-cofactor binding pocket; other site
717608005835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608005836	catalytic residue [active]
717608005837	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
717608005838	putative active site [active]
717608005839	putative metal binding site [ion binding]; other site
717608005840	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
717608005841	putative active site [active]
717608005842	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
717608005843	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
717608005844	Protein of unknown function, DUF624; Region: DUF624; pfam04854
717608005845	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
717608005846	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
717608005847	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
717608005848	Walker A/P-loop; other site
717608005849	ATP binding site [chemical binding]; other site
717608005850	Q-loop/lid; other site
717608005851	ABC transporter signature motif; other site
717608005852	Walker B; other site
717608005853	D-loop; other site
717608005854	H-loop/switch region; other site
717608005855	TOBE domain; Region: TOBE_2; pfam08402
717608005856	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
717608005857	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
717608005858	DNA binding site [nucleotide binding]
717608005859	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
717608005860	putative ligand binding site [chemical binding]; other site
717608005861	putative dimerization interface [polypeptide binding]; other site
717608005862	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
717608005863	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
717608005864	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
717608005865	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
717608005866	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
717608005867	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
717608005868	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
717608005869	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
717608005870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608005871	dimer interface [polypeptide binding]; other site
717608005872	conserved gate region; other site
717608005873	putative PBP binding loops; other site
717608005874	ABC-ATPase subunit interface; other site
717608005875	Predicted transcriptional regulators [Transcription]; Region: COG1733
717608005876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717608005877	dimerization interface [polypeptide binding]; other site
717608005878	putative DNA binding site [nucleotide binding]; other site
717608005879	putative Zn2+ binding site [ion binding]; other site
717608005880	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
717608005881	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
717608005882	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
717608005883	Uncharacterized conserved protein [Function unknown]; Region: COG2006
717608005884	4Fe-4S binding domain; Region: Fer4; pfam00037
717608005885	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717608005886	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
717608005887	Walker A/P-loop; other site
717608005888	ATP binding site [chemical binding]; other site
717608005889	Q-loop/lid; other site
717608005890	ABC transporter signature motif; other site
717608005891	Walker B; other site
717608005892	D-loop; other site
717608005893	H-loop/switch region; other site
717608005894	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
717608005895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608005896	dimer interface [polypeptide binding]; other site
717608005897	conserved gate region; other site
717608005898	putative PBP binding loops; other site
717608005899	ABC-ATPase subunit interface; other site
717608005900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608005901	dimer interface [polypeptide binding]; other site
717608005902	conserved gate region; other site
717608005903	putative PBP binding loops; other site
717608005904	ABC-ATPase subunit interface; other site
717608005905	hypothetical protein; Provisional; Region: PRK11622
717608005906	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
717608005907	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
717608005908	active site residue [active]
717608005909	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
717608005910	active site residue [active]
717608005911	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
717608005912	active site residue [active]
717608005913	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
717608005914	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
717608005915	active site residue [active]
717608005916	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
717608005917	active site residue [active]
717608005918	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
717608005919	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
717608005920	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
717608005921	Probable Catalytic site; other site
717608005922	Uncharacterized conserved protein [Function unknown]; Region: COG0398
717608005923	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
717608005924	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
717608005925	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608005926	Cysteine-rich domain; Region: CCG; pfam02754
717608005927	Uncharacterized conserved protein [Function unknown]; Region: COG0398
717608005928	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
717608005929	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
717608005930	dimerization interface [polypeptide binding]; other site
717608005931	putative ATP binding site [chemical binding]; other site
717608005932	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
717608005933	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
717608005934	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
717608005935	propionate/acetate kinase; Provisional; Region: PRK12379
717608005936	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
717608005937	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
717608005938	hypothetical protein; Provisional; Region: PRK13670
717608005939	Methyltransferase domain; Region: Methyltransf_31; pfam13847
717608005940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608005941	S-adenosylmethionine binding site [chemical binding]; other site
717608005942	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
717608005943	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
717608005944	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
717608005945	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
717608005946	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
717608005947	CoA-binding site [chemical binding]; other site
717608005948	ATP-binding [chemical binding]; other site
717608005949	5'-3' exonuclease; Region: 53EXOc; smart00475
717608005950	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
717608005951	active site
717608005952	metal binding site 1 [ion binding]; metal-binding site
717608005953	putative 5' ssDNA interaction site; other site
717608005954	metal binding site 3; metal-binding site
717608005955	metal binding site 2 [ion binding]; metal-binding site
717608005956	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
717608005957	putative DNA binding site [nucleotide binding]; other site
717608005958	putative metal binding site [ion binding]; other site
717608005959	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
717608005960	DNA polymerase I; Provisional; Region: PRK05755
717608005961	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
717608005962	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
717608005963	active site
717608005964	DNA binding site [nucleotide binding]
717608005965	catalytic site [active]
717608005966	Putative zinc-finger; Region: zf-HC2; pfam13490
717608005967	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
717608005968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
717608005969	active site
717608005970	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
717608005971	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
717608005972	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717608005973	active site
717608005974	putative interdomain interaction site [polypeptide binding]; other site
717608005975	putative metal-binding site [ion binding]; other site
717608005976	putative nucleotide binding site [chemical binding]; other site
717608005977	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
717608005978	domain I; other site
717608005979	DNA binding groove [nucleotide binding]
717608005980	phosphate binding site [ion binding]; other site
717608005981	domain II; other site
717608005982	domain III; other site
717608005983	nucleotide binding site [chemical binding]; other site
717608005984	catalytic site [active]
717608005985	domain IV; other site
717608005986	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
717608005987	active site
717608005988	catalytic residues [active]
717608005989	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
717608005990	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
717608005991	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
717608005992	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608005993	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
717608005994	active site
717608005995	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
717608005996	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
717608005997	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
717608005998	ligand binding site [chemical binding]; other site
717608005999	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608006000	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717608006001	TM-ABC transporter signature motif; other site
717608006002	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608006003	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
717608006004	TM-ABC transporter signature motif; other site
717608006005	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
717608006006	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717608006007	Walker A/P-loop; other site
717608006008	ATP binding site [chemical binding]; other site
717608006009	Q-loop/lid; other site
717608006010	ABC transporter signature motif; other site
717608006011	Walker B; other site
717608006012	D-loop; other site
717608006013	H-loop/switch region; other site
717608006014	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717608006015	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
717608006016	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
717608006017	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608006018	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717608006019	metal binding site [ion binding]; metal-binding site
717608006020	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
717608006021	primary dimer interface [polypeptide binding]; other site
717608006022	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608006023	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
717608006024	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
717608006025	CAP-like domain; other site
717608006026	active site
717608006027	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
717608006028	putative metal binding site; other site
717608006029	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
717608006030	putative homodimer interface [polypeptide binding]; other site
717608006031	putative homotetramer interface [polypeptide binding]; other site
717608006032	putative allosteric switch controlling residues; other site
717608006033	putative metal binding site [ion binding]; other site
717608006034	putative homodimer-homodimer interface [polypeptide binding]; other site
717608006035	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717608006036	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
717608006037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608006038	FeS/SAM binding site; other site
717608006039	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
717608006040	substrate binding pocket [chemical binding]; other site
717608006041	enolase; Provisional; Region: eno; PRK00077
717608006042	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
717608006043	dimer interface [polypeptide binding]; other site
717608006044	metal binding site [ion binding]; metal-binding site
717608006045	peroxiredoxin; Region: AhpC; TIGR03137
717608006046	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
717608006047	dimer interface [polypeptide binding]; other site
717608006048	decamer (pentamer of dimers) interface [polypeptide binding]; other site
717608006049	catalytic triad [active]
717608006050	peroxidatic and resolving cysteines [active]
717608006051	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608006052	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608006053	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608006054	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
717608006055	Walker A/P-loop; other site
717608006056	ATP binding site [chemical binding]; other site
717608006057	Q-loop/lid; other site
717608006058	ABC transporter signature motif; other site
717608006059	Walker B; other site
717608006060	D-loop; other site
717608006061	H-loop/switch region; other site
717608006062	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717608006063	MarR family; Region: MarR_2; pfam12802
717608006064	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608006065	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
717608006066	FtsX-like permease family; Region: FtsX; pfam02687
717608006067	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608006068	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608006069	Walker A/P-loop; other site
717608006070	ATP binding site [chemical binding]; other site
717608006071	Q-loop/lid; other site
717608006072	ABC transporter signature motif; other site
717608006073	Walker B; other site
717608006074	D-loop; other site
717608006075	H-loop/switch region; other site
717608006076	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
717608006077	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
717608006078	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
717608006079	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
717608006080	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
717608006081	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
717608006082	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
717608006083	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
717608006084	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
717608006085	active site
717608006086	Uncharacterized conserved protein [Function unknown]; Region: COG0327
717608006087	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
717608006088	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
717608006089	Family of unknown function (DUF633); Region: DUF633; pfam04816
717608006090	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
717608006091	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
717608006092	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608006093	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717608006094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608006095	DNA binding residues [nucleotide binding]
717608006096	DNA primase; Validated; Region: dnaG; PRK05667
717608006097	CHC2 zinc finger; Region: zf-CHC2; pfam01807
717608006098	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
717608006099	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
717608006100	active site
717608006101	metal binding site [ion binding]; metal-binding site
717608006102	interdomain interaction site; other site
717608006103	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
717608006104	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
717608006105	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608006106	Zn2+ binding site [ion binding]; other site
717608006107	Mg2+ binding site [ion binding]; other site
717608006108	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
717608006109	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
717608006110	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
717608006111	active site
717608006112	catalytic triad [active]
717608006113	Uncharacterized conserved protein [Function unknown]; Region: COG2966
717608006114	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
717608006115	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
717608006116	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
717608006117	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
717608006118	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
717608006119	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
717608006120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608006121	Walker A/P-loop; other site
717608006122	ATP binding site [chemical binding]; other site
717608006123	Q-loop/lid; other site
717608006124	ABC transporter signature motif; other site
717608006125	Walker B; other site
717608006126	D-loop; other site
717608006127	H-loop/switch region; other site
717608006128	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
717608006129	23S rRNA binding site [nucleotide binding]; other site
717608006130	L21 binding site [polypeptide binding]; other site
717608006131	L13 binding site [polypeptide binding]; other site
717608006132	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
717608006133	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
717608006134	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
717608006135	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
717608006136	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
717608006137	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
717608006138	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
717608006139	active site
717608006140	dimer interface [polypeptide binding]; other site
717608006141	motif 1; other site
717608006142	motif 2; other site
717608006143	motif 3; other site
717608006144	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
717608006145	anticodon binding site; other site
717608006146	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
717608006147	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
717608006148	homodimer interface [polypeptide binding]; other site
717608006149	substrate-cofactor binding pocket; other site
717608006150	catalytic residue [active]
717608006151	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608006152	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608006153	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
717608006154	SmpB-tmRNA interface; other site
717608006155	Preprotein translocase SecG subunit; Region: SecG; pfam03840
717608006156	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
717608006157	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
717608006158	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
717608006159	putative tRNA-binding site [nucleotide binding]; other site
717608006160	B3/4 domain; Region: B3_4; pfam03483
717608006161	tRNA synthetase B5 domain; Region: B5; pfam03484
717608006162	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
717608006163	dimer interface [polypeptide binding]; other site
717608006164	motif 1; other site
717608006165	motif 3; other site
717608006166	motif 2; other site
717608006167	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
717608006168	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
717608006169	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
717608006170	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
717608006171	dimer interface [polypeptide binding]; other site
717608006172	motif 1; other site
717608006173	active site
717608006174	motif 2; other site
717608006175	motif 3; other site
717608006176	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
717608006177	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
717608006178	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
717608006179	hypothetical protein; Reviewed; Region: PRK09588
717608006180	WYL domain; Region: WYL; pfam13280
717608006181	WYL domain; Region: WYL; pfam13280
717608006182	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
717608006183	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
717608006184	active site
717608006185	homodimer interface [polypeptide binding]; other site
717608006186	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
717608006187	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
717608006188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717608006189	NAD(P) binding site [chemical binding]; other site
717608006190	active site
717608006191	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608006192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608006193	S-adenosylmethionine binding site [chemical binding]; other site
717608006194	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608006195	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
717608006196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608006197	active site
717608006198	phosphorylation site [posttranslational modification]
717608006199	intermolecular recognition site; other site
717608006200	dimerization interface [polypeptide binding]; other site
717608006201	HTH domain; Region: HTH_11; cl17392
717608006202	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
717608006203	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
717608006204	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
717608006205	Phosphoglycerate kinase; Region: PGK; pfam00162
717608006206	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
717608006207	substrate binding site [chemical binding]; other site
717608006208	hinge regions; other site
717608006209	ADP binding site [chemical binding]; other site
717608006210	catalytic site [active]
717608006211	triosephosphate isomerase; Provisional; Region: PRK14567
717608006212	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
717608006213	substrate binding site [chemical binding]; other site
717608006214	dimer interface [polypeptide binding]; other site
717608006215	catalytic triad [active]
717608006216	Isochorismatase family; Region: Isochorismatase; pfam00857
717608006217	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
717608006218	catalytic triad [active]
717608006219	conserved cis-peptide bond; other site
717608006220	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
717608006221	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
717608006222	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
717608006223	phosphoglyceromutase; Provisional; Region: PRK05434
717608006224	EDD domain protein, DegV family; Region: DegV; TIGR00762
717608006225	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
717608006226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608006227	dimer interface [polypeptide binding]; other site
717608006228	phosphorylation site [posttranslational modification]
717608006229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608006230	ATP binding site [chemical binding]; other site
717608006231	Mg2+ binding site [ion binding]; other site
717608006232	G-X-G motif; other site
717608006233	Sporulation and spore germination; Region: Germane; pfam10646
717608006234	Sporulation and spore germination; Region: Germane; pfam10646
717608006235	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
717608006236	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
717608006237	Competence protein; Region: Competence; pfam03772
717608006238	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608006239	Flavodoxin domain; Region: Flavodoxin_5; cl17428
717608006240	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717608006241	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717608006242	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
717608006243	SWIM zinc finger; Region: SWIM; pfam04434
717608006244	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
717608006245	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
717608006246	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608006247	ATP binding site [chemical binding]; other site
717608006248	putative Mg++ binding site [ion binding]; other site
717608006249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608006250	nucleotide binding region [chemical binding]; other site
717608006251	ATP-binding site [chemical binding]; other site
717608006252	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
717608006253	germination protease; Provisional; Region: PRK12362
717608006254	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
717608006255	stage II sporulation protein P; Region: spore_II_P; TIGR02867
717608006256	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
717608006257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608006258	FeS/SAM binding site; other site
717608006259	HemN C-terminal domain; Region: HemN_C; pfam06969
717608006260	hypothetical protein; Provisional; Region: PRK10621
717608006261	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
717608006262	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
717608006263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608006264	S-adenosylmethionine binding site [chemical binding]; other site
717608006265	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
717608006266	RNA methyltransferase, RsmE family; Region: TIGR00046
717608006267	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
717608006268	regulatory protein interface [polypeptide binding]; other site
717608006269	regulatory phosphorylation site [posttranslational modification]; other site
717608006270	Predicted amidohydrolase [General function prediction only]; Region: COG0388
717608006271	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
717608006272	active site
717608006273	catalytic triad [active]
717608006274	dimer interface [polypeptide binding]; other site
717608006275	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
717608006276	Predicted amidohydrolase [General function prediction only]; Region: COG0388
717608006277	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
717608006278	active site
717608006279	catalytic triad [active]
717608006280	dimer interface [polypeptide binding]; other site
717608006281	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
717608006282	LemA family; Region: LemA; cl00742
717608006283	LemA family; Region: LemA; cl00742
717608006284	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
717608006285	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
717608006286	Helix-turn-helix domain; Region: HTH_36; pfam13730
717608006287	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
717608006288	Walker A motif; other site
717608006289	ATP binding site [chemical binding]; other site
717608006290	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608006291	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608006292	putative catalytic residues [active]
717608006293	catalytic nucleophile [active]
717608006294	Recombinase; Region: Recombinase; pfam07508
717608006295	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608006296	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608006297	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608006298	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608006299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608006300	active site
717608006301	phosphorylation site [posttranslational modification]
717608006302	intermolecular recognition site; other site
717608006303	dimerization interface [polypeptide binding]; other site
717608006304	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608006305	DNA binding site [nucleotide binding]
717608006306	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717608006307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608006308	Walker A/P-loop; other site
717608006309	ATP binding site [chemical binding]; other site
717608006310	Q-loop/lid; other site
717608006311	ABC transporter signature motif; other site
717608006312	Walker B; other site
717608006313	D-loop; other site
717608006314	H-loop/switch region; other site
717608006315	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
717608006316	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
717608006317	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608006318	DNA binding residues [nucleotide binding]
717608006319	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608006320	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608006321	DNA binding residues [nucleotide binding]
717608006322	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608006323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608006324	DNA binding residues [nucleotide binding]
717608006325	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
717608006326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
717608006327	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
717608006328	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
717608006329	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
717608006330	hypothetical protein; Validated; Region: PRK08116
717608006331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608006332	Walker A motif; other site
717608006333	ATP binding site [chemical binding]; other site
717608006334	Walker B motif; other site
717608006335	arginine finger; other site
717608006336	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608006337	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
717608006338	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
717608006339	Maff2 family; Region: Maff2; pfam12750
717608006340	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608006341	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608006342	T-DNA border endonuclease VirD1; Region: VirD1; cl17530
717608006343	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608006344	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
717608006345	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
717608006346	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
717608006347	hypothetical protein; Validated; Region: PRK08116
717608006348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608006349	Walker A motif; other site
717608006350	ATP binding site [chemical binding]; other site
717608006351	Walker B motif; other site
717608006352	arginine finger; other site
717608006353	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608006354	Cupin domain; Region: Cupin_2; pfam07883
717608006355	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608006356	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608006357	putative catalytic residues [active]
717608006358	catalytic nucleophile [active]
717608006359	Recombinase; Region: Recombinase; pfam07508
717608006360	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608006361	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608006362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608006363	AAA domain; Region: AAA_22; pfam13401
717608006364	Walker A motif; other site
717608006365	ATP binding site [chemical binding]; other site
717608006366	Walker B motif; other site
717608006367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
717608006368	Integrase core domain; Region: rve; pfam00665
717608006369	PrgI family protein; Region: PrgI; pfam12666
717608006370	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
717608006371	DNA methylase; Region: N6_N4_Mtase; cl17433
717608006372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608006373	S-adenosylmethionine binding site [chemical binding]; other site
717608006374	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
717608006375	hypothetical protein; Provisional; Region: PRK08557
717608006376	Ligand Binding Site [chemical binding]; other site
717608006377	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
717608006378	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
717608006379	DNA topoisomerase III; Provisional; Region: PRK07726
717608006380	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
717608006381	active site
717608006382	putative interdomain interaction site [polypeptide binding]; other site
717608006383	putative metal-binding site [ion binding]; other site
717608006384	putative nucleotide binding site [chemical binding]; other site
717608006385	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
717608006386	domain I; other site
717608006387	DNA binding groove [nucleotide binding]
717608006388	phosphate binding site [ion binding]; other site
717608006389	domain II; other site
717608006390	domain III; other site
717608006391	nucleotide binding site [chemical binding]; other site
717608006392	catalytic site [active]
717608006393	domain IV; other site
717608006394	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
717608006395	Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194
717608006396	Antirestriction protein (ArdA); Region: ArdA; cl01953
717608006397	Domain of unknown function (DUF955); Region: DUF955; cl01076
717608006398	YodL-like; Region: YodL; pfam14191
717608006399	Domain of unknown function (DUF4316); Region: DUF4316; pfam14195
717608006400	Domain of unknown function (DUF4319); Region: DUF4319; pfam14203
717608006401	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
717608006402	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
717608006403	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
717608006404	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608006405	FeS/SAM binding site; other site
717608006406	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608006407	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
717608006408	DNA binding residues [nucleotide binding]
717608006409	Helix-turn-helix domain; Region: HTH_16; pfam12645
717608006410	Transposon-encoded protein TnpW; Region: TnpW; pfam14202
717608006411	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608006412	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
717608006413	putative catalytic residues [active]
717608006414	catalytic nucleophile [active]
717608006415	Recombinase; Region: Recombinase; pfam07508
717608006416	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608006417	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
717608006418	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
717608006419	catalytic nucleophile [active]
717608006420	Virulence-associated protein E; Region: VirE; pfam05272
717608006421	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608006422	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608006423	non-specific DNA binding site [nucleotide binding]; other site
717608006424	salt bridge; other site
717608006425	sequence-specific DNA binding site [nucleotide binding]; other site
717608006426	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
717608006427	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608006428	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
717608006429	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608006430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608006431	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608006432	dimerization interface [polypeptide binding]; other site
717608006433	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
717608006434	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
717608006435	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608006436	FeS/SAM binding site; other site
717608006437	hypothetical protein; Provisional; Region: PRK05473
717608006438	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
717608006439	YceG-like family; Region: YceG; pfam02618
717608006440	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
717608006441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608006442	S-adenosylmethionine binding site [chemical binding]; other site
717608006443	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
717608006444	Peptidase family U32; Region: Peptidase_U32; pfam01136
717608006445	Uncharacterized conserved protein [Function unknown]; Region: COG1434
717608006446	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
717608006447	putative active site [active]
717608006448	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
717608006449	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
717608006450	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
717608006451	Peptidase M16C associated; Region: M16C_assoc; pfam08367
717608006452	GTPase Era; Reviewed; Region: era; PRK00089
717608006453	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
717608006454	G1 box; other site
717608006455	GTP/Mg2+ binding site [chemical binding]; other site
717608006456	Switch I region; other site
717608006457	G2 box; other site
717608006458	Switch II region; other site
717608006459	G3 box; other site
717608006460	G4 box; other site
717608006461	G5 box; other site
717608006462	glycyl-tRNA synthetase; Provisional; Region: PRK04173
717608006463	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
717608006464	motif 1; other site
717608006465	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
717608006466	active site
717608006467	motif 2; other site
717608006468	motif 3; other site
717608006469	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
717608006470	anticodon binding site; other site
717608006471	S-layer homology domain; Region: SLH; pfam00395
717608006472	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
717608006473	E3 interaction surface; other site
717608006474	HlyD family secretion protein; Region: HlyD_3; pfam13437
717608006475	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
717608006476	HlyD family secretion protein; Region: HlyD_3; pfam13437
717608006477	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608006478	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
717608006479	Walker A/P-loop; other site
717608006480	ATP binding site [chemical binding]; other site
717608006481	Q-loop/lid; other site
717608006482	ABC transporter signature motif; other site
717608006483	Walker B; other site
717608006484	D-loop; other site
717608006485	H-loop/switch region; other site
717608006486	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
717608006487	FtsX-like permease family; Region: FtsX; pfam02687
717608006488	pyruvate phosphate dikinase; Provisional; Region: PRK09279
717608006489	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
717608006490	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
717608006491	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
717608006492	Transcriptional regulators [Transcription]; Region: GntR; COG1802
717608006493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608006494	DNA-binding site [nucleotide binding]; DNA binding site
717608006495	FCD domain; Region: FCD; pfam07729
717608006496	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
717608006497	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608006498	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608006499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
717608006500	dimerization interface [polypeptide binding]; other site
717608006501	Histidine kinase; Region: His_kinase; pfam06580
717608006502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608006503	ATP binding site [chemical binding]; other site
717608006504	Mg2+ binding site [ion binding]; other site
717608006505	G-X-G motif; other site
717608006506	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
717608006507	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608006508	putative ligand binding site [chemical binding]; other site
717608006509	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
717608006510	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717608006511	Walker A/P-loop; other site
717608006512	ATP binding site [chemical binding]; other site
717608006513	Q-loop/lid; other site
717608006514	ABC transporter signature motif; other site
717608006515	Walker B; other site
717608006516	D-loop; other site
717608006517	H-loop/switch region; other site
717608006518	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717608006519	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608006520	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717608006521	TM-ABC transporter signature motif; other site
717608006522	L-arabinose isomerase; Provisional; Region: PRK02929
717608006523	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
717608006524	hexamer (dimer of trimers) interface [polypeptide binding]; other site
717608006525	trimer interface [polypeptide binding]; other site
717608006526	substrate binding site [chemical binding]; other site
717608006527	Mn binding site [ion binding]; other site
717608006528	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
717608006529	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
717608006530	putative N- and C-terminal domain interface [polypeptide binding]; other site
717608006531	putative active site [active]
717608006532	MgATP binding site [chemical binding]; other site
717608006533	catalytic site [active]
717608006534	metal binding site [ion binding]; metal-binding site
717608006535	putative carbohydrate binding site [chemical binding]; other site
717608006536	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
717608006537	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
717608006538	intersubunit interface [polypeptide binding]; other site
717608006539	active site
717608006540	Zn2+ binding site [ion binding]; other site
717608006541	ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040
717608006542	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608006543	metal binding site [ion binding]; metal-binding site
717608006544	active site
717608006545	I-site; other site
717608006546	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
717608006547	Rubrerythrin [Energy production and conversion]; Region: COG1592
717608006548	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
717608006549	binuclear metal center [ion binding]; other site
717608006550	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
717608006551	iron binding site [ion binding]; other site
717608006552	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
717608006553	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
717608006554	putative active site [active]
717608006555	putative metal binding site [ion binding]; other site
717608006556	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
717608006557	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
717608006558	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
717608006559	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
717608006560	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
717608006561	putative L-serine binding site [chemical binding]; other site
717608006562	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
717608006563	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
717608006564	ScpA/B protein; Region: ScpA_ScpB; cl00598
717608006565	ScpA/B protein; Region: ScpA_ScpB; cl00598
717608006566	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
717608006567	ATP cone domain; Region: ATP-cone; pfam03477
717608006568	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
717608006569	Class III ribonucleotide reductase; Region: RNR_III; cd01675
717608006570	effector binding site; other site
717608006571	active site
717608006572	Zn binding site [ion binding]; other site
717608006573	glycine loop; other site
717608006574	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
717608006575	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608006576	FeS/SAM binding site; other site
717608006577	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
717608006578	trimer interface [polypeptide binding]; other site
717608006579	active site
717608006580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608006581	TPR motif; other site
717608006582	binding surface
717608006583	TPR repeat; Region: TPR_11; pfam13414
717608006584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
717608006585	binding surface
717608006586	TPR motif; other site
717608006587	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
717608006588	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
717608006589	HflX GTPase family; Region: HflX; cd01878
717608006590	G1 box; other site
717608006591	GTP/Mg2+ binding site [chemical binding]; other site
717608006592	Switch I region; other site
717608006593	G2 box; other site
717608006594	G3 box; other site
717608006595	Switch II region; other site
717608006596	G4 box; other site
717608006597	G5 box; other site
717608006598	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717608006599	Na2 binding site [ion binding]; other site
717608006600	putative substrate binding site 1 [chemical binding]; other site
717608006601	Na binding site 1 [ion binding]; other site
717608006602	putative substrate binding site 2 [chemical binding]; other site
717608006603	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
717608006604	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
717608006605	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
717608006606	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
717608006607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608006608	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
717608006609	Walker A/P-loop; other site
717608006610	ATP binding site [chemical binding]; other site
717608006611	Q-loop/lid; other site
717608006612	ABC transporter signature motif; other site
717608006613	Walker B; other site
717608006614	D-loop; other site
717608006615	H-loop/switch region; other site
717608006616	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
717608006617	Part of AAA domain; Region: AAA_19; pfam13245
717608006618	Family description; Region: UvrD_C_2; pfam13538
717608006619	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
717608006620	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608006621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
717608006622	ATP binding site [chemical binding]; other site
717608006623	putative Mg++ binding site [ion binding]; other site
717608006624	Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564
717608006625	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
717608006626	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608006627	DNA methylase; Region: N6_N4_Mtase; pfam01555
717608006628	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
717608006629	non-specific DNA binding site [nucleotide binding]; other site
717608006630	salt bridge; other site
717608006631	sequence-specific DNA binding site [nucleotide binding]; other site
717608006632	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
717608006633	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608006634	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
717608006635	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
717608006636	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608006637	non-specific DNA binding site [nucleotide binding]; other site
717608006638	salt bridge; other site
717608006639	sequence-specific DNA binding site [nucleotide binding]; other site
717608006640	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608006641	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
717608006642	Virulence protein [General function prediction only]; Region: COG3943
717608006643	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
717608006644	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
717608006645	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
717608006646	catalytic residues [active]
717608006647	catalytic nucleophile [active]
717608006648	Recombinase; Region: Recombinase; pfam07508
717608006649	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
717608006650	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
717608006651	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
717608006652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
717608006653	catalytic residue [active]
717608006654	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
717608006655	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608006656	motif II; other site
717608006657	Protein of unknown function (DUF970); Region: DUF970; cl17525
717608006658	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717608006659	Na2 binding site [ion binding]; other site
717608006660	putative substrate binding site 1 [chemical binding]; other site
717608006661	Na binding site 1 [ion binding]; other site
717608006662	putative substrate binding site 2 [chemical binding]; other site
717608006663	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
717608006664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608006665	motif II; other site
717608006666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608006667	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608006668	Walker A/P-loop; other site
717608006669	ATP binding site [chemical binding]; other site
717608006670	Q-loop/lid; other site
717608006671	ABC transporter signature motif; other site
717608006672	Walker B; other site
717608006673	D-loop; other site
717608006674	H-loop/switch region; other site
717608006675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
717608006676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
717608006677	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
717608006678	MarR family; Region: MarR_2; pfam12802
717608006679	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
717608006680	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
717608006681	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717608006682	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
717608006683	PhoU domain; Region: PhoU; pfam01895
717608006684	PhoU domain; Region: PhoU; pfam01895
717608006685	stage V sporulation protein B; Region: spore_V_B; TIGR02900
717608006686	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
717608006687	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608006688	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608006689	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
717608006690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
717608006691	putative metal binding site [ion binding]; other site
717608006692	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717608006693	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717608006694	substrate binding pocket [chemical binding]; other site
717608006695	membrane-bound complex binding site; other site
717608006696	hinge residues; other site
717608006697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608006698	dimer interface [polypeptide binding]; other site
717608006699	conserved gate region; other site
717608006700	putative PBP binding loops; other site
717608006701	ABC-ATPase subunit interface; other site
717608006702	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
717608006703	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
717608006704	Walker A/P-loop; other site
717608006705	ATP binding site [chemical binding]; other site
717608006706	Q-loop/lid; other site
717608006707	ABC transporter signature motif; other site
717608006708	Walker B; other site
717608006709	D-loop; other site
717608006710	H-loop/switch region; other site
717608006711	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
717608006712	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
717608006713	putative metal binding site [ion binding]; other site
717608006714	phosphopentomutase; Provisional; Region: PRK05362
717608006715	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
717608006716	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
717608006717	intersubunit interface [polypeptide binding]; other site
717608006718	active site
717608006719	catalytic residue [active]
717608006720	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
717608006721	active site
717608006722	NTP binding site [chemical binding]; other site
717608006723	metal binding triad [ion binding]; metal-binding site
717608006724	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
717608006725	Predicted transcriptional regulators [Transcription]; Region: COG1725
717608006726	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608006727	DNA-binding site [nucleotide binding]; DNA binding site
717608006728	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608006729	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
717608006730	Walker A/P-loop; other site
717608006731	ATP binding site [chemical binding]; other site
717608006732	Q-loop/lid; other site
717608006733	ABC transporter signature motif; other site
717608006734	Walker B; other site
717608006735	D-loop; other site
717608006736	H-loop/switch region; other site
717608006737	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
717608006738	AsnC family; Region: AsnC_trans_reg; pfam01037
717608006739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608006740	salt bridge; other site
717608006741	non-specific DNA binding site [nucleotide binding]; other site
717608006742	sequence-specific DNA binding site [nucleotide binding]; other site
717608006743	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
717608006744	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
717608006745	putative DNA binding site [nucleotide binding]; other site
717608006746	putative Zn2+ binding site [ion binding]; other site
717608006747	AsnC family; Region: AsnC_trans_reg; pfam01037
717608006748	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608006749	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608006750	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
717608006751	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
717608006752	Acyltransferase family; Region: Acyl_transf_3; pfam01757
717608006753	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
717608006754	Bacterial sugar transferase; Region: Bac_transf; cl00939
717608006755	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
717608006756	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608006757	active site
717608006758	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608006759	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608006760	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608006761	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608006762	Transcriptional regulator [Transcription]; Region: LytR; COG1316
717608006763	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
717608006764	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
717608006765	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
717608006766	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608006767	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
717608006768	active site
717608006769	DNA binding site [nucleotide binding]
717608006770	Int/Topo IB signature motif; other site
717608006771	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
717608006772	active site
717608006773	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
717608006774	active site
717608006775	catalytic residues [active]
717608006776	FMN-binding domain; Region: FMN_bind; pfam04205
717608006777	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
717608006778	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
717608006779	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
717608006780	active site
717608006781	metal binding site [ion binding]; metal-binding site
717608006782	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
717608006783	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717608006784	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
717608006785	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
717608006786	4Fe-4S binding domain; Region: Fer4; cl02805
717608006787	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
717608006788	electron transport complex RsxE subunit; Provisional; Region: PRK12405
717608006789	FMN-binding domain; Region: FMN_bind; cl01081
717608006790	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
717608006791	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
717608006792	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
717608006793	SLBB domain; Region: SLBB; pfam10531
717608006794	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608006795	Cupin domain; Region: Cupin_2; pfam07883
717608006796	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717608006797	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
717608006798	putative active site [active]
717608006799	putative NTP binding site [chemical binding]; other site
717608006800	putative nucleic acid binding site [nucleotide binding]; other site
717608006801	CAT RNA binding domain; Region: CAT_RBD; smart01061
717608006802	transcriptional antiterminator BglG; Provisional; Region: PRK09772
717608006803	PRD domain; Region: PRD; pfam00874
717608006804	PRD domain; Region: PRD; pfam00874
717608006805	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
717608006806	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
717608006807	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
717608006808	active site turn [active]
717608006809	phosphorylation site [posttranslational modification]
717608006810	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
717608006811	HPr interaction site; other site
717608006812	glycerol kinase (GK) interaction site [polypeptide binding]; other site
717608006813	active site
717608006814	phosphorylation site [posttranslational modification]
717608006815	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
717608006816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608006817	dimer interface [polypeptide binding]; other site
717608006818	phosphorylation site [posttranslational modification]
717608006819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608006820	ATP binding site [chemical binding]; other site
717608006821	Mg2+ binding site [ion binding]; other site
717608006822	G-X-G motif; other site
717608006823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608006824	active site
717608006825	phosphorylation site [posttranslational modification]
717608006826	intermolecular recognition site; other site
717608006827	dimerization interface [polypeptide binding]; other site
717608006828	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
717608006829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608006830	active site
717608006831	phosphorylation site [posttranslational modification]
717608006832	intermolecular recognition site; other site
717608006833	dimerization interface [polypeptide binding]; other site
717608006834	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
717608006835	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717608006836	metal-binding site [ion binding]
717608006837	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608006838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608006839	active site
717608006840	motif I; other site
717608006841	motif II; other site
717608006842	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
717608006843	metal-binding site [ion binding]
717608006844	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
717608006845	putative active site [active]
717608006846	AAA-like domain; Region: AAA_10; pfam12846
717608006847	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
717608006848	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
717608006849	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
717608006850	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608006851	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
717608006852	Predicted transcriptional regulator [Transcription]; Region: COG3432
717608006853	MobA/MobL family; Region: MobA_MobL; pfam03389
717608006854	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
717608006855	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
717608006856	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
717608006857	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608006858	active site
717608006859	DNA binding site [nucleotide binding]
717608006860	Int/Topo IB signature motif; other site
717608006861	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
717608006862	HsdM N-terminal domain; Region: HsdM_N; pfam12161
717608006863	Methyltransferase domain; Region: Methyltransf_26; pfam13659
717608006864	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
717608006865	DEAD-like helicases superfamily; Region: DEXDc; smart00487
717608006866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608006867	ATP binding site [chemical binding]; other site
717608006868	putative Mg++ binding site [ion binding]; other site
717608006869	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
717608006870	Helix-turn-helix domain; Region: HTH_17; cl17695
717608006871	Fic family protein [Function unknown]; Region: COG3177
717608006872	Fic/DOC family; Region: Fic; pfam02661
717608006873	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608006874	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
717608006875	active site
717608006876	DNA binding site [nucleotide binding]
717608006877	Int/Topo IB signature motif; other site
717608006878	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
717608006879	Flavoprotein; Region: Flavoprotein; pfam02441
717608006880	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
717608006881	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
717608006882	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
717608006883	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608006884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
717608006885	alpha-galactosidase; Provisional; Region: PRK15076
717608006886	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
717608006887	NAD binding site [chemical binding]; other site
717608006888	sugar binding site [chemical binding]; other site
717608006889	divalent metal binding site [ion binding]; other site
717608006890	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
717608006891	dimer interface [polypeptide binding]; other site
717608006892	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
717608006893	active site
717608006894	metal binding site [ion binding]; metal-binding site
717608006895	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
717608006896	AAA domain; Region: AAA_23; pfam13476
717608006897	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
717608006898	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
717608006899	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
717608006900	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
717608006901	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608006902	Cupin domain; Region: Cupin_2; cl17218
717608006903	Helix-turn-helix domain; Region: HTH_18; pfam12833
717608006904	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
717608006905	Mrr N-terminal domain; Region: Mrr_N; pfam14338
717608006906	Restriction endonuclease; Region: Mrr_cat; pfam04471
717608006907	CHC2 zinc finger; Region: zf-CHC2; cl17510
717608006908	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
717608006909	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
717608006910	5S rRNA interface [nucleotide binding]; other site
717608006911	CTC domain interface [polypeptide binding]; other site
717608006912	L16 interface [polypeptide binding]; other site
717608006913	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
717608006914	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
717608006915	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
717608006916	MraW methylase family; Region: Methyltransf_5; cl17771
717608006917	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
717608006918	recombination factor protein RarA; Reviewed; Region: PRK13342
717608006919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608006920	Walker A motif; other site
717608006921	ATP binding site [chemical binding]; other site
717608006922	Walker B motif; other site
717608006923	arginine finger; other site
717608006924	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
717608006925	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
717608006926	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
717608006927	DNA binding residues [nucleotide binding]
717608006928	drug binding residues [chemical binding]; other site
717608006929	dimer interface [polypeptide binding]; other site
717608006930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608006931	dimer interface [polypeptide binding]; other site
717608006932	conserved gate region; other site
717608006933	ABC-ATPase subunit interface; other site
717608006934	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
717608006935	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
717608006936	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
717608006937	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
717608006938	Walker A/P-loop; other site
717608006939	ATP binding site [chemical binding]; other site
717608006940	Q-loop/lid; other site
717608006941	ABC transporter signature motif; other site
717608006942	Walker B; other site
717608006943	D-loop; other site
717608006944	H-loop/switch region; other site
717608006945	FOG: CBS domain [General function prediction only]; Region: COG0517
717608006946	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
717608006947	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
717608006948	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
717608006949	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717608006950	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608006951	active site
717608006952	catalytic tetrad [active]
717608006953	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608006954	Transglutaminase/protease-like homologues; Region: TGc; smart00460
717608006955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608006956	Coenzyme A binding pocket [chemical binding]; other site
717608006957	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608006958	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608006959	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
717608006960	active site
717608006961	catalytic triad [active]
717608006962	oxyanion hole [active]
717608006963	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
717608006964	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
717608006965	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
717608006966	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
717608006967	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
717608006968	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
717608006969	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
717608006970	putative acetyltransferase; Provisional; Region: PRK03624
717608006971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608006972	Coenzyme A binding pocket [chemical binding]; other site
717608006973	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608006974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608006975	active site
717608006976	phosphorylation site [posttranslational modification]
717608006977	intermolecular recognition site; other site
717608006978	dimerization interface [polypeptide binding]; other site
717608006979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608006980	DNA binding site [nucleotide binding]
717608006981	SLBB domain; Region: SLBB; pfam10531
717608006982	comEA protein; Region: comE; TIGR01259
717608006983	Helix-hairpin-helix motif; Region: HHH; pfam00633
717608006984	Protein of unknown function, DUF606; Region: DUF606; pfam04657
717608006985	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
717608006986	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
717608006987	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
717608006988	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
717608006989	homodimer interface [polypeptide binding]; other site
717608006990	NADP binding site [chemical binding]; other site
717608006991	substrate binding site [chemical binding]; other site
717608006992	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
717608006993	AzlC protein; Region: AzlC; cl00570
717608006994	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
717608006995	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
717608006996	TM-ABC transporter signature motif; other site
717608006997	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
717608006998	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
717608006999	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
717608007000	Walker A/P-loop; other site
717608007001	ATP binding site [chemical binding]; other site
717608007002	Q-loop/lid; other site
717608007003	ABC transporter signature motif; other site
717608007004	Walker B; other site
717608007005	D-loop; other site
717608007006	H-loop/switch region; other site
717608007007	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
717608007008	argininosuccinate synthase; Provisional; Region: PRK13820
717608007009	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
717608007010	ANP binding site [chemical binding]; other site
717608007011	Substrate Binding Site II [chemical binding]; other site
717608007012	Substrate Binding Site I [chemical binding]; other site
717608007013	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
717608007014	DHH family; Region: DHH; pfam01368
717608007015	DHHA1 domain; Region: DHHA1; pfam02272
717608007016	Protein of unknown function DUF45; Region: DUF45; pfam01863
717608007017	Transposase IS200 like; Region: Y1_Tnp; cl00848
717608007018	Transposase IS200 like; Region: Y1_Tnp; cl00848
717608007019	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
717608007020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
717608007021	non-specific DNA binding site [nucleotide binding]; other site
717608007022	salt bridge; other site
717608007023	sequence-specific DNA binding site [nucleotide binding]; other site
717608007024	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
717608007025	G1 box; other site
717608007026	GTP/Mg2+ binding site [chemical binding]; other site
717608007027	Switch I region; other site
717608007028	G2 box; other site
717608007029	G3 box; other site
717608007030	Switch II region; other site
717608007031	G4 box; other site
717608007032	G5 box; other site
717608007033	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
717608007034	dimer interface [polypeptide binding]; other site
717608007035	pyridoxal binding site [chemical binding]; other site
717608007036	ATP binding site [chemical binding]; other site
717608007037	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
717608007038	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
717608007039	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
717608007040	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
717608007041	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717608007042	substrate binding site [chemical binding]; other site
717608007043	ATP binding site [chemical binding]; other site
717608007044	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
717608007045	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
717608007046	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
717608007047	dimer interface [polypeptide binding]; other site
717608007048	active site
717608007049	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
717608007050	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
717608007051	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
717608007052	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
717608007053	Metal-binding active site; metal-binding site
717608007054	BtpA family; Region: BtpA; cl00440
717608007055	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
717608007056	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
717608007057	nucleotide binding site [chemical binding]; other site
717608007058	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
717608007059	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
717608007060	substrate binding site [chemical binding]; other site
717608007061	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
717608007062	ATP binding site [chemical binding]; other site
717608007063	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
717608007064	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
717608007065	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
717608007066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608007067	DNA-binding site [nucleotide binding]; DNA binding site
717608007068	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
717608007069	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
717608007070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608007071	dimer interface [polypeptide binding]; other site
717608007072	phosphorylation site [posttranslational modification]
717608007073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608007074	ATP binding site [chemical binding]; other site
717608007075	Mg2+ binding site [ion binding]; other site
717608007076	G-X-G motif; other site
717608007077	methionine aminopeptidase; Provisional; Region: PRK12318
717608007078	SEC-C motif; Region: SEC-C; pfam02810
717608007079	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
717608007080	active site
717608007081	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
717608007082	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
717608007083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
717608007084	Bacterial transcriptional activator domain; Region: BTAD; smart01043
717608007085	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
717608007086	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717608007087	metal ion-dependent adhesion site (MIDAS); other site
717608007088	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717608007089	metal ion-dependent adhesion site (MIDAS); other site
717608007090	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
717608007091	metal ion-dependent adhesion site (MIDAS); other site
717608007092	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717608007093	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717608007094	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717608007095	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
717608007096	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
717608007097	Catalytic site [active]
717608007098	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717608007099	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
717608007100	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
717608007101	Predicted permeases [General function prediction only]; Region: COG0679
717608007102	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
717608007103	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
717608007104	catalytic triad [active]
717608007105	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
717608007106	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
717608007107	AAA domain; Region: AAA_31; pfam13614
717608007108	Bacterial SH3 domain homologues; Region: SH3b; smart00287
717608007109	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
717608007110	active site
717608007111	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
717608007112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608007113	Coenzyme A binding pocket [chemical binding]; other site
717608007114	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
717608007115	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
717608007116	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
717608007117	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
717608007118	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
717608007119	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
717608007120	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
717608007121	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
717608007122	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
717608007123	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
717608007124	catalytic motif [active]
717608007125	Zn binding site [ion binding]; other site
717608007126	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
717608007127	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
717608007128	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
717608007129	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
717608007130	active site
717608007131	catalytic site [active]
717608007132	substrate binding site [chemical binding]; other site
717608007133	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717608007134	VanW like protein; Region: VanW; pfam04294
717608007135	G5 domain; Region: G5; pfam07501
717608007136	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
717608007137	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
717608007138	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
717608007139	AsnC family; Region: AsnC_trans_reg; pfam01037
717608007140	hypothetical protein; Validated; Region: PRK07682
717608007141	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608007142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608007143	homodimer interface [polypeptide binding]; other site
717608007144	catalytic residue [active]
717608007145	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
717608007146	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
717608007147	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
717608007148	active site
717608007149	dimer interface [polypeptide binding]; other site
717608007150	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
717608007151	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
717608007152	active site
717608007153	trimer interface [polypeptide binding]; other site
717608007154	allosteric site; other site
717608007155	active site lid [active]
717608007156	hexamer (dimer of trimers) interface [polypeptide binding]; other site
717608007157	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
717608007158	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
717608007159	putative active site cavity [active]
717608007160	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
717608007161	Class I aldolases; Region: Aldolase_Class_I; cl17187
717608007162	catalytic residue [active]
717608007163	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
717608007164	Na binding site [ion binding]; other site
717608007165	Domain of unknown function (DUF386); Region: DUF386; cl01047
717608007166	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
717608007167	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
717608007168	nucleotide binding site [chemical binding]; other site
717608007169	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
717608007170	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
717608007171	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
717608007172	putative active site [active]
717608007173	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
717608007174	4Fe-4S binding domain; Region: Fer4; pfam00037
717608007175	4Fe-4S binding domain; Region: Fer4; pfam00037
717608007176	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
717608007177	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
717608007178	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
717608007179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608007180	dimer interface [polypeptide binding]; other site
717608007181	conserved gate region; other site
717608007182	putative PBP binding loops; other site
717608007183	ABC-ATPase subunit interface; other site
717608007184	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
717608007185	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
717608007186	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
717608007187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608007188	putative PBP binding loops; other site
717608007189	dimer interface [polypeptide binding]; other site
717608007190	ABC-ATPase subunit interface; other site
717608007191	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
717608007192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608007193	Walker A/P-loop; other site
717608007194	ATP binding site [chemical binding]; other site
717608007195	Q-loop/lid; other site
717608007196	ABC transporter signature motif; other site
717608007197	Walker B; other site
717608007198	D-loop; other site
717608007199	H-loop/switch region; other site
717608007200	TOBE domain; Region: TOBE_2; pfam08402
717608007201	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
717608007202	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
717608007203	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
717608007204	Tetramer interface [polypeptide binding]; other site
717608007205	active site
717608007206	FMN-binding site [chemical binding]; other site
717608007207	hypothetical protein; Provisional; Region: PRK13690
717608007208	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
717608007209	TRAM domain; Region: TRAM; cl01282
717608007210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
717608007211	S-adenosylmethionine binding site [chemical binding]; other site
717608007212	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608007213	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608007214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717608007215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608007216	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
717608007217	metal binding site [ion binding]; metal-binding site
717608007218	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717608007219	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
717608007220	putative active site [active]
717608007221	putative NTP binding site [chemical binding]; other site
717608007222	putative nucleic acid binding site [nucleotide binding]; other site
717608007223	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
717608007224	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
717608007225	active site
717608007226	dimer interfaces [polypeptide binding]; other site
717608007227	catalytic residues [active]
717608007228	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
717608007229	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
717608007230	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
717608007231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608007232	dimer interface [polypeptide binding]; other site
717608007233	conserved gate region; other site
717608007234	putative PBP binding loops; other site
717608007235	ABC-ATPase subunit interface; other site
717608007236	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
717608007237	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608007238	Walker A/P-loop; other site
717608007239	ATP binding site [chemical binding]; other site
717608007240	Q-loop/lid; other site
717608007241	ABC transporter signature motif; other site
717608007242	Walker B; other site
717608007243	D-loop; other site
717608007244	H-loop/switch region; other site
717608007245	TOBE domain; Region: TOBE_2; pfam08402
717608007246	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
717608007247	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
717608007248	Metal-binding active site; metal-binding site
717608007249	AP (apurinic/apyrimidinic) site pocket; other site
717608007250	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
717608007251	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608007252	active site
717608007253	motif I; other site
717608007254	motif II; other site
717608007255	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608007256	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
717608007257	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
717608007258	DNA binding site [nucleotide binding]
717608007259	active site
717608007260	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
717608007261	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
717608007262	hexamer (dimer of trimers) interface [polypeptide binding]; other site
717608007263	substrate binding site [chemical binding]; other site
717608007264	trimer interface [polypeptide binding]; other site
717608007265	Mn binding site [ion binding]; other site
717608007266	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
717608007267	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608007268	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608007269	ABC transporter; Region: ABC_tran_2; pfam12848
717608007270	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608007271	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
717608007272	active site
717608007273	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
717608007274	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
717608007275	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
717608007276	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
717608007277	putative active site [active]
717608007278	putative NTP binding site [chemical binding]; other site
717608007279	putative nucleic acid binding site [nucleotide binding]; other site
717608007280	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
717608007281	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
717608007282	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
717608007283	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608007284	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
717608007285	active site
717608007286	putative catalytic site [active]
717608007287	DNA binding site [nucleotide binding]
717608007288	putative phosphate binding site [ion binding]; other site
717608007289	metal binding site A [ion binding]; metal-binding site
717608007290	AP binding site [nucleotide binding]; other site
717608007291	metal binding site B [ion binding]; metal-binding site
717608007292	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
717608007293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608007294	ABC transporter; Region: ABC_tran_2; pfam12848
717608007295	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
717608007296	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
717608007297	catalytic triad [active]
717608007298	putative active site [active]
717608007299	CAAX protease self-immunity; Region: Abi; pfam02517
717608007300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
717608007301	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
717608007302	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
717608007303	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
717608007304	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
717608007305	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
717608007306	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
717608007307	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
717608007308	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
717608007309	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
717608007310	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
717608007311	protein-rRNA interface [nucleotide binding]; other site
717608007312	putative translocon binding site; other site
717608007313	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
717608007314	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
717608007315	G-X-X-G motif; other site
717608007316	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
717608007317	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
717608007318	23S rRNA interface [nucleotide binding]; other site
717608007319	5S rRNA interface [nucleotide binding]; other site
717608007320	putative antibiotic binding site [chemical binding]; other site
717608007321	L25 interface [polypeptide binding]; other site
717608007322	L27 interface [polypeptide binding]; other site
717608007323	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
717608007324	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
717608007325	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
717608007326	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
717608007327	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
717608007328	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
717608007329	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
717608007330	5S rRNA interface [nucleotide binding]; other site
717608007331	L27 interface [polypeptide binding]; other site
717608007332	23S rRNA interface [nucleotide binding]; other site
717608007333	L5 interface [polypeptide binding]; other site
717608007334	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
717608007335	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
717608007336	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
717608007337	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
717608007338	23S rRNA binding site [nucleotide binding]; other site
717608007339	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
717608007340	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
717608007341	SecY translocase; Region: SecY; pfam00344
717608007342	adenylate kinase; Reviewed; Region: adk; PRK00279
717608007343	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
717608007344	AMP-binding site [chemical binding]; other site
717608007345	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
717608007346	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
717608007347	active site
717608007348	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
717608007349	RNA binding site [nucleotide binding]; other site
717608007350	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
717608007351	rRNA binding site [nucleotide binding]; other site
717608007352	predicted 30S ribosome binding site; other site
717608007353	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
717608007354	30S ribosomal protein S13; Region: bact_S13; TIGR03631
717608007355	30S ribosomal protein S11; Validated; Region: PRK05309
717608007356	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
717608007357	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
717608007358	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
717608007359	RNA binding surface [nucleotide binding]; other site
717608007360	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
717608007361	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
717608007362	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
717608007363	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
717608007364	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
717608007365	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717608007366	Walker A/P-loop; other site
717608007367	ATP binding site [chemical binding]; other site
717608007368	Q-loop/lid; other site
717608007369	ABC transporter signature motif; other site
717608007370	Walker B; other site
717608007371	D-loop; other site
717608007372	H-loop/switch region; other site
717608007373	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
717608007374	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
717608007375	Walker A/P-loop; other site
717608007376	ATP binding site [chemical binding]; other site
717608007377	Q-loop/lid; other site
717608007378	ABC transporter signature motif; other site
717608007379	Walker B; other site
717608007380	D-loop; other site
717608007381	H-loop/switch region; other site
717608007382	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
717608007383	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
717608007384	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
717608007385	dimerization interface 3.5A [polypeptide binding]; other site
717608007386	active site
717608007387	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608007388	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608007389	dimer interface [polypeptide binding]; other site
717608007390	phosphorylation site [posttranslational modification]
717608007391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608007392	ATP binding site [chemical binding]; other site
717608007393	Mg2+ binding site [ion binding]; other site
717608007394	G-X-G motif; other site
717608007395	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
717608007396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608007397	active site
717608007398	phosphorylation site [posttranslational modification]
717608007399	intermolecular recognition site; other site
717608007400	dimerization interface [polypeptide binding]; other site
717608007401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608007402	Walker A motif; other site
717608007403	ATP binding site [chemical binding]; other site
717608007404	Walker B motif; other site
717608007405	arginine finger; other site
717608007406	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
717608007407	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
717608007408	putative active site [active]
717608007409	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
717608007410	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
717608007411	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
717608007412	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
717608007413	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
717608007414	23S rRNA interface [nucleotide binding]; other site
717608007415	L3 interface [polypeptide binding]; other site
717608007416	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
717608007417	TIGR02646 family protein; Region: TIGR02646
717608007418	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
717608007419	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
717608007420	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
717608007421	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717608007422	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717608007423	substrate binding pocket [chemical binding]; other site
717608007424	membrane-bound complex binding site; other site
717608007425	hinge residues; other site
717608007426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608007427	dimer interface [polypeptide binding]; other site
717608007428	conserved gate region; other site
717608007429	putative PBP binding loops; other site
717608007430	ABC-ATPase subunit interface; other site
717608007431	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
717608007432	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
717608007433	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608007434	homodimer interface [polypeptide binding]; other site
717608007435	catalytic residue [active]
717608007436	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
717608007437	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608007438	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
717608007439	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
717608007440	putative active site [active]
717608007441	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
717608007442	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
717608007443	putative oligomer interface [polypeptide binding]; other site
717608007444	putative active site [active]
717608007445	metal binding site [ion binding]; metal-binding site
717608007446	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
717608007447	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
717608007448	Substrate binding site; other site
717608007449	Mg++ binding site; other site
717608007450	metal-binding site
717608007451	Mg++ binding site; other site
717608007452	metal-binding site
717608007453	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
717608007454	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
717608007455	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
717608007456	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
717608007457	dimer interface [polypeptide binding]; other site
717608007458	active site
717608007459	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
717608007460	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
717608007461	substrate binding site; other site
717608007462	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
717608007463	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
717608007464	NAD binding site [chemical binding]; other site
717608007465	homotetramer interface [polypeptide binding]; other site
717608007466	homodimer interface [polypeptide binding]; other site
717608007467	substrate binding site [chemical binding]; other site
717608007468	active site
717608007469	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
717608007470	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
717608007471	inhibitor-cofactor binding pocket; inhibition site
717608007472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
717608007473	catalytic residue [active]
717608007474	LicD family; Region: LicD; cl01378
717608007475	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
717608007476	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
717608007477	Ligand binding site; other site
717608007478	Putative Catalytic site; other site
717608007479	DXD motif; other site
717608007480	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
717608007481	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
717608007482	substrate binding pocket [chemical binding]; other site
717608007483	membrane-bound complex binding site; other site
717608007484	hinge residues; other site
717608007485	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
717608007486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608007487	dimer interface [polypeptide binding]; other site
717608007488	conserved gate region; other site
717608007489	putative PBP binding loops; other site
717608007490	ABC-ATPase subunit interface; other site
717608007491	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
717608007492	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
717608007493	Walker A/P-loop; other site
717608007494	ATP binding site [chemical binding]; other site
717608007495	Q-loop/lid; other site
717608007496	ABC transporter signature motif; other site
717608007497	Walker B; other site
717608007498	D-loop; other site
717608007499	H-loop/switch region; other site
717608007500	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
717608007501	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
717608007502	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
717608007503	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
717608007504	active site
717608007505	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
717608007506	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
717608007507	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
717608007508	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
717608007509	Transcriptional regulators [Transcription]; Region: GntR; COG1802
717608007510	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
717608007511	DNA-binding site [nucleotide binding]; DNA binding site
717608007512	FCD domain; Region: FCD; pfam07729
717608007513	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
717608007514	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
717608007515	active site
717608007516	catalytic tetrad [active]
717608007517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
717608007518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608007519	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
717608007520	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
717608007521	HlyD family secretion protein; Region: HlyD_3; pfam13437
717608007522	putative membrane fusion protein; Region: TIGR02828
717608007523	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
717608007524	Protein export membrane protein; Region: SecD_SecF; cl14618
717608007525	Outer membrane efflux protein; Region: OEP; pfam02321
717608007526	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
717608007527	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
717608007528	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
717608007529	ATP-grasp domain; Region: ATP-grasp_4; cl17255
717608007530	glutamate racemase; Provisional; Region: PRK00865
717608007531	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
717608007532	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
717608007533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
717608007534	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
717608007535	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
717608007536	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608007537	FeS/SAM binding site; other site
717608007538	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
717608007539	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608007540	FeS/SAM binding site; other site
717608007541	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
717608007542	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
717608007543	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
717608007544	G1 box; other site
717608007545	GTP/Mg2+ binding site [chemical binding]; other site
717608007546	Switch I region; other site
717608007547	G2 box; other site
717608007548	Switch II region; other site
717608007549	G3 box; other site
717608007550	G4 box; other site
717608007551	G5 box; other site
717608007552	Penicillinase repressor; Region: Pencillinase_R; cl17580
717608007553	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
717608007554	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
717608007555	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
717608007556	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
717608007557	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
717608007558	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
717608007559	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
717608007560	RPB1 interaction site [polypeptide binding]; other site
717608007561	RPB10 interaction site [polypeptide binding]; other site
717608007562	RPB11 interaction site [polypeptide binding]; other site
717608007563	RPB3 interaction site [polypeptide binding]; other site
717608007564	RPB12 interaction site [polypeptide binding]; other site
717608007565	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
717608007566	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
717608007567	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
717608007568	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
717608007569	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
717608007570	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
717608007571	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
717608007572	G-loop; other site
717608007573	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
717608007574	DNA binding site [nucleotide binding]
717608007575	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
717608007576	SnoaL-like domain; Region: SnoaL_3; pfam13474
717608007577	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
717608007578	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
717608007579	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
717608007580	metal binding site [ion binding]; metal-binding site
717608007581	active site
717608007582	I-site; other site
717608007583	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608007584	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
717608007585	active site
717608007586	metal binding site [ion binding]; metal-binding site
717608007587	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
717608007588	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
717608007589	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
717608007590	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
717608007591	active site
717608007592	substrate binding site [chemical binding]; other site
717608007593	metal binding site [ion binding]; metal-binding site
717608007594	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
717608007595	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
717608007596	rod shape-determining protein Mbl; Provisional; Region: PRK13928
717608007597	MreB and similar proteins; Region: MreB_like; cd10225
717608007598	nucleotide binding site [chemical binding]; other site
717608007599	Mg binding site [ion binding]; other site
717608007600	putative protofilament interaction site [polypeptide binding]; other site
717608007601	RodZ interaction site [polypeptide binding]; other site
717608007602	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
717608007603	AAA domain; Region: AAA_30; pfam13604
717608007604	Family description; Region: UvrD_C_2; pfam13538
717608007605	YcxB-like protein; Region: YcxB; pfam14317
717608007606	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
717608007607	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
717608007608	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
717608007609	putative homodimer interface [polypeptide binding]; other site
717608007610	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
717608007611	heterodimer interface [polypeptide binding]; other site
717608007612	homodimer interface [polypeptide binding]; other site
717608007613	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
717608007614	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
717608007615	23S rRNA interface [nucleotide binding]; other site
717608007616	L7/L12 interface [polypeptide binding]; other site
717608007617	putative thiostrepton binding site; other site
717608007618	L25 interface [polypeptide binding]; other site
717608007619	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
717608007620	mRNA/rRNA interface [nucleotide binding]; other site
717608007621	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
717608007622	23S rRNA interface [nucleotide binding]; other site
717608007623	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
717608007624	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
717608007625	core dimer interface [polypeptide binding]; other site
717608007626	peripheral dimer interface [polypeptide binding]; other site
717608007627	L10 interface [polypeptide binding]; other site
717608007628	L11 interface [polypeptide binding]; other site
717608007629	putative EF-Tu interaction site [polypeptide binding]; other site
717608007630	putative EF-G interaction site [polypeptide binding]; other site
717608007631	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
717608007632	ligand binding site [chemical binding]; other site
717608007633	active site
717608007634	UGI interface [polypeptide binding]; other site
717608007635	catalytic site [active]
717608007636	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
717608007637	recombination factor protein RarA; Reviewed; Region: PRK13342
717608007638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608007639	Walker A motif; other site
717608007640	ATP binding site [chemical binding]; other site
717608007641	Walker B motif; other site
717608007642	arginine finger; other site
717608007643	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
717608007644	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
717608007645	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
717608007646	Walker A/P-loop; other site
717608007647	ATP binding site [chemical binding]; other site
717608007648	Q-loop/lid; other site
717608007649	ABC transporter signature motif; other site
717608007650	Walker B; other site
717608007651	D-loop; other site
717608007652	H-loop/switch region; other site
717608007653	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
717608007654	putative carbohydrate binding site [chemical binding]; other site
717608007655	Methyltransferase domain; Region: Methyltransf_12; pfam08242
717608007656	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
717608007657	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
717608007658	Probable Catalytic site; other site
717608007659	metal-binding site
717608007660	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
717608007661	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
717608007662	TraX protein; Region: TraX; cl05434
717608007663	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
717608007664	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
717608007665	putative active site [active]
717608007666	PhoH-like protein; Region: PhoH; pfam02562
717608007667	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
717608007668	Zn2+ binding site [ion binding]; other site
717608007669	Mg2+ binding site [ion binding]; other site
717608007670	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
717608007671	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
717608007672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
717608007673	Coenzyme A binding pocket [chemical binding]; other site
717608007674	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
717608007675	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
717608007676	substrate binding site; other site
717608007677	tetramer interface; other site
717608007678	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
717608007679	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
717608007680	NAD binding site [chemical binding]; other site
717608007681	substrate binding site [chemical binding]; other site
717608007682	homodimer interface [polypeptide binding]; other site
717608007683	active site
717608007684	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
717608007685	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
717608007686	NADP binding site [chemical binding]; other site
717608007687	active site
717608007688	putative substrate binding site [chemical binding]; other site
717608007689	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
717608007690	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
717608007691	active site
717608007692	substrate binding site [chemical binding]; other site
717608007693	metal binding site [ion binding]; metal-binding site
717608007694	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
717608007695	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
717608007696	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
717608007697	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
717608007698	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
717608007699	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
717608007700	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
717608007701	active site
717608007702	FMN binding site [chemical binding]; other site
717608007703	substrate binding site [chemical binding]; other site
717608007704	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
717608007705	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
717608007706	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608007707	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
717608007708	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608007709	Walker A/P-loop; other site
717608007710	ATP binding site [chemical binding]; other site
717608007711	Q-loop/lid; other site
717608007712	ABC transporter signature motif; other site
717608007713	Walker B; other site
717608007714	D-loop; other site
717608007715	H-loop/switch region; other site
717608007716	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
717608007717	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
717608007718	dimerization interface [polypeptide binding]; other site
717608007719	putative DNA binding site [nucleotide binding]; other site
717608007720	putative Zn2+ binding site [ion binding]; other site
717608007721	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
717608007722	metal-binding site [ion binding]
717608007723	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
717608007724	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
717608007725	Soluble P-type ATPase [General function prediction only]; Region: COG4087
717608007726	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
717608007727	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
717608007728	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
717608007729	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
717608007730	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
717608007731	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
717608007732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
717608007733	substrate binding site [chemical binding]; other site
717608007734	oxyanion hole (OAH) forming residues; other site
717608007735	trimer interface [polypeptide binding]; other site
717608007736	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
717608007737	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
717608007738	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
717608007739	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
717608007740	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
717608007741	FAD binding site [chemical binding]; other site
717608007742	homotetramer interface [polypeptide binding]; other site
717608007743	substrate binding pocket [chemical binding]; other site
717608007744	catalytic base [active]
717608007745	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
717608007746	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
717608007747	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
717608007748	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
717608007749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
717608007750	NAD(P) binding site [chemical binding]; other site
717608007751	active site
717608007752	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
717608007753	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608007754	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717608007755	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608007756	Bacterial SH3 domain; Region: SH3_3; pfam08239
717608007757	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
717608007758	NlpC/P60 family; Region: NLPC_P60; pfam00877
717608007759	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
717608007760	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
717608007761	Formiminotransferase domain; Region: FTCD; pfam02971
717608007762	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
717608007763	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
717608007764	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
717608007765	Potassium binding sites [ion binding]; other site
717608007766	Cesium cation binding sites [ion binding]; other site
717608007767	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
717608007768	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
717608007769	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
717608007770	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
717608007771	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
717608007772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
717608007773	glycerol kinase; Provisional; Region: glpK; PRK00047
717608007774	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
717608007775	N- and C-terminal domain interface [polypeptide binding]; other site
717608007776	active site
717608007777	MgATP binding site [chemical binding]; other site
717608007778	catalytic site [active]
717608007779	metal binding site [ion binding]; metal-binding site
717608007780	glycerol binding site [chemical binding]; other site
717608007781	homotetramer interface [polypeptide binding]; other site
717608007782	homodimer interface [polypeptide binding]; other site
717608007783	FBP binding site [chemical binding]; other site
717608007784	protein IIAGlc interface [polypeptide binding]; other site
717608007785	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
717608007786	amphipathic channel; other site
717608007787	Asn-Pro-Ala signature motifs; other site
717608007788	Predicted dehydrogenase [General function prediction only]; Region: COG0579
717608007789	hydroxyglutarate oxidase; Provisional; Region: PRK11728
717608007790	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
717608007791	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
717608007792	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
717608007793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
717608007794	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
717608007795	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
717608007796	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
717608007797	HTH domain; Region: HTH_11; pfam08279
717608007798	PRD domain; Region: PRD; pfam00874
717608007799	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
717608007800	active site
717608007801	P-loop; other site
717608007802	phosphorylation site [posttranslational modification]
717608007803	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
717608007804	active site
717608007805	phosphorylation site [posttranslational modification]
717608007806	RDD family; Region: RDD; pfam06271
717608007807	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
717608007808	active site
717608007809	methionine cluster; other site
717608007810	phosphorylation site [posttranslational modification]
717608007811	metal binding site [ion binding]; metal-binding site
717608007812	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
717608007813	active site
717608007814	P-loop; other site
717608007815	phosphorylation site [posttranslational modification]
717608007816	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
717608007817	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
717608007818	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
717608007819	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
717608007820	active site
717608007821	dimer interface [polypeptide binding]; other site
717608007822	catalytic nucleophile [active]
717608007823	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
717608007824	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717608007825	metal binding site [ion binding]; metal-binding site
717608007826	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
717608007827	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
717608007828	Uncharacterized conserved protein [Function unknown]; Region: COG1284
717608007829	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717608007830	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
717608007831	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
717608007832	Uncharacterized conserved protein [Function unknown]; Region: COG3589
717608007833	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
717608007834	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
717608007835	30S subunit binding site; other site
717608007836	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
717608007837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
717608007838	ATP binding site [chemical binding]; other site
717608007839	putative Mg++ binding site [ion binding]; other site
717608007840	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
717608007841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
717608007842	nucleotide binding region [chemical binding]; other site
717608007843	ATP-binding site [chemical binding]; other site
717608007844	SEC-C motif; Region: SEC-C; pfam02810
717608007845	peptide chain release factor 2; Provisional; Region: PRK05589
717608007846	PCRF domain; Region: PCRF; pfam03462
717608007847	RF-1 domain; Region: RF-1; pfam00472
717608007848	hypothetical protein; Provisional; Region: PRK04435
717608007849	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
717608007850	DNA-binding interface [nucleotide binding]; DNA binding site
717608007851	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
717608007852	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
717608007853	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
717608007854	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
717608007855	aspartate kinase; Reviewed; Region: PRK06635
717608007856	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
717608007857	putative nucleotide binding site [chemical binding]; other site
717608007858	putative catalytic residues [active]
717608007859	putative Mg ion binding site [ion binding]; other site
717608007860	putative aspartate binding site [chemical binding]; other site
717608007861	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
717608007862	putative allosteric regulatory site; other site
717608007863	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
717608007864	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
717608007865	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
717608007866	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
717608007867	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
717608007868	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
717608007869	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
717608007870	RNA binding site [nucleotide binding]; other site
717608007871	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
717608007872	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
717608007873	BCCT family transporter; Region: BCCT; pfam02028
717608007874	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
717608007875	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
717608007876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608007877	Walker A motif; other site
717608007878	ATP binding site [chemical binding]; other site
717608007879	Walker B motif; other site
717608007880	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
717608007881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
717608007882	Integrase core domain; Region: rve; pfam00665
717608007883	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
717608007884	metal binding triad [ion binding]; metal-binding site
717608007885	AAA domain; Region: AAA_21; pfam13304
717608007886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
717608007887	ATP binding site [chemical binding]; other site
717608007888	putative Mg++ binding site [ion binding]; other site
717608007889	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
717608007890	VanZ like family; Region: VanZ; cl01971
717608007891	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
717608007892	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
717608007893	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
717608007894	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
717608007895	MgtE intracellular N domain; Region: MgtE_N; pfam03448
717608007896	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
717608007897	Divalent cation transporter; Region: MgtE; pfam01769
717608007898	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608007899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608007900	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608007901	dimerization interface [polypeptide binding]; other site
717608007902	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
717608007903	uracil transporter; Provisional; Region: PRK10720
717608007904	3D domain; Region: 3D; cl01439
717608007905	3D domain; Region: 3D; cl01439
717608007906	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
717608007907	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
717608007908	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
717608007909	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
717608007910	nucleotide binding site [chemical binding]; other site
717608007911	NEF interaction site [polypeptide binding]; other site
717608007912	SBD interface [polypeptide binding]; other site
717608007913	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
717608007914	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
717608007915	HSP70 interaction site [polypeptide binding]; other site
717608007916	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
717608007917	substrate binding site [polypeptide binding]; other site
717608007918	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
717608007919	Zn binding sites [ion binding]; other site
717608007920	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
717608007921	dimer interface [polypeptide binding]; other site
717608007922	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
717608007923	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
717608007924	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
717608007925	16S/18S rRNA binding site [nucleotide binding]; other site
717608007926	S13e-L30e interaction site [polypeptide binding]; other site
717608007927	25S rRNA binding site [nucleotide binding]; other site
717608007928	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
717608007929	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
717608007930	RNase E interface [polypeptide binding]; other site
717608007931	trimer interface [polypeptide binding]; other site
717608007932	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
717608007933	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
717608007934	RNase E interface [polypeptide binding]; other site
717608007935	trimer interface [polypeptide binding]; other site
717608007936	active site
717608007937	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
717608007938	putative nucleic acid binding region [nucleotide binding]; other site
717608007939	G-X-X-G motif; other site
717608007940	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
717608007941	RNA binding site [nucleotide binding]; other site
717608007942	domain interface; other site
717608007943	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608007944	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
717608007945	Walker A/P-loop; other site
717608007946	ATP binding site [chemical binding]; other site
717608007947	Q-loop/lid; other site
717608007948	ABC transporter signature motif; other site
717608007949	Walker B; other site
717608007950	D-loop; other site
717608007951	H-loop/switch region; other site
717608007952	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
717608007953	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
717608007954	MgtE intracellular N domain; Region: MgtE_N; smart00924
717608007955	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
717608007956	Divalent cation transporter; Region: MgtE; pfam01769
717608007957	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
717608007958	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608007959	active site
717608007960	HIGH motif; other site
717608007961	nucleotide binding site [chemical binding]; other site
717608007962	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
717608007963	active site
717608007964	KMSKS motif; other site
717608007965	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
717608007966	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
717608007967	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
717608007968	Na2 binding site [ion binding]; other site
717608007969	putative substrate binding site 1 [chemical binding]; other site
717608007970	Na binding site 1 [ion binding]; other site
717608007971	putative substrate binding site 2 [chemical binding]; other site
717608007972	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
717608007973	cell division protein MraZ; Reviewed; Region: PRK00326
717608007974	MraZ protein; Region: MraZ; pfam02381
717608007975	MraZ protein; Region: MraZ; pfam02381
717608007976	MraW methylase family; Region: Methyltransf_5; pfam01795
717608007977	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
717608007978	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
717608007979	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
717608007980	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
717608007981	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
717608007982	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
717608007983	Mg++ binding site [ion binding]; other site
717608007984	putative catalytic motif [active]
717608007985	putative substrate binding site [chemical binding]; other site
717608007986	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
717608007987	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
717608007988	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
717608007989	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
717608007990	sporulation sigma factor SigE; Reviewed; Region: PRK08301
717608007991	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608007992	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608007993	DNA binding residues [nucleotide binding]
717608007994	sporulation sigma factor SigG; Reviewed; Region: PRK08215
717608007995	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
717608007996	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
717608007997	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
717608007998	DNA binding residues [nucleotide binding]
717608007999	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
717608008000	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
717608008001	Yqey-like protein; Region: YqeY; cl17540
717608008002	dipeptidase PepV; Reviewed; Region: PRK07318
717608008003	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
717608008004	active site
717608008005	metal binding site [ion binding]; metal-binding site
717608008006	L-aspartate oxidase; Provisional; Region: PRK06175
717608008007	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
717608008008	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
717608008009	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
717608008010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
717608008011	active site
717608008012	motif I; other site
717608008013	motif II; other site
717608008014	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
717608008015	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
717608008016	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
717608008017	shikimate binding site; other site
717608008018	NAD(P) binding site [chemical binding]; other site
717608008019	shikimate kinase; Reviewed; Region: aroK; PRK00131
717608008020	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
717608008021	ADP binding site [chemical binding]; other site
717608008022	magnesium binding site [ion binding]; other site
717608008023	putative shikimate binding site; other site
717608008024	elongation factor P; Validated; Region: PRK00529
717608008025	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
717608008026	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
717608008027	RNA binding site [nucleotide binding]; other site
717608008028	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
717608008029	RNA binding site [nucleotide binding]; other site
717608008030	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
717608008031	Rubredoxin; Region: Rubredoxin; pfam00301
717608008032	iron binding site [ion binding]; other site
717608008033	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
717608008034	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
717608008035	active site
717608008036	catalytic site [active]
717608008037	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
717608008038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
717608008039	FeS/SAM binding site; other site
717608008040	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
717608008041	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
717608008042	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
717608008043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608008044	dimer interface [polypeptide binding]; other site
717608008045	conserved gate region; other site
717608008046	putative PBP binding loops; other site
717608008047	ABC-ATPase subunit interface; other site
717608008048	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
717608008049	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608008050	Walker A/P-loop; other site
717608008051	ATP binding site [chemical binding]; other site
717608008052	Q-loop/lid; other site
717608008053	ABC transporter signature motif; other site
717608008054	Walker B; other site
717608008055	D-loop; other site
717608008056	H-loop/switch region; other site
717608008057	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717608008058	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
717608008059	Walker A/P-loop; other site
717608008060	ATP binding site [chemical binding]; other site
717608008061	Q-loop/lid; other site
717608008062	ABC transporter signature motif; other site
717608008063	Walker B; other site
717608008064	D-loop; other site
717608008065	H-loop/switch region; other site
717608008066	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
717608008067	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
717608008068	classical (c) SDRs; Region: SDR_c; cd05233
717608008069	NAD(P) binding site [chemical binding]; other site
717608008070	active site
717608008071	NAD-dependent deacetylase; Provisional; Region: PRK00481
717608008072	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
717608008073	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
717608008074	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
717608008075	catalytic residues [active]
717608008076	4Fe-4S binding domain; Region: Fer4_5; pfam12801
717608008077	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
717608008078	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
717608008079	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
717608008080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
717608008081	Walker A/P-loop; other site
717608008082	ATP binding site [chemical binding]; other site
717608008083	Q-loop/lid; other site
717608008084	ABC transporter signature motif; other site
717608008085	Walker B; other site
717608008086	D-loop; other site
717608008087	H-loop/switch region; other site
717608008088	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
717608008089	TM-ABC transporter signature motif; other site
717608008090	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
717608008091	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
717608008092	zinc binding site [ion binding]; other site
717608008093	putative ligand binding site [chemical binding]; other site
717608008094	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
717608008095	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
717608008096	hinge; other site
717608008097	active site
717608008098	prephenate dehydrogenase; Validated; Region: PRK06545
717608008099	prephenate dehydrogenase; Validated; Region: PRK08507
717608008100	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
717608008101	elongation factor G; Reviewed; Region: PRK12740
717608008102	G1 box; other site
717608008103	putative GEF interaction site [polypeptide binding]; other site
717608008104	GTP/Mg2+ binding site [chemical binding]; other site
717608008105	Switch I region; other site
717608008106	G2 box; other site
717608008107	G3 box; other site
717608008108	Switch II region; other site
717608008109	G4 box; other site
717608008110	G5 box; other site
717608008111	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
717608008112	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
717608008113	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
717608008114	Tetratricopeptide repeat; Region: TPR_12; pfam13424
717608008115	Tetratricopeptide repeat; Region: TPR_12; pfam13424
717608008116	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
717608008117	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
717608008118	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
717608008119	HIGH motif; other site
717608008120	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
717608008121	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608008122	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
717608008123	active site
717608008124	KMSKS motif; other site
717608008125	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
717608008126	tRNA binding surface [nucleotide binding]; other site
717608008127	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
717608008128	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
717608008129	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
717608008130	active site
717608008131	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
717608008132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
717608008133	Walker A/P-loop; other site
717608008134	ATP binding site [chemical binding]; other site
717608008135	Q-loop/lid; other site
717608008136	ABC transporter signature motif; other site
717608008137	Walker B; other site
717608008138	D-loop; other site
717608008139	H-loop/switch region; other site
717608008140	NMT1/THI5 like; Region: NMT1; pfam09084
717608008141	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
717608008142	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
717608008143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
717608008144	dimer interface [polypeptide binding]; other site
717608008145	conserved gate region; other site
717608008146	putative PBP binding loops; other site
717608008147	ABC-ATPase subunit interface; other site
717608008148	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
717608008149	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018
717608008150	non-heme iron binding site [ion binding]; other site
717608008151	dimer interface [polypeptide binding]; other site
717608008152	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
717608008153	non-heme iron binding site [ion binding]; other site
717608008154	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
717608008155	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
717608008156	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
717608008157	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
717608008158	Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761
717608008159	putative active site [active]
717608008160	putative metal binding residues [ion binding]; other site
717608008161	signature motif; other site
717608008162	putative dimer interface [polypeptide binding]; other site
717608008163	putative phosphate binding site [ion binding]; other site
717608008164	Protein of unknown function (DUF975); Region: DUF975; cl10504
717608008165	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
717608008166	DJ-1 family protein; Region: not_thiJ; TIGR01383
717608008167	conserved cys residue [active]
717608008168	trigger factor; Provisional; Region: tig; PRK01490
717608008169	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
717608008170	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
717608008171	Clp protease; Region: CLP_protease; pfam00574
717608008172	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
717608008173	oligomer interface [polypeptide binding]; other site
717608008174	active site residues [active]
717608008175	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
717608008176	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
717608008177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
717608008178	Walker A motif; other site
717608008179	ATP binding site [chemical binding]; other site
717608008180	Walker B motif; other site
717608008181	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
717608008182	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
717608008183	Found in ATP-dependent protease La (LON); Region: LON; smart00464
717608008184	Tetratricopeptide repeat; Region: TPR_12; pfam13424
717608008185	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
717608008186	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
717608008187	HAMP domain; Region: HAMP; pfam00672
717608008188	dimerization interface [polypeptide binding]; other site
717608008189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
717608008190	dimer interface [polypeptide binding]; other site
717608008191	phosphorylation site [posttranslational modification]
717608008192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
717608008193	ATP binding site [chemical binding]; other site
717608008194	Mg2+ binding site [ion binding]; other site
717608008195	G-X-G motif; other site
717608008196	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
717608008197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
717608008198	active site
717608008199	phosphorylation site [posttranslational modification]
717608008200	intermolecular recognition site; other site
717608008201	dimerization interface [polypeptide binding]; other site
717608008202	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
717608008203	DNA binding site [nucleotide binding]
717608008204	DctM-like transporters; Region: DctM; pfam06808
717608008205	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
717608008206	Transcriptional regulator [Transcription]; Region: LysR; COG0583
717608008207	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
717608008208	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
717608008209	dimerization interface [polypeptide binding]; other site