-- dump date 20140619_044444 -- class Genbank::misc_feature -- table misc_feature_note -- id note 431943000001 CHC2 zinc finger; Region: zf-CHC2; cl17510 431943000002 ERCC4 domain; Region: ERCC4; cl10594 431943000003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 431943000004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 431943000005 non-specific DNA binding site [nucleotide binding]; other site 431943000006 salt bridge; other site 431943000007 sequence-specific DNA binding site [nucleotide binding]; other site 431943000008 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943000009 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943000010 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 431943000011 homodimer interface [polypeptide binding]; other site 431943000012 metal binding site [ion binding]; metal-binding site 431943000013 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 431943000014 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 431943000015 dimer interface [polypeptide binding]; other site 431943000016 ssDNA binding site [nucleotide binding]; other site 431943000017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 431943000018 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 431943000019 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943000020 active site 431943000021 metal binding site [ion binding]; metal-binding site 431943000022 DNA binding site [nucleotide binding] 431943000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000024 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 431943000025 Walker A/P-loop; other site 431943000026 ATP binding site [chemical binding]; other site 431943000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000028 ABC transporter signature motif; other site 431943000029 Walker B; other site 431943000030 D-loop; other site 431943000031 H-loop/switch region; other site 431943000032 Protein of unknown function (DUF555); Region: DUF555; cl00818 431943000033 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 431943000034 Homeodomain-like domain; Region: HTH_23; pfam13384 431943000035 Pleckstrin homology-like domain; Region: PH-like; cl17171 431943000036 ORF6N domain; Region: ORF6N; pfam10543 431943000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000038 non-specific DNA binding site [nucleotide binding]; other site 431943000039 salt bridge; other site 431943000040 sequence-specific DNA binding site [nucleotide binding]; other site 431943000041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943000043 non-specific DNA binding site [nucleotide binding]; other site 431943000044 salt bridge; other site 431943000045 sequence-specific DNA binding site [nucleotide binding]; other site 431943000046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000047 non-specific DNA binding site [nucleotide binding]; other site 431943000048 salt bridge; other site 431943000049 sequence-specific DNA binding site [nucleotide binding]; other site 431943000050 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 431943000051 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 431943000052 active site 431943000053 catalytic site [active] 431943000054 substrate binding site [chemical binding]; other site 431943000055 Helix-turn-helix domain; Region: HTH_36; pfam13730 431943000056 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 431943000057 YcfA-like protein; Region: YcfA; pfam07927 431943000058 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 431943000059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 431943000060 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 431943000061 nucleotide binding site [chemical binding]; other site 431943000062 putative protofilament interface [polypeptide binding]; other site 431943000063 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943000064 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 431943000065 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 431943000066 active site 431943000067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943000068 Holin family; Region: Phage_holin_4; pfam05105 431943000069 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 431943000070 Phage tail protein; Region: Sipho_tail; pfam05709 431943000071 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 431943000072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 431943000073 N-acetyl-D-glucosamine binding site [chemical binding]; other site 431943000074 catalytic residue [active] 431943000075 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 431943000076 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 431943000077 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943000078 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 431943000079 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 431943000080 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 431943000081 oligomerization interface [polypeptide binding]; other site 431943000082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 431943000083 Interdomain contacts; other site 431943000084 Cytokine receptor motif; other site 431943000085 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 431943000086 Phage capsid family; Region: Phage_capsid; pfam05065 431943000087 Clp protease; Region: CLP_protease; pfam00574 431943000088 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 431943000089 oligomer interface [polypeptide binding]; other site 431943000090 active site residues [active] 431943000091 Phage-related protein [Function unknown]; Region: COG4695 431943000092 Phage portal protein; Region: Phage_portal; pfam04860 431943000093 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 431943000094 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 431943000095 Phage Terminase; Region: Terminase_1; pfam03354 431943000096 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 431943000097 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 431943000098 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 431943000099 active site 431943000100 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 431943000101 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 431943000102 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 431943000103 DnaA N-terminal domain; Region: DnaA_N; pfam11638 431943000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943000105 Walker A motif; other site 431943000106 ATP binding site [chemical binding]; other site 431943000107 Walker B motif; other site 431943000108 arginine finger; other site 431943000109 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 431943000110 DnaA box-binding interface [nucleotide binding]; other site 431943000111 DNA polymerase III subunit beta; Validated; Region: PRK05643 431943000112 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 431943000113 putative DNA binding surface [nucleotide binding]; other site 431943000114 dimer interface [polypeptide binding]; other site 431943000115 beta-clamp/clamp loader binding surface; other site 431943000116 beta-clamp/translesion DNA polymerase binding surface; other site 431943000117 S4 domain; Region: S4_2; pfam13275 431943000118 recombination protein F; Reviewed; Region: recF; PRK00064 431943000119 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 431943000120 Walker A/P-loop; other site 431943000121 ATP binding site [chemical binding]; other site 431943000122 Q-loop/lid; other site 431943000123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000124 ABC transporter signature motif; other site 431943000125 Walker B; other site 431943000126 D-loop; other site 431943000127 H-loop/switch region; other site 431943000128 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 431943000129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943000130 Mg2+ binding site [ion binding]; other site 431943000131 G-X-G motif; other site 431943000132 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 431943000133 anchoring element; other site 431943000134 dimer interface [polypeptide binding]; other site 431943000135 ATP binding site [chemical binding]; other site 431943000136 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 431943000137 active site 431943000138 putative metal-binding site [ion binding]; other site 431943000139 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 431943000140 DNA gyrase subunit A; Validated; Region: PRK05560 431943000141 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 431943000142 CAP-like domain; other site 431943000143 active site 431943000144 primary dimer interface [polypeptide binding]; other site 431943000145 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000147 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000148 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000149 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943000151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943000152 Zn2+ binding site [ion binding]; other site 431943000153 Mg2+ binding site [ion binding]; other site 431943000154 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 431943000155 HTH domain; Region: HTH_11; pfam08279 431943000156 3H domain; Region: 3H; pfam02829 431943000157 hypothetical protein; Validated; Region: PRK00068 431943000158 Uncharacterized conserved protein [Function unknown]; Region: COG1615 431943000159 hydroxyglutarate oxidase; Provisional; Region: PRK11728 431943000160 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 431943000161 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 431943000162 seryl-tRNA synthetase; Provisional; Region: PRK05431 431943000163 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 431943000164 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 431943000165 dimer interface [polypeptide binding]; other site 431943000166 active site 431943000167 motif 1; other site 431943000168 motif 2; other site 431943000169 motif 3; other site 431943000170 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943000171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943000172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943000173 active site 431943000174 phosphorylation site [posttranslational modification] 431943000175 intermolecular recognition site; other site 431943000176 dimerization interface [polypeptide binding]; other site 431943000177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943000178 DNA binding site [nucleotide binding] 431943000179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943000180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943000181 dimer interface [polypeptide binding]; other site 431943000182 phosphorylation site [posttranslational modification] 431943000183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943000184 ATP binding site [chemical binding]; other site 431943000185 Mg2+ binding site [ion binding]; other site 431943000186 G-X-G motif; other site 431943000187 VanZ like family; Region: VanZ; pfam04892 431943000188 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 431943000189 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 431943000190 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 431943000191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943000192 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943000193 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943000194 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 431943000195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943000196 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 431943000197 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 431943000198 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 431943000199 putative active site [active] 431943000200 putative NTP binding site [chemical binding]; other site 431943000201 putative nucleic acid binding site [nucleotide binding]; other site 431943000202 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 431943000203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000204 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 431943000205 Walker A/P-loop; other site 431943000206 ATP binding site [chemical binding]; other site 431943000207 Q-loop/lid; other site 431943000208 ABC transporter signature motif; other site 431943000209 Walker B; other site 431943000210 D-loop; other site 431943000211 H-loop/switch region; other site 431943000212 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 431943000213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943000214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943000215 dimerization interface [polypeptide binding]; other site 431943000216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943000217 dimer interface [polypeptide binding]; other site 431943000218 phosphorylation site [posttranslational modification] 431943000219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943000220 ATP binding site [chemical binding]; other site 431943000221 Mg2+ binding site [ion binding]; other site 431943000222 G-X-G motif; other site 431943000223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943000225 active site 431943000226 phosphorylation site [posttranslational modification] 431943000227 intermolecular recognition site; other site 431943000228 dimerization interface [polypeptide binding]; other site 431943000229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943000230 DNA binding site [nucleotide binding] 431943000231 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 431943000232 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943000233 putative active site [active] 431943000234 putative metal binding site [ion binding]; other site 431943000235 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 431943000236 GtrA-like protein; Region: GtrA; pfam04138 431943000237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943000238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943000239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943000240 dimerization interface [polypeptide binding]; other site 431943000241 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 431943000242 dimer interface [polypeptide binding]; other site 431943000243 active site 431943000244 citrylCoA binding site [chemical binding]; other site 431943000245 Citrate synthase; Region: Citrate_synt; pfam00285 431943000246 oxalacetate/citrate binding site [chemical binding]; other site 431943000247 coenzyme A binding site [chemical binding]; other site 431943000248 catalytic triad [active] 431943000249 EcsC protein family; Region: EcsC; pfam12787 431943000250 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 431943000251 2-isopropylmalate synthase; Validated; Region: PRK03739 431943000252 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 431943000253 active site 431943000254 catalytic residues [active] 431943000255 metal binding site [ion binding]; metal-binding site 431943000256 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 431943000257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 431943000258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943000259 Coenzyme A binding pocket [chemical binding]; other site 431943000260 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 431943000261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943000262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943000263 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 431943000264 ABC1 family; Region: ABC1; pfam03109 431943000265 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 431943000266 active site 431943000267 ATP binding site [chemical binding]; other site 431943000268 Uncharacterized conserved protein [Function unknown]; Region: COG3937 431943000269 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 431943000270 nucleoside/Zn binding site; other site 431943000271 dimer interface [polypeptide binding]; other site 431943000272 catalytic motif [active] 431943000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000274 non-specific DNA binding site [nucleotide binding]; other site 431943000275 salt bridge; other site 431943000276 sequence-specific DNA binding site [nucleotide binding]; other site 431943000277 Terminase small subunit; Region: Terminase_2; cl01513 431943000278 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 431943000279 Cupin domain; Region: Cupin_2; pfam07883 431943000280 phosphoenolpyruvate synthase; Validated; Region: PRK06241 431943000281 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 431943000282 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943000283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943000284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943000285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000286 Walker A/P-loop; other site 431943000287 ATP binding site [chemical binding]; other site 431943000288 Putative zinc-finger; Region: zf-HC2; pfam13490 431943000289 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943000290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943000291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943000292 DNA binding residues [nucleotide binding] 431943000293 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943000294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943000295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943000296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000297 Walker A/P-loop; other site 431943000298 ATP binding site [chemical binding]; other site 431943000299 Q-loop/lid; other site 431943000300 ABC transporter signature motif; other site 431943000301 Walker B; other site 431943000302 D-loop; other site 431943000303 H-loop/switch region; other site 431943000304 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943000305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943000307 Walker A/P-loop; other site 431943000308 ATP binding site [chemical binding]; other site 431943000309 Q-loop/lid; other site 431943000310 ABC transporter signature motif; other site 431943000311 Walker B; other site 431943000312 D-loop; other site 431943000313 H-loop/switch region; other site 431943000314 Integrase core domain; Region: rve; pfam00665 431943000315 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 431943000316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000317 non-specific DNA binding site [nucleotide binding]; other site 431943000318 salt bridge; other site 431943000319 sequence-specific DNA binding site [nucleotide binding]; other site 431943000320 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 431943000321 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 431943000322 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 431943000323 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 431943000324 MarR family; Region: MarR_2; pfam12802 431943000325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943000326 putative substrate translocation pore; other site 431943000327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943000328 putative substrate translocation pore; other site 431943000329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943000330 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 431943000331 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943000332 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 431943000333 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 431943000334 putative homodimer interface [polypeptide binding]; other site 431943000335 putative homotetramer interface [polypeptide binding]; other site 431943000336 putative metal binding site [ion binding]; other site 431943000337 putative homodimer-homodimer interface [polypeptide binding]; other site 431943000338 putative allosteric switch controlling residues; other site 431943000339 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 431943000340 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 431943000341 active site 431943000342 metal binding site [ion binding]; metal-binding site 431943000343 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 431943000344 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 431943000345 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 431943000346 GDP-binding site [chemical binding]; other site 431943000347 ACT binding site; other site 431943000348 IMP binding site; other site 431943000349 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 431943000350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 431943000351 active site 431943000352 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 431943000353 active site 431943000354 flavoprotein, HI0933 family; Region: TIGR00275 431943000355 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943000356 CoA binding domain; Region: CoA_binding_2; pfam13380 431943000357 DNA replication protein DnaC; Validated; Region: PRK06835 431943000358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943000359 Walker A motif; other site 431943000360 ATP binding site [chemical binding]; other site 431943000361 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 431943000362 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 431943000363 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 431943000364 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 431943000365 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 431943000366 FMN binding site [chemical binding]; other site 431943000367 substrate binding site [chemical binding]; other site 431943000368 putative catalytic residue [active] 431943000369 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943000370 MarR family; Region: MarR; pfam01047 431943000371 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 431943000372 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 431943000373 dimer interface [polypeptide binding]; other site 431943000374 active site 431943000375 CoA binding pocket [chemical binding]; other site 431943000376 Phosphopantetheine attachment site; Region: PP-binding; cl09936 431943000377 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 431943000378 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 431943000379 FMN binding site [chemical binding]; other site 431943000380 substrate binding site [chemical binding]; other site 431943000381 putative catalytic residue [active] 431943000382 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 431943000383 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 431943000384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 431943000385 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 431943000386 NAD(P) binding site [chemical binding]; other site 431943000387 homotetramer interface [polypeptide binding]; other site 431943000388 homodimer interface [polypeptide binding]; other site 431943000389 active site 431943000390 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 431943000391 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 431943000392 dimer interface [polypeptide binding]; other site 431943000393 active site 431943000394 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 431943000395 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 431943000396 carboxyltransferase (CT) interaction site; other site 431943000397 biotinylation site [posttranslational modification]; other site 431943000398 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 431943000399 biotin carboxylase; Validated; Region: PRK05586 431943000400 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943000401 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 431943000402 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 431943000403 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 431943000404 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 431943000405 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 431943000406 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 431943000407 Ferritin-like domain; Region: Ferritin; pfam00210 431943000408 ferroxidase diiron center [ion binding]; other site 431943000409 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 431943000410 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 431943000411 active site 431943000412 catalytic residues [active] 431943000413 Protein of unknown function, DUF606; Region: DUF606; pfam04657 431943000414 dUTPase; Region: dUTPase_2; pfam08761 431943000415 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 431943000416 active site 431943000417 homodimer interface [polypeptide binding]; other site 431943000418 metal binding site [ion binding]; metal-binding site 431943000419 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 431943000420 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 431943000421 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 431943000422 putative dimer interface [polypeptide binding]; other site 431943000423 putative anticodon binding site; other site 431943000424 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 431943000425 homodimer interface [polypeptide binding]; other site 431943000426 motif 1; other site 431943000427 motif 2; other site 431943000428 active site 431943000429 motif 3; other site 431943000430 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 431943000431 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 431943000432 DNA binding site [nucleotide binding] 431943000433 active site 431943000434 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 431943000435 Interdomain contacts; other site 431943000436 Cytokine receptor motif; other site 431943000437 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 431943000438 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 431943000439 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 431943000440 Walker A/P-loop; other site 431943000441 ATP binding site [chemical binding]; other site 431943000442 Q-loop/lid; other site 431943000443 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 431943000444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943000445 ABC transporter signature motif; other site 431943000446 Walker B; other site 431943000447 D-loop; other site 431943000448 H-loop/switch region; other site 431943000449 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 431943000450 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 431943000451 active site 431943000452 metal binding site [ion binding]; metal-binding site 431943000453 DNA binding site [nucleotide binding] 431943000454 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 431943000455 hypothetical protein; Provisional; Region: PRK05590 431943000456 SEC-C motif; Region: SEC-C; pfam02810 431943000457 YyzF-like protein; Region: YyzF; pfam14116 431943000458 Sporulation and spore germination; Region: Germane; pfam10646 431943000459 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 431943000460 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 431943000461 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 431943000462 hinge; other site 431943000463 active site 431943000464 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 431943000465 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 431943000466 glutamate racemase; Provisional; Region: PRK00865 431943000467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943000468 non-specific DNA binding site [nucleotide binding]; other site 431943000469 salt bridge; other site 431943000470 sequence-specific DNA binding site [nucleotide binding]; other site 431943000471 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 431943000472 Catalytic site [active] 431943000473 Heme NO binding; Region: HNOB; pfam07700 431943000474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943000475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943000476 dimer interface [polypeptide binding]; other site 431943000477 putative CheW interface [polypeptide binding]; other site 431943000478 Radical SAM superfamily; Region: Radical_SAM; pfam04055 431943000479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943000480 FeS/SAM binding site; other site 431943000481 Uncharacterized membrane protein [Function unknown]; Region: COG3949 431943000482 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 431943000483 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 431943000484 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 431943000485 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 431943000486 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 431943000487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943000488 motif II; other site 431943000489 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 431943000490 4Fe-4S binding domain; Region: Fer4; pfam00037 431943000491 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 431943000492 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 431943000493 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 431943000494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943000495 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 431943000496 pur operon repressor; Provisional; Region: PRK09213 431943000497 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 431943000498 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943000499 active site 431943000500 regulatory protein SpoVG; Reviewed; Region: PRK13259 431943000501 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 431943000502 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 431943000503 Substrate binding site; other site 431943000504 Mg++ binding site; other site 431943000505 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 431943000506 active site 431943000507 substrate binding site [chemical binding]; other site 431943000508 CoA binding site [chemical binding]; other site 431943000509 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 431943000510 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 431943000511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943000512 active site 431943000513 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943000514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943000515 active site 431943000516 phosphorylation site [posttranslational modification] 431943000517 intermolecular recognition site; other site 431943000518 dimerization interface [polypeptide binding]; other site 431943000519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943000520 DNA binding site [nucleotide binding] 431943000521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943000522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943000523 dimerization interface [polypeptide binding]; other site 431943000524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943000525 dimer interface [polypeptide binding]; other site 431943000526 phosphorylation site [posttranslational modification] 431943000527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943000528 ATP binding site [chemical binding]; other site 431943000529 Mg2+ binding site [ion binding]; other site 431943000530 G-X-G motif; other site 431943000531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 431943000532 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 431943000533 protein binding site [polypeptide binding]; other site 431943000534 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 431943000535 putative active site [active] 431943000536 catalytic residue [active] 431943000537 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 431943000538 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 431943000539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943000540 ATP binding site [chemical binding]; other site 431943000541 putative Mg++ binding site [ion binding]; other site 431943000542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943000543 nucleotide binding region [chemical binding]; other site 431943000544 ATP-binding site [chemical binding]; other site 431943000545 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 431943000546 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 431943000547 SurA N-terminal domain; Region: SurA_N_3; cl07813 431943000548 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 431943000549 stage V sporulation protein T; Region: spore_V_T; TIGR02851 431943000550 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 431943000551 stage V sporulation protein B; Region: spore_V_B; TIGR02900 431943000552 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 431943000553 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 431943000554 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 431943000555 putative SAM binding site [chemical binding]; other site 431943000556 putative homodimer interface [polypeptide binding]; other site 431943000557 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 431943000558 homodimer interface [polypeptide binding]; other site 431943000559 metal binding site [ion binding]; metal-binding site 431943000560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 431943000561 homodimer interface [polypeptide binding]; other site 431943000562 active site 431943000563 putative chemical substrate binding site [chemical binding]; other site 431943000564 metal binding site [ion binding]; metal-binding site 431943000565 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 431943000566 IHF dimer interface [polypeptide binding]; other site 431943000567 IHF - DNA interface [nucleotide binding]; other site 431943000568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943000569 RNA binding surface [nucleotide binding]; other site 431943000570 YabP family; Region: YabP; cl06766 431943000571 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 431943000572 Septum formation initiator; Region: DivIC; pfam04977 431943000573 hypothetical protein; Provisional; Region: PRK05807 431943000574 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 431943000575 RNA binding site [nucleotide binding]; other site 431943000576 stage II sporulation protein E; Region: spore_II_E; TIGR02865 431943000577 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 431943000578 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 431943000579 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 431943000580 Ligand Binding Site [chemical binding]; other site 431943000581 TilS substrate C-terminal domain; Region: TilS_C; smart00977 431943000582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943000583 active site 431943000584 FtsH Extracellular; Region: FtsH_ext; pfam06480 431943000585 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 431943000586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943000587 Walker A motif; other site 431943000588 ATP binding site [chemical binding]; other site 431943000589 Walker B motif; other site 431943000590 arginine finger; other site 431943000591 Peptidase family M41; Region: Peptidase_M41; pfam01434 431943000592 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 431943000593 subunit interaction site [polypeptide binding]; other site 431943000594 PHB binding site; other site 431943000595 CoenzymeA binding site [chemical binding]; other site 431943000596 pantothenate kinase; Reviewed; Region: PRK13318 431943000597 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 431943000598 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 431943000599 FMN binding site [chemical binding]; other site 431943000600 active site 431943000601 catalytic residues [active] 431943000602 substrate binding site [chemical binding]; other site 431943000603 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 431943000604 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 431943000605 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 431943000606 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 431943000607 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 431943000608 dimer interface [polypeptide binding]; other site 431943000609 putative anticodon binding site; other site 431943000610 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 431943000611 motif 1; other site 431943000612 active site 431943000613 motif 2; other site 431943000614 motif 3; other site 431943000615 glycyl-tRNA synthetase; Provisional; Region: PRK04173 431943000616 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 431943000617 motif 1; other site 431943000618 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 431943000619 active site 431943000620 motif 2; other site 431943000621 motif 3; other site 431943000622 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 431943000623 anticodon binding site; other site 431943000624 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 431943000625 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943000626 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 431943000627 elongation factor G; Reviewed; Region: PRK12740 431943000628 G1 box; other site 431943000629 putative GEF interaction site [polypeptide binding]; other site 431943000630 GTP/Mg2+ binding site [chemical binding]; other site 431943000631 Switch I region; other site 431943000632 G2 box; other site 431943000633 G3 box; other site 431943000634 Switch II region; other site 431943000635 G4 box; other site 431943000636 G5 box; other site 431943000637 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 431943000638 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 431943000639 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 431943000640 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 431943000641 catalytic core [active] 431943000642 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 431943000643 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 431943000644 UvrB/uvrC motif; Region: UVR; pfam02151 431943000645 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 431943000646 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 431943000647 ADP binding site [chemical binding]; other site 431943000648 phosphagen binding site; other site 431943000649 substrate specificity loop; other site 431943000650 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 431943000651 Clp amino terminal domain; Region: Clp_N; pfam02861 431943000652 Clp amino terminal domain; Region: Clp_N; pfam02861 431943000653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943000654 Walker A motif; other site 431943000655 ATP binding site [chemical binding]; other site 431943000656 Walker B motif; other site 431943000657 arginine finger; other site 431943000658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943000659 Walker A motif; other site 431943000660 ATP binding site [chemical binding]; other site 431943000661 Walker B motif; other site 431943000662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 431943000663 DNA repair protein RadA; Provisional; Region: PRK11823 431943000664 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 431943000665 Walker A motif/ATP binding site; other site 431943000666 ATP binding site [chemical binding]; other site 431943000667 Walker B motif; other site 431943000668 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 431943000669 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 431943000670 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 431943000671 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 431943000672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 431943000673 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 431943000674 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 431943000675 putative active site [active] 431943000676 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 431943000677 substrate binding site; other site 431943000678 dimer interface; other site 431943000679 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 431943000680 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 431943000681 active site 431943000682 HIGH motif; other site 431943000683 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 431943000684 KMSKS motif; other site 431943000685 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 431943000686 tRNA binding surface [nucleotide binding]; other site 431943000687 anticodon binding site; other site 431943000688 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 431943000689 active site 431943000690 metal binding site [ion binding]; metal-binding site 431943000691 dimerization interface [polypeptide binding]; other site 431943000692 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 431943000693 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 431943000694 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 431943000695 YacP-like NYN domain; Region: NYN_YacP; pfam05991 431943000696 RNA polymerase factor sigma-70; Validated; Region: PRK08295 431943000697 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943000698 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 431943000699 elongation factor Tu; Reviewed; Region: PRK00049 431943000700 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 431943000701 G1 box; other site 431943000702 GEF interaction site [polypeptide binding]; other site 431943000703 GTP/Mg2+ binding site [chemical binding]; other site 431943000704 Switch I region; other site 431943000705 G2 box; other site 431943000706 G3 box; other site 431943000707 Switch II region; other site 431943000708 G4 box; other site 431943000709 G5 box; other site 431943000710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 431943000711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 431943000712 Antibiotic Binding Site [chemical binding]; other site 431943000713 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 431943000714 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 431943000715 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 431943000716 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 431943000717 putative homodimer interface [polypeptide binding]; other site 431943000718 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 431943000719 heterodimer interface [polypeptide binding]; other site 431943000720 homodimer interface [polypeptide binding]; other site 431943000721 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 431943000722 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 431943000723 23S rRNA interface [nucleotide binding]; other site 431943000724 L7/L12 interface [polypeptide binding]; other site 431943000725 putative thiostrepton binding site; other site 431943000726 L25 interface [polypeptide binding]; other site 431943000727 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 431943000728 mRNA/rRNA interface [nucleotide binding]; other site 431943000729 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 431943000730 23S rRNA interface [nucleotide binding]; other site 431943000731 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 431943000732 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 431943000733 core dimer interface [polypeptide binding]; other site 431943000734 peripheral dimer interface [polypeptide binding]; other site 431943000735 L10 interface [polypeptide binding]; other site 431943000736 L11 interface [polypeptide binding]; other site 431943000737 putative EF-Tu interaction site [polypeptide binding]; other site 431943000738 putative EF-G interaction site [polypeptide binding]; other site 431943000739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 431943000740 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 431943000741 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 431943000742 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 431943000743 RPB1 interaction site [polypeptide binding]; other site 431943000744 RPB10 interaction site [polypeptide binding]; other site 431943000745 RPB11 interaction site [polypeptide binding]; other site 431943000746 RPB3 interaction site [polypeptide binding]; other site 431943000747 RPB12 interaction site [polypeptide binding]; other site 431943000748 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 431943000749 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 431943000750 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 431943000751 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 431943000752 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 431943000753 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 431943000754 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 431943000755 G-loop; other site 431943000756 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 431943000757 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 431943000758 DNA binding site [nucleotide binding] 431943000759 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 431943000760 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 431943000761 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 431943000762 S17 interaction site [polypeptide binding]; other site 431943000763 S8 interaction site; other site 431943000764 16S rRNA interaction site [nucleotide binding]; other site 431943000765 streptomycin interaction site [chemical binding]; other site 431943000766 23S rRNA interaction site [nucleotide binding]; other site 431943000767 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 431943000768 30S ribosomal protein S7; Validated; Region: PRK05302 431943000769 elongation factor G; Reviewed; Region: PRK00007 431943000770 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 431943000771 G1 box; other site 431943000772 putative GEF interaction site [polypeptide binding]; other site 431943000773 GTP/Mg2+ binding site [chemical binding]; other site 431943000774 Switch I region; other site 431943000775 G2 box; other site 431943000776 G3 box; other site 431943000777 Switch II region; other site 431943000778 G4 box; other site 431943000779 G5 box; other site 431943000780 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 431943000781 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 431943000782 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 431943000783 elongation factor Tu; Reviewed; Region: PRK00049 431943000784 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 431943000785 G1 box; other site 431943000786 GEF interaction site [polypeptide binding]; other site 431943000787 GTP/Mg2+ binding site [chemical binding]; other site 431943000788 Switch I region; other site 431943000789 G2 box; other site 431943000790 G3 box; other site 431943000791 Switch II region; other site 431943000792 G4 box; other site 431943000793 G5 box; other site 431943000794 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 431943000795 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 431943000796 Antibiotic Binding Site [chemical binding]; other site 431943000797 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 431943000798 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 431943000799 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 431943000800 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 431943000801 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 431943000802 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 431943000803 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 431943000804 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 431943000805 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 431943000806 putative translocon binding site; other site 431943000807 protein-rRNA interface [nucleotide binding]; other site 431943000808 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 431943000809 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 431943000810 G-X-X-G motif; other site 431943000811 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 431943000812 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 431943000813 23S rRNA interface [nucleotide binding]; other site 431943000814 5S rRNA interface [nucleotide binding]; other site 431943000815 putative antibiotic binding site [chemical binding]; other site 431943000816 L25 interface [polypeptide binding]; other site 431943000817 L27 interface [polypeptide binding]; other site 431943000818 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 431943000819 putative translocon interaction site; other site 431943000820 signal recognition particle (SRP54) interaction site; other site 431943000821 L23 interface [polypeptide binding]; other site 431943000822 trigger factor interaction site; other site 431943000823 23S rRNA interface [nucleotide binding]; other site 431943000824 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 431943000825 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 431943000826 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 431943000827 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 431943000828 RNA binding site [nucleotide binding]; other site 431943000829 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 431943000830 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 431943000831 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 431943000832 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 431943000833 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 431943000834 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 431943000835 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 431943000836 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 431943000837 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 431943000838 23S rRNA interface [nucleotide binding]; other site 431943000839 5S rRNA interface [nucleotide binding]; other site 431943000840 L27 interface [polypeptide binding]; other site 431943000841 L5 interface [polypeptide binding]; other site 431943000842 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 431943000843 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 431943000844 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 431943000845 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 431943000846 23S rRNA binding site [nucleotide binding]; other site 431943000847 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 431943000848 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 431943000849 SecY translocase; Region: SecY; pfam00344 431943000850 adenylate kinase; Reviewed; Region: adk; PRK00279 431943000851 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 431943000852 AMP-binding site [chemical binding]; other site 431943000853 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 431943000854 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 431943000855 active site 431943000856 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 431943000857 rRNA binding site [nucleotide binding]; other site 431943000858 predicted 30S ribosome binding site; other site 431943000859 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 431943000860 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 431943000861 30S ribosomal protein S13; Region: bact_S13; TIGR03631 431943000862 30S ribosomal protein S11; Validated; Region: PRK05309 431943000863 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 431943000864 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 431943000865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943000866 RNA binding surface [nucleotide binding]; other site 431943000867 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 431943000868 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 431943000869 alphaNTD - beta interaction site [polypeptide binding]; other site 431943000870 alphaNTD homodimer interface [polypeptide binding]; other site 431943000871 alphaNTD - beta' interaction site [polypeptide binding]; other site 431943000872 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 431943000873 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 431943000874 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 431943000875 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 431943000876 Walker A/P-loop; other site 431943000877 ATP binding site [chemical binding]; other site 431943000878 Q-loop/lid; other site 431943000879 ABC transporter signature motif; other site 431943000880 Walker B; other site 431943000881 D-loop; other site 431943000882 H-loop/switch region; other site 431943000883 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 431943000884 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 431943000885 Walker A/P-loop; other site 431943000886 ATP binding site [chemical binding]; other site 431943000887 Q-loop/lid; other site 431943000888 ABC transporter signature motif; other site 431943000889 Walker B; other site 431943000890 D-loop; other site 431943000891 H-loop/switch region; other site 431943000892 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 431943000893 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 431943000894 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 431943000895 dimerization interface 3.5A [polypeptide binding]; other site 431943000896 active site 431943000897 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 431943000898 23S rRNA interface [nucleotide binding]; other site 431943000899 L3 interface [polypeptide binding]; other site 431943000900 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 431943000901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 431943000902 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943000903 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943000904 catalytic residues [active] 431943000905 catalytic nucleophile [active] 431943000906 Recombinase; Region: Recombinase; pfam07508 431943000907 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943000908 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 431943000909 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943000910 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 431943000911 DNA binding residues [nucleotide binding] 431943000912 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 431943000913 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 431943000914 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 431943000915 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 431943000916 active site 431943000917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943000918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943000919 putative substrate translocation pore; other site 431943000920 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 431943000921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 431943000922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943000923 Protein of unknown function (DUF523); Region: DUF523; pfam04463 431943000924 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 431943000925 FMN binding site [chemical binding]; other site 431943000926 dimer interface [polypeptide binding]; other site 431943000927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943000928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943000929 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 431943000930 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 431943000931 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 431943000932 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 431943000933 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 431943000934 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 431943000935 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 431943000936 NlpC/P60 family; Region: NLPC_P60; pfam00877 431943000937 AAA-like domain; Region: AAA_10; pfam12846 431943000938 Domain of unknown function DUF87; Region: DUF87; pfam01935 431943000939 PrgI family protein; Region: PrgI; pfam12666 431943000940 SpoVG; Region: SpoVG; cl00915 431943000941 Maff2 family; Region: Maff2; pfam12750 431943000942 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 431943000943 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 431943000944 Walker A motif; other site 431943000945 ATP binding site [chemical binding]; other site 431943000946 Walker B motif; other site 431943000947 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 431943000948 Antirestriction protein (ArdA); Region: ArdA; pfam07275 431943000949 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 431943000950 ParB-like nuclease domain; Region: ParB; smart00470 431943000951 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943000952 catalytic nucleophile [active] 431943000953 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943000954 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943000955 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 431943000956 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 431943000957 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 431943000958 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 431943000959 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 431943000960 active site 431943000961 metal binding site [ion binding]; metal-binding site 431943000962 Predicted transcriptional regulators [Transcription]; Region: COG1725 431943000963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943000964 DNA-binding site [nucleotide binding]; DNA binding site 431943000965 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 431943000966 substrate binding site [chemical binding]; other site 431943000967 B12 cofactor binding site [chemical binding]; other site 431943000968 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 431943000969 fumarate hydratase; Provisional; Region: PRK06246 431943000970 Fumarase C-terminus; Region: Fumerase_C; cl00795 431943000971 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 431943000972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943000973 binding surface 431943000974 TPR motif; other site 431943000975 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943000976 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 431943000977 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 431943000978 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943000979 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 431943000980 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943000981 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 431943000982 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 431943000983 catalytic residues [active] 431943000984 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 431943000985 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 431943000986 Uncharacterized conserved protein [Function unknown]; Region: COG1624 431943000987 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 431943000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 431943000989 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 431943000990 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 431943000991 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 431943000992 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 431943000993 active site 431943000994 substrate binding site [chemical binding]; other site 431943000995 metal binding site [ion binding]; metal-binding site 431943000996 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 431943000997 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 431943000998 glutaminase active site [active] 431943000999 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 431943001000 dimer interface [polypeptide binding]; other site 431943001001 active site 431943001002 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 431943001003 dimer interface [polypeptide binding]; other site 431943001004 active site 431943001005 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943001006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 431943001008 Flavodoxin domain; Region: Flavodoxin_5; cl17428 431943001009 4Fe-4S binding domain; Region: Fer4; pfam00037 431943001010 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943001011 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943001012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943001013 non-specific DNA binding site [nucleotide binding]; other site 431943001014 salt bridge; other site 431943001015 sequence-specific DNA binding site [nucleotide binding]; other site 431943001016 Cupin domain; Region: Cupin_2; pfam07883 431943001017 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 431943001018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943001019 FeS/SAM binding site; other site 431943001020 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 431943001021 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 431943001022 dimer interface [polypeptide binding]; other site 431943001023 active site 431943001024 glycine loop; other site 431943001025 Nucleoside recognition; Region: Gate; pfam07670 431943001026 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 431943001027 pyrroline-5-carboxylate reductase; Region: PLN02688 431943001028 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 431943001029 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 431943001030 homodimer interaction site [polypeptide binding]; other site 431943001031 cofactor binding site; other site 431943001032 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 431943001033 AIR carboxylase; Region: AIRC; smart01001 431943001034 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 431943001035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 431943001036 active site 431943001037 catalytic tetrad [active] 431943001038 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943001039 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 431943001040 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 431943001041 DNA binding residues [nucleotide binding] 431943001042 putative dimer interface [polypeptide binding]; other site 431943001043 hypothetical protein; Provisional; Region: PRK04194 431943001044 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 431943001045 camphor resistance protein CrcB; Provisional; Region: PRK14232 431943001046 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 431943001047 Spore germination protein; Region: Spore_permease; cl17796 431943001048 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 431943001049 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 431943001050 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943001051 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943001052 MarR family; Region: MarR; pfam01047 431943001053 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943001054 metal binding site 2 [ion binding]; metal-binding site 431943001055 putative DNA binding helix; other site 431943001056 metal binding site 1 [ion binding]; metal-binding site 431943001057 dimer interface [polypeptide binding]; other site 431943001058 structural Zn2+ binding site [ion binding]; other site 431943001059 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 431943001060 putative FMN binding site [chemical binding]; other site 431943001061 methionine sulfoxide reductase A; Provisional; Region: PRK14054 431943001062 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943001063 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943001064 active site 431943001065 FMN binding site [chemical binding]; other site 431943001066 substrate binding site [chemical binding]; other site 431943001067 putative catalytic residue [active] 431943001068 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 431943001069 Beta-lactamase; Region: Beta-lactamase; pfam00144 431943001070 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 431943001071 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 431943001072 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 431943001073 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943001074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943001075 Zn2+ binding site [ion binding]; other site 431943001076 Mg2+ binding site [ion binding]; other site 431943001077 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943001078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943001079 non-specific DNA binding site [nucleotide binding]; other site 431943001080 salt bridge; other site 431943001081 sequence-specific DNA binding site [nucleotide binding]; other site 431943001082 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 431943001083 putative active site [active] 431943001084 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 431943001085 metal binding site [ion binding]; metal-binding site 431943001086 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 431943001087 RNA polymerase factor sigma-70; Validated; Region: PRK06811 431943001088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943001089 Predicted transcriptional regulator [Transcription]; Region: COG2378 431943001090 HTH domain; Region: HTH_11; pfam08279 431943001091 WYL domain; Region: WYL; pfam13280 431943001092 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 431943001093 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 431943001094 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 431943001095 DNA binding residues [nucleotide binding] 431943001096 dimer interface [polypeptide binding]; other site 431943001097 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 431943001098 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 431943001099 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 431943001100 DNA binding site [nucleotide binding] 431943001101 active site 431943001102 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 431943001103 active site 431943001104 catalytic residues [active] 431943001105 metal binding site [ion binding]; metal-binding site 431943001106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943001107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001108 active site 431943001109 phosphorylation site [posttranslational modification] 431943001110 intermolecular recognition site; other site 431943001111 dimerization interface [polypeptide binding]; other site 431943001112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943001113 DNA binding site [nucleotide binding] 431943001114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943001115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 431943001116 phosphorylation site [posttranslational modification] 431943001117 dimer interface [polypeptide binding]; other site 431943001118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943001119 ATP binding site [chemical binding]; other site 431943001120 Mg2+ binding site [ion binding]; other site 431943001121 G-X-G motif; other site 431943001122 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 431943001123 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 431943001124 catalytic residue [active] 431943001125 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 431943001126 catalytic residues [active] 431943001127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943001128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943001129 peroxiredoxin; Region: AhpC; TIGR03137 431943001130 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 431943001131 dimer interface [polypeptide binding]; other site 431943001132 decamer (pentamer of dimers) interface [polypeptide binding]; other site 431943001133 catalytic triad [active] 431943001134 peroxidatic and resolving cysteines [active] 431943001135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943001136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943001137 Walker A/P-loop; other site 431943001138 ATP binding site [chemical binding]; other site 431943001139 Q-loop/lid; other site 431943001140 ABC transporter signature motif; other site 431943001141 Walker B; other site 431943001142 D-loop; other site 431943001143 H-loop/switch region; other site 431943001144 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943001145 FtsX-like permease family; Region: FtsX; pfam02687 431943001146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 431943001147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943001148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943001149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943001150 Walker A/P-loop; other site 431943001151 ATP binding site [chemical binding]; other site 431943001152 Q-loop/lid; other site 431943001153 ABC transporter signature motif; other site 431943001154 Walker B; other site 431943001155 D-loop; other site 431943001156 H-loop/switch region; other site 431943001157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943001158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943001159 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 431943001160 Walker A/P-loop; other site 431943001161 ATP binding site [chemical binding]; other site 431943001162 Q-loop/lid; other site 431943001163 ABC transporter signature motif; other site 431943001164 Walker B; other site 431943001165 D-loop; other site 431943001166 H-loop/switch region; other site 431943001167 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 431943001168 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 431943001169 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 431943001170 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943001171 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943001172 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 431943001173 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 431943001174 catalytic triad [active] 431943001175 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 431943001176 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 431943001177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943001178 FeS/SAM binding site; other site 431943001179 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 431943001180 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 431943001181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943001182 FeS/SAM binding site; other site 431943001183 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 431943001184 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 431943001185 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 431943001186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943001187 Coenzyme A binding pocket [chemical binding]; other site 431943001188 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 431943001189 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 431943001190 generic binding surface I; other site 431943001191 generic binding surface II; other site 431943001192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943001193 Zn2+ binding site [ion binding]; other site 431943001194 Mg2+ binding site [ion binding]; other site 431943001195 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 431943001196 Peptidase family M50; Region: Peptidase_M50; pfam02163 431943001197 active site 431943001198 putative substrate binding region [chemical binding]; other site 431943001199 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 431943001200 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943001201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943001202 Walker A/P-loop; other site 431943001203 ATP binding site [chemical binding]; other site 431943001204 Q-loop/lid; other site 431943001205 ABC transporter signature motif; other site 431943001206 Walker B; other site 431943001207 D-loop; other site 431943001208 H-loop/switch region; other site 431943001209 Predicted transcriptional regulators [Transcription]; Region: COG1725 431943001210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943001211 DNA-binding site [nucleotide binding]; DNA binding site 431943001212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943001214 putative substrate translocation pore; other site 431943001215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943001216 MarR family; Region: MarR_2; pfam12802 431943001217 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 431943001218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001219 active site 431943001220 phosphorylation site [posttranslational modification] 431943001221 intermolecular recognition site; other site 431943001222 dimerization interface [polypeptide binding]; other site 431943001223 LytTr DNA-binding domain; Region: LytTR; smart00850 431943001224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943001225 ATP binding site [chemical binding]; other site 431943001226 Mg2+ binding site [ion binding]; other site 431943001227 G-X-G motif; other site 431943001228 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943001229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943001230 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943001231 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943001232 Walker A/P-loop; other site 431943001233 ATP binding site [chemical binding]; other site 431943001234 Q-loop/lid; other site 431943001235 ABC transporter signature motif; other site 431943001236 Walker B; other site 431943001237 D-loop; other site 431943001238 H-loop/switch region; other site 431943001239 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 431943001240 DHHW protein; Region: DHHW; pfam14286 431943001241 DHHW protein; Region: DHHW; pfam14286 431943001242 Accessory gene regulator B; Region: AgrB; pfam04647 431943001243 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943001244 Penicillinase repressor; Region: Pencillinase_R; cl17580 431943001245 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943001246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943001247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943001248 DNA binding residues [nucleotide binding] 431943001249 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 431943001250 Penicillinase repressor; Region: Pencillinase_R; pfam03965 431943001251 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943001252 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943001253 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 431943001254 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943001255 Substrate binding site [chemical binding]; other site 431943001256 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943001257 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943001258 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001259 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001260 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001261 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 431943001262 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 431943001263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943001264 Putative cyclase; Region: Cyclase; pfam04199 431943001265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943001266 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943001267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943001268 dimerization interface [polypeptide binding]; other site 431943001269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943001270 dimer interface [polypeptide binding]; other site 431943001271 putative CheW interface [polypeptide binding]; other site 431943001272 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943001273 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943001274 RecT family; Region: RecT; pfam03837 431943001275 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 431943001276 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 431943001277 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 431943001278 E-class dimer interface [polypeptide binding]; other site 431943001279 P-class dimer interface [polypeptide binding]; other site 431943001280 active site 431943001281 Cu2+ binding site [ion binding]; other site 431943001282 Zn2+ binding site [ion binding]; other site 431943001283 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 431943001284 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 431943001285 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 431943001286 Ligand Binding Site [chemical binding]; other site 431943001287 QueT transporter; Region: QueT; cl01932 431943001288 threonine dehydratase; Provisional; Region: PRK08198 431943001289 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 431943001290 tetramer interface [polypeptide binding]; other site 431943001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943001292 catalytic residue [active] 431943001293 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 431943001294 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 431943001295 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 431943001296 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 431943001297 dimer interface [polypeptide binding]; other site 431943001298 [2Fe-2S] cluster binding site [ion binding]; other site 431943001299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943001300 dimerization interface [polypeptide binding]; other site 431943001301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943001302 dimer interface [polypeptide binding]; other site 431943001303 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 431943001304 putative CheW interface [polypeptide binding]; other site 431943001305 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 431943001306 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 431943001307 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943001308 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 431943001309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943001310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 431943001311 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 431943001312 active site residue [active] 431943001313 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 431943001314 CPxP motif; other site 431943001315 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 431943001316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943001317 dimerization interface [polypeptide binding]; other site 431943001318 putative DNA binding site [nucleotide binding]; other site 431943001319 putative Zn2+ binding site [ion binding]; other site 431943001320 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 431943001321 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 431943001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 431943001323 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 431943001324 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 431943001325 ATP binding site [chemical binding]; other site 431943001326 Mg++ binding site [ion binding]; other site 431943001327 motif III; other site 431943001328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943001329 nucleotide binding region [chemical binding]; other site 431943001330 ATP-binding site [chemical binding]; other site 431943001331 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 431943001332 RNA binding site [nucleotide binding]; other site 431943001333 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 431943001334 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 431943001335 ligand binding site [chemical binding]; other site 431943001336 NAD binding site [chemical binding]; other site 431943001337 dimerization interface [polypeptide binding]; other site 431943001338 catalytic site [active] 431943001339 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 431943001340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943001341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943001342 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 431943001343 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 431943001344 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 431943001345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943001346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943001347 homodimer interface [polypeptide binding]; other site 431943001348 catalytic residue [active] 431943001349 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 431943001350 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 431943001351 Potassium binding sites [ion binding]; other site 431943001352 Cesium cation binding sites [ion binding]; other site 431943001353 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 431943001354 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 431943001355 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 431943001356 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 431943001357 homodimer interface [polypeptide binding]; other site 431943001358 NADP binding site [chemical binding]; other site 431943001359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943001360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943001361 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 431943001362 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 431943001363 UGMP family protein; Validated; Region: PRK09604 431943001364 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 431943001365 pyruvate carboxylase; Reviewed; Region: PRK12999 431943001366 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943001367 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 431943001368 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 431943001369 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 431943001370 active site 431943001371 catalytic residues [active] 431943001372 metal binding site [ion binding]; metal-binding site 431943001373 homodimer binding site [polypeptide binding]; other site 431943001374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 431943001375 carboxyltransferase (CT) interaction site; other site 431943001376 biotinylation site [posttranslational modification]; other site 431943001377 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 431943001378 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 431943001379 active site 431943001380 nucleophile elbow; other site 431943001381 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 431943001382 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 431943001383 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 431943001384 Peptidase M16C associated; Region: M16C_assoc; pfam08367 431943001385 Domain of unknown function DUF77; Region: DUF77; pfam01910 431943001386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 431943001387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001388 active site 431943001389 phosphorylation site [posttranslational modification] 431943001390 intermolecular recognition site; other site 431943001391 dimerization interface [polypeptide binding]; other site 431943001392 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 431943001393 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 431943001394 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943001395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943001396 ABC transporter; Region: ABC_tran_2; pfam12848 431943001397 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943001398 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 431943001399 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 431943001400 CoA binding domain; Region: CoA_binding; pfam02629 431943001401 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 431943001402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 431943001403 substrate binding site [chemical binding]; other site 431943001404 oxyanion hole (OAH) forming residues; other site 431943001405 trimer interface [polypeptide binding]; other site 431943001406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 431943001407 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 431943001408 active site 431943001409 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 431943001410 Ligand binding site [chemical binding]; other site 431943001411 Electron transfer flavoprotein domain; Region: ETF; pfam01012 431943001412 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 431943001413 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 431943001414 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 431943001415 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 431943001416 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 431943001417 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 431943001418 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 431943001419 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 431943001420 FAD binding pocket [chemical binding]; other site 431943001421 FAD binding motif [chemical binding]; other site 431943001422 phosphate binding motif [ion binding]; other site 431943001423 beta-alpha-beta structure motif; other site 431943001424 NAD binding pocket [chemical binding]; other site 431943001425 Iron coordination center [ion binding]; other site 431943001426 putative oxidoreductase; Provisional; Region: PRK12831 431943001427 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943001428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943001429 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 431943001430 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 431943001431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 431943001432 minor groove reading motif; other site 431943001433 helix-hairpin-helix signature motif; other site 431943001434 substrate binding pocket [chemical binding]; other site 431943001435 active site 431943001436 Uncharacterized conserved protein [Function unknown]; Region: COG0398 431943001437 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 431943001438 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 431943001439 oligomerisation interface [polypeptide binding]; other site 431943001440 mobile loop; other site 431943001441 roof hairpin; other site 431943001442 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 431943001443 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 431943001444 ring oligomerisation interface [polypeptide binding]; other site 431943001445 ATP/Mg binding site [chemical binding]; other site 431943001446 stacking interactions; other site 431943001447 hinge regions; other site 431943001448 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 431943001449 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943001450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 431943001451 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 431943001452 active site 431943001453 GMP synthase; Reviewed; Region: guaA; PRK00074 431943001454 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 431943001455 AMP/PPi binding site [chemical binding]; other site 431943001456 candidate oxyanion hole; other site 431943001457 catalytic triad [active] 431943001458 potential glutamine specificity residues [chemical binding]; other site 431943001459 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 431943001460 ATP Binding subdomain [chemical binding]; other site 431943001461 Ligand Binding sites [chemical binding]; other site 431943001462 Dimerization subdomain; other site 431943001463 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 431943001464 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943001465 active site 431943001466 Int/Topo IB signature motif; other site 431943001467 DNA binding site [nucleotide binding] 431943001468 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 431943001469 toxin interface [polypeptide binding]; other site 431943001470 Zn binding site [ion binding]; other site 431943001471 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 431943001472 large terminase protein; Provisional; Region: 17; PHA02533 431943001473 Terminase-like family; Region: Terminase_6; pfam03237 431943001474 large terminase protein; Provisional; Region: 17; PHA02533 431943001475 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 431943001476 Archaeal/vacuolar-type H+-ATPase subunit A [Energy production and conversion]; Region: NtpA; COG1155 431943001477 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 431943001478 GMP synthase C terminal domain; Region: GMP_synt_C; pfam00958 431943001479 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 431943001480 dimanganese center [ion binding]; other site 431943001481 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 431943001482 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 431943001483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943001484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943001485 non-specific DNA binding site [nucleotide binding]; other site 431943001486 salt bridge; other site 431943001487 sequence-specific DNA binding site [nucleotide binding]; other site 431943001488 HTH-like domain; Region: HTH_21; pfam13276 431943001489 Integrase core domain; Region: rve; pfam00665 431943001490 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943001491 Integrase core domain; Region: rve_3; pfam13683 431943001492 Transposase; Region: HTH_Tnp_1; cl17663 431943001493 VanZ like family; Region: VanZ; pfam04892 431943001494 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 431943001495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 431943001496 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 431943001497 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 431943001498 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 431943001499 RNA binding site [nucleotide binding]; other site 431943001500 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 431943001501 G3 box; other site 431943001502 Switch II region; other site 431943001503 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 431943001504 active site 431943001505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943001506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943001507 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 431943001508 amino acid carrier protein; Region: agcS; TIGR00835 431943001509 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 431943001510 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 431943001511 D-cysteine desulfhydrase; Validated; Region: PRK03910 431943001512 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 431943001513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943001514 catalytic residue [active] 431943001515 Protein of unknown function (DUF445); Region: DUF445; pfam04286 431943001516 Protein of unknown function (DUF445); Region: DUF445; pfam04286 431943001517 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943001518 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 431943001519 nucleotide binding site [chemical binding]; other site 431943001520 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943001521 SBD interface [polypeptide binding]; other site 431943001522 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943001523 rod shape-determining protein Mbl; Provisional; Region: PRK13928 431943001524 nucleotide binding site [chemical binding]; other site 431943001525 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943001526 SBD interface [polypeptide binding]; other site 431943001527 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 431943001528 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943001529 nucleotide binding site [chemical binding]; other site 431943001530 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943001531 SBD interface [polypeptide binding]; other site 431943001532 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 431943001533 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943001534 nucleotide binding site [chemical binding]; other site 431943001535 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943001536 SBD interface [polypeptide binding]; other site 431943001537 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 431943001538 metal ion-dependent adhesion site (MIDAS); other site 431943001539 chromosome segregation protein; Provisional; Region: PRK03918 431943001540 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 431943001541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 431943001542 ligand binding site [chemical binding]; other site 431943001543 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001544 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001545 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943001546 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 431943001547 active site 431943001548 catalytic triad [active] 431943001549 oxyanion hole [active] 431943001550 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 431943001551 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943001552 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943001553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943001554 Walker A/P-loop; other site 431943001555 ATP binding site [chemical binding]; other site 431943001556 Q-loop/lid; other site 431943001557 ABC transporter signature motif; other site 431943001558 Walker B; other site 431943001559 D-loop; other site 431943001560 H-loop/switch region; other site 431943001561 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 431943001562 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 431943001563 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 431943001564 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943001565 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943001566 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943001567 LytTr DNA-binding domain; Region: LytTR; smart00850 431943001568 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 431943001569 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943001570 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943001571 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 431943001572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 431943001573 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 431943001574 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 431943001575 active site clefts [active] 431943001576 zinc binding site [ion binding]; other site 431943001577 dimer interface [polypeptide binding]; other site 431943001578 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 431943001579 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 431943001580 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 431943001581 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 431943001582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 431943001583 transglutaminase; Provisional; Region: tgl; PRK03187 431943001584 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 431943001585 Zn binding site [ion binding]; other site 431943001586 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 431943001587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943001588 putative active site [active] 431943001589 heme pocket [chemical binding]; other site 431943001590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943001591 Walker A motif; other site 431943001592 ATP binding site [chemical binding]; other site 431943001593 Walker B motif; other site 431943001594 arginine finger; other site 431943001595 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 431943001596 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943001597 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 431943001598 putative active site [active] 431943001599 metal binding site [ion binding]; metal-binding site 431943001600 benzoate transport; Region: 2A0115; TIGR00895 431943001601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001602 putative substrate translocation pore; other site 431943001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001604 isocitrate dehydrogenase; Validated; Region: PRK08299 431943001605 Putative cyclase; Region: Cyclase; cl00814 431943001606 Cupin domain; Region: Cupin_2; cl17218 431943001607 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 431943001608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943001609 Coenzyme A binding pocket [chemical binding]; other site 431943001610 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 431943001611 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943001612 DNA binding residues [nucleotide binding] 431943001613 dimer interface [polypeptide binding]; other site 431943001614 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 431943001615 Acyltransferase family; Region: Acyl_transf_3; pfam01757 431943001616 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 431943001617 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 431943001618 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 431943001619 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943001620 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943001621 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 431943001622 MutS domain III; Region: MutS_III; pfam05192 431943001623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943001624 Walker A/P-loop; other site 431943001625 ATP binding site [chemical binding]; other site 431943001626 Q-loop/lid; other site 431943001627 ABC transporter signature motif; other site 431943001628 Walker B; other site 431943001629 D-loop; other site 431943001630 H-loop/switch region; other site 431943001631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 431943001632 Transposase, Mutator family; Region: Transposase_mut; pfam00872 431943001633 Transposase, Mutator family; Region: Transposase_mut; pfam00872 431943001634 MULE transposase domain; Region: MULE; pfam10551 431943001635 DNA topoisomerase III; Provisional; Region: PRK07726 431943001636 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 431943001637 active site 431943001638 putative interdomain interaction site [polypeptide binding]; other site 431943001639 putative metal-binding site [ion binding]; other site 431943001640 putative nucleotide binding site [chemical binding]; other site 431943001641 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 431943001642 domain I; other site 431943001643 DNA binding groove [nucleotide binding] 431943001644 phosphate binding site [ion binding]; other site 431943001645 domain II; other site 431943001646 domain III; other site 431943001647 nucleotide binding site [chemical binding]; other site 431943001648 catalytic site [active] 431943001649 domain IV; other site 431943001650 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 431943001651 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 431943001652 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943001653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001654 active site 431943001655 phosphorylation site [posttranslational modification] 431943001656 intermolecular recognition site; other site 431943001657 dimerization interface [polypeptide binding]; other site 431943001658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943001659 DNA binding site [nucleotide binding] 431943001660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943001661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943001662 dimerization interface [polypeptide binding]; other site 431943001663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943001664 dimer interface [polypeptide binding]; other site 431943001665 phosphorylation site [posttranslational modification] 431943001666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943001667 ATP binding site [chemical binding]; other site 431943001668 Mg2+ binding site [ion binding]; other site 431943001669 G-X-G motif; other site 431943001670 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 431943001671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943001672 NAD(P) binding site [chemical binding]; other site 431943001673 active site 431943001674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 431943001675 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 431943001676 NAD(P) binding site [chemical binding]; other site 431943001677 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 431943001678 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 431943001679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943001680 motif II; other site 431943001681 Predicted transcriptional regulators [Transcription]; Region: COG1733 431943001682 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943001683 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 431943001684 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 431943001685 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 431943001686 nucleotide binding site [chemical binding]; other site 431943001687 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 431943001688 nucleotide binding site [chemical binding]; other site 431943001689 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 431943001690 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943001691 DNA binding residues [nucleotide binding] 431943001692 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 431943001693 CoenzymeA binding site [chemical binding]; other site 431943001694 subunit interaction site [polypeptide binding]; other site 431943001695 PHB binding site; other site 431943001696 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 431943001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001698 active site 431943001699 phosphorylation site [posttranslational modification] 431943001700 intermolecular recognition site; other site 431943001701 dimerization interface [polypeptide binding]; other site 431943001702 CheB methylesterase; Region: CheB_methylest; pfam01339 431943001703 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 431943001704 methyl-accepting protein IV; Provisional; Region: PRK09793 431943001705 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 431943001706 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 431943001707 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943001708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943001709 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943001710 Transcriptional regulator PadR-like family; Region: PadR; cl17335 431943001711 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 431943001712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 431943001713 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 431943001714 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 431943001715 putative active site [active] 431943001716 putative NTP binding site [chemical binding]; other site 431943001717 putative nucleic acid binding site [nucleotide binding]; other site 431943001718 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 431943001719 active site 431943001720 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 431943001721 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 431943001722 G-X-G motif; other site 431943001723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 431943001724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943001725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943001726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943001727 dimerization interface [polypeptide binding]; other site 431943001728 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 431943001729 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943001730 active site 431943001731 FMN binding site [chemical binding]; other site 431943001732 substrate binding site [chemical binding]; other site 431943001733 putative catalytic residue [active] 431943001734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943001735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943001736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943001739 putative substrate translocation pore; other site 431943001740 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 431943001741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 431943001742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 431943001743 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 431943001744 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 431943001745 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 431943001746 active site 431943001747 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943001748 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 431943001749 NodB motif; other site 431943001750 active site 431943001751 catalytic site [active] 431943001752 Zn binding site [ion binding]; other site 431943001753 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 431943001754 prolyl-tRNA synthetase; Provisional; Region: PRK08661 431943001755 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 431943001756 dimer interface [polypeptide binding]; other site 431943001757 motif 1; other site 431943001758 active site 431943001759 motif 2; other site 431943001760 motif 3; other site 431943001761 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 431943001762 anticodon binding site; other site 431943001763 zinc-binding site [ion binding]; other site 431943001764 FtsH Extracellular; Region: FtsH_ext; pfam06480 431943001765 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 431943001766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943001767 Walker A motif; other site 431943001768 ATP binding site [chemical binding]; other site 431943001769 Walker B motif; other site 431943001770 arginine finger; other site 431943001771 Peptidase family M41; Region: Peptidase_M41; pfam01434 431943001772 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 431943001773 Part of AAA domain; Region: AAA_19; pfam13245 431943001774 Family description; Region: UvrD_C_2; pfam13538 431943001775 biotin synthase; Provisional; Region: PRK07094 431943001776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943001777 FeS/SAM binding site; other site 431943001778 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 431943001779 aspartate kinase; Reviewed; Region: PRK06635 431943001780 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 431943001781 putative nucleotide binding site [chemical binding]; other site 431943001782 putative catalytic residues [active] 431943001783 putative Mg ion binding site [ion binding]; other site 431943001784 putative aspartate binding site [chemical binding]; other site 431943001785 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 431943001786 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 431943001787 putative allosteric regulatory residue; other site 431943001788 diaminopimelate decarboxylase; Region: lysA; TIGR01048 431943001789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 431943001790 active site 431943001791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 431943001792 substrate binding site [chemical binding]; other site 431943001793 catalytic residues [active] 431943001794 dimer interface [polypeptide binding]; other site 431943001795 Putative glucoamylase; Region: Glycoamylase; pfam10091 431943001796 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 431943001797 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 431943001798 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 431943001799 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 431943001800 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 431943001801 active site 431943001802 HIGH motif; other site 431943001803 dimer interface [polypeptide binding]; other site 431943001804 KMSKS motif; other site 431943001805 Catalytic domain of Protein Kinases; Region: PKc; cd00180 431943001806 active site 431943001807 ATP binding site [chemical binding]; other site 431943001808 substrate binding site [chemical binding]; other site 431943001809 activation loop (A-loop); other site 431943001810 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 431943001811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943001812 FeS/SAM binding site; other site 431943001813 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 431943001814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 431943001815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 431943001816 YheO-like PAS domain; Region: PAS_6; pfam08348 431943001817 HTH domain; Region: HTH_22; pfam13309 431943001818 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 431943001819 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 431943001820 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943001821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943001822 metal binding site [ion binding]; metal-binding site 431943001823 active site 431943001824 I-site; other site 431943001825 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 431943001826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943001827 Walker A/P-loop; other site 431943001828 ATP binding site [chemical binding]; other site 431943001829 Q-loop/lid; other site 431943001830 ABC transporter signature motif; other site 431943001831 Walker B; other site 431943001832 D-loop; other site 431943001833 H-loop/switch region; other site 431943001834 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 431943001835 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 431943001836 TM-ABC transporter signature motif; other site 431943001837 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 431943001838 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 431943001839 zinc binding site [ion binding]; other site 431943001840 putative ligand binding site [chemical binding]; other site 431943001841 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 431943001842 hexamer interface [polypeptide binding]; other site 431943001843 RNA binding site [nucleotide binding]; other site 431943001844 Histidine-zinc binding site [chemical binding]; other site 431943001845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943001846 S-adenosylmethionine binding site [chemical binding]; other site 431943001847 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 431943001848 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 431943001849 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 431943001850 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 431943001851 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 431943001852 switch II; other site 431943001853 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 431943001854 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 431943001855 P loop nucleotide binding; other site 431943001856 switch II; other site 431943001857 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 431943001858 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 431943001859 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943001860 metal binding site 2 [ion binding]; metal-binding site 431943001861 putative DNA binding helix; other site 431943001862 metal binding site 1 [ion binding]; metal-binding site 431943001863 dimer interface [polypeptide binding]; other site 431943001864 structural Zn2+ binding site [ion binding]; other site 431943001865 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 431943001866 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943001867 DNA binding residues [nucleotide binding] 431943001868 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 431943001869 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 431943001870 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 431943001871 trimerization site [polypeptide binding]; other site 431943001872 active site 431943001873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 431943001874 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 431943001875 FAD binding site [chemical binding]; other site 431943001876 homotetramer interface [polypeptide binding]; other site 431943001877 substrate binding pocket [chemical binding]; other site 431943001878 catalytic base [active] 431943001879 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 431943001880 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 431943001881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943001882 DNA binding residues [nucleotide binding] 431943001883 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 431943001884 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 431943001885 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 431943001886 oligomerization interface [polypeptide binding]; other site 431943001887 active site 431943001888 metal binding site [ion binding]; metal-binding site 431943001889 Pantoate-beta-alanine ligase; Region: PanC; cd00560 431943001890 pantoate--beta-alanine ligase; Region: panC; TIGR00018 431943001891 active site 431943001892 ATP-binding site [chemical binding]; other site 431943001893 pantoate-binding site; other site 431943001894 HXXH motif; other site 431943001895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 431943001896 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 431943001897 active site 431943001898 motif I; other site 431943001899 motif II; other site 431943001900 SpoVR like protein; Region: SpoVR; pfam04293 431943001901 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 431943001902 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 431943001903 metal ion-dependent adhesion site (MIDAS); other site 431943001904 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 431943001905 AAA ATPase domain; Region: AAA_16; pfam13191 431943001906 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 431943001907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 431943001908 MarR family; Region: MarR_2; pfam12802 431943001909 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 431943001910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001911 putative substrate translocation pore; other site 431943001912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943001913 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 431943001914 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 431943001915 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943001916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 431943001917 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943001918 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 431943001919 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 431943001920 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 431943001921 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 431943001922 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 431943001923 catalytic site [active] 431943001924 subunit interface [polypeptide binding]; other site 431943001925 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 431943001926 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943001927 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 431943001928 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 431943001929 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943001930 ATP-grasp domain; Region: ATP-grasp_4; cl17255 431943001931 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 431943001932 IMP binding site; other site 431943001933 dimer interface [polypeptide binding]; other site 431943001934 interdomain contacts; other site 431943001935 partial ornithine binding site; other site 431943001936 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 431943001937 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 431943001938 metal binding site [ion binding]; metal-binding site 431943001939 dimer interface [polypeptide binding]; other site 431943001940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943001941 dimer interface [polypeptide binding]; other site 431943001942 phosphorylation site [posttranslational modification] 431943001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943001944 ATP binding site [chemical binding]; other site 431943001945 Mg2+ binding site [ion binding]; other site 431943001946 G-X-G motif; other site 431943001947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943001949 active site 431943001950 phosphorylation site [posttranslational modification] 431943001951 intermolecular recognition site; other site 431943001952 dimerization interface [polypeptide binding]; other site 431943001953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943001954 DNA binding site [nucleotide binding] 431943001955 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 431943001956 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 431943001957 Ligand binding site; other site 431943001958 Putative Catalytic site; other site 431943001959 DXD motif; other site 431943001960 Predicted membrane protein [Function unknown]; Region: COG2246 431943001961 GtrA-like protein; Region: GtrA; pfam04138 431943001962 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 431943001963 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 431943001964 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 431943001965 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 431943001966 tRNA; other site 431943001967 putative tRNA binding site [nucleotide binding]; other site 431943001968 putative NADP binding site [chemical binding]; other site 431943001969 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 431943001970 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 431943001971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943001972 inhibitor-cofactor binding pocket; inhibition site 431943001973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943001974 catalytic residue [active] 431943001975 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 431943001976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943001977 putative DNA binding site [nucleotide binding]; other site 431943001978 putative Zn2+ binding site [ion binding]; other site 431943001979 AsnC family; Region: AsnC_trans_reg; pfam01037 431943001980 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 431943001981 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 431943001982 hexamer interface [polypeptide binding]; other site 431943001983 ligand binding site [chemical binding]; other site 431943001984 putative active site [active] 431943001985 NAD(P) binding site [chemical binding]; other site 431943001986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 431943001987 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 431943001988 Predicted integral membrane protein [Function unknown]; Region: COG5542 431943001989 EDD domain protein, DegV family; Region: DegV; TIGR00762 431943001990 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 431943001991 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 431943001992 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 431943001993 Walker A/P-loop; other site 431943001994 ATP binding site [chemical binding]; other site 431943001995 Q-loop/lid; other site 431943001996 ABC transporter signature motif; other site 431943001997 Walker B; other site 431943001998 D-loop; other site 431943001999 H-loop/switch region; other site 431943002000 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 431943002001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943002002 dimer interface [polypeptide binding]; other site 431943002003 conserved gate region; other site 431943002004 ABC-ATPase subunit interface; other site 431943002005 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943002006 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943002007 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 431943002008 Protein of unknown function DUF116; Region: DUF116; pfam01976 431943002009 DNA polymerase I; Provisional; Region: PRK05755 431943002010 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 431943002011 active site 431943002012 metal binding site 1 [ion binding]; metal-binding site 431943002013 putative 5' ssDNA interaction site; other site 431943002014 metal binding site 3; metal-binding site 431943002015 metal binding site 2 [ion binding]; metal-binding site 431943002016 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 431943002017 putative DNA binding site [nucleotide binding]; other site 431943002018 putative metal binding site [ion binding]; other site 431943002019 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 431943002020 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 431943002021 active site 431943002022 DNA binding site [nucleotide binding] 431943002023 catalytic site [active] 431943002024 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 431943002025 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 431943002026 CoA-binding site [chemical binding]; other site 431943002027 ATP-binding [chemical binding]; other site 431943002028 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 431943002029 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 431943002030 N-acetyl-D-glucosamine binding site [chemical binding]; other site 431943002031 catalytic residue [active] 431943002032 short chain dehydrogenase; Provisional; Region: PRK06701 431943002033 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 431943002034 NAD binding site [chemical binding]; other site 431943002035 metal binding site [ion binding]; metal-binding site 431943002036 active site 431943002037 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 431943002038 dimanganese center [ion binding]; other site 431943002039 CotJB protein; Region: CotJB; pfam12652 431943002040 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 431943002041 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 431943002042 dinuclear metal binding motif [ion binding]; other site 431943002043 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 431943002044 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 431943002045 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 431943002046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943002047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943002048 dimerization interface [polypeptide binding]; other site 431943002049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943002050 dimer interface [polypeptide binding]; other site 431943002051 phosphorylation site [posttranslational modification] 431943002052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943002053 ATP binding site [chemical binding]; other site 431943002054 Mg2+ binding site [ion binding]; other site 431943002055 G-X-G motif; other site 431943002056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943002057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943002058 dimerization interface [polypeptide binding]; other site 431943002059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943002060 dimer interface [polypeptide binding]; other site 431943002061 phosphorylation site [posttranslational modification] 431943002062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943002063 ATP binding site [chemical binding]; other site 431943002064 Mg2+ binding site [ion binding]; other site 431943002065 G-X-G motif; other site 431943002066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943002067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943002068 active site 431943002069 phosphorylation site [posttranslational modification] 431943002070 intermolecular recognition site; other site 431943002071 dimerization interface [polypeptide binding]; other site 431943002072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943002073 DNA binding site [nucleotide binding] 431943002074 EamA-like transporter family; Region: EamA; pfam00892 431943002075 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 431943002076 EamA-like transporter family; Region: EamA; pfam00892 431943002077 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 431943002078 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 431943002079 metal binding site [ion binding]; metal-binding site 431943002080 dimer interface [polypeptide binding]; other site 431943002081 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 431943002082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 431943002083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 431943002084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 431943002085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943002086 catalytic residue [active] 431943002087 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 431943002088 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 431943002089 active pocket/dimerization site; other site 431943002090 active site 431943002091 phosphorylation site [posttranslational modification] 431943002092 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 431943002093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943002094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943002095 homodimer interface [polypeptide binding]; other site 431943002096 catalytic residue [active] 431943002097 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 431943002098 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 431943002099 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 431943002100 putative L-serine binding site [chemical binding]; other site 431943002101 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 431943002102 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 431943002103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 431943002104 DNA-binding site [nucleotide binding]; DNA binding site 431943002105 RNA-binding motif; other site 431943002106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943002107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943002108 putative substrate translocation pore; other site 431943002109 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 431943002110 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 431943002111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943002112 catalytic residue [active] 431943002113 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 431943002114 GAF domain; Region: GAF_3; pfam13492 431943002115 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943002116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943002117 metal binding site [ion binding]; metal-binding site 431943002118 active site 431943002119 I-site; other site 431943002120 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 431943002121 Family description; Region: UvrD_C_2; pfam13538 431943002122 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 431943002123 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 431943002124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943002125 dimer interface [polypeptide binding]; other site 431943002126 conserved gate region; other site 431943002127 putative PBP binding loops; other site 431943002128 ABC-ATPase subunit interface; other site 431943002129 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 431943002130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943002131 substrate binding pocket [chemical binding]; other site 431943002132 membrane-bound complex binding site; other site 431943002133 hinge residues; other site 431943002134 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 431943002135 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 431943002136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 431943002137 Peptidase M16C associated; Region: M16C_assoc; pfam08367 431943002138 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 431943002139 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 431943002140 catalytic loop [active] 431943002141 iron binding site [ion binding]; other site 431943002142 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 431943002143 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 431943002144 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 431943002145 active site 431943002146 catalytic residues [active] 431943002147 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 431943002148 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 431943002149 dimer interface [polypeptide binding]; other site 431943002150 active site 431943002151 Schiff base residues; other site 431943002152 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 431943002153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943002154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943002155 homodimer interface [polypeptide binding]; other site 431943002156 catalytic residue [active] 431943002157 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 431943002158 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 431943002159 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 431943002160 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 431943002161 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 431943002162 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 431943002163 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 431943002164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 431943002165 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 431943002166 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 431943002167 domain interfaces; other site 431943002168 active site 431943002169 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 431943002170 diphthine synthase; Region: dph5; TIGR00522 431943002171 active site 431943002172 SAM binding site [chemical binding]; other site 431943002173 homodimer interface [polypeptide binding]; other site 431943002174 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 431943002175 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 431943002176 active site 431943002177 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 431943002178 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 431943002179 active site 431943002180 C-terminal domain interface [polypeptide binding]; other site 431943002181 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 431943002182 active site 431943002183 N-terminal domain interface [polypeptide binding]; other site 431943002184 cobyric acid synthase; Provisional; Region: PRK00784 431943002185 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 431943002186 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 431943002187 catalytic triad [active] 431943002188 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943002189 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 431943002190 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 431943002191 catalytic triad [active] 431943002192 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 431943002193 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 431943002194 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 431943002195 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 431943002196 active site 431943002197 putative homodimer interface [polypeptide binding]; other site 431943002198 SAM binding site [chemical binding]; other site 431943002199 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 431943002200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943002201 S-adenosylmethionine binding site [chemical binding]; other site 431943002202 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 431943002203 active site 431943002204 SAM binding site [chemical binding]; other site 431943002205 homodimer interface [polypeptide binding]; other site 431943002206 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 431943002207 active site 431943002208 SAM binding site [chemical binding]; other site 431943002209 homodimer interface [polypeptide binding]; other site 431943002210 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 431943002211 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 431943002212 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 431943002213 active site 431943002214 SAM binding site [chemical binding]; other site 431943002215 homodimer interface [polypeptide binding]; other site 431943002216 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 431943002217 homotrimer interface [polypeptide binding]; other site 431943002218 Walker A motif; other site 431943002219 GTP binding site [chemical binding]; other site 431943002220 Walker B motif; other site 431943002221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 431943002222 catalytic core [active] 431943002223 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 431943002224 Predicted transcriptional regulators [Transcription]; Region: COG1733 431943002225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943002226 putative DNA binding site [nucleotide binding]; other site 431943002227 putative Zn2+ binding site [ion binding]; other site 431943002228 Cache domain; Region: Cache_1; pfam02743 431943002229 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943002230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943002231 dimer interface [polypeptide binding]; other site 431943002232 putative CheW interface [polypeptide binding]; other site 431943002233 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 431943002234 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943002235 putative active site [active] 431943002236 metal binding site [ion binding]; metal-binding site 431943002237 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 431943002238 putative metal binding site [ion binding]; other site 431943002239 putative dimer interface [polypeptide binding]; other site 431943002240 amino acid transporter; Region: 2A0306; TIGR00909 431943002241 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 431943002242 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 431943002243 MgtC family; Region: MgtC; pfam02308 431943002244 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943002245 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 431943002246 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943002247 phosphate binding site [ion binding]; other site 431943002248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943002249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943002250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943002251 CAAX protease self-immunity; Region: Abi; pfam02517 431943002252 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 431943002253 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943002254 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943002255 active site 431943002256 FMN binding site [chemical binding]; other site 431943002257 substrate binding site [chemical binding]; other site 431943002258 putative catalytic residue [active] 431943002259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943002260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943002261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943002262 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 431943002263 Quinolinate synthetase A protein; Region: NadA; pfam02445 431943002264 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 431943002265 L-aspartate oxidase; Provisional; Region: PRK06175 431943002266 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 431943002267 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 431943002268 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 431943002269 dimerization interface [polypeptide binding]; other site 431943002270 active site 431943002271 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943002272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002273 Zn2+ binding site [ion binding]; other site 431943002274 Mg2+ binding site [ion binding]; other site 431943002275 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 431943002276 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 431943002277 G1 box; other site 431943002278 putative GEF interaction site [polypeptide binding]; other site 431943002279 GTP/Mg2+ binding site [chemical binding]; other site 431943002280 Switch I region; other site 431943002281 G2 box; other site 431943002282 G3 box; other site 431943002283 Switch II region; other site 431943002284 G4 box; other site 431943002285 G5 box; other site 431943002286 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 431943002287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 431943002288 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 431943002289 active site 431943002290 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 431943002291 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 431943002292 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 431943002293 Divergent AAA domain; Region: AAA_4; pfam04326 431943002294 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 431943002295 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 431943002296 active site 431943002297 HIGH motif; other site 431943002298 dimer interface [polypeptide binding]; other site 431943002299 KMSKS motif; other site 431943002300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943002301 RNA binding surface [nucleotide binding]; other site 431943002302 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 431943002303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943002304 Coenzyme A binding pocket [chemical binding]; other site 431943002305 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 431943002306 Glycoprotease family; Region: Peptidase_M22; pfam00814 431943002307 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 431943002308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002309 Zn2+ binding site [ion binding]; other site 431943002310 Mg2+ binding site [ion binding]; other site 431943002311 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943002312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002313 Zn2+ binding site [ion binding]; other site 431943002314 Mg2+ binding site [ion binding]; other site 431943002315 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 431943002316 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 431943002317 intersubunit interface [polypeptide binding]; other site 431943002318 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 431943002319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 431943002320 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943002321 phosphate binding site [ion binding]; other site 431943002322 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943002323 EamA-like transporter family; Region: EamA; pfam00892 431943002324 EamA-like transporter family; Region: EamA; pfam00892 431943002325 Amidinotransferase; Region: Amidinotransf; cl12043 431943002326 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 431943002327 Amidinotransferase; Region: Amidinotransf; pfam02274 431943002328 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 431943002329 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 431943002330 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 431943002331 L-aspartate oxidase; Provisional; Region: PRK06175 431943002332 L-aspartate oxidase; Provisional; Region: PRK06175 431943002333 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 431943002334 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 431943002335 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943002336 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 431943002337 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 431943002338 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 431943002339 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 431943002340 Walker A/P-loop; other site 431943002341 ATP binding site [chemical binding]; other site 431943002342 Q-loop/lid; other site 431943002343 ABC transporter signature motif; other site 431943002344 Walker B; other site 431943002345 D-loop; other site 431943002346 H-loop/switch region; other site 431943002347 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 431943002348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943002349 dimer interface [polypeptide binding]; other site 431943002350 conserved gate region; other site 431943002351 putative PBP binding loops; other site 431943002352 ABC-ATPase subunit interface; other site 431943002353 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 431943002354 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 431943002355 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 431943002356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943002357 NAD(P) binding site [chemical binding]; other site 431943002358 active site 431943002359 Response regulator receiver domain; Region: Response_reg; pfam00072 431943002360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943002361 active site 431943002362 phosphorylation site [posttranslational modification] 431943002363 intermolecular recognition site; other site 431943002364 dimerization interface [polypeptide binding]; other site 431943002365 CHAP domain; Region: CHAP; cl17642 431943002366 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943002367 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943002368 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943002369 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 431943002370 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 431943002371 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 431943002372 prephenate dehydrogenase; Validated; Region: PRK08507 431943002373 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 431943002374 active site 431943002375 dimer interface [polypeptide binding]; other site 431943002376 metal binding site [ion binding]; metal-binding site 431943002377 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 431943002378 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 431943002379 hinge; other site 431943002380 active site 431943002381 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 431943002382 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 431943002383 Tetramer interface [polypeptide binding]; other site 431943002384 active site 431943002385 FMN-binding site [chemical binding]; other site 431943002386 Chorismate mutase type II; Region: CM_2; smart00830 431943002387 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 431943002388 Prephenate dehydratase; Region: PDT; pfam00800 431943002389 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 431943002390 putative L-Phe binding site [chemical binding]; other site 431943002391 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 431943002392 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 431943002393 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 431943002394 shikimate binding site; other site 431943002395 NAD(P) binding site [chemical binding]; other site 431943002396 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 431943002397 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 431943002398 ADP binding site [chemical binding]; other site 431943002399 magnesium binding site [ion binding]; other site 431943002400 putative shikimate binding site; other site 431943002401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 431943002402 Uncharacterized conserved protein [Function unknown]; Region: COG3391 431943002403 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 431943002404 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 431943002405 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 431943002406 putative homodimer interface [polypeptide binding]; other site 431943002407 putative homotetramer interface [polypeptide binding]; other site 431943002408 putative allosteric switch controlling residues; other site 431943002409 putative metal binding site [ion binding]; other site 431943002410 putative homodimer-homodimer interface [polypeptide binding]; other site 431943002411 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943002412 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 431943002413 metal-binding site [ion binding] 431943002414 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943002415 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943002416 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 431943002417 metal-binding site [ion binding] 431943002418 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 431943002419 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 431943002420 active site 431943002421 substrate binding site [chemical binding]; other site 431943002422 metal binding site [ion binding]; metal-binding site 431943002423 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 431943002424 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 431943002425 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 431943002426 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 431943002427 putative active site [active] 431943002428 catalytic site [active] 431943002429 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 431943002430 putative active site [active] 431943002431 catalytic site [active] 431943002432 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 431943002433 active site 431943002434 FOG: CBS domain [General function prediction only]; Region: COG0517 431943002435 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 431943002436 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943002437 Predicted membrane protein [Function unknown]; Region: COG4684 431943002438 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 431943002439 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 431943002440 putative active site pocket [active] 431943002441 cleavage site 431943002442 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 431943002443 RNA binding site [nucleotide binding]; other site 431943002444 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 431943002445 RNA binding site [nucleotide binding]; other site 431943002446 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 431943002447 RNA binding site [nucleotide binding]; other site 431943002448 Sensory domain found in PocR; Region: PocR; pfam10114 431943002449 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943002450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943002451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943002452 metal binding site [ion binding]; metal-binding site 431943002453 active site 431943002454 I-site; other site 431943002455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943002456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943002457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943002458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943002459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943002460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943002461 Walker A/P-loop; other site 431943002462 ATP binding site [chemical binding]; other site 431943002463 Q-loop/lid; other site 431943002464 ABC transporter signature motif; other site 431943002465 Walker B; other site 431943002466 D-loop; other site 431943002467 H-loop/switch region; other site 431943002468 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943002469 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943002470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943002471 Walker A/P-loop; other site 431943002472 ATP binding site [chemical binding]; other site 431943002473 Q-loop/lid; other site 431943002474 ABC transporter signature motif; other site 431943002475 Walker B; other site 431943002476 D-loop; other site 431943002477 H-loop/switch region; other site 431943002478 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943002479 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 431943002480 NodB motif; other site 431943002481 active site 431943002482 catalytic site [active] 431943002483 Zn binding site [ion binding]; other site 431943002484 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 431943002485 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 431943002486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943002487 catalytic residue [active] 431943002488 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 431943002489 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 431943002490 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 431943002491 Ligand Binding Site [chemical binding]; other site 431943002492 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 431943002493 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 431943002494 Double zinc ribbon; Region: DZR; pfam12773 431943002495 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 431943002496 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 431943002497 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 431943002498 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 431943002499 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 431943002500 Walker A/P-loop; other site 431943002501 ATP binding site [chemical binding]; other site 431943002502 Q-loop/lid; other site 431943002503 ABC transporter signature motif; other site 431943002504 Walker B; other site 431943002505 D-loop; other site 431943002506 H-loop/switch region; other site 431943002507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943002508 dimer interface [polypeptide binding]; other site 431943002509 conserved gate region; other site 431943002510 ABC-ATPase subunit interface; other site 431943002511 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 431943002512 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 431943002513 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943002514 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943002515 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943002516 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943002517 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 431943002518 FeS assembly ATPase SufC; Region: sufC; TIGR01978 431943002519 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 431943002520 Walker A/P-loop; other site 431943002521 ATP binding site [chemical binding]; other site 431943002522 Q-loop/lid; other site 431943002523 ABC transporter signature motif; other site 431943002524 Walker B; other site 431943002525 D-loop; other site 431943002526 H-loop/switch region; other site 431943002527 FeS assembly protein SufB; Region: sufB; TIGR01980 431943002528 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 431943002529 FeS assembly protein SufD; Region: sufD; TIGR01981 431943002530 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 431943002531 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 431943002532 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 431943002533 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943002534 catalytic residue [active] 431943002535 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 431943002536 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 431943002537 trimerization site [polypeptide binding]; other site 431943002538 active site 431943002539 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 431943002540 adenosine deaminase; Provisional; Region: PRK09358 431943002541 active site 431943002542 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943002543 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943002544 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 431943002545 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 431943002546 dimer interface [polypeptide binding]; other site 431943002547 [2Fe-2S] cluster binding site [ion binding]; other site 431943002548 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 431943002549 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 431943002550 4Fe-4S binding domain; Region: Fer4; pfam00037 431943002551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 431943002552 catalytic loop [active] 431943002553 iron binding site [ion binding]; other site 431943002554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943002555 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 431943002556 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 431943002557 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 431943002558 4Fe-4S binding domain; Region: Fer4; pfam00037 431943002559 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 431943002560 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 431943002561 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 431943002562 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 431943002563 Hexamer interface [polypeptide binding]; other site 431943002564 Putative hexagonal pore residue; other site 431943002565 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 431943002566 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 431943002567 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 431943002568 alpha-beta subunit interface [polypeptide binding]; other site 431943002569 alpha-gamma subunit interface [polypeptide binding]; other site 431943002570 active site 431943002571 substrate and K+ binding site; other site 431943002572 K+ binding site [ion binding]; other site 431943002573 cobalamin binding site [chemical binding]; other site 431943002574 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 431943002575 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 431943002576 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 431943002577 Hexamer interface [polypeptide binding]; other site 431943002578 Hexagonal pore residue; other site 431943002579 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 431943002580 Propanediol utilisation protein PduL; Region: PduL; pfam06130 431943002581 Propanediol utilisation protein PduL; Region: PduL; pfam06130 431943002582 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 431943002583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 431943002584 nucleotide binding site [chemical binding]; other site 431943002585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 431943002586 Flavoprotein; Region: Flavoprotein; cl08021 431943002587 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 431943002588 Hexamer/Pentamer interface [polypeptide binding]; other site 431943002589 central pore; other site 431943002590 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 431943002591 SLBB domain; Region: SLBB; pfam10531 431943002592 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 431943002593 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 431943002594 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 431943002595 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 431943002596 putative hexamer interface [polypeptide binding]; other site 431943002597 putative hexagonal pore; other site 431943002598 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 431943002599 putative hexamer interface [polypeptide binding]; other site 431943002600 putative hexagonal pore; other site 431943002601 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 431943002602 SLBB domain; Region: SLBB; pfam10531 431943002603 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 431943002604 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 431943002605 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 431943002606 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 431943002607 putative hexamer interface [polypeptide binding]; other site 431943002608 putative hexagonal pore; other site 431943002609 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 431943002610 putative hexamer interface [polypeptide binding]; other site 431943002611 putative hexagonal pore; other site 431943002612 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 431943002613 SLBB domain; Region: SLBB; pfam10531 431943002614 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 431943002615 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 431943002616 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 431943002617 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 431943002618 putative hexamer interface [polypeptide binding]; other site 431943002619 putative hexagonal pore; other site 431943002620 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 431943002621 putative hexamer interface [polypeptide binding]; other site 431943002622 putative hexagonal pore; other site 431943002623 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 431943002624 SLBB domain; Region: SLBB; pfam10531 431943002625 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 431943002626 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 431943002627 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 431943002628 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 431943002629 putative hexamer interface [polypeptide binding]; other site 431943002630 putative hexagonal pore; other site 431943002631 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 431943002632 putative hexamer interface [polypeptide binding]; other site 431943002633 putative hexagonal pore; other site 431943002634 hypothetical protein; Provisional; Region: PRK04435 431943002635 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 431943002636 homoserine dehydrogenase; Provisional; Region: PRK06349 431943002637 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 431943002638 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 431943002639 homoserine kinase; Provisional; Region: PRK01212 431943002640 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 431943002641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 431943002642 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 431943002643 Maf-like protein; Reviewed; Region: PRK00078 431943002644 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 431943002645 dimer interface [polypeptide binding]; other site 431943002646 active site 431943002647 hypothetical protein; Reviewed; Region: PRK00024 431943002648 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 431943002649 helix-hairpin-helix signature motif; other site 431943002650 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 431943002651 MPN+ (JAMM) motif; other site 431943002652 Zinc-binding site [ion binding]; other site 431943002653 rod shape-determining protein MreB; Provisional; Region: PRK13927 431943002654 MreB and similar proteins; Region: MreB_like; cd10225 431943002655 nucleotide binding site [chemical binding]; other site 431943002656 Mg binding site [ion binding]; other site 431943002657 putative protofilament interaction site [polypeptide binding]; other site 431943002658 RodZ interaction site [polypeptide binding]; other site 431943002659 rod shape-determining protein MreC; Provisional; Region: PRK13922 431943002660 rod shape-determining protein MreC; Region: MreC; pfam04085 431943002661 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 431943002662 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943002663 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943002664 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943002665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943002666 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943002667 septum formation inhibitor; Reviewed; Region: minC; PRK00513 431943002668 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 431943002669 septum site-determining protein MinD; Region: minD_bact; TIGR01968 431943002670 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 431943002671 Switch I; other site 431943002672 Switch II; other site 431943002673 Septum formation topological specificity factor MinE; Region: MinE; cl00538 431943002674 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 431943002675 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 431943002676 Peptidase family M50; Region: Peptidase_M50; pfam02163 431943002677 active site 431943002678 putative substrate binding region [chemical binding]; other site 431943002679 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 431943002680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943002681 FeS/SAM binding site; other site 431943002682 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 431943002683 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 431943002684 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 431943002685 homodimer interface [polypeptide binding]; other site 431943002686 oligonucleotide binding site [chemical binding]; other site 431943002687 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 431943002688 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 431943002689 hypothetical protein; Provisional; Region: PRK14553 431943002690 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 431943002691 GTPase CgtA; Reviewed; Region: obgE; PRK12297 431943002692 GTP1/OBG; Region: GTP1_OBG; pfam01018 431943002693 Obg GTPase; Region: Obg; cd01898 431943002694 G1 box; other site 431943002695 GTP/Mg2+ binding site [chemical binding]; other site 431943002696 Switch I region; other site 431943002697 G2 box; other site 431943002698 G3 box; other site 431943002699 Switch II region; other site 431943002700 G4 box; other site 431943002701 G5 box; other site 431943002702 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 431943002703 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 431943002704 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 431943002705 active site 431943002706 (T/H)XGH motif; other site 431943002707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002708 Zn2+ binding site [ion binding]; other site 431943002709 Mg2+ binding site [ion binding]; other site 431943002710 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 431943002711 homotrimer interaction site [polypeptide binding]; other site 431943002712 putative active site [active] 431943002713 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 431943002714 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 431943002715 active site 431943002716 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 431943002717 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 431943002718 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 431943002719 SLBB domain; Region: SLBB; pfam10531 431943002720 comEA protein; Region: comE; TIGR01259 431943002721 Helix-hairpin-helix motif; Region: HHH; pfam00633 431943002722 aspartate aminotransferase; Provisional; Region: PRK06836 431943002723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943002724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943002725 homodimer interface [polypeptide binding]; other site 431943002726 catalytic residue [active] 431943002727 Predicted permeases [General function prediction only]; Region: COG0679 431943002728 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 431943002729 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943002730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943002731 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 431943002732 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 431943002733 Competence protein; Region: Competence; pfam03772 431943002734 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 431943002735 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 431943002736 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 431943002737 germination protease; Provisional; Region: PRK12362 431943002738 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 431943002739 stage II sporulation protein P; Region: spore_II_P; TIGR02867 431943002740 GTP-binding protein LepA; Provisional; Region: PRK05433 431943002741 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 431943002742 G1 box; other site 431943002743 putative GEF interaction site [polypeptide binding]; other site 431943002744 GTP/Mg2+ binding site [chemical binding]; other site 431943002745 Switch I region; other site 431943002746 G2 box; other site 431943002747 G3 box; other site 431943002748 Switch II region; other site 431943002749 G4 box; other site 431943002750 G5 box; other site 431943002751 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 431943002752 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 431943002753 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 431943002754 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 431943002755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943002756 FeS/SAM binding site; other site 431943002757 HemN C-terminal domain; Region: HemN_C; pfam06969 431943002758 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 431943002759 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 431943002760 GrpE; Region: GrpE; pfam01025 431943002761 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 431943002762 dimer interface [polypeptide binding]; other site 431943002763 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 431943002764 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 431943002765 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 431943002766 nucleotide binding site [chemical binding]; other site 431943002767 NEF interaction site [polypeptide binding]; other site 431943002768 SBD interface [polypeptide binding]; other site 431943002769 chaperone protein DnaJ; Provisional; Region: PRK14297 431943002770 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 431943002771 HSP70 interaction site [polypeptide binding]; other site 431943002772 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 431943002773 substrate binding site [polypeptide binding]; other site 431943002774 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 431943002775 Zn binding sites [ion binding]; other site 431943002776 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 431943002777 dimer interface [polypeptide binding]; other site 431943002778 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 431943002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943002780 S-adenosylmethionine binding site [chemical binding]; other site 431943002781 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 431943002782 RNA methyltransferase, RsmE family; Region: TIGR00046 431943002783 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 431943002784 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 431943002785 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 431943002786 nucleotide binding site/active site [active] 431943002787 HIT family signature motif; other site 431943002788 catalytic residue [active] 431943002789 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 431943002790 Yqey-like protein; Region: YqeY; cl17540 431943002791 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 431943002792 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 431943002793 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 431943002794 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 431943002795 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 431943002796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002797 Zn2+ binding site [ion binding]; other site 431943002798 Mg2+ binding site [ion binding]; other site 431943002799 metal-binding heat shock protein; Provisional; Region: PRK00016 431943002800 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 431943002801 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 431943002802 active site 431943002803 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 431943002804 active site 431943002805 catalytic motif [active] 431943002806 Zn binding site [ion binding]; other site 431943002807 GTPase Era; Reviewed; Region: era; PRK00089 431943002808 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 431943002809 G1 box; other site 431943002810 GTP/Mg2+ binding site [chemical binding]; other site 431943002811 Switch I region; other site 431943002812 G2 box; other site 431943002813 Switch II region; other site 431943002814 G3 box; other site 431943002815 G4 box; other site 431943002816 G5 box; other site 431943002817 KH domain; Region: KH_2; pfam07650 431943002818 Recombination protein O N terminal; Region: RecO_N; pfam11967 431943002819 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 431943002820 Recombination protein O C terminal; Region: RecO_C; pfam02565 431943002821 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 431943002822 HTH domain; Region: HTH_11; pfam08279 431943002823 FOG: CBS domain [General function prediction only]; Region: COG0517 431943002824 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 431943002825 pyruvate phosphate dikinase; Provisional; Region: PRK09279 431943002826 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 431943002827 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943002828 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 431943002829 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 431943002830 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 431943002831 putative ligand binding site [chemical binding]; other site 431943002832 putative NAD binding site [chemical binding]; other site 431943002833 catalytic site [active] 431943002834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943002835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943002836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943002837 dimerization interface [polypeptide binding]; other site 431943002838 gamma-glutamyl kinase; Provisional; Region: PRK05429 431943002839 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 431943002840 nucleotide binding site [chemical binding]; other site 431943002841 homotetrameric interface [polypeptide binding]; other site 431943002842 putative phosphate binding site [ion binding]; other site 431943002843 putative allosteric binding site; other site 431943002844 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943002845 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943002846 active site 431943002847 FMN binding site [chemical binding]; other site 431943002848 substrate binding site [chemical binding]; other site 431943002849 putative catalytic residue [active] 431943002850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943002851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943002852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943002853 B3/4 domain; Region: B3_4; pfam03483 431943002854 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943002855 EamA-like transporter family; Region: EamA; pfam00892 431943002856 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 431943002857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943002858 Predicted ATPase [General function prediction only]; Region: COG3910 431943002859 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 431943002860 Walker A/P-loop; other site 431943002861 ATP binding site [chemical binding]; other site 431943002862 Q-loop/lid; other site 431943002863 ABC transporter signature motif; other site 431943002864 Walker B; other site 431943002865 D-loop; other site 431943002866 H-loop/switch region; other site 431943002867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943002869 S-adenosylmethionine binding site [chemical binding]; other site 431943002870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 431943002871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 431943002872 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 431943002873 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 431943002874 4Fe-4S binding domain; Region: Fer4; pfam00037 431943002875 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 431943002876 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 431943002877 ligand binding site [chemical binding]; other site 431943002878 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 431943002879 non-specific DNA interactions [nucleotide binding]; other site 431943002880 DNA binding site [nucleotide binding] 431943002881 sequence specific DNA binding site [nucleotide binding]; other site 431943002882 putative cAMP binding site [chemical binding]; other site 431943002883 hybrid cluster protein; Provisional; Region: PRK05290 431943002884 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943002885 ACS interaction site; other site 431943002886 CODH interaction site; other site 431943002887 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 431943002888 hybrid metal cluster; other site 431943002889 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 431943002890 AAA domain; Region: AAA_26; pfam13500 431943002891 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 431943002892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943002893 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 431943002894 inhibitor-cofactor binding pocket; inhibition site 431943002895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943002896 catalytic residue [active] 431943002897 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 431943002898 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 431943002899 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 431943002900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943002901 Zn2+ binding site [ion binding]; other site 431943002902 Mg2+ binding site [ion binding]; other site 431943002903 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 431943002904 DNA primase; Validated; Region: dnaG; PRK05667 431943002905 CHC2 zinc finger; Region: zf-CHC2; pfam01807 431943002906 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 431943002907 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 431943002908 active site 431943002909 metal binding site [ion binding]; metal-binding site 431943002910 interdomain interaction site; other site 431943002911 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 431943002912 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 431943002913 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 431943002914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943002915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 431943002916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943002917 DNA binding residues [nucleotide binding] 431943002918 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 431943002919 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 431943002920 Family of unknown function (DUF633); Region: DUF633; pfam04816 431943002921 Uncharacterized conserved protein [Function unknown]; Region: COG0327 431943002922 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 431943002923 Putative zinc ribbon domain; Region: DUF164; pfam02591 431943002924 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 431943002925 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 431943002926 G1 box; other site 431943002927 GTP/Mg2+ binding site [chemical binding]; other site 431943002928 Switch I region; other site 431943002929 G2 box; other site 431943002930 G3 box; other site 431943002931 Switch II region; other site 431943002932 G4 box; other site 431943002933 G5 box; other site 431943002934 Nucleoside recognition; Region: Gate; pfam07670 431943002935 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 431943002936 Nucleoside recognition; Region: Gate; pfam07670 431943002937 FeoA domain; Region: FeoA; pfam04023 431943002938 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 431943002939 dihydropteroate synthase; Region: DHPS; TIGR01496 431943002940 substrate binding pocket [chemical binding]; other site 431943002941 dimer interface [polypeptide binding]; other site 431943002942 inhibitor binding site; inhibition site 431943002943 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 431943002944 homodecamer interface [polypeptide binding]; other site 431943002945 GTP cyclohydrolase I; Provisional; Region: PLN03044 431943002946 active site 431943002947 putative catalytic site residues [active] 431943002948 zinc binding site [ion binding]; other site 431943002949 GTP-CH-I/GFRP interaction surface; other site 431943002950 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 431943002951 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 431943002952 homooctamer interface [polypeptide binding]; other site 431943002953 active site 431943002954 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 431943002955 catalytic center binding site [active] 431943002956 ATP binding site [chemical binding]; other site 431943002957 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 431943002958 Active site serine [active] 431943002959 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 431943002960 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943002961 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943002962 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 431943002963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943002964 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 431943002965 Walker A/P-loop; other site 431943002966 ATP binding site [chemical binding]; other site 431943002967 Q-loop/lid; other site 431943002968 ABC transporter signature motif; other site 431943002969 Walker B; other site 431943002970 D-loop; other site 431943002971 H-loop/switch region; other site 431943002972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943002973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943002974 dimer interface [polypeptide binding]; other site 431943002975 phosphorylation site [posttranslational modification] 431943002976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943002977 ATP binding site [chemical binding]; other site 431943002978 G-X-G motif; other site 431943002979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943002980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943002981 active site 431943002982 phosphorylation site [posttranslational modification] 431943002983 intermolecular recognition site; other site 431943002984 dimerization interface [polypeptide binding]; other site 431943002985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943002986 DNA binding site [nucleotide binding] 431943002987 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 431943002988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 431943002989 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 431943002990 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 431943002991 putative acyl-acceptor binding pocket; other site 431943002992 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 431943002993 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 431943002994 active site 431943002995 catalytic residues [active] 431943002996 metal binding site [ion binding]; metal-binding site 431943002997 aconitate hydratase; Validated; Region: PRK07229 431943002998 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 431943002999 substrate binding site [chemical binding]; other site 431943003000 ligand binding site [chemical binding]; other site 431943003001 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 431943003002 substrate binding site [chemical binding]; other site 431943003003 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 431943003004 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943003005 homodimer interface [polypeptide binding]; other site 431943003006 substrate-cofactor binding pocket; other site 431943003007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003008 catalytic residue [active] 431943003009 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 431943003010 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 431943003011 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 431943003012 substrate binding pocket [chemical binding]; other site 431943003013 dimer interface [polypeptide binding]; other site 431943003014 inhibitor binding site; inhibition site 431943003015 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 431943003016 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 431943003017 B12 binding site [chemical binding]; other site 431943003018 cobalt ligand [ion binding]; other site 431943003019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943003020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 431943003021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943003022 substrate binding pocket [chemical binding]; other site 431943003023 membrane-bound complex binding site; other site 431943003024 hinge residues; other site 431943003025 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 431943003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003027 putative PBP binding loops; other site 431943003028 dimer interface [polypeptide binding]; other site 431943003029 ABC-ATPase subunit interface; other site 431943003030 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 431943003031 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 431943003032 Walker A/P-loop; other site 431943003033 ATP binding site [chemical binding]; other site 431943003034 Q-loop/lid; other site 431943003035 ABC transporter signature motif; other site 431943003036 Walker B; other site 431943003037 D-loop; other site 431943003038 H-loop/switch region; other site 431943003039 argininosuccinate synthase; Provisional; Region: PRK13820 431943003040 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 431943003041 ANP binding site [chemical binding]; other site 431943003042 Substrate Binding Site II [chemical binding]; other site 431943003043 Substrate Binding Site I [chemical binding]; other site 431943003044 argininosuccinate lyase; Provisional; Region: PRK00855 431943003045 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 431943003046 active sites [active] 431943003047 tetramer interface [polypeptide binding]; other site 431943003048 Uncharacterized conserved protein [Function unknown]; Region: COG2155 431943003049 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 431943003050 AsnC family; Region: AsnC_trans_reg; pfam01037 431943003051 asparagine synthetase A; Reviewed; Region: PRK06462 431943003052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 431943003053 motif 1; other site 431943003054 dimer interface [polypeptide binding]; other site 431943003055 active site 431943003056 motif 2; other site 431943003057 motif 3; other site 431943003058 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 431943003059 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 431943003060 trimer interface [polypeptide binding]; other site 431943003061 putative metal binding site [ion binding]; other site 431943003062 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943003063 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943003064 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 431943003065 putative active site [active] 431943003066 Zn binding site [ion binding]; other site 431943003067 Protein of unknown function (DUF327); Region: DUF327; pfam03885 431943003068 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 431943003069 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943003070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943003071 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 431943003072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943003073 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 431943003074 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 431943003075 S1 domain; Region: S1_2; pfam13509 431943003076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 431943003077 RNA binding site [nucleotide binding]; other site 431943003078 NAD synthetase; Reviewed; Region: nadE; PRK02628 431943003079 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 431943003080 multimer interface [polypeptide binding]; other site 431943003081 active site 431943003082 catalytic triad [active] 431943003083 protein interface 1 [polypeptide binding]; other site 431943003084 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 431943003085 homodimer interface [polypeptide binding]; other site 431943003086 NAD binding pocket [chemical binding]; other site 431943003087 ATP binding pocket [chemical binding]; other site 431943003088 Mg binding site [ion binding]; other site 431943003089 active-site loop [active] 431943003090 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 431943003091 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 431943003092 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 431943003093 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 431943003094 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 431943003095 active site 431943003096 Substrate binding site; other site 431943003097 Mg++ binding site; other site 431943003098 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 431943003099 putative trimer interface [polypeptide binding]; other site 431943003100 putative CoA binding site [chemical binding]; other site 431943003101 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 431943003102 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 431943003103 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 431943003104 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 431943003105 stationary phase survival protein SurE; Provisional; Region: PRK13933 431943003106 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 431943003107 active site 431943003108 intersubunit interactions; other site 431943003109 catalytic residue [active] 431943003110 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 431943003111 RNA polymerase sigma factor; Provisional; Region: PRK11924 431943003112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943003113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943003114 DNA binding residues [nucleotide binding] 431943003115 Methyltransferase domain; Region: Methyltransf_23; pfam13489 431943003116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943003117 S-adenosylmethionine binding site [chemical binding]; other site 431943003118 cystathionine beta-lyase; Provisional; Region: PRK07671 431943003119 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943003120 homodimer interface [polypeptide binding]; other site 431943003121 substrate-cofactor binding pocket; other site 431943003122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003123 catalytic residue [active] 431943003124 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 431943003125 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 431943003126 dimer interface [polypeptide binding]; other site 431943003127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003128 catalytic residue [active] 431943003129 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 431943003130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943003131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943003132 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 431943003133 active site 431943003134 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 431943003135 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 431943003136 Ligand binding site; other site 431943003137 metal-binding site 431943003138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943003139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943003140 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 431943003141 putative dimerization interface [polypeptide binding]; other site 431943003142 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 431943003143 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 431943003144 active site 431943003145 catalytic residue [active] 431943003146 dimer interface [polypeptide binding]; other site 431943003147 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 431943003148 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 431943003149 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 431943003150 shikimate binding site; other site 431943003151 NAD(P) binding site [chemical binding]; other site 431943003152 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943003153 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943003154 active site 431943003155 FMN binding site [chemical binding]; other site 431943003156 substrate binding site [chemical binding]; other site 431943003157 putative catalytic residue [active] 431943003158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943003159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943003160 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 431943003161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 431943003162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 431943003163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943003164 D-galactonate transporter; Region: 2A0114; TIGR00893 431943003165 putative substrate translocation pore; other site 431943003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943003167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943003168 putative substrate translocation pore; other site 431943003169 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 431943003170 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 431943003171 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 431943003172 shikimate binding site; other site 431943003173 NAD(P) binding site [chemical binding]; other site 431943003174 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 431943003175 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943003176 active site 431943003177 FMN binding site [chemical binding]; other site 431943003178 substrate binding site [chemical binding]; other site 431943003179 putative catalytic residue [active] 431943003180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 431943003181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943003182 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 431943003183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943003184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943003185 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 431943003186 putative dimerization interface [polypeptide binding]; other site 431943003187 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 431943003188 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 431943003189 inhibitor-cofactor binding pocket; inhibition site 431943003190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003191 catalytic residue [active] 431943003192 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 431943003193 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 431943003194 inhibitor-cofactor binding pocket; inhibition site 431943003195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003196 catalytic residue [active] 431943003197 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 431943003198 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943003199 DNA binding residues [nucleotide binding] 431943003200 dimer interface [polypeptide binding]; other site 431943003201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943003202 S-adenosylmethionine binding site [chemical binding]; other site 431943003203 Helix-turn-helix domain; Region: HTH_38; pfam13936 431943003204 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 431943003205 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 431943003206 active site 431943003207 HIGH motif; other site 431943003208 nucleotide binding site [chemical binding]; other site 431943003209 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 431943003210 KMSKS motif; other site 431943003211 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 431943003212 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943003213 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 431943003214 NodB motif; other site 431943003215 active site 431943003216 catalytic site [active] 431943003217 Zn binding site [ion binding]; other site 431943003218 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 431943003219 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 431943003220 active site 431943003221 dimer interface [polypeptide binding]; other site 431943003222 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 431943003223 Ligand Binding Site [chemical binding]; other site 431943003224 Molecular Tunnel; other site 431943003225 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 431943003226 dimer interface [polypeptide binding]; other site 431943003227 FMN binding site [chemical binding]; other site 431943003228 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 431943003229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943003230 Walker A motif; other site 431943003231 ATP binding site [chemical binding]; other site 431943003232 Walker B motif; other site 431943003233 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 431943003234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 431943003235 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 431943003236 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 431943003237 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 431943003238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943003239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003240 homodimer interface [polypeptide binding]; other site 431943003241 catalytic residue [active] 431943003242 L-asparaginase II; Region: Asparaginase_II; pfam06089 431943003243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943003244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943003245 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 431943003246 Walker A/P-loop; other site 431943003247 ATP binding site [chemical binding]; other site 431943003248 Q-loop/lid; other site 431943003249 ABC transporter signature motif; other site 431943003250 Walker B; other site 431943003251 D-loop; other site 431943003252 H-loop/switch region; other site 431943003253 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 431943003254 nitrogenase iron protein; Region: nifH; TIGR01287 431943003255 Nucleotide-binding sites [chemical binding]; other site 431943003256 Walker A motif; other site 431943003257 Switch I region of nucleotide binding site; other site 431943003258 Fe4S4 binding sites [ion binding]; other site 431943003259 Switch II region of nucleotide binding site; other site 431943003260 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003261 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003262 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003263 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003264 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 431943003265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943003266 FeS/SAM binding site; other site 431943003267 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 431943003268 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943003269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003270 dimer interface [polypeptide binding]; other site 431943003271 conserved gate region; other site 431943003272 putative PBP binding loops; other site 431943003273 ABC-ATPase subunit interface; other site 431943003274 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 431943003275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 431943003276 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 431943003277 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 431943003278 Walker A/P-loop; other site 431943003279 ATP binding site [chemical binding]; other site 431943003280 Q-loop/lid; other site 431943003281 ABC transporter signature motif; other site 431943003282 Walker B; other site 431943003283 D-loop; other site 431943003284 H-loop/switch region; other site 431943003285 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943003286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003287 dimer interface [polypeptide binding]; other site 431943003288 conserved gate region; other site 431943003289 putative PBP binding loops; other site 431943003290 ABC-ATPase subunit interface; other site 431943003291 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943003292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003293 putative PBP binding loops; other site 431943003294 dimer interface [polypeptide binding]; other site 431943003295 ABC-ATPase subunit interface; other site 431943003296 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003297 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003298 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003299 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003300 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003301 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003302 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 431943003303 nitrogenase iron protein; Region: nifH; TIGR01287 431943003304 Nucleotide-binding sites [chemical binding]; other site 431943003305 Walker A motif; other site 431943003306 Switch I region of nucleotide binding site; other site 431943003307 Fe4S4 binding sites [ion binding]; other site 431943003308 Switch II region of nucleotide binding site; other site 431943003309 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003310 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003311 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003312 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943003313 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943003314 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 431943003315 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 431943003316 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 431943003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003318 dimer interface [polypeptide binding]; other site 431943003319 conserved gate region; other site 431943003320 putative PBP binding loops; other site 431943003321 ABC-ATPase subunit interface; other site 431943003322 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 431943003323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943003324 dimer interface [polypeptide binding]; other site 431943003325 conserved gate region; other site 431943003326 putative PBP binding loops; other site 431943003327 ABC-ATPase subunit interface; other site 431943003328 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 431943003329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 431943003330 Walker A/P-loop; other site 431943003331 ATP binding site [chemical binding]; other site 431943003332 Q-loop/lid; other site 431943003333 ABC transporter signature motif; other site 431943003334 Walker B; other site 431943003335 D-loop; other site 431943003336 H-loop/switch region; other site 431943003337 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 431943003338 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 431943003339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 431943003340 Walker A/P-loop; other site 431943003341 ATP binding site [chemical binding]; other site 431943003342 Q-loop/lid; other site 431943003343 ABC transporter signature motif; other site 431943003344 Walker B; other site 431943003345 D-loop; other site 431943003346 H-loop/switch region; other site 431943003347 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 431943003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943003349 S-adenosylmethionine binding site [chemical binding]; other site 431943003350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943003351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943003352 active site 431943003353 phosphorylation site [posttranslational modification] 431943003354 intermolecular recognition site; other site 431943003355 dimerization interface [polypeptide binding]; other site 431943003356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943003357 DNA binding site [nucleotide binding] 431943003358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943003359 dimer interface [polypeptide binding]; other site 431943003360 phosphorylation site [posttranslational modification] 431943003361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943003362 ATP binding site [chemical binding]; other site 431943003363 G-X-G motif; other site 431943003364 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003365 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003366 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003367 Family description; Region: DsbD_2; pfam13386 431943003368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003369 dimer interface [polypeptide binding]; other site 431943003370 putative CheW interface [polypeptide binding]; other site 431943003371 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 431943003372 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 431943003373 active site 431943003374 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 431943003375 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 431943003376 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943003377 Spore germination protein; Region: Spore_permease; pfam03845 431943003378 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943003379 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943003380 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943003381 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 431943003382 dimer interface [polypeptide binding]; other site 431943003383 active site 431943003384 metal binding site [ion binding]; metal-binding site 431943003385 DNA topoisomerase III; Provisional; Region: PRK07726 431943003386 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 431943003387 active site 431943003388 putative interdomain interaction site [polypeptide binding]; other site 431943003389 putative metal-binding site [ion binding]; other site 431943003390 putative nucleotide binding site [chemical binding]; other site 431943003391 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 431943003392 domain I; other site 431943003393 DNA binding groove [nucleotide binding] 431943003394 phosphate binding site [ion binding]; other site 431943003395 domain II; other site 431943003396 domain III; other site 431943003397 nucleotide binding site [chemical binding]; other site 431943003398 catalytic site [active] 431943003399 domain IV; other site 431943003400 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 431943003401 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 431943003402 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 431943003403 dimer interface [polypeptide binding]; other site 431943003404 active site 431943003405 metal binding site [ion binding]; metal-binding site 431943003406 Response regulator receiver domain; Region: Response_reg; pfam00072 431943003407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943003408 active site 431943003409 phosphorylation site [posttranslational modification] 431943003410 intermolecular recognition site; other site 431943003411 dimerization interface [polypeptide binding]; other site 431943003412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943003413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943003414 Sensory domain found in PocR; Region: PocR; pfam10114 431943003415 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943003416 Histidine kinase; Region: His_kinase; pfam06580 431943003417 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 431943003418 ATP binding site [chemical binding]; other site 431943003419 Mg2+ binding site [ion binding]; other site 431943003420 G-X-G motif; other site 431943003421 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 431943003422 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 431943003423 Hexamer interface [polypeptide binding]; other site 431943003424 Putative hexagonal pore residue; other site 431943003425 propanediol utilization protein PduB; Provisional; Region: PRK15415 431943003426 Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]; Region: BDP1; COG5118 431943003427 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 431943003428 putative hexamer interface [polypeptide binding]; other site 431943003429 putative hexagonal pore; other site 431943003430 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 431943003431 putative hexamer interface [polypeptide binding]; other site 431943003432 putative hexagonal pore; other site 431943003433 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 431943003434 putative catalytic cysteine [active] 431943003435 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943003436 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 431943003437 putative active site [active] 431943003438 metal binding site [ion binding]; metal-binding site 431943003439 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 431943003440 putative catalytic cysteine [active] 431943003441 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943003442 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 431943003443 putative active site [active] 431943003444 metal binding site [ion binding]; metal-binding site 431943003445 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943003446 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 431943003447 putative active site [active] 431943003448 metal binding site [ion binding]; metal-binding site 431943003449 amino acid transporter; Region: 2A0306; TIGR00909 431943003450 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 431943003451 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 431943003452 ketol-acid reductoisomerase; Provisional; Region: PRK05479 431943003453 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 431943003454 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 431943003455 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 431943003456 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 431943003457 PYR/PP interface [polypeptide binding]; other site 431943003458 dimer interface [polypeptide binding]; other site 431943003459 TPP binding site [chemical binding]; other site 431943003460 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 431943003461 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 431943003462 TPP-binding site [chemical binding]; other site 431943003463 dimer interface [polypeptide binding]; other site 431943003464 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 431943003465 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 431943003466 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 431943003467 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003468 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003469 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003470 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943003471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943003472 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 431943003473 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 431943003474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943003475 catalytic residue [active] 431943003476 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 431943003477 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 431943003478 ketol-acid reductoisomerase; Provisional; Region: PRK05479 431943003479 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 431943003480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 431943003481 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 431943003482 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 431943003483 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 431943003484 metal ion-dependent adhesion site (MIDAS); other site 431943003485 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 431943003486 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 431943003487 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 431943003488 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943003489 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 431943003490 Protein export membrane protein; Region: SecD_SecF; cl14618 431943003491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943003492 MarR family; Region: MarR; pfam01047 431943003493 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 431943003494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 431943003495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 431943003496 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943003497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003498 dimer interface [polypeptide binding]; other site 431943003499 putative CheW interface [polypeptide binding]; other site 431943003500 Cache domain; Region: Cache_1; pfam02743 431943003501 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 431943003502 putative metal binding site; other site 431943003503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943003504 binding surface 431943003505 TPR motif; other site 431943003506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943003507 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003508 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003509 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003510 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943003511 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 431943003512 Leucine rich repeat; Region: LRR_8; pfam13855 431943003513 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943003514 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003515 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003516 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943003517 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943003518 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943003519 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943003520 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943003521 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943003522 homoserine dehydrogenase; Provisional; Region: PRK06349 431943003523 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 431943003524 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 431943003525 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 431943003526 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 431943003527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943003528 FeS/SAM binding site; other site 431943003529 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 431943003530 Pyruvate formate lyase 1; Region: PFL1; cd01678 431943003531 coenzyme A binding site [chemical binding]; other site 431943003532 active site 431943003533 catalytic residues [active] 431943003534 glycine loop; other site 431943003535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943003536 PAS domain; Region: PAS_9; pfam13426 431943003537 putative active site [active] 431943003538 heme pocket [chemical binding]; other site 431943003539 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 431943003540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943003541 putative active site [active] 431943003542 heme pocket [chemical binding]; other site 431943003543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943003544 dimer interface [polypeptide binding]; other site 431943003545 phosphorylation site [posttranslational modification] 431943003546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943003547 ATP binding site [chemical binding]; other site 431943003548 Mg2+ binding site [ion binding]; other site 431943003549 G-X-G motif; other site 431943003550 Response regulator receiver domain; Region: Response_reg; pfam00072 431943003551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943003552 active site 431943003553 phosphorylation site [posttranslational modification] 431943003554 intermolecular recognition site; other site 431943003555 dimerization interface [polypeptide binding]; other site 431943003556 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943003557 PAS fold; Region: PAS_3; pfam08447 431943003558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943003559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943003560 metal binding site [ion binding]; metal-binding site 431943003561 active site 431943003562 I-site; other site 431943003563 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 431943003564 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 431943003565 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 431943003566 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 431943003567 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 431943003568 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 431943003569 Walker A motif; other site 431943003570 ATP binding site [chemical binding]; other site 431943003571 Walker B motif; other site 431943003572 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 431943003573 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 431943003574 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 431943003575 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 431943003576 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 431943003577 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 431943003578 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 431943003579 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 431943003580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943003581 FeS/SAM binding site; other site 431943003582 Response regulator receiver domain; Region: Response_reg; pfam00072 431943003583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943003584 active site 431943003585 phosphorylation site [posttranslational modification] 431943003586 intermolecular recognition site; other site 431943003587 dimerization interface [polypeptide binding]; other site 431943003588 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 431943003589 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 431943003590 putative binding surface; other site 431943003591 active site 431943003592 P2 response regulator binding domain; Region: P2; pfam07194 431943003593 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 431943003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943003595 ATP binding site [chemical binding]; other site 431943003596 Mg2+ binding site [ion binding]; other site 431943003597 G-X-G motif; other site 431943003598 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 431943003599 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 431943003600 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943003601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943003602 dimerization interface [polypeptide binding]; other site 431943003603 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943003604 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003605 dimer interface [polypeptide binding]; other site 431943003606 putative CheW interface [polypeptide binding]; other site 431943003607 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 431943003608 Ligand Binding Site [chemical binding]; other site 431943003609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 431943003610 Ligand Binding Site [chemical binding]; other site 431943003611 Protein of unknown function (DUF441); Region: DUF441; pfam04284 431943003612 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 431943003613 TIGR04076 family protein; Region: TIGR04076 431943003614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003615 putative CheW interface [polypeptide binding]; other site 431943003616 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 431943003617 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 431943003618 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 431943003619 catalytic residues [active] 431943003620 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 431943003621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943003622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943003623 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943003624 magnesium transport protein MgtC; Provisional; Region: PRK15385 431943003625 MgtC family; Region: MgtC; pfam02308 431943003626 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 431943003627 trimer interface [polypeptide binding]; other site 431943003628 active site 431943003629 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 431943003630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 431943003631 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 431943003632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 431943003633 dimer interface [polypeptide binding]; other site 431943003634 active site 431943003635 metal binding site [ion binding]; metal-binding site 431943003636 glutathione binding site [chemical binding]; other site 431943003637 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 431943003638 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 431943003639 dimer interface [polypeptide binding]; other site 431943003640 ssDNA binding site [nucleotide binding]; other site 431943003641 tetramer (dimer of dimers) interface [polypeptide binding]; other site 431943003642 flagellin; Provisional; Region: PRK12804 431943003643 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 431943003644 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 431943003645 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 431943003646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943003647 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 431943003648 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943003649 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 431943003650 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 431943003651 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 431943003652 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 431943003653 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 431943003654 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 431943003655 FliG C-terminal domain; Region: FliG_C; pfam01706 431943003656 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 431943003657 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 431943003658 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 431943003659 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 431943003660 Walker A motif/ATP binding site; other site 431943003661 Walker B motif; other site 431943003662 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 431943003663 Flagellar FliJ protein; Region: FliJ; pfam02050 431943003664 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 431943003665 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 431943003666 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 431943003667 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 431943003668 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943003669 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 431943003670 Flagellar protein (FlbD); Region: FlbD; pfam06289 431943003671 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 431943003672 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 431943003673 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 431943003674 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 431943003675 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 431943003676 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 431943003677 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 431943003678 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 431943003679 FHIPEP family; Region: FHIPEP; pfam00771 431943003680 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 431943003681 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943003682 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 431943003683 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 431943003684 P-loop; other site 431943003685 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 431943003686 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 431943003687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943003688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 431943003689 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 431943003690 DNA binding residues [nucleotide binding] 431943003691 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 431943003692 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943003693 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 431943003694 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 431943003695 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943003696 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 431943003697 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 431943003698 Flagellar protein YcgR; Region: YcgR_2; pfam12945 431943003699 PilZ domain; Region: PilZ; pfam07238 431943003700 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 431943003701 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 431943003702 DRTGG domain; Region: DRTGG; pfam07085 431943003703 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 431943003704 DHHA2 domain; Region: DHHA2; pfam02833 431943003705 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943003706 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 431943003707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943003708 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 431943003709 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943003710 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 431943003711 AAA domain; Region: AAA_32; pfam13654 431943003712 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 431943003713 GTP-binding protein YchF; Reviewed; Region: PRK09601 431943003714 YchF GTPase; Region: YchF; cd01900 431943003715 G1 box; other site 431943003716 GTP/Mg2+ binding site [chemical binding]; other site 431943003717 Switch I region; other site 431943003718 G2 box; other site 431943003719 Switch II region; other site 431943003720 G3 box; other site 431943003721 G4 box; other site 431943003722 G5 box; other site 431943003723 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 431943003724 MraW methylase family; Region: Methyltransf_5; pfam01795 431943003725 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 431943003726 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 431943003727 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943003728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 431943003729 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 431943003730 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 431943003731 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943003732 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 431943003733 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 431943003734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 431943003735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943003736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 431943003737 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 431943003738 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 431943003739 Mg++ binding site [ion binding]; other site 431943003740 putative catalytic motif [active] 431943003741 putative substrate binding site [chemical binding]; other site 431943003742 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 431943003743 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 431943003744 Cell division protein FtsQ; Region: FtsQ; pfam03799 431943003745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 431943003746 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 431943003747 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 431943003748 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 431943003749 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 431943003750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 431943003751 catalytic residue [active] 431943003752 Protein of unknown function (DUF552); Region: DUF552; pfam04472 431943003753 YGGT family; Region: YGGT; pfam02325 431943003754 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 431943003755 DivIVA protein; Region: DivIVA; pfam05103 431943003756 DivIVA domain; Region: DivI1A_domain; TIGR03544 431943003757 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 431943003758 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 431943003759 lipoprotein signal peptidase; Provisional; Region: PRK14791 431943003760 lipoprotein signal peptidase; Provisional; Region: PRK14787 431943003761 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 431943003762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943003763 RNA binding surface [nucleotide binding]; other site 431943003764 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 431943003765 active site 431943003766 uracil transporter; Provisional; Region: PRK10720 431943003767 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 431943003768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943003769 active site 431943003770 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 431943003771 Domain of unknown function (DUF814); Region: DUF814; pfam05670 431943003772 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 431943003773 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 431943003774 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 431943003775 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 431943003776 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 431943003777 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 431943003778 Walker A motif; other site 431943003779 ATP binding site [chemical binding]; other site 431943003780 Walker B motif; other site 431943003781 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 431943003782 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 431943003783 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 431943003784 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 431943003785 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 431943003786 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 431943003787 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 431943003788 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 431943003789 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 431943003790 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 431943003791 active site 431943003792 elongation factor P; Validated; Region: PRK00529 431943003793 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 431943003794 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 431943003795 RNA binding site [nucleotide binding]; other site 431943003796 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 431943003797 RNA binding site [nucleotide binding]; other site 431943003798 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 431943003799 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 431943003800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 431943003801 Walker A motif; other site 431943003802 ATP binding site [chemical binding]; other site 431943003803 Walker B motif; other site 431943003804 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 431943003805 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 431943003806 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 431943003807 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 431943003808 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 431943003809 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 431943003810 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 431943003811 Asp23 family; Region: Asp23; pfam03780 431943003812 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 431943003813 putative RNA binding site [nucleotide binding]; other site 431943003814 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 431943003815 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 431943003816 generic binding surface II; other site 431943003817 generic binding surface I; other site 431943003818 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 431943003819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 431943003820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 431943003821 substrate binding pocket [chemical binding]; other site 431943003822 chain length determination region; other site 431943003823 substrate-Mg2+ binding site; other site 431943003824 catalytic residues [active] 431943003825 aspartate-rich region 1; other site 431943003826 active site lid residues [active] 431943003827 aspartate-rich region 2; other site 431943003828 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 431943003829 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 431943003830 TPP-binding site; other site 431943003831 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 431943003832 PYR/PP interface [polypeptide binding]; other site 431943003833 dimer interface [polypeptide binding]; other site 431943003834 TPP binding site [chemical binding]; other site 431943003835 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 431943003836 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 431943003837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943003838 RNA binding surface [nucleotide binding]; other site 431943003839 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 431943003840 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 431943003841 ATP-NAD kinase; Region: NAD_kinase; pfam01513 431943003842 arginine repressor; Provisional; Region: argR; PRK00441 431943003843 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 431943003844 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 431943003845 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 431943003846 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 431943003847 Walker A/P-loop; other site 431943003848 ATP binding site [chemical binding]; other site 431943003849 Q-loop/lid; other site 431943003850 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 431943003851 ABC transporter signature motif; other site 431943003852 Walker B; other site 431943003853 D-loop; other site 431943003854 H-loop/switch region; other site 431943003855 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 431943003856 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 431943003857 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 431943003858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943003859 active site 431943003860 phosphorylation site [posttranslational modification] 431943003861 intermolecular recognition site; other site 431943003862 dimerization interface [polypeptide binding]; other site 431943003863 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 431943003864 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 431943003865 dimer interface [polypeptide binding]; other site 431943003866 ADP-ribose binding site [chemical binding]; other site 431943003867 active site 431943003868 nudix motif; other site 431943003869 metal binding site [ion binding]; metal-binding site 431943003870 stage II sporulation protein M; Region: spo_II_M; TIGR02831 431943003871 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 431943003872 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943003873 active site 431943003874 DNA binding site [nucleotide binding] 431943003875 Int/Topo IB signature motif; other site 431943003876 phosphopentomutase; Provisional; Region: PRK05362 431943003877 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 431943003878 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 431943003879 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 431943003880 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 431943003881 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 431943003882 Protein of unknown function DUF86; Region: DUF86; pfam01934 431943003883 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943003884 active site 431943003885 NTP binding site [chemical binding]; other site 431943003886 metal binding triad [ion binding]; metal-binding site 431943003887 antibiotic binding site [chemical binding]; other site 431943003888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003889 dimer interface [polypeptide binding]; other site 431943003890 putative CheW interface [polypeptide binding]; other site 431943003891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943003892 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 431943003893 putative active site [active] 431943003894 heme pocket [chemical binding]; other site 431943003895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943003896 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 431943003897 putative active site [active] 431943003898 heme pocket [chemical binding]; other site 431943003899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943003900 putative active site [active] 431943003901 heme pocket [chemical binding]; other site 431943003902 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943003903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943003904 metal binding site [ion binding]; metal-binding site 431943003905 active site 431943003906 I-site; other site 431943003907 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943003908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943003909 Zn2+ binding site [ion binding]; other site 431943003910 Mg2+ binding site [ion binding]; other site 431943003911 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 431943003912 FMN binding site [chemical binding]; other site 431943003913 dimer interface [polypeptide binding]; other site 431943003914 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943003915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943003916 metal binding site [ion binding]; metal-binding site 431943003917 active site 431943003918 I-site; other site 431943003919 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943003920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943003921 Zn2+ binding site [ion binding]; other site 431943003922 Mg2+ binding site [ion binding]; other site 431943003923 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943003924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943003925 4Fe-4S binding domain; Region: Fer4; cl02805 431943003926 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943003927 Uncharacterized conserved protein [Function unknown]; Region: COG1751 431943003928 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 431943003929 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 431943003930 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 431943003931 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 431943003932 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 431943003933 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 431943003934 active site 431943003935 NTP binding site [chemical binding]; other site 431943003936 metal binding triad [ion binding]; metal-binding site 431943003937 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 431943003938 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 431943003939 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 431943003940 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 431943003941 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 431943003942 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 431943003943 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 431943003944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943003945 dimer interface [polypeptide binding]; other site 431943003946 putative CheW interface [polypeptide binding]; other site 431943003947 Sensory domain found in PocR; Region: PocR; pfam10114 431943003948 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943003949 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 431943003950 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 431943003951 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 431943003952 SLBB domain; Region: SLBB; pfam10531 431943003953 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 431943003954 FMN-binding domain; Region: FMN_bind; cl01081 431943003955 electron transport complex RsxE subunit; Provisional; Region: PRK12405 431943003956 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 431943003957 ferredoxin; Validated; Region: PRK07118 431943003958 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 431943003959 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 431943003960 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 431943003961 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 431943003962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943003963 active site 431943003964 motif I; other site 431943003965 motif II; other site 431943003966 SinI restriction endonuclease; Region: RE_SinI; pfam09570 431943003967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 431943003968 anthranilate synthase component I; Provisional; Region: PRK13570 431943003969 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 431943003970 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 431943003971 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 431943003972 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 431943003973 glutamine binding [chemical binding]; other site 431943003974 catalytic triad [active] 431943003975 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 431943003976 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 431943003977 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 431943003978 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 431943003979 active site 431943003980 ribulose/triose binding site [chemical binding]; other site 431943003981 phosphate binding site [ion binding]; other site 431943003982 substrate (anthranilate) binding pocket [chemical binding]; other site 431943003983 product (indole) binding pocket [chemical binding]; other site 431943003984 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 431943003985 active site 431943003986 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 431943003987 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 431943003988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943003989 catalytic residue [active] 431943003990 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 431943003991 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 431943003992 substrate binding site [chemical binding]; other site 431943003993 active site 431943003994 catalytic residues [active] 431943003995 heterodimer interface [polypeptide binding]; other site 431943003996 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 431943003997 putative homodimer interface [polypeptide binding]; other site 431943003998 putative homotetramer interface [polypeptide binding]; other site 431943003999 putative allosteric switch controlling residues; other site 431943004000 putative metal binding site [ion binding]; other site 431943004001 putative homodimer-homodimer interface [polypeptide binding]; other site 431943004002 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 431943004003 Uncharacterized conserved protein [Function unknown]; Region: COG2966 431943004004 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 431943004005 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 431943004006 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 431943004007 dimer interface [polypeptide binding]; other site 431943004008 active site 431943004009 glycine-pyridoxal phosphate binding site [chemical binding]; other site 431943004010 folate binding site [chemical binding]; other site 431943004011 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 431943004012 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 431943004013 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 431943004014 dimerization interface [polypeptide binding]; other site 431943004015 ATP binding site [chemical binding]; other site 431943004016 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 431943004017 dimerization interface [polypeptide binding]; other site 431943004018 ATP binding site [chemical binding]; other site 431943004019 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 431943004020 putative active site [active] 431943004021 catalytic triad [active] 431943004022 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 431943004023 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 431943004024 Walker A/P-loop; other site 431943004025 ATP binding site [chemical binding]; other site 431943004026 Q-loop/lid; other site 431943004027 ABC transporter signature motif; other site 431943004028 Walker B; other site 431943004029 D-loop; other site 431943004030 H-loop/switch region; other site 431943004031 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 431943004032 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943004033 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 431943004034 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943004035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 431943004036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943004037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004038 dimer interface [polypeptide binding]; other site 431943004039 phosphorylation site [posttranslational modification] 431943004040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004041 ATP binding site [chemical binding]; other site 431943004042 Mg2+ binding site [ion binding]; other site 431943004043 G-X-G motif; other site 431943004044 EDD domain protein, DegV family; Region: DegV; TIGR00762 431943004045 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 431943004046 Cache domain; Region: Cache_1; pfam02743 431943004047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943004048 dimerization interface [polypeptide binding]; other site 431943004049 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943004050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943004051 dimer interface [polypeptide binding]; other site 431943004052 putative CheW interface [polypeptide binding]; other site 431943004053 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 431943004054 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 431943004055 dimer interface [polypeptide binding]; other site 431943004056 motif 1; other site 431943004057 active site 431943004058 motif 2; other site 431943004059 motif 3; other site 431943004060 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 431943004061 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 431943004062 histidinol dehydrogenase; Region: hisD; TIGR00069 431943004063 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 431943004064 NAD binding site [chemical binding]; other site 431943004065 dimerization interface [polypeptide binding]; other site 431943004066 product binding site; other site 431943004067 substrate binding site [chemical binding]; other site 431943004068 zinc binding site [ion binding]; other site 431943004069 catalytic residues [active] 431943004070 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 431943004071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943004072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943004073 homodimer interface [polypeptide binding]; other site 431943004074 catalytic residue [active] 431943004075 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 431943004076 putative active site pocket [active] 431943004077 4-fold oligomerization interface [polypeptide binding]; other site 431943004078 metal binding residues [ion binding]; metal-binding site 431943004079 3-fold/trimer interface [polypeptide binding]; other site 431943004080 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 431943004081 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 431943004082 putative active site [active] 431943004083 oxyanion strand; other site 431943004084 catalytic triad [active] 431943004085 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 431943004086 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 431943004087 catalytic residues [active] 431943004088 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 431943004089 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 431943004090 substrate binding site [chemical binding]; other site 431943004091 glutamase interaction surface [polypeptide binding]; other site 431943004092 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 431943004093 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 431943004094 metal binding site [ion binding]; metal-binding site 431943004095 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 431943004096 active site 431943004097 histidinol-phosphatase; Provisional; Region: PRK05588 431943004098 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 431943004099 active site 431943004100 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 431943004101 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 431943004102 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 431943004103 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943004104 putative active site [active] 431943004105 putative metal binding site [ion binding]; other site 431943004106 recombination factor protein RarA; Reviewed; Region: PRK13342 431943004107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943004108 Walker A motif; other site 431943004109 ATP binding site [chemical binding]; other site 431943004110 Walker B motif; other site 431943004111 arginine finger; other site 431943004112 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 431943004113 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 431943004114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943004115 non-specific DNA binding site [nucleotide binding]; other site 431943004116 salt bridge; other site 431943004117 sequence-specific DNA binding site [nucleotide binding]; other site 431943004118 Cupin domain; Region: Cupin_2; pfam07883 431943004119 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 431943004120 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 431943004121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 431943004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943004123 dimer interface [polypeptide binding]; other site 431943004124 conserved gate region; other site 431943004125 putative PBP binding loops; other site 431943004126 ABC-ATPase subunit interface; other site 431943004127 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 431943004128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943004129 dimer interface [polypeptide binding]; other site 431943004130 conserved gate region; other site 431943004131 putative PBP binding loops; other site 431943004132 ABC-ATPase subunit interface; other site 431943004133 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 431943004134 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 431943004135 Walker A/P-loop; other site 431943004136 ATP binding site [chemical binding]; other site 431943004137 Q-loop/lid; other site 431943004138 ABC transporter signature motif; other site 431943004139 Walker B; other site 431943004140 D-loop; other site 431943004141 H-loop/switch region; other site 431943004142 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 431943004143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 431943004144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 431943004145 Walker A/P-loop; other site 431943004146 ATP binding site [chemical binding]; other site 431943004147 Q-loop/lid; other site 431943004148 ABC transporter signature motif; other site 431943004149 Walker B; other site 431943004150 D-loop; other site 431943004151 H-loop/switch region; other site 431943004152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 431943004153 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 431943004154 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 431943004155 active site 431943004156 dimer interface [polypeptide binding]; other site 431943004157 Transcriptional regulator; Region: Rrf2; cl17282 431943004158 Rrf2 family protein; Region: rrf2_super; TIGR00738 431943004159 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 431943004160 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 431943004161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943004162 catalytic residue [active] 431943004163 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 431943004164 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 431943004165 trimerization site [polypeptide binding]; other site 431943004166 active site 431943004167 PRC-barrel domain; Region: PRC; pfam05239 431943004168 PRC-barrel domain; Region: PRC; pfam05239 431943004169 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 431943004170 Domain of unknown function DUF20; Region: UPF0118; pfam01594 431943004171 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943004172 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943004173 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943004174 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 431943004175 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 431943004176 motif 1; other site 431943004177 active site 431943004178 motif 2; other site 431943004179 motif 3; other site 431943004180 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 431943004181 hypothetical protein; Provisional; Region: PRK05473 431943004182 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 431943004183 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 431943004184 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943004185 metal binding site 2 [ion binding]; metal-binding site 431943004186 putative DNA binding helix; other site 431943004187 metal binding site 1 [ion binding]; metal-binding site 431943004188 dimer interface [polypeptide binding]; other site 431943004189 structural Zn2+ binding site [ion binding]; other site 431943004190 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 431943004191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943004192 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 431943004193 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 431943004194 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 431943004195 G1 box; other site 431943004196 putative GEF interaction site [polypeptide binding]; other site 431943004197 GTP/Mg2+ binding site [chemical binding]; other site 431943004198 Switch I region; other site 431943004199 G2 box; other site 431943004200 G3 box; other site 431943004201 Switch II region; other site 431943004202 G4 box; other site 431943004203 G5 box; other site 431943004204 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 431943004205 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 431943004206 YceG-like family; Region: YceG; pfam02618 431943004207 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 431943004208 dimerization interface [polypeptide binding]; other site 431943004209 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 431943004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943004211 S-adenosylmethionine binding site [chemical binding]; other site 431943004212 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 431943004213 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 431943004214 Peptidase family U32; Region: Peptidase_U32; pfam01136 431943004215 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 431943004216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 431943004217 sporulation sigma factor SigK; Reviewed; Region: PRK05803 431943004218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943004219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943004220 DNA binding residues [nucleotide binding] 431943004221 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 431943004222 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 431943004223 Walker A motif; other site 431943004224 ATP binding site [chemical binding]; other site 431943004225 Walker B motif; other site 431943004226 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 431943004227 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 431943004228 DXD motif; other site 431943004229 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 431943004230 Cell division protein FtsA; Region: FtsA; smart00842 431943004231 Cell division protein FtsA; Region: FtsA; pfam14450 431943004232 cell division protein FtsZ; Validated; Region: PRK09330 431943004233 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 431943004234 nucleotide binding site [chemical binding]; other site 431943004235 SulA interaction site; other site 431943004236 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 431943004237 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 431943004238 sporulation sigma factor SigE; Reviewed; Region: PRK08301 431943004239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943004240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943004241 DNA binding residues [nucleotide binding] 431943004242 sporulation sigma factor SigG; Reviewed; Region: PRK08215 431943004243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943004244 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 431943004245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943004246 DNA binding residues [nucleotide binding] 431943004247 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 431943004248 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 431943004249 ATP cone domain; Region: ATP-cone; pfam03477 431943004250 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 431943004251 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 431943004252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943004253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943004254 active site 431943004255 phosphorylation site [posttranslational modification] 431943004256 intermolecular recognition site; other site 431943004257 dimerization interface [polypeptide binding]; other site 431943004258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943004259 DNA binding site [nucleotide binding] 431943004260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943004261 dimerization interface [polypeptide binding]; other site 431943004262 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 431943004263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943004264 putative active site [active] 431943004265 heme pocket [chemical binding]; other site 431943004266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004267 dimer interface [polypeptide binding]; other site 431943004268 phosphorylation site [posttranslational modification] 431943004269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004270 ATP binding site [chemical binding]; other site 431943004271 Mg2+ binding site [ion binding]; other site 431943004272 G-X-G motif; other site 431943004273 PBP superfamily domain; Region: PBP_like_2; cl17296 431943004274 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 431943004275 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 431943004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943004277 dimer interface [polypeptide binding]; other site 431943004278 conserved gate region; other site 431943004279 putative PBP binding loops; other site 431943004280 ABC-ATPase subunit interface; other site 431943004281 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 431943004282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943004283 dimer interface [polypeptide binding]; other site 431943004284 conserved gate region; other site 431943004285 putative PBP binding loops; other site 431943004286 ABC-ATPase subunit interface; other site 431943004287 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 431943004288 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 431943004289 Walker A/P-loop; other site 431943004290 ATP binding site [chemical binding]; other site 431943004291 Q-loop/lid; other site 431943004292 ABC transporter signature motif; other site 431943004293 Walker B; other site 431943004294 D-loop; other site 431943004295 H-loop/switch region; other site 431943004296 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 431943004297 PhoU domain; Region: PhoU; pfam01895 431943004298 PhoU domain; Region: PhoU; pfam01895 431943004299 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 431943004300 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 431943004301 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 431943004302 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 431943004303 Protein of unknown function (DUF512); Region: DUF512; pfam04459 431943004304 GTP-binding protein Der; Reviewed; Region: PRK00093 431943004305 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 431943004306 G1 box; other site 431943004307 GTP/Mg2+ binding site [chemical binding]; other site 431943004308 Switch I region; other site 431943004309 G2 box; other site 431943004310 Switch II region; other site 431943004311 G3 box; other site 431943004312 G4 box; other site 431943004313 G5 box; other site 431943004314 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 431943004315 G1 box; other site 431943004316 GTP/Mg2+ binding site [chemical binding]; other site 431943004317 Switch I region; other site 431943004318 G2 box; other site 431943004319 G3 box; other site 431943004320 Switch II region; other site 431943004321 G4 box; other site 431943004322 G5 box; other site 431943004323 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 431943004324 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 431943004325 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 431943004326 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 431943004327 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 431943004328 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 431943004329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943004331 active site 431943004332 phosphorylation site [posttranslational modification] 431943004333 intermolecular recognition site; other site 431943004334 dimerization interface [polypeptide binding]; other site 431943004335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943004336 DNA binding site [nucleotide binding] 431943004337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943004338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943004339 dimerization interface [polypeptide binding]; other site 431943004340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004341 dimer interface [polypeptide binding]; other site 431943004342 phosphorylation site [posttranslational modification] 431943004343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004344 ATP binding site [chemical binding]; other site 431943004345 Mg2+ binding site [ion binding]; other site 431943004346 G-X-G motif; other site 431943004347 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 431943004348 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 431943004349 Ligand binding site; other site 431943004350 Putative Catalytic site; other site 431943004351 DXD motif; other site 431943004352 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 431943004353 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 431943004354 hypothetical protein; Provisional; Region: PRK11820 431943004355 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 431943004356 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 431943004357 hypothetical protein; Provisional; Region: PRK04323 431943004358 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 431943004359 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 431943004360 catalytic site [active] 431943004361 G-X2-G-X-G-K; other site 431943004362 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 431943004363 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 431943004364 Flavoprotein; Region: Flavoprotein; pfam02441 431943004365 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 431943004366 primosome assembly protein PriA; Validated; Region: PRK05580 431943004367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943004368 ATP binding site [chemical binding]; other site 431943004369 putative Mg++ binding site [ion binding]; other site 431943004370 helicase superfamily c-terminal domain; Region: HELICc; smart00490 431943004371 ATP-binding site [chemical binding]; other site 431943004372 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 431943004373 active site 431943004374 catalytic residues [active] 431943004375 metal binding site [ion binding]; metal-binding site 431943004376 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 431943004377 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 431943004378 putative active site [active] 431943004379 substrate binding site [chemical binding]; other site 431943004380 putative cosubstrate binding site; other site 431943004381 catalytic site [active] 431943004382 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 431943004383 substrate binding site [chemical binding]; other site 431943004384 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 431943004385 16S rRNA methyltransferase B; Provisional; Region: PRK14902 431943004386 NusB family; Region: NusB; pfam01029 431943004387 putative RNA binding site [nucleotide binding]; other site 431943004388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943004389 S-adenosylmethionine binding site [chemical binding]; other site 431943004390 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 431943004391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943004392 FeS/SAM binding site; other site 431943004393 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 431943004394 Protein phosphatase 2C; Region: PP2C; pfam00481 431943004395 active site 431943004396 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 431943004397 Catalytic domain of Protein Kinases; Region: PKc; cd00180 431943004398 active site 431943004399 ATP binding site [chemical binding]; other site 431943004400 substrate binding site [chemical binding]; other site 431943004401 activation loop (A-loop); other site 431943004402 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 431943004403 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 431943004404 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 431943004405 GTPase RsgA; Reviewed; Region: PRK00098 431943004406 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 431943004407 RNA binding site [nucleotide binding]; other site 431943004408 homodimer interface [polypeptide binding]; other site 431943004409 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 431943004410 GTPase/Zn-binding domain interface [polypeptide binding]; other site 431943004411 GTP/Mg2+ binding site [chemical binding]; other site 431943004412 G4 box; other site 431943004413 G5 box; other site 431943004414 G1 box; other site 431943004415 Switch I region; other site 431943004416 G2 box; other site 431943004417 G3 box; other site 431943004418 Switch II region; other site 431943004419 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 431943004420 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 431943004421 substrate binding site [chemical binding]; other site 431943004422 hexamer interface [polypeptide binding]; other site 431943004423 metal binding site [ion binding]; metal-binding site 431943004424 Thiamine pyrophosphokinase; Region: TPK; cd07995 431943004425 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 431943004426 active site 431943004427 dimerization interface [polypeptide binding]; other site 431943004428 thiamine binding site [chemical binding]; other site 431943004429 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 431943004430 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 431943004431 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 431943004432 NAD binding site [chemical binding]; other site 431943004433 dimer interface [polypeptide binding]; other site 431943004434 substrate binding site [chemical binding]; other site 431943004435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 431943004436 Asp23 family; Region: Asp23; pfam03780 431943004437 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 431943004438 DAK2 domain; Region: Dak2; pfam02734 431943004439 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 431943004440 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 431943004441 ssDNA binding site; other site 431943004442 generic binding surface II; other site 431943004443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943004444 ATP binding site [chemical binding]; other site 431943004445 putative Mg++ binding site [ion binding]; other site 431943004446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943004447 nucleotide binding region [chemical binding]; other site 431943004448 ATP-binding site [chemical binding]; other site 431943004449 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 431943004450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943004451 S-adenosylmethionine binding site [chemical binding]; other site 431943004452 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 431943004453 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 431943004454 active site 431943004455 (T/H)XGH motif; other site 431943004456 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 431943004457 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 431943004458 hypothetical protein; Provisional; Region: PRK13670 431943004459 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 431943004460 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 431943004461 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 431943004462 propionate/acetate kinase; Provisional; Region: PRK12379 431943004463 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 431943004464 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 431943004465 putative phosphate acyltransferase; Provisional; Region: PRK05331 431943004466 acyl carrier protein; Provisional; Region: acpP; PRK00982 431943004467 ribonuclease III; Reviewed; Region: rnc; PRK00102 431943004468 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 431943004469 dimerization interface [polypeptide binding]; other site 431943004470 active site 431943004471 metal binding site [ion binding]; metal-binding site 431943004472 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 431943004473 dsRNA binding site [nucleotide binding]; other site 431943004474 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 431943004475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943004476 FeS/SAM binding site; other site 431943004477 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 431943004478 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 431943004479 Walker A/P-loop; other site 431943004480 ATP binding site [chemical binding]; other site 431943004481 Q-loop/lid; other site 431943004482 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 431943004483 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 431943004484 ABC transporter signature motif; other site 431943004485 Walker B; other site 431943004486 D-loop; other site 431943004487 H-loop/switch region; other site 431943004488 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 431943004489 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 431943004490 P loop; other site 431943004491 GTP binding site [chemical binding]; other site 431943004492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943004493 DNA binding residues [nucleotide binding] 431943004494 signal recognition particle protein; Provisional; Region: PRK10867 431943004495 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 431943004496 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 431943004497 P loop; other site 431943004498 GTP binding site [chemical binding]; other site 431943004499 Signal peptide binding domain; Region: SRP_SPB; pfam02978 431943004500 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 431943004501 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 431943004502 hypothetical protein; Provisional; Region: PRK00468 431943004503 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 431943004504 RimM N-terminal domain; Region: RimM; pfam01782 431943004505 PRC-barrel domain; Region: PRC; pfam05239 431943004506 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 431943004507 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 431943004508 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 431943004509 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 431943004510 Catalytic site [active] 431943004511 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 431943004512 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 431943004513 GTP/Mg2+ binding site [chemical binding]; other site 431943004514 G4 box; other site 431943004515 G5 box; other site 431943004516 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 431943004517 G1 box; other site 431943004518 G1 box; other site 431943004519 GTP/Mg2+ binding site [chemical binding]; other site 431943004520 Switch I region; other site 431943004521 G2 box; other site 431943004522 G2 box; other site 431943004523 G3 box; other site 431943004524 G3 box; other site 431943004525 Switch II region; other site 431943004526 Switch II region; other site 431943004527 G4 box; other site 431943004528 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 431943004529 RNA/DNA hybrid binding site [nucleotide binding]; other site 431943004530 active site 431943004531 hypothetical protein; Reviewed; Region: PRK12497 431943004532 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 431943004533 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 431943004534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943004535 Walker A motif; other site 431943004536 ATP binding site [chemical binding]; other site 431943004537 Walker B motif; other site 431943004538 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 431943004539 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 431943004540 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 431943004541 AP (apurinic/apyrimidinic) site pocket; other site 431943004542 DNA interaction; other site 431943004543 Metal-binding active site; metal-binding site 431943004544 DNA protecting protein DprA; Region: dprA; TIGR00732 431943004545 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 431943004546 DNA topoisomerase I; Validated; Region: PRK05582 431943004547 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 431943004548 active site 431943004549 interdomain interaction site; other site 431943004550 putative metal-binding site [ion binding]; other site 431943004551 nucleotide binding site [chemical binding]; other site 431943004552 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 431943004553 domain I; other site 431943004554 DNA binding groove [nucleotide binding] 431943004555 phosphate binding site [ion binding]; other site 431943004556 domain II; other site 431943004557 domain III; other site 431943004558 nucleotide binding site [chemical binding]; other site 431943004559 catalytic site [active] 431943004560 domain IV; other site 431943004561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 431943004562 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 431943004563 transcriptional repressor CodY; Validated; Region: PRK04158 431943004564 CodY GAF-like domain; Region: CodY; pfam06018 431943004565 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 431943004566 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 431943004567 rRNA interaction site [nucleotide binding]; other site 431943004568 S8 interaction site; other site 431943004569 putative laminin-1 binding site; other site 431943004570 elongation factor Ts; Provisional; Region: tsf; PRK09377 431943004571 UBA/TS-N domain; Region: UBA; pfam00627 431943004572 Elongation factor TS; Region: EF_TS; pfam00889 431943004573 Elongation factor TS; Region: EF_TS; pfam00889 431943004574 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 431943004575 putative nucleotide binding site [chemical binding]; other site 431943004576 uridine monophosphate binding site [chemical binding]; other site 431943004577 homohexameric interface [polypeptide binding]; other site 431943004578 ribosome recycling factor; Reviewed; Region: frr; PRK00083 431943004579 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 431943004580 hinge region; other site 431943004581 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 431943004582 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 431943004583 catalytic residue [active] 431943004584 putative FPP diphosphate binding site; other site 431943004585 putative FPP binding hydrophobic cleft; other site 431943004586 dimer interface [polypeptide binding]; other site 431943004587 putative IPP diphosphate binding site; other site 431943004588 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 431943004589 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 431943004590 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 431943004591 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 431943004592 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 431943004593 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 431943004594 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 431943004595 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 431943004596 active site 431943004597 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 431943004598 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 431943004599 putative substrate binding region [chemical binding]; other site 431943004600 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 431943004601 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 431943004602 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 431943004603 DNA polymerase III PolC; Validated; Region: polC; PRK00448 431943004604 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 431943004605 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 431943004606 generic binding surface II; other site 431943004607 generic binding surface I; other site 431943004608 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 431943004609 active site 431943004610 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 431943004611 active site 431943004612 catalytic site [active] 431943004613 substrate binding site [chemical binding]; other site 431943004614 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 431943004615 ribosome maturation protein RimP; Reviewed; Region: PRK00092 431943004616 Sm and related proteins; Region: Sm_like; cl00259 431943004617 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 431943004618 putative oligomer interface [polypeptide binding]; other site 431943004619 putative RNA binding site [nucleotide binding]; other site 431943004620 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 431943004621 NusA N-terminal domain; Region: NusA_N; pfam08529 431943004622 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 431943004623 RNA binding site [nucleotide binding]; other site 431943004624 homodimer interface [polypeptide binding]; other site 431943004625 NusA-like KH domain; Region: KH_5; pfam13184 431943004626 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 431943004627 G-X-X-G motif; other site 431943004628 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 431943004629 putative RNA binding cleft [nucleotide binding]; other site 431943004630 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 431943004631 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 431943004632 translation initiation factor IF-2; Region: IF-2; TIGR00487 431943004633 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 431943004634 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 431943004635 G1 box; other site 431943004636 putative GEF interaction site [polypeptide binding]; other site 431943004637 GTP/Mg2+ binding site [chemical binding]; other site 431943004638 Switch I region; other site 431943004639 G2 box; other site 431943004640 G3 box; other site 431943004641 Switch II region; other site 431943004642 G4 box; other site 431943004643 G5 box; other site 431943004644 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 431943004645 Translation-initiation factor 2; Region: IF-2; pfam11987 431943004646 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 431943004647 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 431943004648 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 431943004649 DHH family; Region: DHH; pfam01368 431943004650 DHHA1 domain; Region: DHHA1; pfam02272 431943004651 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 431943004652 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 431943004653 RNA binding site [nucleotide binding]; other site 431943004654 active site 431943004655 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 431943004656 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 431943004657 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 431943004658 active site 431943004659 Riboflavin kinase; Region: Flavokinase; pfam01687 431943004660 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 431943004661 16S/18S rRNA binding site [nucleotide binding]; other site 431943004662 S13e-L30e interaction site [polypeptide binding]; other site 431943004663 25S rRNA binding site [nucleotide binding]; other site 431943004664 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 431943004665 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 431943004666 RNase E interface [polypeptide binding]; other site 431943004667 trimer interface [polypeptide binding]; other site 431943004668 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 431943004669 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 431943004670 RNase E interface [polypeptide binding]; other site 431943004671 trimer interface [polypeptide binding]; other site 431943004672 active site 431943004673 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 431943004674 putative nucleic acid binding region [nucleotide binding]; other site 431943004675 G-X-X-G motif; other site 431943004676 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 431943004677 RNA binding site [nucleotide binding]; other site 431943004678 domain interface; other site 431943004679 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 431943004680 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 431943004681 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 431943004682 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 431943004683 aspartate kinase I; Reviewed; Region: PRK08210 431943004684 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 431943004685 nucleotide binding site [chemical binding]; other site 431943004686 substrate binding site [chemical binding]; other site 431943004687 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 431943004688 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 431943004689 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 431943004690 Clp protease; Region: CLP_protease; pfam00574 431943004691 active site 431943004692 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 431943004693 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 431943004694 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 431943004695 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 431943004696 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 431943004697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943004698 FeS/SAM binding site; other site 431943004699 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 431943004700 recombinase A; Provisional; Region: recA; PRK09354 431943004701 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 431943004702 hexamer interface [polypeptide binding]; other site 431943004703 Walker A motif; other site 431943004704 ATP binding site [chemical binding]; other site 431943004705 Walker B motif; other site 431943004706 phosphodiesterase; Provisional; Region: PRK12704 431943004707 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 431943004708 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943004709 Zn2+ binding site [ion binding]; other site 431943004710 Mg2+ binding site [ion binding]; other site 431943004711 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 431943004712 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 431943004713 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 431943004714 aspartate aminotransferase; Provisional; Region: PRK05764 431943004715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943004716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943004717 homodimer interface [polypeptide binding]; other site 431943004718 catalytic residue [active] 431943004719 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 431943004720 dimerization domain swap beta strand [polypeptide binding]; other site 431943004721 regulatory protein interface [polypeptide binding]; other site 431943004722 active site 431943004723 regulatory phosphorylation site [posttranslational modification]; other site 431943004724 Domain of unknown function (DUF378); Region: DUF378; cl00943 431943004725 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 431943004726 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 431943004727 tetramer interface [polypeptide binding]; other site 431943004728 active site 431943004729 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 431943004730 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 431943004731 active site 431943004732 HIGH motif; other site 431943004733 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 431943004734 active site 431943004735 KMSKS motif; other site 431943004736 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 431943004737 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 431943004738 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 431943004739 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 431943004740 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 431943004741 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 431943004742 putative active site [active] 431943004743 putative CoA binding site [chemical binding]; other site 431943004744 nudix motif; other site 431943004745 metal binding site [ion binding]; metal-binding site 431943004746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943004747 MarR family; Region: MarR_2; pfam12802 431943004748 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943004749 MarR family; Region: MarR_2; cl17246 431943004750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943004751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943004752 putative substrate translocation pore; other site 431943004753 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 431943004754 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 431943004755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004756 dimer interface [polypeptide binding]; other site 431943004757 phosphorylation site [posttranslational modification] 431943004758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004759 ATP binding site [chemical binding]; other site 431943004760 Mg2+ binding site [ion binding]; other site 431943004761 G-X-G motif; other site 431943004762 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 431943004763 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 431943004764 active site 431943004765 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 431943004766 Part of AAA domain; Region: AAA_19; pfam13245 431943004767 AAA domain; Region: AAA_14; pfam13173 431943004768 Family description; Region: UvrD_C_2; pfam13538 431943004769 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 431943004770 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 431943004771 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 431943004772 Ligand Binding Site [chemical binding]; other site 431943004773 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 431943004774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004775 dimer interface [polypeptide binding]; other site 431943004776 phosphorylation site [posttranslational modification] 431943004777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004778 ATP binding site [chemical binding]; other site 431943004779 Mg2+ binding site [ion binding]; other site 431943004780 G-X-G motif; other site 431943004781 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 431943004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943004783 active site 431943004784 phosphorylation site [posttranslational modification] 431943004785 intermolecular recognition site; other site 431943004786 dimerization interface [polypeptide binding]; other site 431943004787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943004788 DNA binding site [nucleotide binding] 431943004789 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 431943004790 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 431943004791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943004792 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943004793 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 431943004794 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 431943004795 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 431943004796 Isochorismatase family; Region: Isochorismatase; pfam00857 431943004797 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 431943004798 catalytic triad [active] 431943004799 dimer interface [polypeptide binding]; other site 431943004800 conserved cis-peptide bond; other site 431943004801 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943004802 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943004803 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943004804 dimer interface [polypeptide binding]; other site 431943004805 putative CheW interface [polypeptide binding]; other site 431943004806 cell division protein FtsA; Region: ftsA; TIGR01174 431943004807 Cell division protein FtsA; Region: FtsA; smart00842 431943004808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 431943004809 nucleotide binding site [chemical binding]; other site 431943004810 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 431943004811 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 431943004812 metal binding site [ion binding]; metal-binding site 431943004813 dimer interface [polypeptide binding]; other site 431943004814 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 431943004815 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943004816 RNA binding surface [nucleotide binding]; other site 431943004817 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 431943004818 active site 431943004819 stage V sporulation protein B; Region: spore_V_B; TIGR02900 431943004820 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 431943004821 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 431943004822 putative efflux protein, MATE family; Region: matE; TIGR00797 431943004823 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 431943004824 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 431943004825 Zn binding site [ion binding]; other site 431943004826 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 431943004827 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 431943004828 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 431943004829 HPr kinase/phosphorylase; Provisional; Region: PRK05428 431943004830 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 431943004831 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 431943004832 Hpr binding site; other site 431943004833 active site 431943004834 homohexamer subunit interaction site [polypeptide binding]; other site 431943004835 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 431943004836 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 431943004837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943004838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943004839 putative substrate translocation pore; other site 431943004840 Protease prsW family; Region: PrsW-protease; pfam13367 431943004841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943004842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943004843 active site 431943004844 phosphorylation site [posttranslational modification] 431943004845 intermolecular recognition site; other site 431943004846 dimerization interface [polypeptide binding]; other site 431943004847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943004848 DNA binding site [nucleotide binding] 431943004849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943004850 HAMP domain; Region: HAMP; pfam00672 431943004851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943004852 dimer interface [polypeptide binding]; other site 431943004853 phosphorylation site [posttranslational modification] 431943004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943004855 ATP binding site [chemical binding]; other site 431943004856 Mg2+ binding site [ion binding]; other site 431943004857 G-X-G motif; other site 431943004858 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 431943004859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943004860 S-adenosylmethionine binding site [chemical binding]; other site 431943004861 CAAX protease self-immunity; Region: Abi; pfam02517 431943004862 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 431943004863 UbiA prenyltransferase family; Region: UbiA; pfam01040 431943004864 oxidoreductase; Provisional; Region: PRK10015 431943004865 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 431943004866 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 431943004867 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 431943004868 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 431943004869 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 431943004870 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 431943004871 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 431943004872 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 431943004873 acyl-activating enzyme (AAE) consensus motif; other site 431943004874 active site 431943004875 AMP binding site [chemical binding]; other site 431943004876 substrate binding site [chemical binding]; other site 431943004877 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 431943004878 Condensation domain; Region: Condensation; pfam00668 431943004879 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943004880 Nonribosomal peptide synthase; Region: NRPS; pfam08415 431943004881 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 431943004882 acyl-activating enzyme (AAE) consensus motif; other site 431943004883 AMP binding site [chemical binding]; other site 431943004884 Methyltransferase domain; Region: Methyltransf_12; pfam08242 431943004885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 431943004886 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943004887 Condensation domain; Region: Condensation; pfam00668 431943004888 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943004889 Nonribosomal peptide synthase; Region: NRPS; pfam08415 431943004890 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943004891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 431943004892 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 431943004893 Condensation domain; Region: Condensation; pfam00668 431943004894 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943004895 Nonribosomal peptide synthase; Region: NRPS; pfam08415 431943004896 Methyltransferase domain; Region: Methyltransf_12; pfam08242 431943004897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943004898 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 431943004899 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 431943004900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 431943004901 Condensation domain; Region: Condensation; pfam00668 431943004902 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943004903 Nonribosomal peptide synthase; Region: NRPS; pfam08415 431943004904 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 431943004905 acyl-activating enzyme (AAE) consensus motif; other site 431943004906 AMP binding site [chemical binding]; other site 431943004907 Methyltransferase domain; Region: Methyltransf_23; pfam13489 431943004908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943004909 S-adenosylmethionine binding site [chemical binding]; other site 431943004910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 431943004911 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943004912 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943004913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943004914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943004915 Walker A/P-loop; other site 431943004916 ATP binding site [chemical binding]; other site 431943004917 Q-loop/lid; other site 431943004918 ABC transporter signature motif; other site 431943004919 Walker B; other site 431943004920 D-loop; other site 431943004921 H-loop/switch region; other site 431943004922 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943004923 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943004924 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 431943004925 Walker A/P-loop; other site 431943004926 ATP binding site [chemical binding]; other site 431943004927 Q-loop/lid; other site 431943004928 ABC transporter signature motif; other site 431943004929 Walker B; other site 431943004930 D-loop; other site 431943004931 H-loop/switch region; other site 431943004932 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 431943004933 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 431943004934 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 431943004935 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 431943004936 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 431943004937 Walker A/P-loop; other site 431943004938 ATP binding site [chemical binding]; other site 431943004939 Q-loop/lid; other site 431943004940 ABC transporter signature motif; other site 431943004941 Walker B; other site 431943004942 D-loop; other site 431943004943 H-loop/switch region; other site 431943004944 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 431943004945 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 431943004946 Walker A/P-loop; other site 431943004947 ATP binding site [chemical binding]; other site 431943004948 Q-loop/lid; other site 431943004949 ABC transporter signature motif; other site 431943004950 Walker B; other site 431943004951 D-loop; other site 431943004952 H-loop/switch region; other site 431943004953 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 431943004954 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 431943004955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943004956 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943004957 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943004958 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943004959 Walker A/P-loop; other site 431943004960 ATP binding site [chemical binding]; other site 431943004961 Q-loop/lid; other site 431943004962 ABC transporter signature motif; other site 431943004963 Walker B; other site 431943004964 D-loop; other site 431943004965 H-loop/switch region; other site 431943004966 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 431943004967 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 431943004968 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 431943004969 Condensation domain; Region: Condensation; pfam00668 431943004970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 431943004971 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 431943004972 acyl-activating enzyme (AAE) consensus motif; other site 431943004973 AMP binding site [chemical binding]; other site 431943004974 Condensation domain; Region: Condensation; pfam00668 431943004975 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 431943004976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 431943004977 classical (c) SDRs; Region: SDR_c; cd05233 431943004978 NAD(P) binding site [chemical binding]; other site 431943004979 active site 431943004980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943004981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943004982 putative substrate translocation pore; other site 431943004983 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 431943004984 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 431943004985 acyl-activating enzyme (AAE) consensus motif; other site 431943004986 putative AMP binding site [chemical binding]; other site 431943004987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943004988 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 431943004989 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 431943004990 active site 431943004991 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 431943004992 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 431943004993 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 431943004994 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 431943004995 putative NADP binding site [chemical binding]; other site 431943004996 active site 431943004997 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 431943004998 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 431943004999 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 431943005000 active site 431943005001 FMN-binding domain; Region: FMN_bind; cl01081 431943005002 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 431943005003 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943005004 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 431943005005 Uncharacterized conserved protein [Function unknown]; Region: COG2006 431943005006 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 431943005007 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 431943005008 NodB motif; other site 431943005009 active site 431943005010 catalytic site [active] 431943005011 metal binding site [ion binding]; metal-binding site 431943005012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943005013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943005014 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 431943005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943005016 putative substrate translocation pore; other site 431943005017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943005018 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 431943005019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943005020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943005021 metal binding site [ion binding]; metal-binding site 431943005022 active site 431943005023 I-site; other site 431943005024 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 431943005025 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 431943005026 oligomer interface [polypeptide binding]; other site 431943005027 metal binding site [ion binding]; metal-binding site 431943005028 metal binding site [ion binding]; metal-binding site 431943005029 putative Cl binding site [ion binding]; other site 431943005030 aspartate ring; other site 431943005031 basic sphincter; other site 431943005032 hydrophobic gate; other site 431943005033 periplasmic entrance; other site 431943005034 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 431943005035 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 431943005036 oligomer interface [polypeptide binding]; other site 431943005037 putative active site [active] 431943005038 metal binding site [ion binding]; metal-binding site 431943005039 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 431943005040 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 431943005041 active site 431943005042 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 431943005043 Membrane protein of unknown function; Region: DUF360; pfam04020 431943005044 Hemerythrin; Region: Hemerythrin; cd12107 431943005045 Fe binding site [ion binding]; other site 431943005046 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 431943005047 aspartate ammonia-lyase; Provisional; Region: PRK13353 431943005048 Aspartase; Region: Aspartase; cd01357 431943005049 active sites [active] 431943005050 tetramer interface [polypeptide binding]; other site 431943005051 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 431943005052 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 431943005053 NAD binding site [chemical binding]; other site 431943005054 homodimer interface [polypeptide binding]; other site 431943005055 active site 431943005056 substrate binding site [chemical binding]; other site 431943005057 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 431943005058 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 431943005059 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 431943005060 active site 431943005061 HIGH motif; other site 431943005062 KMSK motif region; other site 431943005063 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 431943005064 tRNA binding surface [nucleotide binding]; other site 431943005065 anticodon binding site; other site 431943005066 RNase_H superfamily; Region: RNase_H_2; pfam13482 431943005067 active site 431943005068 substrate binding site [chemical binding]; other site 431943005069 FOG: CBS domain [General function prediction only]; Region: COG0517 431943005070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 431943005071 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 431943005072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943005073 motif II; other site 431943005074 RNase_H superfamily; Region: RNase_H_2; pfam13482 431943005075 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 431943005076 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 431943005077 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 431943005078 G1 box; other site 431943005079 GTP/Mg2+ binding site [chemical binding]; other site 431943005080 G2 box; other site 431943005081 Switch I region; other site 431943005082 Switch II region; other site 431943005083 G3 box; other site 431943005084 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 431943005085 heterotetramer interface [polypeptide binding]; other site 431943005086 active site pocket [active] 431943005087 cleavage site 431943005088 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 431943005089 feedback inhibition sensing region; other site 431943005090 homohexameric interface [polypeptide binding]; other site 431943005091 nucleotide binding site [chemical binding]; other site 431943005092 N-acetyl-L-glutamate binding site [chemical binding]; other site 431943005093 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943005094 acetylornithine aminotransferase; Provisional; Region: PRK02627 431943005095 inhibitor-cofactor binding pocket; inhibition site 431943005096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005097 catalytic residue [active] 431943005098 Ion channel; Region: Ion_trans_2; pfam07885 431943005099 S-ribosylhomocysteinase; Provisional; Region: PRK02260 431943005100 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 431943005101 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 431943005102 putative ATP binding site [chemical binding]; other site 431943005103 putative substrate interface [chemical binding]; other site 431943005104 Predicted amidohydrolase [General function prediction only]; Region: COG0388 431943005105 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 431943005106 putative active site [active] 431943005107 catalytic triad [active] 431943005108 dimer interface [polypeptide binding]; other site 431943005109 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 431943005110 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 431943005111 DXD motif; other site 431943005112 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 431943005113 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 431943005114 active site 431943005115 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 431943005116 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 431943005117 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 431943005118 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 431943005119 putative active site [active] 431943005120 HI0933-like protein; Region: HI0933_like; pfam03486 431943005121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943005122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943005123 cytidylate kinase; Provisional; Region: cmk; PRK00023 431943005124 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 431943005125 CMP-binding site; other site 431943005126 The sites determining sugar specificity; other site 431943005127 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 431943005128 LytB protein; Region: LYTB; cl00507 431943005129 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 431943005130 RNA binding site [nucleotide binding]; other site 431943005131 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 431943005132 RNA binding site [nucleotide binding]; other site 431943005133 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 431943005134 RNA binding site [nucleotide binding]; other site 431943005135 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 431943005136 RNA binding site [nucleotide binding]; other site 431943005137 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 431943005138 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 431943005139 aspartate aminotransferase; Provisional; Region: PRK07568 431943005140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943005141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005142 homodimer interface [polypeptide binding]; other site 431943005143 catalytic residue [active] 431943005144 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943005145 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943005146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943005147 S-adenosylmethionine binding site [chemical binding]; other site 431943005148 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 431943005149 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 431943005150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005151 FeS/SAM binding site; other site 431943005152 TRAM domain; Region: TRAM; pfam01938 431943005153 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 431943005154 MutS domain I; Region: MutS_I; pfam01624 431943005155 MutS domain II; Region: MutS_II; pfam05188 431943005156 MutS domain III; Region: MutS_III; pfam05192 431943005157 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 431943005158 Walker A/P-loop; other site 431943005159 ATP binding site [chemical binding]; other site 431943005160 Q-loop/lid; other site 431943005161 ABC transporter signature motif; other site 431943005162 Walker B; other site 431943005163 D-loop; other site 431943005164 H-loop/switch region; other site 431943005165 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 431943005166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943005167 ATP binding site [chemical binding]; other site 431943005168 Mg2+ binding site [ion binding]; other site 431943005169 G-X-G motif; other site 431943005170 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 431943005171 ATP binding site [chemical binding]; other site 431943005172 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 431943005173 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 431943005174 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 431943005175 bacterial Hfq-like; Region: Hfq; cd01716 431943005176 hexamer interface [polypeptide binding]; other site 431943005177 Sm1 motif; other site 431943005178 RNA binding site [nucleotide binding]; other site 431943005179 Sm2 motif; other site 431943005180 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 431943005181 Aluminium resistance protein; Region: Alum_res; pfam06838 431943005182 LexA repressor; Validated; Region: PRK00215 431943005183 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 431943005184 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 431943005185 Catalytic site [active] 431943005186 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 431943005187 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943005188 active site 431943005189 DNA binding site [nucleotide binding] 431943005190 Int/Topo IB signature motif; other site 431943005191 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 431943005192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 431943005193 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 431943005194 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 431943005195 Uncharacterized conserved protein [Function unknown]; Region: COG1284 431943005196 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 431943005197 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 431943005198 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 431943005199 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 431943005200 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 431943005201 stage V sporulation protein AD; Provisional; Region: PRK12404 431943005202 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 431943005203 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 431943005204 Predicted membrane protein [Function unknown]; Region: COG2323 431943005205 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 431943005206 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 431943005207 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 431943005208 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 431943005209 active site 431943005210 nucleophile elbow; other site 431943005211 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 431943005212 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 431943005213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 431943005214 nucleotide binding site [chemical binding]; other site 431943005215 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 431943005216 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 431943005217 Ca binding site [ion binding]; other site 431943005218 active site 431943005219 catalytic site [active] 431943005220 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 431943005221 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 431943005222 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 431943005223 G1 box; other site 431943005224 GTP/Mg2+ binding site [chemical binding]; other site 431943005225 Switch I region; other site 431943005226 G2 box; other site 431943005227 G3 box; other site 431943005228 Switch II region; other site 431943005229 G4 box; other site 431943005230 G5 box; other site 431943005231 RecX family; Region: RecX; cl00936 431943005232 Nucleoside recognition; Region: Gate; pfam07670 431943005233 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 431943005234 Nucleoside recognition; Region: Gate; pfam07670 431943005235 FeoA domain; Region: FeoA; pfam04023 431943005236 FeoA domain; Region: FeoA; pfam04023 431943005237 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 431943005238 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 431943005239 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 431943005240 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 431943005241 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 431943005242 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 431943005243 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005245 non-specific DNA binding site [nucleotide binding]; other site 431943005246 salt bridge; other site 431943005247 sequence-specific DNA binding site [nucleotide binding]; other site 431943005248 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 431943005249 purine nucleoside phosphorylase; Provisional; Region: PRK08202 431943005250 homoserine O-succinyltransferase; Provisional; Region: PRK05368 431943005251 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 431943005252 proposed active site lysine [active] 431943005253 conserved cys residue [active] 431943005254 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943005255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943005256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943005257 DNA binding residues [nucleotide binding] 431943005258 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 431943005259 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 431943005260 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 431943005261 putative catalytic cysteine [active] 431943005262 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 431943005263 putative active site [active] 431943005264 metal binding site [ion binding]; metal-binding site 431943005265 Penicillinase repressor; Region: Pencillinase_R; pfam03965 431943005266 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943005267 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 431943005268 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 431943005269 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 431943005270 putative valine binding site [chemical binding]; other site 431943005271 dimer interface [polypeptide binding]; other site 431943005272 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 431943005273 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 431943005274 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 431943005275 PYR/PP interface [polypeptide binding]; other site 431943005276 dimer interface [polypeptide binding]; other site 431943005277 TPP binding site [chemical binding]; other site 431943005278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 431943005279 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 431943005280 TPP-binding site [chemical binding]; other site 431943005281 dimer interface [polypeptide binding]; other site 431943005282 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 431943005283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943005284 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 431943005285 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 431943005286 active site 431943005287 dimer interface [polypeptide binding]; other site 431943005288 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 431943005289 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 431943005290 active site 431943005291 FMN binding site [chemical binding]; other site 431943005292 substrate binding site [chemical binding]; other site 431943005293 3Fe-4S cluster binding site [ion binding]; other site 431943005294 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 431943005295 domain interface; other site 431943005296 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 431943005297 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 431943005298 tetramerization interface [polypeptide binding]; other site 431943005299 active site 431943005300 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 431943005301 active site 431943005302 catalytic triad [active] 431943005303 oxyanion hole [active] 431943005304 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 431943005305 active site 431943005306 multimer interface [polypeptide binding]; other site 431943005307 Predicted membrane protein [Function unknown]; Region: COG1511 431943005308 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 431943005309 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 431943005310 Predicted membrane protein [Function unknown]; Region: COG1511 431943005311 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 431943005312 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 431943005313 Homoserine O-succinyltransferase; Region: HTS; pfam04204 431943005314 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 431943005315 proposed active site lysine [active] 431943005316 conserved cys residue [active] 431943005317 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 431943005318 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943005319 homodimer interface [polypeptide binding]; other site 431943005320 substrate-cofactor binding pocket; other site 431943005321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005322 catalytic residue [active] 431943005323 S-adenosylmethionine synthetase; Validated; Region: PRK05250 431943005324 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 431943005325 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 431943005326 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 431943005327 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 431943005328 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 431943005329 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 431943005330 thiamine phosphate binding site [chemical binding]; other site 431943005331 active site 431943005332 pyrophosphate binding site [ion binding]; other site 431943005333 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 431943005334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005335 FeS/SAM binding site; other site 431943005336 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 431943005337 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 431943005338 ThiS interaction site; other site 431943005339 putative active site [active] 431943005340 tetramer interface [polypeptide binding]; other site 431943005341 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 431943005342 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 431943005343 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 431943005344 ATP binding site [chemical binding]; other site 431943005345 substrate interface [chemical binding]; other site 431943005346 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 431943005347 thiS-thiF/thiG interaction site; other site 431943005348 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943005349 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943005350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943005351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943005352 dimer interface [polypeptide binding]; other site 431943005353 phosphorylation site [posttranslational modification] 431943005354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943005355 ATP binding site [chemical binding]; other site 431943005356 G-X-G motif; other site 431943005357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943005358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943005359 active site 431943005360 phosphorylation site [posttranslational modification] 431943005361 intermolecular recognition site; other site 431943005362 dimerization interface [polypeptide binding]; other site 431943005363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943005364 DNA binding site [nucleotide binding] 431943005365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943005366 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943005367 FtsX-like permease family; Region: FtsX; pfam02687 431943005368 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943005369 FtsX-like permease family; Region: FtsX; pfam02687 431943005370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943005371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943005372 Walker A/P-loop; other site 431943005373 ATP binding site [chemical binding]; other site 431943005374 Q-loop/lid; other site 431943005375 ABC transporter signature motif; other site 431943005376 Walker B; other site 431943005377 D-loop; other site 431943005378 H-loop/switch region; other site 431943005379 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005381 non-specific DNA binding site [nucleotide binding]; other site 431943005382 salt bridge; other site 431943005383 sequence-specific DNA binding site [nucleotide binding]; other site 431943005384 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 431943005385 Catalytic site [active] 431943005386 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 431943005387 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 431943005388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943005389 putative substrate translocation pore; other site 431943005390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943005391 MarR family; Region: MarR_2; pfam12802 431943005392 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 431943005393 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 431943005394 GIY-YIG motif/motif A; other site 431943005395 active site 431943005396 catalytic site [active] 431943005397 putative DNA binding site [nucleotide binding]; other site 431943005398 metal binding site [ion binding]; metal-binding site 431943005399 UvrB/uvrC motif; Region: UVR; pfam02151 431943005400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 431943005401 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 431943005402 phosphoenolpyruvate synthase; Validated; Region: PRK06241 431943005403 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943005404 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 431943005405 ArsC family; Region: ArsC; pfam03960 431943005406 catalytic residue [active] 431943005407 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 431943005408 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943005409 FtsX-like permease family; Region: FtsX; pfam02687 431943005410 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 431943005411 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943005412 FtsX-like permease family; Region: FtsX; pfam02687 431943005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 431943005414 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 431943005415 Probable transposase; Region: OrfB_IS605; pfam01385 431943005416 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 431943005417 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 431943005418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943005419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943005420 Walker A/P-loop; other site 431943005421 ATP binding site [chemical binding]; other site 431943005422 Q-loop/lid; other site 431943005423 ABC transporter signature motif; other site 431943005424 Walker B; other site 431943005425 D-loop; other site 431943005426 H-loop/switch region; other site 431943005427 Tubulin like; Region: Tubulin_2; pfam13809 431943005428 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 431943005429 metal ion-dependent adhesion site (MIDAS); other site 431943005430 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 431943005431 Coat F domain; Region: Coat_F; pfam07875 431943005432 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943005433 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943005434 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 431943005435 pentamer interface [polypeptide binding]; other site 431943005436 dodecaamer interface [polypeptide binding]; other site 431943005437 VanZ like family; Region: VanZ; pfam04892 431943005438 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 431943005439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943005440 DNA binding residues [nucleotide binding] 431943005441 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 431943005442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943005443 dimerization interface [polypeptide binding]; other site 431943005444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943005445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943005446 dimer interface [polypeptide binding]; other site 431943005447 phosphorylation site [posttranslational modification] 431943005448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943005449 ATP binding site [chemical binding]; other site 431943005450 Mg2+ binding site [ion binding]; other site 431943005451 G-X-G motif; other site 431943005452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943005453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943005454 active site 431943005455 phosphorylation site [posttranslational modification] 431943005456 intermolecular recognition site; other site 431943005457 dimerization interface [polypeptide binding]; other site 431943005458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943005459 DNA binding site [nucleotide binding] 431943005460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 431943005461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943005462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943005463 Walker A/P-loop; other site 431943005464 ATP binding site [chemical binding]; other site 431943005465 Q-loop/lid; other site 431943005466 ABC transporter signature motif; other site 431943005467 Walker B; other site 431943005468 D-loop; other site 431943005469 H-loop/switch region; other site 431943005470 aminotransferase; Validated; Region: PRK08175 431943005471 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 431943005472 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 431943005473 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 431943005474 catalytic core [active] 431943005475 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 431943005476 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943005477 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943005478 active site 431943005479 FMN binding site [chemical binding]; other site 431943005480 substrate binding site [chemical binding]; other site 431943005481 putative catalytic residue [active] 431943005482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943005483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943005484 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943005485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943005486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 431943005487 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 431943005488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943005489 Walker A/P-loop; other site 431943005490 ATP binding site [chemical binding]; other site 431943005491 Q-loop/lid; other site 431943005492 ABC transporter signature motif; other site 431943005493 Walker B; other site 431943005494 D-loop; other site 431943005495 H-loop/switch region; other site 431943005496 ABC transporter; Region: ABC_tran_2; pfam12848 431943005497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943005498 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 431943005499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 431943005500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943005501 DNA-binding site [nucleotide binding]; DNA binding site 431943005502 FCD domain; Region: FCD; pfam07729 431943005503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943005504 dimer interface [polypeptide binding]; other site 431943005505 putative CheW interface [polypeptide binding]; other site 431943005506 biotin synthase; Region: bioB; TIGR00433 431943005507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005508 FeS/SAM binding site; other site 431943005509 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 431943005510 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 431943005511 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943005512 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 431943005513 active site 431943005514 metal binding site [ion binding]; metal-binding site 431943005515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 431943005516 active site 431943005517 metal binding site [ion binding]; metal-binding site 431943005518 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943005519 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943005520 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943005521 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 431943005522 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 431943005523 Spore germination protein; Region: Spore_permease; cl17796 431943005524 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943005525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005526 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 431943005527 FeS/SAM binding site; other site 431943005528 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 431943005529 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 431943005530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 431943005531 ABC-ATPase subunit interface; other site 431943005532 dimer interface [polypeptide binding]; other site 431943005533 putative PBP binding regions; other site 431943005534 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 431943005535 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 431943005536 Walker A/P-loop; other site 431943005537 ATP binding site [chemical binding]; other site 431943005538 Q-loop/lid; other site 431943005539 ABC transporter signature motif; other site 431943005540 Walker B; other site 431943005541 D-loop; other site 431943005542 H-loop/switch region; other site 431943005543 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943005544 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 431943005545 putative ligand binding residues [chemical binding]; other site 431943005546 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943005547 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 431943005548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943005549 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 431943005550 motif II; other site 431943005551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943005552 dimerization interface [polypeptide binding]; other site 431943005553 putative DNA binding site [nucleotide binding]; other site 431943005554 putative Zn2+ binding site [ion binding]; other site 431943005555 Predicted permeases [General function prediction only]; Region: COG0701 431943005556 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 431943005557 Transposase; Region: HTH_Tnp_1; cl17663 431943005558 HTH-like domain; Region: HTH_21; pfam13276 431943005559 Integrase core domain; Region: rve; pfam00665 431943005560 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943005561 Integrase core domain; Region: rve_3; pfam13683 431943005562 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 431943005563 Low molecular weight phosphatase family; Region: LMWPc; cd00115 431943005564 active site 431943005565 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 431943005566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943005567 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 431943005568 NodB motif; other site 431943005569 active site 431943005570 catalytic site [active] 431943005571 Zn binding site [ion binding]; other site 431943005572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943005573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943005574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943005575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943005576 putative substrate translocation pore; other site 431943005577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943005578 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 431943005579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 431943005580 Transposase; Region: DDE_Tnp_ISL3; pfam01610 431943005581 Transposase; Region: DDE_Tnp_ISL3; pfam01610 431943005582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 431943005583 HTH-like domain; Region: HTH_21; pfam13276 431943005584 Integrase core domain; Region: rve; pfam00665 431943005585 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943005586 Integrase core domain; Region: rve_3; pfam13683 431943005587 Transposase; Region: HTH_Tnp_1; cl17663 431943005588 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 431943005589 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 431943005590 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 431943005591 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 431943005592 putative NADP binding site [chemical binding]; other site 431943005593 active site 431943005594 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943005595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 431943005596 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 431943005597 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 431943005598 active site 431943005599 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 431943005600 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 431943005601 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 431943005602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 431943005603 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 431943005604 active site 431943005605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943005606 Condensation domain; Region: Condensation; pfam00668 431943005607 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943005608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 431943005609 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 431943005610 acyl-activating enzyme (AAE) consensus motif; other site 431943005611 AMP binding site [chemical binding]; other site 431943005612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943005613 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 431943005614 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 431943005615 acyl-activating enzyme (AAE) consensus motif; other site 431943005616 putative AMP binding site [chemical binding]; other site 431943005617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943005618 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 431943005619 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 431943005620 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 431943005621 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 431943005622 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 431943005623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943005624 active site 431943005625 DNA binding site [nucleotide binding] 431943005626 Int/Topo IB signature motif; other site 431943005627 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 431943005628 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943005629 active site 431943005630 DNA binding site [nucleotide binding] 431943005631 Int/Topo IB signature motif; other site 431943005632 seryl-tRNA synthetase; Provisional; Region: PRK05431 431943005633 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 431943005634 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943005635 putative ligand binding residues [chemical binding]; other site 431943005636 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943005637 PBP superfamily domain; Region: PBP_like; pfam12727 431943005638 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943005639 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943005640 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 431943005641 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943005642 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943005643 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943005644 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 431943005645 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 431943005646 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 431943005647 nitrogenase iron protein; Region: nifH; TIGR01287 431943005648 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 431943005649 Nucleotide-binding sites [chemical binding]; other site 431943005650 Walker A motif; other site 431943005651 Switch I region of nucleotide binding site; other site 431943005652 Fe4S4 binding sites [ion binding]; other site 431943005653 Switch II region of nucleotide binding site; other site 431943005654 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 431943005655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005656 FeS/SAM binding site; other site 431943005657 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 431943005658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005659 non-specific DNA binding site [nucleotide binding]; other site 431943005660 salt bridge; other site 431943005661 sequence-specific DNA binding site [nucleotide binding]; other site 431943005662 Domain of unknown function (DUF955); Region: DUF955; cl01076 431943005663 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 431943005664 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943005665 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 431943005666 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943005667 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 431943005668 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 431943005669 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 431943005670 active site 431943005671 catalytic residues [active] 431943005672 metal binding site [ion binding]; metal-binding site 431943005673 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 431943005674 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 431943005675 metal binding site [ion binding]; metal-binding site 431943005676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943005677 Coenzyme A binding pocket [chemical binding]; other site 431943005678 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 431943005679 reactive center loop; other site 431943005680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943005681 Zn2+ binding site [ion binding]; other site 431943005682 Mg2+ binding site [ion binding]; other site 431943005683 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 431943005684 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 431943005685 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 431943005686 FAD binding site [chemical binding]; other site 431943005687 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 431943005688 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 431943005689 THF binding site; other site 431943005690 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 431943005691 substrate binding site [chemical binding]; other site 431943005692 THF binding site; other site 431943005693 zinc-binding site [ion binding]; other site 431943005694 HD domain; Region: HD_4; pfam13328 431943005695 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 431943005696 Part of AAA domain; Region: AAA_19; pfam13245 431943005697 Family description; Region: UvrD_C_2; pfam13538 431943005698 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 431943005699 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 431943005700 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 431943005701 Catalytic site [active] 431943005702 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 431943005703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943005704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943005705 DNA binding residues [nucleotide binding] 431943005706 Putative zinc-finger; Region: zf-HC2; pfam13490 431943005707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 431943005708 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 431943005709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943005710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943005711 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 431943005712 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 431943005713 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 431943005714 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 431943005715 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 431943005716 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 431943005717 tetramer interface [polypeptide binding]; other site 431943005718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005719 catalytic residue [active] 431943005720 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 431943005721 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 431943005722 tetramer interface [polypeptide binding]; other site 431943005723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005724 catalytic residue [active] 431943005725 glycine cleavage system protein H; Provisional; Region: PRK13380 431943005726 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 431943005727 lipoyl attachment site [posttranslational modification]; other site 431943005728 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 431943005729 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 431943005730 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943005731 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 431943005732 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 431943005733 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 431943005734 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 431943005735 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 431943005736 active site 431943005737 Substrate binding site; other site 431943005738 Mg++ binding site; other site 431943005739 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 431943005740 putative trimer interface [polypeptide binding]; other site 431943005741 putative CoA binding site [chemical binding]; other site 431943005742 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 431943005743 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 431943005744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943005745 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 431943005746 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943005747 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 431943005748 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 431943005749 FAD binding domain; Region: FAD_binding_4; pfam01565 431943005750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943005751 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943005752 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 431943005753 Walker A/P-loop; other site 431943005754 ATP binding site [chemical binding]; other site 431943005755 Q-loop/lid; other site 431943005756 ABC transporter signature motif; other site 431943005757 Walker B; other site 431943005758 D-loop; other site 431943005759 H-loop/switch region; other site 431943005760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943005761 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 431943005762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943005763 Walker A/P-loop; other site 431943005764 ATP binding site [chemical binding]; other site 431943005765 Q-loop/lid; other site 431943005766 ABC transporter signature motif; other site 431943005767 Walker B; other site 431943005768 D-loop; other site 431943005769 H-loop/switch region; other site 431943005770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 431943005771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943005772 putative DNA binding site [nucleotide binding]; other site 431943005773 putative Zn2+ binding site [ion binding]; other site 431943005774 LysE type translocator; Region: LysE; cl00565 431943005775 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 431943005776 Uncharacterized conserved protein [Function unknown]; Region: COG1284 431943005777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 431943005778 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 431943005779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943005780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943005781 metal binding site [ion binding]; metal-binding site 431943005782 active site 431943005783 I-site; other site 431943005784 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 431943005785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943005786 motif II; other site 431943005787 Uncharacterized conserved protein [Function unknown]; Region: COG1359 431943005788 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 431943005789 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 431943005790 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943005791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943005792 dimer interface [polypeptide binding]; other site 431943005793 putative CheW interface [polypeptide binding]; other site 431943005794 Cache domain; Region: Cache_1; pfam02743 431943005795 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 431943005796 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 431943005797 CysD dimerization site [polypeptide binding]; other site 431943005798 G1 box; other site 431943005799 putative GEF interaction site [polypeptide binding]; other site 431943005800 GTP/Mg2+ binding site [chemical binding]; other site 431943005801 Switch I region; other site 431943005802 G2 box; other site 431943005803 G3 box; other site 431943005804 Switch II region; other site 431943005805 G4 box; other site 431943005806 G5 box; other site 431943005807 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 431943005808 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 431943005809 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 431943005810 ligand-binding site [chemical binding]; other site 431943005811 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 431943005812 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 431943005813 Active Sites [active] 431943005814 Ferredoxin [Energy production and conversion]; Region: COG1146 431943005815 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 431943005816 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 431943005817 L-aspartate oxidase; Provisional; Region: PRK06175 431943005818 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 431943005819 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 431943005820 AAA domain; Region: AAA_18; pfam13238 431943005821 ligand-binding site [chemical binding]; other site 431943005822 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 431943005823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943005824 Walker A/P-loop; other site 431943005825 ATP binding site [chemical binding]; other site 431943005826 Q-loop/lid; other site 431943005827 ABC transporter signature motif; other site 431943005828 Walker B; other site 431943005829 D-loop; other site 431943005830 H-loop/switch region; other site 431943005831 TOBE domain; Region: TOBE_2; pfam08402 431943005832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943005833 dimer interface [polypeptide binding]; other site 431943005834 conserved gate region; other site 431943005835 putative PBP binding loops; other site 431943005836 ABC-ATPase subunit interface; other site 431943005837 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 431943005838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943005839 dimer interface [polypeptide binding]; other site 431943005840 conserved gate region; other site 431943005841 putative PBP binding loops; other site 431943005842 ABC-ATPase subunit interface; other site 431943005843 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 431943005844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943005845 substrate binding pocket [chemical binding]; other site 431943005846 membrane-bound complex binding site; other site 431943005847 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 431943005848 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 431943005849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 431943005850 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 431943005851 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 431943005852 ATP binding site [chemical binding]; other site 431943005853 substrate interface [chemical binding]; other site 431943005854 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 431943005855 MPN+ (JAMM) motif; other site 431943005856 Zinc-binding site [ion binding]; other site 431943005857 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 431943005858 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 431943005859 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 431943005860 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 431943005861 CPxP motif; other site 431943005862 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 431943005863 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943005864 homodimer interface [polypeptide binding]; other site 431943005865 substrate-cofactor binding pocket; other site 431943005866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943005867 catalytic residue [active] 431943005868 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 431943005869 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 431943005870 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 431943005871 Catalytic site [active] 431943005872 Stage III sporulation protein D; Region: SpoIIID; pfam12116 431943005873 hypothetical protein; Provisional; Region: PRK05802 431943005874 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 431943005875 FAD binding pocket [chemical binding]; other site 431943005876 FAD binding motif [chemical binding]; other site 431943005877 phosphate binding motif [ion binding]; other site 431943005878 beta-alpha-beta structure motif; other site 431943005879 NAD binding pocket [chemical binding]; other site 431943005880 Iron coordination center [ion binding]; other site 431943005881 Glucose inhibited division protein A; Region: GIDA; pfam01134 431943005882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 431943005883 non-specific DNA binding site [nucleotide binding]; other site 431943005884 salt bridge; other site 431943005885 sequence-specific DNA binding site [nucleotide binding]; other site 431943005886 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 431943005887 DNA-binding site [nucleotide binding]; DNA binding site 431943005888 RNA-binding motif; other site 431943005889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005891 non-specific DNA binding site [nucleotide binding]; other site 431943005892 salt bridge; other site 431943005893 sequence-specific DNA binding site [nucleotide binding]; other site 431943005894 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 431943005895 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 431943005896 amidase catalytic site [active] 431943005897 Zn binding residues [ion binding]; other site 431943005898 substrate binding site [chemical binding]; other site 431943005899 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943005900 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 431943005901 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 431943005902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943005903 FeS/SAM binding site; other site 431943005904 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 431943005905 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 431943005906 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 431943005907 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 431943005908 Baseplate J-like protein; Region: Baseplate_J; pfam04865 431943005909 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 431943005910 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943005911 tape measure domain; Region: tape_meas_nterm; TIGR02675 431943005912 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 431943005913 N-acetyl-D-glucosamine binding site [chemical binding]; other site 431943005914 catalytic residue [active] 431943005915 BRO family, N-terminal domain; Region: Bro-N; smart01040 431943005916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005917 non-specific DNA binding site [nucleotide binding]; other site 431943005918 salt bridge; other site 431943005919 sequence-specific DNA binding site [nucleotide binding]; other site 431943005920 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005922 non-specific DNA binding site [nucleotide binding]; other site 431943005923 salt bridge; other site 431943005924 sequence-specific DNA binding site [nucleotide binding]; other site 431943005925 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 431943005926 Phage XkdN-like protein; Region: XkdN; pfam08890 431943005927 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 431943005928 YcfA-like protein; Region: YcfA; pfam07927 431943005929 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 431943005930 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 431943005931 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 431943005932 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 431943005933 Terminase-like family; Region: Terminase_6; pfam03237 431943005934 Phage terminase large subunit; Region: Terminase_3; cl12054 431943005935 Uncharacterized conserved protein [Function unknown]; Region: COG5484 431943005936 Phage terminase small subunit; Region: Phage_terminase; pfam10668 431943005937 NACHT domain; Region: NACHT; pfam05729 431943005938 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 431943005939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 431943005940 DNA binding residues [nucleotide binding] 431943005941 dimerization interface [polypeptide binding]; other site 431943005942 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 431943005943 HSP70 interaction site [polypeptide binding]; other site 431943005944 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 431943005945 homodimer interface [polypeptide binding]; other site 431943005946 metal binding site [ion binding]; metal-binding site 431943005947 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 431943005948 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 431943005949 Double zinc ribbon; Region: DZR; pfam12773 431943005950 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943005951 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 431943005952 replicative DNA helicase; Region: DnaB; TIGR00665 431943005953 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 431943005954 Walker A motif; other site 431943005955 ATP binding site [chemical binding]; other site 431943005956 Walker B motif; other site 431943005957 DNA binding loops [nucleotide binding] 431943005958 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 431943005959 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 431943005960 RecT family; Region: RecT; cl04285 431943005961 YopX protein; Region: YopX; pfam09643 431943005962 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 431943005963 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 431943005964 DNA binding residues [nucleotide binding] 431943005965 Prophage antirepressor [Transcription]; Region: COG3617 431943005966 BRO family, N-terminal domain; Region: Bro-N; smart01040 431943005967 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 431943005968 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005970 non-specific DNA binding site [nucleotide binding]; other site 431943005971 salt bridge; other site 431943005972 sequence-specific DNA binding site [nucleotide binding]; other site 431943005973 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005975 non-specific DNA binding site [nucleotide binding]; other site 431943005976 salt bridge; other site 431943005977 sequence-specific DNA binding site [nucleotide binding]; other site 431943005978 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943005979 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 431943005980 catalytic residues [active] 431943005981 catalytic nucleophile [active] 431943005982 Presynaptic Site I dimer interface [polypeptide binding]; other site 431943005983 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 431943005984 Synaptic Flat tetramer interface [polypeptide binding]; other site 431943005985 Synaptic Site I dimer interface [polypeptide binding]; other site 431943005986 DNA binding site [nucleotide binding] 431943005987 Recombinase; Region: Recombinase; pfam07508 431943005988 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943005989 Glucose inhibited division protein A; Region: GIDA; pfam01134 431943005990 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005992 non-specific DNA binding site [nucleotide binding]; other site 431943005993 salt bridge; other site 431943005994 sequence-specific DNA binding site [nucleotide binding]; other site 431943005995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943005996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943005997 non-specific DNA binding site [nucleotide binding]; other site 431943005998 salt bridge; other site 431943005999 sequence-specific DNA binding site [nucleotide binding]; other site 431943006000 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 431943006001 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 431943006002 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 431943006003 amidase catalytic site [active] 431943006004 Zn binding residues [ion binding]; other site 431943006005 substrate binding site [chemical binding]; other site 431943006006 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943006007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006008 non-specific DNA binding site [nucleotide binding]; other site 431943006009 salt bridge; other site 431943006010 sequence-specific DNA binding site [nucleotide binding]; other site 431943006011 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 431943006012 BNR repeat-like domain; Region: BNR_2; pfam13088 431943006013 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 431943006014 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 431943006015 Baseplate J-like protein; Region: Baseplate_J; pfam04865 431943006016 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 431943006017 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943006018 tape measure domain; Region: tape_meas_nterm; TIGR02675 431943006019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 431943006020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 431943006021 catalytic residue [active] 431943006022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943006023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006024 non-specific DNA binding site [nucleotide binding]; other site 431943006025 salt bridge; other site 431943006026 sequence-specific DNA binding site [nucleotide binding]; other site 431943006027 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 431943006028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943006029 TPR motif; other site 431943006030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943006031 binding surface 431943006032 Phage XkdN-like protein; Region: XkdN; pfam08890 431943006033 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 431943006034 YcfA-like protein; Region: YcfA; pfam07927 431943006035 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 431943006036 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 431943006037 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 431943006038 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 431943006039 Terminase-like family; Region: Terminase_6; pfam03237 431943006040 Phage terminase large subunit; Region: Terminase_3; cl12054 431943006041 Uncharacterized conserved protein [Function unknown]; Region: COG5484 431943006042 Phage terminase small subunit; Region: Phage_terminase; pfam10668 431943006043 NACHT domain; Region: NACHT; pfam05729 431943006044 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 431943006045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 431943006046 DNA binding residues [nucleotide binding] 431943006047 dimerization interface [polypeptide binding]; other site 431943006048 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 431943006049 HSP70 interaction site [polypeptide binding]; other site 431943006050 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 431943006051 homodimer interface [polypeptide binding]; other site 431943006052 metal binding site [ion binding]; metal-binding site 431943006053 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 431943006054 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 431943006055 Double zinc ribbon; Region: DZR; pfam12773 431943006056 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943006057 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 431943006058 replicative DNA helicase; Region: DnaB; TIGR00665 431943006059 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 431943006060 Walker A motif; other site 431943006061 ATP binding site [chemical binding]; other site 431943006062 Walker B motif; other site 431943006063 DNA binding loops [nucleotide binding] 431943006064 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 431943006065 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 431943006066 RecT family; Region: RecT; cl04285 431943006067 YopX protein; Region: YopX; pfam09643 431943006068 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 431943006069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 431943006070 DNA binding residues [nucleotide binding] 431943006071 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943006072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006073 non-specific DNA binding site [nucleotide binding]; other site 431943006074 salt bridge; other site 431943006075 sequence-specific DNA binding site [nucleotide binding]; other site 431943006076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006077 sequence-specific DNA binding site [nucleotide binding]; other site 431943006078 salt bridge; other site 431943006079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943006080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006081 non-specific DNA binding site [nucleotide binding]; other site 431943006082 salt bridge; other site 431943006083 sequence-specific DNA binding site [nucleotide binding]; other site 431943006084 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 431943006085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 431943006086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006087 non-specific DNA binding site [nucleotide binding]; other site 431943006088 salt bridge; other site 431943006089 sequence-specific DNA binding site [nucleotide binding]; other site 431943006090 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943006091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006092 non-specific DNA binding site [nucleotide binding]; other site 431943006093 salt bridge; other site 431943006094 sequence-specific DNA binding site [nucleotide binding]; other site 431943006095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943006096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006097 non-specific DNA binding site [nucleotide binding]; other site 431943006098 salt bridge; other site 431943006099 sequence-specific DNA binding site [nucleotide binding]; other site 431943006100 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 431943006101 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 431943006102 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 431943006103 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943006104 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 431943006105 catalytic residues [active] 431943006106 catalytic nucleophile [active] 431943006107 Presynaptic Site I dimer interface [polypeptide binding]; other site 431943006108 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 431943006109 Synaptic Flat tetramer interface [polypeptide binding]; other site 431943006110 Synaptic Site I dimer interface [polypeptide binding]; other site 431943006111 DNA binding site [nucleotide binding] 431943006112 Recombinase; Region: Recombinase; pfam07508 431943006113 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943006114 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 431943006115 Predicted amidohydrolase [General function prediction only]; Region: COG0388 431943006116 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 431943006117 putative active site [active] 431943006118 catalytic triad [active] 431943006119 putative dimer interface [polypeptide binding]; other site 431943006120 EamA-like transporter family; Region: EamA; pfam00892 431943006121 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 431943006122 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 431943006123 nucleophilic elbow; other site 431943006124 catalytic triad; other site 431943006125 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 431943006126 LrgA family; Region: LrgA; cl00608 431943006127 Rubrerythrin [Energy production and conversion]; Region: COG1592 431943006128 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 431943006129 binuclear metal center [ion binding]; other site 431943006130 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 431943006131 iron binding site [ion binding]; other site 431943006132 Uncharacterized conserved protein [Function unknown]; Region: COG1432 431943006133 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 431943006134 putative metal binding site [ion binding]; other site 431943006135 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 431943006136 Predicted membrane protein [Function unknown]; Region: COG2246 431943006137 GtrA-like protein; Region: GtrA; pfam04138 431943006138 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 431943006139 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 431943006140 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 431943006141 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 431943006142 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943006143 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943006144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006145 dimer interface [polypeptide binding]; other site 431943006146 putative CheW interface [polypeptide binding]; other site 431943006147 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 431943006148 Uncharacterized conserved protein [Function unknown]; Region: COG1284 431943006149 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 431943006150 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 431943006151 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943006152 Sensory domain found in PocR; Region: PocR; pfam10114 431943006153 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943006154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006155 dimer interface [polypeptide binding]; other site 431943006156 putative CheW interface [polypeptide binding]; other site 431943006157 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 431943006158 Na binding site [ion binding]; other site 431943006159 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943006160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006161 dimer interface [polypeptide binding]; other site 431943006162 putative CheW interface [polypeptide binding]; other site 431943006163 Uncharacterized conserved protein [Function unknown]; Region: COG3287 431943006164 FIST N domain; Region: FIST; smart00897 431943006165 FIST C domain; Region: FIST_C; pfam10442 431943006166 FlxA-like protein; Region: FlxA; pfam14282 431943006167 Putative motility protein; Region: YjfB_motility; pfam14070 431943006168 Protein of unknown function DUF86; Region: DUF86; pfam01934 431943006169 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943006170 active site 431943006171 NTP binding site [chemical binding]; other site 431943006172 metal binding triad [ion binding]; metal-binding site 431943006173 antibiotic binding site [chemical binding]; other site 431943006174 OPT oligopeptide transporter protein; Region: OPT; cl14607 431943006175 Predicted permeases [General function prediction only]; Region: COG0679 431943006176 hypothetical protein; Provisional; Region: PRK07475 431943006177 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 431943006178 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 431943006179 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 431943006180 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 431943006181 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 431943006182 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 431943006183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 431943006184 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 431943006185 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 431943006186 catalytic loop [active] 431943006187 iron binding site [ion binding]; other site 431943006188 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 431943006189 homotrimer interaction site [polypeptide binding]; other site 431943006190 putative active site [active] 431943006191 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 431943006192 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 431943006193 ligand binding site [chemical binding]; other site 431943006194 NAD binding site [chemical binding]; other site 431943006195 catalytic site [active] 431943006196 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 431943006197 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943006198 inhibitor-cofactor binding pocket; inhibition site 431943006199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006200 catalytic residue [active] 431943006201 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943006202 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 431943006203 active site 431943006204 metal binding site [ion binding]; metal-binding site 431943006205 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 431943006206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943006207 dimer interface [polypeptide binding]; other site 431943006208 conserved gate region; other site 431943006209 putative PBP binding loops; other site 431943006210 ABC-ATPase subunit interface; other site 431943006211 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 431943006212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943006213 dimer interface [polypeptide binding]; other site 431943006214 conserved gate region; other site 431943006215 putative PBP binding loops; other site 431943006216 ABC-ATPase subunit interface; other site 431943006217 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943006218 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 431943006219 substrate binding pocket [chemical binding]; other site 431943006220 membrane-bound complex binding site; other site 431943006221 hinge residues; other site 431943006222 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 431943006223 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 431943006224 Walker A/P-loop; other site 431943006225 ATP binding site [chemical binding]; other site 431943006226 Q-loop/lid; other site 431943006227 ABC transporter signature motif; other site 431943006228 Walker B; other site 431943006229 D-loop; other site 431943006230 H-loop/switch region; other site 431943006231 Transcriptional regulators [Transcription]; Region: FadR; COG2186 431943006232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943006233 DNA-binding site [nucleotide binding]; DNA binding site 431943006234 FCD domain; Region: FCD; pfam07729 431943006235 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 431943006236 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 431943006237 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 431943006238 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 431943006239 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943006240 active site 431943006241 NTP binding site [chemical binding]; other site 431943006242 metal binding triad [ion binding]; metal-binding site 431943006243 antibiotic binding site [chemical binding]; other site 431943006244 Protein of unknown function DUF86; Region: DUF86; cl01031 431943006245 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943006246 active site 431943006247 NTP binding site [chemical binding]; other site 431943006248 metal binding triad [ion binding]; metal-binding site 431943006249 antibiotic binding site [chemical binding]; other site 431943006250 CopC domain; Region: CopC; cl01012 431943006251 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943006252 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 431943006253 Leucine-rich repeats; other site 431943006254 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943006255 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 431943006256 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 431943006257 Transposase, Mutator family; Region: Transposase_mut; pfam00872 431943006258 MULE transposase domain; Region: MULE; pfam10551 431943006259 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 431943006260 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 431943006261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 431943006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943006263 NAD(P) binding site [chemical binding]; other site 431943006264 active site 431943006265 Transposase, Mutator family; Region: Transposase_mut; pfam00872 431943006266 Transposase, Mutator family; Region: Transposase_mut; pfam00872 431943006267 MULE transposase domain; Region: MULE; pfam10551 431943006268 Putative motility protein; Region: YjfB_motility; pfam14070 431943006269 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 431943006270 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 431943006271 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 431943006272 NAD(P) binding site [chemical binding]; other site 431943006273 homodimer interface [polypeptide binding]; other site 431943006274 substrate binding site [chemical binding]; other site 431943006275 active site 431943006276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943006277 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 431943006278 NAD(P) binding site [chemical binding]; other site 431943006279 active site 431943006280 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 431943006281 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 431943006282 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 431943006283 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 431943006284 putative active site [active] 431943006285 catalytic site [active] 431943006286 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 431943006287 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 431943006288 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 431943006289 classical (c) SDRs; Region: SDR_c; cd05233 431943006290 NAD(P) binding site [chemical binding]; other site 431943006291 active site 431943006292 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 431943006293 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 431943006294 PYR/PP interface [polypeptide binding]; other site 431943006295 dimer interface [polypeptide binding]; other site 431943006296 TPP binding site [chemical binding]; other site 431943006297 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 431943006298 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 431943006299 TPP-binding site [chemical binding]; other site 431943006300 dimer interface [polypeptide binding]; other site 431943006301 Radical SAM superfamily; Region: Radical_SAM; pfam04055 431943006302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 431943006303 FeS/SAM binding site; other site 431943006304 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 431943006305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 431943006306 active site 431943006307 Methyltransferase domain; Region: Methyltransf_23; pfam13489 431943006308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943006309 S-adenosylmethionine binding site [chemical binding]; other site 431943006310 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943006311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943006312 S-adenosylmethionine binding site [chemical binding]; other site 431943006313 Methyltransferase domain; Region: Methyltransf_23; pfam13489 431943006314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943006315 S-adenosylmethionine binding site [chemical binding]; other site 431943006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 431943006317 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 431943006318 ligand binding site; other site 431943006319 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 431943006320 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 431943006321 NeuB family; Region: NeuB; pfam03102 431943006322 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 431943006323 NeuB binding interface [polypeptide binding]; other site 431943006324 putative substrate binding site [chemical binding]; other site 431943006325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 431943006326 flagellin; Provisional; Region: PRK12804 431943006327 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 431943006328 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 431943006329 Flagellar protein FliT; Region: FliT; pfam05400 431943006330 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 431943006331 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 431943006332 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 431943006333 FlaG protein; Region: FlaG; pfam03646 431943006334 Global regulator protein family; Region: CsrA; pfam02599 431943006335 flagellar assembly protein FliW; Provisional; Region: PRK13285 431943006336 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 431943006337 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 431943006338 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 431943006339 four helix bundle protein; Region: TIGR02436 431943006340 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 431943006341 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 431943006342 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 431943006343 FlgN protein; Region: FlgN; pfam05130 431943006344 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 431943006345 flagellar motor switch protein; Validated; Region: PRK08119 431943006346 CheC-like family; Region: CheC; pfam04509 431943006347 CheC-like family; Region: CheC; pfam04509 431943006348 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 431943006349 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 431943006350 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 431943006351 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 431943006352 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 431943006353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943006354 active site 431943006355 phosphorylation site [posttranslational modification] 431943006356 intermolecular recognition site; other site 431943006357 dimerization interface [polypeptide binding]; other site 431943006358 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 431943006359 CheC-like family; Region: CheC; pfam04509 431943006360 CheC-like family; Region: CheC; pfam04509 431943006361 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 431943006362 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 431943006363 putative binding surface; other site 431943006364 active site 431943006365 P2 response regulator binding domain; Region: P2; pfam07194 431943006366 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 431943006367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006368 ATP binding site [chemical binding]; other site 431943006369 Mg2+ binding site [ion binding]; other site 431943006370 G-X-G motif; other site 431943006371 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 431943006372 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 431943006373 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 431943006374 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 431943006375 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 431943006376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943006377 active site 431943006378 phosphorylation site [posttranslational modification] 431943006379 intermolecular recognition site; other site 431943006380 dimerization interface [polypeptide binding]; other site 431943006381 CheB methylesterase; Region: CheB_methylest; pfam01339 431943006382 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 431943006383 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 431943006384 Protein of unknown function (DUF342); Region: DUF342; pfam03961 431943006385 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 431943006386 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 431943006387 homodimer interface [polypeptide binding]; other site 431943006388 substrate-cofactor binding pocket; other site 431943006389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006390 catalytic residue [active] 431943006391 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 431943006392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943006393 motif II; other site 431943006394 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 431943006395 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 431943006396 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 431943006397 dimer interface [polypeptide binding]; other site 431943006398 PYR/PP interface [polypeptide binding]; other site 431943006399 TPP binding site [chemical binding]; other site 431943006400 substrate binding site [chemical binding]; other site 431943006401 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 431943006402 Domain of unknown function; Region: EKR; smart00890 431943006403 4Fe-4S binding domain; Region: Fer4_6; pfam12837 431943006404 4Fe-4S binding domain; Region: Fer4; pfam00037 431943006405 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 431943006406 TPP-binding site [chemical binding]; other site 431943006407 dimer interface [polypeptide binding]; other site 431943006408 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 431943006409 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 431943006410 active site 431943006411 homodimer interface [polypeptide binding]; other site 431943006412 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 431943006413 DHH family; Region: DHH; pfam01368 431943006414 DHHA1 domain; Region: DHHA1; pfam02272 431943006415 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 431943006416 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 431943006417 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 431943006418 DJ-1 family protein; Region: not_thiJ; TIGR01383 431943006419 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 431943006420 conserved cys residue [active] 431943006421 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 431943006422 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 431943006423 CAP-like domain; other site 431943006424 active site 431943006425 primary dimer interface [polypeptide binding]; other site 431943006426 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 431943006427 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 431943006428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006429 ATP binding site [chemical binding]; other site 431943006430 Mg2+ binding site [ion binding]; other site 431943006431 G-X-G motif; other site 431943006432 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 431943006433 anchoring element; other site 431943006434 dimer interface [polypeptide binding]; other site 431943006435 ATP binding site [chemical binding]; other site 431943006436 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 431943006437 active site 431943006438 metal binding site [ion binding]; metal-binding site 431943006439 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 431943006440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943006441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943006442 dimerization interface [polypeptide binding]; other site 431943006443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943006444 dimer interface [polypeptide binding]; other site 431943006445 phosphorylation site [posttranslational modification] 431943006446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006447 ATP binding site [chemical binding]; other site 431943006448 Mg2+ binding site [ion binding]; other site 431943006449 G-X-G motif; other site 431943006450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943006451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943006452 active site 431943006453 phosphorylation site [posttranslational modification] 431943006454 intermolecular recognition site; other site 431943006455 dimerization interface [polypeptide binding]; other site 431943006456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943006457 DNA binding site [nucleotide binding] 431943006458 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 431943006459 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 431943006460 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 431943006461 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943006462 ACS interaction site; other site 431943006463 CODH interaction site; other site 431943006464 metal cluster binding site [ion binding]; other site 431943006465 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 431943006466 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 431943006467 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 431943006468 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 431943006469 G1 box; other site 431943006470 GTP/Mg2+ binding site [chemical binding]; other site 431943006471 Switch I region; other site 431943006472 G2 box; other site 431943006473 G3 box; other site 431943006474 Switch II region; other site 431943006475 G4 box; other site 431943006476 G5 box; other site 431943006477 Nucleoside recognition; Region: Gate; pfam07670 431943006478 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 431943006479 Nucleoside recognition; Region: Gate; pfam07670 431943006480 FeoA domain; Region: FeoA; pfam04023 431943006481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943006482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943006483 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 431943006484 tartrate dehydrogenase; Region: TTC; TIGR02089 431943006485 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 431943006486 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 431943006487 substrate binding site [chemical binding]; other site 431943006488 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 431943006489 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 431943006490 substrate binding site [chemical binding]; other site 431943006491 ligand binding site [chemical binding]; other site 431943006492 2-isopropylmalate synthase; Validated; Region: PRK00915 431943006493 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 431943006494 active site 431943006495 catalytic residues [active] 431943006496 metal binding site [ion binding]; metal-binding site 431943006497 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 431943006498 Cache domain; Region: Cache_2; cl07034 431943006499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943006500 dimerization interface [polypeptide binding]; other site 431943006501 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943006502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006503 dimer interface [polypeptide binding]; other site 431943006504 putative CheW interface [polypeptide binding]; other site 431943006505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 431943006506 Predicted secreted protein [Function unknown]; Region: COG4086 431943006507 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 431943006508 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 431943006509 flavodoxin; Provisional; Region: PRK05568 431943006510 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 431943006511 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 431943006512 homopentamer interface [polypeptide binding]; other site 431943006513 active site 431943006514 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 431943006515 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 431943006516 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 431943006517 dimerization interface [polypeptide binding]; other site 431943006518 active site 431943006519 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 431943006520 Lumazine binding domain; Region: Lum_binding; pfam00677 431943006521 Lumazine binding domain; Region: Lum_binding; pfam00677 431943006522 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 431943006523 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 431943006524 catalytic motif [active] 431943006525 Zn binding site [ion binding]; other site 431943006526 RibD C-terminal domain; Region: RibD_C; cl17279 431943006527 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943006528 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 431943006529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943006530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943006531 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 431943006532 Walker A/P-loop; other site 431943006533 ATP binding site [chemical binding]; other site 431943006534 Q-loop/lid; other site 431943006535 ABC transporter signature motif; other site 431943006536 Walker B; other site 431943006537 D-loop; other site 431943006538 H-loop/switch region; other site 431943006539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943006540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943006541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943006542 Walker A/P-loop; other site 431943006543 ATP binding site [chemical binding]; other site 431943006544 Q-loop/lid; other site 431943006545 ABC transporter signature motif; other site 431943006546 Walker B; other site 431943006547 D-loop; other site 431943006548 H-loop/switch region; other site 431943006549 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 431943006550 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 431943006551 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 431943006552 Walker A/P-loop; other site 431943006553 ATP binding site [chemical binding]; other site 431943006554 Q-loop/lid; other site 431943006555 ABC transporter signature motif; other site 431943006556 Walker B; other site 431943006557 D-loop; other site 431943006558 H-loop/switch region; other site 431943006559 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943006561 dimer interface [polypeptide binding]; other site 431943006562 conserved gate region; other site 431943006563 putative PBP binding loops; other site 431943006564 ABC-ATPase subunit interface; other site 431943006565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 431943006566 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 431943006567 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 431943006568 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 431943006569 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943006570 homodimer interface [polypeptide binding]; other site 431943006571 substrate-cofactor binding pocket; other site 431943006572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006573 catalytic residue [active] 431943006574 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 431943006575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 431943006576 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 431943006577 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943006578 homodimer interface [polypeptide binding]; other site 431943006579 substrate-cofactor binding pocket; other site 431943006580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006581 catalytic residue [active] 431943006582 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943006583 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943006584 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 431943006585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 431943006586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943006587 Coenzyme A binding pocket [chemical binding]; other site 431943006588 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 431943006589 substrate binding site [chemical binding]; other site 431943006590 THF binding site; other site 431943006591 zinc-binding site [ion binding]; other site 431943006592 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 431943006593 substrate binding site [chemical binding]; other site 431943006594 THF binding site; other site 431943006595 zinc-binding site [ion binding]; other site 431943006596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943006597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943006598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943006599 dimerization interface [polypeptide binding]; other site 431943006600 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 431943006601 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 431943006602 homodimer interface [polypeptide binding]; other site 431943006603 substrate-cofactor binding pocket; other site 431943006604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006605 catalytic residue [active] 431943006606 Domain of unknown function DUF21; Region: DUF21; pfam01595 431943006607 FOG: CBS domain [General function prediction only]; Region: COG0517 431943006608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 431943006609 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943006610 metal binding site 2 [ion binding]; metal-binding site 431943006611 putative DNA binding helix; other site 431943006612 metal binding site 1 [ion binding]; metal-binding site 431943006613 dimer interface [polypeptide binding]; other site 431943006614 structural Zn2+ binding site [ion binding]; other site 431943006615 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 431943006616 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 431943006617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943006618 RNA binding surface [nucleotide binding]; other site 431943006619 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 431943006620 active site 431943006621 catalytic triad [active] 431943006622 oxyanion hole [active] 431943006623 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943006624 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 431943006625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943006626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943006627 Walker A/P-loop; other site 431943006628 ATP binding site [chemical binding]; other site 431943006629 Q-loop/lid; other site 431943006630 ABC transporter signature motif; other site 431943006631 Walker B; other site 431943006632 D-loop; other site 431943006633 H-loop/switch region; other site 431943006634 Uncharacterized conserved protein [Function unknown]; Region: COG0432 431943006635 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 431943006636 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 431943006637 DNA binding residues [nucleotide binding] 431943006638 drug binding residues [chemical binding]; other site 431943006639 dimer interface [polypeptide binding]; other site 431943006640 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 431943006641 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 431943006642 Amidinotransferase; Region: Amidinotransf; pfam02274 431943006643 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 431943006644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943006645 motif II; other site 431943006646 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 431943006647 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 431943006648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943006649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943006650 DNA binding residues [nucleotide binding] 431943006651 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 431943006652 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 431943006653 folate binding site [chemical binding]; other site 431943006654 NADP+ binding site [chemical binding]; other site 431943006655 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 431943006656 nucleotide binding site/active site [active] 431943006657 HIT family signature motif; other site 431943006658 catalytic residue [active] 431943006659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943006660 active site 431943006661 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 431943006662 Thymidylate synthase complementing protein; Region: Thy1; cl03630 431943006663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 431943006664 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 431943006665 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 431943006666 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 431943006667 Response regulator receiver domain; Region: Response_reg; pfam00072 431943006668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943006669 active site 431943006670 phosphorylation site [posttranslational modification] 431943006671 intermolecular recognition site; other site 431943006672 dimerization interface [polypeptide binding]; other site 431943006673 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 431943006674 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 431943006675 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 431943006676 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 431943006677 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 431943006678 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 431943006679 NAD(P) binding site [chemical binding]; other site 431943006680 catalytic residues [active] 431943006681 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943006682 EamA-like transporter family; Region: EamA; pfam00892 431943006683 EamA-like transporter family; Region: EamA; pfam00892 431943006684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943006685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943006686 putative substrate translocation pore; other site 431943006687 heat shock protein 90; Provisional; Region: PRK05218 431943006688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006689 ATP binding site [chemical binding]; other site 431943006690 Mg2+ binding site [ion binding]; other site 431943006691 G-X-G motif; other site 431943006692 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 431943006693 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 431943006694 putative ligand binding site [chemical binding]; other site 431943006695 putative NAD binding site [chemical binding]; other site 431943006696 catalytic site [active] 431943006697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943006698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943006699 HlyD family secretion protein; Region: HlyD; pfam00529 431943006700 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 431943006701 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943006702 ABC-2 type transporter; Region: ABC2_membrane; cl17235 431943006703 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 431943006704 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 431943006705 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943006706 FeS/SAM binding site; other site 431943006707 hypothetical protein; Provisional; Region: PRK03881 431943006708 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 431943006709 AMMECR1; Region: AMMECR1; pfam01871 431943006710 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 431943006711 LysE type translocator; Region: LysE; cl00565 431943006712 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 431943006713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943006714 DNA-binding site [nucleotide binding]; DNA binding site 431943006715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943006716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943006717 homodimer interface [polypeptide binding]; other site 431943006718 catalytic residue [active] 431943006719 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943006720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943006721 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 431943006722 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943006723 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 431943006724 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943006725 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 431943006726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 431943006727 motif II; other site 431943006728 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 431943006729 Cache domain; Region: Cache_1; pfam02743 431943006730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943006731 dimerization interface [polypeptide binding]; other site 431943006732 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943006733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006734 dimer interface [polypeptide binding]; other site 431943006735 putative CheW interface [polypeptide binding]; other site 431943006736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943006737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 431943006738 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 431943006739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943006740 metal binding site [ion binding]; metal-binding site 431943006741 active site 431943006742 I-site; other site 431943006743 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943006744 Family description; Region: VCBS; pfam13517 431943006745 Penicillinase repressor; Region: Pencillinase_R; pfam03965 431943006746 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 431943006747 4Fe-4S binding domain; Region: Fer4; cl02805 431943006748 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 431943006749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006750 dimer interface [polypeptide binding]; other site 431943006751 putative CheW interface [polypeptide binding]; other site 431943006752 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943006753 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943006754 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943006755 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943006756 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 431943006757 metal-binding site [ion binding] 431943006758 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943006759 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943006760 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 431943006761 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 431943006762 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 431943006763 Helix-turn-helix domain; Region: HTH_18; pfam12833 431943006764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943006765 Cupin domain; Region: Cupin_2; cl17218 431943006766 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 431943006767 BioY family; Region: BioY; pfam02632 431943006768 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 431943006769 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943006770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 431943006771 dimerization interface [polypeptide binding]; other site 431943006772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006773 dimer interface [polypeptide binding]; other site 431943006774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943006775 putative CheW interface [polypeptide binding]; other site 431943006776 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943006777 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943006778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943006779 dimer interface [polypeptide binding]; other site 431943006780 putative CheW interface [polypeptide binding]; other site 431943006781 polyphosphate kinase; Provisional; Region: PRK05443 431943006782 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 431943006783 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 431943006784 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 431943006785 putative domain interface [polypeptide binding]; other site 431943006786 putative active site [active] 431943006787 catalytic site [active] 431943006788 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 431943006789 putative domain interface [polypeptide binding]; other site 431943006790 putative active site [active] 431943006791 catalytic site [active] 431943006792 exopolyphosphatase; Region: exo_poly_only; TIGR03706 431943006793 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 431943006794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 431943006795 exopolyphosphatase; Region: exo_poly_only; TIGR03706 431943006796 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 431943006797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943006798 Zn2+ binding site [ion binding]; other site 431943006799 Mg2+ binding site [ion binding]; other site 431943006800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943006801 H+ Antiporter protein; Region: 2A0121; TIGR00900 431943006802 putative substrate translocation pore; other site 431943006803 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 431943006804 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 431943006805 catalytic loop [active] 431943006806 iron binding site [ion binding]; other site 431943006807 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 431943006808 4Fe-4S binding domain; Region: Fer4; pfam00037 431943006809 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 431943006810 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 431943006811 Protein of unknown function (DUF503); Region: DUF503; pfam04456 431943006812 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 431943006813 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 431943006814 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 431943006815 active site 431943006816 oxyanion hole [active] 431943006817 catalytic triad [active] 431943006818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943006819 putative substrate translocation pore; other site 431943006820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943006821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943006822 active site 431943006823 phosphorylation site [posttranslational modification] 431943006824 intermolecular recognition site; other site 431943006825 dimerization interface [polypeptide binding]; other site 431943006826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943006827 DNA binding site [nucleotide binding] 431943006828 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 431943006829 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 431943006830 Ligand Binding Site [chemical binding]; other site 431943006831 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 431943006832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943006833 phosphorylation site [posttranslational modification] 431943006834 dimer interface [polypeptide binding]; other site 431943006835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006836 ATP binding site [chemical binding]; other site 431943006837 Mg2+ binding site [ion binding]; other site 431943006838 G-X-G motif; other site 431943006839 Amino acid permease; Region: AA_permease_2; pfam13520 431943006840 Membrane transport protein; Region: Mem_trans; pfam03547 431943006841 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943006842 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943006843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943006844 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943006845 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 431943006846 active site 431943006847 catalytic triad [active] 431943006848 oxyanion hole [active] 431943006849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 431943006850 E3 interaction surface; other site 431943006851 lipoyl attachment site [posttranslational modification]; other site 431943006852 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 431943006853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943006854 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 431943006855 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 431943006856 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 431943006857 E3 interaction surface; other site 431943006858 lipoyl attachment site [posttranslational modification]; other site 431943006859 e3 binding domain; Region: E3_binding; pfam02817 431943006860 e3 binding domain; Region: E3_binding; pfam02817 431943006861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 431943006862 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 431943006863 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 431943006864 alpha subunit interface [polypeptide binding]; other site 431943006865 TPP binding site [chemical binding]; other site 431943006866 heterodimer interface [polypeptide binding]; other site 431943006867 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 431943006868 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 431943006869 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 431943006870 tetramer interface [polypeptide binding]; other site 431943006871 TPP-binding site [chemical binding]; other site 431943006872 heterodimer interface [polypeptide binding]; other site 431943006873 phosphorylation loop region [posttranslational modification] 431943006874 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 431943006875 GAF domain; Region: GAF; pfam01590 431943006876 PAS domain; Region: PAS; smart00091 431943006877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943006878 Walker A motif; other site 431943006879 ATP binding site [chemical binding]; other site 431943006880 Walker B motif; other site 431943006881 arginine finger; other site 431943006882 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 431943006883 lipoyl synthase; Provisional; Region: PRK05481 431943006884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943006885 FeS/SAM binding site; other site 431943006886 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 431943006887 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 431943006888 CAAX protease self-immunity; Region: Abi; pfam02517 431943006889 Helix-turn-helix domain; Region: HTH_38; pfam13936 431943006890 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 431943006891 Integrase core domain; Region: rve; pfam00665 431943006892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943006893 non-specific DNA binding site [nucleotide binding]; other site 431943006894 salt bridge; other site 431943006895 sequence-specific DNA binding site [nucleotide binding]; other site 431943006896 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943006897 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 431943006898 NodB motif; other site 431943006899 active site 431943006900 catalytic site [active] 431943006901 Zn binding site [ion binding]; other site 431943006902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943006903 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943006904 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943006905 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 431943006906 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 431943006907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943006908 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943006909 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943006910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943006911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943006912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943006913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943006914 Walker A/P-loop; other site 431943006915 ATP binding site [chemical binding]; other site 431943006916 Q-loop/lid; other site 431943006917 ABC transporter signature motif; other site 431943006918 Walker B; other site 431943006919 D-loop; other site 431943006920 H-loop/switch region; other site 431943006921 FtsX-like permease family; Region: FtsX; pfam02687 431943006922 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 431943006923 FtsX-like permease family; Region: FtsX; pfam02687 431943006924 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 431943006925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943006926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943006927 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943006928 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 431943006929 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 431943006930 Small acid-soluble spore protein H family; Region: SspH; pfam08141 431943006931 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 431943006932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943006933 Coenzyme A binding pocket [chemical binding]; other site 431943006934 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943006935 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 431943006936 Walker A/P-loop; other site 431943006937 ATP binding site [chemical binding]; other site 431943006938 Q-loop/lid; other site 431943006939 ABC transporter signature motif; other site 431943006940 Walker B; other site 431943006941 D-loop; other site 431943006942 H-loop/switch region; other site 431943006943 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943006944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943006945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943006946 DNA binding residues [nucleotide binding] 431943006947 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 431943006948 metal-binding site [ion binding] 431943006949 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 431943006950 Heavy-metal-associated domain; Region: HMA; pfam00403 431943006951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943006952 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943006953 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943006954 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 431943006955 putative active site [active] 431943006956 putative metal binding site [ion binding]; other site 431943006957 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 431943006958 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 431943006959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943006960 MarR family; Region: MarR_2; pfam12802 431943006961 Methyltransferase domain; Region: Methyltransf_23; pfam13489 431943006962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943006963 S-adenosylmethionine binding site [chemical binding]; other site 431943006964 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 431943006965 active site 431943006966 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 431943006967 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 431943006968 active site 431943006969 Zn binding site [ion binding]; other site 431943006970 asparagine synthetase B; Provisional; Region: asnB; PRK09431 431943006971 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 431943006972 dimer interface [polypeptide binding]; other site 431943006973 active site 431943006974 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 431943006975 Ligand Binding Site [chemical binding]; other site 431943006976 Molecular Tunnel; other site 431943006977 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 431943006978 HSP70 interaction site [polypeptide binding]; other site 431943006979 Tetratricopeptide repeat; Region: TPR_16; pfam13432 431943006980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943006981 TPR motif; other site 431943006982 binding surface 431943006983 TPR repeat; Region: TPR_11; pfam13414 431943006984 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 431943006985 DNA adenine methylase (dam); Region: dam; TIGR00571 431943006986 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 431943006987 TfoX C-terminal domain; Region: TfoX_C; pfam04994 431943006988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943006989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943006990 putative substrate translocation pore; other site 431943006991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943006992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943006993 dimer interface [polypeptide binding]; other site 431943006994 phosphorylation site [posttranslational modification] 431943006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943006996 ATP binding site [chemical binding]; other site 431943006997 Mg2+ binding site [ion binding]; other site 431943006998 G-X-G motif; other site 431943006999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943007000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943007001 Walker A/P-loop; other site 431943007002 ATP binding site [chemical binding]; other site 431943007003 Q-loop/lid; other site 431943007004 ABC transporter signature motif; other site 431943007005 Walker B; other site 431943007006 D-loop; other site 431943007007 H-loop/switch region; other site 431943007008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943007009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943007010 active site 431943007011 phosphorylation site [posttranslational modification] 431943007012 intermolecular recognition site; other site 431943007013 dimerization interface [polypeptide binding]; other site 431943007014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943007015 DNA binding site [nucleotide binding] 431943007016 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 431943007017 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 431943007018 active site 431943007019 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 431943007020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943007021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943007022 dimer interface [polypeptide binding]; other site 431943007023 putative CheW interface [polypeptide binding]; other site 431943007024 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943007025 4Fe-4S binding domain; Region: Fer4; pfam00037 431943007026 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943007027 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 431943007028 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 431943007029 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007030 ABC transporter; Region: ABC_tran_2; pfam12848 431943007031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007032 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 431943007033 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 431943007034 G1 box; other site 431943007035 GTP/Mg2+ binding site [chemical binding]; other site 431943007036 Switch I region; other site 431943007037 G2 box; other site 431943007038 Switch II region; other site 431943007039 G3 box; other site 431943007040 G4 box; other site 431943007041 G5 box; other site 431943007042 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 431943007043 Aspartase; Region: Aspartase; cd01357 431943007044 active sites [active] 431943007045 tetramer interface [polypeptide binding]; other site 431943007046 YibE/F-like protein; Region: YibE_F; pfam07907 431943007047 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 431943007048 Clp amino terminal domain; Region: Clp_N; pfam02861 431943007049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943007050 Walker A motif; other site 431943007051 ATP binding site [chemical binding]; other site 431943007052 Walker B motif; other site 431943007053 arginine finger; other site 431943007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943007055 Walker A motif; other site 431943007056 ATP binding site [chemical binding]; other site 431943007057 Walker B motif; other site 431943007058 arginine finger; other site 431943007059 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 431943007060 Uncharacterized conserved protein [Function unknown]; Region: COG2127 431943007061 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 431943007062 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943007063 nucleotide binding site [chemical binding]; other site 431943007064 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943007065 SBD interface [polypeptide binding]; other site 431943007066 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 431943007067 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943007068 nucleotide binding site [chemical binding]; other site 431943007069 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943007070 SBD interface [polypeptide binding]; other site 431943007071 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 431943007072 dimer interface [polypeptide binding]; other site 431943007073 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 431943007074 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943007075 rod shape-determining protein MreB; Provisional; Region: PRK13930 431943007076 nucleotide binding site [chemical binding]; other site 431943007077 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943007078 SBD interface [polypeptide binding]; other site 431943007079 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 431943007080 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 431943007081 nucleotide binding site [chemical binding]; other site 431943007082 putative NEF/HSP70 interaction site [polypeptide binding]; other site 431943007083 SBD interface [polypeptide binding]; other site 431943007084 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 431943007085 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 431943007086 putative metal binding site [ion binding]; other site 431943007087 KWG Leptospira; Region: KWG; pfam07656 431943007088 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 431943007089 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943007090 Transcriptional regulator PadR-like family; Region: PadR; cl17335 431943007091 EDD domain protein, DegV family; Region: DegV; TIGR00762 431943007092 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 431943007093 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 431943007094 Sulfatase; Region: Sulfatase; pfam00884 431943007095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943007096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943007097 dimerization interface [polypeptide binding]; other site 431943007098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943007099 dimer interface [polypeptide binding]; other site 431943007100 phosphorylation site [posttranslational modification] 431943007101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943007102 ATP binding site [chemical binding]; other site 431943007103 Mg2+ binding site [ion binding]; other site 431943007104 G-X-G motif; other site 431943007105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943007106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943007107 active site 431943007108 phosphorylation site [posttranslational modification] 431943007109 intermolecular recognition site; other site 431943007110 dimerization interface [polypeptide binding]; other site 431943007111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943007112 DNA binding site [nucleotide binding] 431943007113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943007114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943007115 dimer interface [polypeptide binding]; other site 431943007116 putative CheW interface [polypeptide binding]; other site 431943007117 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 431943007118 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943007119 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 431943007120 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 431943007121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007122 S-adenosylmethionine binding site [chemical binding]; other site 431943007123 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 431943007124 acyl-activating enzyme (AAE) consensus motif; other site 431943007125 AMP binding site [chemical binding]; other site 431943007126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943007127 thioester reductase domain; Region: Thioester-redct; TIGR01746 431943007128 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 431943007129 putative NAD(P) binding site [chemical binding]; other site 431943007130 active site 431943007131 putative substrate binding site [chemical binding]; other site 431943007132 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 431943007133 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 431943007134 active site 431943007135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943007136 Condensation domain; Region: Condensation; pfam00668 431943007137 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 431943007138 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 431943007139 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 431943007140 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 431943007141 acyl-CoA synthetase; Validated; Region: PRK09192 431943007142 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 431943007143 acyl-activating enzyme (AAE) consensus motif; other site 431943007144 putative AMP binding site [chemical binding]; other site 431943007145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 431943007146 FtsX-like permease family; Region: FtsX; pfam02687 431943007147 FtsX-like permease family; Region: FtsX; pfam02687 431943007148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943007149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943007150 Walker A/P-loop; other site 431943007151 ATP binding site [chemical binding]; other site 431943007152 Q-loop/lid; other site 431943007153 ABC transporter signature motif; other site 431943007154 Walker B; other site 431943007155 D-loop; other site 431943007156 H-loop/switch region; other site 431943007157 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 431943007158 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 431943007159 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943007160 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943007161 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943007162 Walker A/P-loop; other site 431943007163 ATP binding site [chemical binding]; other site 431943007164 Q-loop/lid; other site 431943007165 ABC transporter signature motif; other site 431943007166 Walker B; other site 431943007167 D-loop; other site 431943007168 H-loop/switch region; other site 431943007169 Predicted transcriptional regulators [Transcription]; Region: COG1725 431943007170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943007171 DNA-binding site [nucleotide binding]; DNA binding site 431943007172 putative transposase OrfB; Reviewed; Region: PHA02517 431943007173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943007174 Transcriptional regulators [Transcription]; Region: MarR; COG1846 431943007175 MarR family; Region: MarR_2; pfam12802 431943007176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 431943007177 Sterol carrier protein domain; Region: SCP2_2; pfam13530 431943007178 Integrase core domain; Region: rve; pfam00665 431943007179 Integrase core domain; Region: rve_3; pfam13683 431943007180 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 431943007181 Putative amidase domain; Region: Amidase_6; pfam12671 431943007182 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 431943007183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943007184 non-specific DNA binding site [nucleotide binding]; other site 431943007185 salt bridge; other site 431943007186 sequence-specific DNA binding site [nucleotide binding]; other site 431943007187 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 431943007188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943007189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 431943007190 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 431943007191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 431943007192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 431943007193 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 431943007194 substrate binding site [chemical binding]; other site 431943007195 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 431943007196 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 431943007197 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 431943007198 catalytic site [active] 431943007199 subunit interface [polypeptide binding]; other site 431943007200 ornithine carbamoyltransferase; Validated; Region: PRK02102 431943007201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 431943007202 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 431943007203 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 431943007204 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943007205 substrate binding pocket [chemical binding]; other site 431943007206 membrane-bound complex binding site; other site 431943007207 hinge residues; other site 431943007208 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 431943007209 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 431943007210 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 431943007211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943007212 ATP binding site [chemical binding]; other site 431943007213 putative Mg++ binding site [ion binding]; other site 431943007214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943007215 nucleotide binding region [chemical binding]; other site 431943007216 ATP-binding site [chemical binding]; other site 431943007217 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 431943007218 HRDC domain; Region: HRDC; pfam00570 431943007219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943007220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943007221 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 431943007222 putative dimerization interface [polypeptide binding]; other site 431943007223 Predicted membrane protein [Function unknown]; Region: COG2855 431943007224 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 431943007225 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 431943007226 catalytic residues [active] 431943007227 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 431943007228 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 431943007229 active site 431943007230 metal binding site [ion binding]; metal-binding site 431943007231 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 431943007232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943007233 ATP binding site [chemical binding]; other site 431943007234 Mg2+ binding site [ion binding]; other site 431943007235 G-X-G motif; other site 431943007236 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 431943007237 Protein export membrane protein; Region: SecD_SecF; cl14618 431943007238 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 431943007239 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 431943007240 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943007241 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 431943007242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007243 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 431943007244 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943007245 Transcriptional regulator PadR-like family; Region: PadR; cl17335 431943007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007247 putative transporter; Provisional; Region: PRK10504 431943007248 putative substrate translocation pore; other site 431943007249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943007250 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943007251 Walker A/P-loop; other site 431943007252 ATP binding site [chemical binding]; other site 431943007253 Q-loop/lid; other site 431943007254 ABC transporter signature motif; other site 431943007255 Walker B; other site 431943007256 D-loop; other site 431943007257 H-loop/switch region; other site 431943007258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943007259 dimer interface [polypeptide binding]; other site 431943007260 conserved gate region; other site 431943007261 putative PBP binding loops; other site 431943007262 ABC-ATPase subunit interface; other site 431943007263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 431943007264 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 431943007265 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 431943007266 classical (c) SDRs; Region: SDR_c; cd05233 431943007267 NAD(P) binding site [chemical binding]; other site 431943007268 active site 431943007269 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 431943007270 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 431943007271 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 431943007272 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 431943007273 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 431943007274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 431943007275 active site 431943007276 ATP binding site [chemical binding]; other site 431943007277 substrate binding site [chemical binding]; other site 431943007278 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 431943007279 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 431943007280 homodimer interface [polypeptide binding]; other site 431943007281 active site 431943007282 FMN binding site [chemical binding]; other site 431943007283 substrate binding site [chemical binding]; other site 431943007284 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 431943007285 phenylhydantoinase; Validated; Region: PRK08323 431943007286 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 431943007287 tetramer interface [polypeptide binding]; other site 431943007288 active site 431943007289 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 431943007290 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 431943007291 Na binding site [ion binding]; other site 431943007292 putative substrate binding site [chemical binding]; other site 431943007293 allantoate amidohydrolase; Reviewed; Region: PRK09290 431943007294 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 431943007295 active site 431943007296 metal binding site [ion binding]; metal-binding site 431943007297 dimer interface [polypeptide binding]; other site 431943007298 hypothetical protein; Provisional; Region: PRK06062 431943007299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943007300 inhibitor-cofactor binding pocket; inhibition site 431943007301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943007302 catalytic residue [active] 431943007303 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943007304 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 431943007305 putative active site [active] 431943007306 metal binding site [ion binding]; metal-binding site 431943007307 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 431943007308 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 431943007309 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 431943007310 agmatinase; Region: agmatinase; TIGR01230 431943007311 oligomer interface [polypeptide binding]; other site 431943007312 putative active site [active] 431943007313 Mn binding site [ion binding]; other site 431943007314 Malic enzyme, N-terminal domain; Region: malic; pfam00390 431943007315 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 431943007316 putative NAD(P) binding site [chemical binding]; other site 431943007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943007319 putative substrate translocation pore; other site 431943007320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007321 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 431943007322 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 431943007323 ribonuclease Z; Reviewed; Region: PRK00055 431943007324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943007325 non-specific DNA binding site [nucleotide binding]; other site 431943007326 salt bridge; other site 431943007327 sequence-specific DNA binding site [nucleotide binding]; other site 431943007328 Cache domain; Region: Cache_1; pfam02743 431943007329 HAMP domain; Region: HAMP; pfam00672 431943007330 dimerization interface [polypeptide binding]; other site 431943007331 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943007332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943007333 dimer interface [polypeptide binding]; other site 431943007334 putative CheW interface [polypeptide binding]; other site 431943007335 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 431943007336 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 431943007337 predicted active site [active] 431943007338 catalytic triad [active] 431943007339 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 431943007340 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 431943007341 active site 431943007342 multimer interface [polypeptide binding]; other site 431943007343 Uncharacterized conserved protein [Function unknown]; Region: COG3379 431943007344 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 431943007345 Biotin operon repressor [Transcription]; Region: BirA; COG1654 431943007346 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 431943007347 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 431943007348 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 431943007349 isoaspartyl dipeptidase; Provisional; Region: PRK10657 431943007350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943007351 active site 431943007352 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 431943007353 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 431943007354 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 431943007355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 431943007356 ligand binding site [chemical binding]; other site 431943007357 flexible hinge region; other site 431943007358 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 431943007359 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 431943007360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943007361 Zn2+ binding site [ion binding]; other site 431943007362 Mg2+ binding site [ion binding]; other site 431943007363 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 431943007364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 431943007365 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 431943007366 active site 431943007367 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 431943007368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007369 S-adenosylmethionine binding site [chemical binding]; other site 431943007370 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 431943007371 putative metal binding site; other site 431943007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943007373 binding surface 431943007374 TPR motif; other site 431943007375 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 431943007376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943007377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943007378 putative Zn2+ binding site [ion binding]; other site 431943007379 putative DNA binding site [nucleotide binding]; other site 431943007380 dimerization interface [polypeptide binding]; other site 431943007381 H+ Antiporter protein; Region: 2A0121; TIGR00900 431943007382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007383 putative substrate translocation pore; other site 431943007384 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 431943007385 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 431943007386 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 431943007387 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 431943007388 Putative amidase domain; Region: Amidase_6; pfam12671 431943007389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943007390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007391 S-adenosylmethionine binding site [chemical binding]; other site 431943007392 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 431943007393 methionine sulfoxide reductase B; Provisional; Region: PRK00222 431943007394 SelR domain; Region: SelR; pfam01641 431943007395 Predicted integral membrane protein [Function unknown]; Region: COG5658 431943007396 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 431943007397 SdpI/YhfL protein family; Region: SdpI; pfam13630 431943007398 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 431943007399 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943007400 DNA binding residues [nucleotide binding] 431943007401 dimer interface [polypeptide binding]; other site 431943007402 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 431943007403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943007404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943007405 active site 431943007406 dimerization interface [polypeptide binding]; other site 431943007407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943007408 DNA binding site [nucleotide binding] 431943007409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943007410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943007411 dimer interface [polypeptide binding]; other site 431943007412 phosphorylation site [posttranslational modification] 431943007413 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 431943007414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943007415 Walker A/P-loop; other site 431943007416 ATP binding site [chemical binding]; other site 431943007417 Q-loop/lid; other site 431943007418 Walker B; other site 431943007419 D-loop; other site 431943007420 ABC-2 type transporter; Region: ABC2_membrane; cl17235 431943007421 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 431943007422 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943007423 MarR family; Region: MarR_2; pfam12802 431943007424 Amidase; Region: Amidase; cl11426 431943007425 hybrid cluster protein; Provisional; Region: PRK05290 431943007426 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943007427 ACS interaction site; other site 431943007428 CODH interaction site; other site 431943007429 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 431943007430 hybrid metal cluster; other site 431943007431 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 431943007432 LemA family; Region: LemA; cl00742 431943007433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943007434 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943007435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943007436 Walker A/P-loop; other site 431943007437 ATP binding site [chemical binding]; other site 431943007438 Q-loop/lid; other site 431943007439 ABC transporter signature motif; other site 431943007440 Walker B; other site 431943007441 D-loop; other site 431943007442 H-loop/switch region; other site 431943007443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943007444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943007445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943007446 Walker A/P-loop; other site 431943007447 ATP binding site [chemical binding]; other site 431943007448 Q-loop/lid; other site 431943007449 ABC transporter signature motif; other site 431943007450 Walker B; other site 431943007451 D-loop; other site 431943007452 H-loop/switch region; other site 431943007453 Helix-turn-helix domain; Region: HTH_18; pfam12833 431943007454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943007455 Pirin-related protein [General function prediction only]; Region: COG1741 431943007456 Pirin; Region: Pirin; pfam02678 431943007457 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 431943007458 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943007459 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943007460 TIGR03943 family protein; Region: TIGR03943 431943007461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943007462 Predicted permeases [General function prediction only]; Region: COG0701 431943007463 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 431943007464 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 431943007465 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 431943007466 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 431943007467 TrkA-N domain; Region: TrkA_N; pfam02254 431943007468 TrkA-C domain; Region: TrkA_C; pfam02080 431943007469 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 431943007470 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 431943007471 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943007472 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943007473 active site 431943007474 FMN binding site [chemical binding]; other site 431943007475 substrate binding site [chemical binding]; other site 431943007476 putative catalytic residue [active] 431943007477 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 431943007478 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 431943007479 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943007480 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 431943007481 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943007482 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943007483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943007484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 431943007485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943007486 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 431943007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943007489 putative substrate translocation pore; other site 431943007490 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 431943007491 ligand binding site; other site 431943007492 tetramer interface; other site 431943007493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 431943007494 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 431943007495 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 431943007496 Substrate binding site; other site 431943007497 metal-binding site 431943007498 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 431943007499 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 431943007500 inhibitor-cofactor binding pocket; inhibition site 431943007501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943007502 catalytic residue [active] 431943007503 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 431943007504 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 431943007505 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 431943007506 active site 431943007507 homodimer interface [polypeptide binding]; other site 431943007508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 431943007509 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 431943007510 NeuB family; Region: NeuB; pfam03102 431943007511 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 431943007512 NeuB binding interface [polypeptide binding]; other site 431943007513 putative substrate binding site [chemical binding]; other site 431943007514 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 431943007515 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 431943007516 putative trimer interface [polypeptide binding]; other site 431943007517 putative CoA binding site [chemical binding]; other site 431943007518 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 431943007519 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 431943007520 NAD binding site [chemical binding]; other site 431943007521 substrate binding site [chemical binding]; other site 431943007522 active site 431943007523 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 431943007524 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 431943007525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 431943007526 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 431943007527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007528 S-adenosylmethionine binding site [chemical binding]; other site 431943007529 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 431943007530 DNA binding residues [nucleotide binding] 431943007531 Cache domain; Region: Cache_1; pfam02743 431943007532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 431943007533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943007534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943007535 dimer interface [polypeptide binding]; other site 431943007536 putative CheW interface [polypeptide binding]; other site 431943007537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943007538 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943007539 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943007540 Walker A/P-loop; other site 431943007541 ATP binding site [chemical binding]; other site 431943007542 Q-loop/lid; other site 431943007543 ABC transporter signature motif; other site 431943007544 Walker B; other site 431943007545 D-loop; other site 431943007546 H-loop/switch region; other site 431943007547 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 431943007548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943007549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943007550 non-specific DNA binding site [nucleotide binding]; other site 431943007551 salt bridge; other site 431943007552 sequence-specific DNA binding site [nucleotide binding]; other site 431943007553 AMMECR1; Region: AMMECR1; cl00911 431943007554 ABC-2 type transporter; Region: ABC2_membrane; cl17235 431943007555 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 431943007556 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 431943007557 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943007558 Walker A/P-loop; other site 431943007559 ATP binding site [chemical binding]; other site 431943007560 Q-loop/lid; other site 431943007561 ABC transporter signature motif; other site 431943007562 Walker B; other site 431943007563 D-loop; other site 431943007564 H-loop/switch region; other site 431943007565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007566 WHG domain; Region: WHG; pfam13305 431943007567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 431943007568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007570 WHG domain; Region: WHG; pfam13305 431943007571 drug efflux system protein MdtG; Provisional; Region: PRK09874 431943007572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007573 putative substrate translocation pore; other site 431943007574 Isochorismatase family; Region: Isochorismatase; pfam00857 431943007575 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 431943007576 catalytic triad [active] 431943007577 conserved cis-peptide bond; other site 431943007578 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 431943007579 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 431943007580 Walker A/P-loop; other site 431943007581 ATP binding site [chemical binding]; other site 431943007582 Q-loop/lid; other site 431943007583 ABC transporter signature motif; other site 431943007584 Walker B; other site 431943007585 D-loop; other site 431943007586 H-loop/switch region; other site 431943007587 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 431943007588 cobalt transport protein CbiM; Provisional; Region: PRK07331 431943007589 cobalt transport protein CbiM; Provisional; Region: PRK11909 431943007590 PDGLE domain; Region: PDGLE; pfam13190 431943007591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007593 S-adenosylmethionine binding site [chemical binding]; other site 431943007594 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 431943007595 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 431943007596 Ligand Binding Site [chemical binding]; other site 431943007597 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 431943007598 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 431943007599 DNA binding residues [nucleotide binding] 431943007600 putative dimer interface [polypeptide binding]; other site 431943007601 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 431943007602 TfoX C-terminal domain; Region: TfoX_C; pfam04994 431943007603 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943007604 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 431943007605 intersubunit interface [polypeptide binding]; other site 431943007606 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943007607 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 431943007608 intersubunit interface [polypeptide binding]; other site 431943007609 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 431943007610 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 431943007611 Walker A/P-loop; other site 431943007612 ATP binding site [chemical binding]; other site 431943007613 Q-loop/lid; other site 431943007614 ABC transporter signature motif; other site 431943007615 Walker B; other site 431943007616 D-loop; other site 431943007617 H-loop/switch region; other site 431943007618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 431943007619 ABC-ATPase subunit interface; other site 431943007620 dimer interface [polypeptide binding]; other site 431943007621 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 431943007622 putative PBP binding regions; other site 431943007623 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 431943007624 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943007625 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 431943007626 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943007627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943007628 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 431943007629 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 431943007630 active site 431943007631 EDD domain protein, DegV family; Region: DegV; TIGR00762 431943007632 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 431943007633 flavodoxin; Provisional; Region: PRK06242 431943007634 FMN-binding domain; Region: FMN_bind; cl01081 431943007635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007638 H+ Antiporter protein; Region: 2A0121; TIGR00900 431943007639 putative substrate translocation pore; other site 431943007640 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 431943007641 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 431943007642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 431943007643 MarR family; Region: MarR_2; pfam12802 431943007644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943007645 Coenzyme A binding pocket [chemical binding]; other site 431943007646 HTH-like domain; Region: HTH_21; pfam13276 431943007647 Integrase core domain; Region: rve; pfam00665 431943007648 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943007649 Integrase core domain; Region: rve_3; pfam13683 431943007650 Transposase; Region: HTH_Tnp_1; cl17663 431943007651 Transcriptional regulators [Transcription]; Region: FadR; COG2186 431943007652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943007653 DNA-binding site [nucleotide binding]; DNA binding site 431943007654 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 431943007655 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 431943007656 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 431943007657 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 431943007658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 431943007659 substrate binding site [chemical binding]; other site 431943007660 oxyanion hole (OAH) forming residues; other site 431943007661 trimer interface [polypeptide binding]; other site 431943007662 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 431943007663 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943007664 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 431943007665 Part of AAA domain; Region: AAA_19; pfam13245 431943007666 Family description; Region: UvrD_C_2; pfam13538 431943007667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007669 Acyltransferase family; Region: Acyl_transf_3; pfam01757 431943007670 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 431943007671 Low molecular weight phosphatase family; Region: LMWPc; cl00105 431943007672 active site 431943007673 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 431943007674 arsenical-resistance protein; Region: acr3; TIGR00832 431943007675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943007676 dimerization interface [polypeptide binding]; other site 431943007677 putative DNA binding site [nucleotide binding]; other site 431943007678 putative Zn2+ binding site [ion binding]; other site 431943007679 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 431943007680 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 431943007681 trimer interface [polypeptide binding]; other site 431943007682 active site 431943007683 substrate binding site [chemical binding]; other site 431943007684 CoA binding site [chemical binding]; other site 431943007685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007686 ABC transporter; Region: ABC_tran; pfam00005 431943007687 ABC transporter; Region: ABC_tran_2; pfam12848 431943007688 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 431943007689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007690 HTH-like domain; Region: HTH_21; pfam13276 431943007691 Integrase core domain; Region: rve; pfam00665 431943007692 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943007693 Integrase core domain; Region: rve_3; pfam13683 431943007694 Transposase; Region: HTH_Tnp_1; cl17663 431943007695 Phospholipid methyltransferase; Region: PEMT; cl17370 431943007696 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943007697 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943007698 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 431943007699 Amidohydrolase; Region: Amidohydro_2; pfam04909 431943007700 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 431943007701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943007702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943007703 active site 431943007704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943007705 dimer interface [polypeptide binding]; other site 431943007706 phosphorylation site [posttranslational modification] 431943007707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943007708 ATP binding site [chemical binding]; other site 431943007709 Mg2+ binding site [ion binding]; other site 431943007710 G-X-G motif; other site 431943007711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943007712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943007713 active site 431943007714 phosphorylation site [posttranslational modification] 431943007715 intermolecular recognition site; other site 431943007716 dimerization interface [polypeptide binding]; other site 431943007717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943007718 DNA binding site [nucleotide binding] 431943007719 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 431943007720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943007721 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 431943007722 DNA binding site [nucleotide binding] 431943007723 sequence specific DNA binding site [nucleotide binding]; other site 431943007724 putative cAMP binding site [chemical binding]; other site 431943007725 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 431943007726 SdpI/YhfL protein family; Region: SdpI; pfam13630 431943007727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943007728 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 431943007729 Putative esterase; Region: Esterase; pfam00756 431943007730 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 431943007731 dimer interface [polypeptide binding]; other site 431943007732 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 431943007733 FMN binding site [chemical binding]; other site 431943007734 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 431943007735 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 431943007736 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 431943007737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943007738 ATP binding site [chemical binding]; other site 431943007739 putative Mg++ binding site [ion binding]; other site 431943007740 nucleotide binding region [chemical binding]; other site 431943007741 helicase superfamily c-terminal domain; Region: HELICc; smart00490 431943007742 ATP-binding site [chemical binding]; other site 431943007743 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 431943007744 PLD-like domain; Region: PLDc_2; pfam13091 431943007745 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 431943007746 Preprotein binding site; other site 431943007747 SecA binding site; other site 431943007748 Restriction endonuclease [Defense mechanisms]; Region: COG3587 431943007749 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 431943007750 ATP binding site [chemical binding]; other site 431943007751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943007752 salt bridge; other site 431943007753 non-specific DNA binding site [nucleotide binding]; other site 431943007754 sequence-specific DNA binding site [nucleotide binding]; other site 431943007755 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 431943007756 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943007757 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943007758 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 431943007759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007761 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 431943007762 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943007763 active site 431943007764 FMN binding site [chemical binding]; other site 431943007765 substrate binding site [chemical binding]; other site 431943007766 putative catalytic residue [active] 431943007767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943007768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 431943007769 Flavodoxin domain; Region: Flavodoxin_5; cl17428 431943007770 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 431943007771 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943007772 CRISPR/Cas system-associated protein Csa8a2; Region: Cas8a2_I-A; cl09907 431943007773 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 431943007774 classical (c) SDRs; Region: SDR_c; cd05233 431943007775 NAD(P) binding site [chemical binding]; other site 431943007776 active site 431943007777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943007778 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 431943007779 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 431943007780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943007781 FeS/SAM binding site; other site 431943007782 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 431943007783 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 431943007784 4Fe-4S binding domain; Region: Fer4; pfam00037 431943007785 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943007786 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 431943007787 classical (c) SDRs; Region: SDR_c; cd05233 431943007788 NAD(P) binding site [chemical binding]; other site 431943007789 active site 431943007790 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 431943007791 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 431943007792 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 431943007793 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 431943007794 Propionate catabolism activator; Region: PrpR_N; pfam06506 431943007795 PAS domain S-box; Region: sensory_box; TIGR00229 431943007796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943007797 putative active site [active] 431943007798 heme pocket [chemical binding]; other site 431943007799 Radical SAM superfamily; Region: Radical_SAM; pfam04055 431943007800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943007801 FeS/SAM binding site; other site 431943007802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943007803 MarR family; Region: MarR_2; pfam12802 431943007804 MarR family; Region: MarR_2; cl17246 431943007805 benzoate transport; Region: 2A0115; TIGR00895 431943007806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007807 putative substrate translocation pore; other site 431943007808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 431943007810 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 431943007811 GIY-YIG motif/motif A; other site 431943007812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 431943007813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 431943007814 DNA binding residues [nucleotide binding] 431943007815 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 431943007816 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 431943007817 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 431943007818 Int/Topo IB signature motif; other site 431943007819 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 431943007820 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 431943007821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 431943007822 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 431943007823 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 431943007824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943007825 ATP binding site [chemical binding]; other site 431943007826 putative Mg++ binding site [ion binding]; other site 431943007827 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 431943007828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943007829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943007830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943007831 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943007832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007833 S-adenosylmethionine binding site [chemical binding]; other site 431943007834 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943007835 FtsX-like permease family; Region: FtsX; pfam02687 431943007836 FtsX-like permease family; Region: FtsX; pfam02687 431943007837 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943007838 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 431943007839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943007840 Walker A/P-loop; other site 431943007841 ATP binding site [chemical binding]; other site 431943007842 Q-loop/lid; other site 431943007843 ABC transporter signature motif; other site 431943007844 Walker B; other site 431943007845 D-loop; other site 431943007846 H-loop/switch region; other site 431943007847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943007848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943007849 phosphorylation site [posttranslational modification] 431943007850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943007851 ATP binding site [chemical binding]; other site 431943007852 Mg2+ binding site [ion binding]; other site 431943007853 G-X-G motif; other site 431943007854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943007855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943007856 active site 431943007857 phosphorylation site [posttranslational modification] 431943007858 intermolecular recognition site; other site 431943007859 dimerization interface [polypeptide binding]; other site 431943007860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943007861 DNA binding site [nucleotide binding] 431943007862 aminoglycoside resistance protein; Provisional; Region: PRK13746 431943007863 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943007864 active site 431943007865 NTP binding site [chemical binding]; other site 431943007866 metal binding triad [ion binding]; metal-binding site 431943007867 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 431943007868 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 431943007869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943007870 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 431943007871 Coenzyme A binding pocket [chemical binding]; other site 431943007872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007873 S-adenosylmethionine binding site [chemical binding]; other site 431943007874 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943007875 active site 431943007876 NTP binding site [chemical binding]; other site 431943007877 metal binding triad [ion binding]; metal-binding site 431943007878 antibiotic binding site [chemical binding]; other site 431943007879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 431943007880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007881 ABC transporter; Region: ABC_tran_2; pfam12848 431943007882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 431943007883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943007884 H+ Antiporter protein; Region: 2A0121; TIGR00900 431943007885 putative substrate translocation pore; other site 431943007886 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943007887 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943007888 catalytic residues [active] 431943007889 catalytic nucleophile [active] 431943007890 Recombinase; Region: Recombinase; pfam07508 431943007891 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943007892 Recombinase; Region: Recombinase; pfam07508 431943007893 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943007894 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943007895 catalytic residues [active] 431943007896 catalytic nucleophile [active] 431943007897 Recombinase; Region: Recombinase; pfam07508 431943007898 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943007899 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 431943007900 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 431943007901 amidase catalytic site [active] 431943007902 Zn binding residues [ion binding]; other site 431943007903 substrate binding site [chemical binding]; other site 431943007904 Sporulation related domain; Region: SPOR; pfam05036 431943007905 Holin family; Region: Phage_holin_4; pfam05105 431943007906 Phage tail protein; Region: Sipho_tail; pfam05709 431943007907 Phage-related protein [Function unknown]; Region: COG5412 431943007908 membrane protein P6; Region: PHA01399 431943007909 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 431943007910 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 431943007911 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 431943007912 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 431943007913 oligomerization interface [polypeptide binding]; other site 431943007914 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 431943007915 Phage capsid family; Region: Phage_capsid; pfam05065 431943007916 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 431943007917 oligomer interface [polypeptide binding]; other site 431943007918 active site residues [active] 431943007919 Phage-related protein [Function unknown]; Region: COG4695 431943007920 Phage portal protein; Region: Phage_portal; pfam04860 431943007921 Phage Terminase; Region: Terminase_1; pfam03354 431943007922 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 431943007923 putative active site pocket [active] 431943007924 dimerization interface [polypeptide binding]; other site 431943007925 putative catalytic residue [active] 431943007926 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 431943007927 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 431943007928 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 431943007929 ParB-like nuclease domain; Region: ParB; smart00470 431943007930 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 431943007931 DNA methylase; Region: N6_N4_Mtase; pfam01555 431943007932 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 431943007933 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 431943007934 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 431943007935 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 431943007936 Phage terminase, small subunit; Region: Terminase_4; cl01525 431943007937 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 431943007938 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 431943007939 active site 431943007940 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 431943007941 active site 431943007942 catalytic residues [active] 431943007943 metal binding site [ion binding]; metal-binding site 431943007944 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 431943007945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943007946 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 431943007947 ATP binding site [chemical binding]; other site 431943007948 putative Mg++ binding site [ion binding]; other site 431943007949 VRR-NUC domain; Region: VRR_NUC; pfam08774 431943007950 Virulence-associated protein E; Region: VirE; pfam05272 431943007951 AntA/AntB antirepressor; Region: AntA; pfam08346 431943007952 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 431943007953 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 431943007954 active site 431943007955 DNA binding site [nucleotide binding] 431943007956 catalytic site [active] 431943007957 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 431943007958 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 431943007959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 431943007960 DNA binding residues [nucleotide binding] 431943007961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943007962 non-specific DNA binding site [nucleotide binding]; other site 431943007963 salt bridge; other site 431943007964 sequence-specific DNA binding site [nucleotide binding]; other site 431943007965 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 431943007966 non-specific DNA binding site [nucleotide binding]; other site 431943007967 salt bridge; other site 431943007968 sequence-specific DNA binding site [nucleotide binding]; other site 431943007969 Restriction endonuclease MspI; Region: Endonuc-MspI; pfam09208 431943007970 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 431943007971 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 431943007972 cofactor binding site; other site 431943007973 DNA binding site [nucleotide binding] 431943007974 substrate interaction site [chemical binding]; other site 431943007975 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 431943007976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943007977 S-adenosylmethionine binding site [chemical binding]; other site 431943007978 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 431943007979 Sulfatase; Region: Sulfatase; cl17466 431943007980 HTH-like domain; Region: HTH_21; pfam13276 431943007981 Integrase core domain; Region: rve; pfam00665 431943007982 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943007983 Integrase core domain; Region: rve_3; pfam13683 431943007984 Transposase; Region: HTH_Tnp_1; cl17663 431943007985 Sulfatase; Region: Sulfatase; cl17466 431943007986 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 431943007987 active site 431943007988 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 431943007989 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 431943007990 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 431943007991 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 431943007992 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 431943007993 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 431943007994 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 431943007995 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 431943007996 purine monophosphate binding site [chemical binding]; other site 431943007997 dimer interface [polypeptide binding]; other site 431943007998 putative catalytic residues [active] 431943007999 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 431943008000 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 431943008001 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 431943008002 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 431943008003 active site 431943008004 substrate binding site [chemical binding]; other site 431943008005 cosubstrate binding site; other site 431943008006 catalytic site [active] 431943008007 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 431943008008 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 431943008009 dimerization interface [polypeptide binding]; other site 431943008010 putative ATP binding site [chemical binding]; other site 431943008011 amidophosphoribosyltransferase; Provisional; Region: PRK05793 431943008012 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 431943008013 active site 431943008014 tetramer interface [polypeptide binding]; other site 431943008015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943008016 active site 431943008017 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 431943008018 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 431943008019 ATP binding site [chemical binding]; other site 431943008020 active site 431943008021 substrate binding site [chemical binding]; other site 431943008022 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 431943008023 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 431943008024 active site 431943008025 catalytic triad [active] 431943008026 oxyanion hole [active] 431943008027 Uncharacterized conserved protein [Function unknown]; Region: COG1434 431943008028 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 431943008029 putative active site [active] 431943008030 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 431943008031 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 431943008032 Methyltransferase domain; Region: Methyltransf_26; pfam13659 431943008033 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 431943008034 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 431943008035 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 431943008036 Trypsin; Region: Trypsin; pfam00089 431943008037 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 431943008038 protein binding site [polypeptide binding]; other site 431943008039 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 431943008040 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 431943008041 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 431943008042 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 431943008043 active site 431943008044 substrate-binding site [chemical binding]; other site 431943008045 metal-binding site [ion binding] 431943008046 ATP binding site [chemical binding]; other site 431943008047 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 431943008048 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943008049 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 431943008050 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 431943008051 catalytic triad [active] 431943008052 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 431943008053 Clp amino terminal domain; Region: Clp_N; pfam02861 431943008054 Clp amino terminal domain; Region: Clp_N; pfam02861 431943008055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943008056 Walker A motif; other site 431943008057 ATP binding site [chemical binding]; other site 431943008058 Walker B motif; other site 431943008059 arginine finger; other site 431943008060 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 431943008061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943008062 Walker A motif; other site 431943008063 ATP binding site [chemical binding]; other site 431943008064 Walker B motif; other site 431943008065 arginine finger; other site 431943008066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 431943008067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943008068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008069 non-specific DNA binding site [nucleotide binding]; other site 431943008070 salt bridge; other site 431943008071 sequence-specific DNA binding site [nucleotide binding]; other site 431943008072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008073 non-specific DNA binding site [nucleotide binding]; other site 431943008074 salt bridge; other site 431943008075 sequence-specific DNA binding site [nucleotide binding]; other site 431943008076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943008077 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943008078 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 431943008079 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 431943008080 Predicted membrane protein [Function unknown]; Region: COG2364 431943008081 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 431943008082 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 431943008083 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 431943008084 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943008085 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 431943008087 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 431943008088 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943008089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943008090 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 431943008091 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 431943008092 Soluble P-type ATPase [General function prediction only]; Region: COG4087 431943008093 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 431943008094 putative homodimer interface [polypeptide binding]; other site 431943008095 putative homotetramer interface [polypeptide binding]; other site 431943008096 putative metal binding site [ion binding]; other site 431943008097 putative homodimer-homodimer interface [polypeptide binding]; other site 431943008098 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 431943008099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943008100 Walker A motif; other site 431943008101 ATP binding site [chemical binding]; other site 431943008102 Walker B motif; other site 431943008103 arginine finger; other site 431943008104 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 431943008105 active site 431943008106 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 431943008107 Rhomboid family; Region: Rhomboid; pfam01694 431943008108 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 431943008109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943008110 Zn2+ binding site [ion binding]; other site 431943008111 Mg2+ binding site [ion binding]; other site 431943008112 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943008113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943008114 metal binding site 2 [ion binding]; metal-binding site 431943008115 putative DNA binding helix; other site 431943008116 metal binding site 1 [ion binding]; metal-binding site 431943008117 dimer interface [polypeptide binding]; other site 431943008118 structural Zn2+ binding site [ion binding]; other site 431943008119 Predicted membrane protein [Function unknown]; Region: COG1971 431943008120 Protein of unknown function DUF45; Region: DUF45; pfam01863 431943008121 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 431943008122 C-terminal peptidase (prc); Region: prc; TIGR00225 431943008123 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 431943008124 protein binding site [polypeptide binding]; other site 431943008125 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 431943008126 Catalytic dyad [active] 431943008127 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943008128 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008129 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008130 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008131 MarR family; Region: MarR; pfam01047 431943008132 MarR family; Region: MarR_2; cl17246 431943008133 Isochorismatase family; Region: Isochorismatase; pfam00857 431943008134 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 431943008135 catalytic triad [active] 431943008136 conserved cis-peptide bond; other site 431943008137 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 431943008138 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 431943008139 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943008140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 431943008141 Cache domain; Region: Cache_1; pfam02743 431943008142 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 431943008143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943008144 dimerization interface [polypeptide binding]; other site 431943008145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008146 dimer interface [polypeptide binding]; other site 431943008147 putative CheW interface [polypeptide binding]; other site 431943008148 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 431943008149 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 431943008150 tetramer interface [polypeptide binding]; other site 431943008151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943008152 catalytic residue [active] 431943008153 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 431943008154 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 431943008155 putative catalytic cysteine [active] 431943008156 gamma-glutamyl kinase; Provisional; Region: PRK05429 431943008157 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 431943008158 nucleotide binding site [chemical binding]; other site 431943008159 homotetrameric interface [polypeptide binding]; other site 431943008160 putative phosphate binding site [ion binding]; other site 431943008161 putative allosteric binding site; other site 431943008162 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 431943008163 pyrroline-5-carboxylate reductase; Region: PLN02688 431943008164 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 431943008165 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 431943008166 Cl- selectivity filter; other site 431943008167 Cl- binding residues [ion binding]; other site 431943008168 pore gating glutamate residue; other site 431943008169 dimer interface [polypeptide binding]; other site 431943008170 H+/Cl- coupling transport residue; other site 431943008171 TrkA-C domain; Region: TrkA_C; pfam02080 431943008172 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 431943008173 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 431943008174 putative ligand binding site [chemical binding]; other site 431943008175 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 431943008176 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 431943008177 Walker A/P-loop; other site 431943008178 ATP binding site [chemical binding]; other site 431943008179 Q-loop/lid; other site 431943008180 ABC transporter signature motif; other site 431943008181 Walker B; other site 431943008182 D-loop; other site 431943008183 H-loop/switch region; other site 431943008184 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 431943008185 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 431943008186 Walker A/P-loop; other site 431943008187 ATP binding site [chemical binding]; other site 431943008188 Q-loop/lid; other site 431943008189 ABC transporter signature motif; other site 431943008190 Walker B; other site 431943008191 D-loop; other site 431943008192 H-loop/switch region; other site 431943008193 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 431943008194 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 431943008195 TM-ABC transporter signature motif; other site 431943008196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 431943008197 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 431943008198 TM-ABC transporter signature motif; other site 431943008199 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 431943008200 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 431943008201 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 431943008202 active site 431943008203 catalytic residues [active] 431943008204 metal binding site [ion binding]; metal-binding site 431943008205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008206 non-specific DNA binding site [nucleotide binding]; other site 431943008207 salt bridge; other site 431943008208 sequence-specific DNA binding site [nucleotide binding]; other site 431943008209 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 431943008210 active site 431943008211 oxyanion hole [active] 431943008212 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943008213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 431943008214 Transposase; Region: HTH_Tnp_1; cl17663 431943008215 HTH-like domain; Region: HTH_21; pfam13276 431943008216 Integrase core domain; Region: rve; pfam00665 431943008217 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943008218 Integrase core domain; Region: rve_3; pfam13683 431943008219 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 431943008220 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 431943008221 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 431943008222 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 431943008223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 431943008224 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 431943008225 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 431943008226 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 431943008227 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 431943008228 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 431943008229 Divergent AAA domain; Region: AAA_4; pfam04326 431943008230 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 431943008231 Predicted permeases [General function prediction only]; Region: RarD; COG2962 431943008232 EamA-like transporter family; Region: EamA; cl17759 431943008233 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 431943008234 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 431943008235 DNA binding residues [nucleotide binding] 431943008236 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 431943008237 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943008238 Spore germination protein; Region: Spore_permease; cl17796 431943008239 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 431943008240 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 431943008241 Lamin Tail Domain; Region: LTD; pfam00932 431943008242 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 431943008243 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 431943008244 ADP-ribose binding site [chemical binding]; other site 431943008245 Superoxide dismutase [Fe]; Provisional; Region: PTZ00078 431943008246 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 431943008247 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 431943008248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008249 putative PBP binding loops; other site 431943008250 dimer interface [polypeptide binding]; other site 431943008251 ABC-ATPase subunit interface; other site 431943008252 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 431943008253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008254 dimer interface [polypeptide binding]; other site 431943008255 conserved gate region; other site 431943008256 putative PBP binding loops; other site 431943008257 ABC-ATPase subunit interface; other site 431943008258 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 431943008259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 431943008260 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 431943008261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943008262 Walker A/P-loop; other site 431943008263 ATP binding site [chemical binding]; other site 431943008264 Q-loop/lid; other site 431943008265 ABC transporter signature motif; other site 431943008266 Walker B; other site 431943008267 D-loop; other site 431943008268 H-loop/switch region; other site 431943008269 TOBE domain; Region: TOBE_2; pfam08402 431943008270 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 431943008271 intersubunit interface [polypeptide binding]; other site 431943008272 active site 431943008273 catalytic residue [active] 431943008274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 431943008275 NMT1/THI5 like; Region: NMT1; pfam09084 431943008276 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943008277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008278 dimer interface [polypeptide binding]; other site 431943008279 conserved gate region; other site 431943008280 putative PBP binding loops; other site 431943008281 ABC-ATPase subunit interface; other site 431943008282 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008283 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008284 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 431943008285 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008286 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008287 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008288 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 431943008289 Cache domain; Region: Cache_1; pfam02743 431943008290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943008291 dimerization interface [polypeptide binding]; other site 431943008292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943008293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008294 dimer interface [polypeptide binding]; other site 431943008295 putative CheW interface [polypeptide binding]; other site 431943008296 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 431943008297 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 431943008298 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 431943008299 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 431943008300 putative active site [active] 431943008301 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 431943008302 active site 431943008303 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 431943008304 Rubredoxin [Energy production and conversion]; Region: COG1773 431943008305 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 431943008306 iron binding site [ion binding]; other site 431943008307 Integral membrane protein TerC family; Region: TerC; cl10468 431943008308 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 431943008309 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 431943008310 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 431943008311 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 431943008312 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943008313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008314 dimer interface [polypeptide binding]; other site 431943008315 conserved gate region; other site 431943008316 putative PBP binding loops; other site 431943008317 ABC-ATPase subunit interface; other site 431943008318 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 431943008319 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 431943008320 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 431943008321 Walker A/P-loop; other site 431943008322 ATP binding site [chemical binding]; other site 431943008323 Q-loop/lid; other site 431943008324 ABC transporter signature motif; other site 431943008325 Walker B; other site 431943008326 D-loop; other site 431943008327 H-loop/switch region; other site 431943008328 FOG: CBS domain [General function prediction only]; Region: COG0517 431943008329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 431943008330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 431943008331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943008332 DNA-binding site [nucleotide binding]; DNA binding site 431943008333 TrkA-C domain; Region: TrkA_C; pfam02080 431943008334 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 431943008335 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 431943008336 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 431943008337 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 431943008338 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 431943008339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943008340 active site 431943008341 phosphorylation site [posttranslational modification] 431943008342 intermolecular recognition site; other site 431943008343 dimerization interface [polypeptide binding]; other site 431943008344 LytTr DNA-binding domain; Region: LytTR; smart00850 431943008345 hypothetical protein; Provisional; Region: PRK11479 431943008346 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 431943008347 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 431943008348 Histidine kinase; Region: His_kinase; pfam06580 431943008349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943008350 ATP binding site [chemical binding]; other site 431943008351 Mg2+ binding site [ion binding]; other site 431943008352 G-X-G motif; other site 431943008353 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 431943008354 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 431943008355 putative dimer interface [polypeptide binding]; other site 431943008356 MutS domain III; Region: MutS_III; cl17822 431943008357 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 431943008358 Walker A/P-loop; other site 431943008359 ATP binding site [chemical binding]; other site 431943008360 Q-loop/lid; other site 431943008361 ABC transporter signature motif; other site 431943008362 Walker B; other site 431943008363 D-loop; other site 431943008364 H-loop/switch region; other site 431943008365 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 431943008366 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 431943008367 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 431943008368 RNA/DNA hybrid binding site [nucleotide binding]; other site 431943008369 active site 431943008370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943008371 S-adenosylmethionine binding site [chemical binding]; other site 431943008372 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 431943008373 Peptidase family M50; Region: Peptidase_M50; pfam02163 431943008374 active site 431943008375 putative substrate binding region [chemical binding]; other site 431943008376 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 431943008377 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 431943008378 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 431943008379 putative active site [active] 431943008380 PhoH-like protein; Region: PhoH; pfam02562 431943008381 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943008382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943008383 Walker A/P-loop; other site 431943008384 ATP binding site [chemical binding]; other site 431943008385 Q-loop/lid; other site 431943008386 ABC transporter signature motif; other site 431943008387 Walker B; other site 431943008388 D-loop; other site 431943008389 H-loop/switch region; other site 431943008390 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943008391 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943008392 Protein of unknown function (DUF554); Region: DUF554; pfam04474 431943008393 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943008394 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943008395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008396 dimer interface [polypeptide binding]; other site 431943008397 putative CheW interface [polypeptide binding]; other site 431943008398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 431943008399 I-site; other site 431943008400 active site 431943008401 metal binding site [ion binding]; metal-binding site 431943008402 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943008403 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 431943008404 AzlC protein; Region: AzlC; cl00570 431943008405 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 431943008406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008407 non-specific DNA binding site [nucleotide binding]; other site 431943008408 salt bridge; other site 431943008409 sequence-specific DNA binding site [nucleotide binding]; other site 431943008410 Cupin domain; Region: Cupin_2; pfam07883 431943008411 flavodoxin; Provisional; Region: PRK06242 431943008412 Flavin Reductases; Region: FlaRed; cl00801 431943008413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008414 sequence-specific DNA binding site [nucleotide binding]; other site 431943008415 salt bridge; other site 431943008416 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 431943008417 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 431943008418 active site 431943008419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943008420 Tetratricopeptide repeat; Region: TPR_16; pfam13432 431943008421 A short protein domain of unknown function; Region: IDEAL; smart00914 431943008422 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 431943008423 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 431943008424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943008425 S-adenosylmethionine binding site [chemical binding]; other site 431943008426 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 431943008427 Domain of unknown function DUF21; Region: DUF21; pfam01595 431943008428 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 431943008429 Transporter associated domain; Region: CorC_HlyC; pfam03471 431943008430 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943008431 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 431943008432 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 431943008433 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 431943008434 active site 431943008435 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 431943008436 Predicted membrane protein [Function unknown]; Region: COG3212 431943008437 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943008438 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943008439 Spore germination protein; Region: Spore_permease; cl17796 431943008440 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943008441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943008442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943008443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943008444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943008445 putative substrate translocation pore; other site 431943008446 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 431943008447 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 431943008448 Catalytic site [active] 431943008449 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 431943008450 active site 1 [active] 431943008451 dimer interface [polypeptide binding]; other site 431943008452 hexamer interface [polypeptide binding]; other site 431943008453 active site 2 [active] 431943008454 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 431943008455 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 431943008456 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943008457 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943008458 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 431943008459 catalytic residues [active] 431943008460 catalytic nucleophile [active] 431943008461 Presynaptic Site I dimer interface [polypeptide binding]; other site 431943008462 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 431943008463 Synaptic Flat tetramer interface [polypeptide binding]; other site 431943008464 Synaptic Site I dimer interface [polypeptide binding]; other site 431943008465 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 431943008466 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 431943008467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008468 non-specific DNA binding site [nucleotide binding]; other site 431943008469 salt bridge; other site 431943008470 sequence-specific DNA binding site [nucleotide binding]; other site 431943008471 hypothetical protein; Provisional; Region: PRK06771 431943008472 Transposase IS200 like; Region: Y1_Tnp; pfam01797 431943008473 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943008474 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943008475 catalytic residues [active] 431943008476 Recombinase; Region: Recombinase; pfam07508 431943008477 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943008478 HTH-like domain; Region: HTH_21; pfam13276 431943008479 Integrase core domain; Region: rve; pfam00665 431943008480 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 431943008481 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 431943008482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943008483 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 431943008484 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 431943008485 sequence-specific DNA binding site [nucleotide binding]; other site 431943008486 salt bridge; other site 431943008487 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008488 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008489 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008490 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 431943008491 dimer interface [polypeptide binding]; other site 431943008492 catalytic triad [active] 431943008493 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 431943008494 DNA-binding site [nucleotide binding]; DNA binding site 431943008495 RNA-binding motif; other site 431943008496 MarR family; Region: MarR_2; cl17246 431943008497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943008498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943008499 putative substrate translocation pore; other site 431943008500 FOG: CBS domain [General function prediction only]; Region: COG0517 431943008501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 431943008502 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 431943008503 active site 431943008504 Cu2+ binding site [ion binding]; other site 431943008505 E-class dimer interface [polypeptide binding]; other site 431943008506 Zn2+ binding site [ion binding]; other site 431943008507 P-class dimer interface [polypeptide binding]; other site 431943008508 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943008509 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943008510 Serine hydrolase; Region: Ser_hydrolase; cl17834 431943008511 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 431943008512 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 431943008513 hypothetical protein; Provisional; Region: PRK06771 431943008514 Phage terminase small subunit; Region: Phage_terminase; pfam10668 431943008515 Terminase small subunit; Region: Terminase_2; pfam03592 431943008516 beta-lactamase TEM; Provisional; Region: PRK15442 431943008517 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 431943008518 Integrase core domain; Region: rve; pfam00665 431943008519 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 431943008520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943008521 Walker A/P-loop; other site 431943008522 ATP binding site [chemical binding]; other site 431943008523 Q-loop/lid; other site 431943008524 ABC transporter signature motif; other site 431943008525 Walker B; other site 431943008526 D-loop; other site 431943008527 H-loop/switch region; other site 431943008528 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 431943008529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 431943008530 ABC-ATPase subunit interface; other site 431943008531 dimer interface [polypeptide binding]; other site 431943008532 putative PBP binding regions; other site 431943008533 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 431943008534 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 431943008535 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 431943008536 putative dimer interface [polypeptide binding]; other site 431943008537 active site pocket [active] 431943008538 putative cataytic base [active] 431943008539 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 431943008540 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 431943008541 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 431943008542 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 431943008543 dimer interface [polypeptide binding]; other site 431943008544 active site 431943008545 ADP-ribose binding site [chemical binding]; other site 431943008546 nudix motif; other site 431943008547 metal binding site [ion binding]; metal-binding site 431943008548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943008549 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 431943008550 DNA-binding site [nucleotide binding]; DNA binding site 431943008551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943008552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943008553 homodimer interface [polypeptide binding]; other site 431943008554 catalytic residue [active] 431943008555 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 431943008556 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 431943008557 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 431943008558 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 431943008559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 431943008560 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 431943008561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943008562 Beta-Casp domain; Region: Beta-Casp; smart01027 431943008563 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 431943008564 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 431943008565 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 431943008566 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 431943008567 thiamine phosphate binding site [chemical binding]; other site 431943008568 active site 431943008569 pyrophosphate binding site [ion binding]; other site 431943008570 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 431943008571 substrate binding site [chemical binding]; other site 431943008572 multimerization interface [polypeptide binding]; other site 431943008573 ATP binding site [chemical binding]; other site 431943008574 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 431943008575 dimer interface [polypeptide binding]; other site 431943008576 substrate binding site [chemical binding]; other site 431943008577 ATP binding site [chemical binding]; other site 431943008578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943008579 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 431943008580 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 431943008581 Int/Topo IB signature motif; other site 431943008582 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943008583 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 431943008584 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 431943008585 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 431943008586 Double zinc ribbon; Region: DZR; pfam12773 431943008587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943008588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008589 sequence-specific DNA binding site [nucleotide binding]; other site 431943008590 salt bridge; other site 431943008591 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 431943008592 Domain of unknown function (DUF932); Region: DUF932; pfam06067 431943008593 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008594 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008595 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008596 Tetratricopeptide repeat; Region: TPR_16; pfam13432 431943008597 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 431943008598 Transposase; Region: HTH_Tnp_1; cl17663 431943008599 HTH-like domain; Region: HTH_21; pfam13276 431943008600 Integrase core domain; Region: rve; pfam00665 431943008601 DDE domain; Region: DDE_Tnp_IS240; pfam13610 431943008602 Integrase core domain; Region: rve_3; pfam13683 431943008603 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 431943008604 Methyltransferase domain; Region: Methyltransf_26; pfam13659 431943008605 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 431943008606 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 431943008607 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 431943008608 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 431943008609 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 431943008610 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 431943008611 Int/Topo IB signature motif; other site 431943008612 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 431943008613 putative active site [active] 431943008614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008615 non-specific DNA binding site [nucleotide binding]; other site 431943008616 salt bridge; other site 431943008617 sequence-specific DNA binding site [nucleotide binding]; other site 431943008618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008619 non-specific DNA binding site [nucleotide binding]; other site 431943008620 salt bridge; other site 431943008621 sequence-specific DNA binding site [nucleotide binding]; other site 431943008622 Helix-turn-helix domain; Region: HTH_17; cl17695 431943008623 Uncharacterized conserved protein [Function unknown]; Region: COG4983 431943008624 D5 N terminal like; Region: D5_N; smart00885 431943008625 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 431943008626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008627 non-specific DNA binding site [nucleotide binding]; other site 431943008628 salt bridge; other site 431943008629 sequence-specific DNA binding site [nucleotide binding]; other site 431943008630 Helix-turn-helix domain; Region: HTH_17; cl17695 431943008631 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 431943008632 Phage capsid family; Region: Phage_capsid; pfam05065 431943008633 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 431943008634 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943008635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943008636 DNA binding residues [nucleotide binding] 431943008637 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 431943008638 DNA-binding site [nucleotide binding]; DNA binding site 431943008639 RNA-binding motif; other site 431943008640 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 431943008641 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943008642 dimer interface [polypeptide binding]; other site 431943008643 active site 431943008644 metal binding site [ion binding]; metal-binding site 431943008645 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 431943008646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943008647 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943008648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943008649 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943008650 4Fe-4S binding domain; Region: Fer4_5; pfam12801 431943008651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943008652 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943008653 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943008654 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 431943008655 dimer interface [polypeptide binding]; other site 431943008656 active site 431943008657 metal binding site [ion binding]; metal-binding site 431943008658 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 431943008659 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 431943008660 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 431943008661 putative active site [active] 431943008662 putative NTP binding site [chemical binding]; other site 431943008663 putative nucleic acid binding site [nucleotide binding]; other site 431943008664 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 431943008665 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 431943008666 diiron binding motif [ion binding]; other site 431943008667 maltose O-acetyltransferase; Provisional; Region: PRK10092 431943008668 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 431943008669 active site 431943008670 substrate binding site [chemical binding]; other site 431943008671 trimer interface [polypeptide binding]; other site 431943008672 CoA binding site [chemical binding]; other site 431943008673 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943008674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943008675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943008676 MarR family; Region: MarR_2; pfam12802 431943008677 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 431943008678 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 431943008679 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 431943008680 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 431943008681 TPP-binding site [chemical binding]; other site 431943008682 putative dimer interface [polypeptide binding]; other site 431943008683 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 431943008684 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 431943008685 dimer interface [polypeptide binding]; other site 431943008686 PYR/PP interface [polypeptide binding]; other site 431943008687 TPP binding site [chemical binding]; other site 431943008688 substrate binding site [chemical binding]; other site 431943008689 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 431943008690 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 431943008691 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 431943008692 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 431943008693 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943008694 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 431943008695 dimer interface [polypeptide binding]; other site 431943008696 active site 431943008697 metal binding site [ion binding]; metal-binding site 431943008698 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 431943008699 4Fe-4S binding domain; Region: Fer4_6; pfam12837 431943008700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943008701 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 431943008702 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 431943008703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943008704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943008705 non-specific DNA binding site [nucleotide binding]; other site 431943008706 salt bridge; other site 431943008707 sequence-specific DNA binding site [nucleotide binding]; other site 431943008708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943008709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943008710 dimer interface [polypeptide binding]; other site 431943008711 phosphorylation site [posttranslational modification] 431943008712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943008713 ATP binding site [chemical binding]; other site 431943008714 Mg2+ binding site [ion binding]; other site 431943008715 G-X-G motif; other site 431943008716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943008717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943008718 active site 431943008719 phosphorylation site [posttranslational modification] 431943008720 intermolecular recognition site; other site 431943008721 dimerization interface [polypeptide binding]; other site 431943008722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943008723 DNA binding site [nucleotide binding] 431943008724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943008725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008726 dimer interface [polypeptide binding]; other site 431943008727 putative CheW interface [polypeptide binding]; other site 431943008728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943008729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 431943008730 NAD(P) binding site [chemical binding]; other site 431943008731 active site 431943008732 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943008733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943008734 Walker A/P-loop; other site 431943008735 ATP binding site [chemical binding]; other site 431943008736 Q-loop/lid; other site 431943008737 ABC transporter signature motif; other site 431943008738 Walker B; other site 431943008739 D-loop; other site 431943008740 H-loop/switch region; other site 431943008741 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 431943008742 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 431943008743 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 431943008744 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 431943008745 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 431943008746 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 431943008747 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943008748 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 431943008749 active site 431943008750 NAD binding site [chemical binding]; other site 431943008751 metal binding site [ion binding]; metal-binding site 431943008752 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 431943008753 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 431943008754 putative catalytic cysteine [active] 431943008755 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 431943008756 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 431943008757 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 431943008758 EamA-like transporter family; Region: EamA; pfam00892 431943008759 EamA-like transporter family; Region: EamA; pfam00892 431943008760 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 431943008761 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 431943008762 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 431943008763 NifU-like domain; Region: NifU; cl00484 431943008764 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 431943008765 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 431943008766 PAS domain S-box; Region: sensory_box; TIGR00229 431943008767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943008768 putative active site [active] 431943008769 heme pocket [chemical binding]; other site 431943008770 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 431943008771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943008772 Walker A motif; other site 431943008773 ATP binding site [chemical binding]; other site 431943008774 Walker B motif; other site 431943008775 arginine finger; other site 431943008776 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 431943008777 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 431943008778 dimer interaction site [polypeptide binding]; other site 431943008779 substrate-binding tunnel; other site 431943008780 active site 431943008781 catalytic site [active] 431943008782 substrate binding site [chemical binding]; other site 431943008783 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 431943008784 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 431943008785 putative catalytic cysteine [active] 431943008786 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 431943008787 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 431943008788 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 431943008789 acyl-activating enzyme (AAE) consensus motif; other site 431943008790 putative AMP binding site [chemical binding]; other site 431943008791 putative active site [active] 431943008792 putative CoA binding site [chemical binding]; other site 431943008793 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 431943008794 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 431943008795 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 431943008796 polypeptide substrate binding site [polypeptide binding]; other site 431943008797 active site 431943008798 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 431943008799 Bacterial PH domain; Region: DUF304; cl01348 431943008800 Predicted membrane protein [Function unknown]; Region: COG3428 431943008801 Bacterial PH domain; Region: DUF304; pfam03703 431943008802 Bacterial PH domain; Region: DUF304; pfam03703 431943008803 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 431943008804 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943008805 Recombinase; Region: Recombinase; pfam07508 431943008806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943008807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943008809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 431943008810 putative substrate translocation pore; other site 431943008811 FtsX-like permease family; Region: FtsX; pfam02687 431943008812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943008813 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943008814 FtsX-like permease family; Region: FtsX; pfam02687 431943008815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943008816 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943008817 Walker A/P-loop; other site 431943008818 ATP binding site [chemical binding]; other site 431943008819 Q-loop/lid; other site 431943008820 ABC transporter signature motif; other site 431943008821 Walker B; other site 431943008822 D-loop; other site 431943008823 H-loop/switch region; other site 431943008824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943008825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943008826 dimer interface [polypeptide binding]; other site 431943008827 phosphorylation site [posttranslational modification] 431943008828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943008829 ATP binding site [chemical binding]; other site 431943008830 Mg2+ binding site [ion binding]; other site 431943008831 G-X-G motif; other site 431943008832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943008833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943008834 active site 431943008835 phosphorylation site [posttranslational modification] 431943008836 intermolecular recognition site; other site 431943008837 dimerization interface [polypeptide binding]; other site 431943008838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943008839 DNA binding site [nucleotide binding] 431943008840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943008841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943008842 dimer interface [polypeptide binding]; other site 431943008843 phosphorylation site [posttranslational modification] 431943008844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943008845 ATP binding site [chemical binding]; other site 431943008846 Mg2+ binding site [ion binding]; other site 431943008847 G-X-G motif; other site 431943008848 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943008849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943008850 active site 431943008851 phosphorylation site [posttranslational modification] 431943008852 intermolecular recognition site; other site 431943008853 dimerization interface [polypeptide binding]; other site 431943008854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943008855 DNA binding site [nucleotide binding] 431943008856 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943008857 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 431943008858 Walker A/P-loop; other site 431943008859 ATP binding site [chemical binding]; other site 431943008860 Q-loop/lid; other site 431943008861 ABC transporter signature motif; other site 431943008862 Walker B; other site 431943008863 D-loop; other site 431943008864 H-loop/switch region; other site 431943008865 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943008866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 431943008867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 431943008868 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943008869 glutamate dehydrogenase; Provisional; Region: PRK09414 431943008870 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 431943008871 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 431943008872 NAD(P) binding site [chemical binding]; other site 431943008873 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 431943008874 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 431943008875 metal binding site [ion binding]; metal-binding site 431943008876 YibE/F-like protein; Region: YibE_F; pfam07907 431943008877 Cache domain; Region: Cache_1; pfam02743 431943008878 HAMP domain; Region: HAMP; pfam00672 431943008879 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943008880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008881 dimer interface [polypeptide binding]; other site 431943008882 putative CheW interface [polypeptide binding]; other site 431943008883 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 431943008884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943008885 Walker A/P-loop; other site 431943008886 ATP binding site [chemical binding]; other site 431943008887 Q-loop/lid; other site 431943008888 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 431943008889 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 431943008890 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 431943008891 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 431943008892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 431943008893 membrane-bound complex binding site; other site 431943008894 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943008895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008896 dimer interface [polypeptide binding]; other site 431943008897 conserved gate region; other site 431943008898 putative PBP binding loops; other site 431943008899 ABC-ATPase subunit interface; other site 431943008900 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 431943008901 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 431943008902 Walker A/P-loop; other site 431943008903 ATP binding site [chemical binding]; other site 431943008904 Q-loop/lid; other site 431943008905 ABC transporter signature motif; other site 431943008906 Walker B; other site 431943008907 D-loop; other site 431943008908 H-loop/switch region; other site 431943008909 putative oxidoreductase; Provisional; Region: PRK08275 431943008910 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 431943008911 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 431943008912 Ferredoxin [Energy production and conversion]; Region: COG1146 431943008913 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 431943008914 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 431943008915 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 431943008916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943008917 catalytic residue [active] 431943008918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943008919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943008920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 431943008921 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 431943008922 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 431943008923 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 431943008924 Outer membrane efflux protein; Region: OEP; pfam02321 431943008925 Outer membrane efflux protein; Region: OEP; pfam02321 431943008926 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 431943008927 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008928 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008929 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008930 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008931 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008932 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008933 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008934 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943008935 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 431943008936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943008937 FeS/SAM binding site; other site 431943008938 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 431943008939 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 431943008940 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 431943008941 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008942 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943008943 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943008944 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 431943008945 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 431943008946 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943008947 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 431943008948 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943008949 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 431943008950 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 431943008951 Nucleotide-binding sites [chemical binding]; other site 431943008952 Walker A motif; other site 431943008953 Switch I region of nucleotide binding site; other site 431943008954 Fe4S4 binding sites [ion binding]; other site 431943008955 Switch II region of nucleotide binding site; other site 431943008956 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943008957 PBP superfamily domain; Region: PBP_like; pfam12727 431943008958 molybdenum-pterin binding domain; Region: Mop; TIGR00638 431943008959 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 431943008960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943008961 Walker A/P-loop; other site 431943008962 ATP binding site [chemical binding]; other site 431943008963 Q-loop/lid; other site 431943008964 ABC transporter signature motif; other site 431943008965 Walker B; other site 431943008966 D-loop; other site 431943008967 H-loop/switch region; other site 431943008968 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 431943008969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943008970 dimer interface [polypeptide binding]; other site 431943008971 conserved gate region; other site 431943008972 putative PBP binding loops; other site 431943008973 ABC-ATPase subunit interface; other site 431943008974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 431943008975 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 431943008976 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 431943008977 trimer interface [polypeptide binding]; other site 431943008978 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943008979 Sensory domain found in PocR; Region: PocR; pfam10114 431943008980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943008981 putative CheW interface [polypeptide binding]; other site 431943008982 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 431943008983 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 431943008984 Probable transposase; Region: OrfB_IS605; pfam01385 431943008985 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 431943008986 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 431943008987 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 431943008988 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943008989 Transposase [DNA replication, recombination, and repair]; Region: COG5421 431943008990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 431943008991 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 431943008992 active site 431943008993 DNA binding site [nucleotide binding] 431943008994 Int/Topo IB signature motif; other site 431943008995 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 431943008996 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 431943008997 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008998 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943008999 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943009000 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943009001 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943009002 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943009003 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 431943009004 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 431943009005 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 431943009006 Ligand Binding Site [chemical binding]; other site 431943009007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943009008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943009009 dimer interface [polypeptide binding]; other site 431943009010 phosphorylation site [posttranslational modification] 431943009011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009012 ATP binding site [chemical binding]; other site 431943009013 Mg2+ binding site [ion binding]; other site 431943009014 G-X-G motif; other site 431943009015 Accessory gene regulator B; Region: AgrB; pfam04647 431943009016 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 431943009017 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 431943009018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943009019 putative active site [active] 431943009020 heme pocket [chemical binding]; other site 431943009021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943009022 dimer interface [polypeptide binding]; other site 431943009023 phosphorylation site [posttranslational modification] 431943009024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009025 ATP binding site [chemical binding]; other site 431943009026 Mg2+ binding site [ion binding]; other site 431943009027 G-X-G motif; other site 431943009028 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943009029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943009030 dimerization interface [polypeptide binding]; other site 431943009031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943009032 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943009033 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943009034 dimer interface [polypeptide binding]; other site 431943009035 putative CheW interface [polypeptide binding]; other site 431943009036 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 431943009037 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 431943009038 inhibitor-cofactor binding pocket; inhibition site 431943009039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943009040 catalytic residue [active] 431943009041 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 431943009042 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 431943009043 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 431943009044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 431943009045 active site 431943009046 ATP binding site [chemical binding]; other site 431943009047 Haemolysin-III related; Region: HlyIII; cl03831 431943009048 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 431943009049 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943009050 EamA-like transporter family; Region: EamA; pfam00892 431943009051 EamA-like transporter family; Region: EamA; pfam00892 431943009052 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 431943009053 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 431943009054 dimer interface [polypeptide binding]; other site 431943009055 anticodon binding site; other site 431943009056 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 431943009057 homodimer interface [polypeptide binding]; other site 431943009058 motif 1; other site 431943009059 active site 431943009060 motif 2; other site 431943009061 GAD domain; Region: GAD; pfam02938 431943009062 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 431943009063 motif 3; other site 431943009064 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 431943009065 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 431943009066 dimer interface [polypeptide binding]; other site 431943009067 motif 1; other site 431943009068 active site 431943009069 motif 2; other site 431943009070 motif 3; other site 431943009071 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 431943009072 anticodon binding site; other site 431943009073 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 431943009074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943009075 FeS/SAM binding site; other site 431943009076 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 431943009077 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 431943009078 putative active site [active] 431943009079 dimerization interface [polypeptide binding]; other site 431943009080 putative tRNAtyr binding site [nucleotide binding]; other site 431943009081 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 431943009082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943009083 Zn2+ binding site [ion binding]; other site 431943009084 Mg2+ binding site [ion binding]; other site 431943009085 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 431943009086 synthetase active site [active] 431943009087 NTP binding site [chemical binding]; other site 431943009088 metal binding site [ion binding]; metal-binding site 431943009089 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 431943009090 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 431943009091 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943009092 active site 431943009093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 431943009094 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 431943009095 Probable transposase; Region: OrfB_IS605; pfam01385 431943009096 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943009097 catalytic residues [active] 431943009098 DHH family; Region: DHH; pfam01368 431943009099 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 431943009100 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 431943009101 Protein export membrane protein; Region: SecD_SecF; cl14618 431943009102 protein-export membrane protein SecD; Region: secD; TIGR01129 431943009103 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 431943009104 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 431943009105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943009106 FeS/SAM binding site; other site 431943009107 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 431943009108 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 431943009109 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 431943009110 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 431943009111 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 431943009112 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 431943009113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 431943009114 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 431943009115 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 431943009116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943009117 Walker A motif; other site 431943009118 ATP binding site [chemical binding]; other site 431943009119 Walker B motif; other site 431943009120 arginine finger; other site 431943009121 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 431943009122 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 431943009123 RuvA N terminal domain; Region: RuvA_N; pfam01330 431943009124 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 431943009125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943009126 hypothetical protein; Validated; Region: PRK00110 431943009127 Uncharacterized conserved protein [Function unknown]; Region: COG1739 431943009128 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 431943009129 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 431943009130 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 431943009131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943009132 DNA-binding site [nucleotide binding]; DNA binding site 431943009133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943009134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943009135 homodimer interface [polypeptide binding]; other site 431943009136 catalytic residue [active] 431943009137 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 431943009138 active site 431943009139 NTP binding site [chemical binding]; other site 431943009140 metal binding triad [ion binding]; metal-binding site 431943009141 antibiotic binding site [chemical binding]; other site 431943009142 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 431943009143 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 431943009144 HflX GTPase family; Region: HflX; cd01878 431943009145 G1 box; other site 431943009146 GTP/Mg2+ binding site [chemical binding]; other site 431943009147 Switch I region; other site 431943009148 G2 box; other site 431943009149 G3 box; other site 431943009150 Switch II region; other site 431943009151 G4 box; other site 431943009152 G5 box; other site 431943009153 Transglycosylase; Region: Transgly; pfam00912 431943009154 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 431943009155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 431943009156 sporulation sigma factor SigF; Validated; Region: PRK05572 431943009157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 431943009158 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 431943009159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943009160 DNA binding residues [nucleotide binding] 431943009161 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 431943009162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009163 ATP binding site [chemical binding]; other site 431943009164 Mg2+ binding site [ion binding]; other site 431943009165 G-X-G motif; other site 431943009166 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 431943009167 anti sigma factor interaction site; other site 431943009168 regulatory phosphorylation site [posttranslational modification]; other site 431943009169 spermidine synthase; Provisional; Region: PRK00811 431943009170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943009171 S-adenosylmethionine binding site [chemical binding]; other site 431943009172 Methyltransferase domain; Region: Methyltransf_26; pfam13659 431943009173 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 431943009174 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 431943009175 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 431943009176 NodB motif; other site 431943009177 active site 431943009178 catalytic site [active] 431943009179 Cd binding site [ion binding]; other site 431943009180 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 431943009181 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 431943009182 Bacterial sugar transferase; Region: Bac_transf; pfam02397 431943009183 Acyltransferase family; Region: Acyl_transf_3; pfam01757 431943009184 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 431943009185 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 431943009186 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 431943009187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943009188 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 431943009189 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 431943009190 O-Antigen ligase; Region: Wzy_C; cl04850 431943009191 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 431943009192 active site 431943009193 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 431943009194 homodimer interface [polypeptide binding]; other site 431943009195 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 431943009196 putative trimer interface [polypeptide binding]; other site 431943009197 putative CoA binding site [chemical binding]; other site 431943009198 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 431943009199 putative trimer interface [polypeptide binding]; other site 431943009200 putative active site [active] 431943009201 putative substrate binding site [chemical binding]; other site 431943009202 putative CoA binding site [chemical binding]; other site 431943009203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 431943009204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 431943009205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 431943009206 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 431943009207 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 431943009208 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 431943009209 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 431943009210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 431943009211 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 431943009212 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 431943009213 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 431943009214 Acyltransferase family; Region: Acyl_transf_3; pfam01757 431943009215 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 431943009216 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 431943009217 Ligand binding site; other site 431943009218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943009219 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943009220 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943009221 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 431943009222 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 431943009223 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 431943009224 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 431943009225 NAD(P) binding site [chemical binding]; other site 431943009226 homodimer interface [polypeptide binding]; other site 431943009227 substrate binding site [chemical binding]; other site 431943009228 active site 431943009229 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 431943009230 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 431943009231 active site 431943009232 tetramer interface; other site 431943009233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 431943009234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943009235 binding surface 431943009236 TPR motif; other site 431943009237 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 431943009238 active site 431943009239 substrate binding site [chemical binding]; other site 431943009240 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 431943009241 metal binding site [ion binding]; metal-binding site 431943009242 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 431943009243 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 431943009244 homodimer interface [polypeptide binding]; other site 431943009245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943009246 catalytic residue [active] 431943009247 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 431943009248 Uncharacterized conserved protein [Function unknown]; Region: COG1683 431943009249 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 431943009250 MutS domain III; Region: MutS_III; pfam05192 431943009251 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 431943009252 Walker A/P-loop; other site 431943009253 ATP binding site [chemical binding]; other site 431943009254 Q-loop/lid; other site 431943009255 ABC transporter signature motif; other site 431943009256 Walker B; other site 431943009257 D-loop; other site 431943009258 H-loop/switch region; other site 431943009259 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 431943009260 Smr domain; Region: Smr; pfam01713 431943009261 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 431943009262 Peptidase family U32; Region: Peptidase_U32; pfam01136 431943009263 Collagenase; Region: DUF3656; pfam12392 431943009264 Peptidase family U32; Region: Peptidase_U32; cl03113 431943009265 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 431943009266 Cell division protein ZapA; Region: ZapA; pfam05164 431943009267 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 431943009268 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 431943009269 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 431943009270 putative tRNA-binding site [nucleotide binding]; other site 431943009271 B3/4 domain; Region: B3_4; pfam03483 431943009272 tRNA synthetase B5 domain; Region: B5; smart00874 431943009273 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 431943009274 dimer interface [polypeptide binding]; other site 431943009275 motif 1; other site 431943009276 motif 3; other site 431943009277 motif 2; other site 431943009278 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 431943009279 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 431943009280 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 431943009281 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 431943009282 dimer interface [polypeptide binding]; other site 431943009283 motif 1; other site 431943009284 active site 431943009285 motif 2; other site 431943009286 motif 3; other site 431943009287 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 431943009288 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 431943009289 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 431943009290 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 431943009291 23S rRNA binding site [nucleotide binding]; other site 431943009292 L21 binding site [polypeptide binding]; other site 431943009293 L13 binding site [polypeptide binding]; other site 431943009294 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 431943009295 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 431943009296 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 431943009297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 431943009298 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 431943009299 active site 431943009300 dimer interface [polypeptide binding]; other site 431943009301 motif 1; other site 431943009302 motif 2; other site 431943009303 motif 3; other site 431943009304 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 431943009305 anticodon binding site; other site 431943009306 YtxC-like family; Region: YtxC; pfam08812 431943009307 PAS domain; Region: PAS; smart00091 431943009308 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 431943009309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943009310 putative active site [active] 431943009311 heme pocket [chemical binding]; other site 431943009312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943009313 dimer interface [polypeptide binding]; other site 431943009314 phosphorylation site [posttranslational modification] 431943009315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009316 ATP binding site [chemical binding]; other site 431943009317 Mg2+ binding site [ion binding]; other site 431943009318 G-X-G motif; other site 431943009319 aminotransferase A; Validated; Region: PRK07683 431943009320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 431943009321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943009322 homodimer interface [polypeptide binding]; other site 431943009323 catalytic residue [active] 431943009324 dihydrodipicolinate reductase; Provisional; Region: PRK00048 431943009325 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 431943009326 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 431943009327 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 431943009328 dihydrodipicolinate synthase; Region: dapA; TIGR00674 431943009329 dimer interface [polypeptide binding]; other site 431943009330 active site 431943009331 catalytic residue [active] 431943009332 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 431943009333 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 431943009334 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943009335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943009336 S-adenosylmethionine binding site [chemical binding]; other site 431943009337 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 431943009338 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 431943009339 dimerization interface [polypeptide binding]; other site 431943009340 domain crossover interface; other site 431943009341 redox-dependent activation switch; other site 431943009342 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 431943009343 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 431943009344 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 431943009345 trimer interface [polypeptide binding]; other site 431943009346 active site 431943009347 substrate binding site [chemical binding]; other site 431943009348 CoA binding site [chemical binding]; other site 431943009349 single-stranded DNA-binding protein; Provisional; Region: PRK05813 431943009350 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 431943009351 dimer interface [polypeptide binding]; other site 431943009352 ssDNA binding site [nucleotide binding]; other site 431943009353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 431943009354 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943009355 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 431943009356 NodB motif; other site 431943009357 active site 431943009358 catalytic site [active] 431943009359 metal binding site [ion binding]; metal-binding site 431943009360 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 431943009361 Uncharacterized conserved protein [Function unknown]; Region: COG3391 431943009362 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 431943009363 TSCPD domain; Region: TSCPD; cl14834 431943009364 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 431943009365 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 431943009366 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 431943009367 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 431943009368 active site 431943009369 HIGH motif; other site 431943009370 nucleotide binding site [chemical binding]; other site 431943009371 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 431943009372 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 431943009373 active site 431943009374 KMSKS motif; other site 431943009375 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 431943009376 tRNA binding surface [nucleotide binding]; other site 431943009377 anticodon binding site; other site 431943009378 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 431943009379 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 431943009380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 431943009381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943009383 non-specific DNA binding site [nucleotide binding]; other site 431943009384 salt bridge; other site 431943009385 sequence-specific DNA binding site [nucleotide binding]; other site 431943009386 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943009387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009388 non-specific DNA binding site [nucleotide binding]; other site 431943009389 salt bridge; other site 431943009390 sequence-specific DNA binding site [nucleotide binding]; other site 431943009391 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 431943009392 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943009393 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 431943009394 putative catalytic residues [active] 431943009395 catalytic nucleophile [active] 431943009396 Recombinase; Region: Recombinase; pfam07508 431943009397 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943009398 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 431943009399 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 431943009400 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 431943009401 Phage capsid family; Region: Phage_capsid; pfam05065 431943009402 Uncharacterized conserved protein [Function unknown]; Region: COG4983 431943009403 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 431943009404 D5 N terminal like; Region: D5_N; smart00885 431943009405 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 431943009406 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 431943009407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009408 non-specific DNA binding site [nucleotide binding]; other site 431943009409 salt bridge; other site 431943009410 sequence-specific DNA binding site [nucleotide binding]; other site 431943009411 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 431943009412 DNA methylase; Region: N6_N4_Mtase; pfam01555 431943009413 DNA methylase; Region: N6_N4_Mtase; cl17433 431943009414 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 431943009415 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 431943009416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 431943009417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943009418 AAA domain; Region: AAA_21; pfam13304 431943009419 Walker A/P-loop; other site 431943009420 ATP binding site [chemical binding]; other site 431943009421 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 431943009422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943009423 Walker B; other site 431943009424 D-loop; other site 431943009425 H-loop/switch region; other site 431943009426 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 431943009427 putative active site [active] 431943009428 putative metal-binding site [ion binding]; other site 431943009429 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 431943009430 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 431943009431 active site 431943009432 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943009433 Holin family; Region: Phage_holin_4; pfam05105 431943009434 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 431943009435 Baseplate J-like protein; Region: Baseplate_J; pfam04865 431943009436 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 431943009437 Bacterial SH3 domain; Region: SH3_3; pfam08239 431943009438 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 431943009439 Phage XkdN-like protein; Region: XkdN; pfam08890 431943009440 ORF6N domain; Region: ORF6N; pfam10543 431943009441 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 431943009442 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 431943009443 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 431943009444 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 431943009445 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 431943009446 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 431943009447 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 431943009448 Terminase-like family; Region: Terminase_6; pfam03237 431943009449 Terminase small subunit; Region: Terminase_2; pfam03592 431943009450 YcfA-like protein; Region: YcfA; pfam07927 431943009451 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 431943009452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 431943009453 DNA binding residues [nucleotide binding] 431943009454 dimerization interface [polypeptide binding]; other site 431943009455 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 431943009456 Double zinc ribbon; Region: DZR; pfam12773 431943009457 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 431943009458 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 431943009459 cofactor binding site; other site 431943009460 DNA binding site [nucleotide binding] 431943009461 substrate interaction site [chemical binding]; other site 431943009462 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943009463 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 431943009464 replicative DNA helicase; Region: DnaB; TIGR00665 431943009465 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 431943009466 Walker A motif; other site 431943009467 ATP binding site [chemical binding]; other site 431943009468 Walker B motif; other site 431943009469 DNA binding loops [nucleotide binding] 431943009470 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 431943009471 exodeoxyribonuclease X; Provisional; Region: PRK07983 431943009472 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 431943009473 YopX protein; Region: YopX; pfam09643 431943009474 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 431943009475 ORF6N domain; Region: ORF6N; pfam10543 431943009476 ORF6C domain; Region: ORF6C; pfam10552 431943009477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943009478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009479 non-specific DNA binding site [nucleotide binding]; other site 431943009480 salt bridge; other site 431943009481 sequence-specific DNA binding site [nucleotide binding]; other site 431943009482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943009483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009484 non-specific DNA binding site [nucleotide binding]; other site 431943009485 salt bridge; other site 431943009486 sequence-specific DNA binding site [nucleotide binding]; other site 431943009487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009488 non-specific DNA binding site [nucleotide binding]; other site 431943009489 salt bridge; other site 431943009490 sequence-specific DNA binding site [nucleotide binding]; other site 431943009491 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943009492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009493 non-specific DNA binding site [nucleotide binding]; other site 431943009494 salt bridge; other site 431943009495 sequence-specific DNA binding site [nucleotide binding]; other site 431943009496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009497 non-specific DNA binding site [nucleotide binding]; other site 431943009498 salt bridge; other site 431943009499 sequence-specific DNA binding site [nucleotide binding]; other site 431943009500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009501 ATP binding site [chemical binding]; other site 431943009502 Mg2+ binding site [ion binding]; other site 431943009503 G-X-G motif; other site 431943009504 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943009505 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 431943009506 catalytic residues [active] 431943009507 catalytic nucleophile [active] 431943009508 Presynaptic Site I dimer interface [polypeptide binding]; other site 431943009509 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 431943009510 Synaptic Flat tetramer interface [polypeptide binding]; other site 431943009511 Synaptic Site I dimer interface [polypeptide binding]; other site 431943009512 DNA binding site [nucleotide binding] 431943009513 Recombinase; Region: Recombinase; pfam07508 431943009514 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943009515 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 431943009516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943009517 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943009518 Rubrerythrin [Energy production and conversion]; Region: COG1592 431943009519 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 431943009520 iron binding site [ion binding]; other site 431943009521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 431943009522 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 431943009523 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 431943009524 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 431943009525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 431943009526 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 431943009527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 431943009528 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 431943009529 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 431943009530 Walker A/P-loop; other site 431943009531 ATP binding site [chemical binding]; other site 431943009532 Q-loop/lid; other site 431943009533 ABC transporter signature motif; other site 431943009534 Walker B; other site 431943009535 D-loop; other site 431943009536 H-loop/switch region; other site 431943009537 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 431943009538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 431943009539 dimer interface [polypeptide binding]; other site 431943009540 conserved gate region; other site 431943009541 putative PBP binding loops; other site 431943009542 ABC-ATPase subunit interface; other site 431943009543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 431943009544 binding surface 431943009545 TPR repeat; Region: TPR_11; pfam13414 431943009546 TPR motif; other site 431943009547 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 431943009548 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 431943009549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943009550 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943009551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943009552 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943009553 recombination regulator RecX; Provisional; Region: recX; PRK14134 431943009554 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 431943009555 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 431943009556 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 431943009557 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 431943009558 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 431943009559 ATP binding site [chemical binding]; other site 431943009560 Mg++ binding site [ion binding]; other site 431943009561 motif III; other site 431943009562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943009563 nucleotide binding region [chemical binding]; other site 431943009564 ATP-binding site [chemical binding]; other site 431943009565 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 431943009566 RNA binding site [nucleotide binding]; other site 431943009567 Uncharacterized conserved protein [Function unknown]; Region: COG1543 431943009568 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 431943009569 active site 431943009570 substrate binding site [chemical binding]; other site 431943009571 catalytic site [active] 431943009572 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 431943009573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 431943009574 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 431943009575 putative deacylase active site [active] 431943009576 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 431943009577 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 431943009578 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 431943009579 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 431943009580 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 431943009581 catalytic residue [active] 431943009582 putative FPP diphosphate binding site; other site 431943009583 putative FPP binding hydrophobic cleft; other site 431943009584 dimer interface [polypeptide binding]; other site 431943009585 putative IPP diphosphate binding site; other site 431943009586 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 431943009587 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 431943009588 dimer interface [polypeptide binding]; other site 431943009589 PYR/PP interface [polypeptide binding]; other site 431943009590 TPP binding site [chemical binding]; other site 431943009591 substrate binding site [chemical binding]; other site 431943009592 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 431943009593 Domain of unknown function; Region: EKR; smart00890 431943009594 4Fe-4S binding domain; Region: Fer4_6; pfam12837 431943009595 4Fe-4S binding domain; Region: Fer4; pfam00037 431943009596 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 431943009597 TPP-binding site [chemical binding]; other site 431943009598 dimer interface [polypeptide binding]; other site 431943009599 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 431943009600 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 431943009601 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 431943009602 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 431943009603 ApbE family; Region: ApbE; pfam02424 431943009604 cobalamin synthase; Reviewed; Region: cobS; PRK00235 431943009605 ferric uptake regulator; Provisional; Region: fur; PRK09462 431943009606 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943009607 metal binding site 2 [ion binding]; metal-binding site 431943009608 putative DNA binding helix; other site 431943009609 metal binding site 1 [ion binding]; metal-binding site 431943009610 dimer interface [polypeptide binding]; other site 431943009611 structural Zn2+ binding site [ion binding]; other site 431943009612 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 431943009613 Family description; Region: VCBS; pfam13517 431943009614 Predicted transcriptional regulator [Transcription]; Region: COG2378 431943009615 HTH domain; Region: HTH_11; pfam08279 431943009616 WYL domain; Region: WYL; pfam13280 431943009617 CAAX protease self-immunity; Region: Abi; cl00558 431943009618 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 431943009619 G1 box; other site 431943009620 GTP/Mg2+ binding site [chemical binding]; other site 431943009621 Switch I region; other site 431943009622 G2 box; other site 431943009623 G3 box; other site 431943009624 Switch II region; other site 431943009625 G4 box; other site 431943009626 G5 box; other site 431943009627 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 431943009628 Found in ATP-dependent protease La (LON); Region: LON; smart00464 431943009629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943009630 Walker A motif; other site 431943009631 ATP binding site [chemical binding]; other site 431943009632 Walker B motif; other site 431943009633 arginine finger; other site 431943009634 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 431943009635 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 431943009636 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 431943009637 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 431943009638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943009639 Walker A motif; other site 431943009640 ATP binding site [chemical binding]; other site 431943009641 Walker B motif; other site 431943009642 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 431943009643 Clp protease; Region: CLP_protease; pfam00574 431943009644 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 431943009645 oligomer interface [polypeptide binding]; other site 431943009646 active site residues [active] 431943009647 trigger factor; Provisional; Region: tig; PRK01490 431943009648 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 431943009649 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 431943009650 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 431943009651 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 431943009652 Metal-binding active site; metal-binding site 431943009653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943009654 active site 431943009655 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 431943009656 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 431943009657 heterodimer interface [polypeptide binding]; other site 431943009658 active site 431943009659 FMN binding site [chemical binding]; other site 431943009660 homodimer interface [polypeptide binding]; other site 431943009661 substrate binding site [chemical binding]; other site 431943009662 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 431943009663 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 431943009664 FAD binding pocket [chemical binding]; other site 431943009665 FAD binding motif [chemical binding]; other site 431943009666 phosphate binding motif [ion binding]; other site 431943009667 beta-alpha-beta structure motif; other site 431943009668 NAD binding pocket [chemical binding]; other site 431943009669 Iron coordination center [ion binding]; other site 431943009670 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 431943009671 active site 431943009672 dimer interface [polypeptide binding]; other site 431943009673 dihydroorotase; Validated; Region: pyrC; PRK09357 431943009674 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 431943009675 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 431943009676 active site 431943009677 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 431943009678 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 431943009679 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 431943009680 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 431943009681 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 431943009682 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 431943009683 manganese transport transcriptional regulator; Provisional; Region: PRK03902 431943009684 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 431943009685 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 431943009686 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 431943009687 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 431943009688 active site 431943009689 tetramer interface; other site 431943009690 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 431943009691 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943009692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943009693 Accessory gene regulator B; Region: AgrB; pfam04647 431943009694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009695 ATP binding site [chemical binding]; other site 431943009696 Mg2+ binding site [ion binding]; other site 431943009697 G-X-G motif; other site 431943009698 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 431943009699 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 431943009700 Nitrogen regulatory protein P-II; Region: P-II; smart00938 431943009701 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 431943009702 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 431943009703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943009704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943009705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943009706 dimerization interface [polypeptide binding]; other site 431943009707 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 431943009708 SmpB-tmRNA interface; other site 431943009709 ribonuclease R; Region: RNase_R; TIGR02063 431943009710 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 431943009711 RNA binding site [nucleotide binding]; other site 431943009712 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 431943009713 RNB domain; Region: RNB; pfam00773 431943009714 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 431943009715 RNA binding site [nucleotide binding]; other site 431943009716 Preprotein translocase SecG subunit; Region: SecG; pfam03840 431943009717 enolase; Provisional; Region: eno; PRK00077 431943009718 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 431943009719 dimer interface [polypeptide binding]; other site 431943009720 metal binding site [ion binding]; metal-binding site 431943009721 substrate binding pocket [chemical binding]; other site 431943009722 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 431943009723 phosphoglyceromutase; Provisional; Region: PRK05434 431943009724 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 431943009725 triosephosphate isomerase; Provisional; Region: PRK14565 431943009726 substrate binding site [chemical binding]; other site 431943009727 dimer interface [polypeptide binding]; other site 431943009728 catalytic triad [active] 431943009729 Phosphoglycerate kinase; Region: PGK; pfam00162 431943009730 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 431943009731 substrate binding site [chemical binding]; other site 431943009732 hinge regions; other site 431943009733 ADP binding site [chemical binding]; other site 431943009734 catalytic site [active] 431943009735 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 431943009736 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 431943009737 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 431943009738 EDD domain protein, DegV family; Region: DegV; TIGR00762 431943009739 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 431943009740 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 431943009741 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943009742 Radical SAM superfamily; Region: Radical_SAM; pfam04055 431943009743 FeS/SAM binding site; other site 431943009744 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 431943009745 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 431943009746 active site 431943009747 metal binding site [ion binding]; metal-binding site 431943009748 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 431943009749 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 431943009750 Hexamer interface [polypeptide binding]; other site 431943009751 Hexagonal pore residue; other site 431943009752 Uncharacterized conserved protein [Function unknown]; Region: COG5663 431943009753 EamA-like transporter family; Region: EamA; pfam00892 431943009754 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 431943009755 EamA-like transporter family; Region: EamA; pfam00892 431943009756 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943009757 FtsX-like permease family; Region: FtsX; pfam02687 431943009758 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943009759 FtsX-like permease family; Region: FtsX; pfam02687 431943009760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943009761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943009762 Walker A/P-loop; other site 431943009763 ATP binding site [chemical binding]; other site 431943009764 Q-loop/lid; other site 431943009765 ABC transporter signature motif; other site 431943009766 Walker B; other site 431943009767 D-loop; other site 431943009768 H-loop/switch region; other site 431943009769 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 431943009770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943009771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943009772 dimer interface [polypeptide binding]; other site 431943009773 phosphorylation site [posttranslational modification] 431943009774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943009775 ATP binding site [chemical binding]; other site 431943009776 Mg2+ binding site [ion binding]; other site 431943009777 G-X-G motif; other site 431943009778 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943009779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943009780 active site 431943009781 phosphorylation site [posttranslational modification] 431943009782 intermolecular recognition site; other site 431943009783 dimerization interface [polypeptide binding]; other site 431943009784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943009785 DNA binding site [nucleotide binding] 431943009786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943009787 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943009788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943009789 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943009790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943009791 salt bridge; other site 431943009792 non-specific DNA binding site [nucleotide binding]; other site 431943009793 sequence-specific DNA binding site [nucleotide binding]; other site 431943009794 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 431943009795 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 431943009796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943009797 MarR family; Region: MarR; pfam01047 431943009798 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 431943009799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943009800 putative substrate translocation pore; other site 431943009801 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 431943009802 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 431943009803 active site 431943009804 Amino acid permease; Region: AA_permease_2; pfam13520 431943009805 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 431943009806 Integrase core domain; Region: rve; pfam00665 431943009807 Integrase core domain; Region: rve_3; pfam13683 431943009808 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 431943009809 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 431943009810 VanW like protein; Region: VanW; pfam04294 431943009811 competence damage-inducible protein A; Provisional; Region: PRK00549 431943009812 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 431943009813 putative MPT binding site; other site 431943009814 Competence-damaged protein; Region: CinA; pfam02464 431943009815 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 431943009816 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 431943009817 minor groove reading motif; other site 431943009818 helix-hairpin-helix signature motif; other site 431943009819 substrate binding pocket [chemical binding]; other site 431943009820 active site 431943009821 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 431943009822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 431943009823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 431943009824 putative acyl-acceptor binding pocket; other site 431943009825 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 431943009826 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 431943009827 trimer interface [polypeptide binding]; other site 431943009828 active site 431943009829 substrate binding site [chemical binding]; other site 431943009830 CoA binding site [chemical binding]; other site 431943009831 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 431943009832 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 431943009833 dimer interface [polypeptide binding]; other site 431943009834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943009835 catalytic residue [active] 431943009836 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 431943009837 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943009838 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943009839 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 431943009840 G1 box; other site 431943009841 GTP/Mg2+ binding site [chemical binding]; other site 431943009842 G2 box; other site 431943009843 Switch I region; other site 431943009844 G3 box; other site 431943009845 Switch II region; other site 431943009846 G4 box; other site 431943009847 G5 box; other site 431943009848 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 431943009849 putative hexamer interface [polypeptide binding]; other site 431943009850 putative hexagonal pore; other site 431943009851 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 431943009852 Rubredoxin; Region: Rubredoxin; pfam00301 431943009853 iron binding site [ion binding]; other site 431943009854 Rubrerythrin [Energy production and conversion]; Region: COG1592 431943009855 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 431943009856 diiron binding motif [ion binding]; other site 431943009857 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 431943009858 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 431943009859 GTPase; Provisional; Region: PRK13768 431943009860 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 431943009861 G1 box; other site 431943009862 GTP/Mg2+ binding site [chemical binding]; other site 431943009863 G2 box; other site 431943009864 Switch I region; other site 431943009865 G3 box; other site 431943009866 Switch II region; other site 431943009867 G4 box; other site 431943009868 G5 box; other site 431943009869 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 431943009870 Predicted membrane protein [Function unknown]; Region: COG2364 431943009871 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 431943009872 Predicted membrane protein [Function unknown]; Region: COG2119 431943009873 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 431943009874 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 431943009875 EamA-like transporter family; Region: EamA; pfam00892 431943009876 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 431943009877 EamA-like transporter family; Region: EamA; pfam00892 431943009878 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943009879 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 431943009880 dimer interface [polypeptide binding]; other site 431943009881 active site 431943009882 metal binding site [ion binding]; metal-binding site 431943009883 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 431943009884 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 431943009885 Walker A/P-loop; other site 431943009886 ATP binding site [chemical binding]; other site 431943009887 Q-loop/lid; other site 431943009888 ABC transporter signature motif; other site 431943009889 Walker B; other site 431943009890 D-loop; other site 431943009891 H-loop/switch region; other site 431943009892 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 431943009893 cobalt transport protein CbiN; Provisional; Region: PRK02898 431943009894 cobalt transport protein CbiM; Validated; Region: PRK08319 431943009895 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 431943009896 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 431943009897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 431943009898 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 431943009899 Sensory domain found in PocR; Region: PocR; pfam10114 431943009900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943009901 dimer interface [polypeptide binding]; other site 431943009902 putative CheW interface [polypeptide binding]; other site 431943009903 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 431943009904 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 431943009905 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 431943009906 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943009907 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 431943009908 metal binding site 2 [ion binding]; metal-binding site 431943009909 putative DNA binding helix; other site 431943009910 metal binding site 1 [ion binding]; metal-binding site 431943009911 dimer interface [polypeptide binding]; other site 431943009912 structural Zn2+ binding site [ion binding]; other site 431943009913 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 431943009914 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 431943009915 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943009916 dimer interface [polypeptide binding]; other site 431943009917 putative CheW interface [polypeptide binding]; other site 431943009918 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 431943009919 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 431943009920 active site 431943009921 metal binding site [ion binding]; metal-binding site 431943009922 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 431943009923 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 431943009924 active site 431943009925 FMN binding site [chemical binding]; other site 431943009926 substrate binding site [chemical binding]; other site 431943009927 putative catalytic residue [active] 431943009928 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 431943009929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943009930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943009931 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 431943009932 GAF domain; Region: GAF; pfam01590 431943009933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 431943009934 putative active site [active] 431943009935 heme pocket [chemical binding]; other site 431943009936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943009937 Walker A motif; other site 431943009938 ATP binding site [chemical binding]; other site 431943009939 Walker B motif; other site 431943009940 arginine finger; other site 431943009941 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 431943009942 DNA polymerase IV; Validated; Region: PRK01810 431943009943 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 431943009944 active site 431943009945 DNA binding site [nucleotide binding] 431943009946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943009947 dimerization interface [polypeptide binding]; other site 431943009948 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 431943009949 dimer interface [polypeptide binding]; other site 431943009950 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 431943009951 putative CheW interface [polypeptide binding]; other site 431943009952 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 431943009953 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 431943009954 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943009955 putative transposase OrfB; Reviewed; Region: PHA02517 431943009956 HTH-like domain; Region: HTH_21; pfam13276 431943009957 Integrase core domain; Region: rve; pfam00665 431943009958 Integrase core domain; Region: rve_2; pfam13333 431943009959 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943009960 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 431943009961 active site 431943009962 metal binding site [ion binding]; metal-binding site 431943009963 homotetramer interface [polypeptide binding]; other site 431943009964 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 431943009965 active site 431943009966 dimerization interface [polypeptide binding]; other site 431943009967 ribonuclease PH; Reviewed; Region: rph; PRK00173 431943009968 Ribonuclease PH; Region: RNase_PH_bact; cd11362 431943009969 hexamer interface [polypeptide binding]; other site 431943009970 active site 431943009971 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 431943009972 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 431943009973 dimerization interface [polypeptide binding]; other site 431943009974 putative ATP binding site [chemical binding]; other site 431943009975 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 431943009976 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 431943009977 peptide binding site [polypeptide binding]; other site 431943009978 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 431943009979 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 431943009980 GatB domain; Region: GatB_Yqey; smart00845 431943009981 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 431943009982 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 431943009983 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 431943009984 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 431943009985 nucleophile elbow; other site 431943009986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943009987 Radical SAM superfamily; Region: Radical_SAM; pfam04055 431943009988 FeS/SAM binding site; other site 431943009989 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 431943009990 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 431943009991 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 431943009992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 431943009993 Predicted membrane protein [Function unknown]; Region: COG4905 431943009994 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 431943009995 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 431943009996 ABC1 family; Region: ABC1; pfam03109 431943009997 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 431943009998 active site 431943009999 ATP binding site [chemical binding]; other site 431943010000 Uncharacterized conserved protein [Function unknown]; Region: COG3937 431943010001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943010002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943010003 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 431943010004 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 431943010005 nucleotide binding pocket [chemical binding]; other site 431943010006 K-X-D-G motif; other site 431943010007 catalytic site [active] 431943010008 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 431943010009 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 431943010010 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 431943010011 Dimer interface [polypeptide binding]; other site 431943010012 BRCT sequence motif; other site 431943010013 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 431943010014 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 431943010015 Part of AAA domain; Region: AAA_19; pfam13245 431943010016 Family description; Region: UvrD_C_2; pfam13538 431943010017 Trp repressor protein; Region: Trp_repressor; cl17266 431943010018 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 431943010019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 431943010020 RNA binding surface [nucleotide binding]; other site 431943010021 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 431943010022 active site 431943010023 uracil binding [chemical binding]; other site 431943010024 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 431943010025 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 431943010026 N-acetyl-D-glucosamine binding site [chemical binding]; other site 431943010027 catalytic residue [active] 431943010028 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 431943010029 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 431943010030 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 431943010031 pullulanase, type I; Region: pulA_typeI; TIGR02104 431943010032 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 431943010033 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 431943010034 Ca binding site [ion binding]; other site 431943010035 active site 431943010036 catalytic site [active] 431943010037 hypothetical protein; Validated; Region: PRK00124 431943010038 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 431943010039 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 431943010040 active site 431943010041 dimer interface [polypeptide binding]; other site 431943010042 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 431943010043 dimer interface [polypeptide binding]; other site 431943010044 active site 431943010045 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943010046 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 431943010047 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 431943010048 ligand binding site; other site 431943010049 oligomer interface; other site 431943010050 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 431943010051 dimer interface [polypeptide binding]; other site 431943010052 N-terminal domain interface [polypeptide binding]; other site 431943010053 sulfate 1 binding site; other site 431943010054 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 431943010055 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 431943010056 ligand binding site; other site 431943010057 oligomer interface; other site 431943010058 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 431943010059 dimer interface [polypeptide binding]; other site 431943010060 N-terminal domain interface [polypeptide binding]; other site 431943010061 sulfate 1 binding site; other site 431943010062 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 431943010063 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 431943010064 active site 431943010065 homodimer interface [polypeptide binding]; other site 431943010066 catalytic site [active] 431943010067 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 431943010068 homodimer interface [polypeptide binding]; other site 431943010069 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 431943010070 active site pocket [active] 431943010071 glycogen synthase; Provisional; Region: glgA; PRK00654 431943010072 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 431943010073 ADP-binding pocket [chemical binding]; other site 431943010074 homodimer interface [polypeptide binding]; other site 431943010075 glycogen branching enzyme; Provisional; Region: PRK12313 431943010076 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 431943010077 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 431943010078 active site 431943010079 catalytic site [active] 431943010080 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 431943010081 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 431943010082 Penicillinase repressor; Region: Pencillinase_R; cl17580 431943010083 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 431943010084 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 431943010085 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 431943010086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 431943010087 MarR family; Region: MarR; pfam01047 431943010088 MarR family; Region: MarR_2; cl17246 431943010089 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 431943010090 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 431943010091 active site 431943010092 zinc binding site [ion binding]; other site 431943010093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 431943010094 putative substrate translocation pore; other site 431943010095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943010096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943010097 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 431943010098 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 431943010099 E3 interaction surface; other site 431943010100 lipoyl attachment site [posttranslational modification]; other site 431943010101 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943010102 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 431943010103 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 431943010104 Walker A/P-loop; other site 431943010105 ATP binding site [chemical binding]; other site 431943010106 Q-loop/lid; other site 431943010107 ABC transporter signature motif; other site 431943010108 Walker B; other site 431943010109 D-loop; other site 431943010110 H-loop/switch region; other site 431943010111 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 431943010112 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 431943010113 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 431943010114 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 431943010115 active site 431943010116 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 431943010117 FAD binding domain; Region: FAD_binding_4; pfam01565 431943010118 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 431943010119 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 431943010120 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 431943010121 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 431943010122 Ligand binding site [chemical binding]; other site 431943010123 Electron transfer flavoprotein domain; Region: ETF; pfam01012 431943010124 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 431943010125 Domain of unknown function DUF21; Region: DUF21; pfam01595 431943010126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 431943010127 Transporter associated domain; Region: CorC_HlyC; smart01091 431943010128 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 431943010129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010130 Walker A/P-loop; other site 431943010131 ATP binding site [chemical binding]; other site 431943010132 Q-loop/lid; other site 431943010133 ABC transporter signature motif; other site 431943010134 Walker B; other site 431943010135 D-loop; other site 431943010136 H-loop/switch region; other site 431943010137 Response regulator receiver domain; Region: Response_reg; pfam00072 431943010138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943010139 active site 431943010140 phosphorylation site [posttranslational modification] 431943010141 intermolecular recognition site; other site 431943010142 dimerization interface [polypeptide binding]; other site 431943010143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943010144 DNA binding site [nucleotide binding] 431943010145 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 431943010146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 431943010147 ligand binding site [chemical binding]; other site 431943010148 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 431943010149 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 431943010150 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 431943010151 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 431943010152 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 431943010153 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 431943010154 active site 431943010155 HIGH motif; other site 431943010156 dimer interface [polypeptide binding]; other site 431943010157 KMSKS motif; other site 431943010158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 431943010159 RNA binding surface [nucleotide binding]; other site 431943010160 Predicted permeases [General function prediction only]; Region: COG0730 431943010161 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943010162 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943010163 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 431943010164 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 431943010165 ABC-2 type transporter; Region: ABC2_membrane; cl17235 431943010166 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 431943010167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010168 Walker A/P-loop; other site 431943010169 ATP binding site [chemical binding]; other site 431943010170 Q-loop/lid; other site 431943010171 ABC transporter signature motif; other site 431943010172 Walker B; other site 431943010173 D-loop; other site 431943010174 H-loop/switch region; other site 431943010175 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 431943010176 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 431943010177 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943010178 Transcriptional regulator PadR-like family; Region: PadR; cl17335 431943010179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010180 Walker A/P-loop; other site 431943010181 ATP binding site [chemical binding]; other site 431943010182 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 431943010183 Predicted transcriptional regulators [Transcription]; Region: COG1695 431943010184 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 431943010185 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943010186 FtsX-like permease family; Region: FtsX; pfam02687 431943010187 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943010188 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943010189 Walker A/P-loop; other site 431943010190 ATP binding site [chemical binding]; other site 431943010191 Q-loop/lid; other site 431943010192 ABC transporter signature motif; other site 431943010193 Walker B; other site 431943010194 D-loop; other site 431943010195 H-loop/switch region; other site 431943010196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943010197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943010198 ATP binding site [chemical binding]; other site 431943010199 Mg2+ binding site [ion binding]; other site 431943010200 G-X-G motif; other site 431943010201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943010202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943010203 active site 431943010204 phosphorylation site [posttranslational modification] 431943010205 intermolecular recognition site; other site 431943010206 dimerization interface [polypeptide binding]; other site 431943010207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943010208 DNA binding site [nucleotide binding] 431943010209 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 431943010210 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 431943010211 Integrase core domain; Region: rve; pfam00665 431943010212 FtsX-like permease family; Region: FtsX; pfam02687 431943010213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943010214 FtsX-like permease family; Region: FtsX; pfam02687 431943010215 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943010216 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943010217 Walker A/P-loop; other site 431943010218 ATP binding site [chemical binding]; other site 431943010219 Q-loop/lid; other site 431943010220 ABC transporter signature motif; other site 431943010221 Walker B; other site 431943010222 D-loop; other site 431943010223 H-loop/switch region; other site 431943010224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943010225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943010226 dimer interface [polypeptide binding]; other site 431943010227 phosphorylation site [posttranslational modification] 431943010228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943010229 ATP binding site [chemical binding]; other site 431943010230 Mg2+ binding site [ion binding]; other site 431943010231 G-X-G motif; other site 431943010232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943010233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943010234 active site 431943010235 phosphorylation site [posttranslational modification] 431943010236 intermolecular recognition site; other site 431943010237 dimerization interface [polypeptide binding]; other site 431943010238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943010239 DNA binding site [nucleotide binding] 431943010240 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943010241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 431943010242 TRAM domain; Region: TRAM; cl01282 431943010243 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 431943010244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943010245 S-adenosylmethionine binding site [chemical binding]; other site 431943010246 pyruvate kinase; Provisional; Region: PRK06354 431943010247 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 431943010248 domain interfaces; other site 431943010249 active site 431943010250 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 431943010251 6-phosphofructokinase; Provisional; Region: PRK03202 431943010252 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 431943010253 active site 431943010254 ADP/pyrophosphate binding site [chemical binding]; other site 431943010255 dimerization interface [polypeptide binding]; other site 431943010256 allosteric effector site; other site 431943010257 fructose-1,6-bisphosphate binding site; other site 431943010258 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 431943010259 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 431943010260 active site 431943010261 PHP Thumb interface [polypeptide binding]; other site 431943010262 metal binding site [ion binding]; metal-binding site 431943010263 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 431943010264 generic binding surface II; other site 431943010265 generic binding surface I; other site 431943010266 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 431943010267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943010268 DNA-binding site [nucleotide binding]; DNA binding site 431943010269 DRTGG domain; Region: DRTGG; pfam07085 431943010270 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 431943010271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 431943010272 active site 2 [active] 431943010273 active site 1 [active] 431943010274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 431943010275 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 431943010276 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 431943010277 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 431943010278 phosphate binding site [ion binding]; other site 431943010279 putative substrate binding pocket [chemical binding]; other site 431943010280 dimer interface [polypeptide binding]; other site 431943010281 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 431943010282 AAA domain; Region: AAA_18; pfam13238 431943010283 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 431943010284 FAD binding domain; Region: FAD_binding_4; pfam01565 431943010285 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 431943010286 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 431943010287 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 431943010288 GIY-YIG motif/motif A; other site 431943010289 active site 431943010290 catalytic site [active] 431943010291 putative DNA binding site [nucleotide binding]; other site 431943010292 metal binding site [ion binding]; metal-binding site 431943010293 UvrB/uvrC motif; Region: UVR; pfam02151 431943010294 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 431943010295 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 431943010296 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 431943010297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 431943010298 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 431943010299 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 431943010300 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 431943010301 phosphopeptide binding site; other site 431943010302 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 431943010303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 431943010304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 431943010305 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 431943010306 excinuclease ABC subunit B; Provisional; Region: PRK05298 431943010307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 431943010308 ATP binding site [chemical binding]; other site 431943010309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 431943010310 putative Mg++ binding site [ion binding]; other site 431943010311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 431943010312 nucleotide binding region [chemical binding]; other site 431943010313 ATP-binding site [chemical binding]; other site 431943010314 Ultra-violet resistance protein B; Region: UvrB; pfam12344 431943010315 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 431943010316 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 431943010317 C-terminal peptidase (prc); Region: prc; TIGR00225 431943010318 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 431943010319 protein binding site [polypeptide binding]; other site 431943010320 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 431943010321 Catalytic dyad [active] 431943010322 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 431943010323 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 431943010324 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 431943010325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010326 Walker A/P-loop; other site 431943010327 ATP binding site [chemical binding]; other site 431943010328 Q-loop/lid; other site 431943010329 ABC transporter signature motif; other site 431943010330 Walker B; other site 431943010331 D-loop; other site 431943010332 H-loop/switch region; other site 431943010333 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 431943010334 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 431943010335 PYR/PP interface [polypeptide binding]; other site 431943010336 dimer interface [polypeptide binding]; other site 431943010337 TPP binding site [chemical binding]; other site 431943010338 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 431943010339 transketolase; Reviewed; Region: PRK05899 431943010340 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 431943010341 TPP-binding site [chemical binding]; other site 431943010342 dimer interface [polypeptide binding]; other site 431943010343 PemK-like protein; Region: PemK; pfam02452 431943010344 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 431943010345 alanine racemase; Reviewed; Region: alr; PRK00053 431943010346 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 431943010347 active site 431943010348 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 431943010349 dimer interface [polypeptide binding]; other site 431943010350 substrate binding site [chemical binding]; other site 431943010351 catalytic residues [active] 431943010352 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 431943010353 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 431943010354 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 431943010355 putative substrate binding site [chemical binding]; other site 431943010356 putative ATP binding site [chemical binding]; other site 431943010357 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 431943010358 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 431943010359 HPr interaction site; other site 431943010360 glycerol kinase (GK) interaction site [polypeptide binding]; other site 431943010361 active site 431943010362 phosphorylation site [posttranslational modification] 431943010363 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 431943010364 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 431943010365 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 431943010366 MgtE intracellular N domain; Region: MgtE_N; smart00924 431943010367 FOG: CBS domain [General function prediction only]; Region: COG0517 431943010368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 431943010369 putative lipid kinase; Reviewed; Region: PRK13059 431943010370 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 431943010371 FOG: CBS domain [General function prediction only]; Region: COG0517 431943010372 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 431943010373 FOG: CBS domain [General function prediction only]; Region: COG0517 431943010374 Uncharacterized conserved protein [Function unknown]; Region: COG0398 431943010375 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 431943010376 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 431943010377 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 431943010378 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 431943010379 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 431943010380 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 431943010381 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 431943010382 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 431943010383 active site 431943010384 Predicted membrane protein [Function unknown]; Region: COG2323 431943010385 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 431943010386 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 431943010387 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 431943010388 intersubunit interface [polypeptide binding]; other site 431943010389 active site 431943010390 zinc binding site [ion binding]; other site 431943010391 Na+ binding site [ion binding]; other site 431943010392 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 431943010393 putative active site [active] 431943010394 putative triphosphate binding site [ion binding]; other site 431943010395 dimer interface [polypeptide binding]; other site 431943010396 putative metal binding residues [ion binding]; other site 431943010397 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 431943010398 HSP70 interaction site [polypeptide binding]; other site 431943010399 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 431943010400 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 431943010401 HIGH motif; other site 431943010402 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 431943010403 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 431943010404 active site 431943010405 KMSKS motif; other site 431943010406 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 431943010407 tRNA binding surface [nucleotide binding]; other site 431943010408 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 431943010409 synthetase active site [active] 431943010410 NTP binding site [chemical binding]; other site 431943010411 metal binding site [ion binding]; metal-binding site 431943010412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 431943010413 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 431943010414 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 431943010415 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 431943010416 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 431943010417 Predicted membrane protein [Function unknown]; Region: COG3601 431943010418 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 431943010419 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 431943010420 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 431943010421 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 431943010422 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 431943010423 RNA binding site [nucleotide binding]; other site 431943010424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 431943010425 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 431943010426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 431943010427 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 431943010428 Walker A/P-loop; other site 431943010429 ATP binding site [chemical binding]; other site 431943010430 Q-loop/lid; other site 431943010431 ABC transporter signature motif; other site 431943010432 Walker B; other site 431943010433 D-loop; other site 431943010434 H-loop/switch region; other site 431943010435 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 431943010436 HlyD family secretion protein; Region: HlyD_3; pfam13437 431943010437 Yip1 domain; Region: Yip1; cl17815 431943010438 peptide chain release factor 2; Provisional; Region: PRK05589 431943010439 This domain is found in peptide chain release factors; Region: PCRF; smart00937 431943010440 RF-1 domain; Region: RF-1; pfam00472 431943010441 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 431943010442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 431943010443 ATP binding site [chemical binding]; other site 431943010444 putative Mg++ binding site [ion binding]; other site 431943010445 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 431943010446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 431943010447 nucleotide binding region [chemical binding]; other site 431943010448 ATP-binding site [chemical binding]; other site 431943010449 SEC-C motif; Region: SEC-C; pfam02810 431943010450 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 431943010451 30S subunit binding site; other site 431943010452 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 431943010453 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 431943010454 homodimer interface [polypeptide binding]; other site 431943010455 substrate-cofactor binding pocket; other site 431943010456 catalytic residue [active] 431943010457 Phage integrase family; Region: Phage_integrase; pfam00589 431943010458 active site 431943010459 DNA binding site [nucleotide binding] 431943010460 Int/Topo IB signature motif; other site 431943010461 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 431943010462 Acyltransferase family; Region: Acyl_transf_3; pfam01757 431943010463 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 431943010464 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 431943010465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 431943010466 UDP-galactopyranose mutase; Region: GLF; pfam03275 431943010467 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 431943010468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 431943010469 active site 431943010470 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 431943010471 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 431943010472 active site 431943010473 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 431943010474 GIY-YIG motif/motif A; other site 431943010475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943010476 non-specific DNA binding site [nucleotide binding]; other site 431943010477 salt bridge; other site 431943010478 sequence-specific DNA binding site [nucleotide binding]; other site 431943010479 4Fe-4S binding domain; Region: Fer4_5; pfam12801 431943010480 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943010481 Predicted permeases [General function prediction only]; Region: COG0701 431943010482 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 431943010483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943010484 dimerization interface [polypeptide binding]; other site 431943010485 putative DNA binding site [nucleotide binding]; other site 431943010486 putative Zn2+ binding site [ion binding]; other site 431943010487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943010488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943010489 active site 431943010490 phosphorylation site [posttranslational modification] 431943010491 intermolecular recognition site; other site 431943010492 dimerization interface [polypeptide binding]; other site 431943010493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943010494 DNA binding site [nucleotide binding] 431943010495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 431943010496 dimerization interface [polypeptide binding]; other site 431943010497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943010498 dimer interface [polypeptide binding]; other site 431943010499 phosphorylation site [posttranslational modification] 431943010500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943010501 ATP binding site [chemical binding]; other site 431943010502 Mg2+ binding site [ion binding]; other site 431943010503 G-X-G motif; other site 431943010504 Short C-terminal domain; Region: SHOCT; pfam09851 431943010505 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 431943010506 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 431943010507 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 431943010508 dimerization interface [polypeptide binding]; other site 431943010509 active site 431943010510 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 431943010511 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 431943010512 trimerization site [polypeptide binding]; other site 431943010513 active site 431943010514 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943010515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943010516 DNA binding residues [nucleotide binding] 431943010517 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 431943010518 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 431943010519 metal binding site 2 [ion binding]; metal-binding site 431943010520 putative DNA binding helix; other site 431943010521 metal binding site 1 [ion binding]; metal-binding site 431943010522 structural Zn2+ binding site [ion binding]; other site 431943010523 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 431943010524 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 431943010525 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 431943010526 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 431943010527 P loop nucleotide binding; other site 431943010528 switch II; other site 431943010529 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 431943010530 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 431943010531 switch II; other site 431943010532 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 431943010533 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 431943010534 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 431943010535 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 431943010536 EamA-like transporter family; Region: EamA; cl17759 431943010537 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 431943010538 EamA-like transporter family; Region: EamA; pfam00892 431943010539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 431943010540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 431943010541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 431943010542 dimerization interface [polypeptide binding]; other site 431943010543 Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642 431943010544 Divergent AAA domain; Region: AAA_4; pfam04326 431943010545 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 431943010546 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 431943010547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943010548 non-specific DNA binding site [nucleotide binding]; other site 431943010549 salt bridge; other site 431943010550 sequence-specific DNA binding site [nucleotide binding]; other site 431943010551 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 431943010552 Coenzyme A binding pocket [chemical binding]; other site 431943010553 YbaK / prolyl-tRNA synthetases associated domain; Region: YbaK; pfam04073 431943010554 putative deacylase active site [active] 431943010555 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 431943010556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943010557 active site 431943010558 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 431943010559 AAA domain; Region: AAA_30; pfam13604 431943010560 Family description; Region: UvrD_C_2; pfam13538 431943010561 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943010562 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943010563 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 431943010564 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 431943010565 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 431943010566 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 431943010567 intersubunit interface [polypeptide binding]; other site 431943010568 S-adenosylmethionine synthetase; Validated; Region: PRK05250 431943010569 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 431943010570 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 431943010571 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 431943010572 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 431943010573 rod shape-determining protein Mbl; Provisional; Region: PRK13928 431943010574 MreB and similar proteins; Region: MreB_like; cd10225 431943010575 nucleotide binding site [chemical binding]; other site 431943010576 Mg binding site [ion binding]; other site 431943010577 putative protofilament interaction site [polypeptide binding]; other site 431943010578 RodZ interaction site [polypeptide binding]; other site 431943010579 Stage III sporulation protein D; Region: SpoIIID; pfam12116 431943010580 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 431943010581 Peptidase family M23; Region: Peptidase_M23; pfam01551 431943010582 stage II sporulation protein D; Region: spore_II_D; TIGR02870 431943010583 Stage II sporulation protein; Region: SpoIID; pfam08486 431943010584 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 431943010585 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 431943010586 hinge; other site 431943010587 active site 431943010588 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 431943010589 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 431943010590 gamma subunit interface [polypeptide binding]; other site 431943010591 epsilon subunit interface [polypeptide binding]; other site 431943010592 LBP interface [polypeptide binding]; other site 431943010593 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 431943010594 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 431943010595 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 431943010596 alpha subunit interaction interface [polypeptide binding]; other site 431943010597 Walker A motif; other site 431943010598 ATP binding site [chemical binding]; other site 431943010599 Walker B motif; other site 431943010600 inhibitor binding site; inhibition site 431943010601 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 431943010602 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 431943010603 core domain interface [polypeptide binding]; other site 431943010604 delta subunit interface [polypeptide binding]; other site 431943010605 epsilon subunit interface [polypeptide binding]; other site 431943010606 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 431943010607 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 431943010608 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 431943010609 beta subunit interaction interface [polypeptide binding]; other site 431943010610 Walker A motif; other site 431943010611 ATP binding site [chemical binding]; other site 431943010612 Walker B motif; other site 431943010613 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 431943010614 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 431943010615 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 431943010616 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 431943010617 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 431943010618 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 431943010619 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 431943010620 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 431943010621 putative acyltransferase; Provisional; Region: PRK05790 431943010622 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 431943010623 dimer interface [polypeptide binding]; other site 431943010624 active site 431943010625 putative acyltransferase; Provisional; Region: PRK05790 431943010626 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 431943010627 dimer interface [polypeptide binding]; other site 431943010628 active site 431943010629 putative acyltransferase; Provisional; Region: PRK05790 431943010630 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 431943010631 dimer interface [polypeptide binding]; other site 431943010632 active site 431943010633 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 431943010634 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 431943010635 active site 431943010636 homodimer interface [polypeptide binding]; other site 431943010637 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 431943010638 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 431943010639 Mg++ binding site [ion binding]; other site 431943010640 putative catalytic motif [active] 431943010641 substrate binding site [chemical binding]; other site 431943010642 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 431943010643 catalytic motif [active] 431943010644 Zn binding site [ion binding]; other site 431943010645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 431943010646 active site 431943010647 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 431943010648 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 431943010649 Low molecular weight phosphatase family; Region: LMWPc; cd00115 431943010650 active site 431943010651 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 431943010652 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 431943010653 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 431943010654 peptide chain release factor 1; Validated; Region: prfA; PRK00591 431943010655 This domain is found in peptide chain release factors; Region: PCRF; smart00937 431943010656 RF-1 domain; Region: RF-1; pfam00472 431943010657 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 431943010658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943010659 S-adenosylmethionine binding site [chemical binding]; other site 431943010660 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 431943010661 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 431943010662 transcription termination factor Rho; Provisional; Region: PRK12608 431943010663 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 431943010664 RNA binding site [nucleotide binding]; other site 431943010665 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 431943010666 multimer interface [polypeptide binding]; other site 431943010667 Walker A motif; other site 431943010668 ATP binding site [chemical binding]; other site 431943010669 Walker B motif; other site 431943010670 CTP synthetase; Validated; Region: pyrG; PRK05380 431943010671 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 431943010672 Catalytic site [active] 431943010673 active site 431943010674 UTP binding site [chemical binding]; other site 431943010675 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 431943010676 active site 431943010677 putative oxyanion hole; other site 431943010678 catalytic triad [active] 431943010679 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 431943010680 germination protein YpeB; Region: spore_YpeB; TIGR02889 431943010681 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 431943010682 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 431943010683 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 431943010684 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 431943010685 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 431943010686 Spore germination protein; Region: Spore_permease; cl17796 431943010687 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 431943010688 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 431943010689 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 431943010690 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 431943010691 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 431943010692 cyanophycin synthetase; Provisional; Region: PRK14016 431943010693 ATP-grasp domain; Region: ATP-grasp_4; cl17255 431943010694 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 431943010695 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 431943010696 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 431943010697 proposed catalytic triad [active] 431943010698 active site nucleophile [active] 431943010699 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 431943010700 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 431943010701 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 431943010702 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 431943010703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 431943010704 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 431943010705 YabG peptidase U57; Region: Peptidase_U57; pfam05582 431943010706 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 431943010707 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 431943010708 active site 431943010709 ATP binding site [chemical binding]; other site 431943010710 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 431943010711 substrate binding site [chemical binding]; other site 431943010712 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 431943010713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943010714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943010715 dimerization interface [polypeptide binding]; other site 431943010716 putative DNA binding site [nucleotide binding]; other site 431943010717 putative Zn2+ binding site [ion binding]; other site 431943010718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 431943010719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 431943010720 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943010721 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943010722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010723 Walker A/P-loop; other site 431943010724 ATP binding site [chemical binding]; other site 431943010725 Q-loop/lid; other site 431943010726 ABC transporter signature motif; other site 431943010727 Walker B; other site 431943010728 D-loop; other site 431943010729 H-loop/switch region; other site 431943010730 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 431943010731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 431943010732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943010733 Walker A/P-loop; other site 431943010734 ATP binding site [chemical binding]; other site 431943010735 Q-loop/lid; other site 431943010736 ABC transporter signature motif; other site 431943010737 Walker B; other site 431943010738 D-loop; other site 431943010739 H-loop/switch region; other site 431943010740 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943010741 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943010742 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 431943010743 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 431943010744 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 431943010745 substrate binding site [chemical binding]; other site 431943010746 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 431943010747 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 431943010748 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 431943010749 active site 431943010750 ATP binding site [chemical binding]; other site 431943010751 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 431943010752 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 431943010753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 431943010754 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 431943010755 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 431943010756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943010757 FeS/SAM binding site; other site 431943010758 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 431943010759 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 431943010760 active site 431943010761 DNA binding site [nucleotide binding] 431943010762 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 431943010763 GIY-YIG motif/motif A; other site 431943010764 putative active site [active] 431943010765 putative metal binding site [ion binding]; other site 431943010766 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 431943010767 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 431943010768 Substrate binding site; other site 431943010769 Cupin domain; Region: Cupin_2; cl17218 431943010770 AAA domain; Region: AAA_11; pfam13086 431943010771 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 431943010772 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 431943010773 AAA domain; Region: AAA_12; pfam13087 431943010774 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 431943010775 putative active site [active] 431943010776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 431943010777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 431943010778 phosphoenolpyruvate synthase; Validated; Region: PRK06241 431943010779 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 431943010780 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 431943010781 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 431943010782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 431943010783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 431943010784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 431943010785 DNA binding site [nucleotide binding] 431943010786 domain linker motif; other site 431943010787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 431943010788 dimerization interface [polypeptide binding]; other site 431943010789 ligand binding site [chemical binding]; other site 431943010790 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 431943010791 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 431943010792 HIGH motif; other site 431943010793 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 431943010794 active site 431943010795 KMSKS motif; other site 431943010796 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 431943010797 tRNA binding surface [nucleotide binding]; other site 431943010798 anticodon binding site; other site 431943010799 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 431943010800 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 431943010801 active site 431943010802 metal binding site [ion binding]; metal-binding site 431943010803 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 431943010804 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 431943010805 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 431943010806 active site 431943010807 metal binding site [ion binding]; metal-binding site 431943010808 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 431943010809 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 431943010810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 431943010811 dimerization interface [polypeptide binding]; other site 431943010812 putative DNA binding site [nucleotide binding]; other site 431943010813 putative Zn2+ binding site [ion binding]; other site 431943010814 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 431943010815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943010816 FeS/SAM binding site; other site 431943010817 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 431943010818 ATP cone domain; Region: ATP-cone; pfam03477 431943010819 Class III ribonucleotide reductase; Region: RNR_III; cd01675 431943010820 effector binding site; other site 431943010821 active site 431943010822 Zn binding site [ion binding]; other site 431943010823 glycine loop; other site 431943010824 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 431943010825 OsmC-like protein; Region: OsmC; cl00767 431943010826 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 431943010827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943010828 S-adenosylmethionine binding site [chemical binding]; other site 431943010829 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 431943010830 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 431943010831 putative active site [active] 431943010832 putative metal binding site [ion binding]; other site 431943010833 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 431943010834 Domain of unknown function (DUF348); Region: DUF348; pfam03990 431943010835 Domain of unknown function (DUF348); Region: DUF348; pfam03990 431943010836 G5 domain; Region: G5; pfam07501 431943010837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 431943010838 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 431943010839 active site 431943010840 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 431943010841 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 431943010842 HIGH motif; other site 431943010843 active site 431943010844 KMSKS motif; other site 431943010845 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 431943010846 tRNA binding surface [nucleotide binding]; other site 431943010847 anticodon binding site; other site 431943010848 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 431943010849 dimer interface [polypeptide binding]; other site 431943010850 putative tRNA-binding site [nucleotide binding]; other site 431943010851 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 431943010852 Fe-S cluster binding site [ion binding]; other site 431943010853 active site 431943010854 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 431943010855 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 431943010856 Bacterial Ig-like domain; Region: Big_5; pfam13205 431943010857 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 431943010858 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 431943010859 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 431943010860 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 431943010861 putative active site [active] 431943010862 putative metal binding site [ion binding]; other site 431943010863 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 431943010864 homotrimer interaction site [polypeptide binding]; other site 431943010865 zinc binding site [ion binding]; other site 431943010866 CDP-binding sites; other site 431943010867 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 431943010868 HSF-type DNA-binding; Region: HSF_DNA-bind; cl12113 431943010869 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 431943010870 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943010871 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943010872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943010873 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 431943010874 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 431943010875 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 431943010876 non-heme iron binding site [ion binding]; other site 431943010877 dimer interface [polypeptide binding]; other site 431943010878 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 431943010879 non-heme iron binding site [ion binding]; other site 431943010880 dimer interface [polypeptide binding]; other site 431943010881 Rubrerythrin [Energy production and conversion]; Region: COG1592 431943010882 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 431943010883 binuclear metal center [ion binding]; other site 431943010884 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 431943010885 iron binding site [ion binding]; other site 431943010886 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 431943010887 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 431943010888 active site 431943010889 NTP binding site [chemical binding]; other site 431943010890 metal binding triad [ion binding]; metal-binding site 431943010891 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 431943010892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 431943010893 Zn2+ binding site [ion binding]; other site 431943010894 Mg2+ binding site [ion binding]; other site 431943010895 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 431943010896 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 431943010897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 431943010898 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 431943010899 NlpC/P60 family; Region: NLPC_P60; pfam00877 431943010900 Predicted methyltransferases [General function prediction only]; Region: COG0313 431943010901 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 431943010902 putative SAM binding site [chemical binding]; other site 431943010903 putative homodimer interface [polypeptide binding]; other site 431943010904 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 431943010905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943010906 S-adenosylmethionine binding site [chemical binding]; other site 431943010907 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 431943010908 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 431943010909 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 431943010910 ligand binding site [chemical binding]; other site 431943010911 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 431943010912 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 431943010913 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943010914 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 431943010915 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 431943010916 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 431943010917 DNA polymerase III subunit delta'; Validated; Region: PRK05564 431943010918 DNA polymerase III subunit delta'; Validated; Region: PRK08485 431943010919 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 431943010920 Protein of unknown function (DUF970); Region: DUF970; cl17525 431943010921 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 431943010922 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 431943010923 TMP-binding site; other site 431943010924 ATP-binding site [chemical binding]; other site 431943010925 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 431943010926 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 431943010927 homodimer interface [polypeptide binding]; other site 431943010928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 431943010929 catalytic residue [active] 431943010930 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 431943010931 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 431943010932 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 431943010933 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 431943010934 Cl binding site [ion binding]; other site 431943010935 oligomer interface [polypeptide binding]; other site 431943010936 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 431943010937 dimer interface [polypeptide binding]; other site 431943010938 catalytic triad [active] 431943010939 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 431943010940 NAD-dependent deacetylase; Provisional; Region: PRK00481 431943010941 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 431943010942 NAD+ binding site [chemical binding]; other site 431943010943 substrate binding site [chemical binding]; other site 431943010944 Zn binding site [ion binding]; other site 431943010945 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 431943010946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943010947 catalytic residue [active] 431943010948 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 431943010949 Fe-S cluster binding site [ion binding]; other site 431943010950 active site 431943010951 Predicted integral membrane protein [Function unknown]; Region: COG5652 431943010952 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 431943010953 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 431943010954 oligomer interface [polypeptide binding]; other site 431943010955 active site 431943010956 metal binding site [ion binding]; metal-binding site 431943010957 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 431943010958 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 431943010959 oligomer interface [polypeptide binding]; other site 431943010960 active site 431943010961 metal binding site [ion binding]; metal-binding site 431943010962 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 431943010963 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 431943010964 oligomer interface [polypeptide binding]; other site 431943010965 active site 431943010966 metal binding site [ion binding]; metal-binding site 431943010967 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 431943010968 Uncharacterized conserved protein [Function unknown]; Region: COG4198 431943010969 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 431943010970 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 431943010971 putative ligand binding site [chemical binding]; other site 431943010972 NAD binding site [chemical binding]; other site 431943010973 dimerization interface [polypeptide binding]; other site 431943010974 catalytic site [active] 431943010975 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 431943010976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 431943010977 catalytic residue [active] 431943010978 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 431943010979 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 431943010980 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 431943010981 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 431943010982 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 431943010983 putative NADH binding site [chemical binding]; other site 431943010984 putative active site [active] 431943010985 nudix motif; other site 431943010986 putative metal binding site [ion binding]; other site 431943010987 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 431943010988 recombination protein RecR; Reviewed; Region: recR; PRK00076 431943010989 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 431943010990 helix-hairpin-helix signature motif; other site 431943010991 RecR protein; Region: RecR; pfam02132 431943010992 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 431943010993 putative active site [active] 431943010994 putative metal-binding site [ion binding]; other site 431943010995 tetramer interface [polypeptide binding]; other site 431943010996 hypothetical protein; Validated; Region: PRK00153 431943010997 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 431943010998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943010999 Walker A motif; other site 431943011000 ATP binding site [chemical binding]; other site 431943011001 Walker B motif; other site 431943011002 arginine finger; other site 431943011003 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 431943011004 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 431943011005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 431943011006 FeS/SAM binding site; other site 431943011007 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 431943011008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943011009 S-adenosylmethionine binding site [chemical binding]; other site 431943011010 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943011011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943011012 catalytic residues [active] 431943011013 Recombinase; Region: Recombinase; pfam07508 431943011014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943011015 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 431943011016 Walker A motif; other site 431943011017 ATP binding site [chemical binding]; other site 431943011018 Walker B motif; other site 431943011019 arginine finger; other site 431943011020 Transposase; Region: DEDD_Tnp_IS110; pfam01548 431943011021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 431943011022 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 431943011023 FRG domain; Region: FRG; pfam08867 431943011024 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943011025 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943011026 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943011027 catalytic residues [active] 431943011028 Recombinase; Region: Recombinase; pfam07508 431943011029 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943011030 Recombinase; Region: Recombinase; pfam07508 431943011031 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943011032 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943011033 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943011034 catalytic residues [active] 431943011035 catalytic nucleophile [active] 431943011036 Recombinase; Region: Recombinase; pfam07508 431943011037 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 431943011038 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 431943011039 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 431943011040 catalytic residues [active] 431943011041 catalytic nucleophile [active] 431943011042 PemK-like protein; Region: PemK; pfam02452 431943011043 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 431943011044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 431943011045 DNA binding residues [nucleotide binding] 431943011046 Predicted transcriptional regulators [Transcription]; Region: COG1725 431943011047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 431943011048 DNA-binding site [nucleotide binding]; DNA binding site 431943011049 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 431943011050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943011051 Walker A/P-loop; other site 431943011052 ATP binding site [chemical binding]; other site 431943011053 Q-loop/lid; other site 431943011054 ABC transporter signature motif; other site 431943011055 Walker B; other site 431943011056 D-loop; other site 431943011057 H-loop/switch region; other site 431943011058 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 431943011059 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943011060 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 431943011061 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 431943011062 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 431943011063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 431943011064 Walker A/P-loop; other site 431943011065 ATP binding site [chemical binding]; other site 431943011066 Q-loop/lid; other site 431943011067 ABC transporter signature motif; other site 431943011068 Walker B; other site 431943011069 D-loop; other site 431943011070 H-loop/switch region; other site 431943011071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 431943011072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 431943011073 dimer interface [polypeptide binding]; other site 431943011074 phosphorylation site [posttranslational modification] 431943011075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 431943011076 ATP binding site [chemical binding]; other site 431943011077 Mg2+ binding site [ion binding]; other site 431943011078 G-X-G motif; other site 431943011079 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 431943011080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 431943011081 active site 431943011082 phosphorylation site [posttranslational modification] 431943011083 intermolecular recognition site; other site 431943011084 dimerization interface [polypeptide binding]; other site 431943011085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 431943011086 DNA binding site [nucleotide binding] 431943011087 Helix-turn-helix domain; Region: HTH_17; pfam12728 431943011088 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 431943011089 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 431943011090 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 431943011091 Methyltransferase domain; Region: Methyltransf_31; pfam13847 431943011092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 431943011093 S-adenosylmethionine binding site [chemical binding]; other site 431943011094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 431943011095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 431943011096 non-specific DNA binding site [nucleotide binding]; other site 431943011097 salt bridge; other site 431943011098 sequence-specific DNA binding site [nucleotide binding]; other site 431943011099 Helix-turn-helix domain; Region: HTH_36; pfam13730 431943011100 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 431943011101 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 431943011102 Walker A motif; other site 431943011103 ATP binding site [chemical binding]; other site 431943011104 Walker B motif; other site 431943011105 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 431943011106 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 431943011107 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 431943011108 active site 431943011109 metal binding site [ion binding]; metal-binding site 431943011110 interdomain interaction site; other site 431943011111 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 431943011112 Sel1-like repeats; Region: SEL1; smart00671 431943011113 Sel1-like repeats; Region: SEL1; smart00671 431943011114 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 431943011115 Sel1-like repeats; Region: SEL1; smart00671 431943011116 Sel1-like repeats; Region: SEL1; smart00671 431943011117 Sel1-like repeats; Region: SEL1; smart00671 431943011118 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 431943011119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 431943011120 DNA binding residues [nucleotide binding] 431943011121 dimer interface [polypeptide binding]; other site 431943011122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943011123 Coenzyme A binding pocket [chemical binding]; other site 431943011124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 431943011125 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 431943011126 Coenzyme A binding pocket [chemical binding]; other site 431943011127 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 431943011128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 431943011129 Peptidase family M23; Region: Peptidase_M23; pfam01551 431943011130 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 431943011131 putative active site pocket [active] 431943011132 dimerization interface [polypeptide binding]; other site 431943011133 putative catalytic residue [active] 431943011134 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 431943011135 AAA-like domain; Region: AAA_10; pfam12846 431943011136 Domain of unknown function DUF87; Region: DUF87; pfam01935 431943011137 SnoaL-like domain; Region: SnoaL_2; pfam12680 431943011138 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 431943011139 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 431943011140 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 431943011141 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 431943011142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 431943011143 Walker A motif; other site 431943011144 ATP binding site [chemical binding]; other site 431943011145 Walker B motif; other site 431943011146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 431943011147 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 431943011148 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 431943011149 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 431943011150 SpoVG; Region: SpoVG; pfam04026 431943011151 YodL-like; Region: YodL; pfam14191 431943011152 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 431943011153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 431943011154 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 431943011155 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 431943011156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 431943011157 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 431943011158 putative dimer interface [polypeptide binding]; other site 431943011159 replicative DNA helicase; Provisional; Region: PRK05595 431943011160 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 431943011161 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 431943011162 Walker A motif; other site 431943011163 ATP binding site [chemical binding]; other site 431943011164 Walker B motif; other site 431943011165 DNA binding loops [nucleotide binding] 431943011166 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 431943011167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 431943011168 Walker A motif; other site 431943011169 ATP binding site [chemical binding]; other site 431943011170 Walker B motif; other site 431943011171 arginine finger; other site 431943011172 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 431943011173 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 431943011174 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 431943011175 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 431943011176 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 431943011177 DHH family; Region: DHH; pfam01368 431943011178 DHHA1 domain; Region: DHHA1; pfam02272 431943011179 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 431943011180 MazG-like family; Region: MazG-like; pfam12643 431943011181 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 431943011182 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 431943011183 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 431943011184 dimer interface [polypeptide binding]; other site 431943011185 ssDNA binding site [nucleotide binding]; other site 431943011186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 431943011187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 431943011188 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 431943011189 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 431943011190 Mechanosensitive ion channel; Region: MS_channel; pfam00924 431943011191 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 431943011192 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 431943011193 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 431943011194 ParB-like nuclease domain; Region: ParBc; pfam02195 431943011195 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 431943011196 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 431943011197 Magnesium ion binding site [ion binding]; other site 431943011198 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 431943011199 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 431943011200 putative active site [active] 431943011201 putative NTP binding site [chemical binding]; other site 431943011202 putative nucleic acid binding site [nucleotide binding]; other site 431943011203 Type II intron maturase; Region: Intron_maturas2; pfam01348 431943011204 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 431943011205 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 431943011206 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 431943011207 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 431943011208 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 431943011209 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 431943011210 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 431943011211 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 431943011212 trmE is a tRNA modification GTPase; Region: trmE; cd04164 431943011213 G1 box; other site 431943011214 GTP/Mg2+ binding site [chemical binding]; other site 431943011215 Switch I region; other site 431943011216 G2 box; other site 431943011217 Switch II region; other site 431943011218 G3 box; other site 431943011219 G4 box; other site 431943011220 G5 box; other site 431943011221 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 431943011222 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 431943011223 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 431943011224 G-X-X-G motif; other site 431943011225 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 431943011226 RxxxH motif; other site 431943011227 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 431943011228 Haemolytic domain; Region: Haemolytic; pfam01809 431943011229 ribonuclease P; Reviewed; Region: rnpA; PRK00499 431943011230 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399