-- dump date 20140619_044402 -- class Genbank::misc_feature -- table misc_feature_note -- id note 645463000001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463000002 ATP binding site [chemical binding]; other site 645463000003 Mg2+ binding site [ion binding]; other site 645463000004 G-X-G motif; other site 645463000005 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 645463000006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463000007 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463000008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 645463000009 DNA binding residues [nucleotide binding] 645463000010 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 645463000011 HTH domain; Region: HTH_11; pfam08279 645463000012 3H domain; Region: 3H; pfam02829 645463000013 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 645463000014 Conserved TM helix; Region: TM_helix; pfam05552 645463000015 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645463000016 seryl-tRNA synthetase; Provisional; Region: PRK05431 645463000017 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 645463000018 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 645463000019 dimer interface [polypeptide binding]; other site 645463000020 active site 645463000021 motif 1; other site 645463000022 motif 2; other site 645463000023 motif 3; other site 645463000024 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 645463000025 nucleoside/Zn binding site; other site 645463000026 dimer interface [polypeptide binding]; other site 645463000027 catalytic motif [active] 645463000028 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 645463000029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000030 Walker A motif; other site 645463000031 ATP binding site [chemical binding]; other site 645463000032 Walker B motif; other site 645463000033 arginine finger; other site 645463000034 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 645463000035 hypothetical protein; Validated; Region: PRK00153 645463000036 recombination protein RecR; Reviewed; Region: recR; PRK00076 645463000037 RecR protein; Region: RecR; pfam02132 645463000038 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 645463000039 putative active site [active] 645463000040 putative metal-binding site [ion binding]; other site 645463000041 tetramer interface [polypeptide binding]; other site 645463000042 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 645463000043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645463000044 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 645463000045 pyruvate carboxylase; Reviewed; Region: PRK12999 645463000046 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463000047 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645463000048 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645463000049 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 645463000050 active site 645463000051 catalytic residues [active] 645463000052 metal binding site [ion binding]; metal-binding site 645463000053 homodimer binding site [polypeptide binding]; other site 645463000054 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 645463000055 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645463000056 carboxyltransferase (CT) interaction site; other site 645463000057 biotinylation site [posttranslational modification]; other site 645463000058 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645463000059 elongation factor G; Reviewed; Region: PRK12740 645463000060 G1 box; other site 645463000061 GTP/Mg2+ binding site [chemical binding]; other site 645463000062 G2 box; other site 645463000063 Switch I region; other site 645463000064 G3 box; other site 645463000065 Switch II region; other site 645463000066 G4 box; other site 645463000067 G5 box; other site 645463000068 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 645463000069 Elongation Factor G, domain II; Region: EFG_II; pfam14492 645463000070 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 645463000071 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 645463000072 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 645463000073 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 645463000074 UvrB/uvrC motif; Region: UVR; pfam02151 645463000075 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 645463000076 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 645463000077 ADP binding site [chemical binding]; other site 645463000078 phosphagen binding site; other site 645463000079 substrate specificity loop; other site 645463000080 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 645463000081 Clp amino terminal domain; Region: Clp_N; pfam02861 645463000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000083 Walker A motif; other site 645463000084 ATP binding site [chemical binding]; other site 645463000085 Walker B motif; other site 645463000086 arginine finger; other site 645463000087 UvrB/uvrC motif; Region: UVR; pfam02151 645463000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000089 Walker A motif; other site 645463000090 ATP binding site [chemical binding]; other site 645463000091 Walker B motif; other site 645463000092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 645463000093 DNA repair protein RadA; Provisional; Region: PRK11823 645463000094 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 645463000095 Walker A motif/ATP binding site; other site 645463000096 ATP binding site [chemical binding]; other site 645463000097 Walker B motif; other site 645463000098 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 645463000099 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 645463000100 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 645463000101 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 645463000102 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 645463000103 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 645463000104 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 645463000105 putative active site [active] 645463000106 Cupin domain; Region: Cupin_2; cl17218 645463000107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463000108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463000109 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 645463000110 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 645463000111 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 645463000112 inhibitor binding site; inhibition site 645463000113 active site 645463000114 MFS/sugar transport protein; Region: MFS_2; pfam13347 645463000115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463000116 putative substrate translocation pore; other site 645463000117 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 645463000118 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645463000119 non-specific DNA interactions [nucleotide binding]; other site 645463000120 DNA binding site [nucleotide binding] 645463000121 sequence specific DNA binding site [nucleotide binding]; other site 645463000122 putative cAMP binding site [chemical binding]; other site 645463000123 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 645463000124 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 645463000125 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 645463000126 tetramer interface [polypeptide binding]; other site 645463000127 TPP-binding site [chemical binding]; other site 645463000128 heterodimer interface [polypeptide binding]; other site 645463000129 phosphorylation loop region [posttranslational modification] 645463000130 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 645463000131 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 645463000132 alpha subunit interface [polypeptide binding]; other site 645463000133 TPP binding site [chemical binding]; other site 645463000134 heterodimer interface [polypeptide binding]; other site 645463000135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463000136 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 645463000137 e3 binding domain; Region: E3_binding; pfam02817 645463000138 e3 binding domain; Region: E3_binding; pfam02817 645463000139 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 645463000140 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 645463000141 E3 interaction surface; other site 645463000142 lipoyl attachment site [posttranslational modification]; other site 645463000143 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 645463000144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463000145 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 645463000146 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 645463000147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000148 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463000149 Walker A motif; other site 645463000150 ATP binding site [chemical binding]; other site 645463000151 Walker B motif; other site 645463000152 arginine finger; other site 645463000153 PRD domain; Region: PRD; pfam00874 645463000154 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463000155 active pocket/dimerization site; other site 645463000156 active site 645463000157 phosphorylation site [posttranslational modification] 645463000158 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463000159 active site 645463000160 phosphorylation site [posttranslational modification] 645463000161 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463000162 active site 645463000163 phosphorylation site [posttranslational modification] 645463000164 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 645463000165 active site 645463000166 P-loop; other site 645463000167 phosphorylation site [posttranslational modification] 645463000168 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 645463000169 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 645463000170 intersubunit interface [polypeptide binding]; other site 645463000171 active site 645463000172 Zn2+ binding site [ion binding]; other site 645463000173 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645463000174 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 645463000175 substrate binding site; other site 645463000176 dimer interface; other site 645463000177 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 645463000178 homotrimer interaction site [polypeptide binding]; other site 645463000179 zinc binding site [ion binding]; other site 645463000180 CDP-binding sites; other site 645463000181 prolyl-tRNA synthetase; Provisional; Region: PRK09194 645463000182 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 645463000183 dimer interface [polypeptide binding]; other site 645463000184 motif 1; other site 645463000185 active site 645463000186 motif 2; other site 645463000187 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 645463000188 putative deacylase active site [active] 645463000189 motif 3; other site 645463000190 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 645463000191 anticodon binding site; other site 645463000192 prolyl-tRNA synthetase; Provisional; Region: PRK08661 645463000193 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 645463000194 dimer interface [polypeptide binding]; other site 645463000195 motif 1; other site 645463000196 active site 645463000197 motif 2; other site 645463000198 motif 3; other site 645463000199 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 645463000200 anticodon binding site; other site 645463000201 zinc-binding site [ion binding]; other site 645463000202 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 645463000203 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 645463000204 active site 645463000205 HIGH motif; other site 645463000206 KMSKS motif; other site 645463000207 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 645463000208 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 645463000209 active site 645463000210 HIGH motif; other site 645463000211 KMSKS motif; other site 645463000212 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 645463000213 tRNA binding surface [nucleotide binding]; other site 645463000214 anticodon binding site; other site 645463000215 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 645463000216 active site 645463000217 metal binding site [ion binding]; metal-binding site 645463000218 dimerization interface [polypeptide binding]; other site 645463000219 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 645463000220 dimerization interface [polypeptide binding]; other site 645463000221 active site 645463000222 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 645463000223 folate binding site [chemical binding]; other site 645463000224 NADP+ binding site [chemical binding]; other site 645463000225 SIR2-like domain; Region: SIR2_2; pfam13289 645463000226 ThiC family; Region: ThiC; cl08031 645463000227 Thymidylate synthase complementing protein; Region: Thy1; cl03630 645463000228 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 645463000229 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 645463000230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645463000231 YacP-like NYN domain; Region: NYN_YacP; pfam05991 645463000232 RNA polymerase factor sigma-70; Validated; Region: PRK08295 645463000233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463000234 elongation factor Tu; Reviewed; Region: PRK00049 645463000235 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 645463000236 G1 box; other site 645463000237 GEF interaction site [polypeptide binding]; other site 645463000238 GTP/Mg2+ binding site [chemical binding]; other site 645463000239 Switch I region; other site 645463000240 G2 box; other site 645463000241 G3 box; other site 645463000242 Switch II region; other site 645463000243 G4 box; other site 645463000244 G5 box; other site 645463000245 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 645463000246 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 645463000247 Antibiotic Binding Site [chemical binding]; other site 645463000248 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 645463000249 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 645463000250 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 645463000251 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 645463000252 putative homodimer interface [polypeptide binding]; other site 645463000253 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 645463000254 heterodimer interface [polypeptide binding]; other site 645463000255 homodimer interface [polypeptide binding]; other site 645463000256 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 645463000257 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 645463000258 23S rRNA interface [nucleotide binding]; other site 645463000259 L7/L12 interface [polypeptide binding]; other site 645463000260 putative thiostrepton binding site; other site 645463000261 L25 interface [polypeptide binding]; other site 645463000262 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 645463000263 mRNA/rRNA interface [nucleotide binding]; other site 645463000264 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 645463000265 23S rRNA interface [nucleotide binding]; other site 645463000266 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 645463000267 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 645463000268 core dimer interface [polypeptide binding]; other site 645463000269 peripheral dimer interface [polypeptide binding]; other site 645463000270 L10 interface [polypeptide binding]; other site 645463000271 L11 interface [polypeptide binding]; other site 645463000272 putative EF-Tu interaction site [polypeptide binding]; other site 645463000273 putative EF-G interaction site [polypeptide binding]; other site 645463000274 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 645463000275 classical (c) SDRs; Region: SDR_c; cd05233 645463000276 NAD(P) binding site [chemical binding]; other site 645463000277 active site 645463000278 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 645463000279 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 645463000280 RPB12 interaction site [polypeptide binding]; other site 645463000281 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 645463000282 RPB1 interaction site [polypeptide binding]; other site 645463000283 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 645463000284 RPB10 interaction site [polypeptide binding]; other site 645463000285 RPB11 interaction site [polypeptide binding]; other site 645463000286 RPB3 interaction site [polypeptide binding]; other site 645463000287 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 645463000288 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 645463000289 beta and beta' interface [polypeptide binding]; other site 645463000290 beta' and sigma factor interface [polypeptide binding]; other site 645463000291 Zn-binding [ion binding]; other site 645463000292 active site region [active] 645463000293 catalytic site [active] 645463000294 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 645463000295 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 645463000296 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 645463000297 G-loop; other site 645463000298 DNA binding site [nucleotide binding] 645463000299 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 645463000300 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 645463000301 S17 interaction site [polypeptide binding]; other site 645463000302 S8 interaction site; other site 645463000303 16S rRNA interaction site [nucleotide binding]; other site 645463000304 streptomycin interaction site [chemical binding]; other site 645463000305 23S rRNA interaction site [nucleotide binding]; other site 645463000306 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 645463000307 30S ribosomal protein S7; Validated; Region: PRK05302 645463000308 elongation factor G; Reviewed; Region: PRK00007 645463000309 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 645463000310 G1 box; other site 645463000311 putative GEF interaction site [polypeptide binding]; other site 645463000312 GTP/Mg2+ binding site [chemical binding]; other site 645463000313 Switch I region; other site 645463000314 G2 box; other site 645463000315 G3 box; other site 645463000316 Switch II region; other site 645463000317 G4 box; other site 645463000318 G5 box; other site 645463000319 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 645463000320 Elongation Factor G, domain II; Region: EFG_II; pfam14492 645463000321 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 645463000322 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 645463000323 elongation factor Tu; Reviewed; Region: PRK00049 645463000324 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 645463000325 G1 box; other site 645463000326 GEF interaction site [polypeptide binding]; other site 645463000327 GTP/Mg2+ binding site [chemical binding]; other site 645463000328 Switch I region; other site 645463000329 G2 box; other site 645463000330 G3 box; other site 645463000331 Switch II region; other site 645463000332 G4 box; other site 645463000333 G5 box; other site 645463000334 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 645463000335 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 645463000336 Antibiotic Binding Site [chemical binding]; other site 645463000337 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 645463000338 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 645463000339 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 645463000340 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 645463000341 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 645463000342 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 645463000343 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 645463000344 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 645463000345 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 645463000346 putative translocon binding site; other site 645463000347 protein-rRNA interface [nucleotide binding]; other site 645463000348 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 645463000349 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 645463000350 G-X-X-G motif; other site 645463000351 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 645463000352 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 645463000353 23S rRNA interface [nucleotide binding]; other site 645463000354 5S rRNA interface [nucleotide binding]; other site 645463000355 putative antibiotic binding site [chemical binding]; other site 645463000356 L25 interface [polypeptide binding]; other site 645463000357 L27 interface [polypeptide binding]; other site 645463000358 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 645463000359 23S rRNA interface [nucleotide binding]; other site 645463000360 putative translocon interaction site; other site 645463000361 signal recognition particle (SRP54) interaction site; other site 645463000362 L23 interface [polypeptide binding]; other site 645463000363 trigger factor interaction site; other site 645463000364 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 645463000365 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 645463000366 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 645463000367 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 645463000368 RNA binding site [nucleotide binding]; other site 645463000369 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 645463000370 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 645463000371 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 645463000372 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 645463000373 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 645463000374 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 645463000375 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645463000376 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 645463000377 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 645463000378 5S rRNA interface [nucleotide binding]; other site 645463000379 L27 interface [polypeptide binding]; other site 645463000380 23S rRNA interface [nucleotide binding]; other site 645463000381 L5 interface [polypeptide binding]; other site 645463000382 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 645463000383 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 645463000384 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 645463000385 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 645463000386 23S rRNA binding site [nucleotide binding]; other site 645463000387 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 645463000388 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 645463000389 SecY translocase; Region: SecY; pfam00344 645463000390 adenylate kinase; Reviewed; Region: adk; PRK00279 645463000391 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 645463000392 AMP-binding site [chemical binding]; other site 645463000393 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 645463000394 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645463000395 active site 645463000396 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 645463000397 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 645463000398 rRNA binding site [nucleotide binding]; other site 645463000399 predicted 30S ribosome binding site; other site 645463000400 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 645463000401 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 645463000402 30S ribosomal protein S11; Validated; Region: PRK05309 645463000403 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 645463000404 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 645463000405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463000406 RNA binding surface [nucleotide binding]; other site 645463000407 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 645463000408 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 645463000409 alphaNTD - beta interaction site [polypeptide binding]; other site 645463000410 alphaNTD homodimer interface [polypeptide binding]; other site 645463000411 alphaNTD - beta' interaction site [polypeptide binding]; other site 645463000412 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 645463000413 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 645463000414 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 645463000415 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645463000416 Walker A/P-loop; other site 645463000417 ATP binding site [chemical binding]; other site 645463000418 Q-loop/lid; other site 645463000419 ABC transporter signature motif; other site 645463000420 Walker B; other site 645463000421 D-loop; other site 645463000422 H-loop/switch region; other site 645463000423 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 645463000424 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645463000425 Walker A/P-loop; other site 645463000426 ATP binding site [chemical binding]; other site 645463000427 Q-loop/lid; other site 645463000428 ABC transporter signature motif; other site 645463000429 Walker B; other site 645463000430 D-loop; other site 645463000431 H-loop/switch region; other site 645463000432 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 645463000433 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 645463000434 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 645463000435 dimerization interface 3.5A [polypeptide binding]; other site 645463000436 active site 645463000437 internal frameshift and truncated protein; similar to 50S ribosomal protein L13 (pseudogene) 645463000438 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 645463000439 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463000440 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463000441 active site 645463000442 metal binding site [ion binding]; metal-binding site 645463000443 aspartate aminotransferase; Provisional; Region: PRK05764 645463000444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463000445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463000446 homodimer interface [polypeptide binding]; other site 645463000447 catalytic residue [active] 645463000448 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 645463000449 ATP cone domain; Region: ATP-cone; pfam03477 645463000450 Class III ribonucleotide reductase; Region: RNR_III; cd01675 645463000451 effector binding site; other site 645463000452 active site 645463000453 Zn binding site [ion binding]; other site 645463000454 glycine loop; other site 645463000455 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 645463000456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463000457 FeS/SAM binding site; other site 645463000458 similar to 16S ribosomal RNA 645463000459 Uncharacterized conserved protein [Function unknown]; Region: COG1624 645463000460 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 645463000461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 645463000462 YbbR-like protein; Region: YbbR; pfam07949 645463000463 phosphate butyryltransferase; Validated; Region: PRK05805 645463000464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463000465 nucleotide binding site [chemical binding]; other site 645463000466 Acetokinase family; Region: Acetate_kinase; cl17229 645463000467 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463000468 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463000469 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 645463000470 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 645463000471 dimer interface [polypeptide binding]; other site 645463000472 PYR/PP interface [polypeptide binding]; other site 645463000473 TPP binding site [chemical binding]; other site 645463000474 substrate binding site [chemical binding]; other site 645463000475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463000476 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 645463000477 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 645463000478 TPP-binding site [chemical binding]; other site 645463000479 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 645463000480 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 645463000481 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 645463000482 active site 645463000483 substrate binding site [chemical binding]; other site 645463000484 metal binding site [ion binding]; metal-binding site 645463000485 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 645463000486 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 645463000487 glutaminase active site [active] 645463000488 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 645463000489 dimer interface [polypeptide binding]; other site 645463000490 active site 645463000491 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 645463000492 dimer interface [polypeptide binding]; other site 645463000493 active site 645463000494 Rhodanese-like domain; Region: Rhodanese; pfam00581 645463000495 active site residue [active] 645463000496 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 645463000497 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 645463000498 active site residue [active] 645463000499 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 645463000500 active site residue [active] 645463000501 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 645463000502 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 645463000503 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 645463000504 hinge; other site 645463000505 active site 645463000506 Stage II sporulation protein; Region: SpoIID; pfam08486 645463000507 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 645463000508 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 645463000509 Peptidase family M23; Region: Peptidase_M23; pfam01551 645463000510 Stage III sporulation protein D; Region: SpoIIID; pfam12116 645463000511 rod shape-determining protein Mbl; Provisional; Region: PRK13928 645463000512 MreB and similar proteins; Region: MreB_like; cd10225 645463000513 nucleotide binding site [chemical binding]; other site 645463000514 Mg binding site [ion binding]; other site 645463000515 putative protofilament interaction site [polypeptide binding]; other site 645463000516 RodZ interaction site [polypeptide binding]; other site 645463000517 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 645463000518 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 645463000519 S-adenosylmethionine synthetase; Validated; Region: PRK05250 645463000520 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 645463000521 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 645463000522 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 645463000523 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463000524 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 645463000525 AAA domain; Region: AAA_30; pfam13604 645463000526 Family description; Region: UvrD_C_2; pfam13538 645463000527 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 645463000528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463000529 active site 645463000530 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463000531 PRD domain; Region: PRD; pfam00874 645463000532 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463000533 active site 645463000534 P-loop; other site 645463000535 phosphorylation site [posttranslational modification] 645463000536 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463000537 active site 645463000538 phosphorylation site [posttranslational modification] 645463000539 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 645463000540 methionine cluster; other site 645463000541 active site 645463000542 phosphorylation site [posttranslational modification] 645463000543 metal binding site [ion binding]; metal-binding site 645463000544 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463000545 active site 645463000546 P-loop; other site 645463000547 phosphorylation site [posttranslational modification] 645463000548 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463000549 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 645463000550 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 645463000551 active site 645463000552 dimer interface [polypeptide binding]; other site 645463000553 catalytic nucleophile [active] 645463000554 dipeptidase PepV; Reviewed; Region: PRK07318 645463000555 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645463000556 active site 645463000557 metal binding site [ion binding]; metal-binding site 645463000558 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 645463000559 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 645463000560 30S subunit binding site; other site 645463000561 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 645463000562 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463000563 ATP binding site [chemical binding]; other site 645463000564 putative Mg++ binding site [ion binding]; other site 645463000565 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 645463000566 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 645463000567 SEC-C motif; Region: SEC-C; pfam02810 645463000568 peptide chain release factor 2; Validated; Region: prfB; PRK00578 645463000569 PCRF domain; Region: PCRF; pfam03462 645463000570 RF-1 domain; Region: RF-1; pfam00472 645463000571 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 645463000572 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 645463000573 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 645463000574 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 645463000575 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 645463000576 RNA binding site [nucleotide binding]; other site 645463000577 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 645463000578 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 645463000579 active site 645463000580 Predicted membrane protein [Function unknown]; Region: COG3601 645463000581 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463000582 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463000583 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463000584 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463000585 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 645463000586 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 645463000587 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 645463000588 Glycoprotease family; Region: Peptidase_M22; pfam00814 645463000589 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 645463000590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463000591 Coenzyme A binding pocket [chemical binding]; other site 645463000592 UGMP family protein; Validated; Region: PRK09604 645463000593 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463000594 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 645463000595 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 645463000596 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 645463000597 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 645463000598 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 645463000599 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463000600 CAAX protease self-immunity; Region: Abi; pfam02517 645463000601 CAAX protease self-immunity; Region: Abi; pfam02517 645463000602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 645463000603 active site 645463000604 metal binding site [ion binding]; metal-binding site 645463000605 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 645463000606 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463000607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463000608 active site 645463000609 phosphorylation site [posttranslational modification] 645463000610 intermolecular recognition site; other site 645463000611 dimerization interface [polypeptide binding]; other site 645463000612 LytTr DNA-binding domain; Region: LytTR; smart00850 645463000613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463000614 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 645463000615 Walker A/P-loop; other site 645463000616 ATP binding site [chemical binding]; other site 645463000617 Q-loop/lid; other site 645463000618 ABC transporter signature motif; other site 645463000619 Walker B; other site 645463000620 D-loop; other site 645463000621 H-loop/switch region; other site 645463000622 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 645463000623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463000624 FeS/SAM binding site; other site 645463000625 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 645463000626 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 645463000627 amino acid transporter; Region: 2A0306; TIGR00909 645463000628 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463000629 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463000630 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463000631 metal binding site [ion binding]; metal-binding site 645463000632 dimer interface [polypeptide binding]; other site 645463000633 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 645463000634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000635 Walker A motif; other site 645463000636 ATP binding site [chemical binding]; other site 645463000637 Walker B motif; other site 645463000638 arginine finger; other site 645463000639 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645463000640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645463000641 ligand binding site [chemical binding]; other site 645463000642 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463000643 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 645463000644 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645463000645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463000646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463000647 ABC transporter; Region: ABC_tran_2; pfam12848 645463000648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463000649 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 645463000650 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 645463000651 CoA binding domain; Region: CoA_binding; pfam02629 645463000652 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 645463000653 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 645463000654 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 645463000655 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463000656 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463000657 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 645463000658 putative active site [active] 645463000659 putative metal binding site [ion binding]; other site 645463000660 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463000661 ACS interaction site; other site 645463000662 CODH interaction site; other site 645463000663 metal cluster binding site [ion binding]; other site 645463000664 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 645463000665 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463000666 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 645463000667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463000668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463000669 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 645463000670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463000671 S-adenosylmethionine binding site [chemical binding]; other site 645463000672 AAA domain; Region: AAA_17; cl19128 645463000673 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 645463000674 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 645463000675 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 645463000676 NAD(P) binding site [chemical binding]; other site 645463000677 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463000678 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463000679 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 645463000680 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463000681 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645463000682 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463000683 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 645463000684 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645463000685 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645463000686 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 645463000687 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 645463000688 FAD binding pocket [chemical binding]; other site 645463000689 FAD binding motif [chemical binding]; other site 645463000690 phosphate binding motif [ion binding]; other site 645463000691 beta-alpha-beta structure motif; other site 645463000692 NAD binding pocket [chemical binding]; other site 645463000693 Iron coordination center [ion binding]; other site 645463000694 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 645463000695 heterodimer interface [polypeptide binding]; other site 645463000696 active site 645463000697 FMN binding site [chemical binding]; other site 645463000698 homodimer interface [polypeptide binding]; other site 645463000699 substrate binding site [chemical binding]; other site 645463000700 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463000701 active site 645463000702 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 645463000703 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 645463000704 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 645463000705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463000706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463000707 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 645463000708 putative dimerization interface [polypeptide binding]; other site 645463000709 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 645463000710 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 645463000711 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 645463000712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645463000713 minor groove reading motif; other site 645463000714 helix-hairpin-helix signature motif; other site 645463000715 substrate binding pocket [chemical binding]; other site 645463000716 active site 645463000717 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 645463000718 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 645463000719 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 645463000720 putative active site [active] 645463000721 catalytic site [active] 645463000722 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 645463000723 putative active site [active] 645463000724 catalytic site [active] 645463000725 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 645463000726 oligomerisation interface [polypeptide binding]; other site 645463000727 mobile loop; other site 645463000728 roof hairpin; other site 645463000729 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 645463000730 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 645463000731 ring oligomerisation interface [polypeptide binding]; other site 645463000732 ATP/Mg binding site [chemical binding]; other site 645463000733 stacking interactions; other site 645463000734 hinge regions; other site 645463000735 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 645463000736 AIR carboxylase; Region: AIRC; smart01001 645463000737 GMP synthase; Reviewed; Region: guaA; PRK00074 645463000738 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 645463000739 AMP/PPi binding site [chemical binding]; other site 645463000740 candidate oxyanion hole; other site 645463000741 catalytic triad [active] 645463000742 potential glutamine specificity residues [chemical binding]; other site 645463000743 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 645463000744 ATP Binding subdomain [chemical binding]; other site 645463000745 Ligand Binding sites [chemical binding]; other site 645463000746 Dimerization subdomain; other site 645463000747 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 645463000748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 645463000749 active site 645463000750 metal binding site [ion binding]; metal-binding site 645463000751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463000752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463000753 LysR substrate binding domain; Region: LysR_substrate; pfam03466 645463000754 dimerization interface [polypeptide binding]; other site 645463000755 Chromate transporter; Region: Chromate_transp; pfam02417 645463000756 Chromate transporter; Region: Chromate_transp; cl17781 645463000757 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 645463000758 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 645463000759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463000760 Walker A/P-loop; other site 645463000761 ATP binding site [chemical binding]; other site 645463000762 Q-loop/lid; other site 645463000763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463000764 ABC transporter signature motif; other site 645463000765 Walker B; other site 645463000766 D-loop; other site 645463000767 H-loop/switch region; other site 645463000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463000769 Walker A/P-loop; other site 645463000770 ATP binding site [chemical binding]; other site 645463000771 Q-loop/lid; other site 645463000772 ABC transporter signature motif; other site 645463000773 Walker B; other site 645463000774 D-loop; other site 645463000775 H-loop/switch region; other site 645463000776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463000777 metal binding site [ion binding]; metal-binding site 645463000778 active site 645463000779 I-site; other site 645463000780 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463000781 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463000782 PRD domain; Region: PRD; pfam00874 645463000783 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463000784 active site 645463000785 P-loop; other site 645463000786 phosphorylation site [posttranslational modification] 645463000787 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463000788 active site 645463000789 phosphorylation site [posttranslational modification] 645463000790 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463000791 active site 645463000792 phosphorylation site [posttranslational modification] 645463000793 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 645463000794 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463000795 active site 645463000796 P-loop; other site 645463000797 phosphorylation site [posttranslational modification] 645463000798 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 645463000799 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 645463000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463000801 motif II; other site 645463000802 Coat F domain; Region: Coat_F; pfam07875 645463000803 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 645463000804 putative FMN binding site [chemical binding]; other site 645463000805 AIR carboxylase; Region: AIRC; pfam00731 645463000806 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 645463000807 ATP binding site [chemical binding]; other site 645463000808 active site 645463000809 substrate binding site [chemical binding]; other site 645463000810 amidophosphoribosyltransferase; Region: purF; TIGR01134 645463000811 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 645463000812 active site 645463000813 tetramer interface [polypeptide binding]; other site 645463000814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463000815 active site 645463000816 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 645463000817 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 645463000818 dimerization interface [polypeptide binding]; other site 645463000819 putative ATP binding site [chemical binding]; other site 645463000820 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 645463000821 active site 645463000822 substrate binding site [chemical binding]; other site 645463000823 cosubstrate binding site; other site 645463000824 catalytic site [active] 645463000825 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 645463000826 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 645463000827 purine monophosphate binding site [chemical binding]; other site 645463000828 dimer interface [polypeptide binding]; other site 645463000829 putative catalytic residues [active] 645463000830 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 645463000831 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 645463000832 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 645463000833 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 645463000834 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 645463000835 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 645463000836 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 645463000837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463000838 dimerization interface [polypeptide binding]; other site 645463000839 ATP binding site [chemical binding]; other site 645463000840 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 645463000841 dimerization interface [polypeptide binding]; other site 645463000842 ATP binding site [chemical binding]; other site 645463000843 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 645463000844 conserved cys residue [active] 645463000845 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 645463000846 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 645463000847 NADP binding site [chemical binding]; other site 645463000848 active site 645463000849 putative substrate binding site [chemical binding]; other site 645463000850 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 645463000851 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 645463000852 substrate binding site; other site 645463000853 tetramer interface; other site 645463000854 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 645463000855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 645463000856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 645463000857 NAD binding site [chemical binding]; other site 645463000858 substrate binding site [chemical binding]; other site 645463000859 homodimer interface [polypeptide binding]; other site 645463000860 active site 645463000861 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645463000862 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645463000863 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645463000864 catalytic residue [active] 645463000865 Protein of unknown function (DUF327); Region: DUF327; pfam03885 645463000866 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 645463000867 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 645463000868 FlgN protein; Region: FlgN; pfam05130 645463000869 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 645463000870 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645463000871 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 645463000872 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645463000873 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 645463000874 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 645463000875 FliW protein; Region: FliW; pfam02623 645463000876 Global regulator protein family; Region: CsrA; pfam02599 645463000877 Flagellar protein FliS; Region: FliS; cl00654 645463000878 Flagellar protein FliS; Region: FliS; cl00654 645463000879 flagellar capping protein; Validated; Region: fliD; PRK07737 645463000880 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 645463000881 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 645463000882 Flagellar protein FliT; Region: FliT; pfam05400 645463000883 flagellin; Reviewed; Region: PRK08869 645463000884 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 645463000885 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 645463000886 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463000887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 645463000888 active site 645463000889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463000890 binding surface 645463000891 TPR motif; other site 645463000892 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463000893 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 645463000894 Probable Catalytic site; other site 645463000895 metal-binding site 645463000896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463000897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463000898 S-adenosylmethionine binding site [chemical binding]; other site 645463000899 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 645463000900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 645463000901 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 645463000902 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 645463000903 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 645463000904 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 645463000905 inhibitor-cofactor binding pocket; inhibition site 645463000906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463000907 catalytic residue [active] 645463000908 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 645463000909 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 645463000910 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 645463000911 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645463000912 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645463000913 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 645463000914 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 645463000915 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 645463000916 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 645463000917 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 645463000918 FliG N-terminal domain; Region: FliG_N; pfam14842 645463000919 FliG middle domain; Region: FliG_M; pfam14841 645463000920 FliG C-terminal domain; Region: FliG_C; pfam01706 645463000921 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 645463000922 Protein of unknown function (DUF2799); Region: DUF2799; cl19633 645463000923 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 645463000924 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645463000925 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 645463000926 Walker A motif/ATP binding site; other site 645463000927 Walker B motif; other site 645463000928 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 645463000929 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 645463000930 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 645463000931 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 645463000932 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 645463000933 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645463000934 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645463000935 Flagellar protein (FlbD); Region: FlbD; pfam06289 645463000936 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 645463000937 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 645463000938 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 645463000939 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 645463000940 ligand binding site [chemical binding]; other site 645463000941 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 645463000942 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 645463000943 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 645463000944 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 645463000945 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 645463000946 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 645463000947 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 645463000948 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 645463000949 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 645463000950 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 645463000951 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 645463000952 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 645463000953 P-loop; other site 645463000954 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 645463000955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463000956 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463000957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463000958 DNA binding residues [nucleotide binding] 645463000959 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 645463000960 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645463000961 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 645463000962 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 645463000963 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 645463000964 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 645463000965 Flagellar motor switch protein FliM; Region: FliM; pfam02154 645463000966 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 645463000967 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 645463000968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463000969 binding surface 645463000970 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645463000971 TPR motif; other site 645463000972 heat shock protein 90; Provisional; Region: PRK05218 645463000973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463000974 ATP binding site [chemical binding]; other site 645463000975 Mg2+ binding site [ion binding]; other site 645463000976 G-X-G motif; other site 645463000977 Hsp90 protein; Region: HSP90; pfam00183 645463000978 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 645463000979 putative active site [active] 645463000980 metal binding site [ion binding]; metal-binding site 645463000981 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 645463000982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463000983 FeS/SAM binding site; other site 645463000984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463000985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463000986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463000987 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463000988 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 645463000989 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463000990 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 645463000991 putative hydrolase; Validated; Region: PRK09248 645463000992 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 645463000993 active site 645463000994 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 645463000995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463000996 Walker A motif; other site 645463000997 ATP binding site [chemical binding]; other site 645463000998 Walker B motif; other site 645463000999 arginine finger; other site 645463001000 Transcriptional antiterminator [Transcription]; Region: COG3933 645463001001 PRD domain; Region: PRD; pfam00874 645463001002 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463001003 active pocket/dimerization site; other site 645463001004 active site 645463001005 phosphorylation site [posttranslational modification] 645463001006 PRD domain; Region: PRD; pfam00874 645463001007 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645463001008 active pocket/dimerization site; other site 645463001009 active site 645463001010 phosphorylation site [posttranslational modification] 645463001011 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 645463001012 active site 645463001013 phosphorylation site [posttranslational modification] 645463001014 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463001015 active pocket/dimerization site; other site 645463001016 active site 645463001017 phosphorylation site [posttranslational modification] 645463001018 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 645463001019 active site 645463001020 phosphorylation site [posttranslational modification] 645463001021 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 645463001022 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 645463001023 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 645463001024 dipeptidase PepV; Reviewed; Region: PRK07318 645463001025 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645463001026 active site 645463001027 metal binding site [ion binding]; metal-binding site 645463001028 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463001029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463001030 non-specific DNA binding site [nucleotide binding]; other site 645463001031 salt bridge; other site 645463001032 sequence-specific DNA binding site [nucleotide binding]; other site 645463001033 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463001034 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463001035 Walker A/P-loop; other site 645463001036 ATP binding site [chemical binding]; other site 645463001037 Q-loop/lid; other site 645463001038 ABC transporter signature motif; other site 645463001039 Walker B; other site 645463001040 D-loop; other site 645463001041 H-loop/switch region; other site 645463001042 Acyltransferase family; Region: Acyl_transf_3; cl19154 645463001043 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 645463001044 Domain of unknown function (DUF362); Region: DUF362; cl19822 645463001045 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 645463001046 biotin synthase; Region: bioB; TIGR00433 645463001047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463001048 FeS/SAM binding site; other site 645463001049 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 645463001050 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463001051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463001052 DNA binding site [nucleotide binding] 645463001053 domain linker motif; other site 645463001054 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 645463001055 dimerization interface [polypeptide binding]; other site 645463001056 ligand binding site [chemical binding]; other site 645463001057 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 645463001058 substrate binding site [chemical binding]; other site 645463001059 dimer interface [polypeptide binding]; other site 645463001060 ATP binding site [chemical binding]; other site 645463001061 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 645463001062 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 645463001063 ligand binding site [chemical binding]; other site 645463001064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 645463001065 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 645463001066 Walker A/P-loop; other site 645463001067 ATP binding site [chemical binding]; other site 645463001068 Q-loop/lid; other site 645463001069 ABC transporter signature motif; other site 645463001070 Walker B; other site 645463001071 D-loop; other site 645463001072 H-loop/switch region; other site 645463001073 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 645463001074 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 645463001075 TM-ABC transporter signature motif; other site 645463001076 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 645463001077 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 645463001078 metal binding site [ion binding]; metal-binding site 645463001079 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 645463001080 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 645463001081 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 645463001082 putative metal binding site [ion binding]; other site 645463001083 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 645463001084 FMN binding site [chemical binding]; other site 645463001085 dimer interface [polypeptide binding]; other site 645463001086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463001087 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 645463001088 Tetratricopeptide repeat; Region: TPR_16; pfam13432 645463001089 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463001090 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 645463001091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463001092 dimerization interface [polypeptide binding]; other site 645463001093 putative DNA binding site [nucleotide binding]; other site 645463001094 putative Zn2+ binding site [ion binding]; other site 645463001095 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645463001096 metal-binding site [ion binding] 645463001097 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645463001098 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645463001099 metal-binding site [ion binding] 645463001100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463001101 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463001102 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 645463001103 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 645463001104 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463001105 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463001106 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463001107 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463001108 Walker A/P-loop; other site 645463001109 ATP binding site [chemical binding]; other site 645463001110 Q-loop/lid; other site 645463001111 ABC transporter signature motif; other site 645463001112 Walker B; other site 645463001113 D-loop; other site 645463001114 H-loop/switch region; other site 645463001115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001117 dimer interface [polypeptide binding]; other site 645463001118 phosphorylation site [posttranslational modification] 645463001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001120 ATP binding site [chemical binding]; other site 645463001121 Mg2+ binding site [ion binding]; other site 645463001122 G-X-G motif; other site 645463001123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001125 active site 645463001126 phosphorylation site [posttranslational modification] 645463001127 intermolecular recognition site; other site 645463001128 dimerization interface [polypeptide binding]; other site 645463001129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001130 DNA binding site [nucleotide binding] 645463001131 Helix-turn-helix domain; Region: HTH_17; pfam12728 645463001132 MoxR-like ATPases [General function prediction only]; Region: COG0714 645463001133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 645463001134 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 645463001135 metal ion-dependent adhesion site (MIDAS); other site 645463001136 cobalt transport protein CbiM; Validated; Region: PRK08319 645463001137 cobalt transport protein CbiN; Provisional; Region: PRK02898 645463001138 Cobalt transport protein; Region: CbiQ; cl00463 645463001139 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 645463001140 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 645463001141 Walker A/P-loop; other site 645463001142 ATP binding site [chemical binding]; other site 645463001143 Q-loop/lid; other site 645463001144 ABC transporter signature motif; other site 645463001145 Walker B; other site 645463001146 D-loop; other site 645463001147 H-loop/switch region; other site 645463001148 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 645463001149 Part of AAA domain; Region: AAA_19; pfam13245 645463001150 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 645463001151 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 645463001152 active site 645463001153 metal binding site [ion binding]; metal-binding site 645463001154 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 645463001155 active site 645463001156 nucleophile elbow; other site 645463001157 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 645463001158 active site 645463001159 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 645463001160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 645463001161 DRTGG domain; Region: DRTGG; pfam07085 645463001162 CBS domain; Region: CBS; pfam00571 645463001163 DHHA2 domain; Region: DHHA2; pfam02833 645463001164 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 645463001165 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 645463001166 putative catalytic cysteine [active] 645463001167 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 645463001168 putative active site [active] 645463001169 metal binding site [ion binding]; metal-binding site 645463001170 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463001171 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463001172 Walker A/P-loop; other site 645463001173 ATP binding site [chemical binding]; other site 645463001174 Q-loop/lid; other site 645463001175 ABC transporter signature motif; other site 645463001176 Walker B; other site 645463001177 D-loop; other site 645463001178 H-loop/switch region; other site 645463001179 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463001180 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463001181 FtsX-like permease family; Region: FtsX; pfam02687 645463001182 FtsX-like permease family; Region: FtsX; pfam02687 645463001183 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 645463001184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001185 ATP binding site [chemical binding]; other site 645463001186 Mg2+ binding site [ion binding]; other site 645463001187 G-X-G motif; other site 645463001188 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463001189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001190 active site 645463001191 phosphorylation site [posttranslational modification] 645463001192 intermolecular recognition site; other site 645463001193 dimerization interface [polypeptide binding]; other site 645463001194 LytTr DNA-binding domain; Region: LytTR; pfam04397 645463001195 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 645463001196 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 645463001197 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 645463001198 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645463001199 synthetase active site [active] 645463001200 NTP binding site [chemical binding]; other site 645463001201 metal binding site [ion binding]; metal-binding site 645463001202 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 645463001203 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 645463001204 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 645463001205 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463001206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463001207 S-adenosylmethionine binding site [chemical binding]; other site 645463001208 Uncharacterized conserved protein [Function unknown]; Region: COG5663 645463001209 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463001210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463001211 non-specific DNA binding site [nucleotide binding]; other site 645463001212 salt bridge; other site 645463001213 sequence-specific DNA binding site [nucleotide binding]; other site 645463001214 Cupin domain; Region: Cupin_2; pfam07883 645463001215 D-aminoacyl-tRNA deacylase; Region: tRNA_deacylase; cl00716 645463001216 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645463001217 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463001218 active site turn [active] 645463001219 phosphorylation site [posttranslational modification] 645463001220 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463001221 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463001222 HPr interaction site; other site 645463001223 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463001224 active site 645463001225 phosphorylation site [posttranslational modification] 645463001226 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 645463001227 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463001228 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463001229 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463001230 PRD domain; Region: PRD; pfam00874 645463001231 PRD domain; Region: PRD; pfam00874 645463001232 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 645463001233 active site 645463001234 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 645463001235 Ligand Binding Site [chemical binding]; other site 645463001236 Molecular Tunnel; other site 645463001237 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 645463001238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463001239 FeS/SAM binding site; other site 645463001240 TIGR04002 family protein; Region: TIGR04002 645463001241 D-lactate dehydrogenase; Validated; Region: PRK08605 645463001242 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 645463001243 homodimer interface [polypeptide binding]; other site 645463001244 ligand binding site [chemical binding]; other site 645463001245 NAD binding site [chemical binding]; other site 645463001246 catalytic site [active] 645463001247 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 645463001248 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463001249 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 645463001250 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 645463001251 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 645463001252 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 645463001253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645463001254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645463001255 active site 645463001256 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645463001257 Ligand binding site [chemical binding]; other site 645463001258 Electron transfer flavoprotein domain; Region: ETF; pfam01012 645463001259 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645463001260 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 645463001261 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645463001262 PAS domain; Region: PAS; smart00091 645463001263 PAS domain; Region: PAS_9; pfam13426 645463001264 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 645463001265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463001266 Walker A motif; other site 645463001267 ATP binding site [chemical binding]; other site 645463001268 Walker B motif; other site 645463001269 arginine finger; other site 645463001270 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 645463001271 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645463001272 intersubunit interface [polypeptide binding]; other site 645463001273 active site 645463001274 zinc binding site [ion binding]; other site 645463001275 Na+ binding site [ion binding]; other site 645463001276 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 645463001277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 645463001278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463001279 RNA binding surface [nucleotide binding]; other site 645463001280 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 645463001281 active site 645463001282 uracil binding [chemical binding]; other site 645463001283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463001284 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463001285 Probable transposase; Region: OrfB_IS605; pfam01385 645463001286 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463001287 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 645463001288 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 645463001289 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001290 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001291 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001292 putative transposase OrfB; Reviewed; Region: PHA02517 645463001293 HTH-like domain; Region: HTH_21; pfam13276 645463001294 Integrase core domain; Region: rve; pfam00665 645463001295 Integrase core domain; Region: rve_2; pfam13333 645463001296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463001297 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463001298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463001299 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463001300 PAS domain; Region: PAS_9; pfam13426 645463001301 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 645463001302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463001303 Walker A motif; other site 645463001304 ATP binding site [chemical binding]; other site 645463001305 Walker B motif; other site 645463001306 arginine finger; other site 645463001307 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463001308 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 645463001309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 645463001310 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 645463001311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463001312 catalytic residue [active] 645463001313 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 645463001314 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 645463001315 B12 binding site [chemical binding]; other site 645463001316 MutL protein; Region: MutL; pfam13941 645463001317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 645463001318 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 645463001319 dimer interface [polypeptide binding]; other site 645463001320 active site 645463001321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463001322 substrate binding site [chemical binding]; other site 645463001323 catalytic residue [active] 645463001324 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 645463001325 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463001326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 645463001327 active site 645463001328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463001329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463001330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645463001331 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 645463001332 Part of AAA domain; Region: AAA_19; pfam13245 645463001333 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 645463001334 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 645463001335 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645463001336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463001337 Walker A/P-loop; other site 645463001338 ATP binding site [chemical binding]; other site 645463001339 Q-loop/lid; other site 645463001340 ABC transporter signature motif; other site 645463001341 Walker B; other site 645463001342 D-loop; other site 645463001343 H-loop/switch region; other site 645463001344 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 645463001345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463001346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463001347 Walker A/P-loop; other site 645463001348 ATP binding site [chemical binding]; other site 645463001349 Q-loop/lid; other site 645463001350 ABC transporter signature motif; other site 645463001351 Walker B; other site 645463001352 D-loop; other site 645463001353 H-loop/switch region; other site 645463001354 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463001355 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463001356 FtsX-like permease family; Region: FtsX; pfam02687 645463001357 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463001358 FtsX-like permease family; Region: FtsX; pfam02687 645463001359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001361 dimer interface [polypeptide binding]; other site 645463001362 phosphorylation site [posttranslational modification] 645463001363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001364 ATP binding site [chemical binding]; other site 645463001365 Mg2+ binding site [ion binding]; other site 645463001366 G-X-G motif; other site 645463001367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001369 active site 645463001370 dimerization interface [polypeptide binding]; other site 645463001371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001372 DNA binding site [nucleotide binding] 645463001373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463001374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463001375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463001376 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463001377 Probable transposase; Region: OrfB_IS605; pfam01385 645463001378 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463001379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463001380 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463001381 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463001382 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463001383 putative active site [active] 645463001384 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463001385 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463001386 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463001387 putative active site [active] 645463001388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463001389 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645463001390 active site 645463001391 motif I; other site 645463001392 motif II; other site 645463001393 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463001394 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 645463001395 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 645463001396 Ca binding site [ion binding]; other site 645463001397 active site 645463001398 catalytic site [active] 645463001399 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 645463001400 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463001401 active site turn [active] 645463001402 phosphorylation site [posttranslational modification] 645463001403 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463001404 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463001405 HPr interaction site; other site 645463001406 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463001407 active site 645463001408 phosphorylation site [posttranslational modification] 645463001409 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463001410 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 645463001411 Penicillinase repressor; Region: Penicillinase_R; pfam03965 645463001412 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463001413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463001414 MarR family; Region: MarR_2; pfam12802 645463001415 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 645463001416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463001417 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 645463001418 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 645463001419 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 645463001420 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463001421 Walker A/P-loop; other site 645463001422 ATP binding site [chemical binding]; other site 645463001423 Q-loop/lid; other site 645463001424 ABC transporter signature motif; other site 645463001425 Walker B; other site 645463001426 D-loop; other site 645463001427 H-loop/switch region; other site 645463001428 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 645463001429 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 645463001430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001432 active site 645463001433 phosphorylation site [posttranslational modification] 645463001434 intermolecular recognition site; other site 645463001435 dimerization interface [polypeptide binding]; other site 645463001436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001437 DNA binding site [nucleotide binding] 645463001438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463001440 dimerization interface [polypeptide binding]; other site 645463001441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001442 dimer interface [polypeptide binding]; other site 645463001443 phosphorylation site [posttranslational modification] 645463001444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001445 ATP binding site [chemical binding]; other site 645463001446 Mg2+ binding site [ion binding]; other site 645463001447 G-X-G motif; other site 645463001448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463001449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463001450 FtsX-like permease family; Region: FtsX; pfam02687 645463001451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463001452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463001453 FtsX-like permease family; Region: FtsX; pfam02687 645463001454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463001455 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463001456 Walker A/P-loop; other site 645463001457 ATP binding site [chemical binding]; other site 645463001458 Q-loop/lid; other site 645463001459 ABC transporter signature motif; other site 645463001460 Walker B; other site 645463001461 D-loop; other site 645463001462 H-loop/switch region; other site 645463001463 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 645463001464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463001466 dimerization interface [polypeptide binding]; other site 645463001467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001468 dimer interface [polypeptide binding]; other site 645463001469 phosphorylation site [posttranslational modification] 645463001470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001471 ATP binding site [chemical binding]; other site 645463001472 Mg2+ binding site [ion binding]; other site 645463001473 G-X-G motif; other site 645463001474 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001476 active site 645463001477 phosphorylation site [posttranslational modification] 645463001478 intermolecular recognition site; other site 645463001479 dimerization interface [polypeptide binding]; other site 645463001480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001481 DNA binding site [nucleotide binding] 645463001482 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 645463001483 putative active site [active] 645463001484 catalytic triad [active] 645463001485 dimer interface [polypeptide binding]; other site 645463001486 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 645463001487 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 645463001488 ATP binding site [chemical binding]; other site 645463001489 active site 645463001490 substrate binding site [chemical binding]; other site 645463001491 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645463001492 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 645463001493 putative NAD(P) binding site [chemical binding]; other site 645463001494 catalytic Zn binding site [ion binding]; other site 645463001495 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645463001496 active pocket/dimerization site; other site 645463001497 active site 645463001498 phosphorylation site [posttranslational modification] 645463001499 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 645463001500 active site 645463001501 phosphorylation site [posttranslational modification] 645463001502 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 645463001503 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 645463001504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001506 active site 645463001507 phosphorylation site [posttranslational modification] 645463001508 intermolecular recognition site; other site 645463001509 dimerization interface [polypeptide binding]; other site 645463001510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001511 DNA binding site [nucleotide binding] 645463001512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463001514 dimerization interface [polypeptide binding]; other site 645463001515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001516 dimer interface [polypeptide binding]; other site 645463001517 phosphorylation site [posttranslational modification] 645463001518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001519 ATP binding site [chemical binding]; other site 645463001520 Mg2+ binding site [ion binding]; other site 645463001521 G-X-G motif; other site 645463001522 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001523 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001524 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463001525 flagellin; Validated; Region: PRK08026 645463001526 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645463001527 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 645463001528 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 645463001529 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 645463001530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463001531 Walker A motif; other site 645463001532 ATP binding site [chemical binding]; other site 645463001533 Walker B motif; other site 645463001534 arginine finger; other site 645463001535 Transcriptional antiterminator [Transcription]; Region: COG3933 645463001536 PRD domain; Region: PRD; pfam00874 645463001537 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645463001538 active pocket/dimerization site; other site 645463001539 active site 645463001540 phosphorylation site [posttranslational modification] 645463001541 PRD domain; Region: PRD; pfam00874 645463001542 Uncharacterized conserved protein [Function unknown]; Region: COG2966 645463001543 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 645463001544 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 645463001545 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 645463001546 GAF domain; Region: GAF_3; pfam13492 645463001547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001548 dimer interface [polypeptide binding]; other site 645463001549 phosphorylation site [posttranslational modification] 645463001550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001551 ATP binding site [chemical binding]; other site 645463001552 Mg2+ binding site [ion binding]; other site 645463001553 G-X-G motif; other site 645463001554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001556 active site 645463001557 phosphorylation site [posttranslational modification] 645463001558 intermolecular recognition site; other site 645463001559 dimerization interface [polypeptide binding]; other site 645463001560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001561 DNA binding site [nucleotide binding] 645463001562 GAF domain; Region: GAF_2; pfam13185 645463001563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463001564 metal binding site [ion binding]; metal-binding site 645463001565 active site 645463001566 I-site; other site 645463001567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463001568 metal binding site [ion binding]; metal-binding site 645463001569 active site 645463001570 I-site; other site 645463001571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463001572 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645463001573 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 645463001574 peptidase T-like protein; Region: PepT-like; TIGR01883 645463001575 metal binding site [ion binding]; metal-binding site 645463001576 putative dimer interface [polypeptide binding]; other site 645463001577 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 645463001578 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 645463001579 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463001580 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 645463001581 metal binding site [ion binding]; metal-binding site 645463001582 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 645463001583 Predicted transcriptional regulator [Transcription]; Region: COG2378 645463001584 HTH domain; Region: HTH_11; pfam08279 645463001585 WYL domain; Region: WYL; pfam13280 645463001586 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463001587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001588 active site 645463001589 phosphorylation site [posttranslational modification] 645463001590 intermolecular recognition site; other site 645463001591 dimerization interface [polypeptide binding]; other site 645463001592 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 645463001593 CheC-like family; Region: CheC; pfam04509 645463001594 CheD chemotactic sensory transduction; Region: CheD; cl00810 645463001595 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 645463001596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001597 active site 645463001598 phosphorylation site [posttranslational modification] 645463001599 intermolecular recognition site; other site 645463001600 dimerization interface [polypeptide binding]; other site 645463001601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463001602 metal binding site [ion binding]; metal-binding site 645463001603 active site 645463001604 I-site; other site 645463001605 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 645463001606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463001607 dimerization interface [polypeptide binding]; other site 645463001608 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 645463001609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 645463001610 dimer interface [polypeptide binding]; other site 645463001611 putative CheW interface [polypeptide binding]; other site 645463001612 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 645463001613 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 645463001614 putative binding surface; other site 645463001615 active site 645463001616 P2 response regulator binding domain; Region: P2; pfam07194 645463001617 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 645463001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001619 ATP binding site [chemical binding]; other site 645463001620 Mg2+ binding site [ion binding]; other site 645463001621 G-X-G motif; other site 645463001622 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 645463001623 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 645463001624 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 645463001625 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 645463001626 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 645463001627 CheB methylesterase; Region: CheB_methylest; pfam01339 645463001628 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645463001629 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645463001630 ornithine cyclodeaminase; Validated; Region: PRK08618 645463001631 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 645463001632 Protein of unknown function (DUF975); Region: DUF975; cl10504 645463001633 Penicillinase repressor; Region: Penicillinase_R; pfam03965 645463001634 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463001635 Formin Homology 2 Domain; Region: FH2; cl19758 645463001636 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645463001637 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645463001638 Protease prsW family; Region: PrsW-protease; pfam13367 645463001639 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 645463001640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463001641 S-adenosylmethionine binding site [chemical binding]; other site 645463001642 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 645463001643 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645463001644 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645463001645 Catalytic site [active] 645463001646 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 645463001647 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645463001648 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645463001649 Catalytic site [active] 645463001650 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645463001651 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 645463001652 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 645463001653 active site 645463001654 glutaminase A; Region: Gln_ase; TIGR03814 645463001655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463001656 dimerization interface [polypeptide binding]; other site 645463001657 putative DNA binding site [nucleotide binding]; other site 645463001658 putative Zn2+ binding site [ion binding]; other site 645463001659 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 645463001660 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 645463001661 AP (apurinic/apyrimidinic) site pocket; other site 645463001662 DNA interaction; other site 645463001663 Metal-binding active site; metal-binding site 645463001664 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 645463001665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645463001666 active site 645463001667 catalytic tetrad [active] 645463001668 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 645463001669 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 645463001670 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 645463001671 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 645463001672 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463001673 AAA domain; Region: AAA_32; pfam13654 645463001674 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 645463001675 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645463001676 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 645463001677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 645463001678 minor groove reading motif; other site 645463001679 helix-hairpin-helix signature motif; other site 645463001680 substrate binding pocket [chemical binding]; other site 645463001681 active site 645463001682 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 645463001683 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 645463001684 EDD domain protein, DegV family; Region: DegV; TIGR00762 645463001685 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 645463001686 ligand binding site [chemical binding]; other site 645463001687 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 645463001688 ligand binding site [chemical binding]; other site 645463001689 YtxC-like family; Region: YtxC; cl08500 645463001690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 645463001691 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 645463001692 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 645463001693 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645463001694 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 645463001695 active site 645463001696 dimer interface [polypeptide binding]; other site 645463001697 motif 1; other site 645463001698 motif 2; other site 645463001699 motif 3; other site 645463001700 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 645463001701 anticodon binding site; other site 645463001702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463001703 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463001704 Probable transposase; Region: OrfB_IS605; pfam01385 645463001705 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463001706 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 645463001707 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 645463001708 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 645463001709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001711 ATP binding site [chemical binding]; other site 645463001712 Mg2+ binding site [ion binding]; other site 645463001713 G-X-G motif; other site 645463001714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 645463001715 H+ Antiporter protein; Region: 2A0121; TIGR00900 645463001716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463001717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463001718 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 645463001719 tetrameric interface [polypeptide binding]; other site 645463001720 activator binding site; other site 645463001721 NADP binding site [chemical binding]; other site 645463001722 substrate binding site [chemical binding]; other site 645463001723 catalytic residues [active] 645463001724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463001725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463001726 phosphoenolpyruvate synthase; Validated; Region: PRK06241 645463001727 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 645463001728 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645463001729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463001730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463001731 Walker A/P-loop; other site 645463001732 ATP binding site [chemical binding]; other site 645463001733 transposase-like protein b pseudogene 645463001734 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 645463001735 G1 box; other site 645463001736 GTP/Mg2+ binding site [chemical binding]; other site 645463001737 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 645463001738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645463001739 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463001740 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645463001741 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 645463001742 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 645463001743 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 645463001744 Active Sites [active] 645463001745 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 645463001746 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 645463001747 ParB-like nuclease domain; Region: ParBc; pfam02195 645463001748 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 645463001749 CotJB protein; Region: CotJB; pfam12652 645463001750 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 645463001751 dimanganese center [ion binding]; other site 645463001752 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 645463001753 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 645463001754 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 645463001755 DNA binding site [nucleotide binding] 645463001756 active site 645463001757 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 645463001758 GrpB protein; Region: GrpB; pfam04229 645463001759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463001760 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463001761 Probable transposase; Region: OrfB_IS605; pfam01385 645463001762 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463001763 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463001764 GrpB protein; Region: GrpB; pfam04229 645463001765 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 645463001766 GHKL domain; Region: HATPase_c_5; pfam14501 645463001767 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463001768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001769 active site 645463001770 phosphorylation site [posttranslational modification] 645463001771 intermolecular recognition site; other site 645463001772 dimerization interface [polypeptide binding]; other site 645463001773 LytTr DNA-binding domain; Region: LytTR; smart00850 645463001774 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463001775 FtsX-like permease family; Region: FtsX; pfam02687 645463001776 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463001777 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463001778 Walker A/P-loop; other site 645463001779 ATP binding site [chemical binding]; other site 645463001780 Q-loop/lid; other site 645463001781 ABC transporter signature motif; other site 645463001782 Walker B; other site 645463001783 D-loop; other site 645463001784 H-loop/switch region; other site 645463001785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463001786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463001787 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463001788 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645463001789 DNA binding residues [nucleotide binding] 645463001790 drug binding residues [chemical binding]; other site 645463001791 dimer interface [polypeptide binding]; other site 645463001792 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463001793 CAAX amino terminal protease family; Region: Abi; cl00558 645463001794 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463001795 LytTr DNA-binding domain; Region: LytTR; smart00850 645463001796 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 645463001797 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 645463001798 Mor transcription activator family; Region: Mor; cl02360 645463001799 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 645463001800 non-specific DNA interactions [nucleotide binding]; other site 645463001801 DNA binding site [nucleotide binding] 645463001802 sequence specific DNA binding site [nucleotide binding]; other site 645463001803 putative cAMP binding site [chemical binding]; other site 645463001804 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 645463001805 replicative DNA helicase; Region: DnaB; TIGR00665 645463001806 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 645463001807 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 645463001808 Walker A motif; other site 645463001809 ATP binding site [chemical binding]; other site 645463001810 Walker B motif; other site 645463001811 Mor transcription activator family; Region: Mor; cl02360 645463001812 Ferredoxin [Energy production and conversion]; Region: COG1146 645463001813 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463001814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463001815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463001816 Walker A/P-loop; other site 645463001817 ATP binding site [chemical binding]; other site 645463001818 Q-loop/lid; other site 645463001819 ABC transporter signature motif; other site 645463001820 Walker B; other site 645463001821 D-loop; other site 645463001822 H-loop/switch region; other site 645463001823 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645463001824 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645463001825 ligand binding site [chemical binding]; other site 645463001826 flexible hinge region; other site 645463001827 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645463001828 putative switch regulator; other site 645463001829 non-specific DNA interactions [nucleotide binding]; other site 645463001830 DNA binding site [nucleotide binding] 645463001831 sequence specific DNA binding site [nucleotide binding]; other site 645463001832 putative cAMP binding site [chemical binding]; other site 645463001833 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463001834 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463001835 Predicted transcriptional regulators [Transcription]; Region: COG1695 645463001836 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 645463001837 SnoaL-like domain; Region: SnoaL_2; pfam12680 645463001838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463001839 Putative lysophospholipase; Region: Hydrolase_4; cl19140 645463001840 Radical SAM superfamily; Region: Radical_SAM; pfam04055 645463001841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463001842 FeS/SAM binding site; other site 645463001843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463001844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463001845 Coenzyme A binding pocket [chemical binding]; other site 645463001846 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 645463001847 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 645463001848 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 645463001849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463001850 non-specific DNA binding site [nucleotide binding]; other site 645463001851 salt bridge; other site 645463001852 sequence-specific DNA binding site [nucleotide binding]; other site 645463001853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001855 active site 645463001856 phosphorylation site [posttranslational modification] 645463001857 intermolecular recognition site; other site 645463001858 dimerization interface [polypeptide binding]; other site 645463001859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001860 DNA binding site [nucleotide binding] 645463001861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463001862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001863 dimer interface [polypeptide binding]; other site 645463001864 phosphorylation site [posttranslational modification] 645463001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001866 ATP binding site [chemical binding]; other site 645463001867 Mg2+ binding site [ion binding]; other site 645463001868 G-X-G motif; other site 645463001869 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463001870 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463001871 Walker A/P-loop; other site 645463001872 ATP binding site [chemical binding]; other site 645463001873 Q-loop/lid; other site 645463001874 ABC transporter signature motif; other site 645463001875 Walker B; other site 645463001876 D-loop; other site 645463001877 H-loop/switch region; other site 645463001878 Fic family protein [Function unknown]; Region: COG3177 645463001879 Fic/DOC family; Region: Fic; pfam02661 645463001880 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645463001881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463001882 DNA-binding site [nucleotide binding]; DNA binding site 645463001883 FCD domain; Region: FCD; pfam07729 645463001884 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 645463001885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645463001886 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 645463001887 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 645463001888 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463001889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463001890 DNA-binding site [nucleotide binding]; DNA binding site 645463001891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463001892 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463001893 Walker A/P-loop; other site 645463001894 ATP binding site [chemical binding]; other site 645463001895 Q-loop/lid; other site 645463001896 ABC transporter signature motif; other site 645463001897 Walker B; other site 645463001898 D-loop; other site 645463001899 H-loop/switch region; other site 645463001900 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 645463001901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463001902 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 645463001903 Cl- selectivity filter; other site 645463001904 Cl- binding residues [ion binding]; other site 645463001905 pore gating glutamate residue; other site 645463001906 dimer interface [polypeptide binding]; other site 645463001907 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 645463001908 Penicillinase repressor; Region: Penicillinase_R; cl17580 645463001909 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645463001910 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 645463001911 DNA binding residues [nucleotide binding] 645463001912 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 645463001913 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 645463001914 Peptidase C80 family; Region: Peptidase_C80; pfam11713 645463001915 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 645463001916 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 645463001917 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463001918 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463001919 Holin family; Region: Phage_holin_4; cl01989 645463001920 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 645463001921 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 645463001922 Peptidase C80 family; Region: Peptidase_C80; pfam11713 645463001923 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 645463001924 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463001925 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463001926 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463001927 Pathogenicity locus; Region: Cdd1; pfam11731 645463001928 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 645463001929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 645463001930 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463001931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463001932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463001933 Walker A/P-loop; other site 645463001934 ATP binding site [chemical binding]; other site 645463001935 Q-loop/lid; other site 645463001936 ABC transporter signature motif; other site 645463001937 Walker B; other site 645463001938 D-loop; other site 645463001939 H-loop/switch region; other site 645463001940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463001941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463001942 active site 645463001943 phosphorylation site [posttranslational modification] 645463001944 intermolecular recognition site; other site 645463001945 dimerization interface [polypeptide binding]; other site 645463001946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463001947 DNA binding site [nucleotide binding] 645463001948 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 645463001949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463001950 dimer interface [polypeptide binding]; other site 645463001951 phosphorylation site [posttranslational modification] 645463001952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463001953 ATP binding site [chemical binding]; other site 645463001954 Mg2+ binding site [ion binding]; other site 645463001955 G-X-G motif; other site 645463001956 Penicillinase repressor; Region: Penicillinase_R; cl17580 645463001957 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 645463001958 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 645463001959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463001960 S-adenosylmethionine binding site [chemical binding]; other site 645463001961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463001962 Coenzyme A binding pocket [chemical binding]; other site 645463001963 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 645463001964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463001965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463001966 DNA binding residues [nucleotide binding] 645463001967 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 645463001968 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 645463001969 active site 645463001970 putative substrate binding pocket [chemical binding]; other site 645463001971 SnoaL-like domain; Region: SnoaL_2; pfam12680 645463001972 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 645463001973 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 645463001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463001975 benzoate transport; Region: 2A0115; TIGR00895 645463001976 putative substrate translocation pore; other site 645463001977 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463001978 Na binding site [ion binding]; other site 645463001979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463001980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463001981 DNA binding site [nucleotide binding] 645463001982 domain linker motif; other site 645463001983 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 645463001984 putative ligand binding site [chemical binding]; other site 645463001985 putative dimerization interface [polypeptide binding]; other site 645463001986 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 645463001987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463001988 Walker A motif; other site 645463001989 ATP binding site [chemical binding]; other site 645463001990 Walker B motif; other site 645463001991 arginine finger; other site 645463001992 Peptidase family M41; Region: Peptidase_M41; pfam01434 645463001993 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 645463001994 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 645463001995 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 645463001996 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 645463001997 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 645463001998 23S rRNA binding site [nucleotide binding]; other site 645463001999 L21 binding site [polypeptide binding]; other site 645463002000 L13 binding site [polypeptide binding]; other site 645463002001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463002002 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 645463002003 active site 645463002004 metal binding site [ion binding]; metal-binding site 645463002005 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 645463002006 active site 645463002007 metal binding site [ion binding]; metal-binding site 645463002008 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 645463002009 active site 645463002010 metal binding site [ion binding]; metal-binding site 645463002011 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 645463002012 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 645463002013 active site 645463002014 metal binding site [ion binding]; metal-binding site 645463002015 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 645463002016 classical (c) SDRs; Region: SDR_c; cd05233 645463002017 NAD(P) binding site [chemical binding]; other site 645463002018 active site 645463002019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 645463002020 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 645463002021 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645463002022 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463002023 DNA binding residues [nucleotide binding] 645463002024 drug binding residues [chemical binding]; other site 645463002025 dimer interface [polypeptide binding]; other site 645463002026 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463002027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463002028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463002029 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 645463002030 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 645463002031 active site 645463002032 Zn binding site [ion binding]; other site 645463002033 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 645463002034 Cation transport protein; Region: TrkH; cl17365 645463002035 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 645463002036 TrkA-N domain; Region: TrkA_N; pfam02254 645463002037 TrkA-C domain; Region: TrkA_C; pfam02080 645463002038 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 645463002039 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 645463002040 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 645463002041 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 645463002042 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 645463002043 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 645463002044 dimer interface [polypeptide binding]; other site 645463002045 motif 1; other site 645463002046 active site 645463002047 motif 2; other site 645463002048 motif 3; other site 645463002049 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 645463002050 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 645463002051 putative tRNA-binding site [nucleotide binding]; other site 645463002052 B3/4 domain; Region: B3_4; pfam03483 645463002053 tRNA synthetase B5 domain; Region: B5; smart00874 645463002054 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 645463002055 dimer interface [polypeptide binding]; other site 645463002056 motif 1; other site 645463002057 motif 3; other site 645463002058 motif 2; other site 645463002059 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 645463002060 Cell division protein ZapA; Region: ZapA; pfam05164 645463002061 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 645463002062 putative protease; Provisional; Region: PRK15452 645463002063 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 645463002064 Collagenase; Region: DUF3656; pfam12392 645463002065 Peptidase family U32; Region: Peptidase_U32; pfam01136 645463002066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645463002067 Zn2+ binding site [ion binding]; other site 645463002068 Mg2+ binding site [ion binding]; other site 645463002069 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 645463002070 putative active site [active] 645463002071 nucleotide binding site [chemical binding]; other site 645463002072 nudix motif; other site 645463002073 putative metal binding site [ion binding]; other site 645463002074 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 645463002075 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463002076 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463002077 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463002078 FMN binding site [chemical binding]; other site 645463002079 dimer interface [polypeptide binding]; other site 645463002080 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 645463002081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463002082 substrate binding pocket [chemical binding]; other site 645463002083 membrane-bound complex binding site; other site 645463002084 hinge residues; other site 645463002085 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463002086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463002087 substrate binding pocket [chemical binding]; other site 645463002088 membrane-bound complex binding site; other site 645463002089 hinge residues; other site 645463002090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002091 metal binding site [ion binding]; metal-binding site 645463002092 active site 645463002093 I-site; other site 645463002094 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 645463002095 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 645463002096 metal binding site [ion binding]; metal-binding site 645463002097 dimer interface [polypeptide binding]; other site 645463002098 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 645463002099 MutS domain III; Region: MutS_III; pfam05192 645463002100 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 645463002101 Walker A/P-loop; other site 645463002102 ATP binding site [chemical binding]; other site 645463002103 Q-loop/lid; other site 645463002104 ABC transporter signature motif; other site 645463002105 Walker B; other site 645463002106 D-loop; other site 645463002107 H-loop/switch region; other site 645463002108 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 645463002109 Smr domain; Region: Smr; pfam01713 645463002110 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 645463002111 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 645463002112 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 645463002113 active site 645463002114 HIGH motif; other site 645463002115 KMSK motif region; other site 645463002116 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 645463002117 tRNA binding surface [nucleotide binding]; other site 645463002118 anticodon binding site; other site 645463002119 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 645463002120 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 645463002121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463002122 FeS/SAM binding site; other site 645463002123 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 645463002124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463002125 binding surface 645463002126 TPR motif; other site 645463002127 TPR repeat; Region: TPR_11; pfam13414 645463002128 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 645463002129 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463002130 ACS interaction site; other site 645463002131 CODH interaction site; other site 645463002132 metal cluster binding site [ion binding]; other site 645463002133 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 645463002134 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 645463002135 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 645463002136 P-loop; other site 645463002137 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 645463002138 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 645463002139 Potassium binding sites [ion binding]; other site 645463002140 Cesium cation binding sites [ion binding]; other site 645463002141 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 645463002142 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 645463002143 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 645463002144 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 645463002145 homodimer interface [polypeptide binding]; other site 645463002146 NADP binding site [chemical binding]; other site 645463002147 substrate binding site [chemical binding]; other site 645463002148 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 645463002149 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 645463002150 FAD binding site [chemical binding]; other site 645463002151 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 645463002152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463002153 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 645463002154 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 645463002155 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 645463002156 P-loop; other site 645463002157 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 645463002158 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 645463002159 Putative Fe-S cluster; Region: FeS; pfam04060 645463002160 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 645463002161 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 645463002162 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 645463002163 substrate binding pocket [chemical binding]; other site 645463002164 dimer interface [polypeptide binding]; other site 645463002165 inhibitor binding site; inhibition site 645463002166 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 645463002167 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463002168 ACS interaction site; other site 645463002169 CODH interaction site; other site 645463002170 metal cluster binding site [ion binding]; other site 645463002171 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 645463002172 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 645463002173 lipoyl attachment site [posttranslational modification]; other site 645463002174 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 645463002175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463002176 catalytic loop [active] 645463002177 iron binding site [ion binding]; other site 645463002178 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 645463002179 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 645463002180 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463002181 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 645463002182 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 645463002183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463002184 FeS/SAM binding site; other site 645463002185 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645463002186 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 645463002187 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 645463002188 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 645463002189 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 645463002190 active site 645463002191 dimer interface [polypeptide binding]; other site 645463002192 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 645463002193 Domains similar to the Pancreatic-derived factor; Region: PANDER_like; cl19122 645463002194 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 645463002195 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463002196 catalytic residue [active] 645463002197 glycerol kinase; Provisional; Region: glpK; PRK00047 645463002198 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 645463002199 N- and C-terminal domain interface [polypeptide binding]; other site 645463002200 active site 645463002201 MgATP binding site [chemical binding]; other site 645463002202 catalytic site [active] 645463002203 metal binding site [ion binding]; metal-binding site 645463002204 glycerol binding site [chemical binding]; other site 645463002205 homotetramer interface [polypeptide binding]; other site 645463002206 homodimer interface [polypeptide binding]; other site 645463002207 FBP binding site [chemical binding]; other site 645463002208 protein IIAGlc interface [polypeptide binding]; other site 645463002209 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 645463002210 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645463002211 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645463002212 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645463002213 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 645463002214 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 645463002215 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 645463002216 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 645463002217 ligand binding site [chemical binding]; other site 645463002218 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645463002219 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 645463002220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002221 metal binding site [ion binding]; metal-binding site 645463002222 active site 645463002223 I-site; other site 645463002224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463002225 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645463002226 Part of AAA domain; Region: AAA_19; pfam13245 645463002227 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 645463002228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463002229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463002230 substrate binding pocket [chemical binding]; other site 645463002231 membrane-bound complex binding site; other site 645463002232 hinge residues; other site 645463002233 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645463002234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002235 dimer interface [polypeptide binding]; other site 645463002236 conserved gate region; other site 645463002237 putative PBP binding loops; other site 645463002238 ABC-ATPase subunit interface; other site 645463002239 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645463002240 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645463002241 Walker A/P-loop; other site 645463002242 ATP binding site [chemical binding]; other site 645463002243 Q-loop/lid; other site 645463002244 ABC transporter signature motif; other site 645463002245 Walker B; other site 645463002246 D-loop; other site 645463002247 H-loop/switch region; other site 645463002248 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 645463002249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463002250 catalytic residue [active] 645463002251 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 645463002252 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 645463002253 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 645463002254 Ligand Binding Site [chemical binding]; other site 645463002255 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 645463002256 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 645463002257 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463002258 FMN binding site [chemical binding]; other site 645463002259 dimer interface [polypeptide binding]; other site 645463002260 PAS fold; Region: PAS_3; pfam08447 645463002261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002262 metal binding site [ion binding]; metal-binding site 645463002263 active site 645463002264 I-site; other site 645463002265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463002266 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 645463002267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463002268 FeS/SAM binding site; other site 645463002269 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 645463002270 Pyruvate formate lyase 1; Region: PFL1; cd01678 645463002271 coenzyme A binding site [chemical binding]; other site 645463002272 active site 645463002273 catalytic residues [active] 645463002274 glycine loop; other site 645463002275 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 645463002276 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 645463002277 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 645463002278 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 645463002279 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645463002280 ATP binding site [chemical binding]; other site 645463002281 Mg++ binding site [ion binding]; other site 645463002282 motif III; other site 645463002283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463002284 nucleotide binding region [chemical binding]; other site 645463002285 ATP-binding site [chemical binding]; other site 645463002286 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 645463002287 RNA binding site [nucleotide binding]; other site 645463002288 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463002289 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463002290 PRD domain; Region: PRD; pfam00874 645463002291 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463002292 active site 645463002293 P-loop; other site 645463002294 phosphorylation site [posttranslational modification] 645463002295 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463002296 active site 645463002297 phosphorylation site [posttranslational modification] 645463002298 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 645463002299 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 645463002300 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 645463002301 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 645463002302 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 645463002303 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 645463002304 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 645463002305 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 645463002306 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 645463002307 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 645463002308 putative NAD(P) binding site [chemical binding]; other site 645463002309 active site 645463002310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463002311 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463002312 Probable transposase; Region: OrfB_IS605; pfam01385 645463002313 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463002314 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 645463002315 putative [4Fe-4S] binding site [ion binding]; other site 645463002316 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 645463002317 putative molybdopterin cofactor binding site [chemical binding]; other site 645463002318 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 645463002319 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 645463002320 anti sigma factor interaction site; other site 645463002321 regulatory phosphorylation site [posttranslational modification]; other site 645463002322 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 645463002323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463002324 ATP binding site [chemical binding]; other site 645463002325 Mg2+ binding site [ion binding]; other site 645463002326 G-X-G motif; other site 645463002327 sporulation sigma factor SigF; Validated; Region: PRK05572 645463002328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463002329 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463002330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463002331 DNA binding residues [nucleotide binding] 645463002332 SpoVA protein; Region: SpoVA; cl04298 645463002333 stage V sporulation protein AD; Validated; Region: PRK08304 645463002334 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 645463002335 SpoVA protein; Region: SpoVA; pfam03862 645463002336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463002337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463002338 DNA binding site [nucleotide binding] 645463002339 domain linker motif; other site 645463002340 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 645463002341 ligand binding site [chemical binding]; other site 645463002342 dimerization interface [polypeptide binding]; other site 645463002343 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 645463002344 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 645463002345 amidohydrolase; Region: amidohydrolases; TIGR01891 645463002346 metal binding site [ion binding]; metal-binding site 645463002347 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 645463002348 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 645463002349 active site 645463002350 catalytic motif [active] 645463002351 Zn binding site [ion binding]; other site 645463002352 Transglycosylase; Region: Transgly; pfam00912 645463002353 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 645463002354 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645463002355 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 645463002356 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 645463002357 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 645463002358 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463002359 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463002360 active site 645463002361 metal binding site [ion binding]; metal-binding site 645463002362 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645463002363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463002364 ABC transporter; Region: ABC_tran_2; pfam12848 645463002365 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463002366 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 645463002367 Cysteine-rich small domain; Region: zf-like; pfam04071 645463002368 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 645463002369 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 645463002370 HflX GTPase family; Region: HflX; cd01878 645463002371 G1 box; other site 645463002372 GTP/Mg2+ binding site [chemical binding]; other site 645463002373 Switch I region; other site 645463002374 G2 box; other site 645463002375 G3 box; other site 645463002376 Switch II region; other site 645463002377 G4 box; other site 645463002378 G5 box; other site 645463002379 HEAT repeats; Region: HEAT_2; pfam13646 645463002380 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 645463002381 active site 645463002382 Ap6A binding site [chemical binding]; other site 645463002383 nudix motif; other site 645463002384 metal binding site [ion binding]; metal-binding site 645463002385 Uncharacterized conserved protein [Function unknown]; Region: COG1739 645463002386 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 645463002387 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 645463002388 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645463002389 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645463002390 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 645463002391 homodimer interface [polypeptide binding]; other site 645463002392 NAD binding pocket [chemical binding]; other site 645463002393 ATP binding pocket [chemical binding]; other site 645463002394 Mg binding site [ion binding]; other site 645463002395 active-site loop [active] 645463002396 hypothetical protein; Validated; Region: PRK00110 645463002397 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463002398 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463002399 DNA binding site [nucleotide binding] 645463002400 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 645463002401 putative dimerization interface [polypeptide binding]; other site 645463002402 putative ligand binding site [chemical binding]; other site 645463002403 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 645463002404 active site 645463002405 catalytic residues [active] 645463002406 metal binding site [ion binding]; metal-binding site 645463002407 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 645463002408 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 645463002409 transmembrane helices; other site 645463002410 Citrate transporter; Region: CitMHS; pfam03600 645463002411 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 645463002412 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 645463002413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645463002414 substrate binding site [chemical binding]; other site 645463002415 oxyanion hole (OAH) forming residues; other site 645463002416 trimer interface [polypeptide binding]; other site 645463002417 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 645463002418 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645463002419 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 645463002420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645463002421 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 645463002422 active site 645463002423 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645463002424 Ligand binding site [chemical binding]; other site 645463002425 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645463002426 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 645463002427 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645463002428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463002429 PAS domain; Region: PAS_9; pfam13426 645463002430 putative active site [active] 645463002431 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 645463002432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463002433 Walker A motif; other site 645463002434 ATP binding site [chemical binding]; other site 645463002435 Walker B motif; other site 645463002436 arginine finger; other site 645463002437 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463002438 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002439 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002440 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002441 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002442 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002443 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463002444 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463002445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002446 metal binding site [ion binding]; metal-binding site 645463002447 active site 645463002448 I-site; other site 645463002449 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463002450 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 645463002451 Ligand Binding Site [chemical binding]; other site 645463002452 PTS system, Lactose/Cellobiose specific IIB subunit; Region: PTS_IIB; pfam02302 645463002453 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645463002454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463002455 DNA-binding site [nucleotide binding]; DNA binding site 645463002456 FCD domain; Region: FCD; pfam07729 645463002457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463002458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463002459 putative substrate translocation pore; other site 645463002460 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645463002461 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463002462 active site turn [active] 645463002463 phosphorylation site [posttranslational modification] 645463002464 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463002465 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463002466 HPr interaction site; other site 645463002467 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463002468 active site 645463002469 phosphorylation site [posttranslational modification] 645463002470 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645463002471 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463002472 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463002473 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463002474 PRD domain; Region: PRD; pfam00874 645463002475 PRD domain; Region: PRD; pfam00874 645463002476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463002477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463002478 active site 645463002479 phosphorylation site [posttranslational modification] 645463002480 intermolecular recognition site; other site 645463002481 dimerization interface [polypeptide binding]; other site 645463002482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463002483 DNA binding site [nucleotide binding] 645463002484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463002485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463002486 dimer interface [polypeptide binding]; other site 645463002487 phosphorylation site [posttranslational modification] 645463002488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463002489 ATP binding site [chemical binding]; other site 645463002490 Mg2+ binding site [ion binding]; other site 645463002491 G-X-G motif; other site 645463002492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463002493 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463002494 Walker A/P-loop; other site 645463002495 ATP binding site [chemical binding]; other site 645463002496 Q-loop/lid; other site 645463002497 ABC transporter signature motif; other site 645463002498 Walker B; other site 645463002499 D-loop; other site 645463002500 H-loop/switch region; other site 645463002501 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463002502 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463002503 Rubrerythrin [Energy production and conversion]; Region: COG1592 645463002504 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 645463002505 binuclear metal center [ion binding]; other site 645463002506 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 645463002507 iron binding site [ion binding]; other site 645463002508 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645463002509 metal binding site 2 [ion binding]; metal-binding site 645463002510 putative DNA binding helix; other site 645463002511 metal binding site 1 [ion binding]; metal-binding site 645463002512 dimer interface [polypeptide binding]; other site 645463002513 structural Zn2+ binding site [ion binding]; other site 645463002514 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 645463002515 non-heme iron binding site [ion binding]; other site 645463002516 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 645463002517 dimer interface [polypeptide binding]; other site 645463002518 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 645463002519 non-heme iron binding site [ion binding]; other site 645463002520 Rubredoxin [Energy production and conversion]; Region: COG1773 645463002521 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 645463002522 iron binding site [ion binding]; other site 645463002523 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 645463002524 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 645463002525 active site 645463002526 FMN binding site [chemical binding]; other site 645463002527 substrate binding site [chemical binding]; other site 645463002528 3Fe-4S cluster binding site [ion binding]; other site 645463002529 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 645463002530 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463002531 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645463002532 DEAD-like helicases superfamily; Region: DEXDc; smart00487 645463002533 ATP binding site [chemical binding]; other site 645463002534 Mg++ binding site [ion binding]; other site 645463002535 motif III; other site 645463002536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463002537 nucleotide binding region [chemical binding]; other site 645463002538 ATP-binding site [chemical binding]; other site 645463002539 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 645463002540 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 645463002541 active site 645463002542 catalytic residues [active] 645463002543 metal binding site [ion binding]; metal-binding site 645463002544 aconitate hydratase; Validated; Region: PRK07229 645463002545 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 645463002546 substrate binding site [chemical binding]; other site 645463002547 ligand binding site [chemical binding]; other site 645463002548 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 645463002549 substrate binding site [chemical binding]; other site 645463002550 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 645463002551 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463002552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463002553 dimerization interface [polypeptide binding]; other site 645463002554 putative Zn2+ binding site [ion binding]; other site 645463002555 putative DNA binding site [nucleotide binding]; other site 645463002556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 645463002557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463002558 Coenzyme A binding pocket [chemical binding]; other site 645463002559 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 645463002560 putative FMN binding site [chemical binding]; other site 645463002561 Trp repressor protein; Region: Trp_repressor; cl17266 645463002562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 645463002563 DNA binding site [nucleotide binding] 645463002564 CAAX protease self-immunity; Region: Abi; pfam02517 645463002565 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 645463002566 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 645463002567 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 645463002568 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 645463002569 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 645463002570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645463002571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 645463002572 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463002573 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463002574 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463002575 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 645463002576 GIY-YIG motif/motif A; other site 645463002577 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 645463002578 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 645463002579 amidohydrolase; Region: amidohydrolases; TIGR01891 645463002580 putative metal binding site [ion binding]; other site 645463002581 NifU-like domain; Region: NifU; cl00484 645463002582 TIGR03987 family protein; Region: TIGR03987 645463002583 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463002584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463002585 putative DNA binding site [nucleotide binding]; other site 645463002586 putative Zn2+ binding site [ion binding]; other site 645463002587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645463002588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002589 dimer interface [polypeptide binding]; other site 645463002590 conserved gate region; other site 645463002591 putative PBP binding loops; other site 645463002592 ABC-ATPase subunit interface; other site 645463002593 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 645463002594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002595 dimer interface [polypeptide binding]; other site 645463002596 conserved gate region; other site 645463002597 putative PBP binding loops; other site 645463002598 ABC-ATPase subunit interface; other site 645463002599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 645463002600 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 645463002601 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645463002602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645463002603 Walker A/P-loop; other site 645463002604 ATP binding site [chemical binding]; other site 645463002605 Q-loop/lid; other site 645463002606 ABC transporter signature motif; other site 645463002607 Walker B; other site 645463002608 D-loop; other site 645463002609 H-loop/switch region; other site 645463002610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645463002611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645463002612 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 645463002613 Walker A/P-loop; other site 645463002614 ATP binding site [chemical binding]; other site 645463002615 Q-loop/lid; other site 645463002616 ABC transporter signature motif; other site 645463002617 Walker B; other site 645463002618 D-loop; other site 645463002619 H-loop/switch region; other site 645463002620 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645463002621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463002622 putative DNA binding site [nucleotide binding]; other site 645463002623 putative Zn2+ binding site [ion binding]; other site 645463002624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463002625 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463002626 Walker A motif; other site 645463002627 ATP binding site [chemical binding]; other site 645463002628 Walker B motif; other site 645463002629 arginine finger; other site 645463002630 Transcriptional antiterminator [Transcription]; Region: COG3933 645463002631 PRD domain; Region: PRD; pfam00874 645463002632 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463002633 active pocket/dimerization site; other site 645463002634 active site 645463002635 phosphorylation site [posttranslational modification] 645463002636 PRD domain; Region: PRD; pfam00874 645463002637 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 645463002638 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463002639 active site 645463002640 P-loop; other site 645463002641 phosphorylation site [posttranslational modification] 645463002642 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463002643 methionine cluster; other site 645463002644 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 645463002645 active site 645463002646 phosphorylation site [posttranslational modification] 645463002647 metal binding site [ion binding]; metal-binding site 645463002648 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645463002649 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 645463002650 NAD binding site [chemical binding]; other site 645463002651 sugar binding site [chemical binding]; other site 645463002652 divalent metal binding site [ion binding]; other site 645463002653 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463002654 dimer interface [polypeptide binding]; other site 645463002655 hypothetical protein; Provisional; Region: PRK04143 645463002656 ADP-ribose binding site [chemical binding]; other site 645463002657 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 645463002658 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 645463002659 Helix-turn-helix domain; Region: HTH_17; pfam12728 645463002660 PBP superfamily domain; Region: PBP_like; pfam12727 645463002661 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 645463002662 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 645463002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002664 dimer interface [polypeptide binding]; other site 645463002665 conserved gate region; other site 645463002666 putative PBP binding loops; other site 645463002667 ABC-ATPase subunit interface; other site 645463002668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002669 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 645463002670 Walker A/P-loop; other site 645463002671 ATP binding site [chemical binding]; other site 645463002672 Q-loop/lid; other site 645463002673 ABC transporter signature motif; other site 645463002674 Walker B; other site 645463002675 D-loop; other site 645463002676 H-loop/switch region; other site 645463002677 maltose O-acetyltransferase; Provisional; Region: PRK10092 645463002678 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 645463002679 active site 645463002680 substrate binding site [chemical binding]; other site 645463002681 trimer interface [polypeptide binding]; other site 645463002682 CoA binding site [chemical binding]; other site 645463002683 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 645463002684 zinc binding site [ion binding]; other site 645463002685 putative ligand binding site [chemical binding]; other site 645463002686 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 645463002687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002688 Walker A/P-loop; other site 645463002689 ATP binding site [chemical binding]; other site 645463002690 Q-loop/lid; other site 645463002691 ABC transporter signature motif; other site 645463002692 Walker B; other site 645463002693 D-loop; other site 645463002694 H-loop/switch region; other site 645463002695 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 645463002696 TM-ABC transporter signature motif; other site 645463002697 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 645463002698 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 645463002699 zinc binding site [ion binding]; other site 645463002700 putative ligand binding site [chemical binding]; other site 645463002701 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 645463002702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002703 Walker A/P-loop; other site 645463002704 ATP binding site [chemical binding]; other site 645463002705 Q-loop/lid; other site 645463002706 ABC transporter signature motif; other site 645463002707 Walker B; other site 645463002708 D-loop; other site 645463002709 H-loop/switch region; other site 645463002710 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 645463002711 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 645463002712 TM-ABC transporter signature motif; other site 645463002713 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 645463002714 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 645463002715 putative substrate binding site [chemical binding]; other site 645463002716 putative ATP binding site [chemical binding]; other site 645463002717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463002718 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463002719 Probable transposase; Region: OrfB_IS605; pfam01385 645463002720 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463002721 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 645463002722 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 645463002723 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 645463002724 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 645463002725 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 645463002726 ligand binding site; other site 645463002727 oligomer interface; other site 645463002728 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 645463002729 dimer interface [polypeptide binding]; other site 645463002730 N-terminal domain interface [polypeptide binding]; other site 645463002731 sulfate 1 binding site; other site 645463002732 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 645463002733 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 645463002734 ligand binding site; other site 645463002735 oligomer interface; other site 645463002736 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 645463002737 dimer interface [polypeptide binding]; other site 645463002738 N-terminal domain interface [polypeptide binding]; other site 645463002739 sulfate 1 binding site; other site 645463002740 glycogen synthase; Provisional; Region: glgA; PRK00654 645463002741 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 645463002742 ADP-binding pocket [chemical binding]; other site 645463002743 homodimer interface [polypeptide binding]; other site 645463002744 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 645463002745 homodimer interface [polypeptide binding]; other site 645463002746 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 645463002747 active site pocket [active] 645463002748 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 645463002749 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 645463002750 active site 645463002751 homodimer interface [polypeptide binding]; other site 645463002752 catalytic site [active] 645463002753 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 645463002754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463002755 DNA-binding site [nucleotide binding]; DNA binding site 645463002756 FCD domain; Region: FCD; pfam07729 645463002757 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 645463002758 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 645463002759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463002760 catalytic residue [active] 645463002761 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 645463002762 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 645463002763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463002764 S-adenosylmethionine binding site [chemical binding]; other site 645463002765 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 645463002766 putative active site [active] 645463002767 Mn binding site [ion binding]; other site 645463002768 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645463002769 DNA-binding site [nucleotide binding]; DNA binding site 645463002770 RNA-binding motif; other site 645463002771 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 645463002772 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463002773 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463002774 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 645463002775 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 645463002776 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463002777 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 645463002778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 645463002779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463002780 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463002781 Probable transposase; Region: OrfB_IS605; pfam01385 645463002782 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463002783 isoleucine-tRNA ligase, putative; Provisional; Region: PTZ00427 645463002784 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 645463002785 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 645463002786 active site 645463002787 DNA polymerase IV; Validated; Region: PRK02406 645463002788 DNA binding site [nucleotide binding] 645463002789 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 645463002790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002791 Walker A/P-loop; other site 645463002792 ATP binding site [chemical binding]; other site 645463002793 Q-loop/lid; other site 645463002794 ABC transporter signature motif; other site 645463002795 Walker B; other site 645463002796 D-loop; other site 645463002797 H-loop/switch region; other site 645463002798 FOG: CBS domain [General function prediction only]; Region: COG0517 645463002799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 645463002800 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 645463002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002802 dimer interface [polypeptide binding]; other site 645463002803 conserved gate region; other site 645463002804 putative PBP binding loops; other site 645463002805 ABC-ATPase subunit interface; other site 645463002806 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645463002807 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645463002808 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 645463002809 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645463002810 active site 645463002811 catalytic tetrad [active] 645463002812 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 645463002813 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 645463002814 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 645463002815 putative active site [active] 645463002816 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463002817 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 645463002818 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463002819 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463002820 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 645463002821 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 645463002822 RNA binding site [nucleotide binding]; other site 645463002823 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 645463002824 RNA binding site [nucleotide binding]; other site 645463002825 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 645463002826 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 645463002827 RNA binding site [nucleotide binding]; other site 645463002828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 645463002829 RNA binding site [nucleotide binding]; other site 645463002830 putative hydrolase; Validated; Region: PRK09248 645463002831 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 645463002832 active site 645463002833 2-isopropylmalate synthase; Validated; Region: PRK03739 645463002834 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 645463002835 active site 645463002836 catalytic residues [active] 645463002837 metal binding site [ion binding]; metal-binding site 645463002838 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 645463002839 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 645463002840 substrate binding site [chemical binding]; other site 645463002841 ligand binding site [chemical binding]; other site 645463002842 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 645463002843 substrate binding site [chemical binding]; other site 645463002844 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 645463002845 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 645463002846 CoenzymeA binding site [chemical binding]; other site 645463002847 subunit interaction site [polypeptide binding]; other site 645463002848 PHB binding site; other site 645463002849 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 645463002850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463002851 catalytic residue [active] 645463002852 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 645463002853 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 645463002854 putative ligand binding site [chemical binding]; other site 645463002855 NAD binding site [chemical binding]; other site 645463002856 dimerization interface [polypeptide binding]; other site 645463002857 catalytic site [active] 645463002858 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 645463002859 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645463002860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463002861 putative active site [active] 645463002862 heme pocket [chemical binding]; other site 645463002863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463002864 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645463002865 putative active site [active] 645463002866 heme pocket [chemical binding]; other site 645463002867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463002868 heme pocket [chemical binding]; other site 645463002869 putative active site [active] 645463002870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002871 metal binding site [ion binding]; metal-binding site 645463002872 active site 645463002873 I-site; other site 645463002874 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 645463002875 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 645463002876 hypothetical protein; Provisional; Region: PRK00955 645463002877 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 645463002878 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 645463002879 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 645463002880 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 645463002881 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645463002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463002883 dimer interface [polypeptide binding]; other site 645463002884 conserved gate region; other site 645463002885 putative PBP binding loops; other site 645463002886 ABC-ATPase subunit interface; other site 645463002887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002888 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463002889 Walker A/P-loop; other site 645463002890 ATP binding site [chemical binding]; other site 645463002891 Q-loop/lid; other site 645463002892 ABC transporter signature motif; other site 645463002893 Walker B; other site 645463002894 D-loop; other site 645463002895 H-loop/switch region; other site 645463002896 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 645463002897 putative deacylase active site [active] 645463002898 fumarate hydratase; Provisional; Region: PRK06246 645463002899 Fumarase C-terminus; Region: Fumerase_C; cl00795 645463002900 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 645463002901 Malic enzyme, N-terminal domain; Region: malic; pfam00390 645463002902 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 645463002903 putative NAD(P) binding site [chemical binding]; other site 645463002904 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 645463002905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463002906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463002907 active site 645463002908 phosphorylation site [posttranslational modification] 645463002909 intermolecular recognition site; other site 645463002910 dimerization interface [polypeptide binding]; other site 645463002911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463002912 DNA binding site [nucleotide binding] 645463002913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463002914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463002915 dimer interface [polypeptide binding]; other site 645463002916 phosphorylation site [posttranslational modification] 645463002917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463002918 ATP binding site [chemical binding]; other site 645463002919 Mg2+ binding site [ion binding]; other site 645463002920 G-X-G motif; other site 645463002921 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463002922 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463002923 Walker A/P-loop; other site 645463002924 ATP binding site [chemical binding]; other site 645463002925 Q-loop/lid; other site 645463002926 ABC transporter signature motif; other site 645463002927 Walker B; other site 645463002928 D-loop; other site 645463002929 H-loop/switch region; other site 645463002930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463002931 FtsX-like permease family; Region: FtsX; pfam02687 645463002932 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463002933 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463002934 FtsX-like permease family; Region: FtsX; pfam02687 645463002935 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 645463002936 S1 domain; Region: S1_2; pfam13509 645463002937 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463002938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463002939 DNA-binding site [nucleotide binding]; DNA binding site 645463002940 UTRA domain; Region: UTRA; pfam07702 645463002941 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 645463002942 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 645463002943 active site 645463002944 dimer interface [polypeptide binding]; other site 645463002945 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 645463002946 active site 645463002947 trimer interface [polypeptide binding]; other site 645463002948 allosteric site; other site 645463002949 active site lid [active] 645463002950 hexamer (dimer of trimers) interface [polypeptide binding]; other site 645463002951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463002952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463002953 active site 645463002954 phosphorylation site [posttranslational modification] 645463002955 intermolecular recognition site; other site 645463002956 dimerization interface [polypeptide binding]; other site 645463002957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463002958 DNA binding site [nucleotide binding] 645463002959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463002960 HAMP domain; Region: HAMP; pfam00672 645463002961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463002962 dimer interface [polypeptide binding]; other site 645463002963 phosphorylation site [posttranslational modification] 645463002964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463002965 ATP binding site [chemical binding]; other site 645463002966 Mg2+ binding site [ion binding]; other site 645463002967 G-X-G motif; other site 645463002968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463002969 PAS fold; Region: PAS_3; pfam08447 645463002970 putative active site [active] 645463002971 heme pocket [chemical binding]; other site 645463002972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463002973 metal binding site [ion binding]; metal-binding site 645463002974 active site 645463002975 I-site; other site 645463002976 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463002977 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 645463002978 DNA binding residues [nucleotide binding] 645463002979 dimer interface [polypeptide binding]; other site 645463002980 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463002981 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463002982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463002983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463002984 Walker A/P-loop; other site 645463002985 ATP binding site [chemical binding]; other site 645463002986 Q-loop/lid; other site 645463002987 ABC transporter signature motif; other site 645463002988 Walker B; other site 645463002989 D-loop; other site 645463002990 H-loop/switch region; other site 645463002991 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463002992 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463002993 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645463002994 Walker A/P-loop; other site 645463002995 ATP binding site [chemical binding]; other site 645463002996 Q-loop/lid; other site 645463002997 ABC transporter signature motif; other site 645463002998 Walker B; other site 645463002999 D-loop; other site 645463003000 H-loop/switch region; other site 645463003001 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 645463003002 putative metal binding residues [ion binding]; other site 645463003003 signature motif; other site 645463003004 dimer interface [polypeptide binding]; other site 645463003005 active site 645463003006 polyP binding site; other site 645463003007 substrate binding site [chemical binding]; other site 645463003008 acceptor-phosphate pocket; other site 645463003009 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 645463003010 CotH protein; Region: CotH; pfam08757 645463003011 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463003012 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463003013 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463003014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463003015 non-specific DNA binding site [nucleotide binding]; other site 645463003016 salt bridge; other site 645463003017 sequence-specific DNA binding site [nucleotide binding]; other site 645463003018 Cupin domain; Region: Cupin_2; pfam07883 645463003019 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 645463003020 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 645463003021 Walker A/P-loop; other site 645463003022 ATP binding site [chemical binding]; other site 645463003023 Q-loop/lid; other site 645463003024 ABC transporter signature motif; other site 645463003025 Walker B; other site 645463003026 D-loop; other site 645463003027 H-loop/switch region; other site 645463003028 TOBE domain; Region: TOBE_2; pfam08402 645463003029 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 645463003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463003031 dimer interface [polypeptide binding]; other site 645463003032 conserved gate region; other site 645463003033 putative PBP binding loops; other site 645463003034 ABC-ATPase subunit interface; other site 645463003035 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 645463003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463003037 dimer interface [polypeptide binding]; other site 645463003038 conserved gate region; other site 645463003039 putative PBP binding loops; other site 645463003040 ABC-ATPase subunit interface; other site 645463003041 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 645463003042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 645463003043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463003044 metal binding site [ion binding]; metal-binding site 645463003045 active site 645463003046 I-site; other site 645463003047 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 645463003048 NodB motif; other site 645463003049 putative active site [active] 645463003050 putative catalytic site [active] 645463003051 putative Zn binding site [ion binding]; other site 645463003052 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 645463003053 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 645463003054 DXD motif; other site 645463003055 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 645463003056 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 645463003057 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 645463003058 active site 645463003059 homodimer interface [polypeptide binding]; other site 645463003060 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 645463003061 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003062 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003063 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003064 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463003065 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463003066 active site 645463003067 metal binding site [ion binding]; metal-binding site 645463003068 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003069 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003070 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003071 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463003072 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463003073 active site 645463003074 metal binding site [ion binding]; metal-binding site 645463003075 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 645463003076 Part of AAA domain; Region: AAA_19; pfam13245 645463003077 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 645463003078 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645463003079 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 645463003080 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 645463003081 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645463003082 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 645463003083 Part of AAA domain; Region: AAA_19; pfam13245 645463003084 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 645463003085 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 645463003086 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 645463003087 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 645463003088 active site 645463003089 metal binding site [ion binding]; metal-binding site 645463003090 DNA binding site [nucleotide binding] 645463003091 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 645463003092 exonuclease SbcC; Region: sbcc; TIGR00618 645463003093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463003094 Walker A/P-loop; other site 645463003095 ATP binding site [chemical binding]; other site 645463003096 Q-loop/lid; other site 645463003097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463003098 ABC transporter signature motif; other site 645463003099 Walker B; other site 645463003100 D-loop; other site 645463003101 H-loop/switch region; other site 645463003102 Domain of unknown function DUF21; Region: DUF21; pfam01595 645463003103 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645463003104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645463003105 Transporter associated domain; Region: CorC_HlyC; smart01091 645463003106 peptidase T-like protein; Region: PepT-like; TIGR01883 645463003107 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 645463003108 metal binding site [ion binding]; metal-binding site 645463003109 dimer interface [polypeptide binding]; other site 645463003110 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003111 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003112 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003113 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 645463003114 active site 645463003115 metal binding site [ion binding]; metal-binding site 645463003116 homotetramer interface [polypeptide binding]; other site 645463003117 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 645463003118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463003119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463003120 Walker A/P-loop; other site 645463003121 ATP binding site [chemical binding]; other site 645463003122 Q-loop/lid; other site 645463003123 ABC transporter signature motif; other site 645463003124 Walker B; other site 645463003125 D-loop; other site 645463003126 H-loop/switch region; other site 645463003127 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 645463003128 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 645463003129 putative deacylase active site [active] 645463003130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 645463003131 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 645463003132 FAD binding site [chemical binding]; other site 645463003133 homotetramer interface [polypeptide binding]; other site 645463003134 substrate binding pocket [chemical binding]; other site 645463003135 catalytic base [active] 645463003136 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645463003137 Ligand binding site [chemical binding]; other site 645463003138 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645463003139 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 645463003140 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645463003141 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 645463003142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 645463003143 substrate binding site [chemical binding]; other site 645463003144 oxyanion hole (OAH) forming residues; other site 645463003145 trimer interface [polypeptide binding]; other site 645463003146 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 645463003147 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 645463003148 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 645463003149 putative acyltransferase; Provisional; Region: PRK05790 645463003150 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645463003151 dimer interface [polypeptide binding]; other site 645463003152 active site 645463003153 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 645463003154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645463003155 active site 645463003156 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 645463003157 acyl carrier protein; Provisional; Region: acpP; PRK00982 645463003158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463003159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463003160 DNA binding site [nucleotide binding] 645463003161 domain linker motif; other site 645463003162 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 645463003163 dimerization interface [polypeptide binding]; other site 645463003164 effector binding site; other site 645463003165 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645463003166 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463003167 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 645463003168 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 645463003169 active site 645463003170 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645463003171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463003172 DNA-binding site [nucleotide binding]; DNA binding site 645463003173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463003174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463003175 homodimer interface [polypeptide binding]; other site 645463003176 catalytic residue [active] 645463003177 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 645463003178 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 645463003179 oligomer interface [polypeptide binding]; other site 645463003180 putative active site [active] 645463003181 metal binding site [ion binding]; metal-binding site 645463003182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463003183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463003184 DNA-binding site [nucleotide binding]; DNA binding site 645463003185 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 645463003186 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645463003187 active pocket/dimerization site; other site 645463003188 active site 645463003189 phosphorylation site [posttranslational modification] 645463003190 BtpA family; Region: BtpA; cl00440 645463003191 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 645463003192 active site 645463003193 phosphorylation site [posttranslational modification] 645463003194 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 645463003195 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 645463003196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463003197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463003198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 645463003199 dimerization interface [polypeptide binding]; other site 645463003200 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 645463003201 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 645463003202 dimer interface [polypeptide binding]; other site 645463003203 putative functional site; other site 645463003204 putative MPT binding site; other site 645463003205 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 645463003206 Walker A motif; other site 645463003207 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 645463003208 active site 645463003209 P-loop; other site 645463003210 phosphorylation site [posttranslational modification] 645463003211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463003212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463003213 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 645463003214 Walker A/P-loop; other site 645463003215 ATP binding site [chemical binding]; other site 645463003216 Q-loop/lid; other site 645463003217 ABC transporter signature motif; other site 645463003218 Walker B; other site 645463003219 D-loop; other site 645463003220 H-loop/switch region; other site 645463003221 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 645463003222 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463003223 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 645463003224 metal binding site [ion binding]; metal-binding site 645463003225 putative dimer interface [polypeptide binding]; other site 645463003226 zinc transporter ZupT; Provisional; Region: PRK04201 645463003227 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 645463003228 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463003229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463003230 active site 645463003231 phosphorylation site [posttranslational modification] 645463003232 intermolecular recognition site; other site 645463003233 dimerization interface [polypeptide binding]; other site 645463003234 LytTr DNA-binding domain; Region: LytTR; smart00850 645463003235 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 645463003236 GHKL domain; Region: HATPase_c_5; pfam14501 645463003237 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 645463003238 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 645463003239 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 645463003240 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 645463003241 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 645463003242 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463003243 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463003244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463003245 non-specific DNA binding site [nucleotide binding]; other site 645463003246 salt bridge; other site 645463003247 sequence-specific DNA binding site [nucleotide binding]; other site 645463003248 Cupin domain; Region: Cupin_2; pfam07883 645463003249 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645463003250 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 645463003251 putative active site [active] 645463003252 putative metal binding site [ion binding]; other site 645463003253 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 645463003254 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 645463003255 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463003256 FMN binding site [chemical binding]; other site 645463003257 dimer interface [polypeptide binding]; other site 645463003258 Nitroreductase family; Region: Nitroreductase; pfam00881 645463003259 FMN binding site [chemical binding]; other site 645463003260 dimer interface [polypeptide binding]; other site 645463003261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463003262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 645463003264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463003265 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463003266 Probable transposase; Region: OrfB_IS605; pfam01385 645463003267 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463003268 DHHW protein; Region: DHHW; pfam14286 645463003269 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 645463003270 DNA polymerase I; Provisional; Region: PRK05755 645463003271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 645463003272 active site 645463003273 metal binding site 1 [ion binding]; metal-binding site 645463003274 putative 5' ssDNA interaction site; other site 645463003275 metal binding site 3; metal-binding site 645463003276 metal binding site 2 [ion binding]; metal-binding site 645463003277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 645463003278 putative DNA binding site [nucleotide binding]; other site 645463003279 putative metal binding site [ion binding]; other site 645463003280 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 645463003281 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 645463003282 active site 645463003283 DNA binding site [nucleotide binding] 645463003284 catalytic site [active] 645463003285 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 645463003286 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 645463003287 CoA-binding site [chemical binding]; other site 645463003288 ATP-binding [chemical binding]; other site 645463003289 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 645463003290 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 645463003291 N-acetyl-D-glucosamine binding site [chemical binding]; other site 645463003292 catalytic residue [active] 645463003293 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 645463003294 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 645463003295 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645463003296 metal-binding site [ion binding] 645463003297 S-adenosylmethionine synthetase; Provisional; Region: PTZ00104 645463003298 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 645463003299 dimer interface [polypeptide binding]; other site 645463003300 active site 645463003301 metal binding site [ion binding]; metal-binding site 645463003302 glutathione binding site [chemical binding]; other site 645463003303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 645463003304 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003305 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003306 Bacterial SH3 domain homologues; Region: SH3b; smart00287 645463003307 Src Homology 3 domain superfamily; Region: SH3; cd00174 645463003308 peptide ligand binding site [polypeptide binding]; other site 645463003309 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645463003310 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463003311 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 645463003312 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 645463003313 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 645463003314 SLBB domain; Region: SLBB; pfam10531 645463003315 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 645463003316 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 645463003317 FMN-binding domain; Region: FMN_bind; cl01081 645463003318 electron transport complex RsxE subunit; Provisional; Region: PRK12405 645463003319 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 645463003320 ferredoxin; Validated; Region: PRK07118 645463003321 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 645463003322 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463003323 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463003324 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 645463003325 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 645463003326 active site 645463003327 dimer interface [polypeptide binding]; other site 645463003328 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 645463003329 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 645463003330 MPN+ (JAMM) motif; other site 645463003331 Zinc-binding site [ion binding]; other site 645463003332 rod shape-determining protein MreB; Provisional; Region: PRK13927 645463003333 MreB and similar proteins; Region: MreB_like; cd10225 645463003334 nucleotide binding site [chemical binding]; other site 645463003335 Mg binding site [ion binding]; other site 645463003336 putative protofilament interaction site [polypeptide binding]; other site 645463003337 RodZ interaction site [polypeptide binding]; other site 645463003338 rod shape-determining protein MreC; Provisional; Region: PRK13922 645463003339 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 645463003340 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 645463003341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645463003342 septum formation inhibitor; Reviewed; Region: minC; PRK00513 645463003343 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 645463003344 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 645463003345 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 645463003346 P-loop; other site 645463003347 ADP binding residues [chemical binding]; other site 645463003348 Switch I; other site 645463003349 Switch II; other site 645463003350 cell division topological specificity factor MinE; Provisional; Region: PRK13987 645463003351 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 645463003352 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 645463003353 active site 645463003354 dimer interfaces [polypeptide binding]; other site 645463003355 catalytic residues [active] 645463003356 Transcriptional regulator PadR-like family; Region: PadR; cl17335 645463003357 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 645463003358 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 645463003359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463003360 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 645463003361 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 645463003362 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 645463003363 B12 binding site [chemical binding]; other site 645463003364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463003365 FeS/SAM binding site; other site 645463003366 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 645463003367 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 645463003368 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 645463003369 homodimer interface [polypeptide binding]; other site 645463003370 oligonucleotide binding site [chemical binding]; other site 645463003371 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 645463003372 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 645463003373 Protein of unknown function (DUF464); Region: DUF464; pfam04327 645463003374 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 645463003375 GTPase CgtA; Reviewed; Region: obgE; PRK12297 645463003376 GTP1/OBG; Region: GTP1_OBG; pfam01018 645463003377 Obg GTPase; Region: Obg; cd01898 645463003378 G1 box; other site 645463003379 GTP/Mg2+ binding site [chemical binding]; other site 645463003380 Switch I region; other site 645463003381 G2 box; other site 645463003382 G3 box; other site 645463003383 Switch II region; other site 645463003384 G4 box; other site 645463003385 G5 box; other site 645463003386 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 645463003387 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 645463003388 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 645463003389 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 645463003390 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 645463003391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463003392 active site 645463003393 DNA binding site [nucleotide binding] 645463003394 Int/Topo IB signature motif; other site 645463003395 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 645463003396 Nucleoside recognition; Region: Gate; pfam07670 645463003397 Transcriptional regulators [Transcription]; Region: FadR; COG2186 645463003398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463003399 DNA-binding site [nucleotide binding]; DNA binding site 645463003400 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 645463003401 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 645463003402 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 645463003403 Ligand binding site [chemical binding]; other site 645463003404 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 645463003405 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 645463003406 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 645463003407 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 645463003408 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 645463003409 FAD binding domain; Region: FAD_binding_4; pfam01565 645463003410 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 645463003411 hypothetical protein; Provisional; Region: PRK13670 645463003412 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 645463003413 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 645463003414 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 645463003415 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 645463003416 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 645463003417 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645463003418 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 645463003419 putative phosphate acyltransferase; Provisional; Region: PRK05331 645463003420 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 645463003421 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 645463003422 dimer interface [polypeptide binding]; other site 645463003423 active site 645463003424 CoA binding pocket [chemical binding]; other site 645463003425 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 645463003426 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 645463003427 FMN binding site [chemical binding]; other site 645463003428 substrate binding site [chemical binding]; other site 645463003429 putative catalytic residue [active] 645463003430 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 645463003431 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 645463003432 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 645463003433 NAD(P) binding site [chemical binding]; other site 645463003434 homotetramer interface [polypeptide binding]; other site 645463003435 homodimer interface [polypeptide binding]; other site 645463003436 active site 645463003437 acyl carrier protein; Provisional; Region: acpP; PRK00982 645463003438 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 645463003439 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 645463003440 dimer interface [polypeptide binding]; other site 645463003441 active site 645463003442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463003443 metal binding site [ion binding]; metal-binding site 645463003444 active site 645463003445 I-site; other site 645463003446 PAS domain; Region: PAS; smart00091 645463003447 PAS domain S-box; Region: sensory_box; TIGR00229 645463003448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463003449 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463003450 Walker A motif; other site 645463003451 ATP binding site [chemical binding]; other site 645463003452 Walker B motif; other site 645463003453 arginine finger; other site 645463003454 TSCPD domain; Region: TSCPD; cl14834 645463003455 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 645463003456 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 645463003457 catalytic triad [active] 645463003458 amino acid transporter; Region: 2A0306; TIGR00909 645463003459 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463003460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463003461 Coenzyme A binding pocket [chemical binding]; other site 645463003462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463003463 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 645463003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 645463003465 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 645463003466 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 645463003467 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 645463003468 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 645463003469 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 645463003470 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 645463003471 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 645463003472 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 645463003473 Asp23 family; Region: Asp23; pfam03780 645463003474 transcription antitermination factor NusB; Region: nusB; TIGR01951 645463003475 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 645463003476 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 645463003477 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 645463003478 generic binding surface II; other site 645463003479 generic binding surface I; other site 645463003480 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 645463003481 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 645463003482 substrate binding pocket [chemical binding]; other site 645463003483 chain length determination region; other site 645463003484 substrate-Mg2+ binding site; other site 645463003485 catalytic residues [active] 645463003486 aspartate-rich region 1; other site 645463003487 active site lid residues [active] 645463003488 aspartate-rich region 2; other site 645463003489 Divergent PAP2 family; Region: DUF212; pfam02681 645463003490 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 645463003491 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 645463003492 TPP-binding site; other site 645463003493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645463003494 PYR/PP interface [polypeptide binding]; other site 645463003495 dimer interface [polypeptide binding]; other site 645463003496 TPP binding site [chemical binding]; other site 645463003497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463003498 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 645463003499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463003500 RNA binding surface [nucleotide binding]; other site 645463003501 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 645463003502 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 645463003503 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 645463003504 Walker A/P-loop; other site 645463003505 ATP binding site [chemical binding]; other site 645463003506 Q-loop/lid; other site 645463003507 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 645463003508 ABC transporter signature motif; other site 645463003509 Walker B; other site 645463003510 D-loop; other site 645463003511 H-loop/switch region; other site 645463003512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463003513 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463003514 Coenzyme A binding pocket [chemical binding]; other site 645463003515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645463003516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463003517 Coenzyme A binding pocket [chemical binding]; other site 645463003518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463003519 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 645463003520 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 645463003521 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 645463003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463003523 active site 645463003524 phosphorylation site [posttranslational modification] 645463003525 intermolecular recognition site; other site 645463003526 dimerization interface [polypeptide binding]; other site 645463003527 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 645463003528 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 645463003529 Thiamine pyrophosphokinase; Region: TPK; cd07995 645463003530 active site 645463003531 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 645463003532 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 645463003533 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463003534 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 645463003535 Ligand binding site; other site 645463003536 Putative Catalytic site; other site 645463003537 DXD motif; other site 645463003538 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 645463003539 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 645463003540 dimer interface [polypeptide binding]; other site 645463003541 ADP-ribose binding site [chemical binding]; other site 645463003542 active site 645463003543 nudix motif; other site 645463003544 metal binding site [ion binding]; metal-binding site 645463003545 Integral membrane protein DUF95; Region: DUF95; cl00572 645463003546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463003547 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 645463003548 active site 645463003549 DNA binding site [nucleotide binding] 645463003550 Int/Topo IB signature motif; other site 645463003551 phosphopentomutase; Provisional; Region: PRK05362 645463003552 purine nucleoside phosphorylase; Provisional; Region: PRK08202 645463003553 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 645463003554 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 645463003555 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 645463003556 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 645463003557 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 645463003558 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 645463003559 dimerization interface [polypeptide binding]; other site 645463003560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463003561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463003562 S-adenosylmethionine binding site [chemical binding]; other site 645463003563 putative protease; Provisional; Region: PRK15452 645463003564 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 645463003565 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 645463003566 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645463003567 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645463003568 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463003569 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 645463003570 Recombinase; Region: Recombinase; pfam07508 645463003571 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463003572 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 645463003573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463003574 TPR motif; other site 645463003575 TPR repeat; Region: TPR_11; pfam13414 645463003576 binding surface 645463003577 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003578 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003579 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463003580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463003581 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463003582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463003583 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463003584 putative transposase OrfB; Reviewed; Region: PHA02517 645463003585 HTH-like domain; Region: HTH_21; pfam13276 645463003586 Integrase core domain; Region: rve; pfam00665 645463003587 Integrase core domain; Region: rve_2; pfam13333 645463003588 VanZ like family; Region: VanZ; pfam04892 645463003589 elongation factor P; Validated; Region: PRK00529 645463003590 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 645463003591 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 645463003592 RNA binding site [nucleotide binding]; other site 645463003593 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 645463003594 RNA binding site [nucleotide binding]; other site 645463003595 Phage terminase large subunit (GpA); Region: Terminase_GpA; cl19377 645463003596 ribonuclease III; Reviewed; Region: rnc; PRK00102 645463003597 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 645463003598 dimerization interface [polypeptide binding]; other site 645463003599 active site 645463003600 metal binding site [ion binding]; metal-binding site 645463003601 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 645463003602 dsRNA binding site [nucleotide binding]; other site 645463003603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463003604 Radical SAM superfamily; Region: Radical_SAM; pfam04055 645463003605 FeS/SAM binding site; other site 645463003606 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 645463003607 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645463003608 Walker A/P-loop; other site 645463003609 ATP binding site [chemical binding]; other site 645463003610 Q-loop/lid; other site 645463003611 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 645463003612 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 645463003613 ABC transporter signature motif; other site 645463003614 Walker B; other site 645463003615 D-loop; other site 645463003616 H-loop/switch region; other site 645463003617 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 645463003618 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 645463003619 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 645463003620 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 645463003621 putative DNA-binding protein; Validated; Region: PRK00118 645463003622 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645463003623 signal recognition particle protein; Provisional; Region: PRK10867 645463003624 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 645463003625 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 645463003626 P loop; other site 645463003627 GTP binding site [chemical binding]; other site 645463003628 Signal peptide binding domain; Region: SRP_SPB; pfam02978 645463003629 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 645463003630 KH domain; Region: KH_4; pfam13083 645463003631 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 645463003632 RimM N-terminal domain; Region: RimM; pfam01782 645463003633 PRC-barrel domain; Region: PRC; pfam05239 645463003634 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 645463003635 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 645463003636 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 645463003637 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 645463003638 GTP/Mg2+ binding site [chemical binding]; other site 645463003639 G4 box; other site 645463003640 G5 box; other site 645463003641 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 645463003642 G1 box; other site 645463003643 G1 box; other site 645463003644 GTP/Mg2+ binding site [chemical binding]; other site 645463003645 G2 box; other site 645463003646 Switch I region; other site 645463003647 Switch I region; other site 645463003648 G2 box; other site 645463003649 G3 box; other site 645463003650 G3 box; other site 645463003651 Switch II region; other site 645463003652 Switch II region; other site 645463003653 G4 box; other site 645463003654 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 645463003655 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 645463003656 ATP cone domain; Region: ATP-cone; pfam03477 645463003657 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 645463003658 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 645463003659 active site 645463003660 dimer interface [polypeptide binding]; other site 645463003661 effector binding site; other site 645463003662 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 645463003663 RNA/DNA hybrid binding site [nucleotide binding]; other site 645463003664 active site 645463003665 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 645463003666 active site 645463003667 substrate binding site [chemical binding]; other site 645463003668 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 645463003669 FMN binding site [chemical binding]; other site 645463003670 putative catalytic residues [active] 645463003671 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 645463003672 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463003673 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463003674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463003675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463003676 Walker A/P-loop; other site 645463003677 ATP binding site [chemical binding]; other site 645463003678 Q-loop/lid; other site 645463003679 ABC transporter signature motif; other site 645463003680 Walker B; other site 645463003681 D-loop; other site 645463003682 H-loop/switch region; other site 645463003683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645463003684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463003685 active site 645463003686 phosphorylation site [posttranslational modification] 645463003687 intermolecular recognition site; other site 645463003688 dimerization interface [polypeptide binding]; other site 645463003689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645463003690 DNA binding residues [nucleotide binding] 645463003691 dimerization interface [polypeptide binding]; other site 645463003692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645463003693 Histidine kinase; Region: HisKA_3; pfam07730 645463003694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463003695 ATP binding site [chemical binding]; other site 645463003696 Mg2+ binding site [ion binding]; other site 645463003697 G-X-G motif; other site 645463003698 hypothetical protein; Reviewed; Region: PRK12497 645463003699 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 645463003700 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 645463003701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463003702 Walker A motif; other site 645463003703 ATP binding site [chemical binding]; other site 645463003704 Walker B motif; other site 645463003705 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 645463003706 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 645463003707 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 645463003708 DNA topoisomerase I; Validated; Region: PRK05582 645463003709 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 645463003710 active site 645463003711 interdomain interaction site; other site 645463003712 putative metal-binding site [ion binding]; other site 645463003713 nucleotide binding site [chemical binding]; other site 645463003714 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645463003715 domain I; other site 645463003716 DNA binding groove [nucleotide binding] 645463003717 phosphate binding site [ion binding]; other site 645463003718 domain II; other site 645463003719 domain III; other site 645463003720 nucleotide binding site [chemical binding]; other site 645463003721 catalytic site [active] 645463003722 domain IV; other site 645463003723 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 645463003724 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 645463003725 CodY GAF-like domain; Region: CodY; pfam06018 645463003726 transcriptional repressor CodY; Validated; Region: PRK04158 645463003727 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 645463003728 recombination factor protein RarA; Reviewed; Region: PRK13342 645463003729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463003730 Walker A motif; other site 645463003731 ATP binding site [chemical binding]; other site 645463003732 Walker B motif; other site 645463003733 arginine finger; other site 645463003734 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 645463003735 Predicted acetyltransferase [General function prediction only]; Region: COG3393 645463003736 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 645463003737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463003738 Coenzyme A binding pocket [chemical binding]; other site 645463003739 Predicted transcriptional regulator [Transcription]; Region: COG1959 645463003740 Rrf2 family protein; Region: rrf2_super; TIGR00738 645463003741 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 645463003742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463003743 catalytic residue [active] 645463003744 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 645463003745 trimerization site [polypeptide binding]; other site 645463003746 active site 645463003747 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 645463003748 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 645463003749 Ligand Binding Site [chemical binding]; other site 645463003750 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 645463003751 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 645463003752 motif 1; other site 645463003753 active site 645463003754 motif 2; other site 645463003755 motif 3; other site 645463003756 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645463003757 DHHA1 domain; Region: DHHA1; pfam02272 645463003758 hypothetical protein; Provisional; Region: PRK05473 645463003759 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 645463003760 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 645463003761 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 645463003762 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 645463003763 metal binding site 2 [ion binding]; metal-binding site 645463003764 putative DNA binding helix; other site 645463003765 metal binding site 1 [ion binding]; metal-binding site 645463003766 dimer interface [polypeptide binding]; other site 645463003767 structural Zn2+ binding site [ion binding]; other site 645463003768 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 645463003769 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 645463003770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 645463003771 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 645463003772 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645463003773 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 645463003774 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 645463003775 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 645463003776 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645463003777 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463003778 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 645463003779 Peptidase family M50; Region: Peptidase_M50; pfam02163 645463003780 active site 645463003781 putative substrate binding region [chemical binding]; other site 645463003782 ScpA/B protein; Region: ScpA_ScpB; cl00598 645463003783 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 645463003784 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 645463003785 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 645463003786 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463003787 MarR family; Region: MarR_2; pfam12802 645463003788 multifunctional aminopeptidase A; Provisional; Region: PRK00913 645463003789 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 645463003790 interface (dimer of trimers) [polypeptide binding]; other site 645463003791 Substrate-binding/catalytic site; other site 645463003792 Zn-binding sites [ion binding]; other site 645463003793 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 645463003794 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 645463003795 homodimer interface [polypeptide binding]; other site 645463003796 metal binding site [ion binding]; metal-binding site 645463003797 NAD-dependent deacetylase; Provisional; Region: PRK00481 645463003798 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003799 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003800 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003801 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463003802 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 645463003803 DNA polymerase III PolC; Validated; Region: polC; PRK00448 645463003804 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 645463003805 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 645463003806 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 645463003807 generic binding surface II; other site 645463003808 generic binding surface I; other site 645463003809 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 645463003810 active site 645463003811 putative PHP Thumb interface [polypeptide binding]; other site 645463003812 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645463003813 active site 645463003814 catalytic site [active] 645463003815 substrate binding site [chemical binding]; other site 645463003816 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 645463003817 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 645463003818 Sm and related proteins; Region: Sm_like; cl00259 645463003819 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 645463003820 putative oligomer interface [polypeptide binding]; other site 645463003821 putative RNA binding site [nucleotide binding]; other site 645463003822 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 645463003823 NusA N-terminal domain; Region: NusA_N; pfam08529 645463003824 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 645463003825 RNA binding site [nucleotide binding]; other site 645463003826 homodimer interface [polypeptide binding]; other site 645463003827 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645463003828 G-X-X-G motif; other site 645463003829 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 645463003830 G-X-X-G motif; other site 645463003831 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 645463003832 putative RNA binding cleft [nucleotide binding]; other site 645463003833 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 645463003834 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645463003835 translation initiation factor IF-2; Region: IF-2; TIGR00487 645463003836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 645463003837 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 645463003838 G1 box; other site 645463003839 putative GEF interaction site [polypeptide binding]; other site 645463003840 GTP/Mg2+ binding site [chemical binding]; other site 645463003841 Switch I region; other site 645463003842 G2 box; other site 645463003843 G3 box; other site 645463003844 Switch II region; other site 645463003845 G4 box; other site 645463003846 G5 box; other site 645463003847 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 645463003848 Translation-initiation factor 2; Region: IF-2; pfam11987 645463003849 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 645463003850 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 645463003851 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 645463003852 DHH family; Region: DHH; pfam01368 645463003853 DHHA1 domain; Region: DHHA1; pfam02272 645463003854 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 645463003855 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 645463003856 RNA binding site [nucleotide binding]; other site 645463003857 active site 645463003858 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 645463003859 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 645463003860 active site 645463003861 Riboflavin kinase; Region: Flavokinase; pfam01687 645463003862 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 645463003863 16S/18S rRNA binding site [nucleotide binding]; other site 645463003864 S13e-L30e interaction site [polypeptide binding]; other site 645463003865 25S rRNA binding site [nucleotide binding]; other site 645463003866 EDD domain protein, DegV family; Region: DegV; TIGR00762 645463003867 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 645463003868 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 645463003869 RNase E interface [polypeptide binding]; other site 645463003870 trimer interface [polypeptide binding]; other site 645463003871 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 645463003872 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 645463003873 RNase E interface [polypeptide binding]; other site 645463003874 trimer interface [polypeptide binding]; other site 645463003875 active site 645463003876 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 645463003877 putative nucleic acid binding region [nucleotide binding]; other site 645463003878 G-X-X-G motif; other site 645463003879 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 645463003880 RNA binding site [nucleotide binding]; other site 645463003881 domain interface; other site 645463003882 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 645463003883 NodB motif; other site 645463003884 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645463003885 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 645463003886 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645463003887 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 645463003888 aspartate kinase I; Reviewed; Region: PRK08210 645463003889 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 645463003890 putative catalytic residues [active] 645463003891 putative nucleotide binding site [chemical binding]; other site 645463003892 putative aspartate binding site [chemical binding]; other site 645463003893 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 645463003894 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 645463003895 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 645463003896 active site 645463003897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463003898 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 645463003899 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463003900 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 645463003901 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 645463003902 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 645463003903 active site residue [active] 645463003904 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 645463003905 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645463003906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463003907 FeS/SAM binding site; other site 645463003908 TRAM domain; Region: TRAM; cl01282 645463003909 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 645463003910 recombinase A; Provisional; Region: recA; PRK09354 645463003911 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 645463003912 hexamer interface [polypeptide binding]; other site 645463003913 Walker A motif; other site 645463003914 ATP binding site [chemical binding]; other site 645463003915 Walker B motif; other site 645463003916 ribonuclease Y; Region: RNase_Y; TIGR03319 645463003917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645463003918 Zn2+ binding site [ion binding]; other site 645463003919 Mg2+ binding site [ion binding]; other site 645463003920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463003921 ATP binding site [chemical binding]; other site 645463003922 putative Mg++ binding site [ion binding]; other site 645463003923 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 645463003924 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 645463003925 Catalytic site [active] 645463003926 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 645463003927 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 645463003928 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463003929 active site 645463003930 Int/Topo IB signature motif; other site 645463003931 DNA binding site [nucleotide binding] 645463003932 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 645463003933 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 645463003934 tetramer interface [polypeptide binding]; other site 645463003935 active site 645463003936 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463003937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463003938 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463003939 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 645463003940 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463003941 active site turn [active] 645463003942 phosphorylation site [posttranslational modification] 645463003943 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463003944 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463003945 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463003946 putative active site [active] 645463003947 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645463003948 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 645463003949 NAD binding site [chemical binding]; other site 645463003950 sugar binding site [chemical binding]; other site 645463003951 divalent metal binding site [ion binding]; other site 645463003952 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463003953 dimer interface [polypeptide binding]; other site 645463003954 aspartate aminotransferase; Provisional; Region: PRK07568 645463003955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463003956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463003957 homodimer interface [polypeptide binding]; other site 645463003958 catalytic residue [active] 645463003959 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 645463003960 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 645463003961 nucleotide binding site/active site [active] 645463003962 HIT family signature motif; other site 645463003963 catalytic residue [active] 645463003964 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 645463003965 active site 645463003966 putative catalytic site [active] 645463003967 DNA binding site [nucleotide binding] 645463003968 putative phosphate binding site [ion binding]; other site 645463003969 metal binding site A [ion binding]; metal-binding site 645463003970 AP binding site [nucleotide binding]; other site 645463003971 metal binding site B [ion binding]; metal-binding site 645463003972 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 645463003973 active site 645463003974 substrate binding site [chemical binding]; other site 645463003975 catalytic site [active] 645463003976 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 645463003977 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 645463003978 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 645463003979 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 645463003980 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 645463003981 Predicted transcriptional regulators [Transcription]; Region: COG1695 645463003982 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 645463003983 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 645463003984 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 645463003985 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 645463003986 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 645463003987 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463003988 Walker A/P-loop; other site 645463003989 ATP binding site [chemical binding]; other site 645463003990 Q-loop/lid; other site 645463003991 ABC transporter signature motif; other site 645463003992 Walker B; other site 645463003993 D-loop; other site 645463003994 H-loop/switch region; other site 645463003995 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 645463003996 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 645463003997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463003998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463003999 dimer interface [polypeptide binding]; other site 645463004000 phosphorylation site [posttranslational modification] 645463004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463004002 ATP binding site [chemical binding]; other site 645463004003 Mg2+ binding site [ion binding]; other site 645463004004 G-X-G motif; other site 645463004005 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 645463004006 dimer interface [polypeptide binding]; other site 645463004007 pyridoxal binding site [chemical binding]; other site 645463004008 ATP binding site [chemical binding]; other site 645463004009 Putative amidase domain; Region: Amidase_6; pfam12671 645463004010 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645463004011 DNA-binding site [nucleotide binding]; DNA binding site 645463004012 RNA-binding motif; other site 645463004013 FOG: CBS domain [General function prediction only]; Region: COG0517 645463004014 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 645463004015 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 645463004016 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 645463004017 Domain of unknown function (DUF955); Region: DUF955; cl01076 645463004018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463004019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004020 non-specific DNA binding site [nucleotide binding]; other site 645463004021 salt bridge; other site 645463004022 sequence-specific DNA binding site [nucleotide binding]; other site 645463004023 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 645463004024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004025 non-specific DNA binding site [nucleotide binding]; other site 645463004026 salt bridge; other site 645463004027 sequence-specific DNA binding site [nucleotide binding]; other site 645463004028 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 645463004029 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 645463004030 Phage XkdN-like protein; Region: XkdN; pfam08890 645463004031 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 645463004032 Phage-related protein [Function unknown]; Region: COG5412 645463004033 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463004034 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 645463004035 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 645463004036 Baseplate J-like protein; Region: Baseplate_J; pfam04865 645463004037 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 645463004038 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 645463004039 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004040 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 645463004041 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004042 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004043 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 645463004044 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 645463004046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004047 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 645463004048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004049 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 645463004050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004051 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004052 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 645463004053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 645463004054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 645463004055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004056 non-specific DNA binding site [nucleotide binding]; other site 645463004057 salt bridge; other site 645463004058 sequence-specific DNA binding site [nucleotide binding]; other site 645463004059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004060 non-specific DNA binding site [nucleotide binding]; other site 645463004061 salt bridge; other site 645463004062 sequence-specific DNA binding site [nucleotide binding]; other site 645463004063 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463004064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004065 non-specific DNA binding site [nucleotide binding]; other site 645463004066 salt bridge; other site 645463004067 sequence-specific DNA binding site [nucleotide binding]; other site 645463004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463004069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463004070 putative substrate translocation pore; other site 645463004071 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 645463004072 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 645463004073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463004074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463004075 glycerol kinase; Provisional; Region: glpK; PRK00047 645463004076 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 645463004077 N- and C-terminal domain interface [polypeptide binding]; other site 645463004078 active site 645463004079 MgATP binding site [chemical binding]; other site 645463004080 catalytic site [active] 645463004081 metal binding site [ion binding]; metal-binding site 645463004082 glycerol binding site [chemical binding]; other site 645463004083 homotetramer interface [polypeptide binding]; other site 645463004084 homodimer interface [polypeptide binding]; other site 645463004085 FBP binding site [chemical binding]; other site 645463004086 protein IIAGlc interface [polypeptide binding]; other site 645463004087 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463004088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004089 DNA-binding site [nucleotide binding]; DNA binding site 645463004090 TrkA-C domain; Region: TrkA_C; pfam02080 645463004091 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 645463004092 putative active site [active] 645463004093 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 645463004094 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 645463004095 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 645463004096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004097 non-specific DNA binding site [nucleotide binding]; other site 645463004098 salt bridge; other site 645463004099 sequence-specific DNA binding site [nucleotide binding]; other site 645463004100 Cupin domain; Region: Cupin_2; pfam07883 645463004101 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 645463004102 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 645463004103 active site 645463004104 Protein of unknown function (DUF819); Region: DUF819; cl02317 645463004105 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 645463004106 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 645463004107 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 645463004108 homotrimer interaction site [polypeptide binding]; other site 645463004109 putative active site [active] 645463004110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645463004111 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645463004112 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645463004113 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 645463004114 Regulatory protein YrvL; Region: YrvL; pfam14184 645463004115 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 645463004116 SxDxEG motif; other site 645463004117 putative active site [active] 645463004118 putative metal binding site [ion binding]; other site 645463004119 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 645463004120 homodimer interaction site [polypeptide binding]; other site 645463004121 cofactor binding site; other site 645463004122 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463004123 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463004124 metal binding site [ion binding]; metal-binding site 645463004125 dimer interface [polypeptide binding]; other site 645463004126 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 645463004127 dimer interface [polypeptide binding]; other site 645463004128 catalytic triad [active] 645463004129 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 645463004130 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 645463004131 catalytic triad [active] 645463004132 conserved cis-peptide bond; other site 645463004133 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 645463004134 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 645463004135 active site 645463004136 catalytic site [active] 645463004137 metal binding site [ion binding]; metal-binding site 645463004138 dimer interface [polypeptide binding]; other site 645463004139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 645463004140 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 645463004141 acyl-activating enzyme (AAE) consensus motif; other site 645463004142 AMP binding site [chemical binding]; other site 645463004143 OPT oligopeptide transporter protein; Region: OPT; pfam03169 645463004144 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 645463004145 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645463004146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463004147 ABC transporter; Region: ABC_tran_2; pfam12848 645463004148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463004149 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 645463004150 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 645463004151 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645463004152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004153 DNA-binding site [nucleotide binding]; DNA binding site 645463004154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463004155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463004156 homodimer interface [polypeptide binding]; other site 645463004157 catalytic residue [active] 645463004158 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 645463004159 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 645463004160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645463004161 competence damage-inducible protein A; Provisional; Region: PRK00549 645463004162 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 645463004163 putative MPT binding site; other site 645463004164 Competence-damaged protein; Region: CinA; pfam02464 645463004165 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645463004166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463004167 active site 645463004168 motif I; other site 645463004169 motif II; other site 645463004170 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463004171 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 645463004172 PAS domain; Region: PAS_9; pfam13426 645463004173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463004174 putative active site [active] 645463004175 heme pocket [chemical binding]; other site 645463004176 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 645463004177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463004178 Walker A motif; other site 645463004179 ATP binding site [chemical binding]; other site 645463004180 Walker B motif; other site 645463004181 arginine finger; other site 645463004182 EamA-like transporter family; Region: EamA; pfam00892 645463004183 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 645463004184 EamA-like transporter family; Region: EamA; pfam00892 645463004185 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 645463004186 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 645463004187 Protein of unknown function, DUF606; Region: DUF606; cl01273 645463004188 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 645463004189 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 645463004190 Ligand Binding Site [chemical binding]; other site 645463004191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463004192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463004193 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 645463004194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463004195 PAS fold; Region: PAS_3; pfam08447 645463004196 putative active site [active] 645463004197 heme pocket [chemical binding]; other site 645463004198 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 645463004199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004200 metal binding site [ion binding]; metal-binding site 645463004201 active site 645463004202 I-site; other site 645463004203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004204 metal binding site [ion binding]; metal-binding site 645463004205 active site 645463004206 I-site; other site 645463004207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004208 metal binding site [ion binding]; metal-binding site 645463004209 active site 645463004210 I-site; other site 645463004211 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463004212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463004213 PAS fold; Region: PAS_3; pfam08447 645463004214 putative active site [active] 645463004215 heme pocket [chemical binding]; other site 645463004216 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463004217 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 645463004218 DNA binding residues [nucleotide binding] 645463004219 dimer interface [polypeptide binding]; other site 645463004220 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463004221 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 645463004222 MgtC family; Region: MgtC; pfam02308 645463004223 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 645463004224 catalytic triad [active] 645463004225 conserved cis-peptide bond; other site 645463004226 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463004227 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 645463004228 Predicted acetyltransferase [General function prediction only]; Region: COG3393 645463004229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463004230 Putative lysophospholipase; Region: Hydrolase_4; cl19140 645463004231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463004232 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463004233 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 645463004234 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 645463004235 NodB motif; other site 645463004236 active site 645463004237 catalytic site [active] 645463004238 Cd binding site [ion binding]; other site 645463004239 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 645463004240 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645463004241 active site 645463004242 catalytic site [active] 645463004243 substrate binding site [chemical binding]; other site 645463004244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645463004245 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 645463004246 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 645463004247 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 645463004248 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_like; cd09277 645463004249 RNA/DNA hybrid binding site [nucleotide binding]; other site 645463004250 active site 645463004251 peroxiredoxin; Provisional; Region: PRK13189 645463004252 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 645463004253 dimer interface [polypeptide binding]; other site 645463004254 decamer (pentamer of dimers) interface [polypeptide binding]; other site 645463004255 catalytic triad [active] 645463004256 Glyco_18 domain; Region: Glyco_18; smart00636 645463004257 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 645463004258 active site 645463004259 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645463004260 VanW like protein; Region: VanW; pfam04294 645463004261 G5 domain; Region: G5; pfam07501 645463004262 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 645463004263 hypothetical protein; Provisional; Region: PHA02938 645463004264 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463004265 IncA protein; Region: IncA; pfam04156 645463004266 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 645463004267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463004268 binding surface 645463004269 TPR motif; other site 645463004270 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 645463004271 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 645463004272 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463004273 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463004274 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645463004275 MORN repeat; Region: MORN; cl14787 645463004276 MORN repeat; Region: MORN; cl14787 645463004277 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 645463004278 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 645463004279 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645463004280 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645463004281 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 645463004282 NodB motif; other site 645463004283 active site 645463004284 catalytic site [active] 645463004285 metal binding site [ion binding]; metal-binding site 645463004286 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 645463004287 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 645463004288 glutamine binding [chemical binding]; other site 645463004289 catalytic triad [active] 645463004290 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 645463004291 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 645463004292 chorismate binding enzyme; Region: Chorismate_bind; cl10555 645463004293 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 645463004294 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 645463004295 homodimer interface [polypeptide binding]; other site 645463004296 substrate-cofactor binding pocket; other site 645463004297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463004298 catalytic residue [active] 645463004299 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 645463004300 active site 645463004301 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 645463004302 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 645463004303 substrate binding pocket [chemical binding]; other site 645463004304 dimer interface [polypeptide binding]; other site 645463004305 inhibitor binding site; inhibition site 645463004306 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 645463004307 homooctamer interface [polypeptide binding]; other site 645463004308 active site 645463004309 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 645463004310 catalytic center binding site [active] 645463004311 ATP binding site [chemical binding]; other site 645463004312 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 645463004313 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 645463004314 DNA primase; Validated; Region: dnaG; PRK05667 645463004315 CHC2 zinc finger; Region: zf-CHC2; pfam01807 645463004316 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 645463004317 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 645463004318 active site 645463004319 metal binding site [ion binding]; metal-binding site 645463004320 interdomain interaction site; other site 645463004321 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 645463004322 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 645463004323 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 645463004324 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 645463004325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463004326 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463004327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463004328 DNA binding residues [nucleotide binding] 645463004329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463004330 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 645463004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 645463004332 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 645463004333 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 645463004334 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 645463004335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645463004336 Zn2+ binding site [ion binding]; other site 645463004337 Mg2+ binding site [ion binding]; other site 645463004338 Protein of unknown function (DUF1648); Region: DUF1648; cl19856 645463004339 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463004340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004341 DNA-binding site [nucleotide binding]; DNA binding site 645463004342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463004343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463004344 active site 645463004345 phosphorylation site [posttranslational modification] 645463004346 intermolecular recognition site; other site 645463004347 dimerization interface [polypeptide binding]; other site 645463004348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463004349 DNA binding site [nucleotide binding] 645463004350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463004351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463004352 dimer interface [polypeptide binding]; other site 645463004353 phosphorylation site [posttranslational modification] 645463004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463004355 ATP binding site [chemical binding]; other site 645463004356 Mg2+ binding site [ion binding]; other site 645463004357 G-X-G motif; other site 645463004358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463004359 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463004360 Walker A/P-loop; other site 645463004361 ATP binding site [chemical binding]; other site 645463004362 Q-loop/lid; other site 645463004363 ABC transporter signature motif; other site 645463004364 Walker B; other site 645463004365 D-loop; other site 645463004366 H-loop/switch region; other site 645463004367 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463004368 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463004369 FtsX-like permease family; Region: FtsX; pfam02687 645463004370 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463004371 FtsX-like permease family; Region: FtsX; pfam02687 645463004372 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 645463004373 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463004374 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463004375 Beta-lactamase; Region: Beta-lactamase; pfam00144 645463004376 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004377 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004378 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004379 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645463004380 active site residue [active] 645463004381 Predicted membrane protein [Function unknown]; Region: COG1511 645463004382 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 645463004383 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 645463004384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463004385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463004386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463004387 Walker A/P-loop; other site 645463004388 ATP binding site [chemical binding]; other site 645463004389 Q-loop/lid; other site 645463004390 ABC transporter signature motif; other site 645463004391 Walker B; other site 645463004392 D-loop; other site 645463004393 H-loop/switch region; other site 645463004394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463004395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463004396 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645463004397 Walker A/P-loop; other site 645463004398 ATP binding site [chemical binding]; other site 645463004399 Q-loop/lid; other site 645463004400 ABC transporter signature motif; other site 645463004401 Walker B; other site 645463004402 D-loop; other site 645463004403 H-loop/switch region; other site 645463004404 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 645463004405 iron binding site [ion binding]; other site 645463004406 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 645463004407 Rubrerythrin [Energy production and conversion]; Region: COG1592 645463004408 diiron binding motif [ion binding]; other site 645463004409 CAAX protease self-immunity; Region: Abi; pfam02517 645463004410 Dienelactone hydrolase family; Region: DLH; pfam01738 645463004411 FeoA domain; Region: FeoA; pfam04023 645463004412 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 645463004413 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 645463004414 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 645463004415 G1 box; other site 645463004416 GTP/Mg2+ binding site [chemical binding]; other site 645463004417 Switch I region; other site 645463004418 G2 box; other site 645463004419 G3 box; other site 645463004420 Switch II region; other site 645463004421 G4 box; other site 645463004422 G5 box; other site 645463004423 Nucleoside recognition; Region: Gate; pfam07670 645463004424 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 645463004425 Nucleoside recognition; Region: Gate; pfam07670 645463004426 Virus attachment protein p12 family; Region: P12; pfam12669 645463004427 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 645463004428 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645463004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463004430 dimer interface [polypeptide binding]; other site 645463004431 conserved gate region; other site 645463004432 putative PBP binding loops; other site 645463004433 ABC-ATPase subunit interface; other site 645463004434 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645463004435 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 645463004436 Walker A/P-loop; other site 645463004437 ATP binding site [chemical binding]; other site 645463004438 Q-loop/lid; other site 645463004439 ABC transporter signature motif; other site 645463004440 Walker B; other site 645463004441 D-loop; other site 645463004442 H-loop/switch region; other site 645463004443 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 645463004444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463004445 substrate binding pocket [chemical binding]; other site 645463004446 membrane-bound complex binding site; other site 645463004447 hinge residues; other site 645463004448 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 645463004449 Predicted transcriptional regulator [Transcription]; Region: COG2378 645463004450 HTH domain; Region: HTH_11; pfam08279 645463004451 WYL domain; Region: WYL; pfam13280 645463004452 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 645463004453 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 645463004454 Walker A/P-loop; other site 645463004455 ATP binding site [chemical binding]; other site 645463004456 Q-loop/lid; other site 645463004457 ABC transporter signature motif; other site 645463004458 Walker B; other site 645463004459 D-loop; other site 645463004460 H-loop/switch region; other site 645463004461 NIL domain; Region: NIL; pfam09383 645463004462 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 645463004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463004464 dimer interface [polypeptide binding]; other site 645463004465 conserved gate region; other site 645463004466 putative PBP binding loops; other site 645463004467 ABC-ATPase subunit interface; other site 645463004468 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 645463004469 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 645463004470 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645463004471 PAS domain; Region: PAS_8; pfam13188 645463004472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463004473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463004474 dimer interface [polypeptide binding]; other site 645463004475 phosphorylation site [posttranslational modification] 645463004476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463004477 ATP binding site [chemical binding]; other site 645463004478 Mg2+ binding site [ion binding]; other site 645463004479 G-X-G motif; other site 645463004480 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 645463004481 active site 645463004482 DNA binding site [nucleotide binding] 645463004483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463004484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004485 non-specific DNA binding site [nucleotide binding]; other site 645463004486 salt bridge; other site 645463004487 sequence-specific DNA binding site [nucleotide binding]; other site 645463004488 Cupin domain; Region: Cupin_2; pfam07883 645463004489 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 645463004490 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 645463004491 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 645463004492 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 645463004493 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 645463004494 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 645463004495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463004496 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463004497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463004498 DNA binding residues [nucleotide binding] 645463004499 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 645463004500 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 645463004501 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 645463004502 intersubunit interface [polypeptide binding]; other site 645463004503 active site 645463004504 catalytic residue [active] 645463004505 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463004506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004507 DNA-binding site [nucleotide binding]; DNA binding site 645463004508 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463004509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463004510 Walker A/P-loop; other site 645463004511 ATP binding site [chemical binding]; other site 645463004512 Q-loop/lid; other site 645463004513 ABC transporter signature motif; other site 645463004514 Walker B; other site 645463004515 D-loop; other site 645463004516 H-loop/switch region; other site 645463004517 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463004518 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463004519 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645463004520 catalytic residues [active] 645463004521 4Fe-4S binding domain; Region: Fer4_5; pfam12801 645463004522 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 645463004523 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463004524 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 645463004525 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 645463004526 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 645463004527 Pantoate-beta-alanine ligase; Region: PanC; cd00560 645463004528 active site 645463004529 ATP-binding site [chemical binding]; other site 645463004530 pantoate-binding site; other site 645463004531 HXXH motif; other site 645463004532 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 645463004533 oligomerization interface [polypeptide binding]; other site 645463004534 active site 645463004535 metal binding site [ion binding]; metal-binding site 645463004536 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 645463004537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463004538 PAS fold; Region: PAS_3; pfam08447 645463004539 putative active site [active] 645463004540 heme pocket [chemical binding]; other site 645463004541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004542 metal binding site [ion binding]; metal-binding site 645463004543 active site 645463004544 I-site; other site 645463004545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463004546 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 645463004547 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463004548 DNA binding residues [nucleotide binding] 645463004549 dimer interface [polypeptide binding]; other site 645463004550 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 645463004551 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 645463004552 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 645463004553 G1 box; other site 645463004554 GTP/Mg2+ binding site [chemical binding]; other site 645463004555 Switch I region; other site 645463004556 G2 box; other site 645463004557 G3 box; other site 645463004558 Switch II region; other site 645463004559 G4 box; other site 645463004560 G5 box; other site 645463004561 Nucleoside recognition; Region: Gate; pfam07670 645463004562 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 645463004563 Nucleoside recognition; Region: Gate; pfam07670 645463004564 FeoA domain; Region: FeoA; cl00838 645463004565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463004566 Coenzyme A binding pocket [chemical binding]; other site 645463004567 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 645463004568 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 645463004569 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 645463004570 active site 645463004571 HIGH motif; other site 645463004572 dimer interface [polypeptide binding]; other site 645463004573 KMSKS motif; other site 645463004574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463004575 RNA binding surface [nucleotide binding]; other site 645463004576 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 645463004577 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 645463004578 NodB motif; other site 645463004579 active site 645463004580 catalytic site [active] 645463004581 Zn binding site [ion binding]; other site 645463004582 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645463004583 EamA-like transporter family; Region: EamA; pfam00892 645463004584 EamA-like transporter family; Region: EamA; pfam00892 645463004585 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 645463004586 Rubredoxin; Region: Rubredoxin; pfam00301 645463004587 iron binding site [ion binding]; other site 645463004588 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 645463004589 Rubrerythrin [Energy production and conversion]; Region: COG1592 645463004590 diiron binding motif [ion binding]; other site 645463004591 Domain of unknown function (DUF362); Region: DUF362; cl19822 645463004592 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 645463004593 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 645463004594 dihydroorotase; Validated; Region: pyrC; PRK09357 645463004595 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463004596 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 645463004597 active site 645463004598 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463004599 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463004600 FtsX-like permease family; Region: FtsX; pfam02687 645463004601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463004602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463004603 Walker A/P-loop; other site 645463004604 ATP binding site [chemical binding]; other site 645463004605 Q-loop/lid; other site 645463004606 ABC transporter signature motif; other site 645463004607 Walker B; other site 645463004608 D-loop; other site 645463004609 H-loop/switch region; other site 645463004610 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 645463004611 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 645463004612 HlyD family secretion protein; Region: HlyD_3; pfam13437 645463004613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463004614 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 645463004615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463004616 ATP binding site [chemical binding]; other site 645463004617 Mg2+ binding site [ion binding]; other site 645463004618 G-X-G motif; other site 645463004619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463004620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463004621 active site 645463004622 phosphorylation site [posttranslational modification] 645463004623 intermolecular recognition site; other site 645463004624 dimerization interface [polypeptide binding]; other site 645463004625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463004626 DNA binding site [nucleotide binding] 645463004627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463004628 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463004629 Walker A/P-loop; other site 645463004630 ATP binding site [chemical binding]; other site 645463004631 Q-loop/lid; other site 645463004632 ABC transporter signature motif; other site 645463004633 Walker B; other site 645463004634 D-loop; other site 645463004635 H-loop/switch region; other site 645463004636 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463004637 FtsX-like permease family; Region: FtsX; pfam02687 645463004638 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 645463004639 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 645463004640 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 645463004641 active site residue [active] 645463004642 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 645463004643 active site residue [active] 645463004644 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 645463004645 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 645463004646 FAD binding pocket [chemical binding]; other site 645463004647 FAD binding motif [chemical binding]; other site 645463004648 phosphate binding motif [ion binding]; other site 645463004649 beta-alpha-beta structure motif; other site 645463004650 NAD binding pocket [chemical binding]; other site 645463004651 Iron coordination center [ion binding]; other site 645463004652 putative oxidoreductase; Provisional; Region: PRK12831 645463004653 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 645463004654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463004655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463004656 Cache domain; Region: Cache_1; pfam02743 645463004657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004658 metal binding site [ion binding]; metal-binding site 645463004659 active site 645463004660 I-site; other site 645463004661 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463004662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463004663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463004664 Walker A/P-loop; other site 645463004665 ATP binding site [chemical binding]; other site 645463004666 Q-loop/lid; other site 645463004667 ABC transporter signature motif; other site 645463004668 Walker B; other site 645463004669 D-loop; other site 645463004670 H-loop/switch region; other site 645463004671 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463004672 FtsX-like permease family; Region: FtsX; pfam02687 645463004673 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 645463004674 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463004675 Fic family protein [Function unknown]; Region: COG3177 645463004676 Fic/DOC family; Region: Fic; pfam02661 645463004677 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 645463004678 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 645463004679 Haemolysin-III related; Region: HlyIII; cl03831 645463004680 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 645463004681 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 645463004682 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 645463004683 motif 1; other site 645463004684 dimer interface [polypeptide binding]; other site 645463004685 active site 645463004686 motif 2; other site 645463004687 motif 3; other site 645463004688 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 645463004689 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 645463004690 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 645463004691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463004692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463004693 homodimer interface [polypeptide binding]; other site 645463004694 catalytic residue [active] 645463004695 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 645463004696 putative active site pocket [active] 645463004697 4-fold oligomerization interface [polypeptide binding]; other site 645463004698 metal binding residues [ion binding]; metal-binding site 645463004699 3-fold/trimer interface [polypeptide binding]; other site 645463004700 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 645463004701 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 645463004702 putative active site [active] 645463004703 oxyanion strand; other site 645463004704 catalytic triad [active] 645463004705 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 645463004706 catalytic residues [active] 645463004707 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 645463004708 substrate binding site [chemical binding]; other site 645463004709 glutamase interaction surface [polypeptide binding]; other site 645463004710 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 645463004711 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 645463004712 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 645463004713 metal binding site [ion binding]; metal-binding site 645463004714 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 645463004715 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463004716 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645463004717 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 645463004718 NodB motif; other site 645463004719 active site 645463004720 catalytic site [active] 645463004721 Zn binding site [ion binding]; other site 645463004722 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 645463004723 SurA N-terminal domain; Region: SurA_N_3; cl07813 645463004724 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 645463004725 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 645463004726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463004727 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463004728 DNA binding residues [nucleotide binding] 645463004729 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645463004730 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645463004731 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645463004732 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645463004733 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 645463004734 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 645463004735 XdhC Rossmann domain; Region: XdhC_C; pfam13478 645463004736 Protein of unknown function DUF45; Region: DUF45; pfam01863 645463004737 ACT domain; Region: ACT_5; pfam13710 645463004738 ketol-acid reductoisomerase; Provisional; Region: PRK05479 645463004739 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 645463004740 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 645463004741 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 645463004742 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 645463004743 PYR/PP interface [polypeptide binding]; other site 645463004744 dimer interface [polypeptide binding]; other site 645463004745 TPP binding site [chemical binding]; other site 645463004746 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 645463004747 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 645463004748 TPP-binding site [chemical binding]; other site 645463004749 dimer interface [polypeptide binding]; other site 645463004750 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 645463004751 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645463004752 Int/Topo IB signature motif; other site 645463004753 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 645463004754 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 645463004755 HipA-like C-terminal domain; Region: HipA_C; pfam07804 645463004756 putative catalytic residues [active] 645463004757 putative catalytic loop [active] 645463004758 Domain of unknown function (DUF955); Region: DUF955; pfam06114 645463004759 Prophage antirepressor [Transcription]; Region: COG3617 645463004760 BRO family, N-terminal domain; Region: Bro-N; smart01040 645463004761 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 645463004762 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 645463004763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463004764 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 645463004765 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 645463004766 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 645463004767 active site 645463004768 DNA binding site [nucleotide binding] 645463004769 catalytic site [active] 645463004770 Virulence-associated protein E; Region: VirE; pfam05272 645463004771 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 645463004772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463004773 ATP binding site [chemical binding]; other site 645463004774 putative Mg++ binding site [ion binding]; other site 645463004775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463004776 nucleotide binding region [chemical binding]; other site 645463004777 ATP-binding site [chemical binding]; other site 645463004778 DNA binding residues [nucleotide binding] 645463004779 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 645463004780 BRO family, N-terminal domain; Region: Bro-N; smart01040 645463004781 Uncharacterized conserved protein [Function unknown]; Region: COG5484 645463004782 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463004783 Phage terminase large subunit; Region: Terminase_3; cl12054 645463004784 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 645463004785 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 645463004786 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 645463004787 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 645463004788 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 645463004789 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 645463004790 Phage XkdN-like protein; Region: XkdN; pfam08890 645463004791 BRO family, N-terminal domain; Region: Bro-N; cl10591 645463004792 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 645463004793 Short C-terminal domain; Region: SHOCT; pfam09851 645463004794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 645463004795 Phage-related minor tail protein [Function unknown]; Region: COG5281 645463004796 tape measure domain; Region: tape_meas_nterm; TIGR02675 645463004797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645463004798 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645463004799 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463004800 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 645463004801 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 645463004802 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 645463004803 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 645463004804 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 645463004805 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 645463004806 Viral coat protein; Region: Flexi_CP; pfam00286 645463004807 Abi-like protein; Region: Abi_2; pfam07751 645463004808 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463004809 active site 645463004810 metal binding site [ion binding]; metal-binding site 645463004811 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 645463004812 Leucine-rich repeats; other site 645463004813 Substrate binding site [chemical binding]; other site 645463004814 Leucine rich repeat; Region: LRR_8; pfam13855 645463004815 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004816 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004817 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463004818 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 645463004819 Uncharacterized conserved protein [Function unknown]; Region: COG1633 645463004820 dimanganese center [ion binding]; other site 645463004821 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 645463004822 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 645463004823 catalytic residues [active] 645463004824 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463004825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463004826 Probable transposase; Region: OrfB_IS605; pfam01385 645463004827 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463004828 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463004829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463004830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463004831 non-specific DNA binding site [nucleotide binding]; other site 645463004832 salt bridge; other site 645463004833 sequence-specific DNA binding site [nucleotide binding]; other site 645463004834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645463004835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 645463004836 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645463004837 G5 domain; Region: G5; pfam07501 645463004838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 645463004839 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 645463004840 active site 645463004841 catalytic triad [active] 645463004842 oxyanion hole [active] 645463004843 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 645463004844 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 645463004845 active site 645463004846 substrate binding site [chemical binding]; other site 645463004847 metal binding site [ion binding]; metal-binding site 645463004848 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 645463004849 PAS fold; Region: PAS_4; pfam08448 645463004850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463004851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463004852 dimer interface [polypeptide binding]; other site 645463004853 phosphorylation site [posttranslational modification] 645463004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463004855 ATP binding site [chemical binding]; other site 645463004856 Mg2+ binding site [ion binding]; other site 645463004857 G-X-G motif; other site 645463004858 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 645463004859 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 645463004860 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 645463004861 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 645463004862 histidinol dehydrogenase; Region: hisD; TIGR00069 645463004863 NAD binding site [chemical binding]; other site 645463004864 dimerization interface [polypeptide binding]; other site 645463004865 product binding site; other site 645463004866 substrate binding site [chemical binding]; other site 645463004867 zinc binding site [ion binding]; other site 645463004868 catalytic residues [active] 645463004869 Putative lysophospholipase; Region: Hydrolase_4; cl19140 645463004870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463004871 Mor transcription activator family; Region: Mor; cl02360 645463004872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463004873 nucleotide binding site [chemical binding]; other site 645463004874 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463004875 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463004876 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463004877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463004878 nucleotide binding site [chemical binding]; other site 645463004879 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 645463004880 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 645463004881 Walker A/P-loop; other site 645463004882 ATP binding site [chemical binding]; other site 645463004883 Q-loop/lid; other site 645463004884 ABC transporter signature motif; other site 645463004885 Walker B; other site 645463004886 D-loop; other site 645463004887 H-loop/switch region; other site 645463004888 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 645463004889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 645463004890 TM-ABC transporter signature motif; other site 645463004891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 645463004892 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 645463004893 ligand binding site [chemical binding]; other site 645463004894 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463004895 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463004896 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 645463004897 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 645463004898 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463004899 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 645463004900 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 645463004901 cysteine synthase; Region: PLN02565 645463004902 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645463004903 dimer interface [polypeptide binding]; other site 645463004904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463004905 catalytic residue [active] 645463004906 serine O-acetyltransferase; Region: cysE; TIGR01172 645463004907 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 645463004908 trimer interface [polypeptide binding]; other site 645463004909 active site 645463004910 substrate binding site [chemical binding]; other site 645463004911 CoA binding site [chemical binding]; other site 645463004912 methionine aminopeptidase; Provisional; Region: PRK12318 645463004913 SEC-C motif; Region: SEC-C; pfam02810 645463004914 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 645463004915 active site 645463004916 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 645463004917 GIY-YIG motif/motif A; other site 645463004918 putative active site [active] 645463004919 putative metal binding site [ion binding]; other site 645463004920 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 645463004921 dimer interface [polypeptide binding]; other site 645463004922 substrate binding site [chemical binding]; other site 645463004923 ATP binding site [chemical binding]; other site 645463004924 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 645463004925 substrate binding site [chemical binding]; other site 645463004926 multimerization interface [polypeptide binding]; other site 645463004927 ATP binding site [chemical binding]; other site 645463004928 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 645463004929 thiamine phosphate binding site [chemical binding]; other site 645463004930 active site 645463004931 pyrophosphate binding site [ion binding]; other site 645463004932 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463004933 active site 645463004934 P-loop; other site 645463004935 phosphorylation site [posttranslational modification] 645463004936 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645463004937 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 645463004938 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463004940 Walker A/P-loop; other site 645463004941 ATP binding site [chemical binding]; other site 645463004942 Q-loop/lid; other site 645463004943 ABC transporter signature motif; other site 645463004944 Walker B; other site 645463004945 D-loop; other site 645463004946 H-loop/switch region; other site 645463004947 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463004948 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463004949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004950 DNA-binding site [nucleotide binding]; DNA binding site 645463004951 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645463004952 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463004953 Walker A/P-loop; other site 645463004954 ATP binding site [chemical binding]; other site 645463004955 Q-loop/lid; other site 645463004956 ABC transporter signature motif; other site 645463004957 Walker B; other site 645463004958 D-loop; other site 645463004959 H-loop/switch region; other site 645463004960 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 645463004961 Amidohydrolase; Region: Amidohydro_5; pfam13594 645463004962 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 645463004963 active site 645463004964 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 645463004965 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645463004966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463004967 Walker A/P-loop; other site 645463004968 ATP binding site [chemical binding]; other site 645463004969 Q-loop/lid; other site 645463004970 ABC transporter signature motif; other site 645463004971 Walker B; other site 645463004972 D-loop; other site 645463004973 H-loop/switch region; other site 645463004974 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 645463004975 Acyltransferase family; Region: Acyl_transf_3; cl19154 645463004976 CAAX protease self-immunity; Region: Abi; pfam02517 645463004977 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463004978 metal binding site [ion binding]; metal-binding site 645463004979 active site 645463004980 I-site; other site 645463004981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463004982 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463004983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463004984 DNA-binding site [nucleotide binding]; DNA binding site 645463004985 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645463004986 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463004987 Walker A/P-loop; other site 645463004988 ATP binding site [chemical binding]; other site 645463004989 Q-loop/lid; other site 645463004990 ABC transporter signature motif; other site 645463004991 Walker B; other site 645463004992 D-loop; other site 645463004993 H-loop/switch region; other site 645463004994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463004995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463004996 putative substrate translocation pore; other site 645463004997 Mechanosensitive ion channel; Region: MS_channel; pfam00924 645463004998 Predicted membrane protein [Function unknown]; Region: COG3212 645463004999 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645463005000 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645463005001 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 645463005002 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463005003 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 645463005004 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 645463005005 iron binding site [ion binding]; other site 645463005006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 645463005007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463005008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005010 active site 645463005011 phosphorylation site [posttranslational modification] 645463005012 intermolecular recognition site; other site 645463005013 dimerization interface [polypeptide binding]; other site 645463005014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005015 DNA binding site [nucleotide binding] 645463005016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005018 dimer interface [polypeptide binding]; other site 645463005019 phosphorylation site [posttranslational modification] 645463005020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005021 ATP binding site [chemical binding]; other site 645463005022 Mg2+ binding site [ion binding]; other site 645463005023 G-X-G motif; other site 645463005024 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 645463005025 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 645463005026 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 645463005027 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 645463005028 Acyltransferase family; Region: Acyl_transf_3; pfam01757 645463005029 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 645463005030 alanine racemase; Reviewed; Region: alr; PRK00053 645463005031 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, VanT and similar proteins; Region: PLPDE_III_VanT; cd06825 645463005032 active site 645463005033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463005034 dimer interface [polypeptide binding]; other site 645463005035 substrate binding site [chemical binding]; other site 645463005036 catalytic residues [active] 645463005037 Uncharacterized conserved protein [Function unknown]; Region: COG0398 645463005038 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 645463005039 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 645463005040 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 645463005041 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 645463005042 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 645463005043 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 645463005044 active site 645463005045 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 645463005046 Ligand Binding Site [chemical binding]; other site 645463005047 Molecular Tunnel; other site 645463005048 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 645463005049 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 645463005050 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645463005051 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005052 putative metal binding site [ion binding]; other site 645463005053 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005054 putative metal binding site [ion binding]; other site 645463005055 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005056 putative metal binding site [ion binding]; other site 645463005057 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645463005058 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645463005059 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463005060 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 645463005061 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645463005062 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645463005063 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 645463005064 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 645463005065 C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617 645463005066 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463005067 active site 645463005068 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 645463005069 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 645463005070 PELOTA RNA binding domain; Region: PELOTA_1; pfam15608 645463005071 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645463005072 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463005073 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463005074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005075 non-specific DNA binding site [nucleotide binding]; other site 645463005076 salt bridge; other site 645463005077 sequence-specific DNA binding site [nucleotide binding]; other site 645463005078 Cupin domain; Region: Cupin_2; pfam07883 645463005079 Predicted integral membrane protein [Function unknown]; Region: COG5505 645463005080 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 645463005081 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 645463005082 active site 645463005083 dimer interface [polypeptide binding]; other site 645463005084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645463005085 ABC-ATPase subunit interface; other site 645463005086 dimer interface [polypeptide binding]; other site 645463005087 putative PBP binding regions; other site 645463005088 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645463005089 ABC-ATPase subunit interface; other site 645463005090 dimer interface [polypeptide binding]; other site 645463005091 putative PBP binding regions; other site 645463005092 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 645463005093 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645463005094 Walker A/P-loop; other site 645463005095 ATP binding site [chemical binding]; other site 645463005096 Q-loop/lid; other site 645463005097 ABC transporter signature motif; other site 645463005098 Walker B; other site 645463005099 D-loop; other site 645463005100 H-loop/switch region; other site 645463005101 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645463005102 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 645463005103 putative ligand binding residues [chemical binding]; other site 645463005104 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 645463005105 nucleotidyl binding site; other site 645463005106 metal binding site [ion binding]; metal-binding site 645463005107 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463005108 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005109 putative metal binding site [ion binding]; other site 645463005110 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 645463005111 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 645463005112 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 645463005113 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 645463005114 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 645463005115 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 645463005116 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 645463005117 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 645463005118 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 645463005119 tetramer interface [polypeptide binding]; other site 645463005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463005121 catalytic residue [active] 645463005122 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 645463005123 tetramer interface [polypeptide binding]; other site 645463005124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463005125 catalytic residue [active] 645463005126 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645463005127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463005128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463005129 motif II; other site 645463005130 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645463005131 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 645463005132 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 645463005133 Protein of unknown function; Region: DUF3658; pfam12395 645463005134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463005135 guanine deaminase; Region: guan_deamin; TIGR02967 645463005136 active site 645463005137 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463005138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005139 non-specific DNA binding site [nucleotide binding]; other site 645463005140 salt bridge; other site 645463005141 sequence-specific DNA binding site [nucleotide binding]; other site 645463005142 Cupin domain; Region: Cupin_2; cl17218 645463005143 cysteine synthase; Region: PLN02565 645463005144 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 645463005145 dimer interface [polypeptide binding]; other site 645463005146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463005147 catalytic residue [active] 645463005148 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 645463005149 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 645463005150 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 645463005151 putative active site [active] 645463005152 catalytic site [active] 645463005153 putative metal binding site [ion binding]; other site 645463005154 maltose O-acetyltransferase; Provisional; Region: PRK10092 645463005155 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 645463005156 active site 645463005157 substrate binding site [chemical binding]; other site 645463005158 trimer interface [polypeptide binding]; other site 645463005159 CoA binding site [chemical binding]; other site 645463005160 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463005161 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 645463005162 Walker A/P-loop; other site 645463005163 ATP binding site [chemical binding]; other site 645463005164 Q-loop/lid; other site 645463005165 ABC transporter signature motif; other site 645463005166 Walker B; other site 645463005167 D-loop; other site 645463005168 H-loop/switch region; other site 645463005169 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463005170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005172 active site 645463005173 phosphorylation site [posttranslational modification] 645463005174 intermolecular recognition site; other site 645463005175 dimerization interface [polypeptide binding]; other site 645463005176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005177 DNA binding site [nucleotide binding] 645463005178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005179 HAMP domain; Region: HAMP; pfam00672 645463005180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005181 dimer interface [polypeptide binding]; other site 645463005182 phosphorylation site [posttranslational modification] 645463005183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005184 ATP binding site [chemical binding]; other site 645463005185 Mg2+ binding site [ion binding]; other site 645463005186 G-X-G motif; other site 645463005187 TraX protein; Region: TraX; cl05434 645463005188 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463005189 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463005190 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 645463005191 putative substrate binding pocket [chemical binding]; other site 645463005192 AC domain interface; other site 645463005193 catalytic triad [active] 645463005194 AB domain interface; other site 645463005195 interchain disulfide; other site 645463005196 Predicted membrane protein [Function unknown]; Region: COG3817 645463005197 Protein of unknown function (DUF979); Region: DUF979; pfam06166 645463005198 Protein of unknown function (DUF969); Region: DUF969; pfam06149 645463005199 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 645463005200 FMN-binding domain; Region: FMN_bind; cl01081 645463005201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463005202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463005203 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 645463005204 active site 645463005205 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 645463005206 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463005207 A new structural DNA glycosylase; Region: AlkD_like; cd06561 645463005208 active site 645463005209 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 645463005210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005212 active site 645463005213 phosphorylation site [posttranslational modification] 645463005214 intermolecular recognition site; other site 645463005215 dimerization interface [polypeptide binding]; other site 645463005216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005217 DNA binding site [nucleotide binding] 645463005218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005220 dimer interface [polypeptide binding]; other site 645463005221 phosphorylation site [posttranslational modification] 645463005222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005223 ATP binding site [chemical binding]; other site 645463005224 Mg2+ binding site [ion binding]; other site 645463005225 G-X-G motif; other site 645463005226 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645463005227 catalytic residues [active] 645463005228 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 645463005229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463005230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463005231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463005232 dimerization interface [polypeptide binding]; other site 645463005233 putative DNA binding site [nucleotide binding]; other site 645463005234 putative Zn2+ binding site [ion binding]; other site 645463005235 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 645463005236 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 645463005237 Citrate transporter; Region: CitMHS; pfam03600 645463005238 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 645463005239 transmembrane helices; other site 645463005240 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645463005241 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 645463005242 homopentamer interface [polypeptide binding]; other site 645463005243 active site 645463005244 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 645463005245 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 645463005246 dimerization interface [polypeptide binding]; other site 645463005247 active site 645463005248 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 645463005249 Lumazine binding domain; Region: Lum_binding; pfam00677 645463005250 Lumazine binding domain; Region: Lum_binding; pfam00677 645463005251 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 645463005252 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 645463005253 catalytic motif [active] 645463005254 Zn binding site [ion binding]; other site 645463005255 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 645463005256 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 645463005257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463005258 ATP binding site [chemical binding]; other site 645463005259 putative Mg++ binding site [ion binding]; other site 645463005260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463005261 nucleotide binding region [chemical binding]; other site 645463005262 ATP-binding site [chemical binding]; other site 645463005263 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 645463005264 HRDC domain; Region: HRDC; pfam00570 645463005265 HRDC domain; Region: HRDC; pfam00570 645463005266 Helix-turn-helix domain; Region: HTH_40; pfam14493 645463005267 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 645463005268 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 645463005269 thiS-thiF/thiG interaction site; other site 645463005270 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 645463005271 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 645463005272 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 645463005273 ATP binding site [chemical binding]; other site 645463005274 substrate interface [chemical binding]; other site 645463005275 thiazole synthase; Reviewed; Region: thiG; PRK00208 645463005276 phosphate binding site [ion binding]; other site 645463005277 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 645463005278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463005279 FeS/SAM binding site; other site 645463005280 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 645463005281 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 645463005282 thiamine phosphate binding site [chemical binding]; other site 645463005283 active site 645463005284 pyrophosphate binding site [ion binding]; other site 645463005285 Predicted membrane protein [Function unknown]; Region: COG1288 645463005286 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645463005287 synthetase active site [active] 645463005288 NTP binding site [chemical binding]; other site 645463005289 metal binding site [ion binding]; metal-binding site 645463005290 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 645463005291 GTP binding site; other site 645463005292 CoA binding domain; Region: CoA_binding_2; pfam13380 645463005293 hypothetical protein; Provisional; Region: PRK00967 645463005294 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 645463005295 MPT binding site; other site 645463005296 trimer interface [polypeptide binding]; other site 645463005297 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 645463005298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463005299 FeS/SAM binding site; other site 645463005300 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 645463005301 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 645463005302 trimer interface [polypeptide binding]; other site 645463005303 dimer interface [polypeptide binding]; other site 645463005304 putative active site [active] 645463005305 MOSC domain; Region: MOSC; pfam03473 645463005306 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463005307 Na binding site [ion binding]; other site 645463005308 Protein of unknown function (DUF917); Region: DUF917; pfam06032 645463005309 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 645463005310 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 645463005311 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 645463005312 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 645463005313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 645463005314 putative acyl-acceptor binding pocket; other site 645463005315 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 645463005316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463005317 Helix-turn-helix domain; Region: HTH_18; pfam12833 645463005318 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 645463005319 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 645463005320 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645463005321 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645463005322 PhoU domain; Region: PhoU; pfam01895 645463005323 PhoU domain; Region: PhoU; pfam01895 645463005324 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 645463005325 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 645463005326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463005327 Coenzyme A binding pocket [chemical binding]; other site 645463005328 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 645463005329 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 645463005330 B12 binding site [chemical binding]; other site 645463005331 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 645463005332 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 645463005333 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 645463005334 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 645463005335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463005336 motif II; other site 645463005337 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 645463005338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005339 non-specific DNA binding site [nucleotide binding]; other site 645463005340 salt bridge; other site 645463005341 sequence-specific DNA binding site [nucleotide binding]; other site 645463005342 Cupin domain; Region: Cupin_2; pfam07883 645463005343 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 645463005344 fructuronate transporter; Provisional; Region: PRK10034; cl15264 645463005345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463005346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463005347 substrate binding pocket [chemical binding]; other site 645463005348 membrane-bound complex binding site; other site 645463005349 hinge residues; other site 645463005350 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 645463005351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005352 dimer interface [polypeptide binding]; other site 645463005353 phosphorylation site [posttranslational modification] 645463005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005355 ATP binding site [chemical binding]; other site 645463005356 Mg2+ binding site [ion binding]; other site 645463005357 G-X-G motif; other site 645463005358 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 645463005359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005360 active site 645463005361 phosphorylation site [posttranslational modification] 645463005362 intermolecular recognition site; other site 645463005363 dimerization interface [polypeptide binding]; other site 645463005364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463005365 Walker A motif; other site 645463005366 ATP binding site [chemical binding]; other site 645463005367 Walker B motif; other site 645463005368 arginine finger; other site 645463005369 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463005370 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 645463005371 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 645463005372 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 645463005373 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 645463005374 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 645463005375 active site 645463005376 purine riboside binding site [chemical binding]; other site 645463005377 EcsC protein family; Region: EcsC; pfam12787 645463005378 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 645463005379 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 645463005380 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463005381 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 645463005382 active site 645463005383 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005384 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005385 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463005387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463005388 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463005389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463005390 Walker A/P-loop; other site 645463005391 ATP binding site [chemical binding]; other site 645463005392 Q-loop/lid; other site 645463005393 ABC transporter signature motif; other site 645463005394 Walker B; other site 645463005395 D-loop; other site 645463005396 H-loop/switch region; other site 645463005397 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463005398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005399 non-specific DNA binding site [nucleotide binding]; other site 645463005400 salt bridge; other site 645463005401 sequence-specific DNA binding site [nucleotide binding]; other site 645463005402 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645463005403 active site 645463005404 catalytic residues [active] 645463005405 metal binding site [ion binding]; metal-binding site 645463005406 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 645463005407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463005408 Radical SAM superfamily; Region: Radical_SAM; pfam04055 645463005409 FeS/SAM binding site; other site 645463005410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463005411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463005412 S-adenosylmethionine binding site [chemical binding]; other site 645463005413 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 645463005414 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 645463005415 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 645463005416 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 645463005417 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 645463005418 B3/4 domain; Region: B3_4; cl19243 645463005419 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 645463005420 dimer interface [polypeptide binding]; other site 645463005421 ADP-ribose binding site [chemical binding]; other site 645463005422 active site 645463005423 nudix motif; other site 645463005424 metal binding site [ion binding]; metal-binding site 645463005425 Domain of unknown function (DUF4624); Region: DUF4624; pfam15417 645463005426 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 645463005427 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 645463005428 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 645463005429 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463005430 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 645463005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 645463005432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 645463005433 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 645463005434 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 645463005435 DNA binding site [nucleotide binding] 645463005436 active site 645463005437 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 645463005438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463005439 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463005440 substrate binding pocket [chemical binding]; other site 645463005441 membrane-bound complex binding site; other site 645463005442 hinge residues; other site 645463005443 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 645463005444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463005445 dimer interface [polypeptide binding]; other site 645463005446 conserved gate region; other site 645463005447 putative PBP binding loops; other site 645463005448 ABC-ATPase subunit interface; other site 645463005449 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645463005450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463005451 Walker A/P-loop; other site 645463005452 ATP binding site [chemical binding]; other site 645463005453 Q-loop/lid; other site 645463005454 ABC transporter signature motif; other site 645463005455 Walker B; other site 645463005456 D-loop; other site 645463005457 H-loop/switch region; other site 645463005458 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 645463005459 putative ArsC-like catalytic residues; other site 645463005460 putative TRX-like catalytic residues [active] 645463005461 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 645463005462 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 645463005463 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 645463005464 Ligand Binding Site [chemical binding]; other site 645463005465 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 645463005466 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 645463005467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463005468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005470 active site 645463005471 phosphorylation site [posttranslational modification] 645463005472 intermolecular recognition site; other site 645463005473 dimerization interface [polypeptide binding]; other site 645463005474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005475 DNA binding site [nucleotide binding] 645463005476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463005478 dimerization interface [polypeptide binding]; other site 645463005479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005480 dimer interface [polypeptide binding]; other site 645463005481 phosphorylation site [posttranslational modification] 645463005482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005483 ATP binding site [chemical binding]; other site 645463005484 Mg2+ binding site [ion binding]; other site 645463005485 G-X-G motif; other site 645463005486 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 645463005487 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 645463005488 dimerization interface 3.5A [polypeptide binding]; other site 645463005489 active site 645463005490 argininosuccinate synthase; Provisional; Region: PRK13820 645463005491 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 645463005492 ANP binding site [chemical binding]; other site 645463005493 Substrate Binding Site II [chemical binding]; other site 645463005494 Substrate Binding Site I [chemical binding]; other site 645463005495 NlpC/p60-like transpeptidase; Region: Transpep_BrtH; pfam14399 645463005496 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463005497 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 645463005498 DNA binding residues [nucleotide binding] 645463005499 dimer interface [polypeptide binding]; other site 645463005500 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 645463005501 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 645463005502 Predicted membrane protein [Function unknown]; Region: COG2323 645463005503 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 645463005504 active site 645463005505 catalytic site [active] 645463005506 substrate binding site [chemical binding]; other site 645463005507 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 645463005508 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 645463005509 NAD binding site [chemical binding]; other site 645463005510 homodimer interface [polypeptide binding]; other site 645463005511 active site 645463005512 putative substrate binding site [chemical binding]; other site 645463005513 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 645463005514 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 645463005515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645463005516 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 645463005517 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 645463005518 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463005519 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 645463005520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645463005521 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463005522 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 645463005523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 645463005524 active site residue [active] 645463005525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463005526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463005527 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 645463005528 putative dimerization interface [polypeptide binding]; other site 645463005529 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005530 putative metal binding site [ion binding]; other site 645463005531 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 645463005532 putative metal binding site [ion binding]; other site 645463005533 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463005534 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463005535 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463005536 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645463005537 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463005538 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005539 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005540 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463005541 Transcriptional regulators [Transcription]; Region: PurR; COG1609 645463005542 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 645463005543 DNA binding site [nucleotide binding] 645463005544 domain linker motif; other site 645463005545 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 645463005546 dimerization interface [polypeptide binding]; other site 645463005547 ligand binding site [chemical binding]; other site 645463005548 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 645463005549 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 645463005550 substrate binding [chemical binding]; other site 645463005551 active site 645463005552 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 645463005553 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 645463005554 putative substrate binding site [chemical binding]; other site 645463005555 putative ATP binding site [chemical binding]; other site 645463005556 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463005557 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 645463005558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 645463005559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463005560 catalytic residue [active] 645463005561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463005562 putative substrate translocation pore; other site 645463005563 Penicillinase repressor; Region: Pencillinase_R; pfam03965 645463005564 LytTr DNA-binding domain; Region: LytTR; smart00850 645463005565 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 645463005566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645463005567 catalytic core [active] 645463005568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463005569 flavoprotein, HI0933 family; Region: TIGR00275 645463005570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463005571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463005572 cytidylate kinase; Provisional; Region: cmk; PRK00023 645463005573 AAA domain; Region: AAA_17; cl19128 645463005574 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 645463005575 CMP-binding site; other site 645463005576 The sites determining sugar specificity; other site 645463005577 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 645463005578 putative acyl-acceptor binding pocket; other site 645463005579 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 645463005580 Fe-S cluster binding site [ion binding]; other site 645463005581 substrate binding site [chemical binding]; other site 645463005582 catalytic site [active] 645463005583 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 645463005584 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 645463005585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463005586 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 645463005587 active site 645463005588 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 645463005589 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 645463005590 catalytic triad [active] 645463005591 Protein of unknown function (DUF328); Region: DUF328; pfam03883 645463005592 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645463005593 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645463005594 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463005595 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 645463005596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463005597 motif II; other site 645463005598 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645463005599 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645463005600 homodimer interface [polypeptide binding]; other site 645463005601 substrate-cofactor binding pocket; other site 645463005602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463005603 catalytic residue [active] 645463005604 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 645463005605 proposed active site lysine [active] 645463005606 conserved cys residue [active] 645463005607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463005608 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463005609 putative DNA binding site [nucleotide binding]; other site 645463005610 putative Zn2+ binding site [ion binding]; other site 645463005611 FtsH Extracellular; Region: FtsH_ext; pfam06480 645463005612 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 645463005613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463005614 Walker A motif; other site 645463005615 ATP binding site [chemical binding]; other site 645463005616 Walker B motif; other site 645463005617 arginine finger; other site 645463005618 Peptidase family M41; Region: Peptidase_M41; pfam01434 645463005619 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 645463005620 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 645463005621 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 645463005622 Ligand Binding Site [chemical binding]; other site 645463005623 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 645463005624 GAF domain; Region: GAF_3; pfam13492 645463005625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005626 dimer interface [polypeptide binding]; other site 645463005627 phosphorylation site [posttranslational modification] 645463005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005629 ATP binding site [chemical binding]; other site 645463005630 Mg2+ binding site [ion binding]; other site 645463005631 G-X-G motif; other site 645463005632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005634 active site 645463005635 phosphorylation site [posttranslational modification] 645463005636 intermolecular recognition site; other site 645463005637 dimerization interface [polypeptide binding]; other site 645463005638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005639 DNA binding site [nucleotide binding] 645463005640 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 645463005641 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 645463005642 oligomer interface [polypeptide binding]; other site 645463005643 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 645463005644 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 645463005645 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 645463005646 active site 645463005647 dimer interface [polypeptide binding]; other site 645463005648 metal binding site [ion binding]; metal-binding site 645463005649 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 645463005650 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 645463005651 hinge; other site 645463005652 active site 645463005653 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 645463005654 Tetramer interface [polypeptide binding]; other site 645463005655 active site 645463005656 FMN-binding site [chemical binding]; other site 645463005657 Chorismate mutase type II; Region: CM_2; smart00830 645463005658 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 645463005659 Prephenate dehydratase; Region: PDT; pfam00800 645463005660 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 645463005661 putative L-Phe binding site [chemical binding]; other site 645463005662 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 645463005663 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 645463005664 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 645463005665 shikimate binding site; other site 645463005666 NAD(P) binding site [chemical binding]; other site 645463005667 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 645463005668 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 645463005669 ADP binding site [chemical binding]; other site 645463005670 magnesium binding site [ion binding]; other site 645463005671 putative shikimate binding site; other site 645463005672 prephenate dehydrogenase; Validated; Region: PRK08507 645463005673 Prephenate dehydrogenase; Region: PDH; pfam02153 645463005674 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 645463005675 metal binding site [ion binding]; metal-binding site 645463005676 nucleotidyl binding site; other site 645463005677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463005678 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 645463005679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463005680 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645463005681 putative active site [active] 645463005682 heme pocket [chemical binding]; other site 645463005683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463005684 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 645463005685 putative active site [active] 645463005686 heme pocket [chemical binding]; other site 645463005687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463005688 putative active site [active] 645463005689 heme pocket [chemical binding]; other site 645463005690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463005691 metal binding site [ion binding]; metal-binding site 645463005692 active site 645463005693 I-site; other site 645463005694 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 645463005695 putative active site [active] 645463005696 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 645463005697 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 645463005698 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463005699 putative catalytic residues [active] 645463005700 catalytic nucleophile [active] 645463005701 Recombinase; Region: Recombinase; pfam07508 645463005702 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463005703 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 645463005704 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 645463005705 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 645463005706 non-specific DNA binding site [nucleotide binding]; other site 645463005707 salt bridge; other site 645463005708 sequence-specific DNA binding site [nucleotide binding]; other site 645463005709 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 645463005710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005712 active site 645463005713 phosphorylation site [posttranslational modification] 645463005714 intermolecular recognition site; other site 645463005715 dimerization interface [polypeptide binding]; other site 645463005716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005717 DNA binding site [nucleotide binding] 645463005718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005720 dimer interface [polypeptide binding]; other site 645463005721 phosphorylation site [posttranslational modification] 645463005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005723 ATP binding site [chemical binding]; other site 645463005724 Mg2+ binding site [ion binding]; other site 645463005725 G-X-G motif; other site 645463005726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463005727 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 645463005728 Walker A/P-loop; other site 645463005729 ATP binding site [chemical binding]; other site 645463005730 Q-loop/lid; other site 645463005731 ABC transporter signature motif; other site 645463005732 Walker B; other site 645463005733 D-loop; other site 645463005734 H-loop/switch region; other site 645463005735 Acyltransferase family; Region: Acyl_transf_3; cl19154 645463005736 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463005737 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 645463005738 DNA binding residues [nucleotide binding] 645463005739 RNA polymerase sigma factor; Provisional; Region: PRK11924 645463005740 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645463005741 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 645463005742 DNA binding residues [nucleotide binding] 645463005743 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 645463005744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 645463005745 RelB antitoxin; Region: RelB; cl01171 645463005746 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 645463005747 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 645463005748 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 645463005749 hypothetical protein; Validated; Region: PRK08116 645463005750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463005751 Walker A motif; other site 645463005752 ATP binding site [chemical binding]; other site 645463005753 Walker B motif; other site 645463005754 arginine finger; other site 645463005755 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 645463005756 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463005757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005758 non-specific DNA binding site [nucleotide binding]; other site 645463005759 salt bridge; other site 645463005760 sequence-specific DNA binding site [nucleotide binding]; other site 645463005761 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 645463005762 CHC2 zinc finger; Region: zf-CHC2; cl17510 645463005763 Virulence-associated protein E; Region: VirE; pfam05272 645463005764 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463005765 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 645463005766 putative catalytic residues [active] 645463005767 catalytic nucleophile [active] 645463005768 Recombinase; Region: Recombinase; pfam07508 645463005769 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463005770 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 645463005771 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463005772 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 645463005773 putative catalytic residues [active] 645463005774 catalytic nucleophile [active] 645463005775 Recombinase; Region: Recombinase; pfam07508 645463005776 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463005777 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 645463005778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463005779 DNA binding residues [nucleotide binding] 645463005780 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 645463005781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463005782 FeS/SAM binding site; other site 645463005783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005784 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463005785 active site 645463005786 phosphorylation site [posttranslational modification] 645463005787 intermolecular recognition site; other site 645463005788 dimerization interface [polypeptide binding]; other site 645463005789 LytTr DNA-binding domain; Region: LytTR; smart00850 645463005790 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 645463005791 generic binding surface I; other site 645463005792 generic binding surface II; other site 645463005793 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 645463005794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463005795 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463005796 putative Zn2+ binding site [ion binding]; other site 645463005797 putative DNA binding site [nucleotide binding]; other site 645463005798 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463005799 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 645463005800 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463005801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005802 non-specific DNA binding site [nucleotide binding]; other site 645463005803 salt bridge; other site 645463005804 sequence-specific DNA binding site [nucleotide binding]; other site 645463005805 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 645463005806 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 645463005807 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645463005808 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 645463005809 MobA/MobL family; Region: MobA_MobL; pfam03389 645463005810 Virulence-associated protein E; Region: VirE; pfam05272 645463005811 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463005812 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 645463005813 putative catalytic residues [active] 645463005814 catalytic nucleophile [active] 645463005815 Recombinase; Region: Recombinase; pfam07508 645463005816 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463005817 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 645463005818 AAA-like domain; Region: AAA_10; pfam12846 645463005819 Domain of unknown function DUF87; Region: DUF87; cl19135 645463005820 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 645463005821 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 645463005822 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 645463005823 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 645463005824 active site 645463005825 putative interdomain interaction site [polypeptide binding]; other site 645463005826 putative metal-binding site [ion binding]; other site 645463005827 putative nucleotide binding site [chemical binding]; other site 645463005828 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645463005829 domain I; other site 645463005830 DNA binding groove [nucleotide binding] 645463005831 phosphate binding site [ion binding]; other site 645463005832 domain II; other site 645463005833 domain III; other site 645463005834 nucleotide binding site [chemical binding]; other site 645463005835 catalytic site [active] 645463005836 domain IV; other site 645463005837 KilA-N domain; Region: KilA-N; pfam04383 645463005838 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 645463005839 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 645463005840 Methyltransferase domain; Region: Methyltransf_26; pfam13659 645463005841 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 645463005842 DEAD-like helicases superfamily; Region: DEXDc; smart00487 645463005843 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 645463005844 helicase superfamily c-terminal domain; Region: HELICc; smart00490 645463005845 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 645463005846 AAA ATPase domain; Region: AAA_15; pfam13175 645463005847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463005848 Walker A/P-loop; other site 645463005849 ATP binding site [chemical binding]; other site 645463005850 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 645463005851 putative active site [active] 645463005852 putative metal-binding site [ion binding]; other site 645463005853 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 645463005854 Family description; Region: UvrD_C_2; pfam13538 645463005855 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 645463005856 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645463005857 catalytic residues [active] 645463005858 4Fe-4S binding domain; Region: Fer4_5; pfam12801 645463005859 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 645463005860 4Fe-4S binding domain; Region: Fer4_5; pfam12801 645463005861 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463005862 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 645463005863 Predicted permease; Region: FtsX; cl11418 645463005864 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463005865 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463005866 Walker A/P-loop; other site 645463005867 ATP binding site [chemical binding]; other site 645463005868 Q-loop/lid; other site 645463005869 ABC transporter signature motif; other site 645463005870 Walker B; other site 645463005871 D-loop; other site 645463005872 H-loop/switch region; other site 645463005873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463005874 FtsX-like permease family; Region: FtsX; pfam02687 645463005875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463005876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005877 active site 645463005878 phosphorylation site [posttranslational modification] 645463005879 intermolecular recognition site; other site 645463005880 dimerization interface [polypeptide binding]; other site 645463005881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463005882 DNA binding site [nucleotide binding] 645463005883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 645463005884 dimerization interface [polypeptide binding]; other site 645463005885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463005886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463005887 dimer interface [polypeptide binding]; other site 645463005888 phosphorylation site [posttranslational modification] 645463005889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005890 ATP binding site [chemical binding]; other site 645463005891 Mg2+ binding site [ion binding]; other site 645463005892 G-X-G motif; other site 645463005893 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645463005894 Cupin domain; Region: Cupin_2; pfam07883 645463005895 NMT1-like family; Region: NMT1_2; cl17432 645463005896 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 645463005897 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463005898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463005899 S-adenosylmethionine binding site [chemical binding]; other site 645463005900 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 645463005901 putative deacylase active site [active] 645463005902 YtxH-like protein; Region: YtxH; pfam12732 645463005903 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463005904 active site 645463005905 metal binding site [ion binding]; metal-binding site 645463005906 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 645463005907 catalytic motif [active] 645463005908 Zn binding site [ion binding]; other site 645463005909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463005910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463005911 non-specific DNA binding site [nucleotide binding]; other site 645463005912 salt bridge; other site 645463005913 sequence-specific DNA binding site [nucleotide binding]; other site 645463005914 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 645463005915 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645463005916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463005917 dimer interface [polypeptide binding]; other site 645463005918 conserved gate region; other site 645463005919 putative PBP binding loops; other site 645463005920 ABC-ATPase subunit interface; other site 645463005921 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463005922 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 645463005923 catalytic residues [active] 645463005924 catalytic nucleophile [active] 645463005925 Recombinase; Region: Recombinase; pfam07508 645463005926 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463005927 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 645463005928 putative active site [active] 645463005929 metal binding site [ion binding]; metal-binding site 645463005930 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 645463005931 putative hexamer interface [polypeptide binding]; other site 645463005932 putative hexagonal pore; other site 645463005933 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 645463005934 G1 box; other site 645463005935 GTP/Mg2+ binding site [chemical binding]; other site 645463005936 G2 box; other site 645463005937 Switch I region; other site 645463005938 G3 box; other site 645463005939 Switch II region; other site 645463005940 G4 box; other site 645463005941 G5 box; other site 645463005942 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 645463005943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463005944 active site 645463005945 phosphorylation site [posttranslational modification] 645463005946 intermolecular recognition site; other site 645463005947 dimerization interface [polypeptide binding]; other site 645463005948 ANTAR domain; Region: ANTAR; pfam03861 645463005949 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 645463005950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 645463005951 Histidine kinase; Region: HisKA_2; pfam07568 645463005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463005953 ATP binding site [chemical binding]; other site 645463005954 Mg2+ binding site [ion binding]; other site 645463005955 G-X-G motif; other site 645463005956 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 645463005957 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 645463005958 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 645463005959 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 645463005960 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 645463005961 putative hexamer interface [polypeptide binding]; other site 645463005962 putative hexagonal pore; other site 645463005963 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 645463005964 putative hexamer interface [polypeptide binding]; other site 645463005965 putative hexagonal pore; other site 645463005966 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 645463005967 Hexamer interface [polypeptide binding]; other site 645463005968 Hexagonal pore residue; other site 645463005969 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 645463005970 putative catalytic cysteine [active] 645463005971 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 645463005972 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 645463005973 Hexamer interface [polypeptide binding]; other site 645463005974 Putative hexagonal pore residue; other site 645463005975 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 645463005976 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 645463005977 Propanediol utilisation protein PduL; Region: PduL; pfam06130 645463005978 Propanediol utilisation protein PduL; Region: PduL; pfam06130 645463005979 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 645463005980 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 645463005981 Hexamer/Pentamer interface [polypeptide binding]; other site 645463005982 central pore; other site 645463005983 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 645463005984 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 645463005985 putative hexamer interface [polypeptide binding]; other site 645463005986 putative hexagonal pore; other site 645463005987 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 645463005988 putative hexamer interface [polypeptide binding]; other site 645463005989 putative hexagonal pore; other site 645463005990 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 645463005991 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 645463005992 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 645463005993 MarR family; Region: MarR_2; cl17246 645463005994 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463005995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463005996 putative DNA binding site [nucleotide binding]; other site 645463005997 putative Zn2+ binding site [ion binding]; other site 645463005998 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463005999 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 645463006000 metal binding site [ion binding]; metal-binding site 645463006001 putative dimer interface [polypeptide binding]; other site 645463006002 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 645463006003 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463006004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463006005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463006006 homodimer interface [polypeptide binding]; other site 645463006007 catalytic residue [active] 645463006008 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 645463006009 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 645463006010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 645463006011 ligand binding site [chemical binding]; other site 645463006012 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 645463006013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463006014 LexA repressor; Validated; Region: PRK00215 645463006015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463006016 putative DNA binding site [nucleotide binding]; other site 645463006017 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 645463006018 Catalytic site [active] 645463006019 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 645463006020 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463006021 active site 645463006022 DNA binding site [nucleotide binding] 645463006023 Int/Topo IB signature motif; other site 645463006024 Uncharacterized conserved protein [Function unknown]; Region: COG3603 645463006025 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like; cd04868 645463006026 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 645463006027 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 645463006028 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 645463006029 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 645463006030 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463006031 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645463006032 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 645463006033 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 645463006034 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 645463006035 carboxyltransferase (CT) interaction site; other site 645463006036 biotinylation site [posttranslational modification]; other site 645463006037 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 645463006038 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 645463006039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 645463006040 active site 645463006041 metal binding site [ion binding]; metal-binding site 645463006042 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 645463006043 Helix-turn-helix domain; Region: HTH_18; pfam12833 645463006044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463006045 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463006046 Walker A/P-loop; other site 645463006047 ATP binding site [chemical binding]; other site 645463006048 Q-loop/lid; other site 645463006049 ABC transporter signature motif; other site 645463006050 Walker B; other site 645463006051 D-loop; other site 645463006052 H-loop/switch region; other site 645463006053 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463006054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463006055 FtsX-like permease family; Region: FtsX; pfam02687 645463006056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463006057 FtsX-like permease family; Region: FtsX; pfam02687 645463006058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463006059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463006060 dimer interface [polypeptide binding]; other site 645463006061 phosphorylation site [posttranslational modification] 645463006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463006063 ATP binding site [chemical binding]; other site 645463006064 Mg2+ binding site [ion binding]; other site 645463006065 G-X-G motif; other site 645463006066 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463006067 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463006068 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645463006069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645463006070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463006071 Coenzyme A binding pocket [chemical binding]; other site 645463006072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463006073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463006074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645463006075 dimerization interface [polypeptide binding]; other site 645463006076 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 645463006077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463006078 FtsX-like permease family; Region: FtsX; pfam02687 645463006079 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463006080 FtsX-like permease family; Region: FtsX; pfam02687 645463006081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463006082 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463006083 Walker A/P-loop; other site 645463006084 ATP binding site [chemical binding]; other site 645463006085 Q-loop/lid; other site 645463006086 ABC transporter signature motif; other site 645463006087 Walker B; other site 645463006088 D-loop; other site 645463006089 H-loop/switch region; other site 645463006090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463006091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463006092 dimer interface [polypeptide binding]; other site 645463006093 phosphorylation site [posttranslational modification] 645463006094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463006095 ATP binding site [chemical binding]; other site 645463006096 Mg2+ binding site [ion binding]; other site 645463006097 G-X-G motif; other site 645463006098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463006099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463006100 active site 645463006101 phosphorylation site [posttranslational modification] 645463006102 intermolecular recognition site; other site 645463006103 dimerization interface [polypeptide binding]; other site 645463006104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463006105 DNA binding site [nucleotide binding] 645463006106 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 645463006107 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463006108 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463006109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463006111 active site 645463006112 phosphorylation site [posttranslational modification] 645463006113 intermolecular recognition site; other site 645463006114 dimerization interface [polypeptide binding]; other site 645463006115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463006116 DNA binding site [nucleotide binding] 645463006117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463006118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463006119 dimer interface [polypeptide binding]; other site 645463006120 phosphorylation site [posttranslational modification] 645463006121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463006122 ATP binding site [chemical binding]; other site 645463006123 Mg2+ binding site [ion binding]; other site 645463006124 G-X-G motif; other site 645463006125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463006126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463006127 Walker A/P-loop; other site 645463006128 ATP binding site [chemical binding]; other site 645463006129 Q-loop/lid; other site 645463006130 ABC transporter signature motif; other site 645463006131 Walker B; other site 645463006132 D-loop; other site 645463006133 H-loop/switch region; other site 645463006134 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 645463006135 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463006136 FtsX-like permease family; Region: FtsX; pfam02687 645463006137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463006138 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463006139 FtsX-like permease family; Region: FtsX; pfam02687 645463006140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463006141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463006142 S-adenosylmethionine binding site [chemical binding]; other site 645463006143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463006144 WHG domain; Region: WHG; pfam13305 645463006145 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463006146 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 645463006147 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 645463006148 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 645463006149 Protein of unknown function (DUF554); Region: DUF554; pfam04474 645463006150 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 645463006151 putative deacylase active site [active] 645463006152 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 645463006153 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 645463006154 hypothetical protein; Provisional; Region: PRK07205 645463006155 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645463006156 active site 645463006157 metal binding site [ion binding]; metal-binding site 645463006158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 645463006159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463006160 catalytic residue [active] 645463006161 bacterial Hfq-like; Region: Hfq; cd01716 645463006162 hexamer interface [polypeptide binding]; other site 645463006163 Sm1 motif; other site 645463006164 RNA binding site [nucleotide binding]; other site 645463006165 Sm2 motif; other site 645463006166 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 645463006167 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 645463006168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463006169 ATP binding site [chemical binding]; other site 645463006170 Mg2+ binding site [ion binding]; other site 645463006171 G-X-G motif; other site 645463006172 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 645463006173 ATP binding site [chemical binding]; other site 645463006174 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 645463006175 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 645463006176 MutS domain I; Region: MutS_I; pfam01624 645463006177 MutS domain II; Region: MutS_II; pfam05188 645463006178 MutS domain III; Region: MutS_III; pfam05192 645463006179 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 645463006180 Walker A/P-loop; other site 645463006181 ATP binding site [chemical binding]; other site 645463006182 Q-loop/lid; other site 645463006183 ABC transporter signature motif; other site 645463006184 Walker B; other site 645463006185 D-loop; other site 645463006186 H-loop/switch region; other site 645463006187 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645463006188 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 645463006189 Walker A/P-loop; other site 645463006190 ATP binding site [chemical binding]; other site 645463006191 Q-loop/lid; other site 645463006192 ABC transporter signature motif; other site 645463006193 Walker B; other site 645463006194 D-loop; other site 645463006195 H-loop/switch region; other site 645463006196 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 645463006197 NMT1/THI5 like; Region: NMT1; pfam09084 645463006198 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645463006199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463006200 dimer interface [polypeptide binding]; other site 645463006201 conserved gate region; other site 645463006202 putative PBP binding loops; other site 645463006203 ABC-ATPase subunit interface; other site 645463006204 Domain of unknown function DUF77; Region: DUF77; pfam01910 645463006205 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463006206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463006207 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463006208 Probable transposase; Region: OrfB_IS605; pfam01385 645463006209 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463006210 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 645463006211 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 645463006212 putative active site [active] 645463006213 putative CoA binding site [chemical binding]; other site 645463006214 nudix motif; other site 645463006215 metal binding site [ion binding]; metal-binding site 645463006216 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 645463006217 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 645463006218 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645463006219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463006220 FeS/SAM binding site; other site 645463006221 TRAM domain; Region: TRAM; pfam01938 645463006222 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006223 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006224 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006225 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 645463006226 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463006227 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463006228 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645463006229 DNA-binding site [nucleotide binding]; DNA binding site 645463006230 RNA-binding motif; other site 645463006231 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 645463006232 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 645463006233 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 645463006234 Predicted integral membrane protein [Function unknown]; Region: COG5658 645463006235 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 645463006236 SdpI/YhfL protein family; Region: SdpI; pfam13630 645463006237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463006238 dimerization interface [polypeptide binding]; other site 645463006239 putative DNA binding site [nucleotide binding]; other site 645463006240 putative Zn2+ binding site [ion binding]; other site 645463006241 hypothetical protein; Provisional; Region: PRK10621 645463006242 Cupin domain; Region: Cupin_2; cl17218 645463006243 Sensory domain found in PocR; Region: PocR; pfam10114 645463006244 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463006245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463006246 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463006247 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 645463006248 DNA binding residues [nucleotide binding] 645463006249 putative dimer interface [polypeptide binding]; other site 645463006250 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 645463006251 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 645463006252 flavodoxin, short chain; Region: flav_short; TIGR01753 645463006253 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 645463006254 Subtilase family; Region: Peptidase_S8; pfam00082 645463006255 active site 645463006256 catalytic residues [active] 645463006257 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 645463006258 VanZ like family; Region: VanZ; pfam04892 645463006259 L-aspartate oxidase; Provisional; Region: PRK06175 645463006260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006261 non-specific DNA binding site [nucleotide binding]; other site 645463006262 salt bridge; other site 645463006263 sequence-specific DNA binding site [nucleotide binding]; other site 645463006264 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645463006265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 645463006266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463006267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463006268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463006269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463006270 putative substrate translocation pore; other site 645463006271 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 645463006272 Clp amino terminal domain; Region: Clp_N; pfam02861 645463006273 Clp amino terminal domain; Region: Clp_N; pfam02861 645463006274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463006275 Walker A motif; other site 645463006276 ATP binding site [chemical binding]; other site 645463006277 Walker B motif; other site 645463006278 arginine finger; other site 645463006279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463006280 Walker A motif; other site 645463006281 ATP binding site [chemical binding]; other site 645463006282 Walker B motif; other site 645463006283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 645463006284 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 645463006285 Predicted transcriptional regulators [Transcription]; Region: COG1725 645463006286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463006287 DNA-binding site [nucleotide binding]; DNA binding site 645463006288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463006289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463006290 Walker A/P-loop; other site 645463006291 ATP binding site [chemical binding]; other site 645463006292 Q-loop/lid; other site 645463006293 ABC transporter signature motif; other site 645463006294 Walker B; other site 645463006295 D-loop; other site 645463006296 H-loop/switch region; other site 645463006297 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 645463006298 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463006299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463006300 Coenzyme A binding pocket [chemical binding]; other site 645463006301 allantoate amidohydrolase; Reviewed; Region: PRK09290 645463006302 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 645463006303 active site 645463006304 metal binding site [ion binding]; metal-binding site 645463006305 dimer interface [polypeptide binding]; other site 645463006306 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 645463006307 ornithine carbamoyltransferase; Validated; Region: PRK02102 645463006308 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 645463006309 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 645463006310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645463006311 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 645463006312 inhibitor-cofactor binding pocket; inhibition site 645463006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463006314 catalytic residue [active] 645463006315 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 645463006316 feedback inhibition sensing region; other site 645463006317 homohexameric interface [polypeptide binding]; other site 645463006318 nucleotide binding site [chemical binding]; other site 645463006319 N-acetyl-L-glutamate binding site [chemical binding]; other site 645463006320 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 645463006321 heterotetramer interface [polypeptide binding]; other site 645463006322 active site pocket [active] 645463006323 cleavage site 645463006324 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 645463006325 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 645463006326 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 645463006327 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 645463006328 YoaP-like; Region: YoaP; pfam14268 645463006329 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463006330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463006331 Coenzyme A binding pocket [chemical binding]; other site 645463006332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463006333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463006334 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 645463006335 WHG domain; Region: WHG; pfam13305 645463006336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463006337 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 645463006338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006339 salt bridge; other site 645463006340 non-specific DNA binding site [nucleotide binding]; other site 645463006341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463006342 sequence-specific DNA binding site [nucleotide binding]; other site 645463006343 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463006344 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463006345 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463006346 putative active site [active] 645463006347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463006348 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 645463006349 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 645463006350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463006351 RNA binding surface [nucleotide binding]; other site 645463006352 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 645463006353 active site 645463006354 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645463006355 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 645463006356 diaminopimelate decarboxylase; Region: lysA; TIGR01048 645463006357 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 645463006358 active site 645463006359 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463006360 substrate binding site [chemical binding]; other site 645463006361 catalytic residues [active] 645463006362 dimer interface [polypeptide binding]; other site 645463006363 aspartate kinase; Reviewed; Region: PRK06635 645463006364 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 645463006365 putative nucleotide binding site [chemical binding]; other site 645463006366 putative catalytic residues [active] 645463006367 putative Mg ion binding site [ion binding]; other site 645463006368 putative aspartate binding site [chemical binding]; other site 645463006369 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 645463006370 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 645463006371 putative allosteric regulatory residue; other site 645463006372 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 645463006373 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 645463006374 active site 645463006375 HIGH motif; other site 645463006376 KMSKS motif; other site 645463006377 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 645463006378 putative lipid kinase; Reviewed; Region: PRK13059 645463006379 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 645463006380 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 645463006381 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 645463006382 Penicillinase repressor; Region: Penicillinase_R; cl17580 645463006383 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 645463006384 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 645463006385 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 645463006386 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 645463006387 Int/Topo IB signature motif; other site 645463006388 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 645463006389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463006390 Walker A/P-loop; other site 645463006391 ATP binding site [chemical binding]; other site 645463006392 ABC transporter signature motif; other site 645463006393 Walker B; other site 645463006394 D-loop; other site 645463006395 H-loop/switch region; other site 645463006396 ABC transporter; Region: ABC_tran_2; pfam12848 645463006397 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463006398 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 645463006399 putative MPT binding site; other site 645463006400 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 645463006401 Ligand binding site; other site 645463006402 metal-binding site 645463006403 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 645463006404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463006405 Probable transposase; Region: OrfB_IS605; pfam01385 645463006406 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463006407 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 645463006408 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645463006409 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645463006410 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 645463006411 FAD binding domain; Region: FAD_binding_4; cl19922 645463006412 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 645463006413 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463006414 xanthine permease; Region: pbuX; TIGR03173 645463006415 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 645463006416 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645463006417 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 645463006418 phosphate binding site [ion binding]; other site 645463006419 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 645463006420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463006421 active site 645463006422 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 645463006423 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645463006424 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645463006425 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 645463006426 FAD binding domain; Region: FAD_binding_4; cl19922 645463006427 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 645463006428 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 645463006429 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463006430 catalytic loop [active] 645463006431 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 645463006432 iron binding site [ion binding]; other site 645463006433 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 645463006434 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 645463006435 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 645463006436 active site 645463006437 putative substrate binding pocket [chemical binding]; other site 645463006438 phenylhydantoinase; Validated; Region: PRK08323 645463006439 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 645463006440 tetramer interface [polypeptide binding]; other site 645463006441 active site 645463006442 peptidase; Reviewed; Region: PRK13004 645463006443 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 645463006444 putative metal binding site [ion binding]; other site 645463006445 putative dimer interface [polypeptide binding]; other site 645463006446 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 645463006447 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 645463006448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463006449 catalytic residue [active] 645463006450 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463006451 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 645463006452 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 645463006453 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645463006454 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645463006455 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 645463006456 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463006457 catalytic loop [active] 645463006458 iron binding site [ion binding]; other site 645463006459 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 645463006460 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 645463006461 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 645463006462 active site 645463006463 putative substrate binding pocket [chemical binding]; other site 645463006464 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463006465 xanthine permease; Region: pbuX; TIGR03173 645463006466 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463006467 xanthine permease; Region: pbuX; TIGR03173 645463006468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463006469 Walker A motif; other site 645463006470 ATP binding site [chemical binding]; other site 645463006471 Walker B motif; other site 645463006472 arginine finger; other site 645463006473 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 645463006474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 645463006475 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 645463006476 Predicted transcriptional regulator [Transcription]; Region: COG2378 645463006477 HTH domain; Region: HTH_11; pfam08279 645463006478 WYL domain; Region: WYL; pfam13280 645463006479 QueT transporter; Region: QueT; pfam06177 645463006480 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 645463006481 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645463006482 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645463006483 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 645463006484 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463006485 catalytic loop [active] 645463006486 iron binding site [ion binding]; other site 645463006487 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 645463006488 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 645463006489 FAD binding domain; Region: FAD_binding_4; cl19922 645463006490 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 645463006491 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 645463006492 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 645463006493 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 645463006494 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 645463006495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463006496 Walker A/P-loop; other site 645463006497 ATP binding site [chemical binding]; other site 645463006498 Q-loop/lid; other site 645463006499 ABC transporter signature motif; other site 645463006500 Walker B; other site 645463006501 D-loop; other site 645463006502 H-loop/switch region; other site 645463006503 helicase 45; Provisional; Region: PTZ00424 645463006504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645463006505 ATP binding site [chemical binding]; other site 645463006506 putative Mg++ binding site [ion binding]; other site 645463006507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463006508 nucleotide binding region [chemical binding]; other site 645463006509 ATP-binding site [chemical binding]; other site 645463006510 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 645463006511 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463006512 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 645463006513 anion transporter; Region: dass; TIGR00785 645463006514 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 645463006515 transmembrane helices; other site 645463006516 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 645463006517 active site 645463006518 intersubunit interactions; other site 645463006519 catalytic residue [active] 645463006520 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645463006521 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 645463006522 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645463006523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463006524 dimer interface [polypeptide binding]; other site 645463006525 phosphorylation site [posttranslational modification] 645463006526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463006527 ATP binding site [chemical binding]; other site 645463006528 G-X-G motif; other site 645463006529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463006530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463006531 active site 645463006532 phosphorylation site [posttranslational modification] 645463006533 intermolecular recognition site; other site 645463006534 dimerization interface [polypeptide binding]; other site 645463006535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463006536 DNA binding site [nucleotide binding] 645463006537 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645463006538 metal-binding site [ion binding] 645463006539 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 645463006540 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 645463006541 metal-binding site [ion binding] 645463006542 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463006543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463006544 motif II; other site 645463006545 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 645463006546 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 645463006547 G1 box; other site 645463006548 putative GEF interaction site [polypeptide binding]; other site 645463006549 GTP/Mg2+ binding site [chemical binding]; other site 645463006550 Switch I region; other site 645463006551 G2 box; other site 645463006552 G3 box; other site 645463006553 Switch II region; other site 645463006554 G4 box; other site 645463006555 G5 box; other site 645463006556 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 645463006557 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 645463006558 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 645463006559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 645463006560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463006561 threonine synthase; Validated; Region: PRK09225 645463006562 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 645463006563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463006564 catalytic residue [active] 645463006565 homoserine kinase; Provisional; Region: PRK01212 645463006566 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645463006567 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645463006568 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 645463006569 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 645463006570 FMN binding site [chemical binding]; other site 645463006571 substrate binding site [chemical binding]; other site 645463006572 putative catalytic residue [active] 645463006573 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 645463006574 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 645463006575 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 645463006576 Cl binding site [ion binding]; other site 645463006577 oligomer interface [polypeptide binding]; other site 645463006578 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 645463006579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463006580 binding surface 645463006581 TPR motif; other site 645463006582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463006583 binding surface 645463006584 TPR motif; other site 645463006585 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 645463006586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463006587 binding surface 645463006588 TPR motif; other site 645463006589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463006590 binding surface 645463006591 TPR motif; other site 645463006592 Predicted permeases [General function prediction only]; Region: COG0679 645463006593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645463006594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463006595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 645463006596 Coenzyme A binding pocket [chemical binding]; other site 645463006597 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 645463006598 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 645463006599 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 645463006600 RIP metalloprotease RseP; Region: TIGR00054 645463006601 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 645463006602 active site 645463006603 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 645463006604 protein binding site [polypeptide binding]; other site 645463006605 putative substrate binding region [chemical binding]; other site 645463006606 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 645463006607 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 645463006608 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 645463006609 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 645463006610 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 645463006611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463006612 metal binding site [ion binding]; metal-binding site 645463006613 active site 645463006614 I-site; other site 645463006615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463006616 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 645463006617 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 645463006618 active site 645463006619 dimer interface [polypeptide binding]; other site 645463006620 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 645463006621 hinge region; other site 645463006622 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 645463006623 putative nucleotide binding site [chemical binding]; other site 645463006624 uridine monophosphate binding site [chemical binding]; other site 645463006625 homohexameric interface [polypeptide binding]; other site 645463006626 elongation factor Ts; Provisional; Region: tsf; PRK09377 645463006627 UBA/TS-N domain; Region: UBA; pfam00627 645463006628 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 645463006629 rRNA interaction site [nucleotide binding]; other site 645463006630 S8 interaction site; other site 645463006631 putative laminin-1 binding site; other site 645463006632 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 645463006633 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 645463006634 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 645463006635 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 645463006636 Ion channel; Region: Ion_trans_2; pfam07885 645463006637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463006638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006639 non-specific DNA binding site [nucleotide binding]; other site 645463006640 salt bridge; other site 645463006641 sequence-specific DNA binding site [nucleotide binding]; other site 645463006642 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 645463006643 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 645463006644 Domain of unknown function DUF; Region: DUF204; pfam02659 645463006645 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 645463006646 MutS domain III; Region: MutS_III; pfam05192 645463006647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463006648 Walker A/P-loop; other site 645463006649 ATP binding site [chemical binding]; other site 645463006650 Q-loop/lid; other site 645463006651 ABC transporter signature motif; other site 645463006652 Walker B; other site 645463006653 D-loop; other site 645463006654 H-loop/switch region; other site 645463006655 hypothetical protein; Reviewed; Region: PRK09588 645463006656 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 645463006657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 645463006658 active site 645463006659 ATP binding site [chemical binding]; other site 645463006660 substrate binding site [chemical binding]; other site 645463006661 activation loop (A-loop); other site 645463006662 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645463006663 VanW like protein; Region: VanW; pfam04294 645463006664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 645463006665 putative catalytic site [active] 645463006666 putative metal binding site [ion binding]; other site 645463006667 putative phosphate binding site [ion binding]; other site 645463006668 Protein of unknown function (DUF819); Region: DUF819; cl02317 645463006669 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 645463006670 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 645463006671 putative oligomer interface [polypeptide binding]; other site 645463006672 putative active site [active] 645463006673 metal binding site [ion binding]; metal-binding site 645463006674 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 645463006675 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 645463006676 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 645463006677 G1 box; other site 645463006678 GTP/Mg2+ binding site [chemical binding]; other site 645463006679 Switch I region; other site 645463006680 G2 box; other site 645463006681 Switch II region; other site 645463006682 G3 box; other site 645463006683 G4 box; other site 645463006684 G5 box; other site 645463006685 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 645463006686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463006687 FeS/SAM binding site; other site 645463006688 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 645463006689 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 645463006690 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 645463006691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 645463006692 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 645463006693 inhibitor-cofactor binding pocket; inhibition site 645463006694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463006695 catalytic residue [active] 645463006696 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 645463006697 VanZ like family; Region: VanZ; pfam04892 645463006698 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463006699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463006700 Coenzyme A binding pocket [chemical binding]; other site 645463006701 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 645463006702 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 645463006703 DHHA1 domain; Region: DHHA1; pfam02272 645463006704 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 645463006705 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463006706 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 645463006707 NAD binding site [chemical binding]; other site 645463006708 dimer interface [polypeptide binding]; other site 645463006709 substrate binding site [chemical binding]; other site 645463006710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006711 non-specific DNA binding site [nucleotide binding]; other site 645463006712 salt bridge; other site 645463006713 sequence-specific DNA binding site [nucleotide binding]; other site 645463006714 Domain of unknown function (DUF955); Region: DUF955; cl01076 645463006715 methionine sulfoxide reductase A; Provisional; Region: PRK14054 645463006716 methionine sulfoxide reductase B; Provisional; Region: PRK00222 645463006717 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 645463006718 active site 645463006719 nucleophile elbow; other site 645463006720 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 645463006721 cubane metal cluster [ion binding]; other site 645463006722 hybrid metal cluster; other site 645463006723 Ferredoxin [Energy production and conversion]; Region: COG1146 645463006724 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463006725 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645463006726 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645463006727 ligand binding site [chemical binding]; other site 645463006728 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 645463006729 non-specific DNA interactions [nucleotide binding]; other site 645463006730 DNA binding site [nucleotide binding] 645463006731 sequence specific DNA binding site [nucleotide binding]; other site 645463006732 putative cAMP binding site [chemical binding]; other site 645463006733 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 645463006734 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 645463006735 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 645463006736 Walker A/P-loop; other site 645463006737 ATP binding site [chemical binding]; other site 645463006738 Q-loop/lid; other site 645463006739 ABC transporter signature motif; other site 645463006740 Walker B; other site 645463006741 D-loop; other site 645463006742 H-loop/switch region; other site 645463006743 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463006744 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463006745 metal binding site [ion binding]; metal-binding site 645463006746 dimer interface [polypeptide binding]; other site 645463006747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463006748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463006749 substrate binding pocket [chemical binding]; other site 645463006750 membrane-bound complex binding site; other site 645463006751 hinge residues; other site 645463006752 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 645463006753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463006754 dimer interface [polypeptide binding]; other site 645463006755 conserved gate region; other site 645463006756 putative PBP binding loops; other site 645463006757 ABC-ATPase subunit interface; other site 645463006758 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 645463006759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463006760 dimer interface [polypeptide binding]; other site 645463006761 conserved gate region; other site 645463006762 putative PBP binding loops; other site 645463006763 ABC-ATPase subunit interface; other site 645463006764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463006765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 645463006766 substrate binding pocket [chemical binding]; other site 645463006767 membrane-bound complex binding site; other site 645463006768 hinge residues; other site 645463006769 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 645463006770 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463006771 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 645463006772 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 645463006773 molybdopterin cofactor binding site; other site 645463006774 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 645463006775 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 645463006776 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 645463006777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463006778 ATP binding site [chemical binding]; other site 645463006779 putative Mg++ binding site [ion binding]; other site 645463006780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463006781 nucleotide binding region [chemical binding]; other site 645463006782 ATP-binding site [chemical binding]; other site 645463006783 Putative lysophospholipase; Region: Hydrolase_4; cl19140 645463006784 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463006785 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 645463006786 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 645463006787 ATP binding site [chemical binding]; other site 645463006788 Mg++ binding site [ion binding]; other site 645463006789 motif III; other site 645463006790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463006791 nucleotide binding region [chemical binding]; other site 645463006792 ATP-binding site [chemical binding]; other site 645463006793 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 645463006794 RNA binding site [nucleotide binding]; other site 645463006795 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463006796 active site 645463006797 metal binding site [ion binding]; metal-binding site 645463006798 Domain of unknown function DUF11; Region: DUF11; cl17728 645463006799 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 645463006800 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 645463006801 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 645463006802 maltose phosphorylase; Provisional; Region: PRK13807 645463006803 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 645463006804 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 645463006805 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 645463006806 beta-phosphoglucomutase; Region: bPGM; TIGR01990 645463006807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463006808 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 645463006809 homodimer interface [polypeptide binding]; other site 645463006810 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 645463006811 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 645463006812 active site 645463006813 homodimer interface [polypeptide binding]; other site 645463006814 catalytic site [active] 645463006815 histidinol-phosphatase; Provisional; Region: PRK05588 645463006816 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 645463006817 active site 645463006818 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 645463006819 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006820 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006821 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463006822 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 645463006823 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 645463006824 non-specific DNA interactions [nucleotide binding]; other site 645463006825 DNA binding site [nucleotide binding] 645463006826 sequence specific DNA binding site [nucleotide binding]; other site 645463006827 putative cAMP binding site [chemical binding]; other site 645463006828 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463006829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463006830 nucleotide binding site [chemical binding]; other site 645463006831 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 645463006832 Ferritin-like domain; Region: Ferritin; pfam00210 645463006833 ferroxidase diiron center [ion binding]; other site 645463006834 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 645463006835 CoA binding domain; Region: CoA_binding_2; pfam13380 645463006836 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 645463006837 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 645463006838 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 645463006839 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 645463006840 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 645463006841 TPP-binding site [chemical binding]; other site 645463006842 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 645463006843 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 645463006844 dimer interface [polypeptide binding]; other site 645463006845 PYR/PP interface [polypeptide binding]; other site 645463006846 TPP binding site [chemical binding]; other site 645463006847 substrate binding site [chemical binding]; other site 645463006848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463006849 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463006850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463006851 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 645463006852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463006853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463006854 homodimer interface [polypeptide binding]; other site 645463006855 catalytic residue [active] 645463006856 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 645463006857 MFS/sugar transport protein; Region: MFS_2; pfam13347 645463006858 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 645463006859 Na binding site [ion binding]; other site 645463006860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463006861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463006862 Putative esterase; Region: Esterase; pfam00756 645463006863 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 645463006864 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645463006865 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645463006866 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 645463006867 NAD(P) binding site [chemical binding]; other site 645463006868 catalytic residues [active] 645463006869 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 645463006870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463006871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463006872 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 645463006873 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 645463006874 HflX GTPase family; Region: HflX; cd01878 645463006875 G1 box; other site 645463006876 GTP/Mg2+ binding site [chemical binding]; other site 645463006877 Switch I region; other site 645463006878 G2 box; other site 645463006879 G3 box; other site 645463006880 Switch II region; other site 645463006881 G4 box; other site 645463006882 G5 box; other site 645463006883 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463006884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463006885 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645463006886 Walker A/P-loop; other site 645463006887 ATP binding site [chemical binding]; other site 645463006888 Q-loop/lid; other site 645463006889 ABC transporter signature motif; other site 645463006890 Walker B; other site 645463006891 D-loop; other site 645463006892 H-loop/switch region; other site 645463006893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463006894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463006895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463006896 Walker A/P-loop; other site 645463006897 ATP binding site [chemical binding]; other site 645463006898 Q-loop/lid; other site 645463006899 ABC transporter signature motif; other site 645463006900 Walker B; other site 645463006901 D-loop; other site 645463006902 H-loop/switch region; other site 645463006903 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463006904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463006905 putative DNA binding site [nucleotide binding]; other site 645463006906 putative Zn2+ binding site [ion binding]; other site 645463006907 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 645463006908 active site clefts [active] 645463006909 zinc binding site [ion binding]; other site 645463006910 dimer interface [polypeptide binding]; other site 645463006911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006912 non-specific DNA binding site [nucleotide binding]; other site 645463006913 salt bridge; other site 645463006914 sequence-specific DNA binding site [nucleotide binding]; other site 645463006915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463006916 non-specific DNA binding site [nucleotide binding]; other site 645463006917 salt bridge; other site 645463006918 sequence-specific DNA binding site [nucleotide binding]; other site 645463006919 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 645463006920 active site 645463006921 catalytic residue [active] 645463006922 dimer interface [polypeptide binding]; other site 645463006923 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 645463006924 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 645463006925 trimer interface [polypeptide binding]; other site 645463006926 active site 645463006927 substrate binding site [chemical binding]; other site 645463006928 CoA binding site [chemical binding]; other site 645463006929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463006930 Radical SAM superfamily; Region: Radical_SAM; pfam04055 645463006931 FeS/SAM binding site; other site 645463006932 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 645463006933 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 645463006934 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 645463006935 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 645463006936 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645463006937 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 645463006938 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463006939 4Fe-4S binding domain; Region: Fer4; pfam00037 645463006940 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 645463006941 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 645463006942 FAD binding pocket [chemical binding]; other site 645463006943 FAD binding motif [chemical binding]; other site 645463006944 phosphate binding motif [ion binding]; other site 645463006945 beta-alpha-beta structure motif; other site 645463006946 NAD binding pocket [chemical binding]; other site 645463006947 Iron coordination center [ion binding]; other site 645463006948 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 645463006949 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463006950 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 645463006951 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 645463006952 ligand binding site [chemical binding]; other site 645463006953 flexible hinge region; other site 645463006954 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 645463006955 putative switch regulator; other site 645463006956 non-specific DNA interactions [nucleotide binding]; other site 645463006957 DNA binding site [nucleotide binding] 645463006958 sequence specific DNA binding site [nucleotide binding]; other site 645463006959 putative cAMP binding site [chemical binding]; other site 645463006960 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463006961 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463006962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463006963 putative active site [active] 645463006964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463006965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463006966 nucleotide binding site [chemical binding]; other site 645463006967 Domain of unknown function (DUF303); Region: DUF303; pfam03629 645463006968 Domain of unknown function (DUF386); Region: DUF386; cl01047 645463006969 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 645463006970 Na binding site [ion binding]; other site 645463006971 N-acetylneuraminate lyase; Provisional; Region: PRK04147 645463006972 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 645463006973 inhibitor site; inhibition site 645463006974 active site 645463006975 dimer interface [polypeptide binding]; other site 645463006976 catalytic residue [active] 645463006977 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 645463006978 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 645463006979 putative active site cavity [active] 645463006980 Double zinc ribbon; Region: DZR; pfam12773 645463006981 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 645463006982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463006983 metal binding site [ion binding]; metal-binding site 645463006984 active site 645463006985 I-site; other site 645463006986 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 645463006987 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 645463006988 putative dimer interface [polypeptide binding]; other site 645463006989 putative anticodon binding site; other site 645463006990 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 645463006991 homodimer interface [polypeptide binding]; other site 645463006992 motif 1; other site 645463006993 motif 2; other site 645463006994 active site 645463006995 motif 3; other site 645463006996 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 645463006997 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 645463006998 active site 645463006999 catalytic triad [active] 645463007000 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 645463007001 active site 645463007002 catalytic triad [active] 645463007003 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 645463007004 active site 645463007005 catalytic triad [active] 645463007006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 645463007007 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463007008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463007009 Walker A motif; other site 645463007010 ATP binding site [chemical binding]; other site 645463007011 Walker B motif; other site 645463007012 arginine finger; other site 645463007013 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645463007014 Domain of unknown function DUF20; Region: UPF0118; pfam01594 645463007015 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 645463007016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463007017 FeS/SAM binding site; other site 645463007018 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 645463007019 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645463007020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463007021 DNA-binding site [nucleotide binding]; DNA binding site 645463007022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007024 homodimer interface [polypeptide binding]; other site 645463007025 catalytic residue [active] 645463007026 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 645463007027 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 645463007028 Cupin domain; Region: Cupin_2; pfam07883 645463007029 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463007030 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645463007031 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463007032 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 645463007033 active site 645463007034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463007035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463007036 putative substrate translocation pore; other site 645463007037 POT family; Region: PTR2; cl17359 645463007038 SurA N-terminal domain; Region: SurA_N_3; cl07813 645463007039 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 645463007040 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 645463007041 FAD dependent oxidoreductase; Region: DAO; pfam01266 645463007042 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 645463007043 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 645463007044 [2Fe-2S] cluster binding site [ion binding]; other site 645463007045 CAAX protease self-immunity; Region: Abi; pfam02517 645463007046 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 645463007047 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007048 active site 645463007049 phosphorylation site [posttranslational modification] 645463007050 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463007051 active site 645463007052 P-loop; other site 645463007053 phosphorylation site [posttranslational modification] 645463007054 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463007055 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 645463007056 putative substrate binding site [chemical binding]; other site 645463007057 putative ATP binding site [chemical binding]; other site 645463007058 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463007059 HTH domain; Region: HTH_11; pfam08279 645463007060 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463007061 PRD domain; Region: PRD; pfam00874 645463007062 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463007063 active site 645463007064 P-loop; other site 645463007065 phosphorylation site [posttranslational modification] 645463007066 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007067 active site 645463007068 phosphorylation site [posttranslational modification] 645463007069 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 645463007070 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 645463007071 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 645463007072 Domain of unknown function DUF20; Region: UPF0118; cl00465 645463007073 DNA topoisomerase III; Provisional; Region: PRK07726 645463007074 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 645463007075 active site 645463007076 putative interdomain interaction site [polypeptide binding]; other site 645463007077 putative metal-binding site [ion binding]; other site 645463007078 putative nucleotide binding site [chemical binding]; other site 645463007079 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645463007080 domain I; other site 645463007081 DNA binding groove [nucleotide binding] 645463007082 phosphate binding site [ion binding]; other site 645463007083 domain II; other site 645463007084 domain III; other site 645463007085 nucleotide binding site [chemical binding]; other site 645463007086 catalytic site [active] 645463007087 domain IV; other site 645463007088 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 645463007089 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 645463007090 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645463007091 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 645463007092 intersubunit interface [polypeptide binding]; other site 645463007093 active site 645463007094 Zn2+ binding site [ion binding]; other site 645463007095 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 645463007096 intersubunit interface [polypeptide binding]; other site 645463007097 active site 645463007098 Zn2+ binding site [ion binding]; other site 645463007099 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645463007100 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 645463007101 putative NAD(P) binding site [chemical binding]; other site 645463007102 catalytic Zn binding site [ion binding]; other site 645463007103 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 645463007104 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 645463007105 active site 645463007106 P-loop; other site 645463007107 phosphorylation site [posttranslational modification] 645463007108 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007109 active site 645463007110 phosphorylation site [posttranslational modification] 645463007111 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 645463007112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463007113 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463007114 Walker A motif; other site 645463007115 ATP binding site [chemical binding]; other site 645463007116 Walker B motif; other site 645463007117 arginine finger; other site 645463007118 PRD domain; Region: PRD; pfam00874 645463007119 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463007120 active pocket/dimerization site; other site 645463007121 active site 645463007122 phosphorylation site [posttranslational modification] 645463007123 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463007124 active site 645463007125 phosphorylation site [posttranslational modification] 645463007126 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 645463007127 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463007128 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645463007129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463007130 DNA-binding site [nucleotide binding]; DNA binding site 645463007131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007133 homodimer interface [polypeptide binding]; other site 645463007134 catalytic residue [active] 645463007135 AzlC protein; Region: AzlC; pfam03591 645463007136 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 645463007137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463007138 HAMP domain; Region: HAMP; pfam00672 645463007139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463007140 dimer interface [polypeptide binding]; other site 645463007141 phosphorylation site [posttranslational modification] 645463007142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463007143 ATP binding site [chemical binding]; other site 645463007144 Mg2+ binding site [ion binding]; other site 645463007145 G-X-G motif; other site 645463007146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463007147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463007148 active site 645463007149 phosphorylation site [posttranslational modification] 645463007150 intermolecular recognition site; other site 645463007151 dimerization interface [polypeptide binding]; other site 645463007152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463007153 DNA binding site [nucleotide binding] 645463007154 Penicillinase repressor; Region: Pencillinase_R; cl17580 645463007155 Penicillinase repressor; Region: Penicillinase_R; cl17580 645463007156 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 645463007157 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 645463007158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463007159 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 645463007160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463007161 non-specific DNA binding site [nucleotide binding]; other site 645463007162 salt bridge; other site 645463007163 sequence-specific DNA binding site [nucleotide binding]; other site 645463007164 putative transposase OrfB; Reviewed; Region: PHA02517 645463007165 HTH-like domain; Region: HTH_21; pfam13276 645463007166 Integrase core domain; Region: rve; pfam00665 645463007167 Integrase core domain; Region: rve_2; pfam13333 645463007168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463007169 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463007170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 645463007171 Transposase; Region: HTH_Tnp_1; cl17663 645463007172 Helix-turn-helix domain; Region: HTH_28; pfam13518 645463007173 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 645463007174 DNA-binding site [nucleotide binding]; DNA binding site 645463007175 RNA-binding motif; other site 645463007176 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 645463007177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463007178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463007179 substrate binding pocket [chemical binding]; other site 645463007180 membrane-bound complex binding site; other site 645463007181 hinge residues; other site 645463007182 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 645463007183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463007184 dimer interface [polypeptide binding]; other site 645463007185 conserved gate region; other site 645463007186 putative PBP binding loops; other site 645463007187 ABC-ATPase subunit interface; other site 645463007188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463007189 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 645463007190 Walker A/P-loop; other site 645463007191 ATP binding site [chemical binding]; other site 645463007192 Q-loop/lid; other site 645463007193 ABC transporter signature motif; other site 645463007194 Walker B; other site 645463007195 D-loop; other site 645463007196 H-loop/switch region; other site 645463007197 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 645463007198 Domain of unknown function (DUF364); Region: DUF364; pfam04016 645463007199 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 645463007200 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463007201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463007202 active site 645463007203 phosphorylation site [posttranslational modification] 645463007204 intermolecular recognition site; other site 645463007205 dimerization interface [polypeptide binding]; other site 645463007206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463007207 DNA binding site [nucleotide binding] 645463007208 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 645463007209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463007210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463007211 dimerization interface [polypeptide binding]; other site 645463007212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463007213 dimer interface [polypeptide binding]; other site 645463007214 phosphorylation site [posttranslational modification] 645463007215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463007216 ATP binding site [chemical binding]; other site 645463007217 Mg2+ binding site [ion binding]; other site 645463007218 G-X-G motif; other site 645463007219 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 645463007220 active site 645463007221 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 645463007222 substrate binding site [chemical binding]; other site 645463007223 metal binding site [ion binding]; metal-binding site 645463007224 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 645463007225 substrate binding site [chemical binding]; other site 645463007226 hexamer interface [polypeptide binding]; other site 645463007227 metal binding site [ion binding]; metal-binding site 645463007228 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 645463007229 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 645463007230 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645463007231 PYR/PP interface [polypeptide binding]; other site 645463007232 dimer interface [polypeptide binding]; other site 645463007233 TPP binding site [chemical binding]; other site 645463007234 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463007235 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 645463007236 TPP-binding site [chemical binding]; other site 645463007237 dimer interface [polypeptide binding]; other site 645463007238 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645463007239 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 645463007240 putative NAD(P) binding site [chemical binding]; other site 645463007241 catalytic Zn binding site [ion binding]; other site 645463007242 structural Zn binding site [ion binding]; other site 645463007243 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 645463007244 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 645463007245 putative NAD(P) binding site [chemical binding]; other site 645463007246 catalytic Zn binding site [ion binding]; other site 645463007247 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 645463007248 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 645463007249 active site 645463007250 P-loop; other site 645463007251 phosphorylation site [posttranslational modification] 645463007252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007253 active site 645463007254 phosphorylation site [posttranslational modification] 645463007255 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 645463007256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463007257 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463007258 Walker A motif; other site 645463007259 ATP binding site [chemical binding]; other site 645463007260 Walker B motif; other site 645463007261 arginine finger; other site 645463007262 PRD domain; Region: PRD; pfam00874 645463007263 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463007264 active pocket/dimerization site; other site 645463007265 active site 645463007266 phosphorylation site [posttranslational modification] 645463007267 PTS system, Lactose/Cellobiose specific IIB subunit; Region: PTS_IIB; pfam02302 645463007268 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007269 active site 645463007270 phosphorylation site [posttranslational modification] 645463007271 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 645463007272 active site 645463007273 intersubunit interactions; other site 645463007274 catalytic residue [active] 645463007275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463007276 active site 645463007277 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 645463007278 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 645463007279 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 645463007280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007281 active site 645463007282 phosphorylation site [posttranslational modification] 645463007283 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463007284 HTH domain; Region: HTH_11; cl17392 645463007285 PRD domain; Region: PRD; pfam00874 645463007286 PRD domain; Region: PRD; pfam00874 645463007287 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463007288 active site 645463007289 P-loop; other site 645463007290 phosphorylation site [posttranslational modification] 645463007291 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 645463007292 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 645463007293 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 645463007294 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 645463007295 active site 645463007296 P-loop; other site 645463007297 phosphorylation site [posttranslational modification] 645463007298 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 645463007299 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 645463007300 active site 645463007301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 645463007302 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 645463007303 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 645463007304 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 645463007305 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 645463007306 active site 645463007307 NAD binding site [chemical binding]; other site 645463007308 metal binding site [ion binding]; metal-binding site 645463007309 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 645463007310 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 645463007311 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 645463007312 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 645463007313 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 645463007314 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 645463007315 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 645463007316 putative catalytic cysteine [active] 645463007317 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 645463007318 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 645463007319 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 645463007320 Predicted permease [General function prediction only]; Region: COG2985 645463007321 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 645463007322 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 645463007323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463007324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463007325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645463007326 dimerization interface [polypeptide binding]; other site 645463007327 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645463007328 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463007329 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645463007330 active site 645463007331 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 645463007332 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 645463007333 dimer interface [polypeptide binding]; other site 645463007334 active site 645463007335 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355 645463007336 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 645463007337 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 645463007338 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645463007339 catalytic residues [active] 645463007340 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 645463007341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463007342 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 645463007343 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 645463007344 active site 645463007345 Zn binding site [ion binding]; other site 645463007346 sugar phosphate phosphatase; Provisional; Region: PRK10513 645463007347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463007348 active site 645463007349 motif I; other site 645463007350 motif II; other site 645463007351 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463007352 Alkylmercury lyase; Region: MerB; pfam03243 645463007353 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645463007354 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 645463007355 Walker A/P-loop; other site 645463007356 ATP binding site [chemical binding]; other site 645463007357 Q-loop/lid; other site 645463007358 ABC transporter signature motif; other site 645463007359 Walker B; other site 645463007360 D-loop; other site 645463007361 H-loop/switch region; other site 645463007362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463007363 substrate binding pocket [chemical binding]; other site 645463007364 membrane-bound complex binding site; other site 645463007365 hinge residues; other site 645463007366 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 645463007367 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 645463007368 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 645463007369 Predicted permeases [General function prediction only]; Region: COG0701 645463007370 DsrE/DsrF-like family; Region: DrsE; cl00672 645463007371 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 645463007372 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 645463007373 dimerization interface [polypeptide binding]; other site 645463007374 active site 645463007375 L-aspartate oxidase; Provisional; Region: PRK06175 645463007376 FAD binding domain; Region: FAD_binding_2; pfam00890 645463007377 Quinolinate synthetase A protein; Region: NadA; pfam02445 645463007378 Carbon starvation protein CstA; Region: CstA; pfam02554 645463007379 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 645463007380 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 645463007381 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 645463007382 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 645463007383 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 645463007384 nudix motif; other site 645463007385 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463007386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463007387 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463007388 butyrate kinase; Provisional; Region: PRK03011 645463007389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463007390 nucleotide binding site [chemical binding]; other site 645463007391 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 645463007392 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 645463007393 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 645463007394 dimer interface [polypeptide binding]; other site 645463007395 PYR/PP interface [polypeptide binding]; other site 645463007396 TPP binding site [chemical binding]; other site 645463007397 substrate binding site [chemical binding]; other site 645463007398 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 645463007399 TPP-binding site; other site 645463007400 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463007401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007402 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 645463007403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007404 homodimer interface [polypeptide binding]; other site 645463007405 catalytic residue [active] 645463007406 Propionate catabolism activator; Region: PrpR_N; pfam06506 645463007407 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 645463007408 PAS domain; Region: PAS; smart00091 645463007409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463007410 Walker A motif; other site 645463007411 ATP binding site [chemical binding]; other site 645463007412 Walker B motif; other site 645463007413 arginine finger; other site 645463007414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463007415 metal binding site [ion binding]; metal-binding site 645463007416 active site 645463007417 I-site; other site 645463007418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463007419 metal binding site [ion binding]; metal-binding site 645463007420 active site 645463007421 I-site; other site 645463007422 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 645463007423 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 645463007424 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 645463007425 active site 645463007426 FMN binding site [chemical binding]; other site 645463007427 substrate binding site [chemical binding]; other site 645463007428 putative catalytic residues [active] 645463007429 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463007430 Penicillinase repressor; Region: Pencillinase_R; pfam03965 645463007431 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 645463007432 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 645463007433 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 645463007434 Penicillinase repressor; Region: Pencillinase_R; pfam03965 645463007435 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 645463007436 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 645463007437 Transglycosylase; Region: Transgly; pfam00912 645463007438 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 645463007439 active site 645463007440 catalytic site [active] 645463007441 substrate binding site [chemical binding]; other site 645463007442 MORN repeat; Region: MORN; cl14787 645463007443 Flavin Reductases; Region: FlaRed; cl00801 645463007444 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 645463007445 active site 645463007446 catalytic site [active] 645463007447 substrate binding site [chemical binding]; other site 645463007448 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 645463007449 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 645463007450 Ligand Binding Site [chemical binding]; other site 645463007451 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 645463007452 CotJB protein; Region: CotJB; pfam12652 645463007453 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 645463007454 dinuclear metal binding motif [ion binding]; other site 645463007455 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463007456 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463007457 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463007458 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645463007459 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463007460 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 645463007461 trimer interface [polypeptide binding]; other site 645463007462 active site 645463007463 DNA topoisomerase III; Provisional; Region: PRK07726 645463007464 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 645463007465 active site 645463007466 putative interdomain interaction site [polypeptide binding]; other site 645463007467 putative metal-binding site [ion binding]; other site 645463007468 putative nucleotide binding site [chemical binding]; other site 645463007469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 645463007470 domain I; other site 645463007471 DNA binding groove [nucleotide binding] 645463007472 phosphate binding site [ion binding]; other site 645463007473 domain II; other site 645463007474 domain III; other site 645463007475 nucleotide binding site [chemical binding]; other site 645463007476 catalytic site [active] 645463007477 domain IV; other site 645463007478 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 645463007479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463007480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463007481 dimerization interface [polypeptide binding]; other site 645463007482 putative Zn2+ binding site [ion binding]; other site 645463007483 putative DNA binding site [nucleotide binding]; other site 645463007484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 645463007485 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 645463007486 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 645463007487 HlyD family secretion protein; Region: HlyD_3; pfam13437 645463007488 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 645463007489 MMPL family; Region: MMPL; cl14618 645463007490 MMPL family; Region: MMPL; cl14618 645463007491 Outer membrane efflux protein; Region: OEP; pfam02321 645463007492 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 645463007493 HTH-like domain; Region: HTH_21; pfam13276 645463007494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 645463007495 Integrase core domain; Region: rve; pfam00665 645463007496 Integrase core domain; Region: rve_2; pfam13333 645463007497 DNA polymerase II large subunit; Validated; Region: PRK04023 645463007498 pyruvate phosphate dikinase; Provisional; Region: PRK09279 645463007499 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 645463007500 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645463007501 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 645463007502 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 645463007503 HTH domain; Region: HTH_11; pfam08279 645463007504 FOG: CBS domain [General function prediction only]; Region: COG0517 645463007505 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 645463007506 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 645463007507 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 645463007508 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 645463007509 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 645463007510 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463007511 HTH domain; Region: HTH_11; pfam08279 645463007512 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463007513 PRD domain; Region: PRD; pfam00874 645463007514 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463007515 active site 645463007516 P-loop; other site 645463007517 phosphorylation site [posttranslational modification] 645463007518 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463007519 active site 645463007520 phosphorylation site [posttranslational modification] 645463007521 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 645463007522 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 645463007523 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 645463007524 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 645463007525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463007526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463007527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463007528 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463007529 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 645463007530 active site 645463007531 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463007532 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 645463007533 metal binding site [ion binding]; metal-binding site 645463007534 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 645463007535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463007536 putative substrate translocation pore; other site 645463007537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463007538 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 645463007539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007541 homodimer interface [polypeptide binding]; other site 645463007542 catalytic residue [active] 645463007543 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 645463007544 butyrate kinase; Provisional; Region: PRK03011 645463007545 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 645463007546 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 645463007547 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 645463007548 TPP-binding site [chemical binding]; other site 645463007549 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 645463007550 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 645463007551 dimer interface [polypeptide binding]; other site 645463007552 PYR/PP interface [polypeptide binding]; other site 645463007553 TPP binding site [chemical binding]; other site 645463007554 substrate binding site [chemical binding]; other site 645463007555 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463007556 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463007557 Transcriptional regulator [Transcription]; Region: IclR; COG1414 645463007558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463007559 putative DNA binding site [nucleotide binding]; other site 645463007560 putative Zn2+ binding site [ion binding]; other site 645463007561 Bacterial transcriptional regulator; Region: IclR; pfam01614 645463007562 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 645463007563 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645463007564 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 645463007565 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 645463007566 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463007567 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 645463007568 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 645463007569 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 645463007570 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 645463007571 dimer interface [polypeptide binding]; other site 645463007572 motif 1; other site 645463007573 active site 645463007574 motif 2; other site 645463007575 motif 3; other site 645463007576 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 645463007577 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 645463007578 Recombination protein O N terminal; Region: RecO_N; pfam11967 645463007579 Recombination protein O C terminal; Region: RecO_C; pfam02565 645463007580 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 645463007581 MgtE intracellular N domain; Region: MgtE_N; pfam03448 645463007582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 645463007583 Divalent cation transporter; Region: MgtE; cl00786 645463007584 GTPase Era; Reviewed; Region: era; PRK00089 645463007585 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 645463007586 G1 box; other site 645463007587 GTP/Mg2+ binding site [chemical binding]; other site 645463007588 Switch I region; other site 645463007589 G2 box; other site 645463007590 Switch II region; other site 645463007591 G3 box; other site 645463007592 G4 box; other site 645463007593 G5 box; other site 645463007594 KH domain; Region: KH_2; pfam07650 645463007595 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 645463007596 active site 645463007597 catalytic motif [active] 645463007598 Zn binding site [ion binding]; other site 645463007599 Integral membrane undecaprenol kinase domain co-occurring with type 2 phosphatidic acid phosphatase-like domains; Region: UDPK_IM_PAP2_like; cd14266 645463007600 trimer interface [polypeptide binding]; other site 645463007601 putative active site [active] 645463007602 Zn binding site [ion binding]; other site 645463007603 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 645463007604 active site 645463007605 metal-binding heat shock protein; Provisional; Region: PRK00016 645463007606 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 645463007607 PhoH-like protein; Region: PhoH; pfam02562 645463007608 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 645463007609 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 645463007610 YabP family; Region: YabP; pfam07873 645463007611 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 645463007612 30S subunit binding site; other site 645463007613 TspO/MBR family; Region: TspO_MBR; pfam03073 645463007614 Yqey-like protein; Region: YqeY; pfam09424 645463007615 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 645463007616 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 645463007617 nucleotide binding site/active site [active] 645463007618 HIT family signature motif; other site 645463007619 catalytic residue [active] 645463007620 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 645463007621 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 645463007622 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463007623 FeS/SAM binding site; other site 645463007624 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 645463007625 RNA methyltransferase, RsmE family; Region: TIGR00046 645463007626 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 645463007627 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 645463007628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463007629 S-adenosylmethionine binding site [chemical binding]; other site 645463007630 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 645463007631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 645463007632 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 645463007633 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 645463007634 ATP binding site [chemical binding]; other site 645463007635 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cd09658 645463007636 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 645463007637 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 645463007638 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 645463007639 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 645463007640 Walker A/P-loop; other site 645463007641 ATP binding site [chemical binding]; other site 645463007642 Q-loop/lid; other site 645463007643 ABC transporter signature motif; other site 645463007644 Walker B; other site 645463007645 D-loop; other site 645463007646 H-loop/switch region; other site 645463007647 TOBE domain; Region: TOBE_2; pfam08402 645463007648 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 645463007649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463007650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463007651 putative substrate translocation pore; other site 645463007652 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463007653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463007654 nucleotide binding site [chemical binding]; other site 645463007655 chaperone protein DnaJ; Provisional; Region: PRK10767 645463007656 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 645463007657 HSP70 interaction site [polypeptide binding]; other site 645463007658 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 645463007659 substrate binding site [polypeptide binding]; other site 645463007660 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 645463007661 Zn binding sites [ion binding]; other site 645463007662 dimer interface [polypeptide binding]; other site 645463007663 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 645463007664 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 645463007665 nucleotide binding site [chemical binding]; other site 645463007666 NEF interaction site [polypeptide binding]; other site 645463007667 SBD interface [polypeptide binding]; other site 645463007668 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 645463007669 GrpE; Region: GrpE; pfam01025 645463007670 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 645463007671 dimer interface [polypeptide binding]; other site 645463007672 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 645463007673 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 645463007674 HrcA protein C terminal domain; Region: HrcA; pfam01628 645463007675 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 645463007676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463007677 FeS/SAM binding site; other site 645463007678 HemN C-terminal domain; Region: HemN_C; pfam06969 645463007679 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 645463007680 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463007681 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 645463007682 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 645463007683 active site 645463007684 NTP binding site [chemical binding]; other site 645463007685 metal binding triad [ion binding]; metal-binding site 645463007686 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 645463007687 HD domain; Region: HD; pfam01966 645463007688 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 645463007689 GTP-binding protein LepA; Provisional; Region: PRK05433 645463007690 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 645463007691 G1 box; other site 645463007692 putative GEF interaction site [polypeptide binding]; other site 645463007693 GTP/Mg2+ binding site [chemical binding]; other site 645463007694 Switch I region; other site 645463007695 G2 box; other site 645463007696 G3 box; other site 645463007697 Switch II region; other site 645463007698 G4 box; other site 645463007699 G5 box; other site 645463007700 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 645463007701 Elongation Factor G, domain II; Region: EFG_II; pfam14492 645463007702 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 645463007703 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 645463007704 stage II sporulation protein P; Region: spore_II_P; TIGR02867 645463007705 germination protease; Provisional; Region: PRK12362 645463007706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463007707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463007708 dimerization interface [polypeptide binding]; other site 645463007709 putative DNA binding site [nucleotide binding]; other site 645463007710 putative Zn2+ binding site [ion binding]; other site 645463007711 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 645463007712 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 645463007713 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 645463007714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 645463007715 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 645463007716 Sterol carrier protein domain; Region: SCP2_2; pfam13530 645463007717 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 645463007718 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 645463007719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 645463007720 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 645463007721 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 645463007722 putative ATP binding site [chemical binding]; other site 645463007723 putative substrate interface [chemical binding]; other site 645463007724 Domain of unknown function (DUF348); Region: DUF348; pfam03990 645463007725 G5 domain; Region: G5; pfam07501 645463007726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 645463007727 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 645463007728 ligand binding site [chemical binding]; other site 645463007729 active site 645463007730 UGI interface [polypeptide binding]; other site 645463007731 catalytic site [active] 645463007732 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 645463007733 trimer interface [polypeptide binding]; other site 645463007734 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 645463007735 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463007736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007738 homodimer interface [polypeptide binding]; other site 645463007739 catalytic residue [active] 645463007740 aminopeptidase; Provisional; Region: PRK09795 645463007741 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463007742 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645463007743 active site 645463007744 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463007745 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463007746 active site 645463007747 P-loop; other site 645463007748 phosphorylation site [posttranslational modification] 645463007749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007750 active site 645463007751 phosphorylation site [posttranslational modification] 645463007752 putative frv operon regulatory protein; Provisional; Region: PRK09863 645463007753 HTH domain; Region: HTH_11; pfam08279 645463007754 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463007755 PRD domain; Region: PRD; pfam00874 645463007756 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463007757 active site 645463007758 P-loop; other site 645463007759 phosphorylation site [posttranslational modification] 645463007760 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007761 active site 645463007762 phosphorylation site [posttranslational modification] 645463007763 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645463007764 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 645463007765 active site 645463007766 metal binding site [ion binding]; metal-binding site 645463007767 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 645463007768 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 645463007769 PAS domain S-box; Region: sensory_box; TIGR00229 645463007770 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645463007771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463007772 dimer interface [polypeptide binding]; other site 645463007773 phosphorylation site [posttranslational modification] 645463007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463007775 ATP binding site [chemical binding]; other site 645463007776 Mg2+ binding site [ion binding]; other site 645463007777 G-X-G motif; other site 645463007778 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 645463007779 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 645463007780 G1 box; other site 645463007781 putative GEF interaction site [polypeptide binding]; other site 645463007782 GTP/Mg2+ binding site [chemical binding]; other site 645463007783 Switch I region; other site 645463007784 G2 box; other site 645463007785 G3 box; other site 645463007786 Switch II region; other site 645463007787 G4 box; other site 645463007788 G5 box; other site 645463007789 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 645463007790 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 645463007791 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 645463007792 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 645463007793 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 645463007794 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 645463007795 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 645463007796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463007797 catalytic residue [active] 645463007798 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 645463007799 dimerization interface [polypeptide binding]; other site 645463007800 putative ATP binding site [chemical binding]; other site 645463007801 SLBB domain; Region: SLBB; pfam10531 645463007802 comEA protein; Region: comE; TIGR01259 645463007803 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 645463007804 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 645463007805 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 645463007806 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 645463007807 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 645463007808 argininosuccinate lyase; Provisional; Region: PRK00855 645463007809 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 645463007810 active sites [active] 645463007811 tetramer interface [polypeptide binding]; other site 645463007812 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645463007813 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463007814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463007815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007816 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 645463007817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007818 homodimer interface [polypeptide binding]; other site 645463007819 catalytic residue [active] 645463007820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645463007821 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645463007822 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463007823 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 645463007824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463007825 motif II; other site 645463007826 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645463007827 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 645463007828 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 645463007829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463007830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463007831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463007832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463007833 putative substrate translocation pore; other site 645463007834 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 645463007835 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 645463007836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463007837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463007838 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 645463007839 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645463007840 NAD(P) binding site [chemical binding]; other site 645463007841 LDH/MDH dimer interface [polypeptide binding]; other site 645463007842 substrate binding site [chemical binding]; other site 645463007843 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 645463007844 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463007845 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463007846 active site turn [active] 645463007847 phosphorylation site [posttranslational modification] 645463007848 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463007849 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463007850 PRD domain; Region: PRD; pfam00874 645463007851 PRD domain; Region: PRD; pfam00874 645463007852 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463007853 HPr interaction site; other site 645463007854 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463007855 active site 645463007856 phosphorylation site [posttranslational modification] 645463007857 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 645463007858 homotrimer interaction site [polypeptide binding]; other site 645463007859 putative active site [active] 645463007860 threonine dehydratase; Provisional; Region: PRK08198 645463007861 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 645463007862 tetramer interface [polypeptide binding]; other site 645463007863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007864 catalytic residue [active] 645463007865 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 645463007866 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 645463007867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463007868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463007869 homodimer interface [polypeptide binding]; other site 645463007870 catalytic residue [active] 645463007871 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 645463007872 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 645463007873 active site 645463007874 homotetramer interface [polypeptide binding]; other site 645463007875 homodimer interface [polypeptide binding]; other site 645463007876 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 645463007877 VanZ like family; Region: VanZ; pfam04892 645463007878 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 645463007879 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 645463007880 active site 645463007881 HIGH motif; other site 645463007882 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645463007883 KMSKS motif; other site 645463007884 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 645463007885 tRNA binding surface [nucleotide binding]; other site 645463007886 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 645463007887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645463007888 Zn2+ binding site [ion binding]; other site 645463007889 Mg2+ binding site [ion binding]; other site 645463007890 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 645463007891 active site 645463007892 (T/H)XGH motif; other site 645463007893 glycogen branching enzyme; Provisional; Region: PRK12313 645463007894 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 645463007895 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 645463007896 active site 645463007897 catalytic site [active] 645463007898 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 645463007899 Helix-turn-helix domain; Region: HTH_18; pfam12833 645463007900 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 645463007901 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 645463007902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463007903 catalytic residue [active] 645463007904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463007905 FtsX-like permease family; Region: FtsX; pfam02687 645463007906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463007907 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463007908 FtsX-like permease family; Region: FtsX; pfam02687 645463007909 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463007910 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463007911 Walker A/P-loop; other site 645463007912 ATP binding site [chemical binding]; other site 645463007913 Q-loop/lid; other site 645463007914 ABC transporter signature motif; other site 645463007915 Walker B; other site 645463007916 D-loop; other site 645463007917 H-loop/switch region; other site 645463007918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463007919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463007920 dimer interface [polypeptide binding]; other site 645463007921 phosphorylation site [posttranslational modification] 645463007922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463007923 ATP binding site [chemical binding]; other site 645463007924 Mg2+ binding site [ion binding]; other site 645463007925 G-X-G motif; other site 645463007926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463007927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463007928 active site 645463007929 phosphorylation site [posttranslational modification] 645463007930 intermolecular recognition site; other site 645463007931 dimerization interface [polypeptide binding]; other site 645463007932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463007933 DNA binding site [nucleotide binding] 645463007934 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 645463007935 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 645463007936 putative active site [active] 645463007937 putative metal binding site [ion binding]; other site 645463007938 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 645463007939 ribonuclease Z; Reviewed; Region: PRK00055 645463007940 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 645463007941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463007942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463007943 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 645463007944 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 645463007945 DHHW protein; Region: DHHW; pfam14286 645463007946 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 645463007947 Phosphate transport (Pho88); Region: Pho88; cl02110 645463007948 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 645463007949 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 645463007950 DXD motif; other site 645463007951 PilZ domain; Region: PilZ; pfam07238 645463007952 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 645463007953 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 645463007954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645463007955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463007956 dimer interface [polypeptide binding]; other site 645463007957 conserved gate region; other site 645463007958 putative PBP binding loops; other site 645463007959 ABC-ATPase subunit interface; other site 645463007960 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 645463007961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463007962 dimer interface [polypeptide binding]; other site 645463007963 conserved gate region; other site 645463007964 putative PBP binding loops; other site 645463007965 ABC-ATPase subunit interface; other site 645463007966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645463007967 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 645463007968 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463007969 putative active site [active] 645463007970 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 645463007971 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 645463007972 active site 645463007973 P-loop; other site 645463007974 phosphorylation site [posttranslational modification] 645463007975 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463007976 HTH domain; Region: HTH_11; pfam08279 645463007977 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463007978 PRD domain; Region: PRD; pfam00874 645463007979 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463007980 active site 645463007981 P-loop; other site 645463007982 phosphorylation site [posttranslational modification] 645463007983 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463007984 active site 645463007985 phosphorylation site [posttranslational modification] 645463007986 hypothetical protein; Region: PHA00671 645463007987 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 645463007988 active site 645463007989 (T/H)XGH motif; other site 645463007990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463007991 S-adenosylmethionine binding site [chemical binding]; other site 645463007992 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 645463007993 Y-family of DNA polymerases; Region: PolY; cl12025 645463007994 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 645463007995 generic binding surface II; other site 645463007996 ssDNA binding site; other site 645463007997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463007998 ATP binding site [chemical binding]; other site 645463007999 putative Mg++ binding site [ion binding]; other site 645463008000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463008001 nucleotide binding region [chemical binding]; other site 645463008002 ATP-binding site [chemical binding]; other site 645463008003 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 645463008004 DAK2 domain; Region: Dak2; pfam02734 645463008005 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 645463008006 Asp23 family; Region: Asp23; pfam03780 645463008007 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 645463008008 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 645463008009 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 645463008010 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463008011 DNA binding residues [nucleotide binding] 645463008012 dimer interface [polypeptide binding]; other site 645463008013 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 645463008014 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463008015 HTH domain; Region: HTH_11; pfam08279 645463008016 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463008017 PRD domain; Region: PRD; pfam00874 645463008018 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463008019 active site 645463008020 P-loop; other site 645463008021 phosphorylation site [posttranslational modification] 645463008022 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463008023 active site 645463008024 phosphorylation site [posttranslational modification] 645463008025 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463008026 active site 645463008027 phosphorylation site [posttranslational modification] 645463008028 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463008029 active site 645463008030 P-loop; other site 645463008031 phosphorylation site [posttranslational modification] 645463008032 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463008033 alpha-mannosidase; Provisional; Region: PRK09819 645463008034 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 645463008035 active site 645463008036 metal binding site [ion binding]; metal-binding site 645463008037 catalytic site [active] 645463008038 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 645463008039 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 645463008040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463008041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463008042 dimer interface [polypeptide binding]; other site 645463008043 phosphorylation site [posttranslational modification] 645463008044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463008045 ATP binding site [chemical binding]; other site 645463008046 Mg2+ binding site [ion binding]; other site 645463008047 G-X-G motif; other site 645463008048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463008049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463008050 active site 645463008051 phosphorylation site [posttranslational modification] 645463008052 intermolecular recognition site; other site 645463008053 dimerization interface [polypeptide binding]; other site 645463008054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463008055 DNA binding site [nucleotide binding] 645463008056 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463008057 FMN binding site [chemical binding]; other site 645463008058 dimer interface [polypeptide binding]; other site 645463008059 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 645463008060 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463008061 Thiamine pyrophosphokinase; Region: TPK; cd07995 645463008062 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 645463008063 active site 645463008064 dimerization interface [polypeptide binding]; other site 645463008065 thiamine binding site [chemical binding]; other site 645463008066 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 645463008067 substrate binding site [chemical binding]; other site 645463008068 hexamer interface [polypeptide binding]; other site 645463008069 metal binding site [ion binding]; metal-binding site 645463008070 GTPase RsgA; Reviewed; Region: PRK00098 645463008071 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 645463008072 RNA binding site [nucleotide binding]; other site 645463008073 homodimer interface [polypeptide binding]; other site 645463008074 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 645463008075 GTPase/Zn-binding domain interface [polypeptide binding]; other site 645463008076 GTP/Mg2+ binding site [chemical binding]; other site 645463008077 G4 box; other site 645463008078 G5 box; other site 645463008079 G1 box; other site 645463008080 Switch I region; other site 645463008081 G2 box; other site 645463008082 G3 box; other site 645463008083 Switch II region; other site 645463008084 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 645463008085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645463008086 NAD(P) binding site [chemical binding]; other site 645463008087 active site 645463008088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 645463008089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 645463008090 active site 645463008091 ATP binding site [chemical binding]; other site 645463008092 substrate binding site [chemical binding]; other site 645463008093 activation loop (A-loop); other site 645463008094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645463008095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 645463008096 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 645463008097 active site 645463008098 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 645463008099 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463008100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463008101 FeS/SAM binding site; other site 645463008102 16S rRNA methyltransferase B; Provisional; Region: PRK14902 645463008103 NusB family; Region: NusB; pfam01029 645463008104 putative RNA binding site [nucleotide binding]; other site 645463008105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463008106 S-adenosylmethionine binding site [chemical binding]; other site 645463008107 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 645463008108 Protein of unknown function DUF116; Region: DUF116; pfam01976 645463008109 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 645463008110 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 645463008111 putative active site [active] 645463008112 substrate binding site [chemical binding]; other site 645463008113 putative cosubstrate binding site; other site 645463008114 catalytic site [active] 645463008115 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 645463008116 substrate binding site [chemical binding]; other site 645463008117 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 645463008118 active site 645463008119 catalytic residues [active] 645463008120 metal binding site [ion binding]; metal-binding site 645463008121 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 645463008122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463008123 ATP binding site [chemical binding]; other site 645463008124 putative Mg++ binding site [ion binding]; other site 645463008125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463008126 nucleotide binding region [chemical binding]; other site 645463008127 ATP-binding site [chemical binding]; other site 645463008128 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 645463008129 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 645463008130 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 645463008131 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 645463008132 Guanylate kinase; Region: Guanylate_kin; pfam00625 645463008133 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 645463008134 catalytic site [active] 645463008135 G-X2-G-X-G-K; other site 645463008136 hypothetical protein; Provisional; Region: PRK11820 645463008137 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 645463008138 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 645463008139 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 645463008140 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645463008141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 645463008142 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 645463008143 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 645463008144 tetramer interface [polypeptide binding]; other site 645463008145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463008146 catalytic residue [active] 645463008147 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 645463008148 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 645463008149 Domain of unknown function (DUF814); Region: DUF814; pfam05670 645463008150 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645463008151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463008152 ABC transporter; Region: ABC_tran_2; pfam12848 645463008153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463008154 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 645463008155 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463008156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463008157 active site 645463008158 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 645463008159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463008160 RNA binding surface [nucleotide binding]; other site 645463008161 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645463008162 active site 645463008163 lipoprotein signal peptidase; Provisional; Region: PRK14768 645463008164 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645463008165 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 645463008166 NodB motif; other site 645463008167 active site 645463008168 catalytic site [active] 645463008169 metal binding site [ion binding]; metal-binding site 645463008170 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 645463008171 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 645463008172 Carbon starvation protein CstA; Region: CstA; pfam02554 645463008173 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 645463008174 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463008176 active site 645463008177 phosphorylation site [posttranslational modification] 645463008178 intermolecular recognition site; other site 645463008179 dimerization interface [polypeptide binding]; other site 645463008180 LytTr DNA-binding domain; Region: LytTR; smart00850 645463008181 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 645463008182 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 645463008183 Histidine kinase; Region: His_kinase; pfam06580 645463008184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463008185 ATP binding site [chemical binding]; other site 645463008186 Mg2+ binding site [ion binding]; other site 645463008187 G-X-G motif; other site 645463008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 645463008189 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463008190 LytTr DNA-binding domain; Region: LytTR; smart00850 645463008191 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 645463008192 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 645463008193 active site 645463008194 conformational flexibility of ligand binding pocket; other site 645463008195 ADP-ribosylating toxin turn-turn motif; other site 645463008196 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 645463008197 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 645463008198 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 645463008199 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 645463008200 active site 645463008201 HIGH motif; other site 645463008202 dimer interface [polypeptide binding]; other site 645463008203 KMSKS motif; other site 645463008204 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 645463008205 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 645463008206 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463008207 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645463008208 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463008209 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645463008210 active site 645463008211 EDD domain protein, DegV family; Region: DegV; TIGR00762 645463008212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463008213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463008214 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463008215 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463008216 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 645463008217 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 645463008218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463008219 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463008220 Probable transposase; Region: OrfB_IS605; pfam01385 645463008221 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463008222 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 645463008223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 645463008224 active site 645463008225 HIGH motif; other site 645463008226 nucleotide binding site [chemical binding]; other site 645463008227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645463008228 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 645463008229 active site 645463008230 KMSKS motif; other site 645463008231 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 645463008232 tRNA binding surface [nucleotide binding]; other site 645463008233 anticodon binding site; other site 645463008234 DivIVA protein; Region: DivIVA; pfam05103 645463008235 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 645463008236 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 645463008237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463008238 RNA binding surface [nucleotide binding]; other site 645463008239 YGGT family; Region: YGGT; pfam02325 645463008240 Protein of unknown function (DUF552); Region: DUF552; cl00775 645463008241 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 645463008242 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463008243 catalytic residue [active] 645463008244 HlyD family secretion protein; Region: HlyD_2; pfam12700 645463008245 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 645463008246 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 645463008247 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 645463008248 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 645463008249 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 645463008250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463008252 putative substrate translocation pore; other site 645463008253 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 645463008254 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463008255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645463008256 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463008257 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 645463008258 active site 645463008259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463008260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463008261 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 645463008262 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 645463008263 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 645463008264 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 645463008265 GTP-binding protein Der; Reviewed; Region: PRK00093 645463008266 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 645463008267 G1 box; other site 645463008268 GTP/Mg2+ binding site [chemical binding]; other site 645463008269 Switch I region; other site 645463008270 G2 box; other site 645463008271 Switch II region; other site 645463008272 G3 box; other site 645463008273 G4 box; other site 645463008274 G5 box; other site 645463008275 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 645463008276 G1 box; other site 645463008277 GTP/Mg2+ binding site [chemical binding]; other site 645463008278 Switch I region; other site 645463008279 G2 box; other site 645463008280 G3 box; other site 645463008281 Switch II region; other site 645463008282 G4 box; other site 645463008283 G5 box; other site 645463008284 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 645463008285 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 645463008286 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 645463008287 Protein of unknown function (DUF512); Region: DUF512; pfam04459 645463008288 YIEGIA protein; Region: YIEGIA; pfam14045 645463008289 YIEGIA protein; Region: YIEGIA; pfam14045 645463008290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463008291 dimerization interface [polypeptide binding]; other site 645463008292 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 645463008293 PAS domain; Region: PAS; smart00091 645463008294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463008295 dimer interface [polypeptide binding]; other site 645463008296 phosphorylation site [posttranslational modification] 645463008297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463008298 ATP binding site [chemical binding]; other site 645463008299 Mg2+ binding site [ion binding]; other site 645463008300 G-X-G motif; other site 645463008301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463008302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463008303 active site 645463008304 phosphorylation site [posttranslational modification] 645463008305 intermolecular recognition site; other site 645463008306 dimerization interface [polypeptide binding]; other site 645463008307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463008308 DNA binding site [nucleotide binding] 645463008309 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 645463008310 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 645463008311 ATP cone domain; Region: ATP-cone; pfam03477 645463008312 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 645463008313 sporulation sigma factor SigG; Reviewed; Region: PRK08215 645463008314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463008315 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 645463008316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463008317 DNA binding residues [nucleotide binding] 645463008318 sporulation sigma factor SigE; Reviewed; Region: PRK08301 645463008319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463008320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463008321 DNA binding residues [nucleotide binding] 645463008322 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 645463008323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 645463008324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 645463008325 cell division protein FtsZ; Validated; Region: PRK09330 645463008326 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 645463008327 nucleotide binding site [chemical binding]; other site 645463008328 SulA interaction site; other site 645463008329 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 645463008330 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 645463008331 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 645463008332 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 645463008333 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 645463008334 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 645463008335 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 645463008336 active site 645463008337 homodimer interface [polypeptide binding]; other site 645463008338 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 645463008339 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 645463008340 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645463008341 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645463008342 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 645463008343 Mg++ binding site [ion binding]; other site 645463008344 putative catalytic motif [active] 645463008345 putative substrate binding site [chemical binding]; other site 645463008346 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 645463008347 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645463008348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645463008349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645463008350 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 645463008351 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 645463008352 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 645463008353 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 645463008354 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 645463008355 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 645463008356 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645463008357 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 645463008358 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645463008359 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 645463008360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 645463008361 GTP-binding protein YchF; Reviewed; Region: PRK09601 645463008362 YchF GTPase; Region: YchF; cd01900 645463008363 G1 box; other site 645463008364 GTP/Mg2+ binding site [chemical binding]; other site 645463008365 Switch I region; other site 645463008366 G2 box; other site 645463008367 Switch II region; other site 645463008368 G3 box; other site 645463008369 G4 box; other site 645463008370 G5 box; other site 645463008371 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 645463008372 Cache domain; Region: Cache_1; pfam02743 645463008373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463008374 metal binding site [ion binding]; metal-binding site 645463008375 active site 645463008376 I-site; other site 645463008377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463008378 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 645463008379 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645463008380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645463008381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645463008382 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645463008383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463008384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463008385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463008386 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463008387 HPr interaction site; other site 645463008388 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463008389 active site 645463008390 phosphorylation site [posttranslational modification] 645463008391 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463008392 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463008393 PRD domain; Region: PRD; pfam00874 645463008394 PRD domain; Region: PRD; pfam00874 645463008395 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 645463008396 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 645463008397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645463008398 Walker A/P-loop; other site 645463008399 ATP binding site [chemical binding]; other site 645463008400 Q-loop/lid; other site 645463008401 ABC transporter signature motif; other site 645463008402 Walker B; other site 645463008403 D-loop; other site 645463008404 H-loop/switch region; other site 645463008405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645463008406 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 645463008407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645463008408 Walker A/P-loop; other site 645463008409 ATP binding site [chemical binding]; other site 645463008410 Q-loop/lid; other site 645463008411 ABC transporter signature motif; other site 645463008412 Walker B; other site 645463008413 D-loop; other site 645463008414 H-loop/switch region; other site 645463008415 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645463008416 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 645463008417 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 645463008418 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 645463008419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463008420 dimer interface [polypeptide binding]; other site 645463008421 conserved gate region; other site 645463008422 putative PBP binding loops; other site 645463008423 ABC-ATPase subunit interface; other site 645463008424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 645463008425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463008426 dimer interface [polypeptide binding]; other site 645463008427 conserved gate region; other site 645463008428 putative PBP binding loops; other site 645463008429 ABC-ATPase subunit interface; other site 645463008430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463008431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463008432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645463008433 dimerization interface [polypeptide binding]; other site 645463008434 putative acyltransferase; Provisional; Region: PRK05790 645463008435 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645463008436 dimer interface [polypeptide binding]; other site 645463008437 active site 645463008438 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 645463008439 Coenzyme A transferase; Region: CoA_trans; cl17247 645463008440 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 645463008441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 645463008442 NAD(P) binding site [chemical binding]; other site 645463008443 active site 645463008444 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 645463008445 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 645463008446 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 645463008447 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 645463008448 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645463008449 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 645463008450 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 645463008451 dimer interface [polypeptide binding]; other site 645463008452 PYR/PP interface [polypeptide binding]; other site 645463008453 TPP binding site [chemical binding]; other site 645463008454 substrate binding site [chemical binding]; other site 645463008455 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 645463008456 Domain of unknown function; Region: EKR; pfam10371 645463008457 4Fe-4S binding domain; Region: Fer4_6; pfam12837 645463008458 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 645463008459 TPP-binding site [chemical binding]; other site 645463008460 dimer interface [polypeptide binding]; other site 645463008461 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 645463008462 Propanediol utilisation protein PduL; Region: PduL; pfam06130 645463008463 Propanediol utilisation protein PduL; Region: PduL; pfam06130 645463008464 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463008465 GAF domain; Region: GAF_2; pfam13185 645463008466 GAF domain; Region: GAF_3; pfam13492 645463008467 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 645463008468 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 645463008469 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645463008470 HI0933-like protein; Region: HI0933_like; pfam03486 645463008471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463008472 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 645463008473 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 645463008474 active site 645463008475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463008476 active site 645463008477 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 645463008478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463008479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463008480 homodimer interface [polypeptide binding]; other site 645463008481 catalytic residue [active] 645463008482 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 645463008483 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 645463008484 asparagine synthetase AsnA; Provisional; Region: PRK05425 645463008485 motif 1; other site 645463008486 dimer interface [polypeptide binding]; other site 645463008487 active site 645463008488 motif 2; other site 645463008489 motif 3; other site 645463008490 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463008491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463008492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463008493 homodimer interface [polypeptide binding]; other site 645463008494 catalytic residue [active] 645463008495 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 645463008496 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463008497 metal binding site [ion binding]; metal-binding site 645463008498 putative dimer interface [polypeptide binding]; other site 645463008499 hypothetical protein; Provisional; Region: PRK10519 645463008500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 645463008501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463008502 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463008503 Walker A motif; other site 645463008504 ATP binding site [chemical binding]; other site 645463008505 Walker B motif; other site 645463008506 arginine finger; other site 645463008507 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 645463008508 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 645463008509 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 645463008510 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 645463008511 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 645463008512 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463008513 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 645463008514 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 645463008515 active site 645463008516 putative substrate binding pocket [chemical binding]; other site 645463008517 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 645463008518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463008519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463008520 putative substrate translocation pore; other site 645463008521 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 645463008522 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 645463008523 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 645463008524 shikimate binding site; other site 645463008525 NAD(P) binding site [chemical binding]; other site 645463008526 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 645463008527 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 645463008528 active site 645463008529 FMN binding site [chemical binding]; other site 645463008530 substrate binding site [chemical binding]; other site 645463008531 putative catalytic residue [active] 645463008532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463008533 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 645463008534 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 645463008535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463008536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463008537 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 645463008538 putative dimerization interface [polypeptide binding]; other site 645463008539 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 645463008540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645463008541 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645463008542 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 645463008543 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 645463008544 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 645463008545 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008546 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008547 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008548 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 645463008549 UDP-glucose 4-epimerase; Region: PLN02240 645463008550 NAD binding site [chemical binding]; other site 645463008551 homodimer interface [polypeptide binding]; other site 645463008552 active site 645463008553 substrate binding site [chemical binding]; other site 645463008554 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645463008555 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645463008556 active site 645463008557 tetramer interface; other site 645463008558 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 645463008559 Sporulation related domain; Region: SPOR; pfam05036 645463008560 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 645463008561 active site 645463008562 catalytic site [active] 645463008563 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 645463008564 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 645463008565 NodB motif; other site 645463008566 active site 645463008567 catalytic site [active] 645463008568 Cd binding site [ion binding]; other site 645463008569 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 645463008570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463008571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463008572 dimerization interface [polypeptide binding]; other site 645463008573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463008574 dimer interface [polypeptide binding]; other site 645463008575 phosphorylation site [posttranslational modification] 645463008576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463008577 ATP binding site [chemical binding]; other site 645463008578 Mg2+ binding site [ion binding]; other site 645463008579 G-X-G motif; other site 645463008580 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463008581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463008582 active site 645463008583 phosphorylation site [posttranslational modification] 645463008584 intermolecular recognition site; other site 645463008585 dimerization interface [polypeptide binding]; other site 645463008586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463008587 DNA binding site [nucleotide binding] 645463008588 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 645463008589 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 645463008590 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 645463008591 NodB motif; other site 645463008592 putative active site [active] 645463008593 putative catalytic site [active] 645463008594 putative Zn binding site [ion binding]; other site 645463008595 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 645463008596 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 645463008597 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 645463008598 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 645463008599 dimer interface [polypeptide binding]; other site 645463008600 active site 645463008601 glycine-pyridoxal phosphate binding site [chemical binding]; other site 645463008602 folate binding site [chemical binding]; other site 645463008603 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 645463008604 Uncharacterized conserved protein [Function unknown]; Region: COG2966 645463008605 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 645463008606 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 645463008607 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 645463008608 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 645463008609 putative homodimer interface [polypeptide binding]; other site 645463008610 putative homotetramer interface [polypeptide binding]; other site 645463008611 putative allosteric switch controlling residues; other site 645463008612 putative metal binding site [ion binding]; other site 645463008613 putative homodimer-homodimer interface [polypeptide binding]; other site 645463008614 PAS domain; Region: PAS; smart00091 645463008615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463008616 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463008617 Walker A motif; other site 645463008618 ATP binding site [chemical binding]; other site 645463008619 Walker B motif; other site 645463008620 arginine finger; other site 645463008621 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463008622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463008623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463008624 homodimer interface [polypeptide binding]; other site 645463008625 catalytic residue [active] 645463008626 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 645463008627 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 645463008628 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 645463008629 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008630 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008631 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008632 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463008633 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463008634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463008635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463008636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645463008637 dimerization interface [polypeptide binding]; other site 645463008638 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_6; cd07584 645463008639 putative active site [active] 645463008640 catalytic triad [active] 645463008641 putative dimer interface [polypeptide binding]; other site 645463008642 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463008643 Na binding site [ion binding]; other site 645463008644 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 645463008645 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 645463008646 dimer interface [polypeptide binding]; other site 645463008647 anticodon binding site; other site 645463008648 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 645463008649 homodimer interface [polypeptide binding]; other site 645463008650 motif 1; other site 645463008651 active site 645463008652 motif 2; other site 645463008653 GAD domain; Region: GAD; pfam02938 645463008654 motif 3; other site 645463008655 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 645463008656 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 645463008657 dimer interface [polypeptide binding]; other site 645463008658 motif 1; other site 645463008659 active site 645463008660 motif 2; other site 645463008661 motif 3; other site 645463008662 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 645463008663 anticodon binding site; other site 645463008664 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 645463008665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463008666 FeS/SAM binding site; other site 645463008667 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 645463008668 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 645463008669 putative active site [active] 645463008670 dimerization interface [polypeptide binding]; other site 645463008671 putative tRNAtyr binding site [nucleotide binding]; other site 645463008672 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 645463008673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 645463008674 Zn2+ binding site [ion binding]; other site 645463008675 Mg2+ binding site [ion binding]; other site 645463008676 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 645463008677 synthetase active site [active] 645463008678 NTP binding site [chemical binding]; other site 645463008679 metal binding site [ion binding]; metal-binding site 645463008680 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 645463008681 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 645463008682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463008683 active site 645463008684 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 645463008685 DHH family; Region: DHH; pfam01368 645463008686 DHHA1 domain; Region: DHHA1; pfam02272 645463008687 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 645463008688 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 645463008689 active site 645463008690 ATP binding site [chemical binding]; other site 645463008691 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 645463008692 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 645463008693 trimer interface [polypeptide binding]; other site 645463008694 putative metal binding site [ion binding]; other site 645463008695 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 645463008696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 645463008697 FeS/SAM binding site; other site 645463008698 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 645463008699 Staphylococcal AgrD protein; Region: AgrD; cl05477 645463008700 Accessory gene regulator B; Region: AgrB; pfam04647 645463008701 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008702 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008703 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008704 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008705 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008706 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 645463008707 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 645463008708 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 645463008709 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 645463008710 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 645463008711 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 645463008712 dimerization domain swap beta strand [polypeptide binding]; other site 645463008713 regulatory protein interface [polypeptide binding]; other site 645463008714 active site 645463008715 regulatory phosphorylation site [posttranslational modification]; other site 645463008716 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 645463008717 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 645463008718 active site 645463008719 nucleophile elbow; other site 645463008720 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 645463008721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463008722 S-adenosylmethionine binding site [chemical binding]; other site 645463008723 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 645463008724 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 645463008725 Transcriptional regulator; Region: Rrf2; cl17282 645463008726 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 645463008727 nucleotidyl binding site; other site 645463008728 metal binding site [ion binding]; metal-binding site 645463008729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463008730 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463008731 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463008732 active site 645463008733 metal binding site [ion binding]; metal-binding site 645463008734 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 645463008735 active site 645463008736 dimer interface [polypeptide binding]; other site 645463008737 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 645463008738 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 645463008739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463008740 active site 645463008741 motif I; other site 645463008742 motif II; other site 645463008743 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463008744 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645463008745 Transcriptional regulator [Transcription]; Region: LytR; COG1316 645463008746 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 645463008747 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008748 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008749 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463008751 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463008752 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 645463008753 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463008754 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 645463008755 CoA binding domain; Region: CoA_binding; cl17356 645463008756 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 645463008757 NAD(P) binding site [chemical binding]; other site 645463008758 homodimer interface [polypeptide binding]; other site 645463008759 substrate binding site [chemical binding]; other site 645463008760 active site 645463008761 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 645463008762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 645463008763 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 645463008764 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 645463008765 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 645463008766 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 645463008767 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 645463008768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645463008769 active site 645463008770 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463008771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645463008772 active site 645463008773 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463008774 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 645463008775 active site 645463008776 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 645463008777 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 645463008778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463008779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 645463008780 active site 645463008781 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 645463008782 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 645463008783 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 645463008784 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 645463008785 Substrate binding site; other site 645463008786 Cupin domain; Region: Cupin_2; cl17218 645463008787 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 645463008788 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 645463008789 active site 645463008790 substrate binding site [chemical binding]; other site 645463008791 metal binding site [ion binding]; metal-binding site 645463008792 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 645463008793 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 645463008794 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008795 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008796 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008797 Bacterial sugar transferase; Region: Bac_transf; pfam02397 645463008798 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008799 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008800 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008801 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 645463008802 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 645463008803 active site 645463008804 metal binding site [ion binding]; metal-binding site 645463008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 645463008806 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008807 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008808 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008809 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 645463008810 active site 645463008811 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008812 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008813 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008814 GtrA-like protein; Region: GtrA; pfam04138 645463008815 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008816 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008817 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008818 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 645463008819 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008820 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008821 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008822 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 645463008823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463008824 ATP binding site [chemical binding]; other site 645463008825 putative Mg++ binding site [ion binding]; other site 645463008826 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 645463008827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463008828 nucleotide binding region [chemical binding]; other site 645463008829 ATP-binding site [chemical binding]; other site 645463008830 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 645463008831 Low molecular weight S layer protein N terminal; Region: LMWSLP_N; pfam12211 645463008832 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008833 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008834 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008835 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008836 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008837 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 645463008838 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645463008839 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008840 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008841 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008842 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 645463008843 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645463008844 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008845 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008846 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008847 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 645463008848 Interdomain contacts; other site 645463008849 Cytokine receptor motif; other site 645463008850 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 645463008851 Peptidase M60-like family; Region: M60-like; cl19940 645463008852 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 645463008853 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008854 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008855 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008856 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 645463008857 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008858 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008859 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463008860 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 645463008861 Preprotein translocase subunit; Region: YajC; pfam02699 645463008862 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 645463008863 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 645463008864 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 645463008865 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 645463008866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463008867 Walker A motif; other site 645463008868 ATP binding site [chemical binding]; other site 645463008869 Walker B motif; other site 645463008870 arginine finger; other site 645463008871 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 645463008872 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 645463008873 RuvA N terminal domain; Region: RuvA_N; pfam01330 645463008874 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 645463008875 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 645463008876 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 645463008877 active site 645463008878 putative DNA-binding cleft [nucleotide binding]; other site 645463008879 dimer interface [polypeptide binding]; other site 645463008880 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 645463008881 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 645463008882 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 645463008883 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 645463008884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 645463008885 GntP family permease; Region: GntP_permease; pfam02447 645463008886 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 645463008887 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 645463008888 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 645463008889 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 645463008890 Transcriptional regulators [Transcription]; Region: GntR; COG1802 645463008891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463008892 DNA-binding site [nucleotide binding]; DNA binding site 645463008893 FCD domain; Region: FCD; pfam07729 645463008894 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 645463008895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463008896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463008897 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 645463008898 Walker A/P-loop; other site 645463008899 ATP binding site [chemical binding]; other site 645463008900 Q-loop/lid; other site 645463008901 ABC transporter signature motif; other site 645463008902 Walker B; other site 645463008903 D-loop; other site 645463008904 H-loop/switch region; other site 645463008905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 645463008906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 645463008907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463008908 Walker A/P-loop; other site 645463008909 ATP binding site [chemical binding]; other site 645463008910 Q-loop/lid; other site 645463008911 ABC transporter signature motif; other site 645463008912 Walker B; other site 645463008913 D-loop; other site 645463008914 H-loop/switch region; other site 645463008915 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 645463008916 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 645463008917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463008918 catalytic residue [active] 645463008919 HTH-like domain; Region: HTH_21; pfam13276 645463008920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 645463008921 Integrase core domain; Region: rve; pfam00665 645463008922 Integrase core domain; Region: rve_2; pfam13333 645463008923 hypothetical protein; Provisional; Region: PRK10519 645463008924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 645463008925 Nucleoside recognition; Region: Gate; pfam07670 645463008926 glutamate carboxypeptidase; Reviewed; Region: PRK06133 645463008927 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 645463008928 metal binding site [ion binding]; metal-binding site 645463008929 dimer interface [polypeptide binding]; other site 645463008930 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 645463008931 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463008932 DNA binding residues [nucleotide binding] 645463008933 dimer interface [polypeptide binding]; other site 645463008934 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 645463008935 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 645463008936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463008937 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463008938 Probable transposase; Region: OrfB_IS605; pfam01385 645463008939 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463008940 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645463008941 phosphate binding site [ion binding]; other site 645463008942 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463008943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463008944 aspartate aminotransferase; Provisional; Region: PRK06836 645463008945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463008946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463008947 homodimer interface [polypeptide binding]; other site 645463008948 catalytic residue [active] 645463008949 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 645463008950 EamA-like transporter family; Region: EamA; pfam00892 645463008951 EamA-like transporter family; Region: EamA; pfam00892 645463008952 Anthrax toxin lethal factor, N- and C-terminal domain; Region: ATLF; pfam07737 645463008953 PPP4R2; Region: PPP4R2; pfam09184 645463008954 Collagen binding domain; Region: Collagen_bind; pfam05737 645463008955 Collagen binding domain; Region: Collagen_bind; pfam05737 645463008956 Cna protein B-type domain; Region: Cna_B; pfam05738 645463008957 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645463008958 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 645463008959 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 645463008960 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 645463008961 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 645463008962 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 645463008963 Soluble P-type ATPase [General function prediction only]; Region: COG4087 645463008964 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 645463008965 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 645463008966 dimer interface [polypeptide binding]; other site 645463008967 active site 645463008968 glycine-pyridoxal phosphate binding site [chemical binding]; other site 645463008969 folate binding site [chemical binding]; other site 645463008970 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 645463008971 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463008972 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463008973 metal binding site [ion binding]; metal-binding site 645463008974 dimer interface [polypeptide binding]; other site 645463008975 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463008976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645463008977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463008978 active site 645463008979 phosphorylation site [posttranslational modification] 645463008980 intermolecular recognition site; other site 645463008981 dimerization interface [polypeptide binding]; other site 645463008982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463008983 Cupin domain; Region: Cupin_2; pfam07883 645463008984 Histidine kinase; Region: His_kinase; pfam06580 645463008985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463008986 ATP binding site [chemical binding]; other site 645463008987 Mg2+ binding site [ion binding]; other site 645463008988 G-X-G motif; other site 645463008989 seryl-tRNA synthetase; Provisional; Region: PRK05431 645463008990 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 645463008991 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 645463008992 dimer interface [polypeptide binding]; other site 645463008993 active site 645463008994 motif 1; other site 645463008995 motif 2; other site 645463008996 motif 3; other site 645463008997 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 645463008998 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 645463008999 active site 645463009000 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 645463009001 putative active site [active] 645463009002 catalytic triad [active] 645463009003 putative dimer interface [polypeptide binding]; other site 645463009004 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 645463009005 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 645463009006 NADP binding site [chemical binding]; other site 645463009007 dimer interface [polypeptide binding]; other site 645463009008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463009009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463009010 dimerization interface [polypeptide binding]; other site 645463009011 putative DNA binding site [nucleotide binding]; other site 645463009012 putative Zn2+ binding site [ion binding]; other site 645463009013 Rubrerythrin [Energy production and conversion]; Region: COG1592 645463009014 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 645463009015 binuclear metal center [ion binding]; other site 645463009016 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 645463009017 iron binding site [ion binding]; other site 645463009018 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 645463009019 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 645463009020 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 645463009021 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 645463009022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463009023 motif II; other site 645463009024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 645463009025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463009026 catalytic residue [active] 645463009027 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 645463009028 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 645463009029 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 645463009030 Phosphopantetheine attachment site; Region: PP-binding; cl09936 645463009031 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 645463009032 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 645463009033 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 645463009034 acyl-activating enzyme (AAE) consensus motif; other site 645463009035 AMP binding site [chemical binding]; other site 645463009036 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 645463009037 DltD central region; Region: DltD_M; pfam04918 645463009038 DltD C-terminal region; Region: DltD_C; pfam04914 645463009039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645463009040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645463009041 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 645463009042 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463009043 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 645463009044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463009045 motif II; other site 645463009046 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 645463009047 Domain of unknown function DUF21; Region: DUF21; pfam01595 645463009048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 645463009049 Transporter associated domain; Region: CorC_HlyC; smart01091 645463009050 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 645463009051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463009052 active site 645463009053 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463009054 active site 645463009055 PAS domain; Region: PAS; smart00091 645463009056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463009057 Walker A motif; other site 645463009058 ATP binding site [chemical binding]; other site 645463009059 Walker B motif; other site 645463009060 arginine finger; other site 645463009061 Putative lysophospholipase; Region: Hydrolase_4; cl19140 645463009062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463009063 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 645463009064 Ferritin-like domain; Region: Ferritin; pfam00210 645463009065 dinuclear metal binding motif [ion binding]; other site 645463009066 FtsX-like permease family; Region: FtsX; pfam02687 645463009067 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463009068 FtsX-like permease family; Region: FtsX; pfam02687 645463009069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463009070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463009071 Walker A/P-loop; other site 645463009072 ATP binding site [chemical binding]; other site 645463009073 Q-loop/lid; other site 645463009074 ABC transporter signature motif; other site 645463009075 Walker B; other site 645463009076 D-loop; other site 645463009077 H-loop/switch region; other site 645463009078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463009079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463009080 ATP binding site [chemical binding]; other site 645463009081 Mg2+ binding site [ion binding]; other site 645463009082 G-X-G motif; other site 645463009083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463009084 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 645463009085 active site 645463009086 phosphorylation site [posttranslational modification] 645463009087 intermolecular recognition site; other site 645463009088 dimerization interface [polypeptide binding]; other site 645463009089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463009090 DNA binding site [nucleotide binding] 645463009091 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 645463009092 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 645463009093 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 645463009094 FAD dependent oxidoreductase; Region: DAO; pfam01266 645463009095 Propionate catabolism activator; Region: PrpR_N; pfam06506 645463009096 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 645463009097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 645463009098 putative active site [active] 645463009099 heme pocket [chemical binding]; other site 645463009100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463009101 Walker A motif; other site 645463009102 ATP binding site [chemical binding]; other site 645463009103 Walker B motif; other site 645463009104 arginine finger; other site 645463009105 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 645463009106 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 645463009107 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 645463009108 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 645463009109 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 645463009110 nucleotidyl binding site; other site 645463009111 metal binding site [ion binding]; metal-binding site 645463009112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463009113 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463009114 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463009115 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645463009116 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645463009117 Walker A/P-loop; other site 645463009118 ATP binding site [chemical binding]; other site 645463009119 Q-loop/lid; other site 645463009120 ABC transporter signature motif; other site 645463009121 Walker B; other site 645463009122 D-loop; other site 645463009123 H-loop/switch region; other site 645463009124 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 645463009125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645463009126 ABC-ATPase subunit interface; other site 645463009127 dimer interface [polypeptide binding]; other site 645463009128 putative PBP binding regions; other site 645463009129 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 645463009130 ABC-ATPase subunit interface; other site 645463009131 dimer interface [polypeptide binding]; other site 645463009132 putative PBP binding regions; other site 645463009133 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645463009134 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645463009135 intersubunit interface [polypeptide binding]; other site 645463009136 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 645463009137 methionine cluster; other site 645463009138 active site 645463009139 phosphorylation site [posttranslational modification] 645463009140 metal binding site [ion binding]; metal-binding site 645463009141 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 645463009142 putative active site [active] 645463009143 YdjC motif; other site 645463009144 Mg binding site [ion binding]; other site 645463009145 putative homodimer interface [polypeptide binding]; other site 645463009146 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645463009147 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 645463009148 NAD binding site [chemical binding]; other site 645463009149 sugar binding site [chemical binding]; other site 645463009150 divalent metal binding site [ion binding]; other site 645463009151 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463009152 dimer interface [polypeptide binding]; other site 645463009153 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463009154 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463009155 active site 645463009156 P-loop; other site 645463009157 phosphorylation site [posttranslational modification] 645463009158 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463009159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463009160 DNA-binding site [nucleotide binding]; DNA binding site 645463009161 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 645463009162 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463009163 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 645463009164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463009165 metal binding site [ion binding]; metal-binding site 645463009166 active site 645463009167 I-site; other site 645463009168 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 645463009169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463009170 dimer interface [polypeptide binding]; other site 645463009171 conserved gate region; other site 645463009172 putative PBP binding loops; other site 645463009173 ABC-ATPase subunit interface; other site 645463009174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463009175 dimer interface [polypeptide binding]; other site 645463009176 conserved gate region; other site 645463009177 putative PBP binding loops; other site 645463009178 ABC-ATPase subunit interface; other site 645463009179 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 645463009180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463009181 Walker A/P-loop; other site 645463009182 ATP binding site [chemical binding]; other site 645463009183 Q-loop/lid; other site 645463009184 ABC transporter signature motif; other site 645463009185 Walker B; other site 645463009186 D-loop; other site 645463009187 H-loop/switch region; other site 645463009188 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463009189 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 645463009190 V-type ATP synthase subunit B; Provisional; Region: PRK04196 645463009191 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645463009192 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 645463009193 Walker A motif homologous position; other site 645463009194 Walker B motif; other site 645463009195 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645463009196 V-type ATP synthase subunit A; Provisional; Region: PRK04192 645463009197 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645463009198 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 645463009199 Walker A motif/ATP binding site; other site 645463009200 Walker B motif; other site 645463009201 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645463009202 V-type ATP synthase subunit F; Provisional; Region: PRK01395 645463009203 V-type ATP synthase subunit C; Provisional; Region: PRK01198 645463009204 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 645463009205 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 645463009206 V-type ATP synthase subunit K; Validated; Region: PRK06558 645463009207 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 645463009208 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 645463009209 V-type ATP synthase subunit I; Validated; Region: PRK05771 645463009210 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 645463009211 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645463009212 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 645463009213 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645463009214 B3/4 domain; Region: B3_4; cl19243 645463009215 Cache domain; Region: Cache_1; pfam02743 645463009216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463009217 metal binding site [ion binding]; metal-binding site 645463009218 active site 645463009219 I-site; other site 645463009220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463009221 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 645463009222 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 645463009223 putative catalytic cysteine [active] 645463009224 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 645463009225 putative active site [active] 645463009226 metal binding site [ion binding]; metal-binding site 645463009227 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 645463009228 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 645463009229 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 645463009230 NAD(P) binding pocket [chemical binding]; other site 645463009231 acyl-CoA synthetase; Validated; Region: PRK07638 645463009232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 645463009233 AMP binding site [chemical binding]; other site 645463009234 active site 645463009235 acyl-activating enzyme (AAE) consensus motif; other site 645463009236 CoA binding site [chemical binding]; other site 645463009237 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 645463009238 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 645463009239 dimer interface [polypeptide binding]; other site 645463009240 active site 645463009241 BioY family; Region: BioY; pfam02632 645463009242 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463009243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463009244 Coenzyme A binding pocket [chemical binding]; other site 645463009245 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 645463009246 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 645463009247 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 645463009248 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 645463009249 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 645463009250 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 645463009251 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cd09658 645463009252 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 645463009253 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl18979 645463009254 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 645463009255 WYL domain; Region: WYL; pfam13280 645463009256 FtsX-like permease family; Region: FtsX; pfam02687 645463009257 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463009258 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463009259 Walker A/P-loop; other site 645463009260 ATP binding site [chemical binding]; other site 645463009261 Q-loop/lid; other site 645463009262 ABC transporter signature motif; other site 645463009263 Walker B; other site 645463009264 D-loop; other site 645463009265 H-loop/switch region; other site 645463009266 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 645463009267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463009268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463009269 dimer interface [polypeptide binding]; other site 645463009270 phosphorylation site [posttranslational modification] 645463009271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463009272 ATP binding site [chemical binding]; other site 645463009273 Mg2+ binding site [ion binding]; other site 645463009274 G-X-G motif; other site 645463009275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463009276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463009277 active site 645463009278 phosphorylation site [posttranslational modification] 645463009279 intermolecular recognition site; other site 645463009280 dimerization interface [polypeptide binding]; other site 645463009281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463009282 DNA binding site [nucleotide binding] 645463009283 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 645463009284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 645463009285 substrate binding pocket [chemical binding]; other site 645463009286 membrane-bound complex binding site; other site 645463009287 hinge residues; other site 645463009288 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 645463009289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463009290 Walker A/P-loop; other site 645463009291 ATP binding site [chemical binding]; other site 645463009292 Q-loop/lid; other site 645463009293 ABC transporter signature motif; other site 645463009294 Walker B; other site 645463009295 D-loop; other site 645463009296 H-loop/switch region; other site 645463009297 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 645463009298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463009299 dimer interface [polypeptide binding]; other site 645463009300 conserved gate region; other site 645463009301 putative PBP binding loops; other site 645463009302 ABC-ATPase subunit interface; other site 645463009303 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463009304 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 645463009305 dimer interface [polypeptide binding]; other site 645463009306 putative radical transfer pathway; other site 645463009307 diiron center [ion binding]; other site 645463009308 tyrosyl radical; other site 645463009309 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 645463009310 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 645463009311 Class I ribonucleotide reductase; Region: RNR_I; cd01679 645463009312 active site 645463009313 dimer interface [polypeptide binding]; other site 645463009314 catalytic residues [active] 645463009315 effector binding site; other site 645463009316 R2 peptide binding site; other site 645463009317 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645463009318 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 645463009319 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645463009320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645463009321 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 645463009322 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 645463009323 Walker A/P-loop; other site 645463009324 ATP binding site [chemical binding]; other site 645463009325 Q-loop/lid; other site 645463009326 ABC transporter signature motif; other site 645463009327 Walker B; other site 645463009328 D-loop; other site 645463009329 H-loop/switch region; other site 645463009330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463009331 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463009332 Probable transposase; Region: OrfB_IS605; pfam01385 645463009333 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 645463009334 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 645463009335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 645463009336 intersubunit interface [polypeptide binding]; other site 645463009337 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 645463009338 inhibitor site; inhibition site 645463009339 active site 645463009340 dimer interface [polypeptide binding]; other site 645463009341 catalytic residue [active] 645463009342 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 645463009343 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 645463009344 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 645463009345 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 645463009346 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 645463009347 Transcriptional regulator [Transcription]; Region: IclR; COG1414 645463009348 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 645463009349 Bacterial transcriptional regulator; Region: IclR; pfam01614 645463009350 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 645463009351 dimer interface [polypeptide binding]; other site 645463009352 active site 645463009353 metal binding site [ion binding]; metal-binding site 645463009354 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463009355 Bacterial SH3 domain; Region: SH3_3; pfam08239 645463009356 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 645463009357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 645463009358 uncharacterized conserved protein fragment 645463009359 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 645463009360 Squalene epoxidase; Region: SE; cl17314 645463009361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463009362 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 645463009363 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 645463009364 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 645463009365 catalytic residues [active] 645463009366 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463009367 alpha-mannosidase; Provisional; Region: PRK09819 645463009368 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 645463009369 active site 645463009370 metal binding site [ion binding]; metal-binding site 645463009371 catalytic site [active] 645463009372 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 645463009373 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 645463009374 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463009375 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463009376 active site 645463009377 P-loop; other site 645463009378 phosphorylation site [posttranslational modification] 645463009379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009380 active site 645463009381 phosphorylation site [posttranslational modification] 645463009382 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463009383 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463009384 HTH domain; Region: HTH_11; pfam08279 645463009385 PRD domain; Region: PRD; pfam00874 645463009386 PRD domain; Region: PRD; pfam00874 645463009387 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463009388 active site 645463009389 P-loop; other site 645463009390 phosphorylation site [posttranslational modification] 645463009391 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009392 active site 645463009393 phosphorylation site [posttranslational modification] 645463009394 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 645463009395 Sugar transport protein; Region: Sugar_transport; cl19288 645463009396 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 645463009397 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 645463009398 gating phenylalanine in ion channel; other site 645463009399 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 645463009400 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 645463009401 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 645463009402 Right handed beta helix region; Region: Beta_helix; pfam13229 645463009403 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 645463009404 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 645463009405 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463009406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645463009407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 645463009408 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 645463009409 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463009410 HPr interaction site; other site 645463009411 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009412 active site 645463009413 phosphorylation site [posttranslational modification] 645463009414 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 645463009415 putative active site [active] 645463009416 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463009417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463009418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463009419 homodimer interface [polypeptide binding]; other site 645463009420 catalytic residue [active] 645463009421 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 645463009422 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009424 active site turn [active] 645463009425 phosphorylation site [posttranslational modification] 645463009426 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463009427 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463009428 PRD domain; Region: PRD; pfam00874 645463009429 PRD domain; Region: PRD; pfam00874 645463009430 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 645463009431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463009432 catalytic residue [active] 645463009433 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 645463009434 catalytic residues [active] 645463009435 Predicted transcriptional regulators [Transcription]; Region: COG1378 645463009436 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 645463009437 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 645463009438 C-terminal domain interface [polypeptide binding]; other site 645463009439 sugar binding site [chemical binding]; other site 645463009440 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 645463009441 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 645463009442 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 645463009443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463009444 putative substrate translocation pore; other site 645463009445 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 645463009446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 645463009447 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 645463009448 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 645463009449 metal ion-dependent adhesion site (MIDAS); other site 645463009450 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463009451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463009452 Walker A motif; other site 645463009453 ATP binding site [chemical binding]; other site 645463009454 Walker B motif; other site 645463009455 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 645463009456 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 645463009457 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 645463009458 Predicted membrane protein [Function unknown]; Region: COG4129 645463009459 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 645463009460 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 645463009461 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 645463009462 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463009463 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463009464 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463009465 putative active site [active] 645463009466 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463009467 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 645463009468 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 645463009469 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 645463009470 putative active site [active] 645463009471 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 645463009472 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463009473 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463009474 active site 645463009475 P-loop; other site 645463009476 phosphorylation site [posttranslational modification] 645463009477 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 645463009478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463009479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463009480 ATP binding site [chemical binding]; other site 645463009481 Mg2+ binding site [ion binding]; other site 645463009482 G-X-G motif; other site 645463009483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463009484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463009485 active site 645463009486 phosphorylation site [posttranslational modification] 645463009487 intermolecular recognition site; other site 645463009488 dimerization interface [polypeptide binding]; other site 645463009489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463009490 DNA binding site [nucleotide binding] 645463009491 FtsX-like permease family; Region: FtsX; pfam02687 645463009492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463009493 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463009494 Walker A/P-loop; other site 645463009495 ATP binding site [chemical binding]; other site 645463009496 Q-loop/lid; other site 645463009497 ABC transporter signature motif; other site 645463009498 Walker B; other site 645463009499 D-loop; other site 645463009500 H-loop/switch region; other site 645463009501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463009502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 645463009503 putative substrate translocation pore; other site 645463009504 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 645463009505 HPr interaction site; other site 645463009506 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009507 active site 645463009508 phosphorylation site [posttranslational modification] 645463009509 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 645463009510 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 645463009511 NAD binding site [chemical binding]; other site 645463009512 sugar binding site [chemical binding]; other site 645463009513 divalent metal binding site [ion binding]; other site 645463009514 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463009515 dimer interface [polypeptide binding]; other site 645463009516 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 645463009517 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009518 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009519 active site turn [active] 645463009520 phosphorylation site [posttranslational modification] 645463009521 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463009522 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463009523 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463009524 putative active site [active] 645463009525 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 645463009526 Active site serine [active] 645463009527 xylose isomerase; Provisional; Region: PRK05474 645463009528 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 645463009529 N- and C-terminal domain interface [polypeptide binding]; other site 645463009530 D-xylulose kinase; Region: XylB; TIGR01312 645463009531 active site 645463009532 MgATP binding site [chemical binding]; other site 645463009533 catalytic site [active] 645463009534 metal binding site [ion binding]; metal-binding site 645463009535 xylulose binding site [chemical binding]; other site 645463009536 homodimer interface [polypeptide binding]; other site 645463009537 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463009538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 645463009539 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 645463009540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 645463009541 nucleotide binding site [chemical binding]; other site 645463009542 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 645463009543 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 645463009544 active pocket/dimerization site; other site 645463009545 active site 645463009546 phosphorylation site [posttranslational modification] 645463009547 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 645463009548 active site 645463009549 phosphorylation site [posttranslational modification] 645463009550 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 645463009551 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 645463009552 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 645463009553 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 645463009554 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 645463009555 putative active site [active] 645463009556 putative catalytic site [active] 645463009557 Protein of unknown function (DUF523); Region: DUF523; cl00733 645463009558 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 645463009559 Protein of unknown function DUF262; Region: DUF262; pfam03235 645463009560 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 645463009561 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 645463009562 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 645463009563 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 645463009564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463009565 ATP binding site [chemical binding]; other site 645463009566 putative Mg++ binding site [ion binding]; other site 645463009567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463009568 nucleotide binding region [chemical binding]; other site 645463009569 ATP-binding site [chemical binding]; other site 645463009570 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 645463009571 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 645463009572 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 645463009573 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 645463009574 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 645463009575 HsdM N-terminal domain; Region: HsdM_N; pfam12161 645463009576 Methyltransferase domain; Region: Methyltransf_26; pfam13659 645463009577 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645463009578 intersubunit interface [polypeptide binding]; other site 645463009579 active site 645463009580 zinc binding site [ion binding]; other site 645463009581 Na+ binding site [ion binding]; other site 645463009582 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 645463009583 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463009584 active site 645463009585 P-loop; other site 645463009586 phosphorylation site [posttranslational modification] 645463009587 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463009588 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009589 active site 645463009590 phosphorylation site [posttranslational modification] 645463009591 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 645463009592 putative substrate binding site [chemical binding]; other site 645463009593 putative ATP binding site [chemical binding]; other site 645463009594 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463009595 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463009596 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463009597 putative active site [active] 645463009598 Predicted membrane protein [Function unknown]; Region: COG2364 645463009599 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645463009600 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463009601 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 645463009602 active site 645463009603 methionine cluster; other site 645463009604 phosphorylation site [posttranslational modification] 645463009605 metal binding site [ion binding]; metal-binding site 645463009606 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463009607 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463009608 active site 645463009609 P-loop; other site 645463009610 phosphorylation site [posttranslational modification] 645463009611 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463009612 HTH domain; Region: HTH_11; pfam08279 645463009613 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463009614 PRD domain; Region: PRD; pfam00874 645463009615 PRD domain; Region: PRD; pfam00874 645463009616 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 645463009617 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463009618 active site 645463009619 phosphorylation site [posttranslational modification] 645463009620 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 645463009621 alpha-mannosidase; Provisional; Region: PRK09819 645463009622 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 645463009623 active site 645463009624 metal binding site [ion binding]; metal-binding site 645463009625 catalytic site [active] 645463009626 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 645463009627 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 645463009628 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 645463009629 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009630 active site 645463009631 phosphorylation site [posttranslational modification] 645463009632 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463009633 active site 645463009634 P-loop; other site 645463009635 phosphorylation site [posttranslational modification] 645463009636 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463009637 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 645463009638 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 645463009639 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 645463009640 putative active site [active] 645463009641 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 645463009642 putative active site [active] 645463009643 YdjC motif; other site 645463009644 Mg binding site [ion binding]; other site 645463009645 putative homodimer interface [polypeptide binding]; other site 645463009646 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009647 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 645463009648 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009649 active site turn [active] 645463009650 phosphorylation site [posttranslational modification] 645463009651 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463009652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463009653 DNA-binding site [nucleotide binding]; DNA binding site 645463009654 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 645463009655 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 645463009656 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 645463009657 Ca binding site [ion binding]; other site 645463009658 active site 645463009659 catalytic site [active] 645463009660 amino acid transporter; Region: 2A0306; TIGR00909 645463009661 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 645463009662 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 645463009663 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 645463009664 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 645463009665 catalytic triad [active] 645463009666 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463009667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463009668 Walker A motif; other site 645463009669 ATP binding site [chemical binding]; other site 645463009670 Walker B motif; other site 645463009671 arginine finger; other site 645463009672 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463009673 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 645463009674 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645463009675 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009676 active site turn [active] 645463009677 phosphorylation site [posttranslational modification] 645463009678 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009679 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463009680 HPr interaction site; other site 645463009681 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009682 active site 645463009683 phosphorylation site [posttranslational modification] 645463009684 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463009685 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463009686 PRD domain; Region: PRD; pfam00874 645463009687 PRD domain; Region: PRD; pfam00874 645463009688 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 645463009689 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 645463009690 metal binding site [ion binding]; metal-binding site 645463009691 Predicted membrane protein [Function unknown]; Region: COG1288 645463009692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009693 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 645463009694 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009695 active site turn [active] 645463009696 phosphorylation site [posttranslational modification] 645463009697 dipeptidase PepV; Reviewed; Region: PRK07318 645463009698 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 645463009699 active site 645463009700 metal binding site [ion binding]; metal-binding site 645463009701 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463009702 HPr interaction site; other site 645463009703 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009704 active site 645463009705 phosphorylation site [posttranslational modification] 645463009706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463009707 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 645463009708 active site 645463009709 motif I; other site 645463009710 motif II; other site 645463009711 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 645463009712 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 645463009713 putative active site [active] 645463009714 metal binding site [ion binding]; metal-binding site 645463009715 Class I aldolases; Region: Aldolase_Class_I; cl17187 645463009716 catalytic residue [active] 645463009717 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463009718 HTH domain; Region: HTH_11; pfam08279 645463009719 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463009720 PRD domain; Region: PRD; pfam00874 645463009721 PRD domain; Region: PRD; pfam00874 645463009722 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463009723 active site 645463009724 P-loop; other site 645463009725 phosphorylation site [posttranslational modification] 645463009726 Uncharacterized conserved protein [Function unknown]; Region: COG1284 645463009727 Domain of unknown function (DUF373); Region: DUF373; cl12079 645463009728 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 645463009729 phosphate binding site [ion binding]; other site 645463009730 6-phosphofructokinase; Provisional; Region: PRK14072 645463009731 active site 645463009732 ADP/pyrophosphate binding site [chemical binding]; other site 645463009733 dimerization interface [polypeptide binding]; other site 645463009734 allosteric effector site; other site 645463009735 fructose-1,6-bisphosphate binding site; other site 645463009736 conserved hypothetical protein pseudogene 645463009737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463009738 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463009739 Probable transposase; Region: OrfB_IS605; pfam01385 645463009740 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463009741 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463009742 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463009743 metal binding site [ion binding]; metal-binding site 645463009744 dimer interface [polypeptide binding]; other site 645463009745 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 645463009746 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463009747 putative metal binding site [ion binding]; other site 645463009748 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 645463009749 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463009750 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645463009751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009752 active site turn [active] 645463009753 phosphorylation site [posttranslational modification] 645463009754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009755 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463009756 HPr interaction site; other site 645463009757 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009758 active site 645463009759 phosphorylation site [posttranslational modification] 645463009760 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463009761 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463009762 PRD domain; Region: PRD; pfam00874 645463009763 PRD domain; Region: PRD; pfam00874 645463009764 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 645463009765 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 645463009766 glycosyltransferase, MGT family; Region: MGT; TIGR01426 645463009767 active site 645463009768 TDP-binding site; other site 645463009769 acceptor substrate-binding pocket; other site 645463009770 homodimer interface [polypeptide binding]; other site 645463009771 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463009772 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 645463009773 putative catalytic residues [active] 645463009774 catalytic nucleophile [active] 645463009775 Recombinase; Region: Recombinase; pfam07508 645463009776 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 645463009777 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 645463009778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463009779 non-specific DNA binding site [nucleotide binding]; other site 645463009780 salt bridge; other site 645463009781 sequence-specific DNA binding site [nucleotide binding]; other site 645463009782 Replication initiation factor; Region: Rep_trans; pfam02486 645463009783 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 645463009784 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 645463009785 active site 645463009786 FMN binding site [chemical binding]; other site 645463009787 substrate binding site [chemical binding]; other site 645463009788 putative catalytic residue [active] 645463009789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463009790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 645463009791 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 645463009792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463009793 putative substrate translocation pore; other site 645463009794 Predicted transcriptional regulators [Transcription]; Region: COG1695 645463009795 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 645463009796 Flavodoxin domain; Region: Flavodoxin_5; cl17428 645463009797 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463009798 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463009799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463009800 dimerization interface [polypeptide binding]; other site 645463009801 putative DNA binding site [nucleotide binding]; other site 645463009802 putative Zn2+ binding site [ion binding]; other site 645463009803 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463009804 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 645463009805 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463009806 FMN binding site [chemical binding]; other site 645463009807 dimer interface [polypeptide binding]; other site 645463009808 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 645463009809 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463009810 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 645463009811 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009812 active site turn [active] 645463009813 phosphorylation site [posttranslational modification] 645463009814 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009815 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 645463009816 HPr interaction site; other site 645463009817 glycerol kinase (GK) interaction site [polypeptide binding]; other site 645463009818 active site 645463009819 phosphorylation site [posttranslational modification] 645463009820 CAT RNA binding domain; Region: CAT_RBD; smart01061 645463009821 transcriptional antiterminator BglG; Provisional; Region: PRK09772 645463009822 PRD domain; Region: PRD; pfam00874 645463009823 PRD domain; Region: PRD; pfam00874 645463009824 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 645463009825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 645463009826 active site turn [active] 645463009827 phosphorylation site [posttranslational modification] 645463009828 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 645463009829 beta-phosphoglucomutase; Region: bPGM; TIGR01990 645463009830 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 645463009831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463009832 motif II; other site 645463009833 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 645463009834 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 645463009835 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 645463009836 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 645463009837 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 645463009838 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 645463009839 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 645463009840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463009841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463009842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463009843 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009844 active site 645463009845 phosphorylation site [posttranslational modification] 645463009846 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463009847 HTH domain; Region: HTH_11; pfam08279 645463009848 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463009849 PRD domain; Region: PRD; pfam00874 645463009850 PRD domain; Region: PRD; pfam00874 645463009851 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463009852 active site 645463009853 P-loop; other site 645463009854 phosphorylation site [posttranslational modification] 645463009855 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 645463009856 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463009857 active site 645463009858 phosphorylation site [posttranslational modification] 645463009859 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 645463009860 active site 645463009861 P-loop; other site 645463009862 phosphorylation site [posttranslational modification] 645463009863 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 645463009864 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645463009865 intersubunit interface [polypeptide binding]; other site 645463009866 active site 645463009867 zinc binding site [ion binding]; other site 645463009868 Na+ binding site [ion binding]; other site 645463009869 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 645463009870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463009871 dimer interface [polypeptide binding]; other site 645463009872 conserved gate region; other site 645463009873 putative PBP binding loops; other site 645463009874 ABC-ATPase subunit interface; other site 645463009875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463009876 dimer interface [polypeptide binding]; other site 645463009877 conserved gate region; other site 645463009878 putative PBP binding loops; other site 645463009879 ABC-ATPase subunit interface; other site 645463009880 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 645463009881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463009882 Walker A/P-loop; other site 645463009883 ATP binding site [chemical binding]; other site 645463009884 Q-loop/lid; other site 645463009885 ABC transporter signature motif; other site 645463009886 Walker B; other site 645463009887 D-loop; other site 645463009888 H-loop/switch region; other site 645463009889 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 645463009890 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 645463009891 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 645463009892 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 645463009893 conserved cys residue [active] 645463009894 Predicted transcriptional regulator [Transcription]; Region: COG2378 645463009895 HTH domain; Region: HTH_11; pfam08279 645463009896 WYL domain; Region: WYL; pfam13280 645463009897 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 645463009898 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 645463009899 Protein of unknown function DUF262; Region: DUF262; pfam03235 645463009900 FRG domain; Region: FRG; pfam08867 645463009901 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 645463009902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 645463009903 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 645463009904 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 645463009905 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 645463009906 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 645463009907 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 645463009908 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 645463009909 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 645463009910 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 645463009911 active site 645463009912 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 645463009913 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 645463009914 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 645463009915 Walker A motif; other site 645463009916 ATP binding site [chemical binding]; other site 645463009917 Walker B motif; other site 645463009918 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 645463009919 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 645463009920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463009921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463009922 non-specific DNA binding site [nucleotide binding]; other site 645463009923 salt bridge; other site 645463009924 sequence-specific DNA binding site [nucleotide binding]; other site 645463009925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463009926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463009927 non-specific DNA binding site [nucleotide binding]; other site 645463009928 salt bridge; other site 645463009929 sequence-specific DNA binding site [nucleotide binding]; other site 645463009930 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463009931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463009932 non-specific DNA binding site [nucleotide binding]; other site 645463009933 salt bridge; other site 645463009934 sequence-specific DNA binding site [nucleotide binding]; other site 645463009935 Fic family protein [Function unknown]; Region: COG3177 645463009936 Fic/DOC family; Region: Fic; pfam02661 645463009937 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 645463009938 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 645463009939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463009940 DNA binding site [nucleotide binding] 645463009941 Int/Topo IB signature motif; other site 645463009942 active site 645463009943 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 645463009944 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 645463009945 P63C domain; Region: P63C; pfam10546 645463009946 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 645463009947 SmpB-tmRNA interface; other site 645463009948 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 645463009949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 645463009950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463009951 Coenzyme A binding pocket [chemical binding]; other site 645463009952 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 645463009953 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463009954 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 645463009955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463009956 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 645463009957 Walker A/P-loop; other site 645463009958 ATP binding site [chemical binding]; other site 645463009959 Q-loop/lid; other site 645463009960 ABC transporter signature motif; other site 645463009961 Walker B; other site 645463009962 D-loop; other site 645463009963 H-loop/switch region; other site 645463009964 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 645463009965 ribonuclease R; Region: RNase_R; TIGR02063 645463009966 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 645463009967 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 645463009968 RNB domain; Region: RNB; pfam00773 645463009969 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 645463009970 RNA binding site [nucleotide binding]; other site 645463009971 A new structural DNA glycosylase; Region: AlkD_like; cl11434 645463009972 HEAT repeats; Region: HEAT_2; pfam13646 645463009973 active site 645463009974 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463009975 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 645463009976 substrate binding site [chemical binding]; other site 645463009977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 645463009978 dimer interface [polypeptide binding]; other site 645463009979 metal binding site [ion binding]; metal-binding site 645463009980 Predicted permeases [General function prediction only]; Region: COG0679 645463009981 protein translocase, SecG subunit; Region: secG; TIGR00810 645463009982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 645463009983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463009984 Coenzyme A binding pocket [chemical binding]; other site 645463009985 enolase; Provisional; Region: eno; PRK00077 645463009986 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 645463009987 dimer interface [polypeptide binding]; other site 645463009988 metal binding site [ion binding]; metal-binding site 645463009989 substrate binding pocket [chemical binding]; other site 645463009990 phosphoglyceromutase; Provisional; Region: PRK05434 645463009991 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 645463009992 substrate binding site [chemical binding]; other site 645463009993 dimer interface [polypeptide binding]; other site 645463009994 catalytic triad [active] 645463009995 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 645463009996 substrate binding site [chemical binding]; other site 645463009997 hinge regions; other site 645463009998 ADP binding site [chemical binding]; other site 645463009999 catalytic site [active] 645463010000 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 645463010001 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 645463010002 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 645463010003 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 645463010004 Predicted transcriptional regulator [Transcription]; Region: COG3388 645463010005 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 645463010006 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 645463010007 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 645463010008 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 645463010009 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 645463010010 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 645463010011 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463010012 catalytic loop [active] 645463010013 iron binding site [ion binding]; other site 645463010014 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 645463010015 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 645463010016 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 645463010017 phenylhydantoinase; Validated; Region: PRK08323 645463010018 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 645463010019 tetramer interface [polypeptide binding]; other site 645463010020 active site 645463010021 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 645463010022 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 645463010023 active site 645463010024 FMN binding site [chemical binding]; other site 645463010025 substrate binding site [chemical binding]; other site 645463010026 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 645463010027 Sulfate transporter family; Region: Sulfate_transp; cl19250 645463010028 xanthine permease; Region: pbuX; TIGR03173 645463010029 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 645463010030 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 645463010031 active site 645463010032 putative substrate binding pocket [chemical binding]; other site 645463010033 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 645463010034 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 645463010035 active site 645463010036 putative substrate binding pocket [chemical binding]; other site 645463010037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463010038 peptidase; Reviewed; Region: PRK13004 645463010039 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 645463010040 putative metal binding site [ion binding]; other site 645463010041 putative dimer interface [polypeptide binding]; other site 645463010042 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 645463010043 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 645463010044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463010045 catalytic residue [active] 645463010046 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 645463010047 GAF domain; Region: GAF; cl17456 645463010048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463010050 Walker A motif; other site 645463010051 ATP binding site [chemical binding]; other site 645463010052 Walker B motif; other site 645463010053 arginine finger; other site 645463010054 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 645463010055 homotrimer interaction site [polypeptide binding]; other site 645463010056 putative active site [active] 645463010057 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463010058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463010059 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 645463010060 DNA binding residues [nucleotide binding] 645463010061 putative dimer interface [polypeptide binding]; other site 645463010062 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 645463010063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 645463010064 active site 645463010065 catalytic tetrad [active] 645463010066 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 645463010067 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463010068 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463010069 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 645463010070 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645463010071 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 645463010072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463010073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463010074 Walker A/P-loop; other site 645463010075 ATP binding site [chemical binding]; other site 645463010076 Q-loop/lid; other site 645463010077 ABC transporter signature motif; other site 645463010078 Walker B; other site 645463010079 D-loop; other site 645463010080 H-loop/switch region; other site 645463010081 FtsX-like permease family; Region: FtsX; pfam02687 645463010082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 645463010083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463010084 ATP binding site [chemical binding]; other site 645463010085 Mg2+ binding site [ion binding]; other site 645463010086 G-X-G motif; other site 645463010087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 645463010088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010089 active site 645463010090 phosphorylation site [posttranslational modification] 645463010091 intermolecular recognition site; other site 645463010092 dimerization interface [polypeptide binding]; other site 645463010093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 645463010094 DNA binding residues [nucleotide binding] 645463010095 dimerization interface [polypeptide binding]; other site 645463010096 Homeodomain-like domain; Region: HTH_23; pfam13384 645463010097 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 645463010098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463010099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463010100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463010101 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463010102 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 645463010103 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645463010104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010105 Walker A/P-loop; other site 645463010106 ATP binding site [chemical binding]; other site 645463010107 Q-loop/lid; other site 645463010108 ABC transporter signature motif; other site 645463010109 Walker B; other site 645463010110 D-loop; other site 645463010111 H-loop/switch region; other site 645463010112 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 645463010113 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463010114 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 645463010115 DNA binding residues [nucleotide binding] 645463010116 putative dimer interface [polypeptide binding]; other site 645463010117 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 645463010118 DNA binding residues [nucleotide binding] 645463010119 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463010120 dimer interface [polypeptide binding]; other site 645463010121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463010122 H+ Antiporter protein; Region: 2A0121; TIGR00900 645463010123 putative substrate translocation pore; other site 645463010124 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463010125 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463010126 Acyltransferase family; Region: Acyl_transf_3; cl19154 645463010127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463010128 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463010129 Walker A/P-loop; other site 645463010130 ATP binding site [chemical binding]; other site 645463010131 Q-loop/lid; other site 645463010132 ABC transporter signature motif; other site 645463010133 Walker B; other site 645463010134 D-loop; other site 645463010135 H-loop/switch region; other site 645463010136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463010137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 645463010138 dimerization interface [polypeptide binding]; other site 645463010139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463010140 dimer interface [polypeptide binding]; other site 645463010141 phosphorylation site [posttranslational modification] 645463010142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463010143 ATP binding site [chemical binding]; other site 645463010144 Mg2+ binding site [ion binding]; other site 645463010145 G-X-G motif; other site 645463010146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010148 active site 645463010149 phosphorylation site [posttranslational modification] 645463010150 intermolecular recognition site; other site 645463010151 dimerization interface [polypeptide binding]; other site 645463010152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010153 DNA binding site [nucleotide binding] 645463010154 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 645463010155 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463010156 FMN binding site [chemical binding]; other site 645463010157 dimer interface [polypeptide binding]; other site 645463010158 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463010159 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463010160 Transcriptional regulators [Transcription]; Region: MarR; COG1846 645463010161 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 645463010162 Predicted transcriptional regulators [Transcription]; Region: COG1695 645463010163 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463010164 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 645463010165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463010166 S-adenosylmethionine binding site [chemical binding]; other site 645463010167 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 645463010168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463010169 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463010170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010171 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 645463010172 Walker A/P-loop; other site 645463010173 ATP binding site [chemical binding]; other site 645463010174 Q-loop/lid; other site 645463010175 ABC transporter signature motif; other site 645463010176 Walker B; other site 645463010177 D-loop; other site 645463010178 H-loop/switch region; other site 645463010179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463010180 dimer interface [polypeptide binding]; other site 645463010181 conserved gate region; other site 645463010182 putative PBP binding loops; other site 645463010183 ABC-ATPase subunit interface; other site 645463010184 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 645463010185 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 645463010186 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645463010187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010188 Walker A/P-loop; other site 645463010189 ATP binding site [chemical binding]; other site 645463010190 Q-loop/lid; other site 645463010191 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 645463010192 ABC transporter signature motif; other site 645463010193 Walker B; other site 645463010194 D-loop; other site 645463010195 H-loop/switch region; other site 645463010196 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 645463010197 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 645463010198 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 645463010199 dimerization interface [polypeptide binding]; other site 645463010200 domain crossover interface; other site 645463010201 redox-dependent activation switch; other site 645463010202 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 645463010203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463010204 S-adenosylmethionine binding site [chemical binding]; other site 645463010205 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 645463010206 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645463010207 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 645463010208 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 645463010209 metal binding site [ion binding]; metal-binding site 645463010210 dimer interface [polypeptide binding]; other site 645463010211 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 645463010212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 645463010213 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 645463010214 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 645463010215 dimer interface [polypeptide binding]; other site 645463010216 active site 645463010217 catalytic residue [active] 645463010218 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 645463010219 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 645463010220 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 645463010221 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 645463010222 dimer interface [polypeptide binding]; other site 645463010223 active site 645463010224 catalytic residue [active] 645463010225 dihydrodipicolinate reductase; Provisional; Region: PRK00048 645463010226 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 645463010227 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 645463010228 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 645463010229 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 645463010230 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 645463010231 active site 645463010232 trimer interface [polypeptide binding]; other site 645463010233 substrate binding site [chemical binding]; other site 645463010234 CoA binding site [chemical binding]; other site 645463010235 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 645463010236 putative CoA binding site [chemical binding]; other site 645463010237 putative trimer interface [polypeptide binding]; other site 645463010238 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 645463010239 prohibitin homologues; Region: PHB; smart00244 645463010240 dihydrodipicolinate reductase; Provisional; Region: PRK00048 645463010241 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 645463010242 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 645463010243 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010244 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010245 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010246 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010247 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463010249 active site 645463010250 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 645463010251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010252 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463010253 Walker A motif; other site 645463010254 ATP binding site [chemical binding]; other site 645463010255 Walker B motif; other site 645463010256 arginine finger; other site 645463010257 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463010258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463010259 single-stranded DNA-binding protein; Provisional; Region: PRK05813 645463010260 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645463010261 dimer interface [polypeptide binding]; other site 645463010262 ssDNA binding site [nucleotide binding]; other site 645463010263 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463010264 Predicted permeases [General function prediction only]; Region: COG0730 645463010265 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 645463010266 proline racemase; Provisional; Region: PRK13969 645463010267 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 645463010268 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 645463010269 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 645463010270 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 645463010271 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 645463010272 FOG: CBS domain [General function prediction only]; Region: COG0517 645463010273 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_13; cd04626 645463010274 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 645463010275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010276 Walker A motif; other site 645463010277 ATP binding site [chemical binding]; other site 645463010278 Walker B motif; other site 645463010279 arginine finger; other site 645463010280 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 645463010281 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 645463010282 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 645463010283 SLBB domain; Region: SLBB; pfam10531 645463010284 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 645463010285 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 645463010286 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 645463010287 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 645463010288 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 645463010289 TSCPD domain; Region: TSCPD; cl14834 645463010290 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 645463010291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645463010292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645463010293 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 645463010294 Subtilase family; Region: Peptidase_S8; pfam00082 645463010295 active site 645463010296 catalytic triad [active] 645463010297 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463010298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010299 active site 645463010300 phosphorylation site [posttranslational modification] 645463010301 intermolecular recognition site; other site 645463010302 dimerization interface [polypeptide binding]; other site 645463010303 LytTr DNA-binding domain; Region: LytTR; smart00850 645463010304 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 645463010305 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 645463010306 active site 645463010307 HIGH motif; other site 645463010308 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 645463010309 KMSKS motif; other site 645463010310 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 645463010311 tRNA binding surface [nucleotide binding]; other site 645463010312 anticodon binding site; other site 645463010313 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 645463010314 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 645463010315 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 645463010316 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 645463010317 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 645463010318 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 645463010319 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 645463010320 PhoU domain; Region: PhoU; pfam01895 645463010321 PhoU domain; Region: PhoU; pfam01895 645463010322 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 645463010323 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 645463010324 Walker A/P-loop; other site 645463010325 ATP binding site [chemical binding]; other site 645463010326 Q-loop/lid; other site 645463010327 ABC transporter signature motif; other site 645463010328 Walker B; other site 645463010329 D-loop; other site 645463010330 H-loop/switch region; other site 645463010331 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 645463010332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463010333 dimer interface [polypeptide binding]; other site 645463010334 conserved gate region; other site 645463010335 putative PBP binding loops; other site 645463010336 ABC-ATPase subunit interface; other site 645463010337 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 645463010338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463010339 dimer interface [polypeptide binding]; other site 645463010340 conserved gate region; other site 645463010341 putative PBP binding loops; other site 645463010342 ABC-ATPase subunit interface; other site 645463010343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463010344 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 645463010345 Walker A/P-loop; other site 645463010346 ATP binding site [chemical binding]; other site 645463010347 Q-loop/lid; other site 645463010348 ABC transporter signature motif; other site 645463010349 Walker B; other site 645463010350 D-loop; other site 645463010351 H-loop/switch region; other site 645463010352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463010353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463010354 dimer interface [polypeptide binding]; other site 645463010355 phosphorylation site [posttranslational modification] 645463010356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463010357 ATP binding site [chemical binding]; other site 645463010358 Mg2+ binding site [ion binding]; other site 645463010359 G-X-G motif; other site 645463010360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010362 active site 645463010363 phosphorylation site [posttranslational modification] 645463010364 intermolecular recognition site; other site 645463010365 dimerization interface [polypeptide binding]; other site 645463010366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010367 DNA binding site [nucleotide binding] 645463010368 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010370 active site 645463010371 phosphorylation site [posttranslational modification] 645463010372 intermolecular recognition site; other site 645463010373 dimerization interface [polypeptide binding]; other site 645463010374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010375 DNA binding site [nucleotide binding] 645463010376 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 645463010377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 645463010378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463010379 dimer interface [polypeptide binding]; other site 645463010380 phosphorylation site [posttranslational modification] 645463010381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463010382 ATP binding site [chemical binding]; other site 645463010383 Mg2+ binding site [ion binding]; other site 645463010384 G-X-G motif; other site 645463010385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010387 active site 645463010388 phosphorylation site [posttranslational modification] 645463010389 intermolecular recognition site; other site 645463010390 dimerization interface [polypeptide binding]; other site 645463010391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010392 DNA binding site [nucleotide binding] 645463010393 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 645463010394 oligoendopeptidase F; Region: pepF; TIGR00181 645463010395 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 645463010396 active site 645463010397 Zn binding site [ion binding]; other site 645463010398 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 645463010399 MgtC family; Region: MgtC; pfam02308 645463010400 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 645463010401 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 645463010402 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 645463010403 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 645463010404 G1 box; other site 645463010405 GTP/Mg2+ binding site [chemical binding]; other site 645463010406 Switch I region; other site 645463010407 G2 box; other site 645463010408 G3 box; other site 645463010409 Switch II region; other site 645463010410 G4 box; other site 645463010411 G5 box; other site 645463010412 Nucleoside recognition; Region: Gate; pfam07670 645463010413 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 645463010414 Nucleoside recognition; Region: Gate; pfam07670 645463010415 Virus attachment protein p12 family; Region: P12; pfam12669 645463010416 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 645463010417 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 645463010418 dimer interface [polypeptide binding]; other site 645463010419 active site 645463010420 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 645463010421 dimer interface [polypeptide binding]; other site 645463010422 active site 645463010423 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 645463010424 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 645463010425 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463010426 active pocket/dimerization site; other site 645463010427 active site 645463010428 phosphorylation site [posttranslational modification] 645463010429 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 645463010430 active site 645463010431 phosphorylation site [posttranslational modification] 645463010432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010433 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 645463010434 Walker A motif; other site 645463010435 ATP binding site [chemical binding]; other site 645463010436 Walker B motif; other site 645463010437 arginine finger; other site 645463010438 Transcriptional antiterminator [Transcription]; Region: COG3933 645463010439 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 645463010440 active pocket/dimerization site; other site 645463010441 active site 645463010442 phosphorylation site [posttranslational modification] 645463010443 PRD domain; Region: PRD; pfam00874 645463010444 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 645463010445 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 645463010446 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 645463010447 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 645463010448 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 645463010449 dimer interface [polypeptide binding]; other site 645463010450 active site 645463010451 glycine loop; other site 645463010452 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 645463010453 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463010454 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 645463010455 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 645463010456 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 645463010457 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 645463010458 protein binding site [polypeptide binding]; other site 645463010459 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 645463010460 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 645463010461 active site 645463010462 dimer interface [polypeptide binding]; other site 645463010463 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 645463010464 dimer interface [polypeptide binding]; other site 645463010465 active site 645463010466 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 645463010467 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645463010468 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 645463010469 PhoU domain; Region: PhoU; pfam01895 645463010470 PhoU domain; Region: PhoU; pfam01895 645463010471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 645463010472 SEC-C motif; Region: SEC-C; pfam02810 645463010473 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 645463010474 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 645463010475 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 645463010476 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 645463010477 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645463010478 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645463010479 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 645463010480 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 645463010481 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 645463010482 Walker A motif; other site 645463010483 ATP binding site [chemical binding]; other site 645463010484 Walker B motif; other site 645463010485 Sec1 family; Region: Sec1; cl15415 645463010486 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 645463010487 hypothetical protein; Provisional; Region: PRK06851 645463010488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010489 Walker A motif; other site 645463010490 ATP binding site [chemical binding]; other site 645463010491 Walker B motif; other site 645463010492 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 645463010493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463010494 putative substrate translocation pore; other site 645463010495 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 645463010496 G1 box; other site 645463010497 GTP/Mg2+ binding site [chemical binding]; other site 645463010498 Switch I region; other site 645463010499 G2 box; other site 645463010500 G3 box; other site 645463010501 Switch II region; other site 645463010502 G4 box; other site 645463010503 G5 box; other site 645463010504 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 645463010505 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 645463010506 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 645463010507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010508 Walker A motif; other site 645463010509 ATP binding site [chemical binding]; other site 645463010510 Walker B motif; other site 645463010511 arginine finger; other site 645463010512 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 645463010513 Chromate transporter; Region: Chromate_transp; pfam02417 645463010514 Chromate transporter; Region: Chromate_transp; pfam02417 645463010515 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 645463010516 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 645463010517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463010518 Walker A motif; other site 645463010519 ATP binding site [chemical binding]; other site 645463010520 Walker B motif; other site 645463010521 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 645463010522 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 645463010523 oligomer interface [polypeptide binding]; other site 645463010524 active site residues [active] 645463010525 trigger factor; Provisional; Region: tig; PRK01490 645463010526 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 645463010527 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 645463010528 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 645463010529 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 645463010530 active site 645463010531 metal binding site [ion binding]; metal-binding site 645463010532 homotetramer interface [polypeptide binding]; other site 645463010533 ribonuclease PH; Reviewed; Region: rph; PRK00173 645463010534 Ribonuclease PH; Region: RNase_PH_bact; cd11362 645463010535 hexamer interface [polypeptide binding]; other site 645463010536 active site 645463010537 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 645463010538 active site 645463010539 dimerization interface [polypeptide binding]; other site 645463010540 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 645463010541 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 645463010542 nucleotide binding pocket [chemical binding]; other site 645463010543 K-X-D-G motif; other site 645463010544 catalytic site [active] 645463010545 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 645463010546 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 645463010547 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 645463010548 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 645463010549 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 645463010550 Dimer interface [polypeptide binding]; other site 645463010551 BRCT sequence motif; other site 645463010552 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 645463010553 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 645463010554 putative ligand binding site [chemical binding]; other site 645463010555 NAD binding site [chemical binding]; other site 645463010556 catalytic site [active] 645463010557 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 645463010558 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 645463010559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463010560 putative substrate translocation pore; other site 645463010561 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 645463010562 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463010563 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 645463010564 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463010565 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 645463010566 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 645463010567 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 645463010568 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463010569 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 645463010570 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 645463010571 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 645463010572 [4Fe-4S] binding site [ion binding]; other site 645463010573 molybdopterin cofactor binding site; other site 645463010574 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 645463010575 molybdopterin cofactor binding site; other site 645463010576 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 645463010577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010579 active site 645463010580 phosphorylation site [posttranslational modification] 645463010581 intermolecular recognition site; other site 645463010582 dimerization interface [polypeptide binding]; other site 645463010583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010584 DNA binding site [nucleotide binding] 645463010585 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 645463010586 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 645463010587 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 645463010588 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463010589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010590 Walker A/P-loop; other site 645463010591 ATP binding site [chemical binding]; other site 645463010592 Q-loop/lid; other site 645463010593 ABC transporter signature motif; other site 645463010594 Walker B; other site 645463010595 D-loop; other site 645463010596 H-loop/switch region; other site 645463010597 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 645463010598 Accessory gene regulator B; Region: AgrB; pfam04647 645463010599 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 645463010600 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 645463010601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463010602 ATP binding site [chemical binding]; other site 645463010603 Mg2+ binding site [ion binding]; other site 645463010604 G-X-G motif; other site 645463010605 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 645463010606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010607 active site 645463010608 phosphorylation site [posttranslational modification] 645463010609 intermolecular recognition site; other site 645463010610 dimerization interface [polypeptide binding]; other site 645463010611 LytTr DNA-binding domain; Region: LytTR; smart00850 645463010612 Protein of unknown function (DUF1062); Region: DUF1062; pfam06353 645463010613 Mor transcription activator family; Region: Mor; cl02360 645463010614 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 645463010615 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010616 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 645463010617 BclB C-terminal domain; Region: exospore_TM; TIGR03721 645463010618 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 645463010619 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 645463010620 putative metal binding site; other site 645463010621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463010622 binding surface 645463010623 TPR motif; other site 645463010624 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 645463010625 oligomer interface [polypeptide binding]; other site 645463010626 active site residues [active] 645463010627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 645463010628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 645463010629 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 645463010630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463010631 DNA-binding site [nucleotide binding]; DNA binding site 645463010632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463010633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463010634 homodimer interface [polypeptide binding]; other site 645463010635 catalytic residue [active] 645463010636 B3/4 domain; Region: B3_4; cl19243 645463010637 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 645463010638 putative FMN binding site [chemical binding]; other site 645463010639 Predicted transcriptional regulators [Transcription]; Region: COG1733 645463010640 DJ-1 family protein; Region: not_thiJ; TIGR01383 645463010641 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 645463010642 conserved cys residue [active] 645463010643 AsnC-family transcriptional regulator fragment 645463010644 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 645463010645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463010646 ABC transporter; Region: ABC_tran_2; pfam12848 645463010647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 645463010648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463010649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463010650 active site 645463010651 phosphorylation site [posttranslational modification] 645463010652 intermolecular recognition site; other site 645463010653 dimerization interface [polypeptide binding]; other site 645463010654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463010655 DNA binding site [nucleotide binding] 645463010656 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 645463010657 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 645463010658 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 645463010659 ABC-2 type transporter; Region: ABC2_membrane; cl17235 645463010660 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463010661 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 645463010662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010663 Walker A/P-loop; other site 645463010664 ATP binding site [chemical binding]; other site 645463010665 Q-loop/lid; other site 645463010666 ABC transporter signature motif; other site 645463010667 Walker B; other site 645463010668 D-loop; other site 645463010669 H-loop/switch region; other site 645463010670 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 645463010671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 645463010672 metal binding site [ion binding]; metal-binding site 645463010673 active site 645463010674 I-site; other site 645463010675 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 645463010676 GTPase RsgA; Reviewed; Region: PRK01889 645463010677 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 645463010678 RNA binding site [nucleotide binding]; other site 645463010679 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 645463010680 GTPase/Zn-binding domain interface [polypeptide binding]; other site 645463010681 GTP/Mg2+ binding site [chemical binding]; other site 645463010682 G4 box; other site 645463010683 G5 box; other site 645463010684 G1 box; other site 645463010685 Switch I region; other site 645463010686 G2 box; other site 645463010687 G3 box; other site 645463010688 Switch II region; other site 645463010689 RNHCP domain; Region: RNHCP; pfam12647 645463010690 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 645463010691 TRAM domain; Region: TRAM; cl01282 645463010692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463010693 S-adenosylmethionine binding site [chemical binding]; other site 645463010694 pyruvate kinase; Provisional; Region: PRK06354 645463010695 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 645463010696 domain interfaces; other site 645463010697 active site 645463010698 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 645463010699 6-phosphofructokinase; Provisional; Region: PRK03202 645463010700 active site 645463010701 ADP/pyrophosphate binding site [chemical binding]; other site 645463010702 dimerization interface [polypeptide binding]; other site 645463010703 allosteric effector site; other site 645463010704 fructose-1,6-bisphosphate binding site; other site 645463010705 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 645463010706 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 645463010707 active site 645463010708 PHP Thumb interface [polypeptide binding]; other site 645463010709 metal binding site [ion binding]; metal-binding site 645463010710 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 645463010711 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 645463010712 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 645463010713 generic binding surface II; other site 645463010714 generic binding surface I; other site 645463010715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 645463010716 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 645463010717 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 645463010718 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 645463010719 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 645463010720 active site 645463010721 Ap6A binding site [chemical binding]; other site 645463010722 nudix motif; other site 645463010723 metal binding site [ion binding]; metal-binding site 645463010724 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 645463010725 phosphate binding site [ion binding]; other site 645463010726 putative substrate binding pocket [chemical binding]; other site 645463010727 dimer interface [polypeptide binding]; other site 645463010728 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 645463010729 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 645463010730 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 645463010731 active site 645463010732 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 645463010733 FAD binding domain; Region: FAD_binding_4; pfam01565 645463010734 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 645463010735 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 645463010736 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 645463010737 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 645463010738 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 645463010739 putative active site [active] 645463010740 catalytic site [active] 645463010741 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 645463010742 putative active site [active] 645463010743 catalytic site [active] 645463010744 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 645463010745 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 645463010746 putative dimer interface [polypeptide binding]; other site 645463010747 [2Fe-2S] cluster binding site [ion binding]; other site 645463010748 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 645463010749 dimer interface [polypeptide binding]; other site 645463010750 [2Fe-2S] cluster binding site [ion binding]; other site 645463010751 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 645463010752 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 645463010753 SLBB domain; Region: SLBB; pfam10531 645463010754 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 645463010755 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 645463010756 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 645463010757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 645463010758 catalytic loop [active] 645463010759 iron binding site [ion binding]; other site 645463010760 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 645463010761 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 645463010762 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 645463010763 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 645463010764 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 645463010765 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 645463010766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463010767 Walker A/P-loop; other site 645463010768 ATP binding site [chemical binding]; other site 645463010769 Q-loop/lid; other site 645463010770 ABC transporter signature motif; other site 645463010771 Walker B; other site 645463010772 D-loop; other site 645463010773 H-loop/switch region; other site 645463010774 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 645463010775 HPr kinase/phosphorylase; Provisional; Region: PRK05428 645463010776 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 645463010777 Hpr binding site; other site 645463010778 active site 645463010779 homohexamer subunit interaction site [polypeptide binding]; other site 645463010780 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 645463010781 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 645463010782 GIY-YIG motif/motif A; other site 645463010783 active site 645463010784 catalytic site [active] 645463010785 putative DNA binding site [nucleotide binding]; other site 645463010786 metal binding site [ion binding]; metal-binding site 645463010787 UvrB/uvrC motif; Region: UVR; pfam02151 645463010788 SPRY domain; Region: SPRY; cl02614 645463010789 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 645463010790 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 645463010791 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 645463010792 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645463010793 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 645463010794 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 645463010795 excinuclease ABC subunit B; Provisional; Region: PRK05298 645463010796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463010797 ATP binding site [chemical binding]; other site 645463010798 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 645463010799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463010800 nucleotide binding region [chemical binding]; other site 645463010801 ATP-binding site [chemical binding]; other site 645463010802 Ultra-violet resistance protein B; Region: UvrB; pfam12344 645463010803 UvrB/uvrC motif; Region: UVR; pfam02151 645463010804 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 645463010805 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 645463010806 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 645463010807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463010808 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 645463010809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463010810 dimer interface [polypeptide binding]; other site 645463010811 conserved gate region; other site 645463010812 putative PBP binding loops; other site 645463010813 ABC-ATPase subunit interface; other site 645463010814 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 645463010815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463010816 dimer interface [polypeptide binding]; other site 645463010817 conserved gate region; other site 645463010818 putative PBP binding loops; other site 645463010819 ABC-ATPase subunit interface; other site 645463010820 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 645463010821 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 645463010822 Walker A/P-loop; other site 645463010823 ATP binding site [chemical binding]; other site 645463010824 Q-loop/lid; other site 645463010825 ABC transporter signature motif; other site 645463010826 Walker B; other site 645463010827 D-loop; other site 645463010828 H-loop/switch region; other site 645463010829 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 645463010830 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 645463010831 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 645463010832 dimer interface [polypeptide binding]; other site 645463010833 active site 645463010834 Schiff base residues; other site 645463010835 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 645463010836 active site 645463010837 SAM binding site [chemical binding]; other site 645463010838 homodimer interface [polypeptide binding]; other site 645463010839 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 645463010840 active site 645463010841 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 645463010842 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 645463010843 domain interfaces; other site 645463010844 active site 645463010845 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 645463010846 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 645463010847 active site 645463010848 C-terminal domain interface [polypeptide binding]; other site 645463010849 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 645463010850 active site 645463010851 N-terminal domain interface [polypeptide binding]; other site 645463010852 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 645463010853 active site 645463010854 SAM binding site [chemical binding]; other site 645463010855 homodimer interface [polypeptide binding]; other site 645463010856 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 645463010857 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 645463010858 active site 645463010859 SAM binding site [chemical binding]; other site 645463010860 homodimer interface [polypeptide binding]; other site 645463010861 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 645463010862 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 645463010863 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 645463010864 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 645463010865 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 645463010866 active site 645463010867 SAM binding site [chemical binding]; other site 645463010868 homodimer interface [polypeptide binding]; other site 645463010869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463010870 S-adenosylmethionine binding site [chemical binding]; other site 645463010871 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 645463010872 active site 645463010873 putative homodimer interface [polypeptide binding]; other site 645463010874 SAM binding site [chemical binding]; other site 645463010875 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 645463010876 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 645463010877 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 645463010878 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645463010879 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645463010880 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 645463010881 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463010882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463010883 homodimer interface [polypeptide binding]; other site 645463010884 catalytic residue [active] 645463010885 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 645463010886 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 645463010887 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 645463010888 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 645463010889 catalytic triad [active] 645463010890 cobyric acid synthase; Provisional; Region: PRK00784 645463010891 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645463010892 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 645463010893 catalytic triad [active] 645463010894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 645463010895 catalytic core [active] 645463010896 cobalamin synthase; Reviewed; Region: cobS; PRK00235 645463010897 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 645463010898 homotrimer interface [polypeptide binding]; other site 645463010899 Walker A motif; other site 645463010900 GTP binding site [chemical binding]; other site 645463010901 Walker B motif; other site 645463010902 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 645463010903 putative dimer interface [polypeptide binding]; other site 645463010904 active site pocket [active] 645463010905 putative cataytic base [active] 645463010906 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 645463010907 active site 645463010908 catalytic residues [active] 645463010909 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 645463010910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463010911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463010912 homodimer interface [polypeptide binding]; other site 645463010913 catalytic residue [active] 645463010914 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 645463010915 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 645463010916 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 645463010917 active site 645463010918 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463010919 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463010920 active site 645463010921 P-loop; other site 645463010922 phosphorylation site [posttranslational modification] 645463010923 methionine cluster; other site 645463010924 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 645463010925 active site 645463010926 phosphorylation site [posttranslational modification] 645463010927 metal binding site [ion binding]; metal-binding site 645463010928 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 645463010929 oligomer interface [polypeptide binding]; other site 645463010930 active site 645463010931 metal binding site [ion binding]; metal-binding site 645463010932 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463010933 HTH domain; Region: HTH_11; pfam08279 645463010934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 645463010935 PRD domain; Region: PRD; pfam00874 645463010936 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463010937 active site 645463010938 P-loop; other site 645463010939 phosphorylation site [posttranslational modification] 645463010940 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 645463010941 active site 645463010942 phosphorylation site [posttranslational modification] 645463010943 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 645463010944 intersubunit interface [polypeptide binding]; other site 645463010945 active site 645463010946 zinc binding site [ion binding]; other site 645463010947 Na+ binding site [ion binding]; other site 645463010948 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 645463010949 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 645463010950 dimer interface [polypeptide binding]; other site 645463010951 active site 645463010952 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 645463010953 putative active site [active] 645463010954 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 645463010955 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 645463010956 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 645463010957 putative substrate binding site [chemical binding]; other site 645463010958 putative ATP binding site [chemical binding]; other site 645463010959 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463010960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463010961 DNA-binding site [nucleotide binding]; DNA binding site 645463010962 UTRA domain; Region: UTRA; pfam07702 645463010963 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 645463010964 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 645463010965 active site 645463010966 dimer interface [polypeptide binding]; other site 645463010967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 645463010968 Transposase, Mutator family; Region: Transposase_mut; cl19537 645463010969 Putative amidase domain; Region: Amidase_6; pfam12671 645463010970 Fic family protein [Function unknown]; Region: COG3177 645463010971 Fic/DOC family; Region: Fic; pfam02661 645463010972 transcriptional regulator EutR; Provisional; Region: PRK10130 645463010973 multiple promoter invertase; Provisional; Region: mpi; PRK13413 645463010974 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 645463010975 catalytic residues [active] 645463010976 catalytic nucleophile [active] 645463010977 Presynaptic Site I dimer interface [polypeptide binding]; other site 645463010978 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 645463010979 Synaptic Flat tetramer interface [polypeptide binding]; other site 645463010980 Synaptic Site I dimer interface [polypeptide binding]; other site 645463010981 DNA binding site [nucleotide binding] 645463010982 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 645463010983 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 645463010984 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 645463010985 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 645463010986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 645463010987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 645463010988 DNA binding residues [nucleotide binding] 645463010989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 645463010990 Transposase, Mutator family; Region: Transposase_mut; cl19537 645463010991 C-terminal peptidase (prc); Region: prc; TIGR00225 645463010992 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 645463010993 protein binding site [polypeptide binding]; other site 645463010994 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 645463010995 Catalytic dyad [active] 645463010996 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 645463010997 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 645463010998 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 645463010999 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 645463011000 PYR/PP interface [polypeptide binding]; other site 645463011001 dimer interface [polypeptide binding]; other site 645463011002 TPP binding site [chemical binding]; other site 645463011003 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 645463011004 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 645463011005 TPP-binding site [chemical binding]; other site 645463011006 dimer interface [polypeptide binding]; other site 645463011007 PemK-like protein; Region: PemK; pfam02452 645463011008 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 645463011009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 645463011010 alanine racemase; Reviewed; Region: alr; PRK00053 645463011011 active site 645463011012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 645463011013 dimer interface [polypeptide binding]; other site 645463011014 substrate binding site [chemical binding]; other site 645463011015 catalytic residues [active] 645463011016 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 645463011017 FOG: CBS domain [General function prediction only]; Region: COG0517 645463011018 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 645463011019 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 645463011020 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 645463011021 gamma subunit interface [polypeptide binding]; other site 645463011022 epsilon subunit interface [polypeptide binding]; other site 645463011023 LBP interface [polypeptide binding]; other site 645463011024 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 645463011025 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645463011026 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 645463011027 alpha subunit interaction interface [polypeptide binding]; other site 645463011028 Walker A motif; other site 645463011029 ATP binding site [chemical binding]; other site 645463011030 Walker B motif; other site 645463011031 inhibitor binding site; inhibition site 645463011032 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645463011033 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 645463011034 core domain interface [polypeptide binding]; other site 645463011035 delta subunit interface [polypeptide binding]; other site 645463011036 epsilon subunit interface [polypeptide binding]; other site 645463011037 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 645463011038 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 645463011039 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 645463011040 beta subunit interaction interface [polypeptide binding]; other site 645463011041 Walker A motif; other site 645463011042 ATP binding site [chemical binding]; other site 645463011043 Walker B motif; other site 645463011044 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 645463011045 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 645463011046 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 645463011047 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 645463011048 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 645463011049 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 645463011050 ATP synthase I chain; Region: ATP_synt_I; pfam03899 645463011051 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 645463011052 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 645463011053 catalytic motif [active] 645463011054 Zn binding site [ion binding]; other site 645463011055 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 645463011056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463011057 active site 645463011058 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 645463011059 Low molecular weight phosphatase family; Region: LMWPc; cd00115 645463011060 active site 645463011061 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 645463011062 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 645463011063 ZIP Zinc transporter; Region: Zip; cl00437 645463011064 peptide chain release factor 1; Validated; Region: prfA; PRK00591 645463011065 This domain is found in peptide chain release factors; Region: PCRF; smart00937 645463011066 RF-1 domain; Region: RF-1; pfam00472 645463011067 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 645463011068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 645463011069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463011070 S-adenosylmethionine binding site [chemical binding]; other site 645463011071 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 645463011072 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 645463011073 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 645463011074 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 645463011075 transcription termination factor Rho; Provisional; Region: PRK12608 645463011076 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 645463011077 RNA binding site [nucleotide binding]; other site 645463011078 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 645463011079 multimer interface [polypeptide binding]; other site 645463011080 Walker A motif; other site 645463011081 ATP binding site [chemical binding]; other site 645463011082 Walker B motif; other site 645463011083 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 645463011084 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 645463011085 active site 645463011086 tetramer interface; other site 645463011087 oligoendopeptidase F; Region: pepF; TIGR00181 645463011088 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 645463011089 active site 645463011090 Zn binding site [ion binding]; other site 645463011091 stage II sporulation protein E; Region: spore_II_E; TIGR02865 645463011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463011093 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 645463011094 exopolyphosphatase; Region: exo_poly_only; TIGR03706 645463011095 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 645463011096 Septum formation initiator; Region: DivIC; cl17659 645463011097 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 645463011098 YabP family; Region: YabP; cl06766 645463011099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 645463011100 RNA binding surface [nucleotide binding]; other site 645463011101 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 645463011102 IHF - DNA interface [nucleotide binding]; other site 645463011103 IHF dimer interface [polypeptide binding]; other site 645463011104 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 645463011105 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 645463011106 active site 645463011107 homodimer interface [polypeptide binding]; other site 645463011108 SAM binding site [chemical binding]; other site 645463011109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 645463011110 homodimer interface [polypeptide binding]; other site 645463011111 metal binding site [ion binding]; metal-binding site 645463011112 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 645463011113 homodimer interface [polypeptide binding]; other site 645463011114 active site 645463011115 putative chemical substrate binding site [chemical binding]; other site 645463011116 metal binding site [ion binding]; metal-binding site 645463011117 stage V sporulation protein B; Region: spore_V_B; TIGR02900 645463011118 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 645463011119 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 645463011120 stage V sporulation protein T; Region: spore_V_T; TIGR02851 645463011121 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 645463011122 SurA N-terminal domain; Region: SurA_N_3; cl07813 645463011123 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 645463011124 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 645463011125 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 645463011126 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 645463011127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 645463011128 ATP binding site [chemical binding]; other site 645463011129 putative Mg++ binding site [ion binding]; other site 645463011130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 645463011131 nucleotide binding region [chemical binding]; other site 645463011132 ATP-binding site [chemical binding]; other site 645463011133 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 645463011134 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 645463011135 putative active site [active] 645463011136 catalytic residue [active] 645463011137 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 645463011138 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 645463011139 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 645463011140 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 645463011141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 645463011142 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 645463011143 Walker A motif; other site 645463011144 ATP binding site [chemical binding]; other site 645463011145 Walker B motif; other site 645463011146 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 645463011147 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 645463011148 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 645463011149 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 645463011150 Fimbrial assembly protein (PilN); Region: PilN; cl19830 645463011151 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 645463011152 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645463011153 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 645463011154 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 645463011155 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 645463011156 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 645463011157 Walker A motif; other site 645463011158 ATP binding site [chemical binding]; other site 645463011159 Walker B motif; other site 645463011160 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 645463011161 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 645463011162 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 645463011163 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 645463011164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463011165 active site 645463011166 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 645463011167 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 645463011168 Substrate binding site; other site 645463011169 Mg++ binding site; other site 645463011170 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 645463011171 active site 645463011172 substrate binding site [chemical binding]; other site 645463011173 CoA binding site [chemical binding]; other site 645463011174 regulatory protein SpoVG; Reviewed; Region: PRK13259 645463011175 pur operon repressor; Provisional; Region: PRK09213 645463011176 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 645463011177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 645463011178 active site 645463011179 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 645463011180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 645463011181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 645463011182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 645463011183 Dynein, heavy chain [Cytoskeleton]; Region: DYN1; COG5245 645463011184 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645463011185 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 645463011186 peptidase T-like protein; Region: PepT-like; TIGR01883 645463011187 metal binding site [ion binding]; metal-binding site 645463011188 putative dimer interface [polypeptide binding]; other site 645463011189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463011190 S-adenosylmethionine binding site [chemical binding]; other site 645463011191 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 645463011192 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 645463011193 putative active site [active] 645463011194 putative metal binding site [ion binding]; other site 645463011195 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 645463011196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463011197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 645463011198 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 645463011199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463011200 dimer interface [polypeptide binding]; other site 645463011201 conserved gate region; other site 645463011202 putative PBP binding loops; other site 645463011203 ABC-ATPase subunit interface; other site 645463011204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 645463011205 dimer interface [polypeptide binding]; other site 645463011206 conserved gate region; other site 645463011207 putative PBP binding loops; other site 645463011208 ABC-ATPase subunit interface; other site 645463011209 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 645463011210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463011211 Walker A/P-loop; other site 645463011212 ATP binding site [chemical binding]; other site 645463011213 Q-loop/lid; other site 645463011214 ABC transporter signature motif; other site 645463011215 Walker B; other site 645463011216 D-loop; other site 645463011217 H-loop/switch region; other site 645463011218 TOBE domain; Region: TOBE_2; pfam08402 645463011219 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 645463011220 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 645463011221 active site 645463011222 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 645463011223 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463011224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463011225 active site 645463011226 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 645463011227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463011228 Walker A/P-loop; other site 645463011229 ATP binding site [chemical binding]; other site 645463011230 Q-loop/lid; other site 645463011231 ABC transporter signature motif; other site 645463011232 Walker B; other site 645463011233 D-loop; other site 645463011234 H-loop/switch region; other site 645463011235 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 645463011236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 645463011237 Walker A/P-loop; other site 645463011238 ATP binding site [chemical binding]; other site 645463011239 Q-loop/lid; other site 645463011240 ABC transporter signature motif; other site 645463011241 Walker B; other site 645463011242 D-loop; other site 645463011243 H-loop/switch region; other site 645463011244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 645463011245 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 645463011246 Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; pfam05861 645463011247 phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292 645463011248 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 645463011249 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 645463011250 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 645463011251 active site 645463011252 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 645463011253 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 645463011254 active site 645463011255 HIGH motif; other site 645463011256 KMSKS motif; other site 645463011257 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 645463011258 tRNA binding surface [nucleotide binding]; other site 645463011259 anticodon binding site; other site 645463011260 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 645463011261 dimer interface [polypeptide binding]; other site 645463011262 putative tRNA-binding site [nucleotide binding]; other site 645463011263 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 645463011264 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 645463011265 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 645463011266 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 645463011267 active site 645463011268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 645463011269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463011270 putative DNA binding site [nucleotide binding]; other site 645463011271 putative Zn2+ binding site [ion binding]; other site 645463011272 AsnC family; Region: AsnC_trans_reg; pfam01037 645463011273 HD domain; Region: HD; pfam01966 645463011274 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 645463011275 putative SAM binding site [chemical binding]; other site 645463011276 putative homodimer interface [polypeptide binding]; other site 645463011277 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 645463011278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463011279 S-adenosylmethionine binding site [chemical binding]; other site 645463011280 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 645463011281 DNA polymerase III subunit delta'; Validated; Region: PRK05564 645463011282 DNA polymerase III subunit delta'; Validated; Region: PRK08485 645463011283 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 645463011284 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 645463011285 TMP-binding site; other site 645463011286 ATP-binding site [chemical binding]; other site 645463011287 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 645463011288 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 645463011289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463011290 catalytic residue [active] 645463011291 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 645463011292 Domain of unknown function (DUF378); Region: DUF378; pfam04070 645463011293 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 645463011294 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 645463011295 dimer interface [polypeptide binding]; other site 645463011296 putative anticodon binding site; other site 645463011297 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 645463011298 motif 1; other site 645463011299 active site 645463011300 motif 2; other site 645463011301 motif 3; other site 645463011302 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 645463011303 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 645463011304 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 645463011305 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 645463011306 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 645463011307 FMN binding site [chemical binding]; other site 645463011308 active site 645463011309 catalytic residues [active] 645463011310 substrate binding site [chemical binding]; other site 645463011311 pantothenate kinase; Reviewed; Region: PRK13318 645463011312 Predicted membrane protein [Function unknown]; Region: COG4684 645463011313 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 645463011314 putative active site pocket [active] 645463011315 cleavage site 645463011316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 645463011317 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 645463011318 putative Zn2+ binding site [ion binding]; other site 645463011319 putative DNA binding site [nucleotide binding]; other site 645463011320 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 645463011321 FtsH Extracellular; Region: FtsH_ext; pfam06480 645463011322 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 645463011323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463011324 Walker A motif; other site 645463011325 ATP binding site [chemical binding]; other site 645463011326 Walker B motif; other site 645463011327 arginine finger; other site 645463011328 Peptidase family M41; Region: Peptidase_M41; pfam01434 645463011329 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 645463011330 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 645463011331 Ligand Binding Site [chemical binding]; other site 645463011332 TilS substrate C-terminal domain; Region: TilS_C; smart00977 645463011333 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 645463011334 glutamate racemase; Provisional; Region: PRK00865 645463011335 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 645463011336 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 645463011337 Transcriptional regulators [Transcription]; Region: GntR; COG1802 645463011338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463011339 DNA-binding site [nucleotide binding]; DNA binding site 645463011340 FCD domain; Region: FCD; pfam07729 645463011341 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 645463011342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 645463011343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 645463011344 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 645463011345 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 645463011346 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 645463011347 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 645463011348 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 645463011349 YabG peptidase U57; Region: Peptidase_U57; pfam05582 645463011350 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 645463011351 active site 645463011352 dimer interface [polypeptide binding]; other site 645463011353 hypothetical protein; Provisional; Region: PRK05590 645463011354 UPF0489 domain; Region: UPF0489; pfam12640 645463011355 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 645463011356 Na binding site [ion binding]; other site 645463011357 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 645463011358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 645463011359 putative substrate translocation pore; other site 645463011360 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 645463011361 homodimer interface [polypeptide binding]; other site 645463011362 substrate-cofactor binding pocket; other site 645463011363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463011364 catalytic residue [active] 645463011365 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 645463011366 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 645463011367 catalytic residues [active] 645463011368 catalytic nucleophile [active] 645463011369 Presynaptic Site I dimer interface [polypeptide binding]; other site 645463011370 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 645463011371 Synaptic Flat tetramer interface [polypeptide binding]; other site 645463011372 Synaptic Site I dimer interface [polypeptide binding]; other site 645463011373 DNA binding site [nucleotide binding] 645463011374 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 645463011375 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 645463011376 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 645463011377 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 645463011378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463011379 S-adenosylmethionine binding site [chemical binding]; other site 645463011380 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 645463011381 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 645463011382 active site 645463011383 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645463011384 DNA binding residues [nucleotide binding] 645463011385 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 645463011386 drug binding residues [chemical binding]; other site 645463011387 dimer interface [polypeptide binding]; other site 645463011388 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 645463011389 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 645463011390 FtsX-like permease family; Region: FtsX; pfam02687 645463011391 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 645463011392 FtsX-like permease family; Region: FtsX; pfam02687 645463011393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 645463011394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 645463011395 Walker A/P-loop; other site 645463011396 ATP binding site [chemical binding]; other site 645463011397 Q-loop/lid; other site 645463011398 ABC transporter signature motif; other site 645463011399 Walker B; other site 645463011400 D-loop; other site 645463011401 H-loop/switch region; other site 645463011402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 645463011403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463011404 dimer interface [polypeptide binding]; other site 645463011405 phosphorylation site [posttranslational modification] 645463011406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463011407 ATP binding site [chemical binding]; other site 645463011408 Mg2+ binding site [ion binding]; other site 645463011409 G-X-G motif; other site 645463011410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463011411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463011412 active site 645463011413 phosphorylation site [posttranslational modification] 645463011414 intermolecular recognition site; other site 645463011415 dimerization interface [polypeptide binding]; other site 645463011416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463011417 DNA binding site [nucleotide binding] 645463011418 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 645463011419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463011420 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645463011421 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 645463011422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463011423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645463011424 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 645463011425 IMP binding site; other site 645463011426 dimer interface [polypeptide binding]; other site 645463011427 interdomain contacts; other site 645463011428 partial ornithine binding site; other site 645463011429 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 645463011430 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 645463011431 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 645463011432 catalytic site [active] 645463011433 subunit interface [polypeptide binding]; other site 645463011434 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 645463011435 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463011436 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 645463011437 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 645463011438 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 645463011439 ATP-grasp domain; Region: ATP-grasp_4; cl17255 645463011440 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 645463011441 IMP binding site; other site 645463011442 dimer interface [polypeptide binding]; other site 645463011443 interdomain contacts; other site 645463011444 partial ornithine binding site; other site 645463011445 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 645463011446 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 645463011447 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 645463011448 catalytic site [active] 645463011449 subunit interface [polypeptide binding]; other site 645463011450 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 645463011451 active site 645463011452 dimer interface [polypeptide binding]; other site 645463011453 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 645463011454 Nitroreductase family; Region: Nitroreductase; pfam00881 645463011455 FMN binding site [chemical binding]; other site 645463011456 dimer interface [polypeptide binding]; other site 645463011457 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 645463011458 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 645463011459 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 645463011460 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 645463011461 substrate binding pocket [chemical binding]; other site 645463011462 dimer interface [polypeptide binding]; other site 645463011463 inhibitor binding site; inhibition site 645463011464 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 645463011465 B12 binding site [chemical binding]; other site 645463011466 cobalt ligand [ion binding]; other site 645463011467 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 645463011468 S-ribosylhomocysteinase; Provisional; Region: PRK02260 645463011469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 645463011470 dimer interface [polypeptide binding]; other site 645463011471 phosphorylation site [posttranslational modification] 645463011472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 645463011473 ATP binding site [chemical binding]; other site 645463011474 Mg2+ binding site [ion binding]; other site 645463011475 G-X-G motif; other site 645463011476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 645463011477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 645463011478 active site 645463011479 phosphorylation site [posttranslational modification] 645463011480 intermolecular recognition site; other site 645463011481 dimerization interface [polypeptide binding]; other site 645463011482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 645463011483 DNA binding site [nucleotide binding] 645463011484 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 645463011485 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 645463011486 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 645463011487 Ligand Binding Site [chemical binding]; other site 645463011488 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 645463011489 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 645463011490 putative active site [active] 645463011491 putative metal binding site [ion binding]; other site 645463011492 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 645463011493 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 645463011494 putative NAD(P) binding site [chemical binding]; other site 645463011495 active site 645463011496 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 645463011497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 645463011498 active site 645463011499 motif I; other site 645463011500 motif II; other site 645463011501 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 645463011502 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 645463011503 dihydroorotase; Provisional; Region: PRK09237 645463011504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463011505 active site 645463011506 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 645463011507 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 645463011508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463011509 Walker A/P-loop; other site 645463011510 ATP binding site [chemical binding]; other site 645463011511 Q-loop/lid; other site 645463011512 ABC transporter signature motif; other site 645463011513 Walker B; other site 645463011514 D-loop; other site 645463011515 H-loop/switch region; other site 645463011516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 645463011517 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 645463011518 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 645463011519 MATE family multidrug exporter; Provisional; Region: PRK10189 645463011520 Staygreen protein; Region: Staygreen; pfam12638 645463011521 Protein of unknown function, DUF488; Region: DUF488; pfam04343 645463011522 Cna protein B-type domain; Region: Cna_B; pfam05738 645463011523 Cna protein B-type domain; Region: Cna_B; pfam05738 645463011524 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 645463011525 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 645463011526 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 645463011527 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 645463011528 YcxB-like protein; Region: YcxB; pfam14317 645463011529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463011530 Walker A motif; other site 645463011531 ATP binding site [chemical binding]; other site 645463011532 Walker B motif; other site 645463011533 arginine finger; other site 645463011534 Replication initiation factor; Region: Rep_trans; pfam02486 645463011535 Chloramphenicol acetyltransferase; Region: CAT; cl02008 645463011536 Antirestriction protein (ArdA); Region: ArdA; cl01953 645463011537 Antirestriction protein (ArdA); Region: ArdA; pfam07275 645463011538 AAA-like domain; Region: AAA_10; pfam12846 645463011539 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 645463011540 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 645463011541 Lysozyme-like; Region: Lysozyme_like; pfam13702 645463011542 NlpC/P60 family; Region: NLPC_P60; pfam00877 645463011543 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 645463011544 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 645463011545 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 645463011546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 645463011547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 645463011548 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 645463011549 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 645463011550 Walker A/P-loop; other site 645463011551 ATP binding site [chemical binding]; other site 645463011552 Q-loop/lid; other site 645463011553 ABC transporter signature motif; other site 645463011554 Walker B; other site 645463011555 D-loop; other site 645463011556 H-loop/switch region; other site 645463011557 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 645463011558 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 645463011559 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 645463011560 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 645463011561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 645463011562 active site 645463011563 DNA binding site [nucleotide binding] 645463011564 Int/Topo IB signature motif; other site 645463011565 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 645463011566 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 645463011567 DNA binding residues [nucleotide binding] 645463011568 drug binding residues [chemical binding]; other site 645463011569 dimer interface [polypeptide binding]; other site 645463011570 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 645463011571 potassium/proton antiporter; Reviewed; Region: PRK05326 645463011572 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 645463011573 TrkA-C domain; Region: TrkA_C; pfam02080 645463011574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 645463011575 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 645463011576 Probable transposase; Region: OrfB_IS605; pfam01385 645463011577 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 645463011578 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 645463011579 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 645463011580 dimer interface [polypeptide binding]; other site 645463011581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 645463011582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 645463011583 Coenzyme A binding pocket [chemical binding]; other site 645463011584 YmaF family; Region: YmaF; pfam12788 645463011585 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 645463011586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 645463011587 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 645463011588 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 645463011589 PhnA protein; Region: PhnA; pfam03831 645463011590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 645463011591 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 645463011592 Walker A/P-loop; other site 645463011593 ATP binding site [chemical binding]; other site 645463011594 Q-loop/lid; other site 645463011595 ABC transporter signature motif; other site 645463011596 Walker B; other site 645463011597 D-loop; other site 645463011598 H-loop/switch region; other site 645463011599 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 645463011600 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 645463011601 Entner-Doudoroff aldolase; Region: eda; TIGR01182 645463011602 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 645463011603 active site 645463011604 intersubunit interface [polypeptide binding]; other site 645463011605 catalytic residue [active] 645463011606 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 645463011607 inhibitor site; inhibition site 645463011608 active site 645463011609 dimer interface [polypeptide binding]; other site 645463011610 catalytic residue [active] 645463011611 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 645463011612 putative active site [active] 645463011613 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 645463011614 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 645463011615 active site 645463011616 P-loop; other site 645463011617 phosphorylation site [posttranslational modification] 645463011618 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 645463011619 Mga helix-turn-helix domain; Region: Mga; pfam05043 645463011620 PRD domain; Region: PRD; pfam00874 645463011621 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 645463011622 active site 645463011623 P-loop; other site 645463011624 phosphorylation site [posttranslational modification] 645463011625 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 645463011626 active site 645463011627 phosphorylation site [posttranslational modification] 645463011628 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 645463011629 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 645463011630 Uncharacterized conserved protein [Function unknown]; Region: COG5276 645463011631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 645463011632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 645463011633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 645463011634 dimerization interface [polypeptide binding]; other site 645463011635 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 645463011636 substrate binding site [chemical binding]; other site 645463011637 ATP binding site [chemical binding]; other site 645463011638 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 645463011639 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 645463011640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463011641 catalytic residue [active] 645463011642 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 645463011643 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 645463011644 active site 645463011645 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 645463011646 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463011647 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 645463011648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 645463011649 DNA-binding site [nucleotide binding]; DNA binding site 645463011650 UTRA domain; Region: UTRA; cl17743 645463011651 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 645463011652 active site 645463011653 methionine cluster; other site 645463011654 phosphorylation site [posttranslational modification] 645463011655 metal binding site [ion binding]; metal-binding site 645463011656 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 645463011657 active site 645463011658 P-loop; other site 645463011659 phosphorylation site [posttranslational modification] 645463011660 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 645463011661 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 645463011662 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 645463011663 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 645463011664 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 645463011665 Zn binding site [ion binding]; other site 645463011666 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 645463011667 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 645463011668 DNA replication protein DnaC; Validated; Region: PRK06835 645463011669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 645463011670 Walker A motif; other site 645463011671 ATP binding site [chemical binding]; other site 645463011672 Walker B motif; other site 645463011673 arginine finger; other site 645463011674 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 645463011675 GDP-binding site [chemical binding]; other site 645463011676 ACT binding site; other site 645463011677 IMP binding site; other site 645463011678 replicative DNA helicase; Region: DnaB; TIGR00665 645463011679 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 645463011680 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 645463011681 Walker A motif; other site 645463011682 ATP binding site [chemical binding]; other site 645463011683 Walker B motif; other site 645463011684 DNA binding loops [nucleotide binding] 645463011685 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 645463011686 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 645463011687 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 645463011688 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 645463011689 DHH family; Region: DHH; pfam01368 645463011690 DHHA1 domain; Region: DHHA1; pfam02272 645463011691 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 645463011692 MazG-like family; Region: MazG-like; pfam12643 645463011693 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 645463011694 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 645463011695 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 645463011696 dimer interface [polypeptide binding]; other site 645463011697 ssDNA binding site [nucleotide binding]; other site 645463011698 tetramer (dimer of dimers) interface [polypeptide binding]; other site 645463011699 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 645463011700 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 645463011701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 645463011702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 645463011703 homodimer interface [polypeptide binding]; other site 645463011704 catalytic residue [active] 645463011705 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 645463011706 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 645463011707 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 645463011708 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 645463011709 CPxP motif; other site 645463011710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 645463011711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 645463011712 non-specific DNA binding site [nucleotide binding]; other site 645463011713 salt bridge; other site 645463011714 sequence-specific DNA binding site [nucleotide binding]; other site 645463011715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463011716 binding surface 645463011717 TPR motif; other site 645463011718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463011719 binding surface 645463011720 TPR motif; other site 645463011721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645463011722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645463011723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 645463011724 binding surface 645463011725 TPR motif; other site 645463011726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 645463011727 Sporulation and spore germination; Region: Germane; pfam10646 645463011728 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 645463011729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 645463011730 catalytic residue [active] 645463011731 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 645463011732 ParB-like nuclease domain; Region: ParBc; pfam02195 645463011733 KorB domain; Region: KorB; pfam08535 645463011734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 645463011735 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 645463011736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 645463011737 P-loop; other site 645463011738 Magnesium ion binding site [ion binding]; other site 645463011739 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 645463011740 ParB-like nuclease domain; Region: ParB; smart00470 645463011741 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 645463011742 Methyltransferase domain; Region: Methyltransf_31; pfam13847 645463011743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 645463011744 S-adenosylmethionine binding site [chemical binding]; other site 645463011745 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 645463011746 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 645463011747 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 645463011748 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 645463011749 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 645463011750 Protein of unknown function (DUF677); Region: DUF677; pfam05055 645463011751 trmE is a tRNA modification GTPase; Region: trmE; cd04164 645463011752 G1 box; other site 645463011753 GTP/Mg2+ binding site [chemical binding]; other site 645463011754 Switch I region; other site 645463011755 G2 box; other site 645463011756 Switch II region; other site 645463011757 G3 box; other site 645463011758 G4 box; other site 645463011759 G5 box; other site 645463011760 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 645463011761 Jag N-terminus; Region: Jag_N; pfam14804 645463011762 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 645463011763 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 645463011764 G-X-X-G motif; other site 645463011765 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 645463011766 RxxxH motif; other site 645463011767 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 645463011768 Haemolytic domain; Region: Haemolytic; pfam01809 645463011769 ribonuclease P; Reviewed; Region: rnpA; PRK00499 645463011770 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399