-- dump date 20140619_044657 -- class Genbank::misc_feature -- table misc_feature_note -- id note 748727000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 748727000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 748727000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727000004 Walker A motif; other site 748727000005 ATP binding site [chemical binding]; other site 748727000006 Walker B motif; other site 748727000007 arginine finger; other site 748727000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 748727000009 DnaA box-binding interface [nucleotide binding]; other site 748727000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 748727000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 748727000012 putative DNA binding surface [nucleotide binding]; other site 748727000013 dimer interface [polypeptide binding]; other site 748727000014 beta-clamp/clamp loader binding surface; other site 748727000015 beta-clamp/translesion DNA polymerase binding surface; other site 748727000016 S4 domain; Region: S4_2; pfam13275 748727000017 recombination protein F; Reviewed; Region: recF; PRK00064 748727000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 748727000019 Walker A/P-loop; other site 748727000020 ATP binding site [chemical binding]; other site 748727000021 Q-loop/lid; other site 748727000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727000023 ABC transporter signature motif; other site 748727000024 Walker B; other site 748727000025 D-loop; other site 748727000026 H-loop/switch region; other site 748727000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 748727000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727000029 Mg2+ binding site [ion binding]; other site 748727000030 G-X-G motif; other site 748727000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748727000032 anchoring element; other site 748727000033 dimer interface [polypeptide binding]; other site 748727000034 ATP binding site [chemical binding]; other site 748727000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 748727000036 active site 748727000037 putative metal-binding site [ion binding]; other site 748727000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748727000039 DNA gyrase subunit A; Validated; Region: PRK05560 748727000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748727000041 CAP-like domain; other site 748727000042 active site 748727000043 primary dimer interface [polypeptide binding]; other site 748727000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727000050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727000051 Zn2+ binding site [ion binding]; other site 748727000052 Mg2+ binding site [ion binding]; other site 748727000053 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 748727000054 HTH domain; Region: HTH_11; pfam08279 748727000055 3H domain; Region: 3H; pfam02829 748727000056 hypothetical protein; Validated; Region: PRK00068 748727000057 Uncharacterized conserved protein [Function unknown]; Region: COG1615 748727000058 hydroxyglutarate oxidase; Provisional; Region: PRK11728 748727000059 FAD dependent oxidoreductase; Region: DAO; pfam01266 748727000060 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 748727000061 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 748727000062 seryl-tRNA synthetase; Provisional; Region: PRK05431 748727000063 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 748727000064 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 748727000065 dimer interface [polypeptide binding]; other site 748727000066 active site 748727000067 motif 1; other site 748727000068 motif 2; other site 748727000069 motif 3; other site 748727000070 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 748727000071 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 748727000072 Int/Topo IB signature motif; other site 748727000073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727000074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727000075 non-specific DNA binding site [nucleotide binding]; other site 748727000076 salt bridge; other site 748727000077 sequence-specific DNA binding site [nucleotide binding]; other site 748727000078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727000079 non-specific DNA binding site [nucleotide binding]; other site 748727000080 salt bridge; other site 748727000081 sequence-specific DNA binding site [nucleotide binding]; other site 748727000082 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 748727000083 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 748727000084 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 748727000085 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748727000086 DNA binding residues [nucleotide binding] 748727000087 Terminase small subunit; Region: Terminase_2; pfam03592 748727000088 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 748727000089 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 748727000090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748727000091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748727000092 catalytic residue [active] 748727000093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727000094 non-specific DNA binding site [nucleotide binding]; other site 748727000095 salt bridge; other site 748727000096 sequence-specific DNA binding site [nucleotide binding]; other site 748727000097 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748727000098 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748727000099 Virulence protein [General function prediction only]; Region: COG3943 748727000100 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 748727000101 Coat F domain; Region: Coat_F; pfam07875 748727000102 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 748727000103 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727000104 MarR family; Region: MarR_2; pfam12802 748727000105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727000106 Coenzyme A binding pocket [chemical binding]; other site 748727000107 Transcriptional regulator [Transcription]; Region: IclR; COG1414 748727000108 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 748727000109 Bacterial transcriptional regulator; Region: IclR; pfam01614 748727000110 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 748727000111 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 748727000112 inhibitor site; inhibition site 748727000113 active site 748727000114 dimer interface [polypeptide binding]; other site 748727000115 catalytic residue [active] 748727000116 putative dehydratase; Provisional; Region: PRK08211 748727000117 Dehydratase family; Region: ILVD_EDD; cl00340 748727000118 fructuronate transporter; Provisional; Region: PRK10034; cl15264 748727000119 gluconate transporter; Region: gntP; TIGR00791 748727000120 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 748727000121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727000122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727000123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727000124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 748727000125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727000126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748727000127 active site 748727000128 motif I; other site 748727000129 motif II; other site 748727000130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748727000131 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 748727000132 intersubunit interface [polypeptide binding]; other site 748727000133 active site 748727000134 zinc binding site [ion binding]; other site 748727000135 Na+ binding site [ion binding]; other site 748727000136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 748727000137 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 748727000138 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 748727000139 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 748727000140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727000141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727000142 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 748727000143 ABC1 family; Region: ABC1; cl17513 748727000144 Uncharacterized conserved protein [Function unknown]; Region: COG3937 748727000145 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 748727000146 nucleoside/Zn binding site; other site 748727000147 dimer interface [polypeptide binding]; other site 748727000148 catalytic motif [active] 748727000149 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727000150 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727000151 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 748727000152 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727000153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727000154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727000155 Walker A/P-loop; other site 748727000156 ATP binding site [chemical binding]; other site 748727000157 Q-loop/lid; other site 748727000158 ABC transporter signature motif; other site 748727000159 Walker B; other site 748727000160 D-loop; other site 748727000161 H-loop/switch region; other site 748727000162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727000163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727000164 dimer interface [polypeptide binding]; other site 748727000165 phosphorylation site [posttranslational modification] 748727000166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727000167 ATP binding site [chemical binding]; other site 748727000168 Mg2+ binding site [ion binding]; other site 748727000169 G-X-G motif; other site 748727000170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727000172 active site 748727000173 phosphorylation site [posttranslational modification] 748727000174 intermolecular recognition site; other site 748727000175 dimerization interface [polypeptide binding]; other site 748727000176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727000177 DNA binding site [nucleotide binding] 748727000178 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727000179 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 748727000180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727000181 Walker A motif; other site 748727000182 ATP binding site [chemical binding]; other site 748727000183 Walker B motif; other site 748727000184 arginine finger; other site 748727000185 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 748727000186 hypothetical protein; Validated; Region: PRK00153 748727000187 recombination protein RecR; Reviewed; Region: recR; PRK00076 748727000188 RecR protein; Region: RecR; pfam02132 748727000189 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 748727000190 putative active site [active] 748727000191 putative metal-binding site [ion binding]; other site 748727000192 tetramer interface [polypeptide binding]; other site 748727000193 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 748727000194 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 748727000195 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 748727000196 putative NADH binding site [chemical binding]; other site 748727000197 putative active site [active] 748727000198 nudix motif; other site 748727000199 putative metal binding site [ion binding]; other site 748727000200 Class I aldolases; Region: Aldolase_Class_I; cl17187 748727000201 catalytic residue [active] 748727000202 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727000203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727000204 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727000205 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 748727000206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727000207 catalytic residue [active] 748727000208 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 748727000209 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 748727000210 putative ligand binding site [chemical binding]; other site 748727000211 NAD binding site [chemical binding]; other site 748727000212 dimerization interface [polypeptide binding]; other site 748727000213 catalytic site [active] 748727000214 Uncharacterized conserved protein [Function unknown]; Region: COG4198 748727000215 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 748727000216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 748727000217 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 748727000218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727000219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727000220 Zn2+ binding site [ion binding]; other site 748727000221 Mg2+ binding site [ion binding]; other site 748727000222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727000223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727000224 active site 748727000225 phosphorylation site [posttranslational modification] 748727000226 intermolecular recognition site; other site 748727000227 dimerization interface [polypeptide binding]; other site 748727000228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727000229 DNA binding site [nucleotide binding] 748727000230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727000231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727000232 dimer interface [polypeptide binding]; other site 748727000233 phosphorylation site [posttranslational modification] 748727000234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727000235 ATP binding site [chemical binding]; other site 748727000236 Mg2+ binding site [ion binding]; other site 748727000237 G-X-G motif; other site 748727000238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727000239 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727000240 Walker A/P-loop; other site 748727000241 ATP binding site [chemical binding]; other site 748727000242 Q-loop/lid; other site 748727000243 ABC transporter signature motif; other site 748727000244 Walker B; other site 748727000245 D-loop; other site 748727000246 H-loop/switch region; other site 748727000247 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727000248 FtsX-like permease family; Region: FtsX; pfam02687 748727000249 FtsX-like permease family; Region: FtsX; pfam02687 748727000250 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748727000251 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748727000252 oligomer interface [polypeptide binding]; other site 748727000253 active site 748727000254 metal binding site [ion binding]; metal-binding site 748727000255 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748727000256 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748727000257 oligomer interface [polypeptide binding]; other site 748727000258 active site 748727000259 metal binding site [ion binding]; metal-binding site 748727000260 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748727000261 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748727000262 oligomer interface [polypeptide binding]; other site 748727000263 active site 748727000264 metal binding site [ion binding]; metal-binding site 748727000265 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 748727000266 active site 748727000267 Fe-S cluster binding site [ion binding]; other site 748727000268 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 748727000269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727000270 catalytic residue [active] 748727000271 SurA N-terminal domain; Region: SurA_N_3; cl07813 748727000272 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 748727000273 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 748727000274 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 748727000275 active site 748727000276 catalytic residues [active] 748727000277 L-arabinose isomerase; Provisional; Region: PRK02929 748727000278 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 748727000279 hexamer (dimer of trimers) interface [polypeptide binding]; other site 748727000280 trimer interface [polypeptide binding]; other site 748727000281 substrate binding site [chemical binding]; other site 748727000282 Mn binding site [ion binding]; other site 748727000283 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 748727000284 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 748727000285 intersubunit interface [polypeptide binding]; other site 748727000286 active site 748727000287 Zn2+ binding site [ion binding]; other site 748727000288 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 748727000289 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 748727000290 putative N- and C-terminal domain interface [polypeptide binding]; other site 748727000291 putative active site [active] 748727000292 MgATP binding site [chemical binding]; other site 748727000293 catalytic site [active] 748727000294 metal binding site [ion binding]; metal-binding site 748727000295 putative carbohydrate binding site [chemical binding]; other site 748727000296 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748727000297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727000298 DNA-binding site [nucleotide binding]; DNA binding site 748727000299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748727000300 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 748727000301 putative dimerization interface [polypeptide binding]; other site 748727000302 putative ligand binding site [chemical binding]; other site 748727000303 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 748727000304 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 748727000305 MFS/sugar transport protein; Region: MFS_2; pfam13347 748727000306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727000307 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 748727000308 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 748727000309 ligand binding site [chemical binding]; other site 748727000310 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 748727000311 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748727000312 Walker A/P-loop; other site 748727000313 ATP binding site [chemical binding]; other site 748727000314 Q-loop/lid; other site 748727000315 ABC transporter signature motif; other site 748727000316 Walker B; other site 748727000317 D-loop; other site 748727000318 H-loop/switch region; other site 748727000319 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748727000320 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727000321 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 748727000322 TM-ABC transporter signature motif; other site 748727000323 NAD-dependent deacetylase; Provisional; Region: PRK00481 748727000324 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 748727000325 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 748727000326 dimer interface [polypeptide binding]; other site 748727000327 catalytic triad [active] 748727000328 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 748727000329 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 748727000330 Cl binding site [ion binding]; other site 748727000331 oligomer interface [polypeptide binding]; other site 748727000332 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 748727000333 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 748727000334 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 748727000335 homodimer interface [polypeptide binding]; other site 748727000336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727000337 catalytic residue [active] 748727000338 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 748727000339 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 748727000340 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 748727000341 TMP-binding site; other site 748727000342 ATP-binding site [chemical binding]; other site 748727000343 Protein of unknown function (DUF970); Region: DUF970; pfam06153 748727000344 DNA polymerase III subunit delta'; Validated; Region: PRK05564 748727000345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748727000346 Walker A motif; other site 748727000347 ATP binding site [chemical binding]; other site 748727000348 DNA polymerase III subunit delta'; Validated; Region: PRK08485 748727000349 Walker B motif; other site 748727000350 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 748727000351 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 748727000352 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 748727000353 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727000354 4Fe-4S binding domain; Region: Fer4; cl02805 748727000355 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 748727000356 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 748727000357 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 748727000358 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 748727000359 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 748727000360 ligand binding site [chemical binding]; other site 748727000361 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 748727000362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727000363 S-adenosylmethionine binding site [chemical binding]; other site 748727000364 Predicted methyltransferases [General function prediction only]; Region: COG0313 748727000365 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 748727000366 putative SAM binding site [chemical binding]; other site 748727000367 putative homodimer interface [polypeptide binding]; other site 748727000368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 748727000369 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748727000370 NlpC/P60 family; Region: NLPC_P60; pfam00877 748727000371 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748727000372 NlpC/P60 family; Region: NLPC_P60; pfam00877 748727000373 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 748727000374 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 748727000375 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 748727000376 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 748727000377 active site 748727000378 NTP binding site [chemical binding]; other site 748727000379 metal binding triad [ion binding]; metal-binding site 748727000380 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 748727000381 CRISPR-associated endonuclease Cas3-HD; Region: cas3_HD; TIGR01596 748727000382 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 748727000383 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 748727000384 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 748727000385 homotrimer interaction site [polypeptide binding]; other site 748727000386 zinc binding site [ion binding]; other site 748727000387 CDP-binding sites; other site 748727000388 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727000389 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727000390 NodB motif; other site 748727000391 active site 748727000392 catalytic site [active] 748727000393 Zn binding site [ion binding]; other site 748727000394 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727000395 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 748727000396 putative active site [active] 748727000397 putative metal binding site [ion binding]; other site 748727000398 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727000399 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 748727000400 B3/4 domain; Region: B3_4; pfam03483 748727000401 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 748727000402 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 748727000403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748727000404 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748727000405 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748727000406 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727000407 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 748727000408 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 748727000409 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 748727000410 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 748727000411 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 748727000412 Fe-S cluster binding site [ion binding]; other site 748727000413 active site 748727000414 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 748727000415 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 748727000416 HIGH motif; other site 748727000417 active site 748727000418 KMSKS motif; other site 748727000419 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 748727000420 anticodon binding site; other site 748727000421 tRNA binding surface [nucleotide binding]; other site 748727000422 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 748727000423 putative tRNA-binding site [nucleotide binding]; other site 748727000424 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 748727000425 active site 748727000426 Domain of unknown function (DUF348); Region: DUF348; pfam03990 748727000427 Domain of unknown function (DUF348); Region: DUF348; pfam03990 748727000428 G5 domain; Region: G5; pfam07501 748727000429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 748727000430 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 748727000431 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 748727000432 putative active site [active] 748727000433 putative metal binding site [ion binding]; other site 748727000434 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 748727000435 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 748727000436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727000437 S-adenosylmethionine binding site [chemical binding]; other site 748727000438 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 748727000439 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 748727000440 Walker A motif; other site 748727000441 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 748727000442 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 748727000443 ATP cone domain; Region: ATP-cone; pfam03477 748727000444 Class III ribonucleotide reductase; Region: RNR_III; cd01675 748727000445 effector binding site; other site 748727000446 active site 748727000447 Zn binding site [ion binding]; other site 748727000448 glycine loop; other site 748727000449 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 748727000450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727000451 FeS/SAM binding site; other site 748727000452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727000453 dimerization interface [polypeptide binding]; other site 748727000454 putative DNA binding site [nucleotide binding]; other site 748727000455 putative Zn2+ binding site [ion binding]; other site 748727000456 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 748727000457 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 748727000458 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727000459 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748727000460 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748727000461 active site 748727000462 metal binding site [ion binding]; metal-binding site 748727000463 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727000464 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748727000465 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748727000466 active site 748727000467 metal binding site [ion binding]; metal-binding site 748727000468 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 748727000469 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 748727000470 HIGH motif; other site 748727000471 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 748727000472 active site 748727000473 KMSKS motif; other site 748727000474 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 748727000475 tRNA binding surface [nucleotide binding]; other site 748727000476 anticodon binding site; other site 748727000477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748727000478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748727000479 DNA binding site [nucleotide binding] 748727000480 domain linker motif; other site 748727000481 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 748727000482 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748727000483 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748727000484 Part of AAA domain; Region: AAA_19; pfam13245 748727000485 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 748727000486 AAA domain; Region: AAA_12; pfam13087 748727000487 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 748727000488 putative active site [active] 748727000489 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 748727000490 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 748727000491 Substrate binding site; other site 748727000492 Cupin domain; Region: Cupin_2; cl17218 748727000493 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 748727000494 GIY-YIG motif/motif A; other site 748727000495 putative active site [active] 748727000496 putative metal binding site [ion binding]; other site 748727000497 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 748727000498 active site 748727000499 DNA binding site [nucleotide binding] 748727000500 Protein of unknown function DUF111; Region: DUF111; pfam01969 748727000501 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 748727000502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727000503 FeS/SAM binding site; other site 748727000504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748727000505 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748727000506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727000507 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 748727000508 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 748727000509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 748727000510 active site 748727000511 ATP binding site [chemical binding]; other site 748727000512 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 748727000513 substrate binding site [chemical binding]; other site 748727000514 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 748727000515 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 748727000516 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 748727000517 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 748727000518 substrate binding site [chemical binding]; other site 748727000519 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 748727000520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727000521 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 748727000522 spore coat protein YutH; Region: spore_yutH; TIGR02905 748727000523 YabG peptidase U57; Region: Peptidase_U57; pfam05582 748727000524 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 748727000525 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748727000526 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748727000527 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748727000528 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748727000529 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727000530 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 748727000531 proposed catalytic triad [active] 748727000532 active site nucleophile [active] 748727000533 cyanophycin synthetase; Provisional; Region: PRK14016 748727000534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727000535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727000536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748727000537 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 748727000538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748727000539 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727000540 Spore germination protein; Region: Spore_permease; cl17796 748727000541 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727000542 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727000543 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727000544 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 748727000545 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 748727000546 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 748727000547 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727000548 germination protein YpeB; Region: spore_YpeB; TIGR02889 748727000549 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 748727000550 CTP synthetase; Validated; Region: pyrG; PRK05380 748727000551 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 748727000552 Catalytic site [active] 748727000553 active site 748727000554 UTP binding site [chemical binding]; other site 748727000555 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 748727000556 active site 748727000557 putative oxyanion hole; other site 748727000558 catalytic triad [active] 748727000559 transcription termination factor Rho; Provisional; Region: rho; PRK09376 748727000560 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 748727000561 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 748727000562 RNA binding site [nucleotide binding]; other site 748727000563 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 748727000564 multimer interface [polypeptide binding]; other site 748727000565 Walker A motif; other site 748727000566 ATP binding site [chemical binding]; other site 748727000567 Walker B motif; other site 748727000568 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 748727000569 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 748727000570 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 748727000571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727000572 S-adenosylmethionine binding site [chemical binding]; other site 748727000573 peptide chain release factor 1; Validated; Region: prfA; PRK00591 748727000574 Protein of unknown function (DUF964); Region: DUF964; cl01483 748727000575 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748727000576 RF-1 domain; Region: RF-1; pfam00472 748727000577 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 748727000578 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 748727000579 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 748727000580 Low molecular weight phosphatase family; Region: LMWPc; cd00115 748727000581 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 748727000582 active site 748727000583 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 748727000584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727000585 active site 748727000586 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 748727000587 catalytic motif [active] 748727000588 Zn binding site [ion binding]; other site 748727000589 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 748727000590 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 748727000591 Mg++ binding site [ion binding]; other site 748727000592 putative catalytic motif [active] 748727000593 substrate binding site [chemical binding]; other site 748727000594 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 748727000595 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 748727000596 active site 748727000597 homodimer interface [polypeptide binding]; other site 748727000598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 748727000599 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 748727000600 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 748727000601 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 748727000602 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 748727000603 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 748727000604 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 748727000605 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748727000606 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 748727000607 beta subunit interaction interface [polypeptide binding]; other site 748727000608 Walker A motif; other site 748727000609 ATP binding site [chemical binding]; other site 748727000610 Walker B motif; other site 748727000611 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748727000612 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 748727000613 core domain interface [polypeptide binding]; other site 748727000614 delta subunit interface [polypeptide binding]; other site 748727000615 epsilon subunit interface [polypeptide binding]; other site 748727000616 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 748727000617 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748727000618 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 748727000619 alpha subunit interaction interface [polypeptide binding]; other site 748727000620 Walker A motif; other site 748727000621 ATP binding site [chemical binding]; other site 748727000622 Walker B motif; other site 748727000623 inhibitor binding site; inhibition site 748727000624 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748727000625 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 748727000626 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 748727000627 gamma subunit interface [polypeptide binding]; other site 748727000628 epsilon subunit interface [polypeptide binding]; other site 748727000629 LBP interface [polypeptide binding]; other site 748727000630 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 748727000631 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 748727000632 hinge; other site 748727000633 active site 748727000634 stage II sporulation protein D; Region: spore_II_D; TIGR02870 748727000635 Stage II sporulation protein; Region: SpoIID; pfam08486 748727000636 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 748727000637 Peptidase family M23; Region: Peptidase_M23; pfam01551 748727000638 Stage III sporulation protein D; Region: SpoIIID; pfam12116 748727000639 rod shape-determining protein Mbl; Provisional; Region: PRK13928 748727000640 MreB and similar proteins; Region: MreB_like; cd10225 748727000641 nucleotide binding site [chemical binding]; other site 748727000642 Mg binding site [ion binding]; other site 748727000643 putative protofilament interaction site [polypeptide binding]; other site 748727000644 RodZ interaction site [polypeptide binding]; other site 748727000645 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 748727000646 S-adenosylmethionine synthetase; Validated; Region: PRK05250 748727000647 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 748727000648 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 748727000649 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 748727000650 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 748727000651 AAA domain; Region: AAA_30; pfam13604 748727000652 Family description; Region: UvrD_C_2; pfam13538 748727000653 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 748727000654 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 748727000655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727000656 active site 748727000657 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 748727000658 30S subunit binding site; other site 748727000659 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 748727000660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748727000661 ATP binding site [chemical binding]; other site 748727000662 putative Mg++ binding site [ion binding]; other site 748727000663 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 748727000664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727000665 nucleotide binding region [chemical binding]; other site 748727000666 ATP-binding site [chemical binding]; other site 748727000667 SEC-C motif; Region: SEC-C; pfam02810 748727000668 peptide chain release factor 2; Provisional; Region: PRK05589 748727000669 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748727000670 RF-1 domain; Region: RF-1; pfam00472 748727000671 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727000672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727000673 putative substrate translocation pore; other site 748727000674 glutamate dehydrogenase; Provisional; Region: PRK09414 748727000675 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 748727000676 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 748727000677 NAD(P) binding site [chemical binding]; other site 748727000678 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748727000679 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 748727000680 Peptidase family M28; Region: Peptidase_M28; pfam04389 748727000681 metal binding site [ion binding]; metal-binding site 748727000682 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 748727000683 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 748727000684 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 748727000685 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 748727000686 RNA binding site [nucleotide binding]; other site 748727000687 Predicted membrane protein [Function unknown]; Region: COG3601 748727000688 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748727000689 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 748727000690 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 748727000691 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727000692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 748727000693 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 748727000694 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748727000695 synthetase active site [active] 748727000696 NTP binding site [chemical binding]; other site 748727000697 metal binding site [ion binding]; metal-binding site 748727000698 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 748727000699 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 748727000700 HIGH motif; other site 748727000701 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748727000702 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748727000703 active site 748727000704 KMSKS motif; other site 748727000705 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 748727000706 tRNA binding surface [nucleotide binding]; other site 748727000707 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 748727000708 HSP70 interaction site [polypeptide binding]; other site 748727000709 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 748727000710 putative active site [active] 748727000711 putative triphosphate binding site [ion binding]; other site 748727000712 dimer interface [polypeptide binding]; other site 748727000713 putative metal binding residues [ion binding]; other site 748727000714 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 748727000715 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 748727000716 intersubunit interface [polypeptide binding]; other site 748727000717 active site 748727000718 zinc binding site [ion binding]; other site 748727000719 Na+ binding site [ion binding]; other site 748727000720 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 748727000721 Predicted membrane protein [Function unknown]; Region: COG2323 748727000722 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 748727000723 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 748727000724 active site 748727000725 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 748727000726 AIR carboxylase; Region: AIRC; smart01001 748727000727 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 748727000728 anti sigma factor interaction site; other site 748727000729 regulatory phosphorylation site [posttranslational modification]; other site 748727000730 Cache domain; Region: Cache_1; pfam02743 748727000731 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727000732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727000733 dimerization interface [polypeptide binding]; other site 748727000734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727000735 dimer interface [polypeptide binding]; other site 748727000736 putative CheW interface [polypeptide binding]; other site 748727000737 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 748727000738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 748727000739 ATP binding site [chemical binding]; other site 748727000740 Mg2+ binding site [ion binding]; other site 748727000741 G-X-G motif; other site 748727000742 PAS domain; Region: PAS; smart00091 748727000743 PAS domain; Region: PAS_9; pfam13426 748727000744 PAS domain S-box; Region: sensory_box; TIGR00229 748727000745 PAS domain; Region: PAS; smart00091 748727000746 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 748727000747 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 748727000748 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 748727000749 Uncharacterized conserved protein [Function unknown]; Region: COG0398 748727000750 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748727000751 FOG: CBS domain [General function prediction only]; Region: COG0517 748727000752 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 748727000753 putative lipid kinase; Reviewed; Region: PRK13059 748727000754 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 748727000755 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 748727000756 hypothetical protein; Provisional; Region: PRK00955 748727000757 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 748727000758 MgtE intracellular N domain; Region: MgtE_N; smart00924 748727000759 FOG: CBS domain [General function prediction only]; Region: COG0517 748727000760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 748727000761 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 748727000762 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727000763 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748727000764 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 748727000765 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 748727000766 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 748727000767 putative substrate binding site [chemical binding]; other site 748727000768 putative ATP binding site [chemical binding]; other site 748727000769 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 748727000770 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 748727000771 PemK-like protein; Region: PemK; pfam02452 748727000772 transketolase; Reviewed; Region: PRK05899 748727000773 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748727000774 TPP-binding site [chemical binding]; other site 748727000775 dimer interface [polypeptide binding]; other site 748727000776 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 748727000777 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748727000778 PYR/PP interface [polypeptide binding]; other site 748727000779 dimer interface [polypeptide binding]; other site 748727000780 TPP binding site [chemical binding]; other site 748727000781 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748727000782 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 748727000783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727000784 Walker A/P-loop; other site 748727000785 ATP binding site [chemical binding]; other site 748727000786 Q-loop/lid; other site 748727000787 ABC transporter signature motif; other site 748727000788 Walker B; other site 748727000789 D-loop; other site 748727000790 H-loop/switch region; other site 748727000791 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 748727000792 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 748727000793 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 748727000794 C-terminal peptidase (prc); Region: prc; TIGR00225 748727000795 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 748727000796 protein binding site [polypeptide binding]; other site 748727000797 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 748727000798 Catalytic dyad [active] 748727000799 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 748727000800 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748727000801 excinuclease ABC subunit B; Provisional; Region: PRK05298 748727000802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727000803 ATP binding site [chemical binding]; other site 748727000804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748727000805 putative Mg++ binding site [ion binding]; other site 748727000806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727000807 nucleotide binding region [chemical binding]; other site 748727000808 ATP-binding site [chemical binding]; other site 748727000809 Ultra-violet resistance protein B; Region: UvrB; pfam12344 748727000810 UvrB/uvrC motif; Region: UVR; pfam02151 748727000811 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 748727000812 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748727000813 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748727000814 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 748727000815 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 748727000816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 748727000817 phosphopeptide binding site; other site 748727000818 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 748727000819 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727000820 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748727000821 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 748727000822 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 748727000823 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 748727000824 GIY-YIG motif/motif A; other site 748727000825 active site 748727000826 catalytic site [active] 748727000827 putative DNA binding site [nucleotide binding]; other site 748727000828 metal binding site [ion binding]; metal-binding site 748727000829 UvrB/uvrC motif; Region: UVR; pfam02151 748727000830 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 748727000831 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 748727000832 FAD binding domain; Region: FAD_binding_4; pfam01565 748727000833 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 748727000834 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 748727000835 AAA domain; Region: AAA_18; pfam13238 748727000836 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 748727000837 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 748727000838 phosphate binding site [ion binding]; other site 748727000839 putative substrate binding pocket [chemical binding]; other site 748727000840 dimer interface [polypeptide binding]; other site 748727000841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 748727000842 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 748727000843 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 748727000844 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 748727000845 active site 748727000846 PHP Thumb interface [polypeptide binding]; other site 748727000847 metal binding site [ion binding]; metal-binding site 748727000848 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 748727000849 generic binding surface II; other site 748727000850 generic binding surface I; other site 748727000851 6-phosphofructokinase; Provisional; Region: PRK03202 748727000852 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 748727000853 active site 748727000854 ADP/pyrophosphate binding site [chemical binding]; other site 748727000855 dimerization interface [polypeptide binding]; other site 748727000856 allosteric effector site; other site 748727000857 fructose-1,6-bisphosphate binding site; other site 748727000858 pyruvate kinase; Provisional; Region: PRK06354 748727000859 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 748727000860 domain interfaces; other site 748727000861 active site 748727000862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 748727000863 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 748727000864 TRAM domain; Region: TRAM; cl01282 748727000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727000866 S-adenosylmethionine binding site [chemical binding]; other site 748727000867 Recombinase; Region: Recombinase; pfam07508 748727000868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 748727000869 HsdM N-terminal domain; Region: HsdM_N; pfam12161 748727000870 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 748727000871 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748727000872 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 748727000873 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 748727000874 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 748727000875 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 748727000876 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 748727000877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727000878 ATP binding site [chemical binding]; other site 748727000879 putative Mg++ binding site [ion binding]; other site 748727000880 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 748727000881 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748727000882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727000883 DNA binding residues [nucleotide binding] 748727000884 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 748727000885 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 748727000886 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 748727000887 active site 748727000888 DNA binding site [nucleotide binding] 748727000889 catalytic site [active] 748727000890 Prophage antirepressor [Transcription]; Region: COG3617 748727000891 BRO family, N-terminal domain; Region: Bro-N; smart01040 748727000892 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 748727000893 Virulence-associated protein E; Region: VirE; pfam05272 748727000894 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 748727000895 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 748727000896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727000897 ATP binding site [chemical binding]; other site 748727000898 putative Mg++ binding site [ion binding]; other site 748727000899 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 748727000900 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748727000901 active site 748727000902 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 748727000903 ParB-like nuclease domain; Region: ParB; smart00470 748727000904 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 748727000905 DNA methylase; Region: N6_N4_Mtase; pfam01555 748727000906 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 748727000907 Phage terminase, small subunit; Region: Terminase_4; pfam05119 748727000908 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 748727000909 Phage-related protein [Function unknown]; Region: COG4695 748727000910 Phage portal protein; Region: Phage_portal; pfam04860 748727000911 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 748727000912 oligomer interface [polypeptide binding]; other site 748727000913 Clp protease; Region: CLP_protease; pfam00574 748727000914 active site residues [active] 748727000915 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 748727000916 Phage capsid family; Region: Phage_capsid; pfam05065 748727000917 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 748727000918 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 748727000919 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 748727000920 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 748727000921 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 748727000922 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 748727000923 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 748727000924 Phage-related protein [Function unknown]; Region: COG5412 748727000925 Phage-related protein [Function unknown]; Region: COG4722 748727000926 Phage tail protein; Region: Sipho_tail; cl17486 748727000927 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 748727000928 hypothetical protein; Provisional; Region: PRK14013 748727000929 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 748727000930 amidase catalytic site [active] 748727000931 Zn binding residues [ion binding]; other site 748727000932 substrate binding site [chemical binding]; other site 748727000933 Bacterial SH3 domain; Region: SH3_3; pfam08239 748727000934 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 748727000935 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 748727000936 catalytic residues [active] 748727000937 catalytic nucleophile [active] 748727000938 Recombinase; Region: Recombinase; pfam07508 748727000939 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 748727000940 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 748727000941 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 748727000942 catalytic residues [active] 748727000943 catalytic nucleophile [active] 748727000944 Recombinase; Region: Recombinase; pfam07508 748727000945 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 748727000946 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 748727000947 nucleophile elbow; other site 748727000948 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 748727000949 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 748727000950 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 748727000951 Propionate catabolism activator; Region: PrpR_N; pfam06506 748727000952 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748727000953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727000954 Walker A motif; other site 748727000955 ATP binding site [chemical binding]; other site 748727000956 Walker B motif; other site 748727000957 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727000958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 748727000959 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727000960 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 748727000961 putative active site [active] 748727000962 metal binding site [ion binding]; metal-binding site 748727000963 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 748727000964 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 748727000965 inhibitor site; inhibition site 748727000966 active site 748727000967 dimer interface [polypeptide binding]; other site 748727000968 catalytic residue [active] 748727000969 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 748727000970 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 748727000971 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 748727000972 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 748727000973 putative ligand binding site [chemical binding]; other site 748727000974 putative NAD binding site [chemical binding]; other site 748727000975 catalytic site [active] 748727000976 D-galactonate transporter; Region: 2A0114; TIGR00893 748727000977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727000978 putative substrate translocation pore; other site 748727000979 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 748727000980 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748727000981 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727000982 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727000983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727000984 dimer interface [polypeptide binding]; other site 748727000985 putative CheW interface [polypeptide binding]; other site 748727000986 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 748727000987 EamA-like transporter family; Region: EamA; pfam00892 748727000988 EamA-like transporter family; Region: EamA; pfam00892 748727000989 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727000990 HAMP domain; Region: HAMP; pfam00672 748727000991 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727000992 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727000993 dimer interface [polypeptide binding]; other site 748727000994 putative CheW interface [polypeptide binding]; other site 748727000995 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 748727000996 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 748727000997 Ligand binding site; other site 748727000998 Putative Catalytic site; other site 748727000999 DXD motif; other site 748727001000 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 748727001001 Predicted integral membrane protein [Function unknown]; Region: COG5617 748727001002 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 748727001003 putative ligand binding site [chemical binding]; other site 748727001004 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 748727001005 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 748727001006 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 748727001007 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 748727001008 DXD motif; other site 748727001009 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727001010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727001011 metal binding site [ion binding]; metal-binding site 748727001012 active site 748727001013 I-site; other site 748727001014 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 748727001015 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 748727001016 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 748727001017 Nitrogen regulatory protein P-II; Region: P-II; smart00938 748727001018 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 748727001019 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 748727001020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 748727001021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727001022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727001023 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748727001024 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727001025 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727001026 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 748727001027 Methyltransferase domain; Region: Methyltransf_11; pfam08241 748727001028 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 748727001029 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 748727001030 ATP binding site [chemical binding]; other site 748727001031 Mg++ binding site [ion binding]; other site 748727001032 motif III; other site 748727001033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727001034 nucleotide binding region [chemical binding]; other site 748727001035 ATP-binding site [chemical binding]; other site 748727001036 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 748727001037 RNA binding site [nucleotide binding]; other site 748727001038 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 748727001039 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727001040 Zn2+ binding site [ion binding]; other site 748727001041 Mg2+ binding site [ion binding]; other site 748727001042 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 748727001043 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 748727001044 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 748727001045 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 748727001046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 748727001047 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 748727001048 putative DNA binding site [nucleotide binding]; other site 748727001049 putative Zn2+ binding site [ion binding]; other site 748727001050 AsnC family; Region: AsnC_trans_reg; pfam01037 748727001051 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 748727001052 Malic enzyme, N-terminal domain; Region: malic; pfam00390 748727001053 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 748727001054 putative NAD(P) binding site [chemical binding]; other site 748727001055 aspartate ammonia-lyase; Provisional; Region: PRK13353 748727001056 Aspartase; Region: Aspartase; cd01357 748727001057 active sites [active] 748727001058 tetramer interface [polypeptide binding]; other site 748727001059 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748727001060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727001061 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727001062 putative CheW interface [polypeptide binding]; other site 748727001063 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748727001064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727001065 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 748727001066 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 748727001067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727001068 active site 748727001069 motif I; other site 748727001070 motif II; other site 748727001071 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748727001072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727001073 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 748727001074 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 748727001075 dimer interface [polypeptide binding]; other site 748727001076 active site 748727001077 catalytic residue [active] 748727001078 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 748727001079 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 748727001080 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 748727001081 SpoVR like protein; Region: SpoVR; pfam04293 748727001082 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 748727001083 metal ion-dependent adhesion site (MIDAS); other site 748727001084 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 748727001085 AAA ATPase domain; Region: AAA_16; pfam13191 748727001086 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 748727001087 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727001088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727001089 putative Zn2+ binding site [ion binding]; other site 748727001090 putative DNA binding site [nucleotide binding]; other site 748727001091 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 748727001092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727001093 putative substrate translocation pore; other site 748727001094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727001095 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 748727001096 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727001097 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727001098 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727001099 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727001100 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 748727001101 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 748727001102 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 748727001103 catalytic site [active] 748727001104 subunit interface [polypeptide binding]; other site 748727001105 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 748727001106 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727001107 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748727001108 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748727001109 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727001110 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727001111 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 748727001112 IMP binding site; other site 748727001113 dimer interface [polypeptide binding]; other site 748727001114 interdomain contacts; other site 748727001115 partial ornithine binding site; other site 748727001116 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748727001117 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 748727001118 metal binding site [ion binding]; metal-binding site 748727001119 dimer interface [polypeptide binding]; other site 748727001120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001121 dimer interface [polypeptide binding]; other site 748727001122 phosphorylation site [posttranslational modification] 748727001123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001124 ATP binding site [chemical binding]; other site 748727001125 Mg2+ binding site [ion binding]; other site 748727001126 G-X-G motif; other site 748727001127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727001128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727001129 active site 748727001130 phosphorylation site [posttranslational modification] 748727001131 intermolecular recognition site; other site 748727001132 dimerization interface [polypeptide binding]; other site 748727001133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727001134 DNA binding site [nucleotide binding] 748727001135 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 748727001136 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 748727001137 Ligand binding site; other site 748727001138 Putative Catalytic site; other site 748727001139 DXD motif; other site 748727001140 Predicted membrane protein [Function unknown]; Region: COG2246 748727001141 GtrA-like protein; Region: GtrA; pfam04138 748727001142 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 748727001143 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 748727001144 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 748727001145 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 748727001146 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 748727001147 tRNA; other site 748727001148 putative tRNA binding site [nucleotide binding]; other site 748727001149 putative NADP binding site [chemical binding]; other site 748727001150 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 748727001151 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 748727001152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748727001153 inhibitor-cofactor binding pocket; inhibition site 748727001154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727001155 catalytic residue [active] 748727001156 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 748727001157 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 748727001158 active site 748727001159 tetramer interface; other site 748727001160 Predicted integral membrane protein [Function unknown]; Region: COG5542 748727001161 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 748727001162 putative metal binding site; other site 748727001163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727001164 binding surface 748727001165 TPR motif; other site 748727001166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 748727001167 binding surface 748727001168 TPR motif; other site 748727001169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727001170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001171 dimer interface [polypeptide binding]; other site 748727001172 phosphorylation site [posttranslational modification] 748727001173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001174 ATP binding site [chemical binding]; other site 748727001175 Mg2+ binding site [ion binding]; other site 748727001176 G-X-G motif; other site 748727001177 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727001178 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 748727001179 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727001180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727001181 Walker A/P-loop; other site 748727001182 ATP binding site [chemical binding]; other site 748727001183 Q-loop/lid; other site 748727001184 ABC transporter signature motif; other site 748727001185 Walker B; other site 748727001186 D-loop; other site 748727001187 H-loop/switch region; other site 748727001188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727001189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727001190 active site 748727001191 phosphorylation site [posttranslational modification] 748727001192 intermolecular recognition site; other site 748727001193 dimerization interface [polypeptide binding]; other site 748727001194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727001195 DNA binding site [nucleotide binding] 748727001196 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 748727001197 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 748727001198 Walker A/P-loop; other site 748727001199 ATP binding site [chemical binding]; other site 748727001200 Q-loop/lid; other site 748727001201 ABC transporter signature motif; other site 748727001202 Walker B; other site 748727001203 D-loop; other site 748727001204 H-loop/switch region; other site 748727001205 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 748727001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727001207 dimer interface [polypeptide binding]; other site 748727001208 conserved gate region; other site 748727001209 ABC-ATPase subunit interface; other site 748727001210 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 748727001211 Predicted transcriptional regulators [Transcription]; Region: COG1725 748727001212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727001213 DNA-binding site [nucleotide binding]; DNA binding site 748727001214 Predicted membrane protein [General function prediction only]; Region: COG4194 748727001215 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 748727001216 aspartate aminotransferase; Provisional; Region: PRK06836 748727001217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727001218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727001219 homodimer interface [polypeptide binding]; other site 748727001220 catalytic residue [active] 748727001221 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727001222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727001223 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748727001224 Protein of unknown function DUF116; Region: DUF116; pfam01976 748727001225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727001226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727001227 putative substrate translocation pore; other site 748727001228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727001229 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727001230 MarR family; Region: MarR_2; cl17246 748727001231 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 748727001232 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727001234 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727001235 putative substrate translocation pore; other site 748727001236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 748727001237 active site 748727001238 ATP binding site [chemical binding]; other site 748727001239 amino acid transporter; Region: 2A0306; TIGR00909 748727001240 Spore germination protein; Region: Spore_permease; cl17796 748727001241 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727001242 amino acid transporter; Region: 2A0306; TIGR00909 748727001243 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727001244 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727001245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727001246 dimerization interface [polypeptide binding]; other site 748727001247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727001248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727001249 dimer interface [polypeptide binding]; other site 748727001250 putative CheW interface [polypeptide binding]; other site 748727001251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727001252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001253 dimer interface [polypeptide binding]; other site 748727001254 phosphorylation site [posttranslational modification] 748727001255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001256 ATP binding site [chemical binding]; other site 748727001257 Mg2+ binding site [ion binding]; other site 748727001258 G-X-G motif; other site 748727001259 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 748727001260 Ligand Binding Site [chemical binding]; other site 748727001261 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748727001262 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001263 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001264 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001265 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001266 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001267 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001268 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748727001269 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727001270 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 748727001271 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 748727001272 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 748727001273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727001274 active site 748727001275 metal binding site [ion binding]; metal-binding site 748727001276 homotetramer interface [polypeptide binding]; other site 748727001277 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 748727001278 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748727001279 Peptidase M16C associated; Region: M16C_assoc; pfam08367 748727001280 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727001281 PBP superfamily domain; Region: PBP_like; pfam12727 748727001282 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 748727001283 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 748727001284 Nucleotide-binding sites [chemical binding]; other site 748727001285 Walker A motif; other site 748727001286 Switch I region of nucleotide binding site; other site 748727001287 Fe4S4 binding sites [ion binding]; other site 748727001288 Switch II region of nucleotide binding site; other site 748727001289 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 748727001290 Nitrogen regulatory protein P-II; Region: P-II; smart00938 748727001291 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 748727001292 Nitrogen regulatory protein P-II; Region: P-II; smart00938 748727001293 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727001294 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 748727001295 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727001296 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727001297 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 748727001298 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 748727001299 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727001300 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727001301 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 748727001302 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 748727001303 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 748727001304 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 748727001305 active site 748727001306 catalytic residues [active] 748727001307 metal binding site [ion binding]; metal-binding site 748727001308 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001309 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001310 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001311 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001312 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001313 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727001315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727001316 active site 748727001317 phosphorylation site [posttranslational modification] 748727001318 intermolecular recognition site; other site 748727001319 dimerization interface [polypeptide binding]; other site 748727001320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727001321 DNA binding site [nucleotide binding] 748727001322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727001323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727001324 dimerization interface [polypeptide binding]; other site 748727001325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001326 dimer interface [polypeptide binding]; other site 748727001327 phosphorylation site [posttranslational modification] 748727001328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001329 ATP binding site [chemical binding]; other site 748727001330 Mg2+ binding site [ion binding]; other site 748727001331 G-X-G motif; other site 748727001332 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727001333 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727001334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727001335 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727001336 Walker A/P-loop; other site 748727001337 ATP binding site [chemical binding]; other site 748727001338 Q-loop/lid; other site 748727001339 ABC transporter signature motif; other site 748727001340 Walker B; other site 748727001341 D-loop; other site 748727001342 H-loop/switch region; other site 748727001343 Outer membrane efflux protein; Region: OEP; pfam02321 748727001344 Outer membrane efflux protein; Region: OEP; pfam02321 748727001345 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 748727001346 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727001347 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001348 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001349 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001350 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001351 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001352 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001353 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 748727001354 Chain length determinant protein; Region: Wzz; cl15801 748727001355 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 748727001356 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 748727001357 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727001358 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 748727001359 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 748727001360 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748727001361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727001362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 748727001363 DNA binding residues [nucleotide binding] 748727001364 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 748727001365 Bacterial sugar transferase; Region: Bac_transf; pfam02397 748727001366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001367 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 748727001368 putative ADP-binding pocket [chemical binding]; other site 748727001369 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 748727001370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001371 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 748727001372 O-Antigen ligase; Region: Wzy_C; pfam04932 748727001373 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748727001374 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 748727001375 Probable Catalytic site; other site 748727001376 metal-binding site 748727001377 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748727001378 active site 748727001379 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 748727001380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 748727001381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001382 putative homodimer interface [polypeptide binding]; other site 748727001383 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748727001384 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 748727001385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001386 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727001387 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 748727001388 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 748727001389 Probable Catalytic site; other site 748727001390 metal-binding site 748727001391 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 748727001392 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 748727001393 Substrate binding site; other site 748727001394 Cupin domain; Region: Cupin_2; cl17218 748727001395 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 748727001396 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 748727001397 NAD binding site [chemical binding]; other site 748727001398 substrate binding site [chemical binding]; other site 748727001399 homodimer interface [polypeptide binding]; other site 748727001400 active site 748727001401 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 748727001402 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 748727001403 substrate binding site; other site 748727001404 tetramer interface; other site 748727001405 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 748727001406 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 748727001407 NADP binding site [chemical binding]; other site 748727001408 active site 748727001409 putative substrate binding site [chemical binding]; other site 748727001410 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 748727001411 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 748727001412 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 748727001413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 748727001414 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 748727001415 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 748727001416 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 748727001417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 748727001418 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 748727001419 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 748727001420 Bacterial sugar transferase; Region: Bac_transf; pfam02397 748727001421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001422 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 748727001423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001424 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 748727001425 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748727001426 putative trimer interface [polypeptide binding]; other site 748727001427 putative CoA binding site [chemical binding]; other site 748727001428 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 748727001429 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748727001430 Ligand Binding Site [chemical binding]; other site 748727001431 Molecular Tunnel; other site 748727001432 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 748727001433 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 748727001434 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 748727001435 NAD(P) binding site [chemical binding]; other site 748727001436 homodimer interface [polypeptide binding]; other site 748727001437 substrate binding site [chemical binding]; other site 748727001438 active site 748727001439 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 748727001440 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 748727001441 inhibitor-cofactor binding pocket; inhibition site 748727001442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727001443 catalytic residue [active] 748727001444 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 748727001445 ligand binding site; other site 748727001446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748727001447 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 748727001448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 748727001449 pseudaminic acid synthase; Region: PseI; TIGR03586 748727001450 NeuB family; Region: NeuB; pfam03102 748727001451 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 748727001452 NeuB binding interface [polypeptide binding]; other site 748727001453 putative substrate binding site [chemical binding]; other site 748727001454 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 748727001455 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727001456 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 748727001457 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748727001458 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 748727001459 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 748727001460 Substrate binding site; other site 748727001461 Cupin domain; Region: Cupin_2; cl17218 748727001462 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 748727001463 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 748727001464 NAD binding site [chemical binding]; other site 748727001465 substrate binding site [chemical binding]; other site 748727001466 homodimer interface [polypeptide binding]; other site 748727001467 active site 748727001468 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 748727001469 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 748727001470 substrate binding site; other site 748727001471 tetramer interface; other site 748727001472 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 748727001473 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 748727001474 NADP binding site [chemical binding]; other site 748727001475 active site 748727001476 putative substrate binding site [chemical binding]; other site 748727001477 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 748727001478 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727001479 metal binding site [ion binding]; metal-binding site 748727001480 active site 748727001481 I-site; other site 748727001482 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727001483 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 748727001484 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 748727001485 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 748727001486 MgtC family; Region: MgtC; pfam02308 748727001487 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001488 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 748727001489 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001490 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727001492 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 748727001493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727001494 FtsX-like permease family; Region: FtsX; pfam02687 748727001495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727001496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727001497 Walker A/P-loop; other site 748727001498 ATP binding site [chemical binding]; other site 748727001499 Q-loop/lid; other site 748727001500 ABC transporter signature motif; other site 748727001501 Walker B; other site 748727001502 D-loop; other site 748727001503 H-loop/switch region; other site 748727001504 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748727001505 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 748727001506 metal ion-dependent adhesion site (MIDAS); other site 748727001507 Tubulin like; Region: Tubulin_2; pfam13809 748727001508 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 748727001509 metal ion-dependent adhesion site (MIDAS); other site 748727001510 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 748727001511 Double zinc ribbon; Region: DZR; pfam12773 748727001512 YARHG domain; Region: YARHG; pfam13308 748727001513 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727001514 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 748727001515 putative binding site residues; other site 748727001516 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748727001517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748727001518 ABC-ATPase subunit interface; other site 748727001519 dimer interface [polypeptide binding]; other site 748727001520 putative PBP binding regions; other site 748727001521 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748727001522 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748727001523 Walker A/P-loop; other site 748727001524 ATP binding site [chemical binding]; other site 748727001525 Q-loop/lid; other site 748727001526 ABC transporter signature motif; other site 748727001527 Walker B; other site 748727001528 D-loop; other site 748727001529 H-loop/switch region; other site 748727001530 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 748727001531 Domain of unknown function DUF; Region: DUF204; pfam02659 748727001532 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727001533 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727001534 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 748727001535 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 748727001536 active site 748727001537 Ion channel; Region: Ion_trans_2; pfam07885 748727001538 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 748727001539 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 748727001540 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001541 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001542 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727001543 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 748727001544 FAD binding domain; Region: FAD_binding_4; pfam01565 748727001545 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 748727001546 Predicted integral membrane protein [Function unknown]; Region: COG5652 748727001547 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 748727001548 ADP-ribose binding site [chemical binding]; other site 748727001549 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727001550 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727001551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748727001552 active site 748727001553 metal binding site [ion binding]; metal-binding site 748727001554 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748727001555 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748727001556 Catalytic site [active] 748727001557 gamma-glutamyl kinase; Provisional; Region: PRK05429 748727001558 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 748727001559 nucleotide binding site [chemical binding]; other site 748727001560 homotetrameric interface [polypeptide binding]; other site 748727001561 putative phosphate binding site [ion binding]; other site 748727001562 putative allosteric binding site; other site 748727001563 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 748727001564 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 748727001565 putative catalytic cysteine [active] 748727001566 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 748727001567 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 748727001568 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727001569 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 748727001570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748727001571 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727001572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727001573 dimer interface [polypeptide binding]; other site 748727001574 putative CheW interface [polypeptide binding]; other site 748727001575 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 748727001576 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 748727001577 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 748727001578 protein binding site [polypeptide binding]; other site 748727001579 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 748727001580 Catalytic dyad [active] 748727001581 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727001582 Protein of unknown function DUF45; Region: DUF45; pfam01863 748727001583 Predicted membrane protein [Function unknown]; Region: COG1971 748727001584 Domain of unknown function DUF; Region: DUF204; pfam02659 748727001585 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727001586 metal binding site 2 [ion binding]; metal-binding site 748727001587 putative DNA binding helix; other site 748727001588 metal binding site 1 [ion binding]; metal-binding site 748727001589 dimer interface [polypeptide binding]; other site 748727001590 structural Zn2+ binding site [ion binding]; other site 748727001591 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727001592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727001593 Zn2+ binding site [ion binding]; other site 748727001594 Mg2+ binding site [ion binding]; other site 748727001595 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 748727001596 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 748727001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727001598 Walker A motif; other site 748727001599 ATP binding site [chemical binding]; other site 748727001600 Walker B motif; other site 748727001601 arginine finger; other site 748727001602 Peptidase family M41; Region: Peptidase_M41; pfam01434 748727001603 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 748727001604 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 748727001605 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 748727001606 RNA/DNA hybrid binding site [nucleotide binding]; other site 748727001607 active site 748727001608 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727001609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727001610 non-specific DNA binding site [nucleotide binding]; other site 748727001611 salt bridge; other site 748727001612 sequence-specific DNA binding site [nucleotide binding]; other site 748727001613 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727001614 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727001615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727001616 non-specific DNA binding site [nucleotide binding]; other site 748727001617 salt bridge; other site 748727001618 sequence-specific DNA binding site [nucleotide binding]; other site 748727001619 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 748727001620 Clp amino terminal domain; Region: Clp_N; pfam02861 748727001621 Clp amino terminal domain; Region: Clp_N; pfam02861 748727001622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727001623 Walker A motif; other site 748727001624 ATP binding site [chemical binding]; other site 748727001625 Walker B motif; other site 748727001626 arginine finger; other site 748727001627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727001628 Walker A motif; other site 748727001629 ATP binding site [chemical binding]; other site 748727001630 Walker B motif; other site 748727001631 arginine finger; other site 748727001632 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748727001633 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727001634 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727001635 NodB motif; other site 748727001636 active site 748727001637 catalytic site [active] 748727001638 Zn binding site [ion binding]; other site 748727001639 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 748727001640 catalytic triad [active] 748727001641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727001642 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 748727001643 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 748727001644 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 748727001645 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 748727001646 active site 748727001647 substrate-binding site [chemical binding]; other site 748727001648 metal-binding site [ion binding] 748727001649 ATP binding site [chemical binding]; other site 748727001650 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 748727001651 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748727001652 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 748727001653 metal binding site [ion binding]; metal-binding site 748727001654 dimer interface [polypeptide binding]; other site 748727001655 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 748727001656 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 748727001657 Walker A/P-loop; other site 748727001658 ATP binding site [chemical binding]; other site 748727001659 Q-loop/lid; other site 748727001660 ABC transporter signature motif; other site 748727001661 Walker B; other site 748727001662 D-loop; other site 748727001663 H-loop/switch region; other site 748727001664 NIL domain; Region: NIL; pfam09383 748727001665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727001666 dimer interface [polypeptide binding]; other site 748727001667 conserved gate region; other site 748727001668 ABC-ATPase subunit interface; other site 748727001669 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 748727001670 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 748727001671 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727001672 EamA-like transporter family; Region: EamA; pfam00892 748727001673 EamA-like transporter family; Region: EamA; pfam00892 748727001674 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 748727001675 dihydropteroate synthase; Region: DHPS; TIGR01496 748727001676 substrate binding pocket [chemical binding]; other site 748727001677 dimer interface [polypeptide binding]; other site 748727001678 inhibitor binding site; inhibition site 748727001679 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 748727001680 homodecamer interface [polypeptide binding]; other site 748727001681 GTP cyclohydrolase I; Provisional; Region: PLN03044 748727001682 active site 748727001683 putative catalytic site residues [active] 748727001684 zinc binding site [ion binding]; other site 748727001685 GTP-CH-I/GFRP interaction surface; other site 748727001686 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 748727001687 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 748727001688 homooctamer interface [polypeptide binding]; other site 748727001689 active site 748727001690 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 748727001691 catalytic center binding site [active] 748727001692 ATP binding site [chemical binding]; other site 748727001693 MoxR-like ATPases [General function prediction only]; Region: COG0714 748727001694 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 748727001695 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748727001696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727001697 Coenzyme A binding pocket [chemical binding]; other site 748727001698 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 748727001699 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 748727001700 metal ion-dependent adhesion site (MIDAS); other site 748727001701 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 748727001702 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 748727001703 Active site serine [active] 748727001704 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 748727001705 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727001706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 748727001707 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727001708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727001709 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 748727001710 Walker A/P-loop; other site 748727001711 ATP binding site [chemical binding]; other site 748727001712 Q-loop/lid; other site 748727001713 ABC transporter signature motif; other site 748727001714 Walker B; other site 748727001715 D-loop; other site 748727001716 H-loop/switch region; other site 748727001717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727001718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001719 dimer interface [polypeptide binding]; other site 748727001720 phosphorylation site [posttranslational modification] 748727001721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001722 ATP binding site [chemical binding]; other site 748727001723 G-X-G motif; other site 748727001724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727001725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727001726 active site 748727001727 phosphorylation site [posttranslational modification] 748727001728 intermolecular recognition site; other site 748727001729 dimerization interface [polypeptide binding]; other site 748727001730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727001731 DNA binding site [nucleotide binding] 748727001732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727001733 EamA-like transporter family; Region: EamA; pfam00892 748727001734 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 748727001735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 748727001736 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748727001737 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 748727001738 putative acyl-acceptor binding pocket; other site 748727001739 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 748727001740 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 748727001741 active site 748727001742 catalytic residues [active] 748727001743 metal binding site [ion binding]; metal-binding site 748727001744 aconitate hydratase; Validated; Region: PRK07229 748727001745 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 748727001746 substrate binding site [chemical binding]; other site 748727001747 ligand binding site [chemical binding]; other site 748727001748 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 748727001749 substrate binding site [chemical binding]; other site 748727001750 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 748727001751 isocitrate dehydrogenase; Validated; Region: PRK06451 748727001752 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 748727001753 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 748727001754 homodimer interface [polypeptide binding]; other site 748727001755 substrate-cofactor binding pocket; other site 748727001756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727001757 catalytic residue [active] 748727001758 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 748727001759 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 748727001760 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 748727001761 substrate binding pocket [chemical binding]; other site 748727001762 dimer interface [polypeptide binding]; other site 748727001763 inhibitor binding site; inhibition site 748727001764 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748727001765 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 748727001766 B12 binding site [chemical binding]; other site 748727001767 cobalt ligand [ion binding]; other site 748727001768 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748727001769 phosphate binding site [ion binding]; other site 748727001770 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727001771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727001772 substrate binding pocket [chemical binding]; other site 748727001773 membrane-bound complex binding site; other site 748727001774 hinge residues; other site 748727001775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727001776 dimer interface [polypeptide binding]; other site 748727001777 conserved gate region; other site 748727001778 putative PBP binding loops; other site 748727001779 ABC-ATPase subunit interface; other site 748727001780 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748727001781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748727001782 Walker A/P-loop; other site 748727001783 ATP binding site [chemical binding]; other site 748727001784 Q-loop/lid; other site 748727001785 ABC transporter signature motif; other site 748727001786 Walker B; other site 748727001787 D-loop; other site 748727001788 H-loop/switch region; other site 748727001789 argininosuccinate synthase; Provisional; Region: PRK13820 748727001790 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 748727001791 ANP binding site [chemical binding]; other site 748727001792 Substrate Binding Site II [chemical binding]; other site 748727001793 Substrate Binding Site I [chemical binding]; other site 748727001794 argininosuccinate lyase; Provisional; Region: PRK00855 748727001795 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 748727001796 active sites [active] 748727001797 tetramer interface [polypeptide binding]; other site 748727001798 Uncharacterized conserved protein [Function unknown]; Region: COG2155 748727001799 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 748727001800 AsnC family; Region: AsnC_trans_reg; pfam01037 748727001801 asparagine synthetase A; Reviewed; Region: PRK06462 748727001802 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 748727001803 motif 1; other site 748727001804 dimer interface [polypeptide binding]; other site 748727001805 active site 748727001806 motif 2; other site 748727001807 motif 3; other site 748727001808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748727001809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727001810 DNA-binding site [nucleotide binding]; DNA binding site 748727001811 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748727001812 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 748727001813 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 748727001814 XdhC Rossmann domain; Region: XdhC_C; pfam13478 748727001815 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727001816 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 748727001817 RNA polymerase factor sigma-70; Validated; Region: PRK06811 748727001818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727001819 Transcriptional regulators [Transcription]; Region: FadR; COG2186 748727001820 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 748727001821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727001822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727001823 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 748727001824 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 748727001825 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 748727001826 active site 748727001827 dimer interface [polypeptide binding]; other site 748727001828 effector binding site; other site 748727001829 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748727001830 TSCPD domain; Region: TSCPD; pfam12637 748727001831 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 748727001832 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 748727001833 trimer interface [polypeptide binding]; other site 748727001834 putative metal binding site [ion binding]; other site 748727001835 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727001836 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748727001837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727001838 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 748727001839 putative active site [active] 748727001840 Zn binding site [ion binding]; other site 748727001841 Protein of unknown function (DUF327); Region: DUF327; pfam03885 748727001842 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748727001843 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748727001844 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727001845 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748727001846 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 748727001847 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748727001848 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 748727001849 S1 domain; Region: S1_2; pfam13509 748727001850 S1 domain; Region: S1_2; pfam13509 748727001851 Acyltransferase family; Region: Acyl_transf_3; pfam01757 748727001852 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 748727001853 NAD synthetase; Reviewed; Region: nadE; PRK02628 748727001854 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 748727001855 multimer interface [polypeptide binding]; other site 748727001856 active site 748727001857 catalytic triad [active] 748727001858 protein interface 1 [polypeptide binding]; other site 748727001859 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 748727001860 homodimer interface [polypeptide binding]; other site 748727001861 NAD binding pocket [chemical binding]; other site 748727001862 ATP binding pocket [chemical binding]; other site 748727001863 Mg binding site [ion binding]; other site 748727001864 active-site loop [active] 748727001865 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 748727001866 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 748727001867 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 748727001868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727001869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727001870 active site 748727001871 phosphorylation site [posttranslational modification] 748727001872 intermolecular recognition site; other site 748727001873 dimerization interface [polypeptide binding]; other site 748727001874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727001875 DNA binding site [nucleotide binding] 748727001876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727001877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727001878 dimerization interface [polypeptide binding]; other site 748727001879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727001880 dimer interface [polypeptide binding]; other site 748727001881 phosphorylation site [posttranslational modification] 748727001882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727001883 ATP binding site [chemical binding]; other site 748727001884 Mg2+ binding site [ion binding]; other site 748727001885 G-X-G motif; other site 748727001886 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 748727001887 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 748727001888 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 748727001889 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 748727001890 [4Fe-4S] binding site [ion binding]; other site 748727001891 molybdopterin cofactor binding site; other site 748727001892 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 748727001893 molybdopterin cofactor binding site; other site 748727001894 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 748727001895 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748727001896 dimer interface [polypeptide binding]; other site 748727001897 putative functional site; other site 748727001898 putative MPT binding site; other site 748727001899 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 748727001900 Walker A motif; other site 748727001901 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 748727001902 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 748727001903 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 748727001904 putative dimer interface [polypeptide binding]; other site 748727001905 [2Fe-2S] cluster binding site [ion binding]; other site 748727001906 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748727001907 dimer interface [polypeptide binding]; other site 748727001908 [2Fe-2S] cluster binding site [ion binding]; other site 748727001909 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 748727001910 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 748727001911 SLBB domain; Region: SLBB; pfam10531 748727001912 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748727001913 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727001914 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727001915 catalytic loop [active] 748727001916 iron binding site [ion binding]; other site 748727001917 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727001918 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727001919 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 748727001920 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748727001921 4Fe-4S binding domain; Region: Fer4; pfam00037 748727001922 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727001923 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 748727001924 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727001925 4Fe-4S binding domain; Region: Fer4; cl02805 748727001926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 748727001927 putative active site [active] 748727001928 heme pocket [chemical binding]; other site 748727001929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727001930 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 748727001931 Walker A motif; other site 748727001932 ATP binding site [chemical binding]; other site 748727001933 Walker B motif; other site 748727001934 arginine finger; other site 748727001935 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727001936 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 748727001937 Hexamer/Pentamer interface [polypeptide binding]; other site 748727001938 central pore; other site 748727001939 Sensory domain found in PocR; Region: PocR; pfam10114 748727001940 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 748727001941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727001942 dimer interface [polypeptide binding]; other site 748727001943 putative CheW interface [polypeptide binding]; other site 748727001944 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727001945 hypothetical protein; Provisional; Region: PRK04435 748727001946 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748727001947 homoserine dehydrogenase; Provisional; Region: PRK06349 748727001948 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 748727001949 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 748727001950 homoserine kinase; Provisional; Region: PRK01212 748727001951 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748727001952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 748727001953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727001954 Maf-like protein; Reviewed; Region: PRK00078 748727001955 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 748727001956 active site 748727001957 dimer interface [polypeptide binding]; other site 748727001958 hypothetical protein; Reviewed; Region: PRK00024 748727001959 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 748727001960 helix-hairpin-helix signature motif; other site 748727001961 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 748727001962 MPN+ (JAMM) motif; other site 748727001963 Zinc-binding site [ion binding]; other site 748727001964 rod shape-determining protein MreB; Provisional; Region: PRK13927 748727001965 MreB and similar proteins; Region: MreB_like; cd10225 748727001966 nucleotide binding site [chemical binding]; other site 748727001967 Mg binding site [ion binding]; other site 748727001968 putative protofilament interaction site [polypeptide binding]; other site 748727001969 RodZ interaction site [polypeptide binding]; other site 748727001970 rod shape-determining protein MreC; Provisional; Region: PRK13922 748727001971 rod shape-determining protein MreC; Region: MreC; pfam04085 748727001972 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 748727001973 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727001974 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727001975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727001976 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727001977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727001978 septum formation inhibitor; Reviewed; Region: minC; PRK00513 748727001979 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 748727001980 septum site-determining protein MinD; Region: minD_bact; TIGR01968 748727001981 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 748727001982 Switch I; other site 748727001983 Switch II; other site 748727001984 Septum formation topological specificity factor MinE; Region: MinE; cl00538 748727001985 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 748727001986 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 748727001987 active site 748727001988 dimer interfaces [polypeptide binding]; other site 748727001989 catalytic residues [active] 748727001990 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 748727001991 Peptidase family M50; Region: Peptidase_M50; pfam02163 748727001992 active site 748727001993 putative substrate binding region [chemical binding]; other site 748727001994 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 748727001995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727001996 FeS/SAM binding site; other site 748727001997 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 748727001998 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 748727001999 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 748727002000 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 748727002001 homodimer interface [polypeptide binding]; other site 748727002002 oligonucleotide binding site [chemical binding]; other site 748727002003 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 748727002004 hypothetical protein; Provisional; Region: PRK14553 748727002005 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 748727002006 GTPase CgtA; Reviewed; Region: obgE; PRK12297 748727002007 GTP1/OBG; Region: GTP1_OBG; pfam01018 748727002008 Obg GTPase; Region: Obg; cd01898 748727002009 G1 box; other site 748727002010 GTP/Mg2+ binding site [chemical binding]; other site 748727002011 Switch I region; other site 748727002012 G2 box; other site 748727002013 G3 box; other site 748727002014 Switch II region; other site 748727002015 G4 box; other site 748727002016 G5 box; other site 748727002017 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 748727002018 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 748727002019 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 748727002020 active site 748727002021 (T/H)XGH motif; other site 748727002022 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727002023 Zn2+ binding site [ion binding]; other site 748727002024 Mg2+ binding site [ion binding]; other site 748727002025 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 748727002026 homotrimer interaction site [polypeptide binding]; other site 748727002027 putative active site [active] 748727002028 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748727002029 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748727002030 active site 748727002031 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748727002032 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748727002033 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748727002034 SLBB domain; Region: SLBB; pfam10531 748727002035 Helix-hairpin-helix motif; Region: HHH; pfam00633 748727002036 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 748727002037 dimerization interface [polypeptide binding]; other site 748727002038 putative ATP binding site [chemical binding]; other site 748727002039 selenocysteine synthase; Provisional; Region: PRK04311 748727002040 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 748727002041 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 748727002042 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 748727002043 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 748727002044 G1 box; other site 748727002045 putative GEF interaction site [polypeptide binding]; other site 748727002046 GTP/Mg2+ binding site [chemical binding]; other site 748727002047 Switch I region; other site 748727002048 G2 box; other site 748727002049 G3 box; other site 748727002050 Switch II region; other site 748727002051 G4 box; other site 748727002052 G5 box; other site 748727002053 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 748727002054 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 748727002055 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 748727002056 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 748727002057 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 748727002058 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 748727002059 substrate binding pocket [chemical binding]; other site 748727002060 dimer interface [polypeptide binding]; other site 748727002061 inhibitor binding site; inhibition site 748727002062 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727002063 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748727002064 B12 binding site [chemical binding]; other site 748727002065 cobalt ligand [ion binding]; other site 748727002066 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 748727002067 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 748727002068 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727002069 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 748727002070 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 748727002071 substrate binding pocket [chemical binding]; other site 748727002072 dimer interface [polypeptide binding]; other site 748727002073 inhibitor binding site; inhibition site 748727002074 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727002075 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748727002076 B12 binding site [chemical binding]; other site 748727002077 cobalt ligand [ion binding]; other site 748727002078 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 748727002079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727002080 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 748727002081 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748727002082 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727002083 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 748727002084 Protein export membrane protein; Region: SecD_SecF; cl14618 748727002085 OsmC-like protein; Region: OsmC; pfam02566 748727002086 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748727002087 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748727002088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748727002089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748727002090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727002091 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727002092 Walker A/P-loop; other site 748727002093 ATP binding site [chemical binding]; other site 748727002094 Q-loop/lid; other site 748727002095 ABC transporter signature motif; other site 748727002096 Walker B; other site 748727002097 D-loop; other site 748727002098 H-loop/switch region; other site 748727002099 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727002100 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727002101 FtsX-like permease family; Region: FtsX; pfam02687 748727002102 FtsX-like permease family; Region: FtsX; pfam02687 748727002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727002105 active site 748727002106 phosphorylation site [posttranslational modification] 748727002107 intermolecular recognition site; other site 748727002108 dimerization interface [polypeptide binding]; other site 748727002109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727002110 DNA binding site [nucleotide binding] 748727002111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727002112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727002113 dimer interface [polypeptide binding]; other site 748727002114 phosphorylation site [posttranslational modification] 748727002115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002116 ATP binding site [chemical binding]; other site 748727002117 Mg2+ binding site [ion binding]; other site 748727002118 G-X-G motif; other site 748727002119 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748727002120 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748727002121 ligand binding site [chemical binding]; other site 748727002122 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 748727002123 putative switch regulator; other site 748727002124 non-specific DNA interactions [nucleotide binding]; other site 748727002125 DNA binding site [nucleotide binding] 748727002126 sequence specific DNA binding site [nucleotide binding]; other site 748727002127 putative cAMP binding site [chemical binding]; other site 748727002128 hybrid cluster protein; Provisional; Region: PRK05290 748727002129 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727002130 CODH interaction site; other site 748727002131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727002132 ACS interaction site; other site 748727002133 CODH interaction site; other site 748727002134 metal cluster binding site [ion binding]; other site 748727002135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727002136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002137 active site 748727002138 phosphorylation site [posttranslational modification] 748727002139 intermolecular recognition site; other site 748727002140 dimerization interface [polypeptide binding]; other site 748727002141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727002142 DNA binding site [nucleotide binding] 748727002143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727002144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727002145 Walker A/P-loop; other site 748727002146 ATP binding site [chemical binding]; other site 748727002147 Q-loop/lid; other site 748727002148 ABC transporter signature motif; other site 748727002149 Walker B; other site 748727002150 D-loop; other site 748727002151 H-loop/switch region; other site 748727002152 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 748727002153 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727002154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727002155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727002156 Walker A/P-loop; other site 748727002157 ATP binding site [chemical binding]; other site 748727002158 Q-loop/lid; other site 748727002159 ABC transporter signature motif; other site 748727002160 Walker B; other site 748727002161 D-loop; other site 748727002162 H-loop/switch region; other site 748727002163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727002164 FtsX-like permease family; Region: FtsX; pfam02687 748727002165 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727002166 FtsX-like permease family; Region: FtsX; pfam02687 748727002167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727002168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727002169 dimer interface [polypeptide binding]; other site 748727002170 phosphorylation site [posttranslational modification] 748727002171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002172 ATP binding site [chemical binding]; other site 748727002173 Mg2+ binding site [ion binding]; other site 748727002174 G-X-G motif; other site 748727002175 hypothetical protein; Provisional; Region: PRK14013 748727002176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727002177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002178 active site 748727002179 phosphorylation site [posttranslational modification] 748727002180 intermolecular recognition site; other site 748727002181 dimerization interface [polypeptide binding]; other site 748727002182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727002183 DNA binding site [nucleotide binding] 748727002184 hypothetical protein; Provisional; Region: PRK06771 748727002185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727002186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727002187 dimerization interface [polypeptide binding]; other site 748727002188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727002189 dimer interface [polypeptide binding]; other site 748727002190 phosphorylation site [posttranslational modification] 748727002191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002192 ATP binding site [chemical binding]; other site 748727002193 Mg2+ binding site [ion binding]; other site 748727002194 G-X-G motif; other site 748727002195 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 748727002196 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 748727002197 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748727002198 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 748727002199 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748727002200 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727002201 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748727002202 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 748727002203 Competence protein; Region: Competence; pfam03772 748727002204 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 748727002205 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 748727002206 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 748727002207 germination protease; Provisional; Region: PRK12362 748727002208 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 748727002209 stage II sporulation protein P; Region: spore_II_P; TIGR02867 748727002210 GTP-binding protein LepA; Provisional; Region: PRK05433 748727002211 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 748727002212 G1 box; other site 748727002213 putative GEF interaction site [polypeptide binding]; other site 748727002214 GTP/Mg2+ binding site [chemical binding]; other site 748727002215 Switch I region; other site 748727002216 G2 box; other site 748727002217 G3 box; other site 748727002218 Switch II region; other site 748727002219 G4 box; other site 748727002220 G5 box; other site 748727002221 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 748727002222 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 748727002223 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 748727002224 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 748727002225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727002226 FeS/SAM binding site; other site 748727002227 HemN C-terminal domain; Region: HemN_C; pfam06969 748727002228 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 748727002229 HTH domain; Region: HTH_11; cl17392 748727002230 GrpE; Region: GrpE; pfam01025 748727002231 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 748727002232 dimer interface [polypeptide binding]; other site 748727002233 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 748727002234 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 748727002235 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 748727002236 nucleotide binding site [chemical binding]; other site 748727002237 NEF interaction site [polypeptide binding]; other site 748727002238 SBD interface [polypeptide binding]; other site 748727002239 chaperone protein DnaJ; Provisional; Region: PRK14297 748727002240 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 748727002241 HSP70 interaction site [polypeptide binding]; other site 748727002242 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 748727002243 substrate binding site [polypeptide binding]; other site 748727002244 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 748727002245 Zn binding sites [ion binding]; other site 748727002246 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 748727002247 dimer interface [polypeptide binding]; other site 748727002248 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 748727002249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727002250 S-adenosylmethionine binding site [chemical binding]; other site 748727002251 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 748727002252 RNA methyltransferase, RsmE family; Region: TIGR00046 748727002253 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 748727002254 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748727002255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727002256 FeS/SAM binding site; other site 748727002257 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 748727002258 nucleotide binding site/active site [active] 748727002259 HIT family signature motif; other site 748727002260 catalytic residue [active] 748727002261 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 748727002262 Yqey-like protein; Region: YqeY; pfam09424 748727002263 YabP family; Region: YabP; cl06766 748727002264 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 748727002265 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 748727002266 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727002267 Zn2+ binding site [ion binding]; other site 748727002268 Mg2+ binding site [ion binding]; other site 748727002269 metal-binding heat shock protein; Provisional; Region: PRK00016 748727002270 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 748727002271 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 748727002272 active site 748727002273 GTPase Era; Reviewed; Region: era; PRK00089 748727002274 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 748727002275 G1 box; other site 748727002276 GTP/Mg2+ binding site [chemical binding]; other site 748727002277 Switch I region; other site 748727002278 G2 box; other site 748727002279 Switch II region; other site 748727002280 G3 box; other site 748727002281 G4 box; other site 748727002282 G5 box; other site 748727002283 KH domain; Region: KH_2; pfam07650 748727002284 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 748727002285 Recombination protein O N terminal; Region: RecO_N; pfam11967 748727002286 Recombination protein O C terminal; Region: RecO_C; pfam02565 748727002287 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 748727002288 HTH domain; Region: HTH_11; pfam08279 748727002289 FOG: CBS domain [General function prediction only]; Region: COG0517 748727002290 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 748727002291 pyruvate phosphate dikinase; Provisional; Region: PRK09279 748727002292 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 748727002293 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748727002294 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 748727002295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727002296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727002297 WHG domain; Region: WHG; pfam13305 748727002298 drug efflux system protein MdtG; Provisional; Region: PRK09874 748727002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727002300 putative substrate translocation pore; other site 748727002301 Isochorismatase family; Region: Isochorismatase; pfam00857 748727002302 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 748727002303 catalytic triad [active] 748727002304 conserved cis-peptide bond; other site 748727002305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727002306 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 748727002307 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 748727002308 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 748727002309 DNA primase; Validated; Region: dnaG; PRK05667 748727002310 CHC2 zinc finger; Region: zf-CHC2; pfam01807 748727002311 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 748727002312 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 748727002313 active site 748727002314 metal binding site [ion binding]; metal-binding site 748727002315 interdomain interaction site; other site 748727002316 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 748727002317 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 748727002318 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 748727002319 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 748727002320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727002321 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748727002322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727002323 DNA binding residues [nucleotide binding] 748727002324 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 748727002325 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 748727002326 Family of unknown function (DUF633); Region: DUF633; pfam04816 748727002327 Uncharacterized conserved protein [Function unknown]; Region: COG0327 748727002328 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 748727002329 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 748727002330 Putative zinc ribbon domain; Region: DUF164; pfam02591 748727002331 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 748727002332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727002333 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748727002334 hypothetical protein; Provisional; Region: PRK10621 748727002335 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 748727002336 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 748727002337 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748727002338 potential frameshift: common BLAST hit: gi|73668734|ref|YP_304749.1| beta-lactamase class C and other pencillin-binding proteins 748727002339 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 748727002340 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 748727002341 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748727002342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727002343 Walker A/P-loop; other site 748727002344 ATP binding site [chemical binding]; other site 748727002345 Q-loop/lid; other site 748727002346 ABC transporter signature motif; other site 748727002347 Walker B; other site 748727002348 D-loop; other site 748727002349 H-loop/switch region; other site 748727002350 ABC transporter; Region: ABC_tran_2; pfam12848 748727002351 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727002352 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 748727002353 active site 748727002354 catalytic triad [active] 748727002355 oxyanion hole [active] 748727002356 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 748727002357 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 748727002358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 748727002359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748727002360 protein binding site [polypeptide binding]; other site 748727002361 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727002362 MarR family; Region: MarR_2; pfam12802 748727002363 MarR family; Region: MarR_2; cl17246 748727002364 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727002365 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727002366 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 748727002367 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748727002368 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 748727002369 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748727002370 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727002371 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727002372 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727002373 Spore germination protein; Region: Spore_permease; cl17796 748727002374 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 748727002375 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 748727002376 active site 748727002377 catalytic triad [active] 748727002378 oxyanion hole [active] 748727002379 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 748727002380 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 748727002381 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 748727002382 ATP binding site [chemical binding]; other site 748727002383 active site 748727002384 substrate binding site [chemical binding]; other site 748727002385 amidophosphoribosyltransferase; Provisional; Region: PRK05793 748727002386 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 748727002387 active site 748727002388 tetramer interface [polypeptide binding]; other site 748727002389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727002390 active site 748727002391 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 748727002392 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 748727002393 dimerization interface [polypeptide binding]; other site 748727002394 putative ATP binding site [chemical binding]; other site 748727002395 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 748727002396 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 748727002397 active site 748727002398 substrate binding site [chemical binding]; other site 748727002399 cosubstrate binding site; other site 748727002400 catalytic site [active] 748727002401 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 748727002402 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 748727002403 purine monophosphate binding site [chemical binding]; other site 748727002404 dimer interface [polypeptide binding]; other site 748727002405 putative catalytic residues [active] 748727002406 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 748727002407 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 748727002408 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 748727002409 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 748727002410 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 748727002411 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 748727002412 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 748727002413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727002414 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 748727002415 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002416 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002417 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002418 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 748727002419 hypothetical protein; Validated; Region: PRK07121 748727002420 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 748727002421 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748727002422 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727002423 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727002424 catalytic loop [active] 748727002425 iron binding site [ion binding]; other site 748727002426 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 748727002427 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727002428 4Fe-4S binding domain; Region: Fer4; pfam00037 748727002429 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 748727002430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727002431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727002432 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727002433 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 748727002434 DNA binding residues [nucleotide binding] 748727002435 drug binding residues [chemical binding]; other site 748727002436 dimer interface [polypeptide binding]; other site 748727002437 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 748727002438 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 748727002439 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 748727002440 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 748727002441 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727002442 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 748727002443 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 748727002444 homodimer interface [polypeptide binding]; other site 748727002445 substrate-cofactor binding pocket; other site 748727002446 catalytic residue [active] 748727002447 TRAM domain; Region: TRAM; pfam01938 748727002448 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 748727002449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727002450 S-adenosylmethionine binding site [chemical binding]; other site 748727002451 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 748727002452 Sulfatase; Region: Sulfatase; pfam00884 748727002453 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 748727002454 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 748727002455 active site 748727002456 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 748727002457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727002458 dimer interface [polypeptide binding]; other site 748727002459 conserved gate region; other site 748727002460 putative PBP binding loops; other site 748727002461 ABC-ATPase subunit interface; other site 748727002462 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 748727002463 NMT1/THI5 like; Region: NMT1; pfam09084 748727002464 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 748727002465 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 748727002466 Walker A/P-loop; other site 748727002467 ATP binding site [chemical binding]; other site 748727002468 Q-loop/lid; other site 748727002469 ABC transporter signature motif; other site 748727002470 Walker B; other site 748727002471 D-loop; other site 748727002472 H-loop/switch region; other site 748727002473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727002474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002475 active site 748727002476 phosphorylation site [posttranslational modification] 748727002477 intermolecular recognition site; other site 748727002478 dimerization interface [polypeptide binding]; other site 748727002479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727002480 DNA binding site [nucleotide binding] 748727002481 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 748727002482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748727002483 Beta-lactamase; Region: Beta-lactamase; pfam00144 748727002484 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 748727002485 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727002486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727002487 DNA-binding site [nucleotide binding]; DNA binding site 748727002488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727002489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727002490 homodimer interface [polypeptide binding]; other site 748727002491 catalytic residue [active] 748727002492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727002494 putative substrate translocation pore; other site 748727002495 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 748727002496 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 748727002497 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 748727002498 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 748727002499 putative active site [active] 748727002500 catalytic site [active] 748727002501 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 748727002502 putative active site [active] 748727002503 catalytic site [active] 748727002504 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 748727002505 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727002506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727002507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727002508 Walker A/P-loop; other site 748727002509 ATP binding site [chemical binding]; other site 748727002510 Q-loop/lid; other site 748727002511 ABC transporter signature motif; other site 748727002512 Walker B; other site 748727002513 D-loop; other site 748727002514 H-loop/switch region; other site 748727002515 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727002516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727002517 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748727002518 Walker A/P-loop; other site 748727002519 ATP binding site [chemical binding]; other site 748727002520 Q-loop/lid; other site 748727002521 ABC transporter signature motif; other site 748727002522 Walker B; other site 748727002523 D-loop; other site 748727002524 H-loop/switch region; other site 748727002525 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 748727002526 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 748727002527 [4Fe-4S] binding site [ion binding]; other site 748727002528 molybdopterin cofactor binding site; other site 748727002529 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 748727002530 molybdopterin cofactor binding site; other site 748727002531 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 748727002532 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 748727002533 ligand binding site [chemical binding]; other site 748727002534 calcium binding site [ion binding]; other site 748727002535 CHASE3 domain; Region: CHASE3; pfam05227 748727002536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727002537 dimerization interface [polypeptide binding]; other site 748727002538 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727002539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727002540 dimer interface [polypeptide binding]; other site 748727002541 putative CheW interface [polypeptide binding]; other site 748727002542 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 748727002543 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748727002544 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748727002545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727002546 Coenzyme A binding pocket [chemical binding]; other site 748727002547 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727002548 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 748727002549 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 748727002550 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 748727002551 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 748727002552 Predicted secreted protein [Function unknown]; Region: COG4086 748727002553 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 748727002554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 748727002555 Cache domain; Region: Cache_1; pfam02743 748727002556 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727002557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727002558 dimer interface [polypeptide binding]; other site 748727002559 putative CheW interface [polypeptide binding]; other site 748727002560 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727002561 2-isopropylmalate synthase; Validated; Region: PRK00915 748727002562 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 748727002563 active site 748727002564 catalytic residues [active] 748727002565 metal binding site [ion binding]; metal-binding site 748727002566 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 748727002567 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 748727002568 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 748727002569 substrate binding site [chemical binding]; other site 748727002570 ligand binding site [chemical binding]; other site 748727002571 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 748727002572 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 748727002573 substrate binding site [chemical binding]; other site 748727002574 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 748727002575 tartrate dehydrogenase; Region: TTC; TIGR02089 748727002576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727002577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727002578 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 748727002579 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748727002580 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 748727002581 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727002582 ACS interaction site; other site 748727002583 CODH interaction site; other site 748727002584 metal cluster binding site [ion binding]; other site 748727002585 helicase 45; Provisional; Region: PTZ00424 748727002586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748727002587 ATP binding site [chemical binding]; other site 748727002588 putative Mg++ binding site [ion binding]; other site 748727002589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727002590 nucleotide binding region [chemical binding]; other site 748727002591 ATP-binding site [chemical binding]; other site 748727002592 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 748727002593 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 748727002594 oligomer interface [polypeptide binding]; other site 748727002595 metal binding site [ion binding]; metal-binding site 748727002596 metal binding site [ion binding]; metal-binding site 748727002597 putative Cl binding site [ion binding]; other site 748727002598 aspartate ring; other site 748727002599 basic sphincter; other site 748727002600 hydrophobic gate; other site 748727002601 periplasmic entrance; other site 748727002602 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727002603 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 748727002604 Walker A/P-loop; other site 748727002605 ATP binding site [chemical binding]; other site 748727002606 Q-loop/lid; other site 748727002607 ABC transporter signature motif; other site 748727002608 Walker B; other site 748727002609 D-loop; other site 748727002610 H-loop/switch region; other site 748727002611 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 748727002612 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727002613 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 748727002614 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727002615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727002616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002617 active site 748727002618 phosphorylation site [posttranslational modification] 748727002619 intermolecular recognition site; other site 748727002620 dimerization interface [polypeptide binding]; other site 748727002621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727002622 DNA binding site [nucleotide binding] 748727002623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727002624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 748727002625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727002626 dimer interface [polypeptide binding]; other site 748727002627 phosphorylation site [posttranslational modification] 748727002628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002629 ATP binding site [chemical binding]; other site 748727002630 Mg2+ binding site [ion binding]; other site 748727002631 G-X-G motif; other site 748727002632 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 748727002633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002634 ATP binding site [chemical binding]; other site 748727002635 Mg2+ binding site [ion binding]; other site 748727002636 G-X-G motif; other site 748727002637 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748727002638 anchoring element; other site 748727002639 dimer interface [polypeptide binding]; other site 748727002640 ATP binding site [chemical binding]; other site 748727002641 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 748727002642 active site 748727002643 metal binding site [ion binding]; metal-binding site 748727002644 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748727002645 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 748727002646 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748727002647 CAP-like domain; other site 748727002648 active site 748727002649 primary dimer interface [polypeptide binding]; other site 748727002650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748727002651 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 748727002652 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 748727002653 DJ-1 family protein; Region: not_thiJ; TIGR01383 748727002654 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 748727002655 conserved cys residue [active] 748727002656 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 748727002657 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 748727002658 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748727002659 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 748727002660 DHH family; Region: DHH; pfam01368 748727002661 DHHA1 domain; Region: DHHA1; pfam02272 748727002662 arginine repressor; Provisional; Region: argR; PRK00441 748727002663 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 748727002664 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 748727002665 amino acid transporter; Region: 2A0306; TIGR00909 748727002666 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727002667 arginine deiminase; Provisional; Region: PRK01388 748727002668 ornithine carbamoyltransferase; Provisional; Region: PRK04284 748727002669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727002670 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727002671 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 748727002672 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 748727002673 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727002674 putative substrate binding site [chemical binding]; other site 748727002675 nucleotide binding site [chemical binding]; other site 748727002676 nucleotide binding site [chemical binding]; other site 748727002677 homodimer interface [polypeptide binding]; other site 748727002678 Cache domain; Region: Cache_1; pfam02743 748727002679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727002680 dimerization interface [polypeptide binding]; other site 748727002681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727002682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727002683 dimer interface [polypeptide binding]; other site 748727002684 putative CheW interface [polypeptide binding]; other site 748727002685 Predicted transcriptional regulators [Transcription]; Region: COG1378 748727002686 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 748727002687 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 748727002688 C-terminal domain interface [polypeptide binding]; other site 748727002689 sugar binding site [chemical binding]; other site 748727002690 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 748727002691 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 748727002692 active site 748727002693 homodimer interface [polypeptide binding]; other site 748727002694 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 748727002695 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 748727002696 dimer interface [polypeptide binding]; other site 748727002697 PYR/PP interface [polypeptide binding]; other site 748727002698 TPP binding site [chemical binding]; other site 748727002699 substrate binding site [chemical binding]; other site 748727002700 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 748727002701 Domain of unknown function; Region: EKR; pfam10371 748727002702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727002703 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 748727002704 TPP-binding site [chemical binding]; other site 748727002705 dimer interface [polypeptide binding]; other site 748727002706 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 748727002707 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 748727002708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727002709 motif II; other site 748727002710 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 748727002711 homodimer interface [polypeptide binding]; other site 748727002712 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 748727002713 substrate-cofactor binding pocket; other site 748727002714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727002715 catalytic residue [active] 748727002716 Uncharacterized conserved protein [Function unknown]; Region: COG1315 748727002717 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 748727002718 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 748727002719 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 748727002720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002721 active site 748727002722 phosphorylation site [posttranslational modification] 748727002723 intermolecular recognition site; other site 748727002724 dimerization interface [polypeptide binding]; other site 748727002725 CheB methylesterase; Region: CheB_methylest; pfam01339 748727002726 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 748727002727 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 748727002728 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 748727002729 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 748727002730 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 748727002731 putative binding surface; other site 748727002732 active site 748727002733 P2 response regulator binding domain; Region: P2; pfam07194 748727002734 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 748727002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727002736 ATP binding site [chemical binding]; other site 748727002737 Mg2+ binding site [ion binding]; other site 748727002738 G-X-G motif; other site 748727002739 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 748727002740 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 748727002741 CheC-like family; Region: CheC; pfam04509 748727002742 CheC-like family; Region: CheC; pfam04509 748727002743 Response regulator receiver domain; Region: Response_reg; pfam00072 748727002744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727002745 active site 748727002746 phosphorylation site [posttranslational modification] 748727002747 intermolecular recognition site; other site 748727002748 dimerization interface [polypeptide binding]; other site 748727002749 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 748727002750 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 748727002751 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 748727002752 flagellar motor switch protein; Validated; Region: PRK08119 748727002753 CheC-like family; Region: CheC; pfam04509 748727002754 CheC-like family; Region: CheC; pfam04509 748727002755 flagellar motor switch protein FliN; Region: fliN; TIGR02480 748727002756 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 748727002757 FlgN protein; Region: FlgN; pfam05130 748727002758 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 748727002759 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748727002760 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 748727002761 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748727002762 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748727002763 flagellar assembly protein FliW; Provisional; Region: PRK13285 748727002764 Global regulator protein family; Region: CsrA; pfam02599 748727002765 FlaG protein; Region: FlaG; pfam03646 748727002766 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 748727002767 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 748727002768 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 748727002769 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748727002770 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 748727002771 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 748727002772 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748727002773 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748727002774 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748727002775 active site 748727002776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727002777 binding surface 748727002778 TPR motif; other site 748727002779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 748727002780 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727002781 binding surface 748727002782 TPR motif; other site 748727002783 TPR repeat; Region: TPR_11; pfam13414 748727002784 Methyltransferase domain; Region: Methyltransf_23; pfam13489 748727002785 Methyltransferase domain; Region: Methyltransf_11; pfam08241 748727002786 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 748727002787 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 748727002788 Global regulator protein family; Region: CsrA; pfam02599 748727002789 hypothetical protein; Reviewed; Region: PRK12275 748727002790 four helix bundle protein; Region: TIGR02436 748727002791 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748727002792 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748727002793 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748727002794 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748727002795 active site 748727002796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 748727002797 binding surface 748727002798 TPR motif; other site 748727002799 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 748727002800 putative metal binding site; other site 748727002801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727002802 binding surface 748727002803 TPR motif; other site 748727002804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727002805 TPR motif; other site 748727002806 binding surface 748727002807 TPR repeat; Region: TPR_11; pfam13414 748727002808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727002809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727002810 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 748727002811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727002812 binding surface 748727002813 TPR motif; other site 748727002814 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 748727002815 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 748727002816 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 748727002817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727002818 active site 748727002819 DNA binding site [nucleotide binding] 748727002820 Int/Topo IB signature motif; other site 748727002821 potential frameshift: common BLAST hit: gi|167630973|ref|YP_001681472.1| phage integrase 748727002822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727002823 active site 748727002824 Int/Topo IB signature motif; other site 748727002825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727002826 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727002827 DNA binding site [nucleotide binding] 748727002828 active site 748727002829 Int/Topo IB signature motif; other site 748727002830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727002831 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 748727002832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 748727002833 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 748727002834 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 748727002835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 748727002836 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 748727002837 potential frameshift: common BLAST hit: gi|134298178|ref|YP_001111674.1| transposase 748727002838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748727002839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748727002840 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 748727002841 Initiator Replication protein; Region: Rep_3; cl17676 748727002842 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 748727002843 active site 748727002844 NTP binding site [chemical binding]; other site 748727002845 metal binding triad [ion binding]; metal-binding site 748727002846 antibiotic binding site [chemical binding]; other site 748727002847 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 748727002848 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748727002849 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 748727002850 putative metal binding site; other site 748727002851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727002852 binding surface 748727002853 TPR motif; other site 748727002854 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 748727002855 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 748727002856 metal binding triad [ion binding]; metal-binding site 748727002857 Protein of unknown function DUF86; Region: DUF86; pfam01934 748727002858 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 748727002859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727002860 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 748727002861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748727002862 NAD(P) binding site [chemical binding]; other site 748727002863 active site 748727002864 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 748727002865 Predicted membrane protein [Function unknown]; Region: COG4640 748727002866 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 748727002867 Putative motility protein; Region: YjfB_motility; pfam14070 748727002868 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002869 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002870 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727002871 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727002872 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727002873 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727002874 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727002875 homoserine dehydrogenase; Provisional; Region: PRK06349 748727002876 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 748727002877 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 748727002878 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 748727002879 Protein of unknown function (DUF441); Region: DUF441; pfam04284 748727002880 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 748727002881 YopX protein; Region: YopX; cl09859 748727002882 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 748727002883 trimer interface [polypeptide binding]; other site 748727002884 active site 748727002885 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 748727002886 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748727002887 dimer interface [polypeptide binding]; other site 748727002888 ssDNA binding site [nucleotide binding]; other site 748727002889 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748727002890 Cache domain; Region: Cache_1; pfam02743 748727002891 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727002892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727002893 dimer interface [polypeptide binding]; other site 748727002894 putative CheW interface [polypeptide binding]; other site 748727002895 flagellin; Provisional; Region: PRK12804 748727002896 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748727002897 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748727002898 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 748727002899 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 748727002900 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748727002901 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748727002902 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 748727002903 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 748727002904 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 748727002905 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 748727002906 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 748727002907 FliG C-terminal domain; Region: FliG_C; pfam01706 748727002908 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 748727002909 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 748727002910 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748727002911 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 748727002912 Walker A motif/ATP binding site; other site 748727002913 Walker B motif; other site 748727002914 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 748727002915 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 748727002916 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 748727002917 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 748727002918 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 748727002919 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 748727002920 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748727002921 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748727002922 Flagellar protein (FlbD); Region: FlbD; pfam06289 748727002923 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 748727002924 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 748727002925 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 748727002926 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 748727002927 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 748727002928 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 748727002929 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 748727002930 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 748727002931 FHIPEP family; Region: FHIPEP; pfam00771 748727002932 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 748727002933 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727002934 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 748727002935 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 748727002936 P-loop; other site 748727002937 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 748727002938 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 748727002939 Flagellar protein YcgR; Region: YcgR_2; pfam12945 748727002940 PilZ domain; Region: PilZ; pfam07238 748727002941 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 748727002942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727002943 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748727002944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727002945 DNA binding residues [nucleotide binding] 748727002946 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 748727002947 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748727002948 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 748727002949 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 748727002950 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748727002951 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748727002952 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 748727002953 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748727002954 DRTGG domain; Region: DRTGG; pfam07085 748727002955 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748727002956 DHHA2 domain; Region: DHHA2; pfam02833 748727002957 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748727002958 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748727002959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727002960 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748727002961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727002962 motif II; other site 748727002963 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748727002964 AAA domain; Region: AAA_32; pfam13654 748727002965 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 748727002966 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748727002967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727002968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727002969 GTP-binding protein YchF; Reviewed; Region: PRK09601 748727002970 YchF GTPase; Region: YchF; cd01900 748727002971 G1 box; other site 748727002972 GTP/Mg2+ binding site [chemical binding]; other site 748727002973 Switch I region; other site 748727002974 G2 box; other site 748727002975 Switch II region; other site 748727002976 G3 box; other site 748727002977 G4 box; other site 748727002978 G5 box; other site 748727002979 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 748727002980 cell division protein MraZ; Reviewed; Region: PRK00326 748727002981 MraZ protein; Region: MraZ; pfam02381 748727002982 MraZ protein; Region: MraZ; pfam02381 748727002983 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 748727002984 MraW methylase family; Region: Methyltransf_5; cl17771 748727002985 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 748727002986 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727002987 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748727002988 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 748727002989 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748727002990 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727002991 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748727002992 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 748727002993 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748727002994 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727002995 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748727002996 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 748727002997 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 748727002998 Mg++ binding site [ion binding]; other site 748727002999 putative catalytic motif [active] 748727003000 putative substrate binding site [chemical binding]; other site 748727003001 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 748727003002 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 748727003003 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 748727003004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 748727003005 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 748727003006 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 748727003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 748727003008 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 748727003009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 748727003010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748727003011 catalytic residue [active] 748727003012 Protein of unknown function (DUF552); Region: DUF552; cl00775 748727003013 YGGT family; Region: YGGT; pfam02325 748727003014 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 748727003015 DivIVA protein; Region: DivIVA; pfam05103 748727003016 DivIVA domain; Region: DivI1A_domain; TIGR03544 748727003017 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 748727003018 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 748727003019 lipoprotein signal peptidase; Provisional; Region: PRK14791 748727003020 lipoprotein signal peptidase; Provisional; Region: PRK14787 748727003021 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748727003022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727003023 RNA binding surface [nucleotide binding]; other site 748727003024 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748727003025 active site 748727003026 uracil transporter; Provisional; Region: PRK10720 748727003027 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 748727003028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727003029 active site 748727003030 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 748727003031 Domain of unknown function (DUF814); Region: DUF814; pfam05670 748727003032 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 748727003033 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748727003034 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748727003035 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 748727003036 dimer interface [polypeptide binding]; other site 748727003037 FMN binding site [chemical binding]; other site 748727003038 VanZ like family; Region: VanZ; cl01971 748727003039 Phospholipid methyltransferase; Region: PEMT; pfam04191 748727003040 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748727003041 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 748727003042 ligand binding site [chemical binding]; other site 748727003043 flexible hinge region; other site 748727003044 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748727003045 putative switch regulator; other site 748727003046 non-specific DNA interactions [nucleotide binding]; other site 748727003047 DNA binding site [nucleotide binding] 748727003048 sequence specific DNA binding site [nucleotide binding]; other site 748727003049 putative cAMP binding site [chemical binding]; other site 748727003050 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727003051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727003052 S-adenosylmethionine binding site [chemical binding]; other site 748727003053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727003054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727003055 Coenzyme A binding pocket [chemical binding]; other site 748727003056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 748727003057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727003058 ATP binding site [chemical binding]; other site 748727003059 Mg2+ binding site [ion binding]; other site 748727003060 G-X-G motif; other site 748727003061 Domain of unknown function (DUF955); Region: DUF955; cl01076 748727003062 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 748727003063 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 748727003064 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 748727003065 Walker A motif; other site 748727003066 ATP binding site [chemical binding]; other site 748727003067 Walker B motif; other site 748727003068 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 748727003069 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748727003070 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748727003071 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 748727003072 Acylphosphatase; Region: Acylphosphatase; cl00551 748727003073 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748727003074 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748727003075 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748727003076 active site 748727003077 elongation factor P; Validated; Region: PRK00529 748727003078 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 748727003079 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 748727003080 RNA binding site [nucleotide binding]; other site 748727003081 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 748727003082 RNA binding site [nucleotide binding]; other site 748727003083 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 748727003084 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 748727003085 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 748727003086 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 748727003087 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 748727003088 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 748727003089 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 748727003090 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 748727003091 Asp23 family; Region: Asp23; pfam03780 748727003092 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 748727003093 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 748727003094 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 748727003095 generic binding surface II; other site 748727003096 generic binding surface I; other site 748727003097 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 748727003098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748727003099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748727003100 substrate binding pocket [chemical binding]; other site 748727003101 chain length determination region; other site 748727003102 substrate-Mg2+ binding site; other site 748727003103 catalytic residues [active] 748727003104 aspartate-rich region 1; other site 748727003105 active site lid residues [active] 748727003106 aspartate-rich region 2; other site 748727003107 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 748727003108 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 748727003109 TPP-binding site; other site 748727003110 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748727003111 PYR/PP interface [polypeptide binding]; other site 748727003112 dimer interface [polypeptide binding]; other site 748727003113 TPP binding site [chemical binding]; other site 748727003114 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748727003115 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 748727003116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727003117 RNA binding surface [nucleotide binding]; other site 748727003118 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 748727003119 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 748727003120 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 748727003121 arginine repressor; Provisional; Region: argR; PRK00441 748727003122 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 748727003123 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 748727003124 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 748727003125 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748727003126 Walker A/P-loop; other site 748727003127 ATP binding site [chemical binding]; other site 748727003128 Q-loop/lid; other site 748727003129 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748727003130 ABC transporter signature motif; other site 748727003131 Walker B; other site 748727003132 D-loop; other site 748727003133 H-loop/switch region; other site 748727003134 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 748727003135 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 748727003136 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 748727003137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727003138 active site 748727003139 phosphorylation site [posttranslational modification] 748727003140 intermolecular recognition site; other site 748727003141 dimerization interface [polypeptide binding]; other site 748727003142 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 748727003143 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 748727003144 dimer interface [polypeptide binding]; other site 748727003145 ADP-ribose binding site [chemical binding]; other site 748727003146 active site 748727003147 nudix motif; other site 748727003148 metal binding site [ion binding]; metal-binding site 748727003149 Integral membrane protein DUF95; Region: DUF95; cl00572 748727003150 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 748727003151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727003152 active site 748727003153 DNA binding site [nucleotide binding] 748727003154 Int/Topo IB signature motif; other site 748727003155 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748727003156 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748727003157 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748727003158 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 748727003159 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 748727003160 active site 748727003161 NTP binding site [chemical binding]; other site 748727003162 metal binding triad [ion binding]; metal-binding site 748727003163 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 748727003164 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 748727003165 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 748727003166 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 748727003167 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748727003168 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748727003169 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748727003170 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 748727003171 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 748727003172 SLBB domain; Region: SLBB; pfam10531 748727003173 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727003174 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 748727003175 FMN-binding domain; Region: FMN_bind; cl01081 748727003176 electron transport complex RsxE subunit; Provisional; Region: PRK12405 748727003177 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 748727003178 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 748727003179 Putative Fe-S cluster; Region: FeS; cl17515 748727003180 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727003181 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727003182 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 748727003183 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 748727003184 trimer interface [polypeptide binding]; other site 748727003185 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 748727003186 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 748727003187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727003188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748727003189 active site 748727003190 motif I; other site 748727003191 motif II; other site 748727003192 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748727003193 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 748727003194 putative homodimer interface [polypeptide binding]; other site 748727003195 putative homotetramer interface [polypeptide binding]; other site 748727003196 putative allosteric switch controlling residues; other site 748727003197 putative metal binding site [ion binding]; other site 748727003198 putative homodimer-homodimer interface [polypeptide binding]; other site 748727003199 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 748727003200 Uncharacterized conserved protein [Function unknown]; Region: COG2966 748727003201 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 748727003202 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 748727003203 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 748727003204 dimer interface [polypeptide binding]; other site 748727003205 active site 748727003206 glycine-pyridoxal phosphate binding site [chemical binding]; other site 748727003207 folate binding site [chemical binding]; other site 748727003208 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727003209 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727003210 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727003211 DNA binding residues [nucleotide binding] 748727003212 putative dimer interface [polypeptide binding]; other site 748727003213 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 748727003214 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 748727003215 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 748727003216 dimerization interface [polypeptide binding]; other site 748727003217 ATP binding site [chemical binding]; other site 748727003218 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 748727003219 dimerization interface [polypeptide binding]; other site 748727003220 ATP binding site [chemical binding]; other site 748727003221 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 748727003222 putative active site [active] 748727003223 catalytic triad [active] 748727003224 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748727003225 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748727003226 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748727003227 putative active site [active] 748727003228 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 748727003229 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727003230 putative NAD(P) binding site [chemical binding]; other site 748727003231 catalytic Zn binding site [ion binding]; other site 748727003232 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727003233 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 748727003234 nucleotide binding site [chemical binding]; other site 748727003235 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 748727003236 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 748727003237 putative ligand binding site [chemical binding]; other site 748727003238 putative NAD binding site [chemical binding]; other site 748727003239 catalytic site [active] 748727003240 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 748727003241 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 748727003242 fructuronate transporter; Provisional; Region: PRK10034; cl15264 748727003243 gluconate transporter; Region: gntP; TIGR00791 748727003244 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 748727003245 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 748727003246 N- and C-terminal domain interface [polypeptide binding]; other site 748727003247 active site 748727003248 catalytic site [active] 748727003249 metal binding site [ion binding]; metal-binding site 748727003250 carbohydrate binding site [chemical binding]; other site 748727003251 ATP binding site [chemical binding]; other site 748727003252 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 748727003253 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748727003254 putative ligand binding site [chemical binding]; other site 748727003255 putative NAD binding site [chemical binding]; other site 748727003256 catalytic site [active] 748727003257 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 748727003258 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 748727003259 active site 748727003260 intersubunit interface [polypeptide binding]; other site 748727003261 catalytic residue [active] 748727003262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727003263 dimerization interface [polypeptide binding]; other site 748727003264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727003265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727003266 dimer interface [polypeptide binding]; other site 748727003267 putative CheW interface [polypeptide binding]; other site 748727003268 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 748727003269 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 748727003270 EDD domain protein, DegV family; Region: DegV; TIGR00762 748727003271 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748727003272 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 748727003273 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 748727003274 dimer interface [polypeptide binding]; other site 748727003275 motif 1; other site 748727003276 active site 748727003277 motif 2; other site 748727003278 motif 3; other site 748727003279 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 748727003280 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 748727003281 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 748727003282 histidinol dehydrogenase; Region: hisD; TIGR00069 748727003283 NAD binding site [chemical binding]; other site 748727003284 dimerization interface [polypeptide binding]; other site 748727003285 product binding site; other site 748727003286 substrate binding site [chemical binding]; other site 748727003287 zinc binding site [ion binding]; other site 748727003288 catalytic residues [active] 748727003289 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 748727003290 putative active site pocket [active] 748727003291 4-fold oligomerization interface [polypeptide binding]; other site 748727003292 metal binding residues [ion binding]; metal-binding site 748727003293 3-fold/trimer interface [polypeptide binding]; other site 748727003294 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 748727003295 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 748727003296 putative active site [active] 748727003297 oxyanion strand; other site 748727003298 catalytic triad [active] 748727003299 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 748727003300 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 748727003301 catalytic residues [active] 748727003302 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 748727003303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727003304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727003305 homodimer interface [polypeptide binding]; other site 748727003306 catalytic residue [active] 748727003307 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 748727003308 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 748727003309 substrate binding site [chemical binding]; other site 748727003310 glutamase interaction surface [polypeptide binding]; other site 748727003311 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 748727003312 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 748727003313 metal binding site [ion binding]; metal-binding site 748727003314 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 748727003315 active site 748727003316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727003317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727003318 active site 748727003319 phosphorylation site [posttranslational modification] 748727003320 intermolecular recognition site; other site 748727003321 dimerization interface [polypeptide binding]; other site 748727003322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727003323 DNA binding site [nucleotide binding] 748727003324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727003325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727003326 dimerization interface [polypeptide binding]; other site 748727003327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727003328 dimer interface [polypeptide binding]; other site 748727003329 phosphorylation site [posttranslational modification] 748727003330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727003331 ATP binding site [chemical binding]; other site 748727003332 Mg2+ binding site [ion binding]; other site 748727003333 G-X-G motif; other site 748727003334 Predicted permeases [General function prediction only]; Region: COG0679 748727003335 histidinol-phosphatase; Provisional; Region: PRK05588 748727003336 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748727003337 active site 748727003338 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 748727003339 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 748727003340 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 748727003341 dimer interface [polypeptide binding]; other site 748727003342 active site 748727003343 glycine loop; other site 748727003344 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 748727003345 4Fe-4S binding domain; Region: Fer4; pfam00037 748727003346 4Fe-4S binding domain; Region: Fer4; cl02805 748727003347 Response regulator receiver domain; Region: Response_reg; pfam00072 748727003348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727003349 active site 748727003350 phosphorylation site [posttranslational modification] 748727003351 intermolecular recognition site; other site 748727003352 dimerization interface [polypeptide binding]; other site 748727003353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727003354 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727003355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727003356 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 748727003357 Sensory domain found in PocR; Region: PocR; pfam10114 748727003358 Histidine kinase; Region: His_kinase; pfam06580 748727003359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727003360 ATP binding site [chemical binding]; other site 748727003361 Mg2+ binding site [ion binding]; other site 748727003362 G-X-G motif; other site 748727003363 propanediol utilization protein PduB; Provisional; Region: PRK15415 748727003364 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 748727003365 putative hexamer interface [polypeptide binding]; other site 748727003366 putative hexagonal pore; other site 748727003367 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 748727003368 putative hexamer interface [polypeptide binding]; other site 748727003369 putative hexagonal pore; other site 748727003370 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727003371 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 748727003372 putative active site [active] 748727003373 metal binding site [ion binding]; metal-binding site 748727003374 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 748727003375 amphipathic channel; other site 748727003376 Asn-Pro-Ala signature motifs; other site 748727003377 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 748727003378 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 748727003379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727003380 nucleotide binding site [chemical binding]; other site 748727003381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727003382 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 748727003383 Hexamer interface [polypeptide binding]; other site 748727003384 Hexagonal pore residue; other site 748727003385 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 748727003386 Hexamer/Pentamer interface [polypeptide binding]; other site 748727003387 central pore; other site 748727003388 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 748727003389 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 748727003390 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727003391 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 748727003392 Hexamer interface [polypeptide binding]; other site 748727003393 Hexagonal pore residue; other site 748727003394 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 748727003395 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748727003396 putative catalytic cysteine [active] 748727003397 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 748727003398 Propanediol utilisation protein PduL; Region: PduL; pfam06130 748727003399 Propanediol utilisation protein PduL; Region: PduL; pfam06130 748727003400 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727003401 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 748727003402 Hexamer interface [polypeptide binding]; other site 748727003403 Putative hexagonal pore residue; other site 748727003404 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727003405 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 748727003406 Hexamer interface [polypeptide binding]; other site 748727003407 Putative hexagonal pore residue; other site 748727003408 recombination factor protein RarA; Reviewed; Region: PRK13342 748727003409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727003410 Walker A motif; other site 748727003411 ATP binding site [chemical binding]; other site 748727003412 Walker B motif; other site 748727003413 arginine finger; other site 748727003414 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 748727003415 alanine racemase; Reviewed; Region: alr; PRK00053 748727003416 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 748727003417 active site 748727003418 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748727003419 dimer interface [polypeptide binding]; other site 748727003420 substrate binding site [chemical binding]; other site 748727003421 catalytic residues [active] 748727003422 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 748727003423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727003424 non-specific DNA binding site [nucleotide binding]; other site 748727003425 salt bridge; other site 748727003426 sequence-specific DNA binding site [nucleotide binding]; other site 748727003427 Cupin domain; Region: Cupin_2; pfam07883 748727003428 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748727003429 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 748727003430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748727003431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727003432 dimer interface [polypeptide binding]; other site 748727003433 conserved gate region; other site 748727003434 ABC-ATPase subunit interface; other site 748727003435 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 748727003436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727003437 dimer interface [polypeptide binding]; other site 748727003438 conserved gate region; other site 748727003439 putative PBP binding loops; other site 748727003440 ABC-ATPase subunit interface; other site 748727003441 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748727003442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727003443 Walker A/P-loop; other site 748727003444 ATP binding site [chemical binding]; other site 748727003445 Q-loop/lid; other site 748727003446 ABC transporter signature motif; other site 748727003447 Walker B; other site 748727003448 D-loop; other site 748727003449 H-loop/switch region; other site 748727003450 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748727003451 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 748727003452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727003453 Walker A/P-loop; other site 748727003454 ATP binding site [chemical binding]; other site 748727003455 Q-loop/lid; other site 748727003456 ABC transporter signature motif; other site 748727003457 Walker B; other site 748727003458 D-loop; other site 748727003459 H-loop/switch region; other site 748727003460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748727003461 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 748727003462 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 748727003463 active site 748727003464 dimer interface [polypeptide binding]; other site 748727003465 Transcriptional regulator; Region: Rrf2; cl17282 748727003466 Rrf2 family protein; Region: rrf2_super; TIGR00738 748727003467 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748727003468 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748727003469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727003470 catalytic residue [active] 748727003471 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 748727003472 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 748727003473 trimerization site [polypeptide binding]; other site 748727003474 active site 748727003475 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 748727003476 PRC-barrel domain; Region: PRC; pfam05239 748727003477 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748727003478 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748727003479 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 748727003480 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 748727003481 motif 1; other site 748727003482 active site 748727003483 motif 2; other site 748727003484 motif 3; other site 748727003485 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748727003486 hypothetical protein; Provisional; Region: PRK05473 748727003487 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 748727003488 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 748727003489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727003490 metal binding site 2 [ion binding]; metal-binding site 748727003491 putative DNA binding helix; other site 748727003492 metal binding site 1 [ion binding]; metal-binding site 748727003493 dimer interface [polypeptide binding]; other site 748727003494 structural Zn2+ binding site [ion binding]; other site 748727003495 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748727003496 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727003497 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748727003498 hypothetical protein; Provisional; Region: PRK13676 748727003499 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 748727003500 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 748727003501 G1 box; other site 748727003502 putative GEF interaction site [polypeptide binding]; other site 748727003503 GTP/Mg2+ binding site [chemical binding]; other site 748727003504 Switch I region; other site 748727003505 G2 box; other site 748727003506 G3 box; other site 748727003507 Switch II region; other site 748727003508 G4 box; other site 748727003509 G5 box; other site 748727003510 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 748727003511 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 748727003512 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 748727003513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727003514 S-adenosylmethionine binding site [chemical binding]; other site 748727003515 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 748727003516 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 748727003517 Peptidase family U32; Region: Peptidase_U32; pfam01136 748727003518 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 748727003519 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748727003520 sporulation sigma factor SigK; Reviewed; Region: PRK05803 748727003521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727003522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727003523 DNA binding residues [nucleotide binding] 748727003524 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 748727003525 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 748727003526 Walker A motif; other site 748727003527 ATP binding site [chemical binding]; other site 748727003528 Walker B motif; other site 748727003529 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748727003530 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 748727003531 DXD motif; other site 748727003532 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 748727003533 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727003534 nucleotide binding site [chemical binding]; other site 748727003535 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 748727003536 Cell division protein FtsA; Region: FtsA; pfam14450 748727003537 cell division protein FtsZ; Validated; Region: PRK09330 748727003538 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 748727003539 nucleotide binding site [chemical binding]; other site 748727003540 SulA interaction site; other site 748727003541 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 748727003542 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 748727003543 sporulation sigma factor SigE; Reviewed; Region: PRK08301 748727003544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727003545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727003546 DNA binding residues [nucleotide binding] 748727003547 sporulation sigma factor SigG; Reviewed; Region: PRK08215 748727003548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727003549 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748727003550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727003551 DNA binding residues [nucleotide binding] 748727003552 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 748727003553 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 748727003554 ATP cone domain; Region: ATP-cone; pfam03477 748727003555 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 748727003556 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 748727003557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727003558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727003559 active site 748727003560 phosphorylation site [posttranslational modification] 748727003561 intermolecular recognition site; other site 748727003562 dimerization interface [polypeptide binding]; other site 748727003563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727003564 DNA binding site [nucleotide binding] 748727003565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727003566 dimerization interface [polypeptide binding]; other site 748727003567 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 748727003568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727003569 dimer interface [polypeptide binding]; other site 748727003570 phosphorylation site [posttranslational modification] 748727003571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727003572 ATP binding site [chemical binding]; other site 748727003573 Mg2+ binding site [ion binding]; other site 748727003574 G-X-G motif; other site 748727003575 PBP superfamily domain; Region: PBP_like_2; cl17296 748727003576 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 748727003577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727003578 dimer interface [polypeptide binding]; other site 748727003579 conserved gate region; other site 748727003580 putative PBP binding loops; other site 748727003581 ABC-ATPase subunit interface; other site 748727003582 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 748727003583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727003584 dimer interface [polypeptide binding]; other site 748727003585 conserved gate region; other site 748727003586 putative PBP binding loops; other site 748727003587 ABC-ATPase subunit interface; other site 748727003588 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 748727003589 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 748727003590 Walker A/P-loop; other site 748727003591 ATP binding site [chemical binding]; other site 748727003592 Q-loop/lid; other site 748727003593 ABC transporter signature motif; other site 748727003594 Walker B; other site 748727003595 D-loop; other site 748727003596 H-loop/switch region; other site 748727003597 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 748727003598 PhoU domain; Region: PhoU; pfam01895 748727003599 PhoU domain; Region: PhoU; pfam01895 748727003600 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 748727003601 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 748727003602 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 748727003603 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 748727003604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727003605 FeS/SAM binding site; other site 748727003606 Protein of unknown function (DUF512); Region: DUF512; pfam04459 748727003607 GTP-binding protein Der; Reviewed; Region: PRK00093 748727003608 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 748727003609 G1 box; other site 748727003610 GTP/Mg2+ binding site [chemical binding]; other site 748727003611 Switch I region; other site 748727003612 G2 box; other site 748727003613 Switch II region; other site 748727003614 G3 box; other site 748727003615 G4 box; other site 748727003616 G5 box; other site 748727003617 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 748727003618 G1 box; other site 748727003619 GTP/Mg2+ binding site [chemical binding]; other site 748727003620 Switch I region; other site 748727003621 G2 box; other site 748727003622 G3 box; other site 748727003623 Switch II region; other site 748727003624 G4 box; other site 748727003625 G5 box; other site 748727003626 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 748727003627 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 748727003628 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 748727003629 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 748727003630 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 748727003631 hypothetical protein; Provisional; Region: PRK11820 748727003632 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 748727003633 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 748727003634 hypothetical protein; Provisional; Region: PRK04323 748727003635 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 748727003636 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 748727003637 catalytic site [active] 748727003638 G-X2-G-X-G-K; other site 748727003639 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 748727003640 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 748727003641 Flavoprotein; Region: Flavoprotein; pfam02441 748727003642 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 748727003643 primosome assembly protein PriA; Validated; Region: PRK05580 748727003644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727003645 ATP binding site [chemical binding]; other site 748727003646 putative Mg++ binding site [ion binding]; other site 748727003647 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 748727003648 helicase superfamily c-terminal domain; Region: HELICc; smart00490 748727003649 ATP-binding site [chemical binding]; other site 748727003650 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748727003651 active site 748727003652 catalytic residues [active] 748727003653 metal binding site [ion binding]; metal-binding site 748727003654 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 748727003655 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 748727003656 putative active site [active] 748727003657 substrate binding site [chemical binding]; other site 748727003658 putative cosubstrate binding site; other site 748727003659 catalytic site [active] 748727003660 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 748727003661 substrate binding site [chemical binding]; other site 748727003662 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 748727003663 16S rRNA methyltransferase B; Provisional; Region: PRK14902 748727003664 NusB family; Region: NusB; pfam01029 748727003665 putative RNA binding site [nucleotide binding]; other site 748727003666 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 748727003667 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 748727003668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727003669 FeS/SAM binding site; other site 748727003670 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 748727003671 active site 748727003672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 748727003673 Catalytic domain of Protein Kinases; Region: PKc; cd00180 748727003674 active site 748727003675 ATP binding site [chemical binding]; other site 748727003676 substrate binding site [chemical binding]; other site 748727003677 activation loop (A-loop); other site 748727003678 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748727003679 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748727003680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748727003681 GTPase RsgA; Reviewed; Region: PRK00098 748727003682 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 748727003683 RNA binding site [nucleotide binding]; other site 748727003684 homodimer interface [polypeptide binding]; other site 748727003685 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 748727003686 GTPase/Zn-binding domain interface [polypeptide binding]; other site 748727003687 GTP/Mg2+ binding site [chemical binding]; other site 748727003688 G4 box; other site 748727003689 G5 box; other site 748727003690 G1 box; other site 748727003691 Switch I region; other site 748727003692 G2 box; other site 748727003693 G3 box; other site 748727003694 Switch II region; other site 748727003695 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 748727003696 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748727003697 substrate binding site [chemical binding]; other site 748727003698 hexamer interface [polypeptide binding]; other site 748727003699 metal binding site [ion binding]; metal-binding site 748727003700 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 748727003701 Thiamine pyrophosphokinase; Region: TPK; cd07995 748727003702 active site 748727003703 dimerization interface [polypeptide binding]; other site 748727003704 thiamine binding site [chemical binding]; other site 748727003705 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 748727003706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 748727003707 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 748727003708 DAK2 domain; Region: Dak2; pfam02734 748727003709 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 748727003710 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 748727003711 ssDNA binding site; other site 748727003712 generic binding surface II; other site 748727003713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727003714 ATP binding site [chemical binding]; other site 748727003715 putative Mg++ binding site [ion binding]; other site 748727003716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727003717 nucleotide binding region [chemical binding]; other site 748727003718 ATP-binding site [chemical binding]; other site 748727003719 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 748727003720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727003721 S-adenosylmethionine binding site [chemical binding]; other site 748727003722 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 748727003723 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 748727003724 active site 748727003725 (T/H)XGH motif; other site 748727003726 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 748727003727 hypothetical protein; Provisional; Region: PRK13670 748727003728 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 748727003729 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 748727003730 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748727003731 propionate/acetate kinase; Provisional; Region: PRK12379 748727003732 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 748727003733 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 748727003734 putative phosphate acyltransferase; Provisional; Region: PRK05331 748727003735 acyl carrier protein; Provisional; Region: acpP; PRK00982 748727003736 ribonuclease III; Reviewed; Region: rnc; PRK00102 748727003737 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 748727003738 dimerization interface [polypeptide binding]; other site 748727003739 active site 748727003740 metal binding site [ion binding]; metal-binding site 748727003741 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 748727003742 dsRNA binding site [nucleotide binding]; other site 748727003743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727003744 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 748727003745 FeS/SAM binding site; other site 748727003746 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 748727003747 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748727003748 Walker A/P-loop; other site 748727003749 ATP binding site [chemical binding]; other site 748727003750 Q-loop/lid; other site 748727003751 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 748727003752 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748727003753 ABC transporter signature motif; other site 748727003754 Walker B; other site 748727003755 D-loop; other site 748727003756 H-loop/switch region; other site 748727003757 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 748727003758 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 748727003759 P loop; other site 748727003760 GTP binding site [chemical binding]; other site 748727003761 putative DNA-binding protein; Validated; Region: PRK00118 748727003762 signal recognition particle protein; Provisional; Region: PRK10867 748727003763 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 748727003764 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 748727003765 P loop; other site 748727003766 GTP binding site [chemical binding]; other site 748727003767 Signal peptide binding domain; Region: SRP_SPB; pfam02978 748727003768 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 748727003769 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 748727003770 hypothetical protein; Provisional; Region: PRK00468 748727003771 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 748727003772 RimM N-terminal domain; Region: RimM; pfam01782 748727003773 PRC-barrel domain; Region: PRC; pfam05239 748727003774 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 748727003775 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 748727003776 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748727003777 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748727003778 Catalytic site [active] 748727003779 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 748727003780 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 748727003781 GTP/Mg2+ binding site [chemical binding]; other site 748727003782 G4 box; other site 748727003783 G5 box; other site 748727003784 G1 box; other site 748727003785 Switch I region; other site 748727003786 G2 box; other site 748727003787 G3 box; other site 748727003788 Switch II region; other site 748727003789 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 748727003790 RNA/DNA hybrid binding site [nucleotide binding]; other site 748727003791 active site 748727003792 hypothetical protein; Reviewed; Region: PRK12497 748727003793 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 748727003794 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 748727003795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727003796 Walker A motif; other site 748727003797 ATP binding site [chemical binding]; other site 748727003798 Walker B motif; other site 748727003799 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 748727003800 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 748727003801 DNA protecting protein DprA; Region: dprA; TIGR00732 748727003802 DNA topoisomerase I; Validated; Region: PRK05582 748727003803 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 748727003804 active site 748727003805 interdomain interaction site; other site 748727003806 putative metal-binding site [ion binding]; other site 748727003807 nucleotide binding site [chemical binding]; other site 748727003808 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 748727003809 domain I; other site 748727003810 DNA binding groove [nucleotide binding] 748727003811 phosphate binding site [ion binding]; other site 748727003812 domain II; other site 748727003813 domain III; other site 748727003814 nucleotide binding site [chemical binding]; other site 748727003815 catalytic site [active] 748727003816 domain IV; other site 748727003817 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748727003818 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748727003819 transcriptional repressor CodY; Validated; Region: PRK04158 748727003820 CodY GAF-like domain; Region: CodY; pfam06018 748727003821 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 748727003822 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 748727003823 rRNA interaction site [nucleotide binding]; other site 748727003824 S8 interaction site; other site 748727003825 putative laminin-1 binding site; other site 748727003826 elongation factor Ts; Provisional; Region: tsf; PRK09377 748727003827 UBA/TS-N domain; Region: UBA; pfam00627 748727003828 Elongation factor TS; Region: EF_TS; pfam00889 748727003829 Elongation factor TS; Region: EF_TS; pfam00889 748727003830 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 748727003831 putative nucleotide binding site [chemical binding]; other site 748727003832 uridine monophosphate binding site [chemical binding]; other site 748727003833 homohexameric interface [polypeptide binding]; other site 748727003834 ribosome recycling factor; Reviewed; Region: frr; PRK00083 748727003835 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 748727003836 hinge region; other site 748727003837 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 748727003838 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 748727003839 catalytic residue [active] 748727003840 putative FPP diphosphate binding site; other site 748727003841 putative FPP binding hydrophobic cleft; other site 748727003842 dimer interface [polypeptide binding]; other site 748727003843 putative IPP diphosphate binding site; other site 748727003844 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 748727003845 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 748727003846 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 748727003847 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 748727003848 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 748727003849 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 748727003850 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 748727003851 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 748727003852 active site 748727003853 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 748727003854 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 748727003855 putative substrate binding region [chemical binding]; other site 748727003856 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 748727003857 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 748727003858 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 748727003859 Sm and related proteins; Region: Sm_like; cl00259 748727003860 ribosome maturation protein RimP; Reviewed; Region: PRK00092 748727003861 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 748727003862 putative oligomer interface [polypeptide binding]; other site 748727003863 putative RNA binding site [nucleotide binding]; other site 748727003864 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 748727003865 NusA N-terminal domain; Region: NusA_N; pfam08529 748727003866 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 748727003867 RNA binding site [nucleotide binding]; other site 748727003868 homodimer interface [polypeptide binding]; other site 748727003869 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 748727003870 G-X-X-G motif; other site 748727003871 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 748727003872 G-X-X-G motif; other site 748727003873 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 748727003874 putative RNA binding cleft [nucleotide binding]; other site 748727003875 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 748727003876 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748727003877 translation initiation factor IF-2; Region: IF-2; TIGR00487 748727003878 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748727003879 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 748727003880 G1 box; other site 748727003881 putative GEF interaction site [polypeptide binding]; other site 748727003882 GTP/Mg2+ binding site [chemical binding]; other site 748727003883 Switch I region; other site 748727003884 G2 box; other site 748727003885 G3 box; other site 748727003886 Switch II region; other site 748727003887 G4 box; other site 748727003888 G5 box; other site 748727003889 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 748727003890 Translation-initiation factor 2; Region: IF-2; pfam11987 748727003891 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 748727003892 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 748727003893 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 748727003894 DHH family; Region: DHH; pfam01368 748727003895 DHHA1 domain; Region: DHHA1; pfam02272 748727003896 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 748727003897 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 748727003898 RNA binding site [nucleotide binding]; other site 748727003899 active site 748727003900 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 748727003901 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 748727003902 active site 748727003903 Riboflavin kinase; Region: Flavokinase; pfam01687 748727003904 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 748727003905 16S/18S rRNA binding site [nucleotide binding]; other site 748727003906 S13e-L30e interaction site [polypeptide binding]; other site 748727003907 25S rRNA binding site [nucleotide binding]; other site 748727003908 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 748727003909 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 748727003910 RNase E interface [polypeptide binding]; other site 748727003911 trimer interface [polypeptide binding]; other site 748727003912 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 748727003913 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 748727003914 RNase E interface [polypeptide binding]; other site 748727003915 trimer interface [polypeptide binding]; other site 748727003916 active site 748727003917 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 748727003918 putative nucleic acid binding region [nucleotide binding]; other site 748727003919 G-X-X-G motif; other site 748727003920 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 748727003921 RNA binding site [nucleotide binding]; other site 748727003922 domain interface; other site 748727003923 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 748727003924 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 748727003925 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748727003926 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 748727003927 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 748727003928 Clp protease; Region: CLP_protease; pfam00574 748727003929 active site 748727003930 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 748727003931 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 748727003932 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 748727003933 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 748727003934 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 748727003935 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748727003936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727003937 FeS/SAM binding site; other site 748727003938 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 748727003939 recombinase A; Provisional; Region: recA; PRK09354 748727003940 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 748727003941 hexamer interface [polypeptide binding]; other site 748727003942 Walker A motif; other site 748727003943 ATP binding site [chemical binding]; other site 748727003944 Walker B motif; other site 748727003945 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 748727003946 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 748727003947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727003948 Zn2+ binding site [ion binding]; other site 748727003949 Mg2+ binding site [ion binding]; other site 748727003950 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 748727003951 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 748727003952 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 748727003953 aspartate aminotransferase; Provisional; Region: PRK05764 748727003954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727003956 homodimer interface [polypeptide binding]; other site 748727003957 catalytic residue [active] 748727003958 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748727003959 dimerization domain swap beta strand [polypeptide binding]; other site 748727003960 regulatory protein interface [polypeptide binding]; other site 748727003961 active site 748727003962 regulatory phosphorylation site [posttranslational modification]; other site 748727003963 Uncharacterized conserved protein [Function unknown]; Region: COG2155 748727003964 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 748727003965 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 748727003966 tetramer interface [polypeptide binding]; other site 748727003967 active site 748727003968 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 748727003969 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748727003970 active site 748727003971 HIGH motif; other site 748727003972 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748727003973 active site 748727003974 KMSKS motif; other site 748727003975 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 748727003976 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 748727003977 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 748727003978 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748727003979 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 748727003980 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 748727003981 putative active site [active] 748727003982 putative CoA binding site [chemical binding]; other site 748727003983 nudix motif; other site 748727003984 metal binding site [ion binding]; metal-binding site 748727003985 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 748727003986 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 748727003987 active site 748727003988 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 748727003989 thiamine phosphate binding site [chemical binding]; other site 748727003990 active site 748727003991 pyrophosphate binding site [ion binding]; other site 748727003992 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 748727003993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727003994 active site 748727003995 phosphorylation site [posttranslational modification] 748727003996 intermolecular recognition site; other site 748727003997 dimerization interface [polypeptide binding]; other site 748727003998 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 748727003999 Cache domain; Region: Cache_1; pfam02743 748727004000 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727004001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727004002 dimerization interface [polypeptide binding]; other site 748727004003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004004 dimer interface [polypeptide binding]; other site 748727004005 putative CheW interface [polypeptide binding]; other site 748727004006 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727004007 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 748727004008 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 748727004009 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 748727004010 active site 748727004011 catalytic residues [active] 748727004012 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748727004013 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 748727004014 conserved cys residue [active] 748727004015 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 748727004016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 748727004017 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 748727004018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004019 putative substrate translocation pore; other site 748727004020 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748727004021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 748727004022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727004023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727004024 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727004025 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 748727004026 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 748727004027 active site 748727004028 catalytic residues [active] 748727004029 RNA polymerase factor sigma-70; Validated; Region: PRK06811 748727004030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727004031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727004032 DNA binding residues [nucleotide binding] 748727004033 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 748727004034 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 748727004035 Transcriptional regulator [Transcription]; Region: IclR; COG1414 748727004036 Bacterial transcriptional regulator; Region: IclR; pfam01614 748727004037 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 748727004038 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 748727004039 active site 748727004040 intersubunit interface [polypeptide binding]; other site 748727004041 catalytic residue [active] 748727004042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004043 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 748727004044 putative substrate translocation pore; other site 748727004045 AAA domain; Region: AAA_33; pfam13671 748727004046 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 748727004047 active site 748727004048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748727004049 active site 748727004050 catalytic residues [active] 748727004051 metal binding site [ion binding]; metal-binding site 748727004052 hypothetical protein; Provisional; Region: PRK03881 748727004053 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 748727004054 AMMECR1; Region: AMMECR1; pfam01871 748727004055 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 748727004056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727004057 FeS/SAM binding site; other site 748727004058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727004059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004060 sequence-specific DNA binding site [nucleotide binding]; other site 748727004061 salt bridge; other site 748727004062 Cupin domain; Region: Cupin_2; pfam07883 748727004063 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 748727004064 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 748727004065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727004066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004067 non-specific DNA binding site [nucleotide binding]; other site 748727004068 salt bridge; other site 748727004069 sequence-specific DNA binding site [nucleotide binding]; other site 748727004070 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 748727004071 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 748727004072 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 748727004073 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 748727004074 ArsC family; Region: ArsC; pfam03960 748727004075 catalytic residue [active] 748727004076 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748727004077 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748727004078 Cache domain; Region: Cache_1; pfam02743 748727004079 HAMP domain; Region: HAMP; pfam00672 748727004080 dimerization interface [polypeptide binding]; other site 748727004081 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727004082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004083 dimer interface [polypeptide binding]; other site 748727004084 putative CheW interface [polypeptide binding]; other site 748727004085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727004087 dimer interface [polypeptide binding]; other site 748727004088 phosphorylation site [posttranslational modification] 748727004089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004090 ATP binding site [chemical binding]; other site 748727004091 Mg2+ binding site [ion binding]; other site 748727004092 G-X-G motif; other site 748727004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004095 active site 748727004096 phosphorylation site [posttranslational modification] 748727004097 intermolecular recognition site; other site 748727004098 dimerization interface [polypeptide binding]; other site 748727004099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004100 DNA binding site [nucleotide binding] 748727004101 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727004102 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 748727004103 Walker A/P-loop; other site 748727004104 ATP binding site [chemical binding]; other site 748727004105 Q-loop/lid; other site 748727004106 ABC transporter signature motif; other site 748727004107 Walker B; other site 748727004108 D-loop; other site 748727004109 H-loop/switch region; other site 748727004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 748727004111 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727004112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 748727004113 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727004114 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727004115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004116 active site 748727004117 phosphorylation site [posttranslational modification] 748727004118 intermolecular recognition site; other site 748727004119 dimerization interface [polypeptide binding]; other site 748727004120 LytTr DNA-binding domain; Region: LytTR; smart00850 748727004121 Cache domain; Region: Cache_1; pfam02743 748727004122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727004123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004124 dimer interface [polypeptide binding]; other site 748727004125 putative CheW interface [polypeptide binding]; other site 748727004126 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 748727004127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727004128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004129 dimer interface [polypeptide binding]; other site 748727004130 putative CheW interface [polypeptide binding]; other site 748727004131 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 748727004132 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 748727004133 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 748727004134 Na binding site [ion binding]; other site 748727004135 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 748727004136 Ligand binding site [chemical binding]; other site 748727004137 Electron transfer flavoprotein domain; Region: ETF; pfam01012 748727004138 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 748727004139 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 748727004140 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 748727004141 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 748727004142 FAD binding domain; Region: FAD_binding_4; pfam01565 748727004143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 748727004144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727004145 DNA-binding site [nucleotide binding]; DNA binding site 748727004146 FCD domain; Region: FCD; pfam07729 748727004147 OPT oligopeptide transporter protein; Region: OPT; cl14607 748727004148 OPT oligopeptide transporter protein; Region: OPT; cl14607 748727004149 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 748727004150 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 748727004151 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 748727004152 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 748727004153 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 748727004154 G1 box; other site 748727004155 GTP/Mg2+ binding site [chemical binding]; other site 748727004156 Switch I region; other site 748727004157 G2 box; other site 748727004158 G3 box; other site 748727004159 Switch II region; other site 748727004160 G4 box; other site 748727004161 G5 box; other site 748727004162 Nucleoside recognition; Region: Gate; pfam07670 748727004163 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 748727004164 Nucleoside recognition; Region: Gate; pfam07670 748727004165 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 748727004166 flavodoxin; Provisional; Region: PRK05568 748727004167 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 748727004168 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 748727004169 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727004170 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 748727004171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004172 salt bridge; other site 748727004173 non-specific DNA binding site [nucleotide binding]; other site 748727004174 sequence-specific DNA binding site [nucleotide binding]; other site 748727004175 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 748727004176 B12 binding site [chemical binding]; other site 748727004177 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748727004178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727004179 ABC transporter signature motif; other site 748727004180 Walker B; other site 748727004181 D-loop; other site 748727004182 H-loop/switch region; other site 748727004183 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727004184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727004185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727004186 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 748727004187 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727004188 HAMP domain; Region: HAMP; pfam00672 748727004189 dimerization interface [polypeptide binding]; other site 748727004190 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004191 dimer interface [polypeptide binding]; other site 748727004192 putative CheW interface [polypeptide binding]; other site 748727004193 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 748727004194 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727004195 DNA binding residues [nucleotide binding] 748727004196 dimer interface [polypeptide binding]; other site 748727004197 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 748727004198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727004199 MarR family; Region: MarR; pfam01047 748727004200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727004202 putative substrate translocation pore; other site 748727004203 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748727004204 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748727004205 ligand binding site [chemical binding]; other site 748727004206 flexible hinge region; other site 748727004207 short chain dehydrogenase; Provisional; Region: PRK06914 748727004208 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 748727004209 NADP binding site [chemical binding]; other site 748727004210 active site 748727004211 steroid binding site; other site 748727004212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004214 active site 748727004215 phosphorylation site [posttranslational modification] 748727004216 intermolecular recognition site; other site 748727004217 dimerization interface [polypeptide binding]; other site 748727004218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004219 DNA binding site [nucleotide binding] 748727004220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004222 ATP binding site [chemical binding]; other site 748727004223 Mg2+ binding site [ion binding]; other site 748727004224 G-X-G motif; other site 748727004225 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727004226 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727004227 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 748727004228 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727004229 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727004230 DNA binding residues [nucleotide binding] 748727004231 putative dimer interface [polypeptide binding]; other site 748727004232 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727004233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727004234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748727004235 active site 748727004236 metal binding site [ion binding]; metal-binding site 748727004237 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727004238 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727004239 Walker A/P-loop; other site 748727004240 ATP binding site [chemical binding]; other site 748727004241 Q-loop/lid; other site 748727004242 ABC transporter signature motif; other site 748727004243 Walker B; other site 748727004244 D-loop; other site 748727004245 H-loop/switch region; other site 748727004246 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727004247 FtsX-like permease family; Region: FtsX; pfam02687 748727004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727004250 putative substrate translocation pore; other site 748727004251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727004253 putative substrate translocation pore; other site 748727004254 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 748727004255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727004256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727004257 homodimer interface [polypeptide binding]; other site 748727004258 catalytic residue [active] 748727004259 FtsX-like permease family; Region: FtsX; pfam02687 748727004260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727004261 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727004262 FtsX-like permease family; Region: FtsX; pfam02687 748727004263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727004264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727004265 Walker A/P-loop; other site 748727004266 ATP binding site [chemical binding]; other site 748727004267 Q-loop/lid; other site 748727004268 ABC transporter signature motif; other site 748727004269 Walker B; other site 748727004270 D-loop; other site 748727004271 H-loop/switch region; other site 748727004272 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 748727004273 Part of AAA domain; Region: AAA_19; pfam13245 748727004274 Family description; Region: UvrD_C_2; pfam13538 748727004275 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 748727004276 active site 748727004277 8-oxo-dGMP binding site [chemical binding]; other site 748727004278 nudix motif; other site 748727004279 metal binding site [ion binding]; metal-binding site 748727004280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727004281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727004282 phosphoenolpyruvate synthase; Validated; Region: PRK06241 748727004283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 748727004284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748727004285 VanZ like family; Region: VanZ; cl01971 748727004286 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748727004287 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 748727004288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727004290 dimer interface [polypeptide binding]; other site 748727004291 phosphorylation site [posttranslational modification] 748727004292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004293 ATP binding site [chemical binding]; other site 748727004294 Mg2+ binding site [ion binding]; other site 748727004295 G-X-G motif; other site 748727004296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004298 active site 748727004299 phosphorylation site [posttranslational modification] 748727004300 intermolecular recognition site; other site 748727004301 dimerization interface [polypeptide binding]; other site 748727004302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004303 DNA binding site [nucleotide binding] 748727004304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004306 active site 748727004307 phosphorylation site [posttranslational modification] 748727004308 intermolecular recognition site; other site 748727004309 dimerization interface [polypeptide binding]; other site 748727004310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004311 DNA binding site [nucleotide binding] 748727004312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004314 ATP binding site [chemical binding]; other site 748727004315 Mg2+ binding site [ion binding]; other site 748727004316 G-X-G motif; other site 748727004317 Peptidase family S41; Region: Peptidase_S41; pfam03572 748727004318 Active site serine [active] 748727004319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727004320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727004321 Walker A/P-loop; other site 748727004322 ATP binding site [chemical binding]; other site 748727004323 Q-loop/lid; other site 748727004324 ABC transporter signature motif; other site 748727004325 Walker B; other site 748727004326 D-loop; other site 748727004327 H-loop/switch region; other site 748727004328 FtsX-like permease family; Region: FtsX; pfam02687 748727004329 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 748727004330 Protein of unknown function (DUF429); Region: DUF429; pfam04250 748727004331 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 748727004332 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 748727004333 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 748727004334 HSP70 interaction site [polypeptide binding]; other site 748727004335 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 748727004336 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 748727004337 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 748727004338 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 748727004339 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 748727004340 AAA-like domain; Region: AAA_10; pfam12846 748727004341 Domain of unknown function DUF87; Region: DUF87; pfam01935 748727004342 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748727004343 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748727004344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727004345 catalytic residue [active] 748727004346 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 748727004347 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 748727004348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727004349 Walker A/P-loop; other site 748727004350 ATP binding site [chemical binding]; other site 748727004351 hypothetical protein; Provisional; Region: PRK06850 748727004352 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 748727004353 Active Sites [active] 748727004354 DNA-sulfur modification-associated; Region: DndB; cl17621 748727004355 DGQHR domain; Region: DGQHR; TIGR03187 748727004356 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 748727004357 Low molecular weight phosphatase family; Region: LMWPc; cd00115 748727004358 active site 748727004359 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 748727004360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727004361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727004362 metal binding site [ion binding]; metal-binding site 748727004363 active site 748727004364 I-site; other site 748727004365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727004366 SWIM zinc finger; Region: SWIM; pfam04434 748727004367 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 748727004368 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 748727004369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727004370 ATP binding site [chemical binding]; other site 748727004371 putative Mg++ binding site [ion binding]; other site 748727004372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727004373 nucleotide binding region [chemical binding]; other site 748727004374 ATP-binding site [chemical binding]; other site 748727004375 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 748727004376 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727004377 VanW like protein; Region: VanW; pfam04294 748727004378 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727004379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004380 non-specific DNA binding site [nucleotide binding]; other site 748727004381 salt bridge; other site 748727004382 sequence-specific DNA binding site [nucleotide binding]; other site 748727004383 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 748727004384 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727004385 catalytic loop [active] 748727004386 iron binding site [ion binding]; other site 748727004387 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 748727004388 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748727004389 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727004390 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 748727004391 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748727004392 dimer interface [polypeptide binding]; other site 748727004393 [2Fe-2S] cluster binding site [ion binding]; other site 748727004394 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 748727004395 SLBB domain; Region: SLBB; pfam10531 748727004396 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748727004397 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727004398 4Fe-4S binding domain; Region: Fer4; pfam00037 748727004399 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727004400 4Fe-4S binding domain; Region: Fer4; pfam00037 748727004401 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 748727004402 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 748727004403 putative dimer interface [polypeptide binding]; other site 748727004404 [2Fe-2S] cluster binding site [ion binding]; other site 748727004405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727004406 MarR family; Region: MarR_2; pfam12802 748727004407 MarR family; Region: MarR_2; cl17246 748727004408 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 748727004409 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748727004410 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 748727004411 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748727004412 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 748727004413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 748727004414 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cl07841 748727004415 oligomer interface [polypeptide binding]; other site 748727004416 active site 748727004417 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 748727004418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 748727004419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727004420 active site 748727004421 DNA binding site [nucleotide binding] 748727004422 Int/Topo IB signature motif; other site 748727004423 PAS fold; Region: PAS_3; pfam08447 748727004424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727004425 metal binding site [ion binding]; metal-binding site 748727004426 active site 748727004427 I-site; other site 748727004428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727004429 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727004430 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727004431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727004432 dimerization interface [polypeptide binding]; other site 748727004433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004434 dimer interface [polypeptide binding]; other site 748727004435 putative CheW interface [polypeptide binding]; other site 748727004436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004438 D-galactonate transporter; Region: 2A0114; TIGR00893 748727004439 putative substrate translocation pore; other site 748727004440 MORN repeat; Region: MORN; cl14787 748727004441 MORN repeat; Region: MORN; cl14787 748727004442 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727004443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727004444 substrate binding pocket [chemical binding]; other site 748727004445 membrane-bound complex binding site; other site 748727004446 PAS fold; Region: PAS_4; pfam08448 748727004447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 748727004448 putative active site [active] 748727004449 heme pocket [chemical binding]; other site 748727004450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727004451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727004452 metal binding site [ion binding]; metal-binding site 748727004453 active site 748727004454 I-site; other site 748727004455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727004456 Zn2+ binding site [ion binding]; other site 748727004457 Mg2+ binding site [ion binding]; other site 748727004458 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 748727004459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 748727004460 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 748727004461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727004462 DNA binding residues [nucleotide binding] 748727004463 dimer interface [polypeptide binding]; other site 748727004464 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727004465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727004466 dimerization interface [polypeptide binding]; other site 748727004467 putative Zn2+ binding site [ion binding]; other site 748727004468 putative DNA binding site [nucleotide binding]; other site 748727004469 Predicted esterase [General function prediction only]; Region: COG0400 748727004470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748727004471 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 748727004472 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 748727004473 N- and C-terminal domain interface [polypeptide binding]; other site 748727004474 putative active site [active] 748727004475 MgATP binding site [chemical binding]; other site 748727004476 catalytic site [active] 748727004477 metal binding site [ion binding]; metal-binding site 748727004478 putative xylulose binding site [chemical binding]; other site 748727004479 putative homodimer interface [polypeptide binding]; other site 748727004480 CAAX protease self-immunity; Region: Abi; pfam02517 748727004481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004483 active site 748727004484 phosphorylation site [posttranslational modification] 748727004485 intermolecular recognition site; other site 748727004486 dimerization interface [polypeptide binding]; other site 748727004487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004488 DNA binding site [nucleotide binding] 748727004489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727004491 dimerization interface [polypeptide binding]; other site 748727004492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727004493 dimer interface [polypeptide binding]; other site 748727004494 phosphorylation site [posttranslational modification] 748727004495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004496 ATP binding site [chemical binding]; other site 748727004497 Mg2+ binding site [ion binding]; other site 748727004498 G-X-G motif; other site 748727004499 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727004500 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727004501 active site 748727004502 FMN binding site [chemical binding]; other site 748727004503 substrate binding site [chemical binding]; other site 748727004504 putative catalytic residue [active] 748727004505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727004506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727004507 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727004508 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 748727004509 active site 748727004510 metal binding site [ion binding]; metal-binding site 748727004511 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 748727004512 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727004513 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 748727004514 nudix motif; other site 748727004515 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 748727004516 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 748727004517 MutS domain III; Region: MutS_III; pfam05192 748727004518 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 748727004519 Walker A/P-loop; other site 748727004520 ATP binding site [chemical binding]; other site 748727004521 Q-loop/lid; other site 748727004522 ABC transporter signature motif; other site 748727004523 Walker B; other site 748727004524 D-loop; other site 748727004525 H-loop/switch region; other site 748727004526 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748727004527 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 748727004528 putative oligomer interface [polypeptide binding]; other site 748727004529 putative active site [active] 748727004530 metal binding site [ion binding]; metal-binding site 748727004531 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 748727004532 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 748727004533 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748727004534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727004535 Walker A/P-loop; other site 748727004536 ATP binding site [chemical binding]; other site 748727004537 Q-loop/lid; other site 748727004538 ABC transporter signature motif; other site 748727004539 Walker B; other site 748727004540 D-loop; other site 748727004541 H-loop/switch region; other site 748727004542 threonine dehydratase; Provisional; Region: PRK08198 748727004543 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 748727004544 tetramer interface [polypeptide binding]; other site 748727004545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727004546 catalytic residue [active] 748727004547 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 748727004548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727004549 active site 748727004550 xanthine permease; Region: pbuX; TIGR03173 748727004551 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 748727004552 catalytic residues [active] 748727004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727004554 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 748727004555 Walker A motif; other site 748727004556 ATP binding site [chemical binding]; other site 748727004557 Walker B motif; other site 748727004558 arginine finger; other site 748727004559 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727004560 MarR family; Region: MarR_2; pfam12802 748727004561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727004562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727004563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727004564 Walker A/P-loop; other site 748727004565 ATP binding site [chemical binding]; other site 748727004566 Q-loop/lid; other site 748727004567 ABC transporter signature motif; other site 748727004568 Walker B; other site 748727004569 D-loop; other site 748727004570 H-loop/switch region; other site 748727004571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727004572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727004573 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748727004574 Walker A/P-loop; other site 748727004575 ATP binding site [chemical binding]; other site 748727004576 Q-loop/lid; other site 748727004577 ABC transporter signature motif; other site 748727004578 Walker B; other site 748727004579 D-loop; other site 748727004580 H-loop/switch region; other site 748727004581 Predicted transcriptional regulator [Transcription]; Region: COG2378 748727004582 HTH domain; Region: HTH_11; pfam08279 748727004583 WYL domain; Region: WYL; pfam13280 748727004584 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 748727004585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 748727004586 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727004587 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727004588 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748727004589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727004590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727004591 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 748727004592 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 748727004593 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727004594 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 748727004595 FMN binding site [chemical binding]; other site 748727004596 dimer interface [polypeptide binding]; other site 748727004597 hypothetical protein; Provisional; Region: PRK11171 748727004598 allantoate amidohydrolase; Reviewed; Region: PRK09290 748727004599 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 748727004600 active site 748727004601 metal binding site [ion binding]; metal-binding site 748727004602 dimer interface [polypeptide binding]; other site 748727004603 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 748727004604 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727004605 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727004606 carbamate kinase; Reviewed; Region: PRK12686 748727004607 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727004608 putative substrate binding site [chemical binding]; other site 748727004609 nucleotide binding site [chemical binding]; other site 748727004610 nucleotide binding site [chemical binding]; other site 748727004611 homodimer interface [polypeptide binding]; other site 748727004612 ketol-acid reductoisomerase; Provisional; Region: PRK05479 748727004613 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 748727004614 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 748727004615 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 748727004616 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 748727004617 Na binding site [ion binding]; other site 748727004618 putative substrate binding site [chemical binding]; other site 748727004619 allantoinase; Provisional; Region: PRK06189 748727004620 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 748727004621 active site 748727004622 allantoinase; Provisional; Region: PRK06189 748727004623 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 748727004624 active site 748727004625 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 748727004626 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 748727004627 Na binding site [ion binding]; other site 748727004628 putative substrate binding site [chemical binding]; other site 748727004629 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 748727004630 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 748727004631 putative FMN binding site [chemical binding]; other site 748727004632 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 748727004633 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 748727004634 HlyD family secretion protein; Region: HlyD; pfam00529 748727004635 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727004636 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727004637 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727004638 MarR family; Region: MarR_2; pfam12802 748727004639 L,D-transpeptidase; Provisional; Region: PRK10260 748727004640 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727004641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727004642 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748727004643 non-specific DNA interactions [nucleotide binding]; other site 748727004644 DNA binding site [nucleotide binding] 748727004645 sequence specific DNA binding site [nucleotide binding]; other site 748727004646 putative cAMP binding site [chemical binding]; other site 748727004647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004649 active site 748727004650 phosphorylation site [posttranslational modification] 748727004651 intermolecular recognition site; other site 748727004652 dimerization interface [polypeptide binding]; other site 748727004653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004654 DNA binding site [nucleotide binding] 748727004655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727004656 dimer interface [polypeptide binding]; other site 748727004657 phosphorylation site [posttranslational modification] 748727004658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004659 ATP binding site [chemical binding]; other site 748727004660 Mg2+ binding site [ion binding]; other site 748727004661 G-X-G motif; other site 748727004662 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727004663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727004664 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727004665 Walker A/P-loop; other site 748727004666 ATP binding site [chemical binding]; other site 748727004667 Q-loop/lid; other site 748727004668 ABC transporter signature motif; other site 748727004669 Walker B; other site 748727004670 D-loop; other site 748727004671 H-loop/switch region; other site 748727004672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727004673 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727004674 FtsX-like permease family; Region: FtsX; pfam02687 748727004675 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 748727004676 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727004677 DNA binding residues [nucleotide binding] 748727004678 dimer interface [polypeptide binding]; other site 748727004679 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 748727004680 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727004681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727004682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004683 dimer interface [polypeptide binding]; other site 748727004684 putative CheW interface [polypeptide binding]; other site 748727004685 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 748727004686 active site 748727004687 catalytic residues [active] 748727004688 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 748727004689 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 748727004690 putative [4Fe-4S] binding site [ion binding]; other site 748727004691 putative molybdopterin cofactor binding site [chemical binding]; other site 748727004692 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 748727004693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727004694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727004695 dimerization interface [polypeptide binding]; other site 748727004696 Uncharacterized conserved protein [Function unknown]; Region: COG3875 748727004697 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 748727004698 amphipathic channel; other site 748727004699 Asn-Pro-Ala signature motifs; other site 748727004700 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 748727004701 AIR carboxylase; Region: AIRC; cl00310 748727004702 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727004703 Spore germination protein; Region: Spore_permease; cl17796 748727004704 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727004705 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727004706 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 748727004707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 748727004708 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 748727004709 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 748727004710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727004711 dimerization interface [polypeptide binding]; other site 748727004712 putative DNA binding site [nucleotide binding]; other site 748727004713 putative Zn2+ binding site [ion binding]; other site 748727004714 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 748727004715 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 748727004716 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 748727004717 P loop; other site 748727004718 Nucleotide binding site [chemical binding]; other site 748727004719 DTAP/Switch II; other site 748727004720 Switch I; other site 748727004721 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 748727004722 P loop; other site 748727004723 Nucleotide binding site [chemical binding]; other site 748727004724 DTAP/Switch II; other site 748727004725 Switch I; other site 748727004726 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 748727004727 arsenical-resistance protein; Region: acr3; TIGR00832 748727004728 VanZ like family; Region: VanZ; pfam04892 748727004729 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 748727004730 serpin-like protein; Provisional; Region: PHA02660 748727004731 reactive center loop; other site 748727004732 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 748727004733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727004734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727004735 DNA binding residues [nucleotide binding] 748727004736 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 748727004737 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 748727004738 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 748727004739 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727004740 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727004741 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748727004742 PAS domain; Region: PAS_9; pfam13426 748727004743 PAS domain S-box; Region: sensory_box; TIGR00229 748727004744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727004745 putative active site [active] 748727004746 heme pocket [chemical binding]; other site 748727004747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727004748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727004749 metal binding site [ion binding]; metal-binding site 748727004750 active site 748727004751 I-site; other site 748727004752 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727004753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727004754 Zn2+ binding site [ion binding]; other site 748727004755 Mg2+ binding site [ion binding]; other site 748727004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 748727004757 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 748727004758 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 748727004759 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748727004760 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748727004761 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748727004762 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 748727004763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004764 putative substrate translocation pore; other site 748727004765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004766 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 748727004767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727004768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004769 active site 748727004770 phosphorylation site [posttranslational modification] 748727004771 intermolecular recognition site; other site 748727004772 dimerization interface [polypeptide binding]; other site 748727004773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727004774 DNA binding site [nucleotide binding] 748727004775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727004776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727004777 dimerization interface [polypeptide binding]; other site 748727004778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727004779 dimer interface [polypeptide binding]; other site 748727004780 phosphorylation site [posttranslational modification] 748727004781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727004782 ATP binding site [chemical binding]; other site 748727004783 Mg2+ binding site [ion binding]; other site 748727004784 G-X-G motif; other site 748727004785 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 748727004786 active site 748727004787 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748727004788 monogalactosyldiacylglycerol synthase; Region: PLN02605 748727004789 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 748727004790 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 748727004791 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 748727004792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727004793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004794 putative substrate translocation pore; other site 748727004795 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748727004796 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748727004797 Transglycosylase; Region: Transgly; pfam00912 748727004798 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 748727004799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727004800 Bacitracin resistance protein BacA; Region: BacA; pfam02673 748727004801 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 748727004802 Transglycosylase; Region: Transgly; pfam00912 748727004803 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 748727004804 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 748727004805 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748727004806 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 748727004807 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748727004808 active site 748727004809 MgtE intracellular N domain; Region: MgtE_N; pfam03448 748727004810 FOG: CBS domain [General function prediction only]; Region: COG0517 748727004811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 748727004812 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 748727004813 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 748727004814 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748727004815 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748727004816 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727004817 active site 748727004818 metal binding site [ion binding]; metal-binding site 748727004819 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727004820 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727004821 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727004822 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727004823 anthranilate synthase component I; Provisional; Region: PRK13570 748727004824 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 748727004825 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 748727004826 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 748727004827 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 748727004828 glutamine binding [chemical binding]; other site 748727004829 catalytic triad [active] 748727004830 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 748727004831 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 748727004832 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 748727004833 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 748727004834 active site 748727004835 product (indole) binding pocket [chemical binding]; other site 748727004836 substrate (anthranilate) binding pocket [chemical binding]; other site 748727004837 ribulose/triose binding site [chemical binding]; other site 748727004838 phosphate binding site [ion binding]; other site 748727004839 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 748727004840 active site 748727004841 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 748727004842 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 748727004843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727004844 catalytic residue [active] 748727004845 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 748727004846 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 748727004847 substrate binding site [chemical binding]; other site 748727004848 active site 748727004849 catalytic residues [active] 748727004850 heterodimer interface [polypeptide binding]; other site 748727004851 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 748727004852 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 748727004853 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 748727004854 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 748727004855 catalytic Zn binding site [ion binding]; other site 748727004856 NAD binding site [chemical binding]; other site 748727004857 structural Zn binding site [ion binding]; other site 748727004858 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 748727004859 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727004860 active site 748727004861 FMN binding site [chemical binding]; other site 748727004862 substrate binding site [chemical binding]; other site 748727004863 putative catalytic residue [active] 748727004864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727004865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727004866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727004867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727004868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727004869 dimerization interface [polypeptide binding]; other site 748727004870 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 748727004871 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 748727004872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727004873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727004874 DNA binding residues [nucleotide binding] 748727004875 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727004876 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727004877 CAAX protease self-immunity; Region: Abi; pfam02517 748727004878 Peptidase family S41; Region: Peptidase_S41; pfam03572 748727004879 Active site serine [active] 748727004880 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727004881 MarR family; Region: MarR_2; pfam12802 748727004882 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727004883 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727004884 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748727004885 active site 748727004886 catalytic residues [active] 748727004887 metal binding site [ion binding]; metal-binding site 748727004888 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727004889 metal binding site 2 [ion binding]; metal-binding site 748727004890 putative DNA binding helix; other site 748727004891 metal binding site 1 [ion binding]; metal-binding site 748727004892 dimer interface [polypeptide binding]; other site 748727004893 structural Zn2+ binding site [ion binding]; other site 748727004894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727004895 dimer interface [polypeptide binding]; other site 748727004896 putative CheW interface [polypeptide binding]; other site 748727004897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727004898 MarR family; Region: MarR; pfam01047 748727004899 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727004900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727004901 putative Zn2+ binding site [ion binding]; other site 748727004902 putative DNA binding site [nucleotide binding]; other site 748727004903 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 748727004904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727004905 putative substrate translocation pore; other site 748727004906 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 748727004907 ATP binding site [chemical binding]; other site 748727004908 Mg2+ binding site [ion binding]; other site 748727004909 G-X-G motif; other site 748727004910 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727004911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727004912 active site 748727004913 phosphorylation site [posttranslational modification] 748727004914 intermolecular recognition site; other site 748727004915 dimerization interface [polypeptide binding]; other site 748727004916 LytTr DNA-binding domain; Region: LytTR; pfam04397 748727004917 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 748727004918 Predicted membrane protein [Function unknown]; Region: COG2323 748727004919 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 748727004920 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 748727004921 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 748727004922 active site 748727004923 inner membrane transporter YjeM; Provisional; Region: PRK15238 748727004924 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 748727004925 Spore germination protein; Region: Spore_permease; cl17796 748727004926 Spore germination protein; Region: Spore_permease; cl17796 748727004927 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727004928 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727004929 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727004930 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 748727004931 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748727004932 putative catalytic cysteine [active] 748727004933 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 748727004934 putative active site [active] 748727004935 metal binding site [ion binding]; metal-binding site 748727004936 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 748727004937 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748727004938 putative catalytic cysteine [active] 748727004939 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 748727004940 putative active site [active] 748727004941 metal binding site [ion binding]; metal-binding site 748727004942 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 748727004943 Part of AAA domain; Region: AAA_19; pfam13245 748727004944 Family description; Region: UvrD_C_2; pfam13538 748727004945 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 748727004946 active site 748727004947 catalytic residues [active] 748727004948 DNA binding site [nucleotide binding] 748727004949 Int/Topo IB signature motif; other site 748727004950 Helix-turn-helix domain; Region: HTH_36; pfam13730 748727004951 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 748727004952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004953 non-specific DNA binding site [nucleotide binding]; other site 748727004954 salt bridge; other site 748727004955 sequence-specific DNA binding site [nucleotide binding]; other site 748727004956 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 748727004957 Mg binding site [ion binding]; other site 748727004958 nucleotide binding site [chemical binding]; other site 748727004959 putative protofilament interface [polypeptide binding]; other site 748727004960 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 748727004961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727004962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727004963 non-specific DNA binding site [nucleotide binding]; other site 748727004964 salt bridge; other site 748727004965 sequence-specific DNA binding site [nucleotide binding]; other site 748727004966 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 748727004967 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748727004968 NlpC/P60 family; Region: NLPC_P60; pfam00877 748727004969 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 748727004970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748727004971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748727004972 catalytic residue [active] 748727004973 large terminase protein; Provisional; Region: 17; PHA02533 748727004974 Terminase-like family; Region: Terminase_6; pfam03237 748727004975 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 748727004976 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 748727004977 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 748727004978 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727004979 SdpI/YhfL protein family; Region: SdpI; pfam13630 748727004980 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 748727004981 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 748727004982 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748727004983 active site 748727004984 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 748727004985 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727004986 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727004987 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727004988 Rubrerythrin [Energy production and conversion]; Region: COG1592 748727004989 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 748727004990 binuclear metal center [ion binding]; other site 748727004991 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 748727004992 iron binding site [ion binding]; other site 748727004993 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 748727004994 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 748727004995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727004996 motif II; other site 748727004997 Predicted membrane protein [Function unknown]; Region: COG2323 748727004998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748727004999 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748727005000 active site 748727005001 catalytic tetrad [active] 748727005002 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 748727005003 polypeptide substrate binding site [polypeptide binding]; other site 748727005004 active site 748727005005 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727005006 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 748727005007 putative ligand binding residues [chemical binding]; other site 748727005008 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748727005009 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 748727005010 dimer interface [polypeptide binding]; other site 748727005011 putative functional site; other site 748727005012 putative MPT binding site; other site 748727005013 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727005014 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 748727005015 putative metal binding site [ion binding]; other site 748727005016 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 748727005017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748727005018 dimer interface [polypeptide binding]; other site 748727005019 putative PBP binding regions; other site 748727005020 ABC-ATPase subunit interface; other site 748727005021 NTPase; Region: NTPase_1; cl17478 748727005022 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727005023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748727005024 intersubunit interface [polypeptide binding]; other site 748727005025 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748727005026 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748727005027 Walker A/P-loop; other site 748727005028 ATP binding site [chemical binding]; other site 748727005029 Q-loop/lid; other site 748727005030 ABC transporter signature motif; other site 748727005031 Walker B; other site 748727005032 D-loop; other site 748727005033 H-loop/switch region; other site 748727005034 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 748727005035 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727005036 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 748727005037 putative ligand binding residues [chemical binding]; other site 748727005038 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748727005039 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748727005040 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727005041 intersubunit interface [polypeptide binding]; other site 748727005042 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 748727005043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005044 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 748727005045 Walker A/P-loop; other site 748727005046 ATP binding site [chemical binding]; other site 748727005047 Q-loop/lid; other site 748727005048 ABC transporter signature motif; other site 748727005049 Walker B; other site 748727005050 D-loop; other site 748727005051 H-loop/switch region; other site 748727005052 Uncharacterized conserved protein [Function unknown]; Region: COG2014 748727005053 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 748727005054 Domain of unknown function (DUF364); Region: DUF364; pfam04016 748727005055 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 748727005056 Domain of unknown function (DUF364); Region: DUF364; pfam04016 748727005057 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 748727005058 putative ligand binding residues [chemical binding]; other site 748727005059 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 748727005060 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748727005061 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727005062 DNA binding residues [nucleotide binding] 748727005063 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 748727005064 4Fe-4S binding domain; Region: Fer4; pfam00037 748727005065 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748727005066 4Fe-4S binding domain; Region: Fer4; pfam00037 748727005067 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727005068 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 748727005069 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 748727005070 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 748727005071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727005072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005073 active site 748727005074 phosphorylation site [posttranslational modification] 748727005075 intermolecular recognition site; other site 748727005076 dimerization interface [polypeptide binding]; other site 748727005077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727005078 DNA binding site [nucleotide binding] 748727005079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727005081 dimerization interface [polypeptide binding]; other site 748727005082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727005083 dimer interface [polypeptide binding]; other site 748727005084 phosphorylation site [posttranslational modification] 748727005085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005086 ATP binding site [chemical binding]; other site 748727005087 Mg2+ binding site [ion binding]; other site 748727005088 G-X-G motif; other site 748727005089 cell division protein FtsA; Region: ftsA; TIGR01174 748727005090 Cell division protein FtsA; Region: FtsA; smart00842 748727005091 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727005092 nucleotide binding site [chemical binding]; other site 748727005093 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748727005094 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 748727005095 metal binding site [ion binding]; metal-binding site 748727005096 dimer interface [polypeptide binding]; other site 748727005097 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748727005098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727005099 RNA binding surface [nucleotide binding]; other site 748727005100 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748727005101 active site 748727005102 stage V sporulation protein B; Region: spore_V_B; TIGR02900 748727005103 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748727005104 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 748727005105 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 748727005106 active site 748727005107 dimer interface [polypeptide binding]; other site 748727005108 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 748727005109 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 748727005110 active site 748727005111 FMN binding site [chemical binding]; other site 748727005112 substrate binding site [chemical binding]; other site 748727005113 3Fe-4S cluster binding site [ion binding]; other site 748727005114 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 748727005115 domain interface; other site 748727005116 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 748727005117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727005118 dipeptidase PepV; Reviewed; Region: PRK07318 748727005119 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 748727005120 active site 748727005121 metal binding site [ion binding]; metal-binding site 748727005122 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 748727005123 Uncharacterized conserved protein [Function unknown]; Region: COG1434 748727005124 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 748727005125 putative active site [active] 748727005126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727005127 MarR family; Region: MarR; pfam01047 748727005128 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 748727005129 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 748727005130 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 748727005131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 748727005132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748727005133 DNA binding residues [nucleotide binding] 748727005134 dimerization interface [polypeptide binding]; other site 748727005135 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727005136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727005137 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727005138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727005139 MarR family; Region: MarR_2; pfam12802 748727005140 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 748727005141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005142 putative CheW interface [polypeptide binding]; other site 748727005143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748727005144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748727005145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748727005146 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 748727005147 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 748727005148 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 748727005149 B3/4 domain; Region: B3_4; pfam03483 748727005150 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727005151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727005152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727005153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727005154 dimerization interface [polypeptide binding]; other site 748727005155 Chromate transporter; Region: Chromate_transp; pfam02417 748727005156 Chromate transporter; Region: Chromate_transp; pfam02417 748727005157 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 748727005158 DJ-1 family protein; Region: not_thiJ; TIGR01383 748727005159 conserved cys residue [active] 748727005160 flavodoxin; Provisional; Region: PRK06242 748727005161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727005162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727005163 non-specific DNA binding site [nucleotide binding]; other site 748727005164 salt bridge; other site 748727005165 sequence-specific DNA binding site [nucleotide binding]; other site 748727005166 Cache domain; Region: Cache_1; pfam02743 748727005167 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727005168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727005169 metal binding site [ion binding]; metal-binding site 748727005170 active site 748727005171 I-site; other site 748727005172 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 748727005173 nudix motif; other site 748727005174 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 748727005175 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727005176 MarR family; Region: MarR_2; pfam12802 748727005177 MarR family; Region: MarR_2; cl17246 748727005178 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 748727005179 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 748727005180 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 748727005181 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 748727005182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727005183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727005184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727005185 dimerization interface [polypeptide binding]; other site 748727005186 asparagine synthetase B; Provisional; Region: asnB; PRK09431 748727005187 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 748727005188 dimer interface [polypeptide binding]; other site 748727005189 active site 748727005190 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748727005191 Ligand Binding Site [chemical binding]; other site 748727005192 Molecular Tunnel; other site 748727005193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727005194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727005195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727005196 dimerization interface [polypeptide binding]; other site 748727005197 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 748727005198 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727005199 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748727005200 hypothetical protein; Provisional; Region: PRK10281 748727005201 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748727005202 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 748727005203 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748727005204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727005205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748727005206 active site 748727005207 motif I; other site 748727005208 motif II; other site 748727005209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727005210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748727005211 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748727005212 active site 748727005213 catalytic tetrad [active] 748727005214 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748727005215 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 748727005216 Peptidase family M28; Region: Peptidase_M28; pfam04389 748727005217 metal binding site [ion binding]; metal-binding site 748727005218 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748727005219 active site 748727005220 catalytic residues [active] 748727005221 metal binding site [ion binding]; metal-binding site 748727005222 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727005223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727005224 DNA-binding site [nucleotide binding]; DNA binding site 748727005225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727005226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727005227 homodimer interface [polypeptide binding]; other site 748727005228 catalytic residue [active] 748727005229 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 748727005230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005231 active site 748727005232 phosphorylation site [posttranslational modification] 748727005233 intermolecular recognition site; other site 748727005234 dimerization interface [polypeptide binding]; other site 748727005235 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 748727005236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005237 active site 748727005238 phosphorylation site [posttranslational modification] 748727005239 intermolecular recognition site; other site 748727005240 dimerization interface [polypeptide binding]; other site 748727005241 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 748727005242 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 748727005243 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 748727005244 DNA binding site [nucleotide binding] 748727005245 active site 748727005246 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 748727005247 A new structural DNA glycosylase; Region: AlkD_like; cd06561 748727005248 active site 748727005249 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727005250 putative transport protein YifK; Provisional; Region: PRK10746 748727005251 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 748727005252 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 748727005253 ACS interaction site; other site 748727005254 CODH interaction site; other site 748727005255 cubane metal cluster (B-cluster) [ion binding]; other site 748727005256 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 748727005257 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 748727005258 G1 box; other site 748727005259 GTP/Mg2+ binding site [chemical binding]; other site 748727005260 G2 box; other site 748727005261 Switch I region; other site 748727005262 G3 box; other site 748727005263 Switch II region; other site 748727005264 G4 box; other site 748727005265 G5 box; other site 748727005266 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 748727005267 putative hexamer interface [polypeptide binding]; other site 748727005268 putative hexagonal pore; other site 748727005269 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 748727005270 XdhC Rossmann domain; Region: XdhC_C; pfam13478 748727005271 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 748727005272 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 748727005273 putative MPT binding site; other site 748727005274 FIST N domain; Region: FIST; pfam08495 748727005275 FIST C domain; Region: FIST_C; pfam10442 748727005276 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727005277 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727005278 metal binding site [ion binding]; metal-binding site 748727005279 active site 748727005280 I-site; other site 748727005281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727005282 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 748727005283 DNA binding residues [nucleotide binding] 748727005284 drug binding residues [chemical binding]; other site 748727005285 dimer interface [polypeptide binding]; other site 748727005286 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 748727005287 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 748727005288 4Fe-4S binding domain; Region: Fer4; pfam00037 748727005289 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 748727005290 Nitroreductase family; Region: Nitroreductase; pfam00881 748727005291 FMN binding site [chemical binding]; other site 748727005292 dimer interface [polypeptide binding]; other site 748727005293 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727005294 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748727005295 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 748727005296 Bacterial SH3 domain; Region: SH3_3; pfam08239 748727005297 Bacterial SH3 domain; Region: SH3_3; pfam08239 748727005298 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005299 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005300 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748727005302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748727005303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005304 dimer interface [polypeptide binding]; other site 748727005305 putative CheW interface [polypeptide binding]; other site 748727005306 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 748727005307 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 748727005308 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 748727005309 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748727005310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727005311 DNA-binding site [nucleotide binding]; DNA binding site 748727005312 TrkA-C domain; Region: TrkA_C; pfam02080 748727005313 Yip1 domain; Region: Yip1; pfam04893 748727005314 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748727005315 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727005316 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727005317 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727005318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727005319 Walker A/P-loop; other site 748727005320 ATP binding site [chemical binding]; other site 748727005321 Q-loop/lid; other site 748727005322 ABC transporter signature motif; other site 748727005323 Walker B; other site 748727005324 D-loop; other site 748727005325 H-loop/switch region; other site 748727005326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727005327 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727005328 FtsX-like permease family; Region: FtsX; pfam02687 748727005329 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748727005330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727005331 DNA binding residues [nucleotide binding] 748727005332 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748727005333 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 748727005334 active site 748727005335 catalytic motif [active] 748727005336 Zn binding site [ion binding]; other site 748727005337 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 748727005338 intersubunit interface [polypeptide binding]; other site 748727005339 active site 748727005340 catalytic residue [active] 748727005341 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 748727005342 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 748727005343 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 748727005344 phosphopentomutase; Provisional; Region: PRK05362 748727005345 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 748727005346 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 748727005347 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 748727005348 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 748727005349 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 748727005350 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 748727005351 TIGR01210 family protein; Region: TIGR01210 748727005352 QueT transporter; Region: QueT; pfam06177 748727005353 xylose isomerase; Provisional; Region: PRK05474 748727005354 xylose isomerase; Region: xylose_isom_A; TIGR02630 748727005355 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 748727005356 N- and C-terminal domain interface [polypeptide binding]; other site 748727005357 D-xylulose kinase; Region: XylB; TIGR01312 748727005358 active site 748727005359 MgATP binding site [chemical binding]; other site 748727005360 catalytic site [active] 748727005361 metal binding site [ion binding]; metal-binding site 748727005362 xylulose binding site [chemical binding]; other site 748727005363 homodimer interface [polypeptide binding]; other site 748727005364 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 748727005365 active site 748727005366 catalytic residues [active] 748727005367 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 748727005368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727005369 putative substrate translocation pore; other site 748727005370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727005371 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 748727005372 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 748727005373 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748727005374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727005375 nucleotide binding site [chemical binding]; other site 748727005376 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 748727005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727005378 dimer interface [polypeptide binding]; other site 748727005379 conserved gate region; other site 748727005380 putative PBP binding loops; other site 748727005381 ABC-ATPase subunit interface; other site 748727005382 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 748727005383 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 748727005384 Walker A/P-loop; other site 748727005385 ATP binding site [chemical binding]; other site 748727005386 Q-loop/lid; other site 748727005387 ABC transporter signature motif; other site 748727005388 Walker B; other site 748727005389 D-loop; other site 748727005390 H-loop/switch region; other site 748727005391 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 748727005392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727005393 substrate binding pocket [chemical binding]; other site 748727005394 membrane-bound complex binding site; other site 748727005395 hinge residues; other site 748727005396 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 748727005397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727005398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005399 Walker A/P-loop; other site 748727005400 ATP binding site [chemical binding]; other site 748727005401 Q-loop/lid; other site 748727005402 ABC transporter signature motif; other site 748727005403 Walker B; other site 748727005404 D-loop; other site 748727005405 H-loop/switch region; other site 748727005406 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727005407 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 748727005408 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 748727005409 active site 748727005410 catalytic triad [active] 748727005411 oxyanion hole [active] 748727005412 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 748727005413 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 748727005414 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727005415 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727005416 Spore germination protein; Region: Spore_permease; cl17796 748727005417 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727005418 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727005419 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 748727005420 putative active site [active] 748727005421 metal binding site [ion binding]; metal-binding site 748727005422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727005423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727005424 non-specific DNA binding site [nucleotide binding]; other site 748727005425 salt bridge; other site 748727005426 sequence-specific DNA binding site [nucleotide binding]; other site 748727005427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005428 dimer interface [polypeptide binding]; other site 748727005429 putative CheW interface [polypeptide binding]; other site 748727005430 Glucose inhibited division protein A; Region: GIDA; pfam01134 748727005431 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 748727005432 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 748727005433 catalytic residues [active] 748727005434 catalytic nucleophile [active] 748727005435 Presynaptic Site I dimer interface [polypeptide binding]; other site 748727005436 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 748727005437 Synaptic Flat tetramer interface [polypeptide binding]; other site 748727005438 Synaptic Site I dimer interface [polypeptide binding]; other site 748727005439 DNA binding site [nucleotide binding] 748727005440 Recombinase; Region: Recombinase; pfam07508 748727005441 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 748727005442 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 748727005443 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 748727005444 Glucose inhibited division protein A; Region: GIDA; pfam01134 748727005445 hypothetical protein; Provisional; Region: PRK05802 748727005446 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 748727005447 FAD binding pocket [chemical binding]; other site 748727005448 FAD binding motif [chemical binding]; other site 748727005449 phosphate binding motif [ion binding]; other site 748727005450 beta-alpha-beta structure motif; other site 748727005451 NAD binding pocket [chemical binding]; other site 748727005452 Iron coordination center [ion binding]; other site 748727005453 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727005454 EamA-like transporter family; Region: EamA; pfam00892 748727005455 EamA-like transporter family; Region: EamA; pfam00892 748727005456 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005457 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 748727005458 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005459 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005460 PAS domain S-box; Region: sensory_box; TIGR00229 748727005461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727005462 putative active site [active] 748727005463 heme pocket [chemical binding]; other site 748727005464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727005465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727005466 metal binding site [ion binding]; metal-binding site 748727005467 active site 748727005468 I-site; other site 748727005469 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727005470 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 748727005471 dimanganese center [ion binding]; other site 748727005472 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 748727005473 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 748727005474 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 748727005475 catalytic residues [active] 748727005476 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005477 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005478 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005479 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 748727005480 Cache domain; Region: Cache_1; pfam02743 748727005481 HAMP domain; Region: HAMP; pfam00672 748727005482 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727005484 dimer interface [polypeptide binding]; other site 748727005485 putative CheW interface [polypeptide binding]; other site 748727005486 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748727005487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727005488 FeS/SAM binding site; other site 748727005489 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727005490 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 748727005491 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 748727005492 GH3 auxin-responsive promoter; Region: GH3; pfam03321 748727005493 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005494 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005495 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727005496 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 748727005497 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 748727005498 active site 748727005499 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 748727005500 Response regulator receiver domain; Region: Response_reg; pfam00072 748727005501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005502 active site 748727005503 phosphorylation site [posttranslational modification] 748727005504 intermolecular recognition site; other site 748727005505 dimerization interface [polypeptide binding]; other site 748727005506 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 748727005507 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 748727005508 CheC-like family; Region: CheC; pfam04509 748727005509 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 748727005510 Cache domain; Region: Cache_1; pfam02743 748727005511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 748727005512 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005513 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727005514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005515 dimer interface [polypeptide binding]; other site 748727005516 putative CheW interface [polypeptide binding]; other site 748727005517 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727005518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727005519 putative DNA binding site [nucleotide binding]; other site 748727005520 putative Zn2+ binding site [ion binding]; other site 748727005521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727005522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727005523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005524 Walker A/P-loop; other site 748727005525 ATP binding site [chemical binding]; other site 748727005526 Q-loop/lid; other site 748727005527 ABC transporter signature motif; other site 748727005528 Walker B; other site 748727005529 D-loop; other site 748727005530 H-loop/switch region; other site 748727005531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727005532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727005533 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748727005534 Walker A/P-loop; other site 748727005535 ATP binding site [chemical binding]; other site 748727005536 Q-loop/lid; other site 748727005537 ABC transporter signature motif; other site 748727005538 Walker B; other site 748727005539 D-loop; other site 748727005540 H-loop/switch region; other site 748727005541 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727005542 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 748727005543 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727005544 VanW like protein; Region: VanW; pfam04294 748727005545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748727005546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727005547 S-adenosylmethionine binding site [chemical binding]; other site 748727005548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748727005549 active site 748727005550 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 748727005551 putative metal binding site; other site 748727005552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727005553 binding surface 748727005554 TPR motif; other site 748727005555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005556 Walker A/P-loop; other site 748727005557 ATP binding site [chemical binding]; other site 748727005558 Q-loop/lid; other site 748727005559 VanW like protein; Region: VanW; pfam04294 748727005560 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748727005561 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727005562 ABC transporter; Region: ABC_tran_2; pfam12848 748727005563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727005564 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 748727005565 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 748727005566 Predicted membrane protein [Function unknown]; Region: COG4684 748727005567 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748727005568 oligoendopeptidase F; Region: pepF; TIGR00181 748727005569 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 748727005570 active site 748727005571 Zn binding site [ion binding]; other site 748727005572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727005573 ATP binding site [chemical binding]; other site 748727005574 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 748727005575 putative Mg++ binding site [ion binding]; other site 748727005576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727005577 nucleotide binding region [chemical binding]; other site 748727005578 ATP-binding site [chemical binding]; other site 748727005579 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 748727005580 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 748727005581 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727005582 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 748727005583 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727005584 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727005585 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 748727005586 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727005587 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748727005588 B12 binding site [chemical binding]; other site 748727005589 cobalt ligand [ion binding]; other site 748727005590 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727005591 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 748727005592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727005593 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 748727005594 catalytic loop [active] 748727005595 iron binding site [ion binding]; other site 748727005596 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727005597 nucleotide binding site [chemical binding]; other site 748727005598 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 748727005599 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748727005600 active site 748727005601 catalytic site [active] 748727005602 substrate binding site [chemical binding]; other site 748727005603 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748727005604 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748727005605 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748727005606 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748727005607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748727005608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748727005609 Helix-turn-helix domain; Region: HTH_28; pfam13518 748727005610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748727005611 Helix-turn-helix domain; Region: HTH_28; pfam13518 748727005612 Winged helix-turn helix; Region: HTH_29; pfam13551 748727005613 Protein of unknown function (DUF972); Region: DUF972; pfam06156 748727005614 HTH-like domain; Region: HTH_21; pfam13276 748727005615 Integrase core domain; Region: rve; pfam00665 748727005616 Integrase core domain; Region: rve_2; pfam13333 748727005617 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 748727005618 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 748727005619 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 748727005620 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 748727005621 Na binding site [ion binding]; other site 748727005622 cytosine deaminase; Provisional; Region: PRK09230 748727005623 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 748727005624 active site 748727005625 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 748727005626 TOBE domain; Region: TOBE; cl01440 748727005627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727005628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 748727005629 OsmC-like protein; Region: OsmC; pfam02566 748727005630 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 748727005631 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748727005632 putative ligand binding site [chemical binding]; other site 748727005633 putative NAD binding site [chemical binding]; other site 748727005634 catalytic site [active] 748727005635 peptidase T; Region: peptidase-T; TIGR01882 748727005636 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 748727005637 metal binding site [ion binding]; metal-binding site 748727005638 dimer interface [polypeptide binding]; other site 748727005639 AAA ATPase domain; Region: AAA_16; pfam13191 748727005640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748727005641 DNA binding residues [nucleotide binding] 748727005642 dimerization interface [polypeptide binding]; other site 748727005643 peptidase T; Region: peptidase-T; TIGR01882 748727005644 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 748727005645 metal binding site [ion binding]; metal-binding site 748727005646 dimer interface [polypeptide binding]; other site 748727005647 inner membrane transporter YjeM; Provisional; Region: PRK15238 748727005648 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 748727005649 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 748727005650 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 748727005651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727005652 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727005653 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727005654 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727005655 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727005656 Predicted permeases [General function prediction only]; Region: COG0679 748727005657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727005658 non-specific DNA binding site [nucleotide binding]; other site 748727005659 salt bridge; other site 748727005660 sequence-specific DNA binding site [nucleotide binding]; other site 748727005661 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727005662 MarR family; Region: MarR; pfam01047 748727005663 MarR family; Region: MarR_2; cl17246 748727005664 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727005665 metal binding site 2 [ion binding]; metal-binding site 748727005666 putative DNA binding helix; other site 748727005667 metal binding site 1 [ion binding]; metal-binding site 748727005668 dimer interface [polypeptide binding]; other site 748727005669 structural Zn2+ binding site [ion binding]; other site 748727005670 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 748727005671 EamA-like transporter family; Region: EamA; pfam00892 748727005672 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 748727005673 EamA-like transporter family; Region: EamA; pfam00892 748727005674 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 748727005675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727005676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005677 active site 748727005678 phosphorylation site [posttranslational modification] 748727005679 intermolecular recognition site; other site 748727005680 dimerization interface [polypeptide binding]; other site 748727005681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727005682 DNA binding site [nucleotide binding] 748727005683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005684 HAMP domain; Region: HAMP; pfam00672 748727005685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727005686 dimer interface [polypeptide binding]; other site 748727005687 phosphorylation site [posttranslational modification] 748727005688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005689 ATP binding site [chemical binding]; other site 748727005690 Mg2+ binding site [ion binding]; other site 748727005691 G-X-G motif; other site 748727005692 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 748727005693 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 748727005694 Rubredoxin; Region: Rubredoxin; pfam00301 748727005695 iron binding site [ion binding]; other site 748727005696 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 748727005697 Ferritin-like domain; Region: Ferritin; pfam00210 748727005698 ferroxidase diiron center [ion binding]; other site 748727005699 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748727005700 DNA-binding site [nucleotide binding]; DNA binding site 748727005701 RNA-binding motif; other site 748727005702 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 748727005703 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 748727005704 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 748727005705 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 748727005706 putative NADH binding site [chemical binding]; other site 748727005707 putative active site [active] 748727005708 nudix motif; other site 748727005709 putative metal binding site [ion binding]; other site 748727005710 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 748727005711 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 748727005712 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727005713 NAD binding site [chemical binding]; other site 748727005714 catalytic Zn binding site [ion binding]; other site 748727005715 structural Zn binding site [ion binding]; other site 748727005716 Coat F domain; Region: Coat_F; cl17715 748727005717 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 748727005718 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727005719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748727005720 DNA-binding site [nucleotide binding]; DNA binding site 748727005721 RNA-binding motif; other site 748727005722 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 748727005723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727005724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727005725 homodimer interface [polypeptide binding]; other site 748727005726 catalytic residue [active] 748727005727 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727005728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727005729 DNA-binding site [nucleotide binding]; DNA binding site 748727005730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727005731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727005732 homodimer interface [polypeptide binding]; other site 748727005733 catalytic residue [active] 748727005734 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 748727005735 Peptidase family M50; Region: Peptidase_M50; pfam02163 748727005736 active site 748727005737 putative substrate binding region [chemical binding]; other site 748727005738 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 748727005739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005740 HAMP domain; Region: HAMP; pfam00672 748727005741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727005742 dimer interface [polypeptide binding]; other site 748727005743 phosphorylation site [posttranslational modification] 748727005744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005745 ATP binding site [chemical binding]; other site 748727005746 Mg2+ binding site [ion binding]; other site 748727005747 G-X-G motif; other site 748727005748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727005749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005750 active site 748727005751 phosphorylation site [posttranslational modification] 748727005752 intermolecular recognition site; other site 748727005753 dimerization interface [polypeptide binding]; other site 748727005754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727005755 DNA binding site [nucleotide binding] 748727005756 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727005757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005758 Walker A/P-loop; other site 748727005759 ATP binding site [chemical binding]; other site 748727005760 Q-loop/lid; other site 748727005761 ABC transporter signature motif; other site 748727005762 Walker B; other site 748727005763 D-loop; other site 748727005764 H-loop/switch region; other site 748727005765 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727005766 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 748727005767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727005768 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 748727005769 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 748727005770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727005771 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 748727005772 putative ADP-binding pocket [chemical binding]; other site 748727005773 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 748727005774 dinuclear metal binding motif [ion binding]; other site 748727005775 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 748727005776 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 748727005777 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 748727005778 ligand binding site [chemical binding]; other site 748727005779 flagellar motor protein MotA; Validated; Region: PRK08124 748727005780 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 748727005781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727005782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727005783 putative substrate translocation pore; other site 748727005784 Uncharacterized conserved protein [Function unknown]; Region: COG3287 748727005785 FIST N domain; Region: FIST; pfam08495 748727005786 FIST C domain; Region: FIST_C; pfam10442 748727005787 Response regulator receiver domain; Region: Response_reg; pfam00072 748727005788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005789 active site 748727005790 phosphorylation site [posttranslational modification] 748727005791 intermolecular recognition site; other site 748727005792 dimerization interface [polypeptide binding]; other site 748727005793 PAS domain S-box; Region: sensory_box; TIGR00229 748727005794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727005796 dimer interface [polypeptide binding]; other site 748727005797 phosphorylation site [posttranslational modification] 748727005798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005799 ATP binding site [chemical binding]; other site 748727005800 Mg2+ binding site [ion binding]; other site 748727005801 G-X-G motif; other site 748727005802 heat shock protein 90; Provisional; Region: PRK05218 748727005803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005804 ATP binding site [chemical binding]; other site 748727005805 Mg2+ binding site [ion binding]; other site 748727005806 G-X-G motif; other site 748727005807 Amino acid permease; Region: AA_permease_2; pfam13520 748727005808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727005809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727005810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727005811 dimerization interface [polypeptide binding]; other site 748727005812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727005813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727005814 active site 748727005815 phosphorylation site [posttranslational modification] 748727005816 intermolecular recognition site; other site 748727005817 dimerization interface [polypeptide binding]; other site 748727005818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727005819 DNA binding site [nucleotide binding] 748727005820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727005822 dimerization interface [polypeptide binding]; other site 748727005823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727005824 dimer interface [polypeptide binding]; other site 748727005825 phosphorylation site [posttranslational modification] 748727005826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005827 ATP binding site [chemical binding]; other site 748727005828 Mg2+ binding site [ion binding]; other site 748727005829 G-X-G motif; other site 748727005830 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 748727005831 putative deacylase active site [active] 748727005832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727005833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727005834 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 748727005835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 748727005836 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 748727005837 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748727005838 Interdomain contacts; other site 748727005839 Cytokine receptor motif; other site 748727005840 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 748727005841 active site 748727005842 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 748727005843 Transcriptional regulators [Transcription]; Region: GntR; COG1802 748727005844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727005845 DNA-binding site [nucleotide binding]; DNA binding site 748727005846 FCD domain; Region: FCD; pfam07729 748727005847 LemA family; Region: LemA; cl00742 748727005848 Repair protein; Region: Repair_PSII; pfam04536 748727005849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727005850 DNA binding site [nucleotide binding] 748727005851 active site 748727005852 Int/Topo IB signature motif; other site 748727005853 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727005854 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727005855 DNA binding residues [nucleotide binding] 748727005856 putative dimer interface [polypeptide binding]; other site 748727005857 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 748727005858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 748727005859 NADP binding site [chemical binding]; other site 748727005860 putative substrate binding site [chemical binding]; other site 748727005861 active site 748727005862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727005863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 748727005864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727005865 ATP binding site [chemical binding]; other site 748727005866 Mg2+ binding site [ion binding]; other site 748727005867 G-X-G motif; other site 748727005868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 748727005869 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 748727005870 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 748727005871 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748727005872 synthetase active site [active] 748727005873 NTP binding site [chemical binding]; other site 748727005874 metal binding site [ion binding]; metal-binding site 748727005875 Cache domain; Region: Cache_1; pfam02743 748727005876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727005877 dimerization interface [polypeptide binding]; other site 748727005878 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727005879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727005880 dimer interface [polypeptide binding]; other site 748727005881 putative CheW interface [polypeptide binding]; other site 748727005882 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 748727005883 short chain dehydrogenase; Provisional; Region: PRK06701 748727005884 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 748727005885 NAD binding site [chemical binding]; other site 748727005886 metal binding site [ion binding]; metal-binding site 748727005887 active site 748727005888 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 748727005889 FMN binding site [chemical binding]; other site 748727005890 dimer interface [polypeptide binding]; other site 748727005891 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 748727005892 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 748727005893 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 748727005894 [4Fe-4S] binding site [ion binding]; other site 748727005895 molybdopterin cofactor binding site; other site 748727005896 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 748727005897 molybdopterin cofactor binding site; other site 748727005898 ThiS family; Region: ThiS; pfam02597 748727005899 charged pocket; other site 748727005900 hydrophobic patch; other site 748727005901 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 748727005902 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 748727005903 ATP binding site [chemical binding]; other site 748727005904 substrate interface [chemical binding]; other site 748727005905 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748727005906 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748727005907 Walker A/P-loop; other site 748727005908 ATP binding site [chemical binding]; other site 748727005909 Q-loop/lid; other site 748727005910 ABC transporter signature motif; other site 748727005911 Walker B; other site 748727005912 D-loop; other site 748727005913 H-loop/switch region; other site 748727005914 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748727005915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748727005916 ABC-ATPase subunit interface; other site 748727005917 dimer interface [polypeptide binding]; other site 748727005918 putative PBP binding regions; other site 748727005919 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 748727005920 putative ligand binding residues [chemical binding]; other site 748727005921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 748727005922 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748727005923 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 748727005924 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 748727005925 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 748727005926 PAS domain; Region: PAS; smart00091 748727005927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727005928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 748727005929 Walker A motif; other site 748727005930 ATP binding site [chemical binding]; other site 748727005931 Walker B motif; other site 748727005932 arginine finger; other site 748727005933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727005934 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 748727005935 PAS domain; Region: PAS; smart00091 748727005936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727005937 Walker A motif; other site 748727005938 ATP binding site [chemical binding]; other site 748727005939 Walker B motif; other site 748727005940 arginine finger; other site 748727005941 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727005942 PBP superfamily domain; Region: PBP_like_2; pfam12849 748727005943 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 748727005944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727005945 dimer interface [polypeptide binding]; other site 748727005946 conserved gate region; other site 748727005947 putative PBP binding loops; other site 748727005948 ABC-ATPase subunit interface; other site 748727005949 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748727005950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727005951 Walker A/P-loop; other site 748727005952 ATP binding site [chemical binding]; other site 748727005953 Q-loop/lid; other site 748727005954 ABC transporter signature motif; other site 748727005955 Walker B; other site 748727005956 D-loop; other site 748727005957 H-loop/switch region; other site 748727005958 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 748727005959 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748727005960 dimer interface [polypeptide binding]; other site 748727005961 putative functional site; other site 748727005962 putative MPT binding site; other site 748727005963 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 748727005964 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748727005965 dimer interface [polypeptide binding]; other site 748727005966 putative functional site; other site 748727005967 putative MPT binding site; other site 748727005968 PBP superfamily domain; Region: PBP_like; pfam12727 748727005969 MOSC domain; Region: MOSC; pfam03473 748727005970 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 748727005971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727005972 Walker A motif; other site 748727005973 ATP binding site [chemical binding]; other site 748727005974 Walker B motif; other site 748727005975 arginine finger; other site 748727005976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727005977 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 748727005978 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 748727005979 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 748727005980 ThiS family; Region: ThiS; pfam02597 748727005981 charged pocket; other site 748727005982 hydrophobic patch; other site 748727005983 hypothetical protein; Provisional; Region: PRK08328 748727005984 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 748727005985 ATP binding site [chemical binding]; other site 748727005986 substrate interface [chemical binding]; other site 748727005987 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 748727005988 PAS domain; Region: PAS; smart00091 748727005989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727005990 Walker A motif; other site 748727005991 ATP binding site [chemical binding]; other site 748727005992 Walker B motif; other site 748727005993 arginine finger; other site 748727005994 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727005995 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727005996 Predicted membrane protein [Function unknown]; Region: COG2510 748727005997 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727005998 Predicted membrane protein [Function unknown]; Region: COG2510 748727005999 endonuclease IV; Provisional; Region: PRK01060 748727006000 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 748727006001 AP (apurinic/apyrimidinic) site pocket; other site 748727006002 DNA interaction; other site 748727006003 Metal-binding active site; metal-binding site 748727006004 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727006005 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727006006 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727006007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727006008 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 748727006009 4Fe-4S binding domain; Region: Fer4; pfam00037 748727006010 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727006011 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 748727006012 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 748727006013 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 748727006014 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727006015 active site 748727006016 metal binding site [ion binding]; metal-binding site 748727006017 DNA binding site [nucleotide binding] 748727006018 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 748727006019 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 748727006020 AAA domain; Region: AAA_23; pfam13476 748727006021 Walker A/P-loop; other site 748727006022 ATP binding site [chemical binding]; other site 748727006023 Q-loop/lid; other site 748727006024 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 748727006025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727006026 ABC transporter signature motif; other site 748727006027 Walker B; other site 748727006028 D-loop; other site 748727006029 H-loop/switch region; other site 748727006030 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 748727006031 Ligand binding site [chemical binding]; other site 748727006032 Electron transfer flavoprotein domain; Region: ETF; pfam01012 748727006033 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 748727006034 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 748727006035 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 748727006036 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 748727006037 FAD binding domain; Region: FAD_binding_4; pfam01565 748727006038 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 748727006039 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 748727006040 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 748727006041 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748727006042 4Fe-4S binding domain; Region: Fer4; pfam00037 748727006043 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727006044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727006045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727006046 dimer interface [polypeptide binding]; other site 748727006047 putative CheW interface [polypeptide binding]; other site 748727006048 Membrane transport protein; Region: Mem_trans; pfam03547 748727006049 ketol-acid reductoisomerase; Provisional; Region: PRK05479 748727006050 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 748727006051 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 748727006052 ketol-acid reductoisomerase; Provisional; Region: PRK05479 748727006053 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 748727006054 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 748727006055 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 748727006056 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 748727006057 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 748727006058 PYR/PP interface [polypeptide binding]; other site 748727006059 dimer interface [polypeptide binding]; other site 748727006060 TPP binding site [chemical binding]; other site 748727006061 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748727006062 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 748727006063 TPP-binding site [chemical binding]; other site 748727006064 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 748727006065 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 748727006066 putative valine binding site [chemical binding]; other site 748727006067 dimer interface [polypeptide binding]; other site 748727006068 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 748727006069 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 748727006070 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727006071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727006072 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 748727006073 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 748727006074 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 748727006075 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727006076 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 748727006077 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748727006078 inhibitor-cofactor binding pocket; inhibition site 748727006079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727006080 catalytic residue [active] 748727006081 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 748727006082 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 748727006083 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 748727006084 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 748727006085 carboxyltransferase (CT) interaction site; other site 748727006086 biotinylation site [posttranslational modification]; other site 748727006087 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 748727006088 putative active site [active] 748727006089 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 748727006090 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 748727006091 Na binding site [ion binding]; other site 748727006092 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 748727006093 MFS/sugar transport protein; Region: MFS_2; pfam13347 748727006094 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 748727006095 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727006096 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 748727006097 B12 binding site [chemical binding]; other site 748727006098 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006099 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006100 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 748727006101 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748727006102 active site 748727006103 phosphorylation site [posttranslational modification] 748727006104 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 748727006105 active site 748727006106 P-loop; other site 748727006107 phosphorylation site [posttranslational modification] 748727006108 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 748727006109 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 748727006110 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 748727006111 putative substrate binding site [chemical binding]; other site 748727006112 putative ATP binding site [chemical binding]; other site 748727006113 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748727006114 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748727006115 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748727006116 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 748727006117 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 748727006118 substrate binding pocket [chemical binding]; other site 748727006119 dimer interface [polypeptide binding]; other site 748727006120 inhibitor binding site; inhibition site 748727006121 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 748727006122 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727006123 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 748727006124 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727006125 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 748727006126 B12 binding site [chemical binding]; other site 748727006127 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006128 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 748727006129 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 748727006130 substrate binding pocket [chemical binding]; other site 748727006131 dimer interface [polypeptide binding]; other site 748727006132 inhibitor binding site; inhibition site 748727006133 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 748727006134 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 748727006135 B12 binding site [chemical binding]; other site 748727006136 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727006138 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 748727006139 catalytic loop [active] 748727006140 iron binding site [ion binding]; other site 748727006141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727006142 nucleotide binding site [chemical binding]; other site 748727006143 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727006144 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 748727006145 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 748727006146 B12 binding site [chemical binding]; other site 748727006147 purine nucleoside phosphorylase; Provisional; Region: PRK08202 748727006148 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 748727006149 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 748727006150 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 748727006151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727006152 Response regulator receiver domain; Region: Response_reg; pfam00072 748727006153 active site 748727006154 phosphorylation site [posttranslational modification] 748727006155 intermolecular recognition site; other site 748727006156 dimerization interface [polypeptide binding]; other site 748727006157 YcbB domain; Region: YcbB; pfam08664 748727006158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727006159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727006160 ATP binding site [chemical binding]; other site 748727006161 G-X-G motif; other site 748727006162 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 748727006163 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 748727006164 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727006165 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748727006166 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727006167 nucleotide binding site [chemical binding]; other site 748727006168 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 748727006169 active site 748727006170 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 748727006171 nucleophile elbow; other site 748727006172 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 748727006173 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748727006174 active site 748727006175 HIGH motif; other site 748727006176 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748727006177 KMSKS motif; other site 748727006178 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748727006179 tRNA binding surface [nucleotide binding]; other site 748727006180 anticodon binding site; other site 748727006181 Ion channel; Region: Ion_trans_2; pfam07885 748727006182 HutD; Region: HutD; pfam05962 748727006183 CHASE4 domain; Region: CHASE4; pfam05228 748727006184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727006185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727006186 metal binding site [ion binding]; metal-binding site 748727006187 active site 748727006188 I-site; other site 748727006189 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727006190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727006191 Zn2+ binding site [ion binding]; other site 748727006192 Mg2+ binding site [ion binding]; other site 748727006193 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 748727006194 Predicted membrane protein [Function unknown]; Region: COG2323 748727006195 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 748727006196 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 748727006197 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 748727006198 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 748727006199 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 748727006200 classical (c) SDRs; Region: SDR_c; cd05233 748727006201 NAD(P) binding site [chemical binding]; other site 748727006202 active site 748727006203 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 748727006204 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 748727006205 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 748727006206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 748727006207 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 748727006208 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 748727006209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727006210 active site 748727006211 DNA binding site [nucleotide binding] 748727006212 Int/Topo IB signature motif; other site 748727006213 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 748727006214 LexA repressor; Validated; Region: PRK00215 748727006215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727006216 putative DNA binding site [nucleotide binding]; other site 748727006217 putative Zn2+ binding site [ion binding]; other site 748727006218 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 748727006219 Catalytic site [active] 748727006220 DNA polymerase IV; Reviewed; Region: PRK03103 748727006221 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 748727006222 active site 748727006223 DNA binding site [nucleotide binding] 748727006224 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 748727006225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727006226 putative DNA binding site [nucleotide binding]; other site 748727006227 putative Zn2+ binding site [ion binding]; other site 748727006228 AsnC family; Region: AsnC_trans_reg; pfam01037 748727006229 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727006230 MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307 748727006231 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727006232 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 748727006233 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 748727006234 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748727006235 B12 binding site [chemical binding]; other site 748727006236 cobalt ligand [ion binding]; other site 748727006237 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 748727006238 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 748727006239 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 748727006240 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727006241 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 748727006242 benzoate transport; Region: 2A0115; TIGR00895 748727006243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727006244 putative substrate translocation pore; other site 748727006245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727006246 benzoate transport; Region: 2A0115; TIGR00895 748727006247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727006248 putative substrate translocation pore; other site 748727006249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727006250 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 748727006251 putative deacylase active site [active] 748727006252 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006253 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727006254 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727006255 active site 748727006256 FMN binding site [chemical binding]; other site 748727006257 substrate binding site [chemical binding]; other site 748727006258 putative catalytic residue [active] 748727006259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727006260 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 748727006261 Aluminium resistance protein; Region: Alum_res; pfam06838 748727006262 bacterial Hfq-like; Region: Hfq; cd01716 748727006263 hexamer interface [polypeptide binding]; other site 748727006264 Sm1 motif; other site 748727006265 RNA binding site [nucleotide binding]; other site 748727006266 Sm2 motif; other site 748727006267 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 748727006268 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 748727006269 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 748727006270 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 748727006271 ATP binding site [chemical binding]; other site 748727006272 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 748727006273 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 748727006274 MutS domain I; Region: MutS_I; pfam01624 748727006275 MutS domain II; Region: MutS_II; pfam05188 748727006276 MutS domain III; Region: MutS_III; pfam05192 748727006277 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 748727006278 Walker A/P-loop; other site 748727006279 ATP binding site [chemical binding]; other site 748727006280 Q-loop/lid; other site 748727006281 ABC transporter signature motif; other site 748727006282 Walker B; other site 748727006283 D-loop; other site 748727006284 H-loop/switch region; other site 748727006285 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 748727006286 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748727006287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727006288 FeS/SAM binding site; other site 748727006289 TRAM domain; Region: TRAM; pfam01938 748727006290 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 748727006291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727006292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727006293 homodimer interface [polypeptide binding]; other site 748727006294 catalytic residue [active] 748727006295 aspartate aminotransferase; Provisional; Region: PRK07568 748727006296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727006297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727006298 homodimer interface [polypeptide binding]; other site 748727006299 catalytic residue [active] 748727006300 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 748727006301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727006302 Coenzyme A binding pocket [chemical binding]; other site 748727006303 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 748727006304 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 748727006305 LytB protein; Region: LYTB; cl00507 748727006306 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 748727006307 RNA binding site [nucleotide binding]; other site 748727006308 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 748727006309 RNA binding site [nucleotide binding]; other site 748727006310 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 748727006311 RNA binding site [nucleotide binding]; other site 748727006312 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 748727006313 RNA binding site [nucleotide binding]; other site 748727006314 cytidylate kinase; Provisional; Region: cmk; PRK00023 748727006315 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 748727006316 CMP-binding site; other site 748727006317 The sites determining sugar specificity; other site 748727006318 HI0933-like protein; Region: HI0933_like; pfam03486 748727006319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727006320 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748727006321 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748727006322 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748727006323 putative active site [active] 748727006324 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748727006325 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 748727006326 active site 748727006327 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 748727006328 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 748727006329 DXD motif; other site 748727006330 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 748727006331 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 748727006332 CPxP motif; other site 748727006333 DsrE/DsrF-like family; Region: DrsE; pfam02635 748727006334 Predicted amidohydrolase [General function prediction only]; Region: COG0388 748727006335 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 748727006336 putative active site [active] 748727006337 catalytic triad [active] 748727006338 dimer interface [polypeptide binding]; other site 748727006339 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 748727006340 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 748727006341 putative ATP binding site [chemical binding]; other site 748727006342 putative substrate interface [chemical binding]; other site 748727006343 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 748727006344 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 748727006345 GTP binding site; other site 748727006346 formimidoylglutamase; Provisional; Region: PRK13775 748727006347 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 748727006348 putative active site [active] 748727006349 putative metal binding site [ion binding]; other site 748727006350 Cache domain; Region: Cache_1; pfam02743 748727006351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727006352 dimerization interface [polypeptide binding]; other site 748727006353 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727006354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727006355 dimer interface [polypeptide binding]; other site 748727006356 putative CheW interface [polypeptide binding]; other site 748727006357 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 748727006358 amino acid transporter; Region: 2A0306; TIGR00909 748727006359 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727006360 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 748727006361 active sites [active] 748727006362 tetramer interface [polypeptide binding]; other site 748727006363 imidazolonepropionase; Validated; Region: PRK09356 748727006364 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 748727006365 active site 748727006366 urocanate hydratase; Provisional; Region: PRK05414 748727006367 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 748727006368 Predicted ATPase [General function prediction only]; Region: COG3899 748727006369 AAA ATPase domain; Region: AAA_16; pfam13191 748727006370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727006371 TPR motif; other site 748727006372 binding surface 748727006373 glutamate formiminotransferase; Region: FtcD; TIGR02024 748727006374 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 748727006375 Formiminotransferase domain; Region: FTCD; pfam02971 748727006376 acetylornithine aminotransferase; Provisional; Region: PRK02627 748727006377 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748727006378 inhibitor-cofactor binding pocket; inhibition site 748727006379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727006380 catalytic residue [active] 748727006381 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 748727006382 feedback inhibition sensing region; other site 748727006383 homohexameric interface [polypeptide binding]; other site 748727006384 nucleotide binding site [chemical binding]; other site 748727006385 N-acetyl-L-glutamate binding site [chemical binding]; other site 748727006386 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 748727006387 heterotetramer interface [polypeptide binding]; other site 748727006388 active site pocket [active] 748727006389 cleavage site 748727006390 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 748727006391 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 748727006392 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 748727006393 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 748727006394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727006395 ATP binding site [chemical binding]; other site 748727006396 putative Mg++ binding site [ion binding]; other site 748727006397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727006398 nucleotide binding region [chemical binding]; other site 748727006399 ATP-binding site [chemical binding]; other site 748727006400 Hemerythrin-like domain; Region: Hr-like; cd12108 748727006401 Fe binding site [ion binding]; other site 748727006402 FAD binding domain; Region: FAD_binding_4; pfam01565 748727006403 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 748727006404 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 748727006405 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 748727006406 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 748727006407 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 748727006408 Ligand binding site [chemical binding]; other site 748727006409 Electron transfer flavoprotein domain; Region: ETF; pfam01012 748727006410 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 748727006411 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 748727006412 L-lactate permease; Region: Lactate_perm; cl00701 748727006413 Transcriptional regulators [Transcription]; Region: FadR; COG2186 748727006414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727006415 DNA-binding site [nucleotide binding]; DNA binding site 748727006416 FCD domain; Region: FCD; pfam07729 748727006417 RNase_H superfamily; Region: RNase_H_2; pfam13482 748727006418 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 748727006419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727006420 motif II; other site 748727006421 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 748727006422 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 748727006423 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 748727006424 G1 box; other site 748727006425 GTP/Mg2+ binding site [chemical binding]; other site 748727006426 Switch I region; other site 748727006427 G2 box; other site 748727006428 G3 box; other site 748727006429 Switch II region; other site 748727006430 G4 box; other site 748727006431 G5 box; other site 748727006432 Nucleoside recognition; Region: Gate; pfam07670 748727006433 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 748727006434 Nucleoside recognition; Region: Gate; pfam07670 748727006435 FOG: CBS domain [General function prediction only]; Region: COG0517 748727006436 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 748727006437 RNase_H superfamily; Region: RNase_H_2; pfam13482 748727006438 active site 748727006439 substrate binding site [chemical binding]; other site 748727006440 catalytic site [active] 748727006441 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 748727006442 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 748727006443 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 748727006444 active site 748727006445 HIGH motif; other site 748727006446 KMSK motif region; other site 748727006447 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 748727006448 tRNA binding surface [nucleotide binding]; other site 748727006449 anticodon binding site; other site 748727006450 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 748727006451 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 748727006452 NAD binding site [chemical binding]; other site 748727006453 homodimer interface [polypeptide binding]; other site 748727006454 active site 748727006455 substrate binding site [chemical binding]; other site 748727006456 D-glutamate deacylase; Validated; Region: PRK09061 748727006457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727006458 active site 748727006459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727006460 potential frameshift: common BLAST hit: gi|153936910|ref|YP_001386501.1| spermidine/putrescine ABC transporter, permease 748727006461 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 748727006462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748727006463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748727006464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006465 dimer interface [polypeptide binding]; other site 748727006466 conserved gate region; other site 748727006467 putative PBP binding loops; other site 748727006468 ABC-ATPase subunit interface; other site 748727006469 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 748727006470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006471 dimer interface [polypeptide binding]; other site 748727006472 conserved gate region; other site 748727006473 putative PBP binding loops; other site 748727006474 ABC-ATPase subunit interface; other site 748727006475 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748727006476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727006477 Walker A/P-loop; other site 748727006478 ATP binding site [chemical binding]; other site 748727006479 Q-loop/lid; other site 748727006480 ABC transporter signature motif; other site 748727006481 Walker B; other site 748727006482 D-loop; other site 748727006483 H-loop/switch region; other site 748727006484 TOBE domain; Region: TOBE_2; pfam08402 748727006485 Predicted membrane protein [Function unknown]; Region: COG3428 748727006486 Bacterial PH domain; Region: DUF304; pfam03703 748727006487 Bacterial PH domain; Region: DUF304; pfam03703 748727006488 Bacterial PH domain; Region: DUF304; cl01348 748727006489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727006490 dimerization interface [polypeptide binding]; other site 748727006491 putative DNA binding site [nucleotide binding]; other site 748727006492 putative Zn2+ binding site [ion binding]; other site 748727006493 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 748727006494 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 748727006495 active site 748727006496 catalytic site [active] 748727006497 lysine transporter; Provisional; Region: PRK10836 748727006498 MutS domain III; Region: MutS_III; pfam05192 748727006499 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 748727006500 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 748727006501 Walker A/P-loop; other site 748727006502 ATP binding site [chemical binding]; other site 748727006503 Q-loop/lid; other site 748727006504 ABC transporter signature motif; other site 748727006505 Walker B; other site 748727006506 D-loop; other site 748727006507 H-loop/switch region; other site 748727006508 Hemerythrin; Region: Hemerythrin; cd12107 748727006509 Fe binding site [ion binding]; other site 748727006510 Membrane protein of unknown function; Region: DUF360; pfam04020 748727006511 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727006512 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 748727006513 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748727006514 active site 748727006515 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748727006516 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 748727006517 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 748727006518 oligomer interface [polypeptide binding]; other site 748727006519 putative active site [active] 748727006520 metal binding site [ion binding]; metal-binding site 748727006521 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 748727006522 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 748727006523 oligomer interface [polypeptide binding]; other site 748727006524 metal binding site [ion binding]; metal-binding site 748727006525 metal binding site [ion binding]; metal-binding site 748727006526 putative Cl binding site [ion binding]; other site 748727006527 aspartate ring; other site 748727006528 basic sphincter; other site 748727006529 hydrophobic gate; other site 748727006530 periplasmic entrance; other site 748727006531 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 748727006532 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 748727006533 HPr kinase/phosphorylase; Provisional; Region: PRK05428 748727006534 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 748727006535 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 748727006536 Hpr binding site; other site 748727006537 active site 748727006538 homohexamer subunit interaction site [polypeptide binding]; other site 748727006539 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 748727006540 Arginase family; Region: Arginase; cd09989 748727006541 active site 748727006542 Mn binding site [ion binding]; other site 748727006543 oligomer interface [polypeptide binding]; other site 748727006544 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 748727006545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727006546 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727006547 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 748727006548 Part of AAA domain; Region: AAA_19; pfam13245 748727006549 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748727006550 active site 748727006551 catalytic residues [active] 748727006552 metal binding site [ion binding]; metal-binding site 748727006553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727006554 Response regulator receiver domain; Region: Response_reg; pfam00072 748727006555 active site 748727006556 phosphorylation site [posttranslational modification] 748727006557 intermolecular recognition site; other site 748727006558 dimerization interface [polypeptide binding]; other site 748727006559 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 748727006560 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 748727006561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727006562 FeS/SAM binding site; other site 748727006563 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 748727006564 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 748727006565 Zn binding site [ion binding]; other site 748727006566 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 748727006567 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 748727006568 diiron binding motif [ion binding]; other site 748727006569 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 748727006570 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 748727006571 homopentamer interface [polypeptide binding]; other site 748727006572 active site 748727006573 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 748727006574 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 748727006575 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 748727006576 dimerization interface [polypeptide binding]; other site 748727006577 active site 748727006578 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 748727006579 Lumazine binding domain; Region: Lum_binding; pfam00677 748727006580 Lumazine binding domain; Region: Lum_binding; pfam00677 748727006581 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 748727006582 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 748727006583 catalytic motif [active] 748727006584 Zn binding site [ion binding]; other site 748727006585 RibD C-terminal domain; Region: RibD_C; cl17279 748727006586 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727006587 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727006588 dimerization interface [polypeptide binding]; other site 748727006589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727006590 dimer interface [polypeptide binding]; other site 748727006591 putative CheW interface [polypeptide binding]; other site 748727006592 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 748727006593 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 748727006594 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 748727006595 putative binding surface; other site 748727006596 active site 748727006597 P2 response regulator binding domain; Region: P2; pfam07194 748727006598 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 748727006599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727006600 ATP binding site [chemical binding]; other site 748727006601 Mg2+ binding site [ion binding]; other site 748727006602 G-X-G motif; other site 748727006603 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 748727006604 Response regulator receiver domain; Region: Response_reg; pfam00072 748727006605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727006606 active site 748727006607 phosphorylation site [posttranslational modification] 748727006608 intermolecular recognition site; other site 748727006609 dimerization interface [polypeptide binding]; other site 748727006610 molybdenum-pterin binding domain; Region: Mop; TIGR00638 748727006611 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 748727006612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727006613 Walker A/P-loop; other site 748727006614 ATP binding site [chemical binding]; other site 748727006615 Q-loop/lid; other site 748727006616 ABC transporter signature motif; other site 748727006617 Walker B; other site 748727006618 D-loop; other site 748727006619 H-loop/switch region; other site 748727006620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006621 dimer interface [polypeptide binding]; other site 748727006622 conserved gate region; other site 748727006623 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 748727006624 putative PBP binding loops; other site 748727006625 ABC-ATPase subunit interface; other site 748727006626 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 748727006627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748727006628 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 748727006629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727006630 Walker A/P-loop; other site 748727006631 ATP binding site [chemical binding]; other site 748727006632 Q-loop/lid; other site 748727006633 ABC transporter signature motif; other site 748727006634 Walker B; other site 748727006635 D-loop; other site 748727006636 H-loop/switch region; other site 748727006637 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748727006638 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 748727006639 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748727006640 metal binding site [ion binding]; metal-binding site 748727006641 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 748727006642 cobalt transport protein CbiM; Validated; Region: PRK08319 748727006643 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 748727006644 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 748727006645 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 748727006646 Metal-binding active site; metal-binding site 748727006647 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 748727006648 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727006649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727006650 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727006651 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006652 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006653 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006654 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 748727006655 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 748727006656 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 748727006657 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748727006658 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748727006659 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727006660 Walker A/P-loop; other site 748727006661 ATP binding site [chemical binding]; other site 748727006662 Q-loop/lid; other site 748727006663 ABC transporter signature motif; other site 748727006664 Walker B; other site 748727006665 D-loop; other site 748727006666 H-loop/switch region; other site 748727006667 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727006668 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 748727006669 Walker A/P-loop; other site 748727006670 ATP binding site [chemical binding]; other site 748727006671 Q-loop/lid; other site 748727006672 ABC transporter signature motif; other site 748727006673 Walker B; other site 748727006674 D-loop; other site 748727006675 H-loop/switch region; other site 748727006676 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748727006677 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006678 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006679 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006680 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006681 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006682 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006683 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 748727006684 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 748727006685 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 748727006686 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 748727006687 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006688 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006689 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006690 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006691 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006692 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006693 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006694 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006695 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006696 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727006697 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006698 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006699 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006700 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 748727006701 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006702 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006703 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006704 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 748727006705 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006706 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 748727006707 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006708 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006709 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006710 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006711 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727006712 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727006713 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 748727006714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748727006715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727006716 Coenzyme A binding pocket [chemical binding]; other site 748727006717 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727006718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727006719 Walker A/P-loop; other site 748727006720 ATP binding site [chemical binding]; other site 748727006721 ABC transporter; Region: ABC_tran; pfam00005 748727006722 Q-loop/lid; other site 748727006723 ABC transporter signature motif; other site 748727006724 Walker B; other site 748727006725 D-loop; other site 748727006726 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 748727006727 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727006728 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748727006729 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727006730 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727006731 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 748727006732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727006733 S-adenosylmethionine binding site [chemical binding]; other site 748727006734 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748727006735 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 748727006736 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 748727006737 Zn binding site [ion binding]; other site 748727006738 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 748727006739 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748727006740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727006741 Walker A/P-loop; other site 748727006742 ATP binding site [chemical binding]; other site 748727006743 Q-loop/lid; other site 748727006744 ABC transporter signature motif; other site 748727006745 Walker B; other site 748727006746 D-loop; other site 748727006747 H-loop/switch region; other site 748727006748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748727006749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727006750 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 748727006751 Walker A/P-loop; other site 748727006752 ATP binding site [chemical binding]; other site 748727006753 Q-loop/lid; other site 748727006754 ABC transporter signature motif; other site 748727006755 Walker B; other site 748727006756 D-loop; other site 748727006757 H-loop/switch region; other site 748727006758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748727006759 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748727006760 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 748727006761 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 748727006762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006763 dimer interface [polypeptide binding]; other site 748727006764 conserved gate region; other site 748727006765 putative PBP binding loops; other site 748727006766 ABC-ATPase subunit interface; other site 748727006767 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748727006768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006769 dimer interface [polypeptide binding]; other site 748727006770 conserved gate region; other site 748727006771 putative PBP binding loops; other site 748727006772 ABC-ATPase subunit interface; other site 748727006773 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727006774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727006775 S-adenosylmethionine binding site [chemical binding]; other site 748727006776 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 748727006777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727006778 Walker A/P-loop; other site 748727006779 ATP binding site [chemical binding]; other site 748727006780 Q-loop/lid; other site 748727006781 ABC transporter signature motif; other site 748727006782 Walker B; other site 748727006783 D-loop; other site 748727006784 H-loop/switch region; other site 748727006785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748727006786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748727006787 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 748727006788 Walker A/P-loop; other site 748727006789 ATP binding site [chemical binding]; other site 748727006790 Q-loop/lid; other site 748727006791 ABC transporter signature motif; other site 748727006792 Walker B; other site 748727006793 D-loop; other site 748727006794 H-loop/switch region; other site 748727006795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748727006796 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 748727006797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006798 dimer interface [polypeptide binding]; other site 748727006799 conserved gate region; other site 748727006800 putative PBP binding loops; other site 748727006801 ABC-ATPase subunit interface; other site 748727006802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748727006803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727006804 dimer interface [polypeptide binding]; other site 748727006805 conserved gate region; other site 748727006806 putative PBP binding loops; other site 748727006807 ABC-ATPase subunit interface; other site 748727006808 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748727006809 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 748727006810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727006811 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 748727006812 Walker A motif; other site 748727006813 ATP binding site [chemical binding]; other site 748727006814 Walker B motif; other site 748727006815 arginine finger; other site 748727006816 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727006817 Methyltransferase domain; Region: Methyltransf_23; pfam13489 748727006818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727006819 S-adenosylmethionine binding site [chemical binding]; other site 748727006820 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748727006821 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 748727006822 MFS/sugar transport protein; Region: MFS_2; pfam13347 748727006823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727006824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727006825 putative substrate translocation pore; other site 748727006826 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727006827 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727006828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727006829 FeS/SAM binding site; other site 748727006830 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748727006831 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727006832 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727006833 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 748727006834 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 748727006835 putative hexamer interface [polypeptide binding]; other site 748727006836 putative hexagonal pore; other site 748727006837 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 748727006838 putative hexamer interface [polypeptide binding]; other site 748727006839 putative hexagonal pore; other site 748727006840 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 748727006841 L-aspartate oxidase; Provisional; Region: PRK06175 748727006842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 748727006843 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 748727006844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 748727006845 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727006846 MarR family; Region: MarR; pfam01047 748727006847 MarR family; Region: MarR_2; cl17246 748727006848 Uncharacterized conserved protein [Function unknown]; Region: COG1434 748727006849 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 748727006850 putative active site [active] 748727006851 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727006852 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 748727006853 putative active site [active] 748727006854 putative metal binding site [ion binding]; other site 748727006855 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748727006856 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 748727006857 dimerization interface [polypeptide binding]; other site 748727006858 Cache domain; Region: Cache_1; pfam02743 748727006859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727006860 dimerization interface [polypeptide binding]; other site 748727006861 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727006862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727006863 dimer interface [polypeptide binding]; other site 748727006864 putative CheW interface [polypeptide binding]; other site 748727006865 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 748727006866 active site 748727006867 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 748727006868 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727006869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727006870 dimerization interface [polypeptide binding]; other site 748727006871 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727006872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727006873 dimer interface [polypeptide binding]; other site 748727006874 putative CheW interface [polypeptide binding]; other site 748727006875 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727006876 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 748727006877 Walker A/P-loop; other site 748727006878 ATP binding site [chemical binding]; other site 748727006879 Q-loop/lid; other site 748727006880 ABC transporter signature motif; other site 748727006881 Walker B; other site 748727006882 D-loop; other site 748727006883 H-loop/switch region; other site 748727006884 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 748727006885 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727006886 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 748727006887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727006888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727006889 active site 748727006890 phosphorylation site [posttranslational modification] 748727006891 intermolecular recognition site; other site 748727006892 dimerization interface [polypeptide binding]; other site 748727006893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727006894 DNA binding site [nucleotide binding] 748727006895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727006896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727006897 dimer interface [polypeptide binding]; other site 748727006898 phosphorylation site [posttranslational modification] 748727006899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727006900 ATP binding site [chemical binding]; other site 748727006901 Mg2+ binding site [ion binding]; other site 748727006902 G-X-G motif; other site 748727006903 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 748727006904 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 748727006905 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 748727006906 active site 748727006907 putative interdomain interaction site [polypeptide binding]; other site 748727006908 putative metal-binding site [ion binding]; other site 748727006909 putative nucleotide binding site [chemical binding]; other site 748727006910 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 748727006911 domain I; other site 748727006912 DNA binding groove [nucleotide binding] 748727006913 phosphate binding site [ion binding]; other site 748727006914 domain II; other site 748727006915 domain III; other site 748727006916 nucleotide binding site [chemical binding]; other site 748727006917 catalytic site [active] 748727006918 domain IV; other site 748727006919 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 748727006920 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 748727006921 DEAD-like helicases superfamily; Region: DEXDc; smart00487 748727006922 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 748727006923 ATP binding site [chemical binding]; other site 748727006924 Mg++ binding site [ion binding]; other site 748727006925 motif III; other site 748727006926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727006927 nucleotide binding region [chemical binding]; other site 748727006928 ATP-binding site [chemical binding]; other site 748727006929 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 748727006930 hypothetical protein; Provisional; Region: PRK02399 748727006931 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 748727006932 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 748727006933 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727006934 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727006935 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727006936 nitrogenase reductase-like protein; Reviewed; Region: PRK13231 748727006937 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727006938 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 748727006939 dimerization interface [polypeptide binding]; other site 748727006940 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 748727006941 ATP binding site [chemical binding]; other site 748727006942 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 748727006943 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 748727006944 HupF/HypC family; Region: HupF_HypC; pfam01455 748727006945 Acylphosphatase; Region: Acylphosphatase; pfam00708 748727006946 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 748727006947 HypF finger; Region: zf-HYPF; pfam07503 748727006948 HypF finger; Region: zf-HYPF; pfam07503 748727006949 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 748727006950 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727006951 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727006952 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727006953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727006954 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 748727006955 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 748727006956 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 748727006957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727006958 non-specific DNA binding site [nucleotide binding]; other site 748727006959 salt bridge; other site 748727006960 sequence-specific DNA binding site [nucleotide binding]; other site 748727006961 Cupin domain; Region: Cupin_2; pfam07883 748727006962 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 748727006963 Isochorismatase family; Region: Isochorismatase; pfam00857 748727006964 catalytic triad [active] 748727006965 conserved cis-peptide bond; other site 748727006966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 748727006967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 748727006968 active site 748727006969 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 748727006970 putative transporter; Provisional; Region: PRK10484 748727006971 Na binding site [ion binding]; other site 748727006972 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 748727006973 FAD binding domain; Region: FAD_binding_4; pfam01565 748727006974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 748727006975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 748727006976 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 748727006977 putative metal binding site [ion binding]; other site 748727006978 putative dimer interface [polypeptide binding]; other site 748727006979 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727006980 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 748727006981 putative NAD(P) binding site [chemical binding]; other site 748727006982 catalytic Zn binding site [ion binding]; other site 748727006983 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 748727006984 GAF domain; Region: GAF; pfam01590 748727006985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727006986 Walker A motif; other site 748727006987 ATP binding site [chemical binding]; other site 748727006988 Walker B motif; other site 748727006989 arginine finger; other site 748727006990 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727006991 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 748727006992 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 748727006993 Cl- selectivity filter; other site 748727006994 Cl- binding residues [ion binding]; other site 748727006995 pore gating glutamate residue; other site 748727006996 dimer interface [polypeptide binding]; other site 748727006997 H+/Cl- coupling transport residue; other site 748727006998 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748727006999 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727007000 Walker A/P-loop; other site 748727007001 ATP binding site [chemical binding]; other site 748727007002 Q-loop/lid; other site 748727007003 ABC transporter signature motif; other site 748727007004 Walker B; other site 748727007005 D-loop; other site 748727007006 H-loop/switch region; other site 748727007007 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748727007008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748727007009 HlyD family secretion protein; Region: HlyD_3; pfam13437 748727007010 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 748727007011 Protein export membrane protein; Region: SecD_SecF; cl14618 748727007012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727007013 MarR family; Region: MarR; pfam01047 748727007014 AAA ATPase domain; Region: AAA_16; pfam13191 748727007015 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 748727007016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748727007017 DNA binding residues [nucleotide binding] 748727007018 dimerization interface [polypeptide binding]; other site 748727007019 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 748727007020 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 748727007021 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 748727007022 metal ion-dependent adhesion site (MIDAS); other site 748727007023 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1810 748727007024 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 748727007025 camphor resistance protein CrcB; Provisional; Region: PRK14232 748727007026 potential frameshift: common BLAST hit: gi|295706054|ref|YP_003599129.1| rhizopine catabolism regulatory protein mocR 748727007027 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727007028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727007029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727007030 homodimer interface [polypeptide binding]; other site 748727007031 catalytic residue [active] 748727007032 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727007033 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 748727007034 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 748727007035 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748727007036 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748727007037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727007038 catalytic residue [active] 748727007039 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 748727007040 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 748727007041 PYR/PP interface [polypeptide binding]; other site 748727007042 dimer interface [polypeptide binding]; other site 748727007043 TPP binding site [chemical binding]; other site 748727007044 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748727007045 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 748727007046 TPP-binding site [chemical binding]; other site 748727007047 dimer interface [polypeptide binding]; other site 748727007048 amino acid transporter; Region: 2A0306; TIGR00909 748727007049 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 748727007050 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727007051 hypothetical protein; Region: PHA00727 748727007052 amino acid transporter; Region: 2A0306; TIGR00909 748727007053 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 748727007054 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748727007055 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 748727007056 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 748727007057 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 748727007058 dimer interface [polypeptide binding]; other site 748727007059 active site 748727007060 metal binding site [ion binding]; metal-binding site 748727007061 DNA topoisomerase III; Provisional; Region: PRK07726 748727007062 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 748727007063 active site 748727007064 putative interdomain interaction site [polypeptide binding]; other site 748727007065 putative metal-binding site [ion binding]; other site 748727007066 putative nucleotide binding site [chemical binding]; other site 748727007067 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 748727007068 domain I; other site 748727007069 DNA binding groove [nucleotide binding] 748727007070 phosphate binding site [ion binding]; other site 748727007071 domain II; other site 748727007072 domain III; other site 748727007073 nucleotide binding site [chemical binding]; other site 748727007074 catalytic site [active] 748727007075 domain IV; other site 748727007076 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 748727007077 S-ribosylhomocysteinase; Provisional; Region: PRK02260 748727007078 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 748727007080 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 748727007081 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 748727007082 Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971 748727007083 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727007084 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 748727007085 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 748727007086 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 748727007087 nitrogenase iron protein; Region: nifH; TIGR01287 748727007088 Nucleotide-binding sites [chemical binding]; other site 748727007089 Walker A motif; other site 748727007090 Switch I region of nucleotide binding site; other site 748727007091 Fe4S4 binding sites [ion binding]; other site 748727007092 Switch II region of nucleotide binding site; other site 748727007093 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 748727007094 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 748727007095 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 748727007096 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 748727007097 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 748727007098 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 748727007099 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 748727007100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 748727007101 carbamate kinase; Reviewed; Region: PRK12686 748727007102 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727007103 putative substrate binding site [chemical binding]; other site 748727007104 nucleotide binding site [chemical binding]; other site 748727007105 nucleotide binding site [chemical binding]; other site 748727007106 homodimer interface [polypeptide binding]; other site 748727007107 uracil transporter; Provisional; Region: PRK10720 748727007108 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748727007109 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727007110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727007111 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748727007112 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727007113 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 748727007114 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 748727007115 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 748727007116 DUF35 OB-fold domain; Region: DUF35; pfam01796 748727007117 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 748727007118 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 748727007119 active site 748727007120 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 748727007121 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 748727007122 membrane protein FdrA; Validated; Region: PRK06091 748727007123 CoA binding domain; Region: CoA_binding; pfam02629 748727007124 CoA-ligase; Region: Ligase_CoA; pfam00549 748727007125 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 748727007126 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 748727007127 DRTGG domain; Region: DRTGG; pfam07085 748727007128 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727007129 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 748727007130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727007131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727007132 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 748727007133 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 748727007134 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 748727007135 [4Fe-4S] binding site [ion binding]; other site 748727007136 molybdopterin cofactor binding site; other site 748727007137 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 748727007138 molybdopterin cofactor binding site; other site 748727007139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727007140 putative substrate translocation pore; other site 748727007141 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 748727007142 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748727007143 4Fe-4S binding domain; Region: Fer4; pfam00037 748727007144 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 748727007145 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 748727007146 FAD binding pocket [chemical binding]; other site 748727007147 FAD binding motif [chemical binding]; other site 748727007148 phosphate binding motif [ion binding]; other site 748727007149 beta-alpha-beta structure motif; other site 748727007150 NAD binding pocket [chemical binding]; other site 748727007151 Iron coordination center [ion binding]; other site 748727007152 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 748727007153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748727007154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748727007155 ligand binding site [chemical binding]; other site 748727007156 flexible hinge region; other site 748727007157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748727007158 putative switch regulator; other site 748727007159 non-specific DNA interactions [nucleotide binding]; other site 748727007160 DNA binding site [nucleotide binding] 748727007161 sequence specific DNA binding site [nucleotide binding]; other site 748727007162 putative cAMP binding site [chemical binding]; other site 748727007163 phenylhydantoinase; Validated; Region: PRK08323 748727007164 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 748727007165 tetramer interface [polypeptide binding]; other site 748727007166 active site 748727007167 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727007168 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 748727007169 putative substrate binding site [chemical binding]; other site 748727007170 nucleotide binding site [chemical binding]; other site 748727007171 nucleotide binding site [chemical binding]; other site 748727007172 homodimer interface [polypeptide binding]; other site 748727007173 peptidase; Reviewed; Region: PRK13004 748727007174 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 748727007175 putative metal binding site [ion binding]; other site 748727007176 putative dimer interface [polypeptide binding]; other site 748727007177 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 748727007178 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 748727007179 active site 748727007180 putative substrate binding pocket [chemical binding]; other site 748727007181 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 748727007182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727007183 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 748727007184 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727007185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727007186 xanthine permease; Region: pbuX; TIGR03173 748727007187 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 748727007188 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 748727007189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727007190 catalytic residue [active] 748727007191 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 748727007192 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 748727007193 active site 748727007194 putative substrate binding pocket [chemical binding]; other site 748727007195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727007196 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 748727007197 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 748727007198 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748727007199 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727007200 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748727007201 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727007202 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727007203 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 748727007204 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 748727007205 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727007206 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727007207 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727007208 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 748727007209 Ligand binding site; other site 748727007210 metal-binding site 748727007211 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 748727007212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727007213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727007214 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 748727007215 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 748727007216 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727007217 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 748727007218 active site 748727007219 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 748727007220 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748727007221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727007222 guanine deaminase; Region: guan_deamin; TIGR02967 748727007223 active site 748727007224 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 748727007225 PAS domain; Region: PAS; smart00091 748727007226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007227 Walker A motif; other site 748727007228 ATP binding site [chemical binding]; other site 748727007229 Walker B motif; other site 748727007230 arginine finger; other site 748727007231 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727007232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748727007233 catalytic core [active] 748727007234 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 748727007235 Ligand binding site; other site 748727007236 metal-binding site 748727007237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727007238 Zn2+ binding site [ion binding]; other site 748727007239 Mg2+ binding site [ion binding]; other site 748727007240 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 748727007241 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 748727007242 XdhC Rossmann domain; Region: XdhC_C; pfam13478 748727007243 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 748727007244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 748727007245 acyl-activating enzyme (AAE) consensus motif; other site 748727007246 active site 748727007247 AMP binding site [chemical binding]; other site 748727007248 CoA binding site [chemical binding]; other site 748727007249 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 748727007250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727007251 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727007252 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 748727007253 Cysteine-rich domain; Region: CCG; pfam02754 748727007254 Cysteine-rich domain; Region: CCG; pfam02754 748727007255 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748727007256 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727007257 catalytic loop [active] 748727007258 iron binding site [ion binding]; other site 748727007259 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727007260 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748727007261 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727007262 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727007263 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748727007264 PAS domain; Region: PAS; smart00091 748727007265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007266 Walker A motif; other site 748727007267 ATP binding site [chemical binding]; other site 748727007268 Walker B motif; other site 748727007269 arginine finger; other site 748727007270 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727007271 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 748727007272 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 748727007273 XdhC Rossmann domain; Region: XdhC_C; pfam13478 748727007274 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 748727007275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727007276 FeS/SAM binding site; other site 748727007277 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 748727007278 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727007279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727007280 S-adenosylmethionine binding site [chemical binding]; other site 748727007281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727007282 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 748727007283 Cysteine-rich domain; Region: CCG; pfam02754 748727007284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727007285 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748727007286 catalytic loop [active] 748727007287 iron binding site [ion binding]; other site 748727007288 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727007289 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748727007290 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727007291 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727007292 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748727007293 PAS domain; Region: PAS; smart00091 748727007294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007295 Walker A motif; other site 748727007296 ATP binding site [chemical binding]; other site 748727007297 Walker B motif; other site 748727007298 arginine finger; other site 748727007299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727007300 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 748727007301 tetramer interface [polypeptide binding]; other site 748727007302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727007303 catalytic residue [active] 748727007304 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 748727007305 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 748727007306 tetramer interface [polypeptide binding]; other site 748727007307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727007308 catalytic residue [active] 748727007309 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 748727007310 lipoyl attachment site [posttranslational modification]; other site 748727007311 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 748727007312 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 748727007313 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 748727007314 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 748727007315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727007316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727007317 putative hydratase; Provisional; Region: PRK11413 748727007318 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 748727007319 substrate binding site [chemical binding]; other site 748727007320 ligand binding site [chemical binding]; other site 748727007321 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 748727007322 substrate binding site [chemical binding]; other site 748727007323 PHP domain; Region: PHP; pfam02811 748727007324 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748727007325 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748727007326 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 748727007327 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748727007328 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748727007329 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727007330 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727007331 active site 748727007332 FMN binding site [chemical binding]; other site 748727007333 substrate binding site [chemical binding]; other site 748727007334 putative catalytic residue [active] 748727007335 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727007336 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 748727007337 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 748727007338 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727007339 putative active site [active] 748727007340 putative metal binding site [ion binding]; other site 748727007341 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727007342 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727007343 dimerization interface [polypeptide binding]; other site 748727007344 putative DNA binding site [nucleotide binding]; other site 748727007345 putative Zn2+ binding site [ion binding]; other site 748727007346 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 748727007347 NADH kinase; Region: PLN02929 748727007348 SPFH domain / Band 7 family; Region: Band_7; pfam01145 748727007349 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727007350 Homoserine O-succinyltransferase; Region: HTS; pfam04204 748727007351 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 748727007352 proposed active site lysine [active] 748727007353 conserved cys residue [active] 748727007354 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727007355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727007356 dimer interface [polypeptide binding]; other site 748727007357 putative CheW interface [polypeptide binding]; other site 748727007358 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 748727007359 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 748727007360 lysine transporter; Provisional; Region: PRK10836 748727007361 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 748727007362 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 748727007363 dimer interface [polypeptide binding]; other site 748727007364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727007365 catalytic residue [active] 748727007366 cystathionine beta-lyase; Provisional; Region: PRK07671 748727007367 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 748727007368 homodimer interface [polypeptide binding]; other site 748727007369 substrate-cofactor binding pocket; other site 748727007370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727007371 catalytic residue [active] 748727007372 Methyltransferase domain; Region: Methyltransf_23; pfam13489 748727007373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727007374 S-adenosylmethionine binding site [chemical binding]; other site 748727007375 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 748727007376 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 748727007377 dimerization interface [polypeptide binding]; other site 748727007378 active site 748727007379 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 748727007380 L-aspartate oxidase; Provisional; Region: PRK06175 748727007381 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 748727007382 Quinolinate synthetase A protein; Region: NadA; pfam02445 748727007383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727007384 dimer interface [polypeptide binding]; other site 748727007385 putative CheW interface [polypeptide binding]; other site 748727007386 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 748727007387 serpin-like protein; Provisional; Region: PHA02660 748727007388 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 748727007389 reactive center loop; other site 748727007390 BioY family; Region: BioY; pfam02632 748727007391 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 748727007392 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 748727007393 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 748727007394 folate binding site [chemical binding]; other site 748727007395 NADP+ binding site [chemical binding]; other site 748727007396 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 748727007397 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 748727007398 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727007399 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727007400 FMN-binding domain; Region: FMN_bind; cl01081 748727007401 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 748727007402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727007403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727007404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727007405 S-adenosylmethionine binding site [chemical binding]; other site 748727007406 potential frameshift: common BLAST hit: gi|269118847|ref|YP_003307024.1| major facilitator superfamily MFS_1 748727007407 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727007408 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727007409 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 748727007410 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 748727007411 active site 748727007412 substrate binding site [chemical binding]; other site 748727007413 trimer interface [polypeptide binding]; other site 748727007414 CoA binding site [chemical binding]; other site 748727007415 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748727007416 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 748727007417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727007418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727007419 S-adenosylmethionine binding site [chemical binding]; other site 748727007420 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 748727007421 nudix motif; other site 748727007422 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 748727007423 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 748727007424 nudix motif; other site 748727007425 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 748727007426 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 748727007427 G1 box; other site 748727007428 putative GEF interaction site [polypeptide binding]; other site 748727007429 GTP/Mg2+ binding site [chemical binding]; other site 748727007430 Switch I region; other site 748727007431 G2 box; other site 748727007432 G3 box; other site 748727007433 Switch II region; other site 748727007434 G4 box; other site 748727007435 G5 box; other site 748727007436 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 748727007437 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 748727007438 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 748727007439 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 748727007440 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727007441 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727007442 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727007443 Walker A/P-loop; other site 748727007444 ATP binding site [chemical binding]; other site 748727007445 Q-loop/lid; other site 748727007446 ABC transporter signature motif; other site 748727007447 Walker B; other site 748727007448 D-loop; other site 748727007449 H-loop/switch region; other site 748727007450 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748727007451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727007452 Walker A/P-loop; other site 748727007453 ATP binding site [chemical binding]; other site 748727007454 Q-loop/lid; other site 748727007455 ABC transporter signature motif; other site 748727007456 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727007457 Walker B; other site 748727007458 D-loop; other site 748727007459 LytTr DNA-binding domain; Region: LytTR; pfam04397 748727007460 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727007461 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 748727007462 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 748727007463 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748727007464 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 748727007465 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 748727007466 Clp amino terminal domain; Region: Clp_N; pfam02861 748727007467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007468 Walker A motif; other site 748727007469 ATP binding site [chemical binding]; other site 748727007470 Walker B motif; other site 748727007471 arginine finger; other site 748727007472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007473 Walker A motif; other site 748727007474 ATP binding site [chemical binding]; other site 748727007475 Walker B motif; other site 748727007476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748727007477 Uncharacterized conserved protein [Function unknown]; Region: COG2127 748727007478 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727007479 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727007480 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727007481 Family description; Region: VCBS; pfam13517 748727007482 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727007483 Cache domain; Region: Cache_1; pfam02743 748727007484 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727007485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727007486 dimer interface [polypeptide binding]; other site 748727007487 putative CheW interface [polypeptide binding]; other site 748727007488 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727007489 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727007490 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 748727007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727007492 putative substrate translocation pore; other site 748727007493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727007494 sequence-specific DNA binding site [nucleotide binding]; other site 748727007495 salt bridge; other site 748727007496 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 748727007497 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727007498 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727007499 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 748727007500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727007501 putative active site [active] 748727007502 heme pocket [chemical binding]; other site 748727007503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007504 Walker A motif; other site 748727007505 ATP binding site [chemical binding]; other site 748727007506 Walker B motif; other site 748727007507 arginine finger; other site 748727007508 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727007509 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 748727007510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727007511 tetramer interface [polypeptide binding]; other site 748727007512 catalytic Zn binding site [ion binding]; other site 748727007513 NADP binding site [chemical binding]; other site 748727007514 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 748727007515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727007516 putative active site [active] 748727007517 heme pocket [chemical binding]; other site 748727007518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727007519 Walker A motif; other site 748727007520 ATP binding site [chemical binding]; other site 748727007521 Walker B motif; other site 748727007522 arginine finger; other site 748727007523 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727007524 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727007525 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 748727007526 putative active site [active] 748727007527 metal binding site [ion binding]; metal-binding site 748727007528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748727007529 metal-binding site [ion binding] 748727007530 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748727007531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748727007532 metal-binding site [ion binding] 748727007533 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748727007534 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748727007535 metal-binding site [ion binding] 748727007536 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 748727007537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727007538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727007539 motif II; other site 748727007540 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 748727007541 putative homodimer interface [polypeptide binding]; other site 748727007542 putative homotetramer interface [polypeptide binding]; other site 748727007543 putative allosteric switch controlling residues; other site 748727007544 putative metal binding site [ion binding]; other site 748727007545 putative homodimer-homodimer interface [polypeptide binding]; other site 748727007546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748727007547 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748727007548 active site 748727007549 motif I; other site 748727007550 motif II; other site 748727007551 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 748727007552 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727007553 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727007554 EDD domain protein, DegV family; Region: DegV; TIGR00762 748727007555 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748727007556 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727007557 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727007558 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 748727007559 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727007560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727007561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727007562 substrate binding pocket [chemical binding]; other site 748727007563 membrane-bound complex binding site; other site 748727007564 hinge residues; other site 748727007565 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748727007566 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748727007567 MOSC domain; Region: MOSC; pfam03473 748727007568 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 748727007569 trimer interface [polypeptide binding]; other site 748727007570 dimer interface [polypeptide binding]; other site 748727007571 putative active site [active] 748727007572 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 748727007573 MPT binding site; other site 748727007574 trimer interface [polypeptide binding]; other site 748727007575 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 748727007576 Sulfatase; Region: Sulfatase; pfam00884 748727007577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727007578 dimerization interface [polypeptide binding]; other site 748727007579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727007580 dimer interface [polypeptide binding]; other site 748727007581 phosphorylation site [posttranslational modification] 748727007582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727007583 ATP binding site [chemical binding]; other site 748727007584 Mg2+ binding site [ion binding]; other site 748727007585 G-X-G motif; other site 748727007586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727007587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727007588 active site 748727007589 phosphorylation site [posttranslational modification] 748727007590 intermolecular recognition site; other site 748727007591 dimerization interface [polypeptide binding]; other site 748727007592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727007593 DNA binding site [nucleotide binding] 748727007594 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 748727007595 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727007596 Walker A/P-loop; other site 748727007597 ATP binding site [chemical binding]; other site 748727007598 Q-loop/lid; other site 748727007599 ABC transporter signature motif; other site 748727007600 Walker B; other site 748727007601 D-loop; other site 748727007602 H-loop/switch region; other site 748727007603 Predicted transcriptional regulators [Transcription]; Region: COG1725 748727007604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727007605 DNA-binding site [nucleotide binding]; DNA binding site 748727007606 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727007607 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727007608 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 748727007609 Putative amidase domain; Region: Amidase_6; pfam12671 748727007610 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 748727007611 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 748727007612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748727007613 active site 748727007614 catalytic tetrad [active] 748727007615 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727007616 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 748727007617 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727007618 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748727007619 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748727007620 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727007621 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727007622 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 748727007623 substrate binding site [chemical binding]; other site 748727007624 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 748727007625 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 748727007626 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 748727007627 catalytic site [active] 748727007628 subunit interface [polypeptide binding]; other site 748727007629 ornithine carbamoyltransferase; Validated; Region: PRK02102 748727007630 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727007631 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727007632 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 748727007633 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 748727007634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727007635 S-adenosylmethionine binding site [chemical binding]; other site 748727007636 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 748727007637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727007638 ATP binding site [chemical binding]; other site 748727007639 putative Mg++ binding site [ion binding]; other site 748727007640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727007641 nucleotide binding region [chemical binding]; other site 748727007642 ATP-binding site [chemical binding]; other site 748727007643 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 748727007644 HRDC domain; Region: HRDC; pfam00570 748727007645 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 748727007646 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 748727007647 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 748727007648 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748727007649 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748727007650 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 748727007651 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 748727007652 citrate lyase, beta subunit; Region: citE; TIGR01588 748727007653 citrate lyase subunit gamma; Provisional; Region: PRK13253 748727007654 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 748727007655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748727007656 active site 748727007657 nucleotide binding site [chemical binding]; other site 748727007658 HIGH motif; other site 748727007659 KMSKS motif; other site 748727007660 Malic enzyme, N-terminal domain; Region: malic; pfam00390 748727007661 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 748727007662 putative NAD(P) binding site [chemical binding]; other site 748727007663 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 748727007664 NMT1/THI5 like; Region: NMT1; pfam09084 748727007665 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 748727007666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727007667 dimer interface [polypeptide binding]; other site 748727007668 conserved gate region; other site 748727007669 putative PBP binding loops; other site 748727007670 ABC-ATPase subunit interface; other site 748727007671 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 748727007672 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 748727007673 Walker A/P-loop; other site 748727007674 ATP binding site [chemical binding]; other site 748727007675 Q-loop/lid; other site 748727007676 ABC transporter signature motif; other site 748727007677 Walker B; other site 748727007678 D-loop; other site 748727007679 H-loop/switch region; other site 748727007680 Putative transcription activator [Transcription]; Region: TenA; COG0819 748727007681 TspO/MBR family; Region: TspO_MBR; pfam03073 748727007682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727007683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727007684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727007685 dimerization interface [polypeptide binding]; other site 748727007686 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 748727007687 molybdopterin cofactor binding site; other site 748727007688 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 748727007689 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 748727007690 molybdopterin cofactor binding site; other site 748727007691 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 748727007692 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 748727007693 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 748727007694 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727007695 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 748727007696 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 748727007697 FAD binding pocket [chemical binding]; other site 748727007698 FAD binding motif [chemical binding]; other site 748727007699 phosphate binding motif [ion binding]; other site 748727007700 beta-alpha-beta structure motif; other site 748727007701 NAD binding pocket [chemical binding]; other site 748727007702 Iron coordination center [ion binding]; other site 748727007703 Stage II sporulation protein; Region: SpoIID; pfam08486 748727007704 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 748727007705 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 748727007706 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727007707 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 748727007708 Prephenate dehydratase; Region: PDT; pfam00800 748727007709 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 748727007710 putative L-Phe binding site [chemical binding]; other site 748727007711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727007712 MarR family; Region: MarR_2; pfam12802 748727007713 Predicted membrane protein [Function unknown]; Region: COG2364 748727007714 hypothetical protein; Provisional; Region: PRK06771 748727007715 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 748727007716 active site 748727007717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727007718 ATP binding site [chemical binding]; other site 748727007719 Mg2+ binding site [ion binding]; other site 748727007720 G-X-G motif; other site 748727007721 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 748727007722 SdpI/YhfL protein family; Region: SdpI; pfam13630 748727007723 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 748727007724 Uncharacterized conserved protein [Function unknown]; Region: COG1359 748727007725 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748727007726 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748727007727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727007728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727007729 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727007730 DNA binding residues [nucleotide binding] 748727007731 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727007732 putative dimer interface [polypeptide binding]; other site 748727007733 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 748727007734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727007735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727007736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727007737 dimerization interface [polypeptide binding]; other site 748727007738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727007739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727007740 dimerization interface [polypeptide binding]; other site 748727007741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727007742 dimer interface [polypeptide binding]; other site 748727007743 phosphorylation site [posttranslational modification] 748727007744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727007745 ATP binding site [chemical binding]; other site 748727007746 Mg2+ binding site [ion binding]; other site 748727007747 G-X-G motif; other site 748727007748 Erythromycin esterase; Region: Erythro_esteras; pfam05139 748727007749 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748727007750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727007751 Walker A/P-loop; other site 748727007752 ATP binding site [chemical binding]; other site 748727007753 Q-loop/lid; other site 748727007754 ABC transporter signature motif; other site 748727007755 Walker B; other site 748727007756 D-loop; other site 748727007757 H-loop/switch region; other site 748727007758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727007759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727007760 active site 748727007761 phosphorylation site [posttranslational modification] 748727007762 intermolecular recognition site; other site 748727007763 dimerization interface [polypeptide binding]; other site 748727007764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727007765 DNA binding site [nucleotide binding] 748727007766 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 748727007767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727007769 active site 748727007770 phosphorylation site [posttranslational modification] 748727007771 intermolecular recognition site; other site 748727007772 dimerization interface [polypeptide binding]; other site 748727007773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727007774 DNA binding site [nucleotide binding] 748727007775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727007776 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 748727007777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727007778 ATP binding site [chemical binding]; other site 748727007779 Mg2+ binding site [ion binding]; other site 748727007780 G-X-G motif; other site 748727007781 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727007782 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727007783 Walker A/P-loop; other site 748727007784 ATP binding site [chemical binding]; other site 748727007785 Q-loop/lid; other site 748727007786 ABC transporter signature motif; other site 748727007787 Walker B; other site 748727007788 D-loop; other site 748727007789 H-loop/switch region; other site 748727007790 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727007791 FtsX-like permease family; Region: FtsX; pfam02687 748727007792 FtsX-like permease family; Region: FtsX; pfam02687 748727007793 6-phosphofructokinase; Provisional; Region: PRK03202 748727007794 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 748727007795 active site 748727007796 ADP/pyrophosphate binding site [chemical binding]; other site 748727007797 dimerization interface [polypeptide binding]; other site 748727007798 allosteric effector site; other site 748727007799 fructose-1,6-bisphosphate binding site; other site 748727007800 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 748727007801 MFS/sugar transport protein; Region: MFS_2; pfam13347 748727007802 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727007803 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 748727007804 NAD(P) binding site [chemical binding]; other site 748727007805 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 748727007806 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748727007807 PYR/PP interface [polypeptide binding]; other site 748727007808 dimer interface [polypeptide binding]; other site 748727007809 TPP binding site [chemical binding]; other site 748727007810 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748727007811 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748727007812 TPP-binding site [chemical binding]; other site 748727007813 dimer interface [polypeptide binding]; other site 748727007814 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 748727007815 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 748727007816 NAD(P) binding site [chemical binding]; other site 748727007817 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 748727007818 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 748727007819 NADP binding site [chemical binding]; other site 748727007820 homodimer interface [polypeptide binding]; other site 748727007821 active site 748727007822 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 748727007823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727007824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727007825 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 748727007826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727007827 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727007828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727007829 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727007830 Walker A/P-loop; other site 748727007831 ATP binding site [chemical binding]; other site 748727007832 Q-loop/lid; other site 748727007833 ABC transporter signature motif; other site 748727007834 Walker B; other site 748727007835 D-loop; other site 748727007836 H-loop/switch region; other site 748727007837 Putative zinc-finger; Region: zf-HC2; pfam13490 748727007838 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 748727007839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727007840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727007841 DNA binding residues [nucleotide binding] 748727007842 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 748727007843 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 748727007844 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 748727007845 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 748727007846 Chloramphenicol acetyltransferase; Region: CAT; smart01059 748727007847 Rubrerythrin [Energy production and conversion]; Region: COG1592 748727007848 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 748727007849 binuclear metal center [ion binding]; other site 748727007850 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 748727007851 iron binding site [ion binding]; other site 748727007852 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 748727007853 active site 748727007854 intersubunit interactions; other site 748727007855 catalytic residue [active] 748727007856 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 748727007857 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 748727007858 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748727007859 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 748727007860 Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960 748727007861 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 748727007862 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 748727007863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748727007864 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 748727007865 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748727007866 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748727007867 Interdomain contacts; other site 748727007868 Cytokine receptor motif; other site 748727007869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748727007870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748727007871 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 748727007872 active site 748727007873 P-loop; other site 748727007874 phosphorylation site [posttranslational modification] 748727007875 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 748727007876 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748727007877 active site 748727007878 phosphorylation site [posttranslational modification] 748727007879 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748727007880 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748727007881 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748727007882 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 748727007883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727007884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727007885 metal binding site [ion binding]; metal-binding site 748727007886 active site 748727007887 I-site; other site 748727007888 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 748727007889 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 748727007890 active site 748727007891 putative substrate binding pocket [chemical binding]; other site 748727007892 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 748727007893 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727007894 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 748727007895 active site 748727007896 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 748727007897 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 748727007898 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 748727007899 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748727007900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727007901 Walker A/P-loop; other site 748727007902 ATP binding site [chemical binding]; other site 748727007903 Q-loop/lid; other site 748727007904 ABC transporter signature motif; other site 748727007905 Walker B; other site 748727007906 D-loop; other site 748727007907 H-loop/switch region; other site 748727007908 TOBE domain; Region: TOBE_2; pfam08402 748727007909 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748727007910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727007911 dimer interface [polypeptide binding]; other site 748727007912 conserved gate region; other site 748727007913 putative PBP binding loops; other site 748727007914 ABC-ATPase subunit interface; other site 748727007915 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 748727007916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727007917 dimer interface [polypeptide binding]; other site 748727007918 conserved gate region; other site 748727007919 putative PBP binding loops; other site 748727007920 ABC-ATPase subunit interface; other site 748727007921 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 748727007922 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748727007923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727007924 catalytic residue [active] 748727007925 4Fe-4S binding domain; Region: Fer4; cl02805 748727007926 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727007927 4Fe-4S binding domain; Region: Fer4; pfam00037 748727007928 Nitroreductase family; Region: Nitroreductase; pfam00881 748727007929 FMN binding site [chemical binding]; other site 748727007930 dimer interface [polypeptide binding]; other site 748727007931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727007932 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 748727007933 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 748727007934 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 748727007935 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 748727007936 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 748727007937 AsnC family; Region: AsnC_trans_reg; pfam01037 748727007938 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727007939 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748727007940 DNA binding residues [nucleotide binding] 748727007941 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 748727007942 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727007943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727007944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727007945 Walker A/P-loop; other site 748727007946 ATP binding site [chemical binding]; other site 748727007947 Q-loop/lid; other site 748727007948 ABC transporter signature motif; other site 748727007949 Walker B; other site 748727007950 D-loop; other site 748727007951 H-loop/switch region; other site 748727007952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748727007953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748727007954 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748727007955 Walker A/P-loop; other site 748727007956 ATP binding site [chemical binding]; other site 748727007957 Q-loop/lid; other site 748727007958 ABC transporter signature motif; other site 748727007959 Walker B; other site 748727007960 D-loop; other site 748727007961 H-loop/switch region; other site 748727007962 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 748727007963 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748727007964 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748727007965 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748727007966 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748727007967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727007968 Walker A/P-loop; other site 748727007969 ATP binding site [chemical binding]; other site 748727007970 Q-loop/lid; other site 748727007971 ABC transporter signature motif; other site 748727007972 Walker B; other site 748727007973 D-loop; other site 748727007974 H-loop/switch region; other site 748727007975 TOBE domain; Region: TOBE_2; pfam08402 748727007976 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748727007977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727007978 dimer interface [polypeptide binding]; other site 748727007979 conserved gate region; other site 748727007980 putative PBP binding loops; other site 748727007981 ABC-ATPase subunit interface; other site 748727007982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727007983 dimer interface [polypeptide binding]; other site 748727007984 conserved gate region; other site 748727007985 putative PBP binding loops; other site 748727007986 ABC-ATPase subunit interface; other site 748727007987 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748727007988 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 748727007989 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 748727007990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748727007991 catalytic core [active] 748727007992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748727007993 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 748727007994 CGNR zinc finger; Region: zf-CGNR; pfam11706 748727007995 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727007996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727007997 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727007998 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748727007999 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 748727008000 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 748727008001 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 748727008002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727008003 MarR family; Region: MarR_2; pfam12802 748727008004 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 748727008005 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748727008006 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748727008007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727008008 active site 748727008009 Family description; Region: DsbD_2; pfam13386 748727008010 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727008011 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748727008012 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727008013 LytTr DNA-binding domain; Region: LytTR; smart00850 748727008014 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748727008015 transmembrane helices; other site 748727008016 Predicted permeases [General function prediction only]; Region: COG0679 748727008017 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 748727008018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727008019 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727008020 DNA binding residues [nucleotide binding] 748727008021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008022 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727008023 Walker A/P-loop; other site 748727008024 ATP binding site [chemical binding]; other site 748727008025 Q-loop/lid; other site 748727008026 ABC transporter signature motif; other site 748727008027 Walker B; other site 748727008028 D-loop; other site 748727008029 H-loop/switch region; other site 748727008030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 748727008031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727008032 dimer interface [polypeptide binding]; other site 748727008033 conserved gate region; other site 748727008034 putative PBP binding loops; other site 748727008035 ABC-ATPase subunit interface; other site 748727008036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 748727008037 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 748727008038 substrate binding pocket [chemical binding]; other site 748727008039 membrane-bound complex binding site; other site 748727008040 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 748727008041 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 748727008042 active site 748727008043 Substrate binding site; other site 748727008044 Mg++ binding site; other site 748727008045 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748727008046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727008047 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 748727008048 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 748727008049 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 748727008050 dimer interface [polypeptide binding]; other site 748727008051 active site 748727008052 metal binding site [ion binding]; metal-binding site 748727008053 short chain dehydrogenase; Provisional; Region: PRK07326 748727008054 classical (c) SDRs; Region: SDR_c; cd05233 748727008055 NAD(P) binding site [chemical binding]; other site 748727008056 active site 748727008057 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 748727008058 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748727008059 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 748727008060 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 748727008061 active site 748727008062 ATP binding site [chemical binding]; other site 748727008063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008064 putative substrate translocation pore; other site 748727008065 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 748727008066 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 748727008067 ribonuclease Z; Reviewed; Region: PRK00055 748727008068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727008069 non-specific DNA binding site [nucleotide binding]; other site 748727008070 salt bridge; other site 748727008071 sequence-specific DNA binding site [nucleotide binding]; other site 748727008072 Biotin operon repressor [Transcription]; Region: BirA; COG1654 748727008073 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 748727008074 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 748727008075 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 748727008076 isoaspartyl dipeptidase; Provisional; Region: PRK10657 748727008077 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727008078 active site 748727008079 Ferredoxin [Energy production and conversion]; Region: COG1146 748727008080 4Fe-4S binding domain; Region: Fer4; cl02805 748727008081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727008082 dimer interface [polypeptide binding]; other site 748727008083 putative CheW interface [polypeptide binding]; other site 748727008084 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 748727008085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727008086 Walker A motif; other site 748727008087 ATP binding site [chemical binding]; other site 748727008088 Walker B motif; other site 748727008089 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 748727008090 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 748727008091 Ligand Binding Site [chemical binding]; other site 748727008092 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 748727008093 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 748727008094 active site 748727008095 dimer interface [polypeptide binding]; other site 748727008096 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748727008097 Ligand Binding Site [chemical binding]; other site 748727008098 Molecular Tunnel; other site 748727008099 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 748727008100 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727008101 NodB motif; other site 748727008102 active site 748727008103 catalytic site [active] 748727008104 Zn binding site [ion binding]; other site 748727008105 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 748727008106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748727008107 active site 748727008108 HIGH motif; other site 748727008109 nucleotide binding site [chemical binding]; other site 748727008110 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 748727008111 KMSKS motif; other site 748727008112 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 748727008113 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 748727008114 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 748727008115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727008116 DNA binding residues [nucleotide binding] 748727008117 dimer interface [polypeptide binding]; other site 748727008118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727008119 S-adenosylmethionine binding site [chemical binding]; other site 748727008120 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 748727008121 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 748727008122 inhibitor-cofactor binding pocket; inhibition site 748727008123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727008124 catalytic residue [active] 748727008125 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 748727008126 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 748727008127 inhibitor-cofactor binding pocket; inhibition site 748727008128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727008129 catalytic residue [active] 748727008130 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 748727008131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727008132 metal binding site [ion binding]; metal-binding site 748727008133 active site 748727008134 I-site; other site 748727008135 Phage integrase family; Region: Phage_integrase; pfam00589 748727008136 active site 748727008137 DNA binding site [nucleotide binding] 748727008138 Int/Topo IB signature motif; other site 748727008139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748727008140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727008141 Coenzyme A binding pocket [chemical binding]; other site 748727008142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727008143 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727008144 Walker A/P-loop; other site 748727008145 ATP binding site [chemical binding]; other site 748727008146 Q-loop/lid; other site 748727008147 ABC transporter signature motif; other site 748727008148 Walker B; other site 748727008149 D-loop; other site 748727008150 H-loop/switch region; other site 748727008151 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 748727008152 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 748727008153 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 748727008154 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 748727008155 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 748727008156 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 748727008157 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 748727008158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008159 Walker A/P-loop; other site 748727008160 ATP binding site [chemical binding]; other site 748727008161 Q-loop/lid; other site 748727008162 ABC transporter signature motif; other site 748727008163 Walker B; other site 748727008164 D-loop; other site 748727008165 H-loop/switch region; other site 748727008166 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727008167 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727008168 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 748727008169 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 748727008170 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 748727008171 Uncharacterized conserved protein [Function unknown]; Region: COG2006 748727008172 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727008173 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727008174 DNA binding residues [nucleotide binding] 748727008175 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 748727008176 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 748727008177 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727008178 active site 748727008179 DNA binding site [nucleotide binding] 748727008180 Int/Topo IB signature motif; other site 748727008181 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 748727008182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727008183 FeS/SAM binding site; other site 748727008184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727008185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727008186 dimerization interface [polypeptide binding]; other site 748727008187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727008188 dimer interface [polypeptide binding]; other site 748727008189 phosphorylation site [posttranslational modification] 748727008190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008191 ATP binding site [chemical binding]; other site 748727008192 Mg2+ binding site [ion binding]; other site 748727008193 G-X-G motif; other site 748727008194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008196 active site 748727008197 phosphorylation site [posttranslational modification] 748727008198 intermolecular recognition site; other site 748727008199 dimerization interface [polypeptide binding]; other site 748727008200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727008201 DNA binding site [nucleotide binding] 748727008202 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727008203 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727008204 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727008205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008206 Walker A/P-loop; other site 748727008207 ATP binding site [chemical binding]; other site 748727008208 Q-loop/lid; other site 748727008209 ABC transporter signature motif; other site 748727008210 Walker B; other site 748727008211 D-loop; other site 748727008212 H-loop/switch region; other site 748727008213 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 748727008214 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 748727008215 Metal-binding active site; metal-binding site 748727008216 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 748727008217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008218 Walker A/P-loop; other site 748727008219 ATP binding site [chemical binding]; other site 748727008220 Q-loop/lid; other site 748727008221 ABC transporter signature motif; other site 748727008222 Walker B; other site 748727008223 D-loop; other site 748727008224 H-loop/switch region; other site 748727008225 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 748727008226 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727008227 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727008228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727008229 MarR family; Region: MarR_2; pfam12802 748727008230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727008231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008232 Walker A/P-loop; other site 748727008233 ATP binding site [chemical binding]; other site 748727008234 Q-loop/lid; other site 748727008235 ABC transporter signature motif; other site 748727008236 Walker B; other site 748727008237 D-loop; other site 748727008238 H-loop/switch region; other site 748727008239 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727008240 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748727008241 Zn binding site [ion binding]; other site 748727008242 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727008243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727008244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008245 active site 748727008246 phosphorylation site [posttranslational modification] 748727008247 intermolecular recognition site; other site 748727008248 dimerization interface [polypeptide binding]; other site 748727008249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727008250 DNA binding site [nucleotide binding] 748727008251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727008252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727008253 phosphorylation site [posttranslational modification] 748727008254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008255 ATP binding site [chemical binding]; other site 748727008256 Mg2+ binding site [ion binding]; other site 748727008257 G-X-G motif; other site 748727008258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727008259 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727008260 Walker A/P-loop; other site 748727008261 ATP binding site [chemical binding]; other site 748727008262 Q-loop/lid; other site 748727008263 ABC transporter signature motif; other site 748727008264 Walker B; other site 748727008265 D-loop; other site 748727008266 H-loop/switch region; other site 748727008267 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748727008268 FtsX-like permease family; Region: FtsX; pfam02687 748727008269 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748727008270 FtsX-like permease family; Region: FtsX; pfam02687 748727008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727008272 Coenzyme A binding pocket [chemical binding]; other site 748727008273 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 748727008274 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 748727008275 hybrid cluster protein; Provisional; Region: PRK05290 748727008276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727008277 ACS interaction site; other site 748727008278 CODH interaction site; other site 748727008279 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 748727008280 hybrid metal cluster; other site 748727008281 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 748727008282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727008283 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 748727008284 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 748727008285 active site 748727008286 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 748727008287 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748727008288 catalytic residues [active] 748727008289 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 748727008290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727008291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727008292 BCCT family transporter; Region: BCCT; pfam02028 748727008293 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 748727008294 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 748727008295 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 748727008296 Predicted amidohydrolase [General function prediction only]; Region: COG0388 748727008297 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 748727008298 dimer interface [polypeptide binding]; other site 748727008299 active site 748727008300 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 748727008301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727008302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727008303 metal binding site [ion binding]; metal-binding site 748727008304 active site 748727008305 I-site; other site 748727008306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727008307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727008308 non-specific DNA binding site [nucleotide binding]; other site 748727008309 salt bridge; other site 748727008310 sequence-specific DNA binding site [nucleotide binding]; other site 748727008311 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 748727008312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748727008313 YoaP-like; Region: YoaP; pfam14268 748727008314 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008315 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 748727008316 catalytic core [active] 748727008317 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 748727008318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727008319 non-specific DNA binding site [nucleotide binding]; other site 748727008320 salt bridge; other site 748727008321 sequence-specific DNA binding site [nucleotide binding]; other site 748727008322 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 748727008323 RNA polymerase factor sigma-70; Validated; Region: PRK06811 748727008324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727008325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727008326 DNA binding residues [nucleotide binding] 748727008327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 748727008328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008329 ATP binding site [chemical binding]; other site 748727008330 Mg2+ binding site [ion binding]; other site 748727008331 G-X-G motif; other site 748727008332 Accessory gene regulator B; Region: AgrB; pfam04647 748727008333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008334 H+ Antiporter protein; Region: 2A0121; TIGR00900 748727008335 putative substrate translocation pore; other site 748727008336 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727008337 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 748727008338 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 748727008339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727008340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727008341 homodimer interface [polypeptide binding]; other site 748727008342 catalytic residue [active] 748727008343 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727008344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727008345 substrate binding pocket [chemical binding]; other site 748727008346 membrane-bound complex binding site; other site 748727008347 hinge residues; other site 748727008348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727008349 dimer interface [polypeptide binding]; other site 748727008350 conserved gate region; other site 748727008351 putative PBP binding loops; other site 748727008352 ABC-ATPase subunit interface; other site 748727008353 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748727008354 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748727008355 Walker A/P-loop; other site 748727008356 ATP binding site [chemical binding]; other site 748727008357 Q-loop/lid; other site 748727008358 ABC transporter signature motif; other site 748727008359 Walker B; other site 748727008360 D-loop; other site 748727008361 H-loop/switch region; other site 748727008362 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 748727008363 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 748727008364 active site pocket [active] 748727008365 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 748727008366 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 748727008367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727008368 dimer interface [polypeptide binding]; other site 748727008369 conserved gate region; other site 748727008370 putative PBP binding loops; other site 748727008371 ABC-ATPase subunit interface; other site 748727008372 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 748727008373 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 748727008374 Walker A/P-loop; other site 748727008375 ATP binding site [chemical binding]; other site 748727008376 Q-loop/lid; other site 748727008377 ABC transporter signature motif; other site 748727008378 Walker B; other site 748727008379 D-loop; other site 748727008380 H-loop/switch region; other site 748727008381 NIL domain; Region: NIL; cl09633 748727008382 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 748727008383 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 748727008384 G1 box; other site 748727008385 putative GEF interaction site [polypeptide binding]; other site 748727008386 GTP/Mg2+ binding site [chemical binding]; other site 748727008387 Switch I region; other site 748727008388 G2 box; other site 748727008389 G3 box; other site 748727008390 Switch II region; other site 748727008391 G4 box; other site 748727008392 G5 box; other site 748727008393 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 748727008394 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 748727008395 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 748727008396 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 748727008397 selenocysteine synthase; Provisional; Region: PRK04311 748727008398 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 748727008399 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 748727008400 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727008401 catalytic residue [active] 748727008402 catalytic residue [active] 748727008403 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 748727008404 dimerization interface [polypeptide binding]; other site 748727008405 putative ATP binding site [chemical binding]; other site 748727008406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748727008407 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748727008408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727008409 catalytic residue [active] 748727008410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727008411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727008412 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 748727008413 putative dimerization interface [polypeptide binding]; other site 748727008414 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 748727008415 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 748727008416 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 748727008417 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 748727008418 active site 748727008419 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 748727008420 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748727008421 catalytic residues [active] 748727008422 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 748727008423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727008424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727008425 BCCT family transporter; Region: BCCT; pfam02028 748727008426 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 748727008427 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 748727008428 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 748727008429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727008430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727008431 Predicted permease; Region: DUF318; cl17795 748727008432 AAA domain; Region: AAA_23; pfam13476 748727008433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008434 Walker A/P-loop; other site 748727008435 ATP binding site [chemical binding]; other site 748727008436 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 748727008437 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 748727008438 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 748727008439 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 748727008440 Protein of unknown function (DUF917); Region: DUF917; pfam06032 748727008441 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 748727008442 putative FMN binding site [chemical binding]; other site 748727008443 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 748727008444 Na binding site [ion binding]; other site 748727008445 Predicted amidohydrolase [General function prediction only]; Region: COG0388 748727008446 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 748727008447 active site 748727008448 catalytic triad [active] 748727008449 dimer interface [polypeptide binding]; other site 748727008450 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 748727008451 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727008452 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 748727008453 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727008454 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 748727008455 carbamate kinase; Reviewed; Region: PRK12686 748727008456 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727008457 putative substrate binding site [chemical binding]; other site 748727008458 nucleotide binding site [chemical binding]; other site 748727008459 nucleotide binding site [chemical binding]; other site 748727008460 homodimer interface [polypeptide binding]; other site 748727008461 ornithine carbamoyltransferase; Provisional; Region: PRK04284 748727008462 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727008463 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727008464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727008465 dimer interface [polypeptide binding]; other site 748727008466 putative CheW interface [polypeptide binding]; other site 748727008467 Cache domain; Region: Cache_1; pfam02743 748727008468 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727008469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727008470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008471 Response regulator receiver domain; Region: Response_reg; pfam00072 748727008472 active site 748727008473 phosphorylation site [posttranslational modification] 748727008474 intermolecular recognition site; other site 748727008475 dimerization interface [polypeptide binding]; other site 748727008476 YcbB domain; Region: YcbB; pfam08664 748727008477 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748727008478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008479 Response regulator receiver domain; Region: Response_reg; pfam00072 748727008480 active site 748727008481 phosphorylation site [posttranslational modification] 748727008482 intermolecular recognition site; other site 748727008483 dimerization interface [polypeptide binding]; other site 748727008484 YcbB domain; Region: YcbB; pfam08664 748727008485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008486 ATP binding site [chemical binding]; other site 748727008487 Mg2+ binding site [ion binding]; other site 748727008488 G-X-G motif; other site 748727008489 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 748727008490 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727008491 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727008492 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 748727008493 active site 748727008494 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 748727008495 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 748727008496 galactarate dehydratase; Region: galactar-dH20; TIGR03248 748727008497 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 748727008498 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 748727008499 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 748727008500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008501 D-galactonate transporter; Region: 2A0114; TIGR00893 748727008502 putative substrate translocation pore; other site 748727008503 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 748727008504 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 748727008505 active site 748727008506 tetramer interface [polypeptide binding]; other site 748727008507 GntP family permease; Region: GntP_permease; pfam02447 748727008508 fructuronate transporter; Provisional; Region: PRK10034; cl15264 748727008509 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 748727008510 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 748727008511 active site 748727008512 tetramer interface [polypeptide binding]; other site 748727008513 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 748727008514 metal binding site [ion binding]; metal-binding site 748727008515 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748727008516 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 748727008517 transmembrane helices; other site 748727008518 spermidine synthase; Provisional; Region: PRK00811 748727008519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727008520 S-adenosylmethionine binding site [chemical binding]; other site 748727008521 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748727008522 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748727008523 active site 748727008524 catalytic tetrad [active] 748727008525 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 748727008526 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 748727008527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727008528 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 748727008529 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 748727008530 inhibitor site; inhibition site 748727008531 active site 748727008532 dimer interface [polypeptide binding]; other site 748727008533 catalytic residue [active] 748727008534 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 748727008535 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 748727008536 adenosine deaminase; Provisional; Region: PRK09358 748727008537 active site 748727008538 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727008539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727008540 metal binding site [ion binding]; metal-binding site 748727008541 active site 748727008542 I-site; other site 748727008543 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 748727008544 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 748727008545 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 748727008546 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 748727008547 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 748727008548 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 748727008549 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 748727008550 Ligand Binding Site [chemical binding]; other site 748727008551 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748727008552 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748727008553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727008554 catalytic residue [active] 748727008555 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727008556 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727008557 NodB motif; other site 748727008558 active site 748727008559 catalytic site [active] 748727008560 Zn binding site [ion binding]; other site 748727008561 A short protein domain of unknown function; Region: IDEAL; smart00914 748727008562 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 748727008563 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 748727008564 Part of AAA domain; Region: AAA_19; pfam13245 748727008565 Family description; Region: UvrD_C_2; pfam13538 748727008566 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 748727008567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727008568 S-adenosylmethionine binding site [chemical binding]; other site 748727008569 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 748727008570 Domain of unknown function DUF21; Region: DUF21; pfam01595 748727008571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 748727008572 Transporter associated domain; Region: CorC_HlyC; pfam03471 748727008573 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 748727008574 Accessory gene regulator B; Region: AgrB; pfam04647 748727008575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 748727008576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008577 ATP binding site [chemical binding]; other site 748727008578 Mg2+ binding site [ion binding]; other site 748727008579 G-X-G motif; other site 748727008580 Staphylococcal AgrD protein; Region: AgrD; cl05477 748727008581 potential frameshift: common BLAST hit: gi|153953446|ref|YP_001394211.1| signal transduction protein 748727008582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727008583 active site 748727008584 I-site; other site 748727008585 metal binding site [ion binding]; metal-binding site 748727008586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727008587 Sensory domain found in PocR; Region: PocR; pfam10114 748727008588 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 748727008589 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 748727008590 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 748727008591 RNA binding site [nucleotide binding]; other site 748727008592 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 748727008593 RNA binding site [nucleotide binding]; other site 748727008594 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 748727008595 RNA binding site [nucleotide binding]; other site 748727008596 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 748727008597 RNA binding site [nucleotide binding]; other site 748727008598 domain interface; other site 748727008599 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 748727008600 putative active site pocket [active] 748727008601 cleavage site 748727008602 Predicted membrane protein [Function unknown]; Region: COG4684 748727008603 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748727008604 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727008605 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 748727008606 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727008607 Walker A/P-loop; other site 748727008608 ATP binding site [chemical binding]; other site 748727008609 Q-loop/lid; other site 748727008610 ABC transporter signature motif; other site 748727008611 Walker B; other site 748727008612 D-loop; other site 748727008613 H-loop/switch region; other site 748727008614 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 748727008615 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008616 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008617 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008618 Protein of unknown function (DUF503); Region: DUF503; pfam04456 748727008619 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 748727008620 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 748727008621 nickel binding site [ion binding]; other site 748727008622 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 748727008623 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 748727008624 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 748727008625 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 748727008626 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 748727008627 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 748727008628 substrate binding pocket [chemical binding]; other site 748727008629 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 748727008630 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748727008631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008632 D-galactonate transporter; Region: 2A0114; TIGR00893 748727008633 putative substrate translocation pore; other site 748727008634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727008636 putative substrate translocation pore; other site 748727008637 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 748727008638 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727008639 active site 748727008640 FMN binding site [chemical binding]; other site 748727008641 substrate binding site [chemical binding]; other site 748727008642 putative catalytic residue [active] 748727008643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727008644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727008645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727008646 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 748727008647 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727008648 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727008649 active site 748727008650 FMN binding site [chemical binding]; other site 748727008651 substrate binding site [chemical binding]; other site 748727008652 putative catalytic residue [active] 748727008653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727008654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727008655 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 748727008656 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 748727008657 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 748727008658 shikimate binding site; other site 748727008659 NAD(P) binding site [chemical binding]; other site 748727008660 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 748727008661 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 748727008662 active site 748727008663 catalytic residue [active] 748727008664 dimer interface [polypeptide binding]; other site 748727008665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727008666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727008667 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 748727008668 putative dimerization interface [polypeptide binding]; other site 748727008669 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 748727008670 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 748727008671 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748727008672 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 748727008673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748727008674 Type II/IV secretion system protein; Region: T2SE; pfam00437 748727008675 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 748727008676 ATP binding site [chemical binding]; other site 748727008677 Walker A motif; other site 748727008678 hexamer interface [polypeptide binding]; other site 748727008679 Walker B motif; other site 748727008680 Response regulator receiver domain; Region: Response_reg; pfam00072 748727008681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008682 active site 748727008683 phosphorylation site [posttranslational modification] 748727008684 intermolecular recognition site; other site 748727008685 dimerization interface [polypeptide binding]; other site 748727008686 AAA domain; Region: AAA_31; pfam13614 748727008687 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 748727008688 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 748727008689 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 748727008690 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 748727008691 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748727008692 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 748727008693 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 748727008694 TadE-like protein; Region: TadE; pfam07811 748727008695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 748727008696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008697 active site 748727008698 phosphorylation site [posttranslational modification] 748727008699 intermolecular recognition site; other site 748727008700 dimerization interface [polypeptide binding]; other site 748727008701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748727008702 DNA binding residues [nucleotide binding] 748727008703 dimerization interface [polypeptide binding]; other site 748727008704 Sensor protein DegS; Region: DegS; pfam05384 748727008705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 748727008706 Histidine kinase; Region: HisKA_3; pfam07730 748727008707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008708 ATP binding site [chemical binding]; other site 748727008709 Mg2+ binding site [ion binding]; other site 748727008710 G-X-G motif; other site 748727008711 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 748727008712 Rubrerythrin [Energy production and conversion]; Region: COG1592 748727008713 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 748727008714 diiron binding motif [ion binding]; other site 748727008715 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 748727008716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748727008717 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 748727008718 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748727008719 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748727008720 Walker A/P-loop; other site 748727008721 ATP binding site [chemical binding]; other site 748727008722 Q-loop/lid; other site 748727008723 ABC transporter signature motif; other site 748727008724 Walker B; other site 748727008725 D-loop; other site 748727008726 H-loop/switch region; other site 748727008727 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748727008728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727008729 dimer interface [polypeptide binding]; other site 748727008730 conserved gate region; other site 748727008731 putative PBP binding loops; other site 748727008732 ABC-ATPase subunit interface; other site 748727008733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727008734 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727008735 substrate binding pocket [chemical binding]; other site 748727008736 membrane-bound complex binding site; other site 748727008737 hinge residues; other site 748727008738 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 748727008739 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 748727008740 FOG: CBS domain [General function prediction only]; Region: COG0517 748727008741 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 748727008742 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748727008743 active site 748727008744 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 748727008745 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 748727008746 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 748727008747 putative active site [active] 748727008748 catalytic site [active] 748727008749 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 748727008750 putative active site [active] 748727008751 catalytic site [active] 748727008752 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 748727008753 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 748727008754 active site 748727008755 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 748727008756 substrate binding site [chemical binding]; other site 748727008757 metal binding site [ion binding]; metal-binding site 748727008758 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748727008759 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727008760 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748727008761 Uncharacterized conserved protein [Function unknown]; Region: COG3391 748727008762 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 748727008763 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 748727008764 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748727008765 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748727008766 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 748727008767 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 748727008768 ADP binding site [chemical binding]; other site 748727008769 magnesium binding site [ion binding]; other site 748727008770 putative shikimate binding site; other site 748727008771 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 748727008772 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 748727008773 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 748727008774 shikimate binding site; other site 748727008775 NAD(P) binding site [chemical binding]; other site 748727008776 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 748727008777 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 748727008778 Prephenate dehydratase; Region: PDT; pfam00800 748727008779 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 748727008780 putative L-Phe binding site [chemical binding]; other site 748727008781 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 748727008782 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 748727008783 Tetramer interface [polypeptide binding]; other site 748727008784 active site 748727008785 FMN-binding site [chemical binding]; other site 748727008786 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 748727008787 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 748727008788 hinge; other site 748727008789 active site 748727008790 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 748727008791 active site 748727008792 dimer interface [polypeptide binding]; other site 748727008793 metal binding site [ion binding]; metal-binding site 748727008794 prephenate dehydrogenase; Validated; Region: PRK08507 748727008795 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 748727008796 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 748727008797 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 748727008798 CHAP domain; Region: CHAP; cl17642 748727008799 Bacterial SH3 domain; Region: SH3_3; pfam08239 748727008800 Bacterial SH3 domain; Region: SH3_3; cl17532 748727008801 Bacterial SH3 domain; Region: SH3_3; pfam08239 748727008802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 748727008803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008804 active site 748727008805 phosphorylation site [posttranslational modification] 748727008806 intermolecular recognition site; other site 748727008807 dimerization interface [polypeptide binding]; other site 748727008808 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 748727008809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748727008810 NAD(P) binding site [chemical binding]; other site 748727008811 active site 748727008812 Cache domain; Region: Cache_1; pfam02743 748727008813 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727008814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727008815 dimerization interface [polypeptide binding]; other site 748727008816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727008817 dimer interface [polypeptide binding]; other site 748727008818 putative CheW interface [polypeptide binding]; other site 748727008819 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 748727008820 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 748727008821 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727008822 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727008823 Zn2+ binding site [ion binding]; other site 748727008824 Mg2+ binding site [ion binding]; other site 748727008825 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 748727008826 Sensory domain found in PocR; Region: PocR; pfam10114 748727008827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727008828 dimer interface [polypeptide binding]; other site 748727008829 putative CheW interface [polypeptide binding]; other site 748727008830 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 748727008831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727008832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727008833 Coenzyme A binding pocket [chemical binding]; other site 748727008834 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 748727008835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727008836 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 748727008837 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748727008838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727008839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727008840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727008841 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 748727008842 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 748727008843 dimer interface [polypeptide binding]; other site 748727008844 PYR/PP interface [polypeptide binding]; other site 748727008845 TPP binding site [chemical binding]; other site 748727008846 substrate binding site [chemical binding]; other site 748727008847 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 748727008848 Domain of unknown function; Region: EKR; pfam10371 748727008849 4Fe-4S binding domain; Region: Fer4_6; pfam12837 748727008850 4Fe-4S binding domain; Region: Fer4; pfam00037 748727008851 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 748727008852 TPP-binding site [chemical binding]; other site 748727008853 dimer interface [polypeptide binding]; other site 748727008854 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 748727008855 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748727008856 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 748727008857 Interdomain contacts; other site 748727008858 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 748727008859 Predicted ATPase [General function prediction only]; Region: COG3910 748727008860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727008861 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 748727008862 Walker A/P-loop; other site 748727008863 Walker A/P-loop; other site 748727008864 ATP binding site [chemical binding]; other site 748727008865 ATP binding site [chemical binding]; other site 748727008866 Q-loop/lid; other site 748727008867 ABC transporter signature motif; other site 748727008868 Walker B; other site 748727008869 D-loop; other site 748727008870 H-loop/switch region; other site 748727008871 Transcriptional regulator [Transcription]; Region: IclR; COG1414 748727008872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727008873 putative DNA binding site [nucleotide binding]; other site 748727008874 putative Zn2+ binding site [ion binding]; other site 748727008875 Bacterial transcriptional regulator; Region: IclR; pfam01614 748727008876 aspartate aminotransferase; Provisional; Region: PRK06348 748727008877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727008878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727008879 homodimer interface [polypeptide binding]; other site 748727008880 catalytic residue [active] 748727008881 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727008882 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727008883 Nitroreductase family; Region: Nitroreductase; pfam00881 748727008884 FMN binding site [chemical binding]; other site 748727008885 dimer interface [polypeptide binding]; other site 748727008886 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 748727008887 active site 748727008888 catalytic site [active] 748727008889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727008890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727008891 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727008892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727008893 DNA-binding site [nucleotide binding]; DNA binding site 748727008894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727008895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727008896 homodimer interface [polypeptide binding]; other site 748727008897 catalytic residue [active] 748727008898 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 748727008899 aspartate racemase; Region: asp_race; TIGR00035 748727008900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727008901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727008903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727008904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727008905 transcription termination factor Rho; Provisional; Region: rho; PRK09376 748727008906 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748727008907 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 748727008908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727008909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727008910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748727008911 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 748727008912 active site residue [active] 748727008913 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 748727008914 CPxP motif; other site 748727008915 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 748727008916 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727008917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727008918 S-adenosylmethionine binding site [chemical binding]; other site 748727008919 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 748727008920 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 748727008921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727008922 dimerization interface [polypeptide binding]; other site 748727008923 putative DNA binding site [nucleotide binding]; other site 748727008924 putative Zn2+ binding site [ion binding]; other site 748727008925 Predicted permeases [General function prediction only]; Region: COG0701 748727008926 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 748727008927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727008928 dimerization interface [polypeptide binding]; other site 748727008929 putative DNA binding site [nucleotide binding]; other site 748727008930 putative Zn2+ binding site [ion binding]; other site 748727008931 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748727008932 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 748727008933 ligand binding site [chemical binding]; other site 748727008934 flexible hinge region; other site 748727008935 putative switch regulator; other site 748727008936 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 748727008937 non-specific DNA interactions [nucleotide binding]; other site 748727008938 DNA binding site [nucleotide binding] 748727008939 sequence specific DNA binding site [nucleotide binding]; other site 748727008940 putative cAMP binding site [chemical binding]; other site 748727008941 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727008942 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727008943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727008944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727008945 active site 748727008946 phosphorylation site [posttranslational modification] 748727008947 intermolecular recognition site; other site 748727008948 dimerization interface [polypeptide binding]; other site 748727008949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727008950 DNA binding site [nucleotide binding] 748727008951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 748727008952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727008953 dimerization interface [polypeptide binding]; other site 748727008954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727008955 dimer interface [polypeptide binding]; other site 748727008956 phosphorylation site [posttranslational modification] 748727008957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727008958 ATP binding site [chemical binding]; other site 748727008959 Mg2+ binding site [ion binding]; other site 748727008960 G-X-G motif; other site 748727008961 Short C-terminal domain; Region: SHOCT; pfam09851 748727008962 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727008963 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748727008964 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727008965 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748727008966 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748727008967 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748727008968 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748727008969 active site 748727008970 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 748727008971 active site 748727008972 catalytic triad [active] 748727008973 oxyanion hole [active] 748727008974 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 748727008975 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 748727008976 Peptidase family M50; Region: Peptidase_M50; pfam02163 748727008977 active site 748727008978 putative substrate binding region [chemical binding]; other site 748727008979 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 748727008980 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 748727008981 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 748727008982 putative active site [active] 748727008983 PhoH-like protein; Region: PhoH; pfam02562 748727008984 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727008985 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008986 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008987 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727008988 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727008989 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727008990 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 748727008991 active site 748727008992 oxyanion hole [active] 748727008993 catalytic triad [active] 748727008994 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 748727008995 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 748727008996 E-class dimer interface [polypeptide binding]; other site 748727008997 P-class dimer interface [polypeptide binding]; other site 748727008998 active site 748727008999 Cu2+ binding site [ion binding]; other site 748727009000 Zn2+ binding site [ion binding]; other site 748727009001 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 748727009002 Small acid-soluble spore protein H family; Region: SspH; cl06949 748727009003 short chain dehydrogenase; Provisional; Region: PRK06701 748727009004 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 748727009005 NAD binding site [chemical binding]; other site 748727009006 metal binding site [ion binding]; metal-binding site 748727009007 active site 748727009008 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727009009 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 748727009010 putative active site [active] 748727009011 putative FMN binding site [chemical binding]; other site 748727009012 putative substrate binding site [chemical binding]; other site 748727009013 putative catalytic residue [active] 748727009014 putative 4Fe-4S cluster binding site [ion binding]; other site 748727009015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727009016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727009017 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727009018 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727009019 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 748727009020 PrcB C-terminal; Region: PrcB_C; pfam14343 748727009021 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 748727009022 RNA polymerase sigma factor; Provisional; Region: PRK11924 748727009023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727009024 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748727009025 DNA binding residues [nucleotide binding] 748727009026 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009027 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009028 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009029 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 748727009030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727009031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727009032 active site 748727009033 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 748727009034 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 748727009035 nucleoside/Zn binding site; other site 748727009036 dimer interface [polypeptide binding]; other site 748727009037 catalytic motif [active] 748727009038 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 748727009039 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 748727009040 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748727009041 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748727009042 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748727009043 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748727009044 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748727009045 peptidase; Reviewed; Region: PRK13004 748727009046 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 748727009047 putative metal binding site [ion binding]; other site 748727009048 putative dimer interface [polypeptide binding]; other site 748727009049 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 748727009050 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 748727009051 active site 748727009052 putative substrate binding pocket [chemical binding]; other site 748727009053 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727009054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727009055 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748727009056 TM-ABC transporter signature motif; other site 748727009057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727009058 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748727009059 TM-ABC transporter signature motif; other site 748727009060 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 748727009061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748727009062 Walker A/P-loop; other site 748727009063 ATP binding site [chemical binding]; other site 748727009064 Q-loop/lid; other site 748727009065 ABC transporter signature motif; other site 748727009066 Walker B; other site 748727009067 D-loop; other site 748727009068 H-loop/switch region; other site 748727009069 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748727009070 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 748727009071 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 748727009072 putative ligand binding site [chemical binding]; other site 748727009073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 748727009074 YheO-like PAS domain; Region: PAS_6; pfam08348 748727009075 HTH domain; Region: HTH_22; pfam13309 748727009076 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 748727009077 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 748727009078 active site 748727009079 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727009080 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 748727009081 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 748727009082 active site 748727009083 Response regulator receiver domain; Region: Response_reg; pfam00072 748727009084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009085 active site 748727009086 phosphorylation site [posttranslational modification] 748727009087 intermolecular recognition site; other site 748727009088 dimerization interface [polypeptide binding]; other site 748727009089 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 748727009090 GAF domain; Region: GAF; pfam01590 748727009091 PAS domain; Region: PAS_9; pfam13426 748727009092 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 748727009093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727009094 dimer interface [polypeptide binding]; other site 748727009095 phosphorylation site [posttranslational modification] 748727009096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727009097 ATP binding site [chemical binding]; other site 748727009098 Mg2+ binding site [ion binding]; other site 748727009099 G-X-G motif; other site 748727009100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 748727009101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009102 active site 748727009103 phosphorylation site [posttranslational modification] 748727009104 intermolecular recognition site; other site 748727009105 dimerization interface [polypeptide binding]; other site 748727009106 Response regulator receiver domain; Region: Response_reg; pfam00072 748727009107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009108 active site 748727009109 phosphorylation site [posttranslational modification] 748727009110 intermolecular recognition site; other site 748727009111 dimerization interface [polypeptide binding]; other site 748727009112 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 748727009113 putative binding surface; other site 748727009114 active site 748727009115 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727009116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727009117 Zn2+ binding site [ion binding]; other site 748727009118 Mg2+ binding site [ion binding]; other site 748727009119 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727009120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009121 active site 748727009122 phosphorylation site [posttranslational modification] 748727009123 intermolecular recognition site; other site 748727009124 dimerization interface [polypeptide binding]; other site 748727009125 LytTr DNA-binding domain; Region: LytTR; pfam04397 748727009126 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 748727009127 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 748727009128 ATP binding site [chemical binding]; other site 748727009129 Mg2+ binding site [ion binding]; other site 748727009130 G-X-G motif; other site 748727009131 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 748727009132 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 748727009133 NAD binding site [chemical binding]; other site 748727009134 ligand binding site [chemical binding]; other site 748727009135 catalytic site [active] 748727009136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727009137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727009138 dimer interface [polypeptide binding]; other site 748727009139 phosphorylation site [posttranslational modification] 748727009140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727009141 ATP binding site [chemical binding]; other site 748727009142 Mg2+ binding site [ion binding]; other site 748727009143 G-X-G motif; other site 748727009144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727009145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009146 active site 748727009147 phosphorylation site [posttranslational modification] 748727009148 intermolecular recognition site; other site 748727009149 dimerization interface [polypeptide binding]; other site 748727009150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727009151 DNA binding site [nucleotide binding] 748727009152 FtsX-like permease family; Region: FtsX; pfam02687 748727009153 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727009154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727009155 Walker A/P-loop; other site 748727009156 ATP binding site [chemical binding]; other site 748727009157 Q-loop/lid; other site 748727009158 ABC transporter signature motif; other site 748727009159 Walker B; other site 748727009160 D-loop; other site 748727009161 H-loop/switch region; other site 748727009162 Part of AAA domain; Region: AAA_19; pfam13245 748727009163 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 748727009164 Family description; Region: UvrD_C_2; pfam13538 748727009165 AAA ATPase domain; Region: AAA_15; pfam13175 748727009166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727009167 Walker A/P-loop; other site 748727009168 ATP binding site [chemical binding]; other site 748727009169 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 748727009170 putative active site [active] 748727009171 putative metal-binding site [ion binding]; other site 748727009172 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 748727009173 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727009174 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727009175 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727009176 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 748727009177 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748727009178 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748727009179 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727009180 L-aspartate oxidase; Provisional; Region: PRK06175 748727009181 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 748727009182 Predicted oxidoreductase [General function prediction only]; Region: COG3573 748727009183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727009184 catalytic loop [active] 748727009185 iron binding site [ion binding]; other site 748727009186 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 748727009187 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727009188 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 748727009189 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 748727009190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727009191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727009192 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 748727009193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727009194 FeS/SAM binding site; other site 748727009195 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 748727009196 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 748727009197 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 748727009198 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 748727009199 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009200 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 748727009201 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009202 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009203 Lamin Tail Domain; Region: LTD; pfam00932 748727009204 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 748727009205 Phage Tail Collar Domain; Region: Collar; pfam07484 748727009206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748727009207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727009208 Coenzyme A binding pocket [chemical binding]; other site 748727009209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727009210 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 748727009211 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 748727009212 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 748727009213 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 748727009214 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727009215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009216 dimer interface [polypeptide binding]; other site 748727009217 putative CheW interface [polypeptide binding]; other site 748727009218 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727009219 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 748727009220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727009221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727009222 Cache domain; Region: Cache_1; pfam02743 748727009223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009224 dimer interface [polypeptide binding]; other site 748727009225 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 748727009226 putative CheW interface [polypeptide binding]; other site 748727009227 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 748727009228 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 748727009229 PrpF protein; Region: PrpF; pfam04303 748727009230 aconitate hydratase; Validated; Region: PRK07229 748727009231 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 748727009232 substrate binding site [chemical binding]; other site 748727009233 ligand binding site [chemical binding]; other site 748727009234 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 748727009235 substrate binding site [chemical binding]; other site 748727009236 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 748727009237 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 748727009238 citrate lyase, beta subunit; Region: citE; TIGR01588 748727009239 citrate lyase subunit gamma; Provisional; Region: PRK13253 748727009240 Malic enzyme, N-terminal domain; Region: malic; pfam00390 748727009241 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 748727009242 putative NAD(P) binding site [chemical binding]; other site 748727009243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727009244 DNA-binding site [nucleotide binding]; DNA binding site 748727009245 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 748727009246 FCD domain; Region: FCD; pfam07729 748727009247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009248 putative substrate translocation pore; other site 748727009249 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 748727009250 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 748727009251 active site 748727009252 putative substrate binding pocket [chemical binding]; other site 748727009253 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 748727009254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748727009255 active site 748727009256 catalytic tetrad [active] 748727009257 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 748727009258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727009259 Coenzyme A binding pocket [chemical binding]; other site 748727009260 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727009261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009262 putative CheW interface [polypeptide binding]; other site 748727009263 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727009264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009265 dimer interface [polypeptide binding]; other site 748727009266 putative CheW interface [polypeptide binding]; other site 748727009267 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 748727009268 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 748727009269 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 748727009270 YoaP-like; Region: YoaP; pfam14268 748727009271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009272 dimer interface [polypeptide binding]; other site 748727009273 putative CheW interface [polypeptide binding]; other site 748727009274 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 748727009275 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 748727009276 putative ligand binding site [chemical binding]; other site 748727009277 putative NAD binding site [chemical binding]; other site 748727009278 putative catalytic site [active] 748727009279 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 748727009280 L-serine binding site [chemical binding]; other site 748727009281 ACT domain interface; other site 748727009282 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748727009283 synthetase active site [active] 748727009284 NTP binding site [chemical binding]; other site 748727009285 metal binding site [ion binding]; metal-binding site 748727009286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727009287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009288 active site 748727009289 phosphorylation site [posttranslational modification] 748727009290 intermolecular recognition site; other site 748727009291 dimerization interface [polypeptide binding]; other site 748727009292 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727009293 DNA binding site [nucleotide binding] 748727009294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727009295 dimer interface [polypeptide binding]; other site 748727009296 phosphorylation site [posttranslational modification] 748727009297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727009298 ATP binding site [chemical binding]; other site 748727009299 Mg2+ binding site [ion binding]; other site 748727009300 G-X-G motif; other site 748727009301 PAS domain; Region: PAS_9; pfam13426 748727009302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727009303 PAS domain; Region: PAS_9; pfam13426 748727009304 putative active site [active] 748727009305 heme pocket [chemical binding]; other site 748727009306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727009307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727009308 metal binding site [ion binding]; metal-binding site 748727009309 active site 748727009310 I-site; other site 748727009311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727009312 Domain of unknown function (DUF336); Region: DUF336; cl01249 748727009313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727009314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727009315 metal binding site [ion binding]; metal-binding site 748727009316 active site 748727009317 I-site; other site 748727009318 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 748727009319 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 748727009320 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 748727009321 generic binding surface II; other site 748727009322 generic binding surface I; other site 748727009323 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748727009324 active site 748727009325 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748727009326 active site 748727009327 catalytic site [active] 748727009328 substrate binding site [chemical binding]; other site 748727009329 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 748727009330 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 748727009331 conserved cys residue [active] 748727009332 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727009333 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 748727009334 active site 748727009335 metal binding site [ion binding]; metal-binding site 748727009336 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 748727009337 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727009338 active site 748727009339 FMN binding site [chemical binding]; other site 748727009340 substrate binding site [chemical binding]; other site 748727009341 putative catalytic residue [active] 748727009342 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 748727009343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727009344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727009345 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 748727009346 active site 748727009347 metal binding site [ion binding]; metal-binding site 748727009348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727009350 putative substrate translocation pore; other site 748727009351 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 748727009352 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727009353 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748727009354 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748727009355 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 748727009356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 748727009357 TAP-like protein; Region: Abhydrolase_4; pfam08386 748727009358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727009360 putative substrate translocation pore; other site 748727009361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727009363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727009364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727009365 dimerization interface [polypeptide binding]; other site 748727009366 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 748727009367 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 748727009368 Putative amidase domain; Region: Amidase_6; pfam12671 748727009369 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727009370 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 748727009371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727009372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727009373 metal binding site [ion binding]; metal-binding site 748727009374 active site 748727009375 I-site; other site 748727009376 potential frameshift: common BLAST hit: gi|148245156|ref|YP_001219849.1| DNA methylase 748727009377 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 748727009378 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 748727009379 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727009380 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 748727009381 B3/4 domain; Region: B3_4; pfam03483 748727009382 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 748727009383 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 748727009384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748727009385 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748727009386 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748727009387 tetratricopeptide repeat protein; Provisional; Region: PRK11788 748727009388 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748727009389 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748727009390 active site 748727009391 metal binding site [ion binding]; metal-binding site 748727009392 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 748727009393 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 748727009394 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 748727009395 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 748727009396 Phage terminase large subunit; Region: Terminase_3; cl12054 748727009397 NUMOD4 motif; Region: NUMOD4; pfam07463 748727009398 HNH endonuclease; Region: HNH_3; pfam13392 748727009399 Phage terminase small subunit; Region: Phage_terminase; pfam10668 748727009400 Terminase small subunit; Region: Terminase_2; pfam03592 748727009401 KTSC domain; Region: KTSC; pfam13619 748727009402 YcfA-like protein; Region: YcfA; pfam07927 748727009403 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 748727009404 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 748727009405 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 748727009406 dockerin binding interface; other site 748727009407 Mu-like prophage protein Com; Region: Mu-like_Com; cl11540 748727009408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727009409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009410 non-specific DNA binding site [nucleotide binding]; other site 748727009411 salt bridge; other site 748727009412 sequence-specific DNA binding site [nucleotide binding]; other site 748727009413 Domain of unknown function (DUF955); Region: DUF955; cl01076 748727009414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009415 non-specific DNA binding site [nucleotide binding]; other site 748727009416 salt bridge; other site 748727009417 sequence-specific DNA binding site [nucleotide binding]; other site 748727009418 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 748727009419 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 748727009420 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 748727009421 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748727009422 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 748727009423 RecT family; Region: RecT; pfam03837 748727009424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727009425 AAA domain; Region: AAA_23; pfam13476 748727009426 Walker A/P-loop; other site 748727009427 ATP binding site [chemical binding]; other site 748727009428 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 748727009429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727009430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009431 non-specific DNA binding site [nucleotide binding]; other site 748727009432 salt bridge; other site 748727009433 sequence-specific DNA binding site [nucleotide binding]; other site 748727009434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727009435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009436 non-specific DNA binding site [nucleotide binding]; other site 748727009437 salt bridge; other site 748727009438 sequence-specific DNA binding site [nucleotide binding]; other site 748727009439 Domain of unknown function (DUF955); Region: DUF955; pfam06114 748727009440 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727009441 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 748727009442 Int/Topo IB signature motif; other site 748727009443 potential frameshift: common BLAST hit: gi|225870843|ref|YP_002746790.1| transposase 748727009444 Helix-turn-helix domain; Region: HTH_28; pfam13518 748727009445 Winged helix-turn helix; Region: HTH_29; pfam13551 748727009446 potential frameshift: common BLAST hit: gi|225870843|ref|YP_002746790.1| transposase 748727009447 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748727009448 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 748727009449 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 748727009450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748727009451 ABC-ATPase subunit interface; other site 748727009452 dimer interface [polypeptide binding]; other site 748727009453 putative PBP binding regions; other site 748727009454 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 748727009455 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 748727009456 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 748727009457 homodimer interface [polypeptide binding]; other site 748727009458 Walker A motif; other site 748727009459 ATP binding site [chemical binding]; other site 748727009460 hydroxycobalamin binding site [chemical binding]; other site 748727009461 Walker B motif; other site 748727009462 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 748727009463 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748727009464 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 748727009465 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 748727009466 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 748727009467 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 748727009468 active site 748727009469 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 748727009470 active site 748727009471 N-terminal domain interface [polypeptide binding]; other site 748727009472 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 748727009473 active site 748727009474 SAM binding site [chemical binding]; other site 748727009475 homodimer interface [polypeptide binding]; other site 748727009476 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 748727009477 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 748727009478 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 748727009479 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 748727009480 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 748727009481 active site 748727009482 SAM binding site [chemical binding]; other site 748727009483 homodimer interface [polypeptide binding]; other site 748727009484 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 748727009485 active site 748727009486 SAM binding site [chemical binding]; other site 748727009487 homodimer interface [polypeptide binding]; other site 748727009488 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 748727009489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727009490 S-adenosylmethionine binding site [chemical binding]; other site 748727009491 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 748727009492 active site 748727009493 putative homodimer interface [polypeptide binding]; other site 748727009494 SAM binding site [chemical binding]; other site 748727009495 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 748727009496 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 748727009497 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 748727009498 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 748727009499 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 748727009500 putative dimer interface [polypeptide binding]; other site 748727009501 active site pocket [active] 748727009502 putative cataytic base [active] 748727009503 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 748727009504 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727009505 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 748727009506 catalytic triad [active] 748727009507 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 748727009508 dimer interface [polypeptide binding]; other site 748727009509 active site 748727009510 Schiff base residues; other site 748727009511 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 748727009512 active site 748727009513 SAM binding site [chemical binding]; other site 748727009514 homodimer interface [polypeptide binding]; other site 748727009515 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 748727009516 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 748727009517 active site 748727009518 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 748727009519 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 748727009520 domain interfaces; other site 748727009521 active site 748727009522 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 748727009523 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 748727009524 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 748727009525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727009526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727009527 homodimer interface [polypeptide binding]; other site 748727009528 catalytic residue [active] 748727009529 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 748727009530 cobyric acid synthase; Provisional; Region: PRK00784 748727009531 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 748727009532 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 748727009533 catalytic triad [active] 748727009534 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748727009535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727009536 Walker A/P-loop; other site 748727009537 ATP binding site [chemical binding]; other site 748727009538 Q-loop/lid; other site 748727009539 ABC transporter signature motif; other site 748727009540 Walker B; other site 748727009541 D-loop; other site 748727009542 H-loop/switch region; other site 748727009543 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748727009544 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 748727009545 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 748727009546 dimer interface [polypeptide binding]; other site 748727009547 active site 748727009548 ADP-ribose binding site [chemical binding]; other site 748727009549 nudix motif; other site 748727009550 metal binding site [ion binding]; metal-binding site 748727009551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727009552 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727009553 DNA-binding site [nucleotide binding]; DNA binding site 748727009554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727009555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727009556 homodimer interface [polypeptide binding]; other site 748727009557 catalytic residue [active] 748727009558 Predicted membrane protein [Function unknown]; Region: COG1511 748727009559 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 748727009560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009561 Predicted membrane protein [Function unknown]; Region: COG1511 748727009562 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 748727009563 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 748727009564 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 748727009565 active site 748727009566 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 748727009567 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 748727009568 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 748727009569 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 748727009570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748727009571 alanine racemase; Reviewed; Region: alr; PRK00053 748727009572 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 748727009573 active site 748727009574 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748727009575 dimer interface [polypeptide binding]; other site 748727009576 substrate binding site [chemical binding]; other site 748727009577 catalytic residues [active] 748727009578 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748727009579 EamA-like transporter family; Region: EamA; pfam00892 748727009580 EamA-like transporter family; Region: EamA; pfam00892 748727009581 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 748727009582 putative homodimer interface [polypeptide binding]; other site 748727009583 putative homotetramer interface [polypeptide binding]; other site 748727009584 putative metal binding site [ion binding]; other site 748727009585 putative homodimer-homodimer interface [polypeptide binding]; other site 748727009586 putative allosteric switch controlling residues; other site 748727009587 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 748727009588 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727009589 Beta-Casp domain; Region: Beta-Casp; smart01027 748727009590 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748727009591 Putative amidase domain; Region: Amidase_6; pfam12671 748727009592 Protein of unknown function (DUF554); Region: DUF554; pfam04474 748727009593 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 748727009594 FMN binding site [chemical binding]; other site 748727009595 dimer interface [polypeptide binding]; other site 748727009596 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748727009597 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 748727009598 putative ligand binding site [chemical binding]; other site 748727009599 putative NAD binding site [chemical binding]; other site 748727009600 catalytic site [active] 748727009601 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 748727009602 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 748727009603 Protein of unknown function (DUF975); Region: DUF975; cl10504 748727009604 Protein of unknown function (DUF975); Region: DUF975; cl10504 748727009605 drug efflux system protein MdtG; Provisional; Region: PRK09874 748727009606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009607 putative substrate translocation pore; other site 748727009608 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 748727009609 active site 748727009610 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748727009611 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727009612 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748727009613 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 748727009614 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 748727009615 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748727009616 TfoX N-terminal domain; Region: TfoX_N; cl17592 748727009617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748727009618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727009619 Coenzyme A binding pocket [chemical binding]; other site 748727009620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727009621 S-adenosylmethionine binding site [chemical binding]; other site 748727009622 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748727009623 YvrJ protein family; Region: YvrJ; pfam12841 748727009624 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 748727009625 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 748727009626 EamA-like transporter family; Region: EamA; pfam00892 748727009627 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 748727009628 EamA-like transporter family; Region: EamA; pfam00892 748727009629 Abi-like protein; Region: Abi_2; cl01988 748727009630 Abi-like protein; Region: Abi_2; pfam07751 748727009631 AAA domain; Region: AAA_21; pfam13304 748727009632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727009633 Walker A/P-loop; other site 748727009634 ATP binding site [chemical binding]; other site 748727009635 RloB-like protein; Region: RloB; pfam13707 748727009636 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 748727009637 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727009638 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 748727009639 Int/Topo IB signature motif; other site 748727009640 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727009641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009642 non-specific DNA binding site [nucleotide binding]; other site 748727009643 salt bridge; other site 748727009644 sequence-specific DNA binding site [nucleotide binding]; other site 748727009645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727009646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009647 non-specific DNA binding site [nucleotide binding]; other site 748727009648 salt bridge; other site 748727009649 sequence-specific DNA binding site [nucleotide binding]; other site 748727009650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009651 non-specific DNA binding site [nucleotide binding]; other site 748727009652 salt bridge; other site 748727009653 sequence-specific DNA binding site [nucleotide binding]; other site 748727009654 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727009655 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748727009656 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009657 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009658 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727009659 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748727009660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727009661 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 748727009662 DNA binding residues [nucleotide binding] 748727009663 YvrJ protein family; Region: YvrJ; pfam12841 748727009664 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 748727009665 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 748727009666 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 748727009667 amidase catalytic site [active] 748727009668 Zn binding residues [ion binding]; other site 748727009669 substrate binding site [chemical binding]; other site 748727009670 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727009671 Ion channel; Region: Ion_trans_2; pfam07885 748727009672 DDE superfamily endonuclease; Region: DDE_5; cl17874 748727009673 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 748727009674 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748727009675 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 748727009676 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 748727009677 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 748727009678 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 748727009679 TIGR02687 family protein; Region: TIGR02687 748727009680 PglZ domain; Region: PglZ; pfam08665 748727009681 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 748727009682 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748727009683 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 748727009684 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 748727009685 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 748727009686 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 748727009687 Abi-like protein; Region: Abi_2; cl01988 748727009688 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 748727009689 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 748727009690 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727009691 MarR family; Region: MarR_2; pfam12802 748727009692 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 748727009693 ligand binding site [chemical binding]; other site 748727009694 NAD binding site [chemical binding]; other site 748727009695 dimerization interface [polypeptide binding]; other site 748727009696 catalytic site [active] 748727009697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009698 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727009699 putative substrate translocation pore; other site 748727009700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727009701 non-specific DNA binding site [nucleotide binding]; other site 748727009702 salt bridge; other site 748727009703 sequence-specific DNA binding site [nucleotide binding]; other site 748727009704 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 748727009705 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 748727009706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727009707 putative substrate translocation pore; other site 748727009708 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 748727009709 active sites [active] 748727009710 tetramer interface [polypeptide binding]; other site 748727009711 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 748727009712 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 748727009713 Na binding site [ion binding]; other site 748727009714 PAS domain; Region: PAS_9; pfam13426 748727009715 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 748727009716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727009717 Walker A motif; other site 748727009718 ATP binding site [chemical binding]; other site 748727009719 Walker B motif; other site 748727009720 arginine finger; other site 748727009721 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727009722 aspartate kinase; Reviewed; Region: PRK09034 748727009723 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 748727009724 nucleotide binding site [chemical binding]; other site 748727009725 substrate binding site [chemical binding]; other site 748727009726 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748727009727 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748727009728 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 748727009729 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 748727009730 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 748727009731 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 748727009732 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727009733 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727009734 Clp protease; Region: CLP_protease; pfam00574 748727009735 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 748727009736 oligomer interface [polypeptide binding]; other site 748727009737 active site residues [active] 748727009738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727009739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727009740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727009741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727009742 HAMP domain; Region: HAMP; pfam00672 748727009743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727009744 dimer interface [polypeptide binding]; other site 748727009745 phosphorylation site [posttranslational modification] 748727009746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727009747 ATP binding site [chemical binding]; other site 748727009748 Mg2+ binding site [ion binding]; other site 748727009749 G-X-G motif; other site 748727009750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727009751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727009752 active site 748727009753 phosphorylation site [posttranslational modification] 748727009754 intermolecular recognition site; other site 748727009755 dimerization interface [polypeptide binding]; other site 748727009756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727009757 DNA binding site [nucleotide binding] 748727009758 Man1-Src1p-C-terminal domain; Region: MSC; pfam09402 748727009759 Uncharacterized conserved protein [Function unknown]; Region: COG2454 748727009760 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 748727009761 ABC-2 type transporter; Region: ABC2_membrane; cl17235 748727009762 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748727009763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727009764 Walker A/P-loop; other site 748727009765 ATP binding site [chemical binding]; other site 748727009766 Q-loop/lid; other site 748727009767 ABC transporter signature motif; other site 748727009768 Walker B; other site 748727009769 D-loop; other site 748727009770 H-loop/switch region; other site 748727009771 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 748727009772 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 748727009773 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 748727009774 Ligand Binding Site [chemical binding]; other site 748727009775 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 748727009776 dimer interface [polypeptide binding]; other site 748727009777 substrate binding site [chemical binding]; other site 748727009778 ATP binding site [chemical binding]; other site 748727009779 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 748727009780 substrate binding site [chemical binding]; other site 748727009781 multimerization interface [polypeptide binding]; other site 748727009782 ATP binding site [chemical binding]; other site 748727009783 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 748727009784 thiamine phosphate binding site [chemical binding]; other site 748727009785 active site 748727009786 pyrophosphate binding site [ion binding]; other site 748727009787 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 748727009788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727009789 motif II; other site 748727009790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727009791 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 748727009792 nudix motif; other site 748727009793 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 748727009794 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 748727009795 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727009796 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727009797 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727009798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727009799 putative DNA binding site [nucleotide binding]; other site 748727009800 putative Zn2+ binding site [ion binding]; other site 748727009801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727009802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727009803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727009804 dimerization interface [polypeptide binding]; other site 748727009805 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748727009806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727009807 substrate binding pocket [chemical binding]; other site 748727009808 membrane-bound complex binding site; other site 748727009809 hinge residues; other site 748727009810 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748727009811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727009812 dimer interface [polypeptide binding]; other site 748727009813 conserved gate region; other site 748727009814 putative PBP binding loops; other site 748727009815 ABC-ATPase subunit interface; other site 748727009816 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727009817 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009818 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727009819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009820 dimer interface [polypeptide binding]; other site 748727009821 putative CheW interface [polypeptide binding]; other site 748727009822 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 748727009823 Part of AAA domain; Region: AAA_19; pfam13245 748727009824 Family description; Region: UvrD_C_2; pfam13538 748727009825 GAF domain; Region: GAF_3; pfam13492 748727009826 GAF domain; Region: GAF_2; pfam13185 748727009827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727009828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727009829 metal binding site [ion binding]; metal-binding site 748727009830 active site 748727009831 I-site; other site 748727009832 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 748727009833 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 748727009834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727009835 catalytic residue [active] 748727009836 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748727009837 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 748727009838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727009839 catalytic residue [active] 748727009840 cobalt transport protein CbiM; Provisional; Region: PRK07331 748727009841 cobalt transport protein CbiM; Provisional; Region: PRK11909 748727009842 PDGLE domain; Region: PDGLE; pfam13190 748727009843 lipoyl synthase; Provisional; Region: PRK05481 748727009844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727009845 FeS/SAM binding site; other site 748727009846 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 748727009847 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 748727009848 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 748727009849 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748727009850 DNA-binding site [nucleotide binding]; DNA binding site 748727009851 RNA-binding motif; other site 748727009852 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 748727009853 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 748727009854 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 748727009855 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 748727009856 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 748727009857 putative L-serine binding site [chemical binding]; other site 748727009858 aspartate aminotransferase; Provisional; Region: PRK09275 748727009859 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 748727009860 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748727009861 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748727009862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727009863 catalytic residue [active] 748727009864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727009865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727009866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727009867 dimerization interface [polypeptide binding]; other site 748727009868 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748727009869 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 748727009870 Predicted membrane protein [Function unknown]; Region: COG1511 748727009871 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 748727009872 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 748727009873 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 748727009874 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 748727009875 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 748727009876 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 748727009877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727009878 FeS/SAM binding site; other site 748727009879 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 748727009880 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 748727009881 dinuclear metal binding motif [ion binding]; other site 748727009882 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 748727009883 CotJB protein; Region: CotJB; pfam12652 748727009884 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 748727009885 dimanganese center [ion binding]; other site 748727009886 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748727009887 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 748727009888 putative ligand binding site [chemical binding]; other site 748727009889 putative NAD binding site [chemical binding]; other site 748727009890 catalytic site [active] 748727009891 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 748727009892 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 748727009893 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 748727009894 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748727009895 metal binding site [ion binding]; metal-binding site 748727009896 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 748727009897 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748727009898 phosphate binding site [ion binding]; other site 748727009899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727009900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727009901 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727009902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727009903 dimer interface [polypeptide binding]; other site 748727009904 putative CheW interface [polypeptide binding]; other site 748727009905 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727009906 VanW like protein; Region: VanW; pfam04294 748727009907 putative hydrolase; Validated; Region: PRK09248 748727009908 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 748727009909 active site 748727009910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 748727009911 active site 748727009912 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 748727009913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727009914 UDP-galactopyranose mutase; Region: GLF; pfam03275 748727009915 Coat F domain; Region: Coat_F; pfam07875 748727009916 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 748727009917 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 748727009918 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 748727009919 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 748727009920 [2Fe-2S] cluster binding site [ion binding]; other site 748727009921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 748727009922 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 748727009923 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 748727009924 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748727009925 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748727009926 catalytic residue [active] 748727009927 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 748727009928 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 748727009929 CoA-binding site [chemical binding]; other site 748727009930 ATP-binding [chemical binding]; other site 748727009931 DNA polymerase I; Provisional; Region: PRK05755 748727009932 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 748727009933 active site 748727009934 metal binding site 1 [ion binding]; metal-binding site 748727009935 putative 5' ssDNA interaction site; other site 748727009936 metal binding site 3; metal-binding site 748727009937 metal binding site 2 [ion binding]; metal-binding site 748727009938 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 748727009939 putative DNA binding site [nucleotide binding]; other site 748727009940 putative metal binding site [ion binding]; other site 748727009941 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 748727009942 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 748727009943 active site 748727009944 DNA binding site [nucleotide binding] 748727009945 catalytic site [active] 748727009946 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 748727009947 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 748727009948 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 748727009949 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 748727009950 dimer interface [polypeptide binding]; other site 748727009951 anticodon binding site; other site 748727009952 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 748727009953 homodimer interface [polypeptide binding]; other site 748727009954 motif 1; other site 748727009955 active site 748727009956 motif 2; other site 748727009957 GAD domain; Region: GAD; pfam02938 748727009958 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 748727009959 motif 3; other site 748727009960 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 748727009961 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 748727009962 dimer interface [polypeptide binding]; other site 748727009963 motif 1; other site 748727009964 active site 748727009965 motif 2; other site 748727009966 motif 3; other site 748727009967 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 748727009968 anticodon binding site; other site 748727009969 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 748727009970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727009971 FeS/SAM binding site; other site 748727009972 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748727009973 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 748727009974 putative active site [active] 748727009975 dimerization interface [polypeptide binding]; other site 748727009976 putative tRNAtyr binding site [nucleotide binding]; other site 748727009977 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 748727009978 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727009979 Zn2+ binding site [ion binding]; other site 748727009980 Mg2+ binding site [ion binding]; other site 748727009981 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748727009982 synthetase active site [active] 748727009983 NTP binding site [chemical binding]; other site 748727009984 metal binding site [ion binding]; metal-binding site 748727009985 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 748727009986 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 748727009987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727009988 active site 748727009989 DHH family; Region: DHH; pfam01368 748727009990 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 748727009991 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 748727009992 Protein export membrane protein; Region: SecD_SecF; cl14618 748727009993 protein-export membrane protein SecD; Region: secD; TIGR01129 748727009994 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 748727009995 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 748727009996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727009997 FeS/SAM binding site; other site 748727009998 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 748727009999 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 748727010000 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 748727010001 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 748727010002 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 748727010003 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 748727010004 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 748727010005 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 748727010006 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 748727010007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727010008 Walker A motif; other site 748727010009 ATP binding site [chemical binding]; other site 748727010010 Walker B motif; other site 748727010011 arginine finger; other site 748727010012 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 748727010013 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 748727010014 RuvA N terminal domain; Region: RuvA_N; pfam01330 748727010015 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 748727010016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 748727010017 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 748727010018 YceG-like family; Region: YceG; pfam02618 748727010019 dimerization interface [polypeptide binding]; other site 748727010020 hypothetical protein; Validated; Region: PRK00110 748727010021 Uncharacterized conserved protein [Function unknown]; Region: COG1739 748727010022 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 748727010023 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 748727010024 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727010025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727010026 DNA-binding site [nucleotide binding]; DNA binding site 748727010027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727010028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727010029 homodimer interface [polypeptide binding]; other site 748727010030 catalytic residue [active] 748727010031 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 748727010032 active site 748727010033 NTP binding site [chemical binding]; other site 748727010034 metal binding triad [ion binding]; metal-binding site 748727010035 antibiotic binding site [chemical binding]; other site 748727010036 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 748727010037 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 748727010038 HflX GTPase family; Region: HflX; cd01878 748727010039 G1 box; other site 748727010040 GTP/Mg2+ binding site [chemical binding]; other site 748727010041 Switch I region; other site 748727010042 G2 box; other site 748727010043 G3 box; other site 748727010044 Switch II region; other site 748727010045 G4 box; other site 748727010046 G5 box; other site 748727010047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727010048 active site 748727010049 sporulation protein YunB; Region: spo_yunB; TIGR02832 748727010050 Transglycosylase; Region: Transgly; pfam00912 748727010051 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 748727010052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748727010053 sporulation sigma factor SigF; Validated; Region: PRK05572 748727010054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727010055 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748727010056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727010057 DNA binding residues [nucleotide binding] 748727010058 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 748727010059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727010060 ATP binding site [chemical binding]; other site 748727010061 Mg2+ binding site [ion binding]; other site 748727010062 G-X-G motif; other site 748727010063 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 748727010064 anti sigma factor interaction site; other site 748727010065 regulatory phosphorylation site [posttranslational modification]; other site 748727010066 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748727010067 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 748727010068 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 748727010069 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 748727010070 NodB motif; other site 748727010071 active site 748727010072 catalytic site [active] 748727010073 Cd binding site [ion binding]; other site 748727010074 Rrf2 family protein; Region: rrf2_super; TIGR00738 748727010075 Transcriptional regulator; Region: Rrf2; pfam02082 748727010076 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 748727010077 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 748727010078 Bacterial sugar transferase; Region: Bac_transf; pfam02397 748727010079 Acyltransferase family; Region: Acyl_transf_3; pfam01757 748727010080 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 748727010081 integral membrane protein MviN; Region: mviN; TIGR01695 748727010082 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 748727010083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727010084 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 748727010085 O-Antigen ligase; Region: Wzy_C; cl04850 748727010086 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 748727010087 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 748727010088 active site 748727010089 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 748727010090 homodimer interface [polypeptide binding]; other site 748727010091 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748727010092 putative trimer interface [polypeptide binding]; other site 748727010093 putative CoA binding site [chemical binding]; other site 748727010094 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 748727010095 putative trimer interface [polypeptide binding]; other site 748727010096 putative active site [active] 748727010097 putative substrate binding site [chemical binding]; other site 748727010098 putative CoA binding site [chemical binding]; other site 748727010099 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748727010100 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748727010101 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 748727010102 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 748727010103 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 748727010104 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 748727010105 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748727010106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748727010107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748727010108 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 748727010109 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 748727010110 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 748727010111 Acyltransferase family; Region: Acyl_transf_3; pfam01757 748727010112 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 748727010113 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748727010114 Ligand binding site; other site 748727010115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727010116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748727010117 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 748727010118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748727010119 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 748727010120 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748727010121 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 748727010122 NAD(P) binding site [chemical binding]; other site 748727010123 homodimer interface [polypeptide binding]; other site 748727010124 substrate binding site [chemical binding]; other site 748727010125 active site 748727010126 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 748727010127 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 748727010128 active site 748727010129 tetramer interface; other site 748727010130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727010131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727010132 binding surface 748727010133 TPR motif; other site 748727010134 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748727010135 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 748727010136 active site 748727010137 substrate binding site [chemical binding]; other site 748727010138 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 748727010139 metal binding site [ion binding]; metal-binding site 748727010140 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 748727010141 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 748727010142 homodimer interface [polypeptide binding]; other site 748727010143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727010144 catalytic residue [active] 748727010145 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 748727010146 RNA polymerase factor sigma-70; Validated; Region: PRK06811 748727010147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727010148 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748727010149 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 748727010150 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727010151 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727010152 topology modulation protein; Reviewed; Region: PRK08118 748727010153 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK13951 748727010154 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 748727010155 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 748727010156 active site 748727010157 HIGH motif; other site 748727010158 dimer interface [polypeptide binding]; other site 748727010159 KMSKS motif; other site 748727010160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727010161 RNA binding surface [nucleotide binding]; other site 748727010162 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 748727010163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748727010164 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727010165 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727010166 manganese transport protein MntH; Reviewed; Region: PRK00701 748727010167 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 748727010168 manganese transport transcriptional regulator; Provisional; Region: PRK03902 748727010169 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 748727010170 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 748727010171 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 748727010172 active site 748727010173 substrate binding site [chemical binding]; other site 748727010174 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 748727010175 FMN binding site [chemical binding]; other site 748727010176 putative catalytic residues [active] 748727010177 Uncharacterized conserved protein [Function unknown]; Region: COG1683 748727010178 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 748727010179 MutS domain III; Region: MutS_III; pfam05192 748727010180 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 748727010181 Walker A/P-loop; other site 748727010182 ATP binding site [chemical binding]; other site 748727010183 Q-loop/lid; other site 748727010184 ABC transporter signature motif; other site 748727010185 Walker B; other site 748727010186 D-loop; other site 748727010187 H-loop/switch region; other site 748727010188 Smr domain; Region: Smr; pfam01713 748727010189 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 748727010190 Peptidase family U32; Region: Peptidase_U32; pfam01136 748727010191 Collagenase; Region: DUF3656; pfam12392 748727010192 Peptidase family U32; Region: Peptidase_U32; pfam01136 748727010193 Cell division protein ZapA; Region: ZapA; pfam05164 748727010194 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 748727010195 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 748727010196 putative tRNA-binding site [nucleotide binding]; other site 748727010197 B3/4 domain; Region: B3_4; pfam03483 748727010198 tRNA synthetase B5 domain; Region: B5; smart00874 748727010199 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 748727010200 dimer interface [polypeptide binding]; other site 748727010201 motif 1; other site 748727010202 motif 3; other site 748727010203 motif 2; other site 748727010204 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 748727010205 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 748727010206 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 748727010207 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 748727010208 dimer interface [polypeptide binding]; other site 748727010209 motif 1; other site 748727010210 active site 748727010211 motif 2; other site 748727010212 motif 3; other site 748727010213 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 748727010214 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 748727010215 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748727010216 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 748727010217 23S rRNA binding site [nucleotide binding]; other site 748727010218 L21 binding site [polypeptide binding]; other site 748727010219 L13 binding site [polypeptide binding]; other site 748727010220 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 748727010221 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 748727010222 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 748727010223 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 748727010224 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 748727010225 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 748727010226 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748727010227 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 748727010228 active site 748727010229 dimer interface [polypeptide binding]; other site 748727010230 motif 1; other site 748727010231 motif 2; other site 748727010232 motif 3; other site 748727010233 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 748727010234 anticodon binding site; other site 748727010235 YtxC-like family; Region: YtxC; pfam08812 748727010236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 748727010237 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748727010238 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748727010239 aminotransferase A; Validated; Region: PRK07683 748727010240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727010241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727010242 homodimer interface [polypeptide binding]; other site 748727010243 catalytic residue [active] 748727010244 dihydrodipicolinate reductase; Provisional; Region: PRK00048 748727010245 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 748727010246 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 748727010247 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 748727010248 dihydrodipicolinate synthase; Region: dapA; TIGR00674 748727010249 dimer interface [polypeptide binding]; other site 748727010250 active site 748727010251 catalytic residue [active] 748727010252 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 748727010253 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 748727010254 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748727010255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727010256 S-adenosylmethionine binding site [chemical binding]; other site 748727010257 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 748727010258 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 748727010259 dimerization interface [polypeptide binding]; other site 748727010260 domain crossover interface; other site 748727010261 redox-dependent activation switch; other site 748727010262 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 748727010263 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 748727010264 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 748727010265 trimer interface [polypeptide binding]; other site 748727010266 active site 748727010267 substrate binding site [chemical binding]; other site 748727010268 CoA binding site [chemical binding]; other site 748727010269 single-stranded DNA-binding protein; Provisional; Region: PRK05813 748727010270 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748727010271 dimer interface [polypeptide binding]; other site 748727010272 ssDNA binding site [nucleotide binding]; other site 748727010273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748727010274 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 748727010275 NodB motif; other site 748727010276 active site 748727010277 catalytic site [active] 748727010278 metal binding site [ion binding]; metal-binding site 748727010279 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 748727010280 Uncharacterized conserved protein [Function unknown]; Region: COG3391 748727010281 TSCPD domain; Region: TSCPD; cl14834 748727010282 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 748727010283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748727010284 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 748727010285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748727010286 active site 748727010287 HIGH motif; other site 748727010288 nucleotide binding site [chemical binding]; other site 748727010289 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748727010290 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 748727010291 active site 748727010292 KMSKS motif; other site 748727010293 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 748727010294 tRNA binding surface [nucleotide binding]; other site 748727010295 anticodon binding site; other site 748727010296 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 748727010297 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 748727010298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 748727010299 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727010300 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 748727010301 stationary phase survival protein SurE; Provisional; Region: PRK13933 748727010302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727010303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727010304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727010305 dimerization interface [polypeptide binding]; other site 748727010306 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 748727010307 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 748727010308 ligand binding site [chemical binding]; other site 748727010309 NAD binding site [chemical binding]; other site 748727010310 catalytic site [active] 748727010311 hypothetical protein; Validated; Region: PRK06201 748727010312 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 748727010313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010314 D-galactonate transporter; Region: 2A0114; TIGR00893 748727010315 putative substrate translocation pore; other site 748727010316 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 748727010317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727010318 active site 748727010319 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727010320 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727010321 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 748727010322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727010323 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 748727010324 TM-ABC transporter signature motif; other site 748727010325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727010326 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 748727010327 TM-ABC transporter signature motif; other site 748727010328 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 748727010329 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748727010330 Walker A/P-loop; other site 748727010331 ATP binding site [chemical binding]; other site 748727010332 Q-loop/lid; other site 748727010333 ABC transporter signature motif; other site 748727010334 Walker B; other site 748727010335 D-loop; other site 748727010336 H-loop/switch region; other site 748727010337 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748727010338 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 748727010339 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 748727010340 putative ligand binding site [chemical binding]; other site 748727010341 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 748727010342 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748727010343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727010344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727010345 WHG domain; Region: WHG; pfam13305 748727010346 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 748727010347 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 748727010348 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 748727010349 NAD(P) binding site [chemical binding]; other site 748727010350 homotetramer interface [polypeptide binding]; other site 748727010351 homodimer interface [polypeptide binding]; other site 748727010352 active site 748727010353 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 748727010354 Mor transcription activator family; Region: Mor; cl02360 748727010355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 748727010356 hydrophobic ligand binding site; other site 748727010357 AAA domain; Region: AAA_18; pfam13238 748727010358 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 748727010359 putative FMN binding site [chemical binding]; other site 748727010360 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748727010361 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 748727010362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727010363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727010364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727010366 putative substrate translocation pore; other site 748727010367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010368 putative substrate translocation pore; other site 748727010369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748727010370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727010371 Coenzyme A binding pocket [chemical binding]; other site 748727010372 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 748727010373 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 748727010374 substrate binding site [chemical binding]; other site 748727010375 multimerization interface [polypeptide binding]; other site 748727010376 ATP binding site [chemical binding]; other site 748727010377 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 748727010378 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727010379 DNA binding residues [nucleotide binding] 748727010380 dimer interface [polypeptide binding]; other site 748727010381 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 748727010382 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 748727010383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727010384 Coenzyme A binding pocket [chemical binding]; other site 748727010385 Putative esterase; Region: Esterase; pfam00756 748727010386 TfoX C-terminal domain; Region: TfoX_C; pfam04994 748727010387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727010388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748727010389 Coenzyme A binding pocket [chemical binding]; other site 748727010390 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 748727010391 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727010392 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 748727010393 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 748727010394 active site 748727010395 putative substrate binding region [chemical binding]; other site 748727010396 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 748727010397 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 748727010398 conserved cys residue [active] 748727010399 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010400 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 748727010401 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010402 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010403 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727010404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727010405 active site 748727010406 phosphorylation site [posttranslational modification] 748727010407 intermolecular recognition site; other site 748727010408 LytTr DNA-binding domain; Region: LytTR; pfam04397 748727010409 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 748727010410 ATP binding site [chemical binding]; other site 748727010411 Mg2+ binding site [ion binding]; other site 748727010412 G-X-G motif; other site 748727010413 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727010414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727010415 Walker A/P-loop; other site 748727010416 ATP binding site [chemical binding]; other site 748727010417 Q-loop/lid; other site 748727010418 ABC transporter signature motif; other site 748727010419 Walker B; other site 748727010420 D-loop; other site 748727010421 H-loop/switch region; other site 748727010422 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727010423 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 748727010424 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 748727010425 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748727010426 Beta-lactamase; Region: Beta-lactamase; pfam00144 748727010427 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 748727010428 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 748727010429 FMN binding site [chemical binding]; other site 748727010430 dimer interface [polypeptide binding]; other site 748727010431 Short C-terminal domain; Region: SHOCT; pfam09851 748727010432 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 748727010433 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 748727010434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727010435 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748727010436 Walker A/P-loop; other site 748727010437 ATP binding site [chemical binding]; other site 748727010438 Q-loop/lid; other site 748727010439 ABC transporter signature motif; other site 748727010440 Walker B; other site 748727010441 D-loop; other site 748727010442 H-loop/switch region; other site 748727010443 Predicted transcriptional regulators [Transcription]; Region: COG1725 748727010444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727010445 DNA-binding site [nucleotide binding]; DNA binding site 748727010446 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 748727010447 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 748727010448 catalytic residues [active] 748727010449 catalytic nucleophile [active] 748727010450 Recombinase; Region: Recombinase; pfam07508 748727010451 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 748727010452 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 748727010453 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 748727010454 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 748727010455 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 748727010456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 748727010457 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 748727010458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 748727010459 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 748727010460 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 748727010461 Walker A/P-loop; other site 748727010462 ATP binding site [chemical binding]; other site 748727010463 Q-loop/lid; other site 748727010464 ABC transporter signature motif; other site 748727010465 Walker B; other site 748727010466 D-loop; other site 748727010467 H-loop/switch region; other site 748727010468 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 748727010469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 748727010470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727010471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727010472 binding surface 748727010473 TPR motif; other site 748727010474 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 748727010475 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 748727010476 recombination regulator RecX; Provisional; Region: recX; PRK14134 748727010477 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 748727010478 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 748727010479 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748727010480 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 748727010481 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 748727010482 ATP binding site [chemical binding]; other site 748727010483 Mg++ binding site [ion binding]; other site 748727010484 motif III; other site 748727010485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727010486 nucleotide binding region [chemical binding]; other site 748727010487 ATP-binding site [chemical binding]; other site 748727010488 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 748727010489 RNA binding site [nucleotide binding]; other site 748727010490 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 748727010491 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 748727010492 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748727010493 transcription elongation factor GreA; Region: greA; TIGR01462 748727010494 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748727010495 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748727010496 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748727010497 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 748727010498 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 748727010499 catalytic residue [active] 748727010500 putative FPP diphosphate binding site; other site 748727010501 putative FPP binding hydrophobic cleft; other site 748727010502 dimer interface [polypeptide binding]; other site 748727010503 putative IPP diphosphate binding site; other site 748727010504 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 748727010505 Cation efflux family; Region: Cation_efflux; pfam01545 748727010506 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 748727010507 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 748727010508 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 748727010509 ApbE family; Region: ApbE; pfam02424 748727010510 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 748727010511 homotrimer interface [polypeptide binding]; other site 748727010512 Walker A motif; other site 748727010513 GTP binding site [chemical binding]; other site 748727010514 Walker B motif; other site 748727010515 cobalamin synthase; Reviewed; Region: cobS; PRK00235 748727010516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748727010517 catalytic core [active] 748727010518 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727010519 metal binding site 2 [ion binding]; metal-binding site 748727010520 putative DNA binding helix; other site 748727010521 metal binding site 1 [ion binding]; metal-binding site 748727010522 dimer interface [polypeptide binding]; other site 748727010523 structural Zn2+ binding site [ion binding]; other site 748727010524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748727010525 Family description; Region: VCBS; pfam13517 748727010526 Predicted transcriptional regulator [Transcription]; Region: COG2378 748727010527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727010528 putative DNA binding site [nucleotide binding]; other site 748727010529 putative Zn2+ binding site [ion binding]; other site 748727010530 WYL domain; Region: WYL; pfam13280 748727010531 CAAX protease self-immunity; Region: Abi; pfam02517 748727010532 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 748727010533 G1 box; other site 748727010534 GTP/Mg2+ binding site [chemical binding]; other site 748727010535 Switch I region; other site 748727010536 G2 box; other site 748727010537 G3 box; other site 748727010538 Switch II region; other site 748727010539 G4 box; other site 748727010540 G5 box; other site 748727010541 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 748727010542 Found in ATP-dependent protease La (LON); Region: LON; smart00464 748727010543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727010544 Walker A motif; other site 748727010545 ATP binding site [chemical binding]; other site 748727010546 Walker B motif; other site 748727010547 arginine finger; other site 748727010548 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748727010549 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 748727010550 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 748727010551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727010552 Walker A motif; other site 748727010553 ATP binding site [chemical binding]; other site 748727010554 Walker B motif; other site 748727010555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748727010556 Clp protease; Region: CLP_protease; pfam00574 748727010557 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 748727010558 oligomer interface [polypeptide binding]; other site 748727010559 active site residues [active] 748727010560 trigger factor; Provisional; Region: tig; PRK01490 748727010561 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 748727010562 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 748727010563 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 748727010564 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 748727010565 DNA interaction; other site 748727010566 Metal-binding active site; metal-binding site 748727010567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727010568 active site 748727010569 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 748727010570 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 748727010571 heterodimer interface [polypeptide binding]; other site 748727010572 active site 748727010573 FMN binding site [chemical binding]; other site 748727010574 homodimer interface [polypeptide binding]; other site 748727010575 substrate binding site [chemical binding]; other site 748727010576 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 748727010577 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 748727010578 FAD binding pocket [chemical binding]; other site 748727010579 FAD binding motif [chemical binding]; other site 748727010580 phosphate binding motif [ion binding]; other site 748727010581 beta-alpha-beta structure motif; other site 748727010582 NAD binding pocket [chemical binding]; other site 748727010583 Iron coordination center [ion binding]; other site 748727010584 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 748727010585 active site 748727010586 dimer interface [polypeptide binding]; other site 748727010587 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 748727010588 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 748727010589 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 748727010590 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 748727010591 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727010592 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727010593 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 748727010594 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 748727010595 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 748727010596 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 748727010597 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 748727010598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010599 putative substrate translocation pore; other site 748727010600 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 748727010601 active site 748727010602 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748727010603 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748727010604 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748727010605 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748727010606 Probable zinc-binding domain; Region: zf-trcl; pfam13451 748727010607 potential frameshift: common BLAST hit: gi|153954852|ref|YP_001395617.1| signal transduction protein 748727010608 potential frameshift: common BLAST hit: gi|150018132|ref|YP_001310386.1| diguanylate cyclase/phosphodiesterase 748727010609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748727010610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 748727010611 manganese transport protein MntH; Reviewed; Region: PRK00701 748727010612 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 748727010613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727010614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727010615 WHG domain; Region: WHG; pfam13305 748727010616 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 748727010617 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 748727010618 homodimer interface [polypeptide binding]; other site 748727010619 active site 748727010620 FMN binding site [chemical binding]; other site 748727010621 substrate binding site [chemical binding]; other site 748727010622 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 748727010623 phenylhydantoinase; Validated; Region: PRK08323 748727010624 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 748727010625 tetramer interface [polypeptide binding]; other site 748727010626 active site 748727010627 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 748727010628 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 748727010629 Na binding site [ion binding]; other site 748727010630 putative substrate binding site [chemical binding]; other site 748727010631 allantoate amidohydrolase; Reviewed; Region: PRK09290 748727010632 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 748727010633 active site 748727010634 metal binding site [ion binding]; metal-binding site 748727010635 dimer interface [polypeptide binding]; other site 748727010636 hypothetical protein; Provisional; Region: PRK06062 748727010637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748727010638 inhibitor-cofactor binding pocket; inhibition site 748727010639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727010640 catalytic residue [active] 748727010641 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727010642 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 748727010643 active site 748727010644 NAD binding site [chemical binding]; other site 748727010645 metal binding site [ion binding]; metal-binding site 748727010646 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 748727010647 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 748727010648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727010649 metal binding site [ion binding]; metal-binding site 748727010650 I-site; other site 748727010651 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 748727010652 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727010653 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727010654 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727010655 Spore germination protein; Region: Spore_permease; cl17796 748727010656 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 748727010657 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 748727010658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727010659 catalytic residue [active] 748727010660 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 748727010661 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 748727010662 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 748727010663 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 748727010664 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 748727010665 glutamine binding [chemical binding]; other site 748727010666 catalytic triad [active] 748727010667 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 748727010668 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 748727010669 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727010670 DNA binding residues [nucleotide binding] 748727010671 putative dimer interface [polypeptide binding]; other site 748727010672 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727010673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727010674 metal binding site [ion binding]; metal-binding site 748727010675 active site 748727010676 I-site; other site 748727010677 YvrJ protein family; Region: YvrJ; pfam12841 748727010678 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 748727010679 Hemerythrin; Region: Hemerythrin; cd12107 748727010680 Fe binding site [ion binding]; other site 748727010681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727010682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010683 putative substrate translocation pore; other site 748727010684 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 748727010685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727010686 putative active site [active] 748727010687 putative metal binding site [ion binding]; other site 748727010688 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 748727010689 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 748727010690 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 748727010691 active site 748727010692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727010693 binding surface 748727010694 TPR motif; other site 748727010695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727010696 binding surface 748727010697 TPR repeat; Region: TPR_11; pfam13414 748727010698 TPR motif; other site 748727010699 TPR repeat; Region: TPR_11; pfam13414 748727010700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727010701 binding surface 748727010702 TPR repeat; Region: TPR_11; pfam13414 748727010703 TPR motif; other site 748727010704 Chromate transporter; Region: Chromate_transp; pfam02417 748727010705 Chromate transporter; Region: Chromate_transp; pfam02417 748727010706 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 748727010707 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727010708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727010709 dimerization interface [polypeptide binding]; other site 748727010710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727010711 dimer interface [polypeptide binding]; other site 748727010712 putative CheW interface [polypeptide binding]; other site 748727010713 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 748727010714 putative FMN binding site [chemical binding]; other site 748727010715 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 748727010716 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 748727010717 active site 748727010718 catalytic site [active] 748727010719 substrate binding site [chemical binding]; other site 748727010720 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 748727010721 Dimer interface [polypeptide binding]; other site 748727010722 BRCT sequence motif; other site 748727010723 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 748727010724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727010725 FeS/SAM binding site; other site 748727010726 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 748727010727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727010728 S-adenosylmethionine binding site [chemical binding]; other site 748727010729 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 748727010730 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 748727010731 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748727010732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727010733 putative active site [active] 748727010734 heme pocket [chemical binding]; other site 748727010735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727010736 Walker A motif; other site 748727010737 ATP binding site [chemical binding]; other site 748727010738 Walker B motif; other site 748727010739 arginine finger; other site 748727010740 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 748727010741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727010742 AAA domain; Region: AAA_21; pfam13304 748727010743 Walker A/P-loop; other site 748727010744 ATP binding site [chemical binding]; other site 748727010745 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010746 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010747 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010748 Domain of unknown function (DUF955); Region: DUF955; pfam06114 748727010749 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748727010750 active site 748727010751 catalytic site [active] 748727010752 substrate binding site [chemical binding]; other site 748727010753 Terminase small subunit; Region: Terminase_2; cl01513 748727010754 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 748727010755 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010756 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010757 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 748727010758 NlpC/P60 family; Region: NLPC_P60; cl17555 748727010759 Homeodomain-like domain; Region: HTH_23; pfam13384 748727010760 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748727010761 DNA binding residues [nucleotide binding] 748727010762 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 748727010763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727010764 ATP binding site [chemical binding]; other site 748727010765 putative Mg++ binding site [ion binding]; other site 748727010766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727010767 nucleotide binding region [chemical binding]; other site 748727010768 ATP-binding site [chemical binding]; other site 748727010769 HNH endonuclease; Region: HNH_3; pfam13392 748727010770 VRR-NUC domain; Region: VRR_NUC; pfam08774 748727010771 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 748727010772 Virulence-associated protein E; Region: VirE; pfam05272 748727010773 SIR2-like domain; Region: SIR2_2; pfam13289 748727010774 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 748727010775 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 748727010776 DNA binding site [nucleotide binding] 748727010777 active site 748727010778 catalytic site [active] 748727010779 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 748727010780 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 748727010781 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 748727010782 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 748727010783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727010784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748727010785 DNA binding residues [nucleotide binding] 748727010786 Helix-turn-helix domain; Region: HTH_17; pfam12728 748727010787 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 748727010788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727010789 non-specific DNA binding site [nucleotide binding]; other site 748727010790 salt bridge; other site 748727010791 sequence-specific DNA binding site [nucleotide binding]; other site 748727010792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727010793 sequence-specific DNA binding site [nucleotide binding]; other site 748727010794 salt bridge; other site 748727010795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727010796 non-specific DNA binding site [nucleotide binding]; other site 748727010797 salt bridge; other site 748727010798 sequence-specific DNA binding site [nucleotide binding]; other site 748727010799 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 748727010800 Catalytic site [active] 748727010801 integrase/recombinase; Provisional; Region: PRK15417 748727010802 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 748727010803 Int/Topo IB signature motif; other site 748727010804 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 748727010805 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748727010806 active site 748727010807 metal binding site [ion binding]; metal-binding site 748727010808 homotetramer interface [polypeptide binding]; other site 748727010809 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 748727010810 active site 748727010811 dimerization interface [polypeptide binding]; other site 748727010812 ribonuclease PH; Reviewed; Region: rph; PRK00173 748727010813 Ribonuclease PH; Region: RNase_PH_bact; cd11362 748727010814 hexamer interface [polypeptide binding]; other site 748727010815 active site 748727010816 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 748727010817 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 748727010818 dimerization interface [polypeptide binding]; other site 748727010819 putative ATP binding site [chemical binding]; other site 748727010820 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 748727010821 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748727010822 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748727010823 peptide binding site [polypeptide binding]; other site 748727010824 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 748727010825 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 748727010826 GatB domain; Region: GatB_Yqey; smart00845 748727010827 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 748727010828 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 748727010829 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 748727010830 Peptidase C26; Region: Peptidase_C26; pfam07722 748727010831 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 748727010832 catalytic triad [active] 748727010833 PAS domain; Region: PAS; smart00091 748727010834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727010835 Walker A motif; other site 748727010836 ATP binding site [chemical binding]; other site 748727010837 Walker B motif; other site 748727010838 arginine finger; other site 748727010839 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 748727010840 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 748727010841 nucleotide binding pocket [chemical binding]; other site 748727010842 K-X-D-G motif; other site 748727010843 catalytic site [active] 748727010844 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 748727010845 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 748727010846 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 748727010847 Dimer interface [polypeptide binding]; other site 748727010848 BRCT sequence motif; other site 748727010849 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 748727010850 Part of AAA domain; Region: AAA_19; pfam13245 748727010851 Family description; Region: UvrD_C_2; pfam13538 748727010852 Trp repressor protein; Region: Trp_repressor; cl17266 748727010853 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748727010854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727010855 RNA binding surface [nucleotide binding]; other site 748727010856 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 748727010857 active site 748727010858 uracil binding [chemical binding]; other site 748727010859 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 748727010860 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748727010861 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748727010862 catalytic residue [active] 748727010863 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 748727010864 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 748727010865 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 748727010866 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 748727010867 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 748727010868 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727010869 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 748727010870 B3/4 domain; Region: B3_4; pfam03483 748727010871 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 748727010872 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 748727010873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748727010874 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748727010875 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748727010876 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 748727010877 hypothetical protein; Validated; Region: PRK00124 748727010878 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 748727010879 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727010880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727010881 dimerization interface [polypeptide binding]; other site 748727010882 putative DNA binding site [nucleotide binding]; other site 748727010883 putative Zn2+ binding site [ion binding]; other site 748727010884 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 748727010885 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 748727010886 active site 748727010887 dimer interface [polypeptide binding]; other site 748727010888 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 748727010889 dimer interface [polypeptide binding]; other site 748727010890 active site 748727010891 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727010892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727010893 dimer interface [polypeptide binding]; other site 748727010894 putative CheW interface [polypeptide binding]; other site 748727010895 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748727010896 G4 box; other site 748727010897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727010898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727010899 putative substrate translocation pore; other site 748727010900 GMP synthase; Reviewed; Region: guaA; PRK00074 748727010901 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 748727010902 AMP/PPi binding site [chemical binding]; other site 748727010903 candidate oxyanion hole; other site 748727010904 catalytic triad [active] 748727010905 potential glutamine specificity residues [chemical binding]; other site 748727010906 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 748727010907 ATP Binding subdomain [chemical binding]; other site 748727010908 Ligand Binding sites [chemical binding]; other site 748727010909 Dimerization subdomain; other site 748727010910 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 748727010911 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748727010912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 748727010913 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 748727010914 active site 748727010915 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 748727010916 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 748727010917 ring oligomerisation interface [polypeptide binding]; other site 748727010918 ATP/Mg binding site [chemical binding]; other site 748727010919 stacking interactions; other site 748727010920 hinge regions; other site 748727010921 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 748727010922 oligomerisation interface [polypeptide binding]; other site 748727010923 mobile loop; other site 748727010924 roof hairpin; other site 748727010925 Uncharacterized conserved protein [Function unknown]; Region: COG0398 748727010926 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748727010927 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 748727010928 4Fe-4S binding domain; Region: Fer4; pfam00037 748727010929 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748727010930 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 748727010931 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 748727010932 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 748727010933 minor groove reading motif; other site 748727010934 helix-hairpin-helix signature motif; other site 748727010935 substrate binding pocket [chemical binding]; other site 748727010936 active site 748727010937 putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778 748727010938 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 748727010939 FAD binding pocket [chemical binding]; other site 748727010940 FAD binding motif [chemical binding]; other site 748727010941 phosphate binding motif [ion binding]; other site 748727010942 beta-alpha-beta structure motif; other site 748727010943 NAD binding pocket [chemical binding]; other site 748727010944 Iron coordination center [ion binding]; other site 748727010945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748727010946 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 748727010947 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 748727010948 CoA binding domain; Region: CoA_binding; pfam02629 748727010949 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748727010950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727010951 Walker A/P-loop; other site 748727010952 ATP binding site [chemical binding]; other site 748727010953 Q-loop/lid; other site 748727010954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727010955 ABC transporter signature motif; other site 748727010956 Walker B; other site 748727010957 D-loop; other site 748727010958 H-loop/switch region; other site 748727010959 ABC transporter; Region: ABC_tran_2; pfam12848 748727010960 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727010961 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 748727010962 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 748727010963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748727010964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727010965 Walker A/P-loop; other site 748727010966 ATP binding site [chemical binding]; other site 748727010967 Q-loop/lid; other site 748727010968 ABC transporter signature motif; other site 748727010969 Walker B; other site 748727010970 D-loop; other site 748727010971 H-loop/switch region; other site 748727010972 dihydroorotase; Validated; Region: pyrC; PRK09357 748727010973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727010974 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 748727010975 active site 748727010976 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 748727010977 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 748727010978 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 748727010979 Domain of unknown function DUF77; Region: DUF77; pfam01910 748727010980 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748727010981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727010982 active site 748727010983 phosphorylation site [posttranslational modification] 748727010984 intermolecular recognition site; other site 748727010985 dimerization interface [polypeptide binding]; other site 748727010986 LytTr DNA-binding domain; Region: LytTR; pfam04397 748727010987 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 748727010988 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 748727010989 Histidine kinase; Region: His_kinase; pfam06580 748727010990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727010991 ATP binding site [chemical binding]; other site 748727010992 Mg2+ binding site [ion binding]; other site 748727010993 G-X-G motif; other site 748727010994 Carbon starvation protein CstA; Region: CstA; pfam02554 748727010995 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 748727010996 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 748727010997 Carbon starvation protein CstA; Region: CstA; pfam02554 748727010998 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 748727010999 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 748727011000 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 748727011001 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 748727011002 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748727011003 Peptidase M16C associated; Region: M16C_assoc; pfam08367 748727011004 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 748727011005 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 748727011006 active site 748727011007 nucleophile elbow; other site 748727011008 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 748727011009 pyrroline-5-carboxylate reductase; Region: PLN02688 748727011010 pyruvate carboxylase; Reviewed; Region: PRK12999 748727011011 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727011012 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748727011013 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 748727011014 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 748727011015 active site 748727011016 catalytic residues [active] 748727011017 metal binding site [ion binding]; metal-binding site 748727011018 homodimer binding site [polypeptide binding]; other site 748727011019 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 748727011020 carboxyltransferase (CT) interaction site; other site 748727011021 biotinylation site [posttranslational modification]; other site 748727011022 UGMP family protein; Validated; Region: PRK09604 748727011023 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 748727011024 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 748727011025 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 748727011026 Walker A/P-loop; other site 748727011027 ATP binding site [chemical binding]; other site 748727011028 Q-loop/lid; other site 748727011029 ABC transporter signature motif; other site 748727011030 Walker B; other site 748727011031 D-loop; other site 748727011032 H-loop/switch region; other site 748727011033 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 748727011034 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 748727011035 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 748727011036 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 748727011037 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 748727011038 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 748727011039 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 748727011040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748727011041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748727011042 Predicted dehydrogenase [General function prediction only]; Region: COG0579 748727011043 hydroxyglutarate oxidase; Provisional; Region: PRK11728 748727011044 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 748727011045 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 748727011046 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 748727011047 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 748727011048 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 748727011049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748727011050 catalytic loop [active] 748727011051 iron binding site [ion binding]; other site 748727011052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727011053 nucleotide binding site [chemical binding]; other site 748727011054 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 748727011055 lipoyl attachment site [posttranslational modification]; other site 748727011056 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 748727011057 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727011058 ACS interaction site; other site 748727011059 CODH interaction site; other site 748727011060 metal cluster binding site [ion binding]; other site 748727011061 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 748727011062 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 748727011063 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 748727011064 substrate binding pocket [chemical binding]; other site 748727011065 dimer interface [polypeptide binding]; other site 748727011066 inhibitor binding site; inhibition site 748727011067 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 748727011068 Putative Fe-S cluster; Region: FeS; cl17515 748727011069 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 748727011070 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 748727011071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727011072 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 748727011073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727011074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727011075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748727011076 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 748727011077 FAD binding site [chemical binding]; other site 748727011078 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 748727011079 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 748727011080 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 748727011081 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 748727011082 homodimer interface [polypeptide binding]; other site 748727011083 NADP binding site [chemical binding]; other site 748727011084 substrate binding site [chemical binding]; other site 748727011085 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 748727011086 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 748727011087 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 748727011088 Potassium binding sites [ion binding]; other site 748727011089 Cesium cation binding sites [ion binding]; other site 748727011090 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 748727011091 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 748727011092 P-loop; other site 748727011093 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727011094 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 748727011095 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 748727011096 ACS interaction site; other site 748727011097 CODH interaction site; other site 748727011098 cubane metal cluster (B-cluster) [ion binding]; other site 748727011099 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 748727011100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 748727011101 Ligand Binding Site [chemical binding]; other site 748727011102 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 748727011103 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 748727011104 DNA binding residues [nucleotide binding] 748727011105 ferric uptake regulator; Provisional; Region: fur; PRK09462 748727011106 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748727011107 metal binding site 2 [ion binding]; metal-binding site 748727011108 putative DNA binding helix; other site 748727011109 metal binding site 1 [ion binding]; metal-binding site 748727011110 dimer interface [polypeptide binding]; other site 748727011111 structural Zn2+ binding site [ion binding]; other site 748727011112 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 748727011113 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 748727011114 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 748727011115 P loop nucleotide binding; other site 748727011116 switch II; other site 748727011117 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 748727011118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748727011119 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 748727011120 Predicted transcriptional regulators [Transcription]; Region: COG1733 748727011121 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748727011122 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 748727011123 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 748727011124 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 748727011125 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 748727011126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727011127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727011128 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 748727011129 putative dimerization interface [polypeptide binding]; other site 748727011130 Predicted membrane protein [Function unknown]; Region: COG2855 748727011131 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 748727011132 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 748727011133 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 748727011134 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748727011135 G3 box; other site 748727011136 Switch II region; other site 748727011137 G4 box; other site 748727011138 G5 box; other site 748727011139 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 748727011140 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 748727011141 TIGR03943 family protein; Region: TIGR03943 748727011142 Predicted permeases [General function prediction only]; Region: COG0701 748727011143 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 748727011144 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748727011145 metal binding site [ion binding]; metal-binding site 748727011146 Predicted permeases [General function prediction only]; Region: COG0701 748727011147 TIGR03943 family protein; Region: TIGR03943 748727011148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727011149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727011150 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 748727011151 putative dimerization interface [polypeptide binding]; other site 748727011152 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748727011153 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 748727011154 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748727011155 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 748727011156 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 748727011157 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 748727011158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727011159 Walker A/P-loop; other site 748727011160 ATP binding site [chemical binding]; other site 748727011161 Q-loop/lid; other site 748727011162 ABC transporter signature motif; other site 748727011163 Walker B; other site 748727011164 D-loop; other site 748727011165 H-loop/switch region; other site 748727011166 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 748727011167 Domain of unknown function (DUF364); Region: DUF364; pfam04016 748727011168 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 748727011169 Predicted membrane protein [Function unknown]; Region: COG2323 748727011170 Predicted membrane protein [Function unknown]; Region: COG2323 748727011171 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 748727011172 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 748727011173 putative metal binding site [ion binding]; other site 748727011174 MOSC domain; Region: MOSC; pfam03473 748727011175 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748727011176 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 748727011177 putative metal binding site [ion binding]; other site 748727011178 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748727011179 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748727011180 Walker A/P-loop; other site 748727011181 ATP binding site [chemical binding]; other site 748727011182 Q-loop/lid; other site 748727011183 ABC transporter signature motif; other site 748727011184 Walker B; other site 748727011185 D-loop; other site 748727011186 H-loop/switch region; other site 748727011187 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748727011188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748727011189 ABC-ATPase subunit interface; other site 748727011190 dimer interface [polypeptide binding]; other site 748727011191 putative PBP binding regions; other site 748727011192 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748727011193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727011194 S-adenosylmethionine binding site [chemical binding]; other site 748727011195 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 748727011196 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 748727011197 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 748727011198 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 748727011199 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 748727011200 dimerization interface [polypeptide binding]; other site 748727011201 active site 748727011202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727011203 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 748727011204 Walker A/P-loop; other site 748727011205 ATP binding site [chemical binding]; other site 748727011206 Q-loop/lid; other site 748727011207 ABC transporter signature motif; other site 748727011208 Walker B; other site 748727011209 D-loop; other site 748727011210 H-loop/switch region; other site 748727011211 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 748727011212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748727011213 dimer interface [polypeptide binding]; other site 748727011214 conserved gate region; other site 748727011215 putative PBP binding loops; other site 748727011216 ABC-ATPase subunit interface; other site 748727011217 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 748727011218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748727011219 substrate binding pocket [chemical binding]; other site 748727011220 membrane-bound complex binding site; other site 748727011221 hinge residues; other site 748727011222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727011223 Zn2+ binding site [ion binding]; other site 748727011224 Mg2+ binding site [ion binding]; other site 748727011225 AAA domain; Region: AAA_17; cl17253 748727011226 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748727011227 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748727011228 intersubunit interface [polypeptide binding]; other site 748727011229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727011230 Zn2+ binding site [ion binding]; other site 748727011231 Mg2+ binding site [ion binding]; other site 748727011232 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748727011233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727011234 Zn2+ binding site [ion binding]; other site 748727011235 Mg2+ binding site [ion binding]; other site 748727011236 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 748727011237 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 748727011238 Glycoprotease family; Region: Peptidase_M22; pfam00814 748727011239 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 748727011240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727011241 Coenzyme A binding pocket [chemical binding]; other site 748727011242 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 748727011243 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 748727011244 active site 748727011245 HIGH motif; other site 748727011246 dimer interface [polypeptide binding]; other site 748727011247 KMSKS motif; other site 748727011248 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727011249 RNA binding surface [nucleotide binding]; other site 748727011250 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 748727011251 Divergent AAA domain; Region: AAA_4; pfam04326 748727011252 Probable zinc-binding domain; Region: zf-trcl; pfam13451 748727011253 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 748727011254 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 748727011255 active site 748727011256 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748727011257 sugar phosphate phosphatase; Provisional; Region: PRK10513 748727011258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727011259 active site 748727011260 motif I; other site 748727011261 motif II; other site 748727011262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748727011263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748727011264 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 748727011265 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 748727011266 G1 box; other site 748727011267 putative GEF interaction site [polypeptide binding]; other site 748727011268 GTP/Mg2+ binding site [chemical binding]; other site 748727011269 Switch I region; other site 748727011270 G2 box; other site 748727011271 G3 box; other site 748727011272 Switch II region; other site 748727011273 G4 box; other site 748727011274 G5 box; other site 748727011275 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 748727011276 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 748727011277 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 748727011278 active site 748727011279 HIGH motif; other site 748727011280 dimer interface [polypeptide binding]; other site 748727011281 KMSKS motif; other site 748727011282 Putative glucoamylase; Region: Glycoamylase; pfam10091 748727011283 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 748727011284 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 748727011285 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 748727011286 diaminopimelate decarboxylase; Region: lysA; TIGR01048 748727011287 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 748727011288 active site 748727011289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748727011290 substrate binding site [chemical binding]; other site 748727011291 catalytic residues [active] 748727011292 dimer interface [polypeptide binding]; other site 748727011293 aspartate kinase; Reviewed; Region: PRK06635 748727011294 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 748727011295 putative nucleotide binding site [chemical binding]; other site 748727011296 putative catalytic residues [active] 748727011297 putative Mg ion binding site [ion binding]; other site 748727011298 putative aspartate binding site [chemical binding]; other site 748727011299 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 748727011300 putative allosteric regulatory site; other site 748727011301 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 748727011302 putative allosteric regulatory residue; other site 748727011303 biotin synthase; Provisional; Region: PRK07094 748727011304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727011305 FeS/SAM binding site; other site 748727011306 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 748727011307 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 748727011308 Part of AAA domain; Region: AAA_19; pfam13245 748727011309 Family description; Region: UvrD_C_2; pfam13538 748727011310 FtsH Extracellular; Region: FtsH_ext; pfam06480 748727011311 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 748727011312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727011313 Walker A motif; other site 748727011314 ATP binding site [chemical binding]; other site 748727011315 Walker B motif; other site 748727011316 arginine finger; other site 748727011317 Peptidase family M41; Region: Peptidase_M41; pfam01434 748727011318 prolyl-tRNA synthetase; Provisional; Region: PRK08661 748727011319 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 748727011320 dimer interface [polypeptide binding]; other site 748727011321 motif 1; other site 748727011322 active site 748727011323 motif 2; other site 748727011324 motif 3; other site 748727011325 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 748727011326 anticodon binding site; other site 748727011327 zinc-binding site [ion binding]; other site 748727011328 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 748727011329 glycerate kinase; Region: TIGR00045 748727011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727011331 D-galactonate transporter; Region: 2A0114; TIGR00893 748727011332 putative substrate translocation pore; other site 748727011333 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 748727011334 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 748727011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 748727011336 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727011337 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727011338 NodB motif; other site 748727011339 active site 748727011340 catalytic site [active] 748727011341 Zn binding site [ion binding]; other site 748727011342 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 748727011343 active site 748727011344 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 748727011345 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 748727011346 Malic enzyme, N-terminal domain; Region: malic; pfam00390 748727011347 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 748727011348 putative NAD(P) binding site [chemical binding]; other site 748727011349 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 748727011350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011351 active site 748727011352 phosphorylation site [posttranslational modification] 748727011353 intermolecular recognition site; other site 748727011354 dimerization interface [polypeptide binding]; other site 748727011355 sensory histidine kinase DcuS; Provisional; Region: PRK11086 748727011356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011357 ATP binding site [chemical binding]; other site 748727011358 Mg2+ binding site [ion binding]; other site 748727011359 G-X-G motif; other site 748727011360 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 748727011361 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 748727011362 B3/4 domain; Region: B3_4; pfam03483 748727011363 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 748727011364 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 748727011365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748727011366 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748727011367 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748727011368 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727011369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727011370 non-specific DNA binding site [nucleotide binding]; other site 748727011371 salt bridge; other site 748727011372 sequence-specific DNA binding site [nucleotide binding]; other site 748727011373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727011374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727011375 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727011376 dimerization interface [polypeptide binding]; other site 748727011377 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 748727011378 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 748727011379 catalytic Zn binding site [ion binding]; other site 748727011380 NAD binding site [chemical binding]; other site 748727011381 structural Zn binding site [ion binding]; other site 748727011382 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 748727011383 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 748727011384 active site 748727011385 FMN binding site [chemical binding]; other site 748727011386 substrate binding site [chemical binding]; other site 748727011387 putative catalytic residue [active] 748727011388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727011389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748727011390 phosphoenolpyruvate synthase; Validated; Region: PRK06241 748727011391 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 748727011392 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748727011393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727011394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727011395 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727011396 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727011397 Walker A/P-loop; other site 748727011398 ATP binding site [chemical binding]; other site 748727011399 Q-loop/lid; other site 748727011400 ABC transporter signature motif; other site 748727011401 Walker B; other site 748727011402 D-loop; other site 748727011403 H-loop/switch region; other site 748727011404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727011405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011406 ATP binding site [chemical binding]; other site 748727011407 Mg2+ binding site [ion binding]; other site 748727011408 G-X-G motif; other site 748727011409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727011410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011411 active site 748727011412 phosphorylation site [posttranslational modification] 748727011413 intermolecular recognition site; other site 748727011414 dimerization interface [polypeptide binding]; other site 748727011415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727011416 DNA binding site [nucleotide binding] 748727011417 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748727011418 Beta-lactamase; Region: Beta-lactamase; pfam00144 748727011419 Beta-lactamase; Region: Beta-lactamase; pfam00144 748727011420 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748727011421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727011422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011423 active site 748727011424 phosphorylation site [posttranslational modification] 748727011425 intermolecular recognition site; other site 748727011426 dimerization interface [polypeptide binding]; other site 748727011427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727011428 DNA binding site [nucleotide binding] 748727011429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727011430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727011431 dimerization interface [polypeptide binding]; other site 748727011432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727011433 dimer interface [polypeptide binding]; other site 748727011434 phosphorylation site [posttranslational modification] 748727011435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011436 ATP binding site [chemical binding]; other site 748727011437 Mg2+ binding site [ion binding]; other site 748727011438 G-X-G motif; other site 748727011439 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 748727011440 active site 748727011441 catalytic triad [active] 748727011442 oxyanion hole [active] 748727011443 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 748727011444 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748727011445 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 748727011446 CHASE3 domain; Region: CHASE3; pfam05227 748727011447 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748727011448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727011449 dimerization interface [polypeptide binding]; other site 748727011450 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727011451 dimer interface [polypeptide binding]; other site 748727011452 putative CheW interface [polypeptide binding]; other site 748727011453 potential frameshift: common BLAST hit: gi|150019802|ref|YP_001312056.1| transposase 748727011454 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 748727011455 Predicted transcriptional regulators [Transcription]; Region: COG1695 748727011456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748727011457 putative DNA binding site [nucleotide binding]; other site 748727011458 putative Zn2+ binding site [ion binding]; other site 748727011459 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 748727011460 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 748727011461 FMN binding site [chemical binding]; other site 748727011462 active site 748727011463 catalytic residues [active] 748727011464 substrate binding site [chemical binding]; other site 748727011465 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 748727011466 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 748727011467 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748727011468 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748727011469 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748727011470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748727011471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748727011472 metal binding site [ion binding]; metal-binding site 748727011473 active site 748727011474 I-site; other site 748727011475 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727011476 Spore germination protein; Region: Spore_permease; cl17796 748727011477 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727011478 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727011479 Predicted membrane protein [Function unknown]; Region: COG2246 748727011480 GtrA-like protein; Region: GtrA; pfam04138 748727011481 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 748727011482 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 748727011483 Ligand binding site; other site 748727011484 Putative Catalytic site; other site 748727011485 DXD motif; other site 748727011486 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 748727011487 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 748727011488 acetolactate synthase; Reviewed; Region: PRK08322 748727011489 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 748727011490 PYR/PP interface [polypeptide binding]; other site 748727011491 dimer interface [polypeptide binding]; other site 748727011492 TPP binding site [chemical binding]; other site 748727011493 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748727011494 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 748727011495 TPP-binding site [chemical binding]; other site 748727011496 dimer interface [polypeptide binding]; other site 748727011497 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727011498 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 748727011499 active site 748727011500 NAD binding site [chemical binding]; other site 748727011501 metal binding site [ion binding]; metal-binding site 748727011502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727011503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727011504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727011505 dimerization interface [polypeptide binding]; other site 748727011506 short chain dehydrogenase; Provisional; Region: PRK06138 748727011507 classical (c) SDRs; Region: SDR_c; cd05233 748727011508 NAD(P) binding site [chemical binding]; other site 748727011509 active site 748727011510 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727011511 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727011512 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727011513 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727011514 Spore germination protein; Region: Spore_permease; cl17796 748727011515 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748727011516 MarR family; Region: MarR_2; cl17246 748727011517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748727011518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748727011519 Coenzyme A binding pocket [chemical binding]; other site 748727011520 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 748727011521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748727011522 Zn2+ binding site [ion binding]; other site 748727011523 Mg2+ binding site [ion binding]; other site 748727011524 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748727011525 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748727011526 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748727011527 Spore germination protein; Region: Spore_permease; cl17796 748727011528 Spore germination protein; Region: Spore_permease; cl17796 748727011529 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 748727011530 SmpB-tmRNA interface; other site 748727011531 ribonuclease R; Region: RNase_R; TIGR02063 748727011532 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 748727011533 RNA binding site [nucleotide binding]; other site 748727011534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 748727011535 RNB domain; Region: RNB; pfam00773 748727011536 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 748727011537 RNA binding site [nucleotide binding]; other site 748727011538 Preprotein translocase SecG subunit; Region: SecG; pfam03840 748727011539 enolase; Provisional; Region: eno; PRK00077 748727011540 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 748727011541 dimer interface [polypeptide binding]; other site 748727011542 metal binding site [ion binding]; metal-binding site 748727011543 substrate binding pocket [chemical binding]; other site 748727011544 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 748727011545 phosphoglyceromutase; Provisional; Region: PRK05434 748727011546 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 748727011547 triosephosphate isomerase; Provisional; Region: PRK14565 748727011548 substrate binding site [chemical binding]; other site 748727011549 dimer interface [polypeptide binding]; other site 748727011550 catalytic triad [active] 748727011551 Phosphoglycerate kinase; Region: PGK; pfam00162 748727011552 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 748727011553 substrate binding site [chemical binding]; other site 748727011554 hinge regions; other site 748727011555 ADP binding site [chemical binding]; other site 748727011556 catalytic site [active] 748727011557 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 748727011558 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 748727011559 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 748727011560 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748727011561 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748727011562 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 748727011563 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 748727011564 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 748727011565 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 748727011566 EDD domain protein, DegV family; Region: DegV; TIGR00762 748727011567 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748727011568 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 748727011569 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748727011570 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748727011571 active site 748727011572 metal binding site [ion binding]; metal-binding site 748727011573 Uncharacterized conserved protein [Function unknown]; Region: COG5663 748727011574 EamA-like transporter family; Region: EamA; pfam00892 748727011575 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 748727011576 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748727011577 VanW like protein; Region: VanW; pfam04294 748727011578 competence damage-inducible protein A; Provisional; Region: PRK00549 748727011579 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 748727011580 putative MPT binding site; other site 748727011581 Competence-damaged protein; Region: CinA; pfam02464 748727011582 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 748727011583 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 748727011584 minor groove reading motif; other site 748727011585 helix-hairpin-helix signature motif; other site 748727011586 substrate binding pocket [chemical binding]; other site 748727011587 active site 748727011588 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 748727011589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 748727011590 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748727011591 putative acyl-acceptor binding pocket; other site 748727011592 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 748727011593 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 748727011594 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 748727011595 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 748727011596 trimer interface [polypeptide binding]; other site 748727011597 active site 748727011598 substrate binding site [chemical binding]; other site 748727011599 CoA binding site [chemical binding]; other site 748727011600 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 748727011601 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 748727011602 dimer interface [polypeptide binding]; other site 748727011603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727011604 catalytic residue [active] 748727011605 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 748727011606 Bacterial Ig-like domain; Region: Big_5; pfam13205 748727011607 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 748727011608 Rubredoxin [Energy production and conversion]; Region: COG1773 748727011609 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 748727011610 iron binding site [ion binding]; other site 748727011611 Rubrerythrin [Energy production and conversion]; Region: COG1592 748727011612 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 748727011613 diiron binding motif [ion binding]; other site 748727011614 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 748727011615 active site 2 [active] 748727011616 active site 1 [active] 748727011617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727011618 D-galactonate transporter; Region: 2A0114; TIGR00893 748727011619 putative substrate translocation pore; other site 748727011620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727011621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727011622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 748727011623 dimerization interface [polypeptide binding]; other site 748727011624 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 748727011625 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 748727011626 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 748727011627 acyl-activating enzyme (AAE) consensus motif; other site 748727011628 putative AMP binding site [chemical binding]; other site 748727011629 putative active site [active] 748727011630 putative CoA binding site [chemical binding]; other site 748727011631 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 748727011632 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 748727011633 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 748727011634 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 748727011635 Ligand binding site [chemical binding]; other site 748727011636 Electron transfer flavoprotein domain; Region: ETF; pfam01012 748727011637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 748727011638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 748727011639 active site 748727011640 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 748727011641 CoA-transferase family III; Region: CoA_transf_3; pfam02515 748727011642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 748727011643 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 748727011644 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 748727011645 active site 748727011646 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 748727011647 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 748727011648 Uncharacterized conserved protein [Function unknown]; Region: COG1633 748727011649 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 748727011650 dinuclear metal binding motif [ion binding]; other site 748727011651 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 748727011652 tartrate dehydrogenase; Region: TTC; TIGR02089 748727011653 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727011654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011655 active site 748727011656 phosphorylation site [posttranslational modification] 748727011657 intermolecular recognition site; other site 748727011658 dimerization interface [polypeptide binding]; other site 748727011659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727011660 DNA binding site [nucleotide binding] 748727011661 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 748727011662 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 748727011663 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 748727011664 Ligand Binding Site [chemical binding]; other site 748727011665 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 748727011666 GAF domain; Region: GAF_3; pfam13492 748727011667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727011668 phosphorylation site [posttranslational modification] 748727011669 dimer interface [polypeptide binding]; other site 748727011670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011671 ATP binding site [chemical binding]; other site 748727011672 Mg2+ binding site [ion binding]; other site 748727011673 G-X-G motif; other site 748727011674 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 748727011675 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 748727011676 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748727011677 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748727011678 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 748727011679 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748727011680 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 748727011681 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 748727011682 active site 748727011683 multimer interface [polypeptide binding]; other site 748727011684 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 748727011685 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 748727011686 predicted active site [active] 748727011687 catalytic triad [active] 748727011688 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727011689 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748727011690 TM-ABC transporter signature motif; other site 748727011691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748727011692 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748727011693 TM-ABC transporter signature motif; other site 748727011694 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 748727011695 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748727011696 Walker A/P-loop; other site 748727011697 ATP binding site [chemical binding]; other site 748727011698 Q-loop/lid; other site 748727011699 ABC transporter signature motif; other site 748727011700 Walker B; other site 748727011701 D-loop; other site 748727011702 H-loop/switch region; other site 748727011703 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748727011704 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 748727011705 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 748727011706 putative ligand binding site [chemical binding]; other site 748727011707 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 748727011708 active site 748727011709 intersubunit interactions; other site 748727011710 catalytic residue [active] 748727011711 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 748727011712 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 748727011713 Phosphotransferase enzyme family; Region: APH; pfam01636 748727011714 active site 748727011715 ATP binding site [chemical binding]; other site 748727011716 substrate binding site [chemical binding]; other site 748727011717 dimer interface [polypeptide binding]; other site 748727011718 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727011719 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 748727011720 putative active site [active] 748727011721 metal binding site [ion binding]; metal-binding site 748727011722 Histidine kinase; Region: His_kinase; pfam06580 748727011723 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 748727011724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011725 ATP binding site [chemical binding]; other site 748727011726 Mg2+ binding site [ion binding]; other site 748727011727 G-X-G motif; other site 748727011728 Response regulator receiver domain; Region: Response_reg; pfam00072 748727011729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011730 active site 748727011731 phosphorylation site [posttranslational modification] 748727011732 intermolecular recognition site; other site 748727011733 dimerization interface [polypeptide binding]; other site 748727011734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727011735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748727011736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748727011737 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727011738 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 748727011739 Hexamer interface [polypeptide binding]; other site 748727011740 Putative hexagonal pore residue; other site 748727011741 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727011742 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 748727011743 Hexamer interface [polypeptide binding]; other site 748727011744 Putative hexagonal pore residue; other site 748727011745 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 748727011746 Propanediol utilisation protein PduL; Region: PduL; pfam06130 748727011747 Propanediol utilisation protein PduL; Region: PduL; pfam06130 748727011748 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 748727011749 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748727011750 putative catalytic cysteine [active] 748727011751 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727011752 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 748727011753 Hexamer interface [polypeptide binding]; other site 748727011754 Hexagonal pore residue; other site 748727011755 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 748727011756 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 748727011757 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 748727011758 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 748727011759 putative hexamer interface [polypeptide binding]; other site 748727011760 putative hexagonal pore; other site 748727011761 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 748727011762 putative hexamer interface [polypeptide binding]; other site 748727011763 putative hexagonal pore; other site 748727011764 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 748727011765 SLBB domain; Region: SLBB; pfam10531 748727011766 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 748727011767 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 748727011768 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 748727011769 Hexamer/Pentamer interface [polypeptide binding]; other site 748727011770 central pore; other site 748727011771 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 748727011772 Hexamer interface [polypeptide binding]; other site 748727011773 Hexagonal pore residue; other site 748727011774 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 748727011775 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727011776 nucleotide binding site [chemical binding]; other site 748727011777 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748727011778 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 748727011779 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 748727011780 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748727011781 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 748727011782 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 748727011783 dimer interface [polypeptide binding]; other site 748727011784 active site 748727011785 glycine loop; other site 748727011786 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748727011787 putative catalytic cysteine [active] 748727011788 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 748727011789 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727011790 Hexamer interface [polypeptide binding]; other site 748727011791 Hexagonal pore residue; other site 748727011792 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 748727011793 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 748727011794 Hexamer interface [polypeptide binding]; other site 748727011795 Hexagonal pore residue; other site 748727011796 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748727011797 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 748727011798 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 748727011799 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 748727011800 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748727011801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727011802 DNA-binding site [nucleotide binding]; DNA binding site 748727011803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748727011804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748727011805 homodimer interface [polypeptide binding]; other site 748727011806 catalytic residue [active] 748727011807 LysE type translocator; Region: LysE; cl00565 748727011808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727011809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748727011810 putative substrate translocation pore; other site 748727011811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748727011812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748727011813 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748727011814 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 748727011815 putative active site [active] 748727011816 metal binding site [ion binding]; metal-binding site 748727011817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748727011818 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748727011819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727011820 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 748727011821 dimer interface [polypeptide binding]; other site 748727011822 phosphorylation site [posttranslational modification] 748727011823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011824 ATP binding site [chemical binding]; other site 748727011825 Mg2+ binding site [ion binding]; other site 748727011826 G-X-G motif; other site 748727011827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727011828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011829 active site 748727011830 phosphorylation site [posttranslational modification] 748727011831 intermolecular recognition site; other site 748727011832 dimerization interface [polypeptide binding]; other site 748727011833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727011834 DNA binding site [nucleotide binding] 748727011835 FtsX-like permease family; Region: FtsX; pfam02687 748727011836 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748727011837 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748727011838 Walker A/P-loop; other site 748727011839 ATP binding site [chemical binding]; other site 748727011840 Q-loop/lid; other site 748727011841 ABC transporter signature motif; other site 748727011842 Walker B; other site 748727011843 D-loop; other site 748727011844 H-loop/switch region; other site 748727011845 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 748727011846 Putative amidase domain; Region: Amidase_6; pfam12671 748727011847 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 748727011848 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 748727011849 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748727011850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727011851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748727011852 Walker A/P-loop; other site 748727011853 ATP binding site [chemical binding]; other site 748727011854 Q-loop/lid; other site 748727011855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727011856 ABC transporter signature motif; other site 748727011857 ABC transporter; Region: ABC_tran_2; pfam12848 748727011858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748727011859 Mor transcription activator family; Region: Mor; cl02360 748727011860 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748727011861 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748727011862 DNA binding residues [nucleotide binding] 748727011863 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727011864 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748727011865 DNA binding residues [nucleotide binding] 748727011866 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 748727011867 Peptidase family M28; Region: Peptidase_M28; pfam04389 748727011868 metal binding site [ion binding]; metal-binding site 748727011869 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 748727011870 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748727011871 DNA binding residues [nucleotide binding] 748727011872 drug binding residues [chemical binding]; other site 748727011873 dimer interface [polypeptide binding]; other site 748727011874 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 748727011875 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748727011876 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748727011877 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727011878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727011879 non-specific DNA binding site [nucleotide binding]; other site 748727011880 salt bridge; other site 748727011881 sequence-specific DNA binding site [nucleotide binding]; other site 748727011882 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 748727011883 Flavoprotein; Region: Flavoprotein; pfam02441 748727011884 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748727011885 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 748727011886 NodB motif; other site 748727011887 active site 748727011888 catalytic site [active] 748727011889 Zn binding site [ion binding]; other site 748727011890 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 748727011891 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748727011892 active site 748727011893 metal binding site [ion binding]; metal-binding site 748727011894 amino acid transporter; Region: 2A0306; TIGR00909 748727011895 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 748727011896 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 748727011897 oxidoreductase; Provisional; Region: PRK10015 748727011898 4Fe-4S binding domain; Region: Fer4; pfam00037 748727011899 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748727011900 4Fe-4S binding domain; Region: Fer4; pfam00037 748727011901 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 748727011902 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 748727011903 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 748727011904 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 748727011905 Ligand binding site [chemical binding]; other site 748727011906 Electron transfer flavoprotein domain; Region: ETF; pfam01012 748727011907 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748727011908 metal-binding site [ion binding] 748727011909 Uncharacterized conserved protein [Function unknown]; Region: COG2836 748727011910 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 748727011911 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 748727011912 OsmC-like protein; Region: OsmC; pfam02566 748727011913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727011914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727011915 dimer interface [polypeptide binding]; other site 748727011916 phosphorylation site [posttranslational modification] 748727011917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727011918 ATP binding site [chemical binding]; other site 748727011919 Mg2+ binding site [ion binding]; other site 748727011920 G-X-G motif; other site 748727011921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727011922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727011923 active site 748727011924 phosphorylation site [posttranslational modification] 748727011925 intermolecular recognition site; other site 748727011926 dimerization interface [polypeptide binding]; other site 748727011927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727011928 DNA binding site [nucleotide binding] 748727011929 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 748727011930 UbiA prenyltransferase family; Region: UbiA; pfam01040 748727011931 CAAX protease self-immunity; Region: Abi; pfam02517 748727011932 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 748727011933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727011934 S-adenosylmethionine binding site [chemical binding]; other site 748727011935 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748727011936 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748727011937 substrate binding pocket [chemical binding]; other site 748727011938 chain length determination region; other site 748727011939 substrate-Mg2+ binding site; other site 748727011940 catalytic residues [active] 748727011941 aspartate-rich region 1; other site 748727011942 active site lid residues [active] 748727011943 aspartate-rich region 2; other site 748727011944 YtkA-like; Region: YtkA; pfam13115 748727011945 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748727011946 UPF0126 domain; Region: UPF0126; pfam03458 748727011947 Predicted membrane protein [Function unknown]; Region: COG2860 748727011948 UPF0126 domain; Region: UPF0126; pfam03458 748727011949 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 748727011950 threonine synthase; Validated; Region: PRK06260 748727011951 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 748727011952 iron binding site [ion binding]; other site 748727011953 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 748727011954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748727011955 catalytic residue [active] 748727011956 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 748727011957 homotrimer interaction site [polypeptide binding]; other site 748727011958 putative active site [active] 748727011959 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727011960 alanine racemase; Reviewed; Region: alr; PRK00053 748727011961 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 748727011962 active site 748727011963 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748727011964 dimer interface [polypeptide binding]; other site 748727011965 substrate binding site [chemical binding]; other site 748727011966 catalytic residues [active] 748727011967 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 748727011968 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748727011969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748727011970 putative active site [active] 748727011971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727011972 Walker A motif; other site 748727011973 ATP binding site [chemical binding]; other site 748727011974 Walker B motif; other site 748727011975 arginine finger; other site 748727011976 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 748727011977 DNA-binding interface [nucleotide binding]; DNA binding site 748727011978 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 748727011979 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 748727011980 glutaminase active site [active] 748727011981 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 748727011982 dimer interface [polypeptide binding]; other site 748727011983 active site 748727011984 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 748727011985 dimer interface [polypeptide binding]; other site 748727011986 active site 748727011987 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 748727011988 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 748727011989 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 748727011990 active site 748727011991 substrate binding site [chemical binding]; other site 748727011992 metal binding site [ion binding]; metal-binding site 748727011993 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 748727011994 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 748727011995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 748727011996 YbbR-like protein; Region: YbbR; pfam07949 748727011997 YbbR-like protein; Region: YbbR; pfam07949 748727011998 Uncharacterized conserved protein [Function unknown]; Region: COG1624 748727011999 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 748727012000 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748727012001 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 748727012002 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748727012003 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748727012004 catalytic residues [active] 748727012005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748727012006 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 748727012007 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 748727012008 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748727012009 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 748727012010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748727012011 TPR motif; other site 748727012012 binding surface 748727012013 TPR repeat; Region: TPR_11; pfam13414 748727012014 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 748727012015 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748727012016 active site 748727012017 nucleotide binding site [chemical binding]; other site 748727012018 HIGH motif; other site 748727012019 KMSKS motif; other site 748727012020 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 748727012021 Coenzyme A transferase; Region: CoA_trans; cl17247 748727012022 Coenzyme A transferase; Region: CoA_trans; cl17247 748727012023 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 748727012024 citrate lyase subunit gamma; Provisional; Region: PRK13253 748727012025 fumarate hydratase; Provisional; Region: PRK06842 748727012026 fumarate hydratase; Provisional; Region: PRK06246 748727012027 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 748727012028 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 748727012029 dimer interface [polypeptide binding]; other site 748727012030 active site 748727012031 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 748727012032 substrate binding site [chemical binding]; other site 748727012033 B12 cofactor binding site [chemical binding]; other site 748727012034 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 748727012035 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 748727012036 conserved hypothetical protein; Region: glmL_fam; TIGR01319 748727012037 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 748727012038 B12 binding site [chemical binding]; other site 748727012039 heterodimer interface [polypeptide binding]; other site 748727012040 cobalt ligand [ion binding]; other site 748727012041 Predicted transcriptional regulators [Transcription]; Region: COG1725 748727012042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748727012043 DNA-binding site [nucleotide binding]; DNA binding site 748727012044 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748727012045 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748727012046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012047 Walker A motif; other site 748727012048 ATP binding site [chemical binding]; other site 748727012049 Walker B motif; other site 748727012050 arginine finger; other site 748727012051 HTH domain; Region: HTH_11; pfam08279 748727012052 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 748727012053 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 748727012054 catalytic triad [active] 748727012055 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748727012056 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748727012057 active site 748727012058 metal binding site [ion binding]; metal-binding site 748727012059 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 748727012060 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 748727012061 23S rRNA interface [nucleotide binding]; other site 748727012062 L3 interface [polypeptide binding]; other site 748727012063 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 748727012064 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 748727012065 dimerization interface 3.5A [polypeptide binding]; other site 748727012066 active site 748727012067 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748727012068 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 748727012069 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727012070 Walker A/P-loop; other site 748727012071 ATP binding site [chemical binding]; other site 748727012072 Q-loop/lid; other site 748727012073 ABC transporter signature motif; other site 748727012074 Walker B; other site 748727012075 D-loop; other site 748727012076 H-loop/switch region; other site 748727012077 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 748727012078 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748727012079 Walker A/P-loop; other site 748727012080 ATP binding site [chemical binding]; other site 748727012081 Q-loop/lid; other site 748727012082 ABC transporter signature motif; other site 748727012083 Walker B; other site 748727012084 D-loop; other site 748727012085 H-loop/switch region; other site 748727012086 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 748727012087 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 748727012088 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 748727012089 alphaNTD - beta interaction site [polypeptide binding]; other site 748727012090 alphaNTD homodimer interface [polypeptide binding]; other site 748727012091 alphaNTD - beta' interaction site [polypeptide binding]; other site 748727012092 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 748727012093 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 748727012094 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 748727012095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727012096 RNA binding surface [nucleotide binding]; other site 748727012097 30S ribosomal protein S11; Validated; Region: PRK05309 748727012098 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 748727012099 30S ribosomal protein S13; Region: bact_S13; TIGR03631 748727012100 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 748727012101 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 748727012102 rRNA binding site [nucleotide binding]; other site 748727012103 predicted 30S ribosome binding site; other site 748727012104 adenylate kinase; Reviewed; Region: adk; PRK00279 748727012105 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 748727012106 AMP-binding site [chemical binding]; other site 748727012107 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 748727012108 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 748727012109 SecY translocase; Region: SecY; pfam00344 748727012110 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 748727012111 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 748727012112 23S rRNA binding site [nucleotide binding]; other site 748727012113 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 748727012114 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 748727012115 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 748727012116 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 748727012117 23S rRNA interface [nucleotide binding]; other site 748727012118 5S rRNA interface [nucleotide binding]; other site 748727012119 L27 interface [polypeptide binding]; other site 748727012120 L5 interface [polypeptide binding]; other site 748727012121 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 748727012122 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748727012123 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748727012124 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 748727012125 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 748727012126 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 748727012127 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 748727012128 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 748727012129 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 748727012130 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 748727012131 RNA binding site [nucleotide binding]; other site 748727012132 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 748727012133 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 748727012134 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 748727012135 23S rRNA interface [nucleotide binding]; other site 748727012136 putative translocon interaction site; other site 748727012137 signal recognition particle (SRP54) interaction site; other site 748727012138 L23 interface [polypeptide binding]; other site 748727012139 trigger factor interaction site; other site 748727012140 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 748727012141 23S rRNA interface [nucleotide binding]; other site 748727012142 5S rRNA interface [nucleotide binding]; other site 748727012143 putative antibiotic binding site [chemical binding]; other site 748727012144 L25 interface [polypeptide binding]; other site 748727012145 L27 interface [polypeptide binding]; other site 748727012146 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 748727012147 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 748727012148 G-X-X-G motif; other site 748727012149 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 748727012150 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 748727012151 putative translocon binding site; other site 748727012152 protein-rRNA interface [nucleotide binding]; other site 748727012153 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 748727012154 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 748727012155 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 748727012156 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 748727012157 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 748727012158 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 748727012159 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 748727012160 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 748727012161 elongation factor Tu; Reviewed; Region: PRK00049 748727012162 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 748727012163 G1 box; other site 748727012164 GEF interaction site [polypeptide binding]; other site 748727012165 GTP/Mg2+ binding site [chemical binding]; other site 748727012166 Switch I region; other site 748727012167 G2 box; other site 748727012168 G3 box; other site 748727012169 Switch II region; other site 748727012170 G4 box; other site 748727012171 G5 box; other site 748727012172 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 748727012173 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 748727012174 Antibiotic Binding Site [chemical binding]; other site 748727012175 elongation factor G; Reviewed; Region: PRK00007 748727012176 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 748727012177 G1 box; other site 748727012178 putative GEF interaction site [polypeptide binding]; other site 748727012179 GTP/Mg2+ binding site [chemical binding]; other site 748727012180 Switch I region; other site 748727012181 G2 box; other site 748727012182 G3 box; other site 748727012183 Switch II region; other site 748727012184 G4 box; other site 748727012185 G5 box; other site 748727012186 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 748727012187 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 748727012188 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 748727012189 30S ribosomal protein S7; Validated; Region: PRK05302 748727012190 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 748727012191 S17 interaction site [polypeptide binding]; other site 748727012192 S8 interaction site; other site 748727012193 16S rRNA interaction site [nucleotide binding]; other site 748727012194 streptomycin interaction site [chemical binding]; other site 748727012195 23S rRNA interaction site [nucleotide binding]; other site 748727012196 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 748727012197 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 748727012198 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 748727012199 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 748727012200 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 748727012201 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 748727012202 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 748727012203 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 748727012204 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 748727012205 G-loop; other site 748727012206 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 748727012207 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 748727012208 DNA binding site [nucleotide binding] 748727012209 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 748727012210 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 748727012211 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 748727012212 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 748727012213 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 748727012214 RPB1 interaction site [polypeptide binding]; other site 748727012215 RPB10 interaction site [polypeptide binding]; other site 748727012216 RPB11 interaction site [polypeptide binding]; other site 748727012217 RPB3 interaction site [polypeptide binding]; other site 748727012218 RPB12 interaction site [polypeptide binding]; other site 748727012219 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 748727012220 core dimer interface [polypeptide binding]; other site 748727012221 peripheral dimer interface [polypeptide binding]; other site 748727012222 L10 interface [polypeptide binding]; other site 748727012223 L11 interface [polypeptide binding]; other site 748727012224 putative EF-Tu interaction site [polypeptide binding]; other site 748727012225 putative EF-G interaction site [polypeptide binding]; other site 748727012226 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 748727012227 23S rRNA interface [nucleotide binding]; other site 748727012228 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 748727012229 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 748727012230 mRNA/rRNA interface [nucleotide binding]; other site 748727012231 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 748727012232 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 748727012233 23S rRNA interface [nucleotide binding]; other site 748727012234 L7/L12 interface [polypeptide binding]; other site 748727012235 putative thiostrepton binding site; other site 748727012236 L25 interface [polypeptide binding]; other site 748727012237 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 748727012238 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 748727012239 putative homodimer interface [polypeptide binding]; other site 748727012240 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 748727012241 heterodimer interface [polypeptide binding]; other site 748727012242 homodimer interface [polypeptide binding]; other site 748727012243 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 748727012244 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 748727012245 elongation factor Tu; Reviewed; Region: PRK00049 748727012246 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 748727012247 G1 box; other site 748727012248 GEF interaction site [polypeptide binding]; other site 748727012249 GTP/Mg2+ binding site [chemical binding]; other site 748727012250 Switch I region; other site 748727012251 G2 box; other site 748727012252 G3 box; other site 748727012253 Switch II region; other site 748727012254 G4 box; other site 748727012255 G5 box; other site 748727012256 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 748727012257 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 748727012258 Antibiotic Binding Site [chemical binding]; other site 748727012259 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 748727012260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748727012261 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748727012262 YacP-like NYN domain; Region: NYN_YacP; pfam05991 748727012263 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 748727012264 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 748727012265 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748727012266 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 748727012267 dimerization interface [polypeptide binding]; other site 748727012268 active site 748727012269 metal binding site [ion binding]; metal-binding site 748727012270 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 748727012271 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748727012272 active site 748727012273 HIGH motif; other site 748727012274 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748727012275 KMSKS motif; other site 748727012276 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 748727012277 tRNA binding surface [nucleotide binding]; other site 748727012278 anticodon binding site; other site 748727012279 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 748727012280 substrate binding site; other site 748727012281 dimer interface; other site 748727012282 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 748727012283 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 748727012284 putative active site [active] 748727012285 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 748727012286 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 748727012287 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 748727012288 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 748727012289 Helix-hairpin-helix motif; Region: HHH; pfam00633 748727012290 DNA repair protein RadA; Provisional; Region: PRK11823 748727012291 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 748727012292 Walker A motif/ATP binding site; other site 748727012293 ATP binding site [chemical binding]; other site 748727012294 Walker B motif; other site 748727012295 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 748727012296 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 748727012297 Clp amino terminal domain; Region: Clp_N; pfam02861 748727012298 Clp amino terminal domain; Region: Clp_N; pfam02861 748727012299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012300 Walker A motif; other site 748727012301 ATP binding site [chemical binding]; other site 748727012302 Walker B motif; other site 748727012303 arginine finger; other site 748727012304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012305 Walker A motif; other site 748727012306 ATP binding site [chemical binding]; other site 748727012307 Walker B motif; other site 748727012308 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 748727012309 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 748727012310 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 748727012311 ADP binding site [chemical binding]; other site 748727012312 phosphagen binding site; other site 748727012313 substrate specificity loop; other site 748727012314 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 748727012315 UvrB/uvrC motif; Region: UVR; pfam02151 748727012316 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 748727012317 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 748727012318 elongation factor G; Reviewed; Region: PRK12740 748727012319 G1 box; other site 748727012320 putative GEF interaction site [polypeptide binding]; other site 748727012321 GTP/Mg2+ binding site [chemical binding]; other site 748727012322 Switch I region; other site 748727012323 G2 box; other site 748727012324 G3 box; other site 748727012325 Switch II region; other site 748727012326 G4 box; other site 748727012327 G5 box; other site 748727012328 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 748727012329 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 748727012330 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 748727012331 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 748727012332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727012333 glycyl-tRNA synthetase; Provisional; Region: PRK04173 748727012334 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 748727012335 motif 1; other site 748727012336 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 748727012337 active site 748727012338 motif 2; other site 748727012339 motif 3; other site 748727012340 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 748727012341 anticodon binding site; other site 748727012342 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 748727012343 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 748727012344 dimer interface [polypeptide binding]; other site 748727012345 putative anticodon binding site; other site 748727012346 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 748727012347 motif 1; other site 748727012348 active site 748727012349 motif 2; other site 748727012350 motif 3; other site 748727012351 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 748727012352 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748727012353 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748727012354 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 748727012355 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 748727012356 FMN binding site [chemical binding]; other site 748727012357 active site 748727012358 catalytic residues [active] 748727012359 substrate binding site [chemical binding]; other site 748727012360 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748727012361 nucleotide binding site [chemical binding]; other site 748727012362 Type III pantothenate kinase; Region: Pan_kinase; cl17198 748727012363 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 748727012364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012365 Walker A motif; other site 748727012366 ATP binding site [chemical binding]; other site 748727012367 Walker B motif; other site 748727012368 arginine finger; other site 748727012369 Peptidase family M41; Region: Peptidase_M41; pfam01434 748727012370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727012371 active site 748727012372 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 748727012373 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 748727012374 Ligand Binding Site [chemical binding]; other site 748727012375 TilS substrate C-terminal domain; Region: TilS_C; smart00977 748727012376 stage II sporulation protein E; Region: spore_II_E; TIGR02865 748727012377 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 748727012378 hypothetical protein; Provisional; Region: PRK05807 748727012379 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 748727012380 RNA binding site [nucleotide binding]; other site 748727012381 Septum formation initiator; Region: DivIC; pfam04977 748727012382 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 748727012383 YabP family; Region: YabP; cl06766 748727012384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748727012385 RNA binding surface [nucleotide binding]; other site 748727012386 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 748727012387 IHF dimer interface [polypeptide binding]; other site 748727012388 IHF - DNA interface [nucleotide binding]; other site 748727012389 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 748727012390 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 748727012391 putative SAM binding site [chemical binding]; other site 748727012392 putative homodimer interface [polypeptide binding]; other site 748727012393 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 748727012394 homodimer interface [polypeptide binding]; other site 748727012395 metal binding site [ion binding]; metal-binding site 748727012396 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 748727012397 homodimer interface [polypeptide binding]; other site 748727012398 active site 748727012399 putative chemical substrate binding site [chemical binding]; other site 748727012400 metal binding site [ion binding]; metal-binding site 748727012401 stage V sporulation protein B; Region: spore_V_B; TIGR02900 748727012402 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748727012403 stage V sporulation protein T; Region: spore_V_T; TIGR02851 748727012404 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 748727012405 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 748727012406 SurA N-terminal domain; Region: SurA_N_3; cl07813 748727012407 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 748727012408 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 748727012409 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 748727012410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748727012411 ATP binding site [chemical binding]; other site 748727012412 putative Mg++ binding site [ion binding]; other site 748727012413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748727012414 nucleotide binding region [chemical binding]; other site 748727012415 ATP-binding site [chemical binding]; other site 748727012416 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 748727012417 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 748727012418 putative active site [active] 748727012419 catalytic residue [active] 748727012420 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 748727012421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 748727012422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748727012423 protein binding site [polypeptide binding]; other site 748727012424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748727012425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748727012426 dimerization interface [polypeptide binding]; other site 748727012427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748727012428 dimer interface [polypeptide binding]; other site 748727012429 phosphorylation site [posttranslational modification] 748727012430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748727012431 ATP binding site [chemical binding]; other site 748727012432 Mg2+ binding site [ion binding]; other site 748727012433 G-X-G motif; other site 748727012434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748727012435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748727012436 active site 748727012437 phosphorylation site [posttranslational modification] 748727012438 intermolecular recognition site; other site 748727012439 dimerization interface [polypeptide binding]; other site 748727012440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748727012441 DNA binding site [nucleotide binding] 748727012442 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 748727012443 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 748727012444 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727012445 active site 748727012446 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 748727012447 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 748727012448 Substrate binding site; other site 748727012449 Mg++ binding site; other site 748727012450 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 748727012451 active site 748727012452 substrate binding site [chemical binding]; other site 748727012453 CoA binding site [chemical binding]; other site 748727012454 regulatory protein SpoVG; Reviewed; Region: PRK13259 748727012455 pur operon repressor; Provisional; Region: PRK09213 748727012456 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 748727012457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748727012458 active site 748727012459 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 748727012460 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748727012461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748727012462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748727012463 CAAX protease self-immunity; Region: Abi; pfam02517 748727012464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727012465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727012466 non-specific DNA binding site [nucleotide binding]; other site 748727012467 salt bridge; other site 748727012468 sequence-specific DNA binding site [nucleotide binding]; other site 748727012469 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 748727012470 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 748727012471 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 748727012472 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 748727012473 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 748727012474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727012475 Uncharacterized membrane protein [Function unknown]; Region: COG3949 748727012476 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748727012477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748727012478 FeS/SAM binding site; other site 748727012479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748727012480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748727012481 non-specific DNA binding site [nucleotide binding]; other site 748727012482 salt bridge; other site 748727012483 sequence-specific DNA binding site [nucleotide binding]; other site 748727012484 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 748727012485 Catalytic site [active] 748727012486 glutamate racemase; Provisional; Region: PRK00865 748727012487 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 748727012488 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 748727012489 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 748727012490 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 748727012491 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 748727012492 hinge; other site 748727012493 active site 748727012494 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 748727012495 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 748727012496 hypothetical protein; Provisional; Region: PRK05590 748727012497 SEC-C motif; Region: SEC-C; pfam02810 748727012498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748727012499 Interdomain contacts; other site 748727012500 Cytokine receptor motif; other site 748727012501 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 748727012502 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 748727012503 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 748727012504 putative dimer interface [polypeptide binding]; other site 748727012505 putative anticodon binding site; other site 748727012506 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 748727012507 homodimer interface [polypeptide binding]; other site 748727012508 motif 1; other site 748727012509 motif 2; other site 748727012510 active site 748727012511 motif 3; other site 748727012512 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 748727012513 dUTPase; Region: dUTPase_2; pfam08761 748727012514 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 748727012515 active site 748727012516 homodimer interface [polypeptide binding]; other site 748727012517 metal binding site [ion binding]; metal-binding site 748727012518 Protein of unknown function, DUF606; Region: DUF606; pfam04657 748727012519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727012520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727012521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 748727012522 dimerization interface [polypeptide binding]; other site 748727012523 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 748727012524 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 748727012525 active site 748727012526 catalytic residues [active] 748727012527 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 748727012528 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 748727012529 putative ligand binding site [chemical binding]; other site 748727012530 NAD binding site [chemical binding]; other site 748727012531 catalytic site [active] 748727012532 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 748727012533 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 748727012534 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 748727012535 biotin carboxylase; Validated; Region: PRK05586 748727012536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748727012537 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748727012538 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 748727012539 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 748727012540 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 748727012541 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 748727012542 carboxyltransferase (CT) interaction site; other site 748727012543 biotinylation site [posttranslational modification]; other site 748727012544 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 748727012545 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 748727012546 dimer interface [polypeptide binding]; other site 748727012547 active site 748727012548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 748727012549 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 748727012550 NAD(P) binding site [chemical binding]; other site 748727012551 homotetramer interface [polypeptide binding]; other site 748727012552 homodimer interface [polypeptide binding]; other site 748727012553 active site 748727012554 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 748727012555 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 748727012556 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 748727012557 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 748727012558 FMN binding site [chemical binding]; other site 748727012559 substrate binding site [chemical binding]; other site 748727012560 putative catalytic residue [active] 748727012561 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 748727012562 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 748727012563 dimer interface [polypeptide binding]; other site 748727012564 active site 748727012565 CoA binding pocket [chemical binding]; other site 748727012566 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748727012567 MarR family; Region: MarR; pfam01047 748727012568 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 748727012569 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 748727012570 FMN binding site [chemical binding]; other site 748727012571 substrate binding site [chemical binding]; other site 748727012572 putative catalytic residue [active] 748727012573 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 748727012574 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748727012575 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 748727012576 DNA replication protein DnaC; Validated; Region: PRK06835 748727012577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012578 Walker A motif; other site 748727012579 ATP binding site [chemical binding]; other site 748727012580 Walker B motif; other site 748727012581 PEP synthetase regulatory protein; Provisional; Region: PRK05339 748727012582 CoA binding domain; Region: CoA_binding_2; pfam13380 748727012583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748727012584 flavoprotein, HI0933 family; Region: TIGR00275 748727012585 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 748727012586 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 748727012587 active site 748727012588 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 748727012589 active site 748727012590 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 748727012591 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 748727012592 GDP-binding site [chemical binding]; other site 748727012593 ACT binding site; other site 748727012594 IMP binding site; other site 748727012595 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 748727012596 L-aspartate oxidase; Provisional; Region: PRK06175 748727012597 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 748727012598 Aspartase; Region: Aspartase; cd01357 748727012599 active sites [active] 748727012600 tetramer interface [polypeptide binding]; other site 748727012601 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 748727012602 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 748727012603 G1 box; other site 748727012604 GTP/Mg2+ binding site [chemical binding]; other site 748727012605 Switch I region; other site 748727012606 G2 box; other site 748727012607 Switch II region; other site 748727012608 G3 box; other site 748727012609 G4 box; other site 748727012610 G5 box; other site 748727012611 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 748727012612 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 748727012613 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 748727012614 ApbE family; Region: ApbE; pfam02424 748727012615 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 748727012616 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 748727012617 active site 748727012618 metal binding site [ion binding]; metal-binding site 748727012619 Predicted membrane protein [Function unknown]; Region: COG2246 748727012620 GtrA-like protein; Region: GtrA; pfam04138 748727012621 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 748727012622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727012623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748727012624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748727012625 dimerization interface [polypeptide binding]; other site 748727012626 hypothetical protein; Provisional; Region: PRK10621 748727012627 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748727012628 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 748727012629 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 748727012630 Cache domain; Region: Cache_1; pfam02743 748727012631 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748727012632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727012633 dimer interface [polypeptide binding]; other site 748727012634 putative CheW interface [polypeptide binding]; other site 748727012635 agmatine deiminase; Provisional; Region: PRK13551 748727012636 agmatine deiminase; Region: agmatine_aguA; TIGR03380 748727012637 Amino acid permease; Region: AA_permease_2; pfam13520 748727012638 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 748727012639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012640 Walker A motif; other site 748727012641 ATP binding site [chemical binding]; other site 748727012642 Walker B motif; other site 748727012643 arginine finger; other site 748727012644 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727012645 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 748727012646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012647 Walker A motif; other site 748727012648 ATP binding site [chemical binding]; other site 748727012649 Walker B motif; other site 748727012650 arginine finger; other site 748727012651 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748727012652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748727012653 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 748727012654 active site 748727012655 carbamate kinase; Reviewed; Region: PRK12686 748727012656 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748727012657 putative substrate binding site [chemical binding]; other site 748727012658 nucleotide binding site [chemical binding]; other site 748727012659 nucleotide binding site [chemical binding]; other site 748727012660 homodimer interface [polypeptide binding]; other site 748727012661 putrescine carbamoyltransferase; Provisional; Region: PRK02255 748727012662 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748727012663 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748727012664 Domain of unknown function (DUF718); Region: DUF718; cl01281 748727012665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748727012666 putative substrate translocation pore; other site 748727012667 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 748727012668 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 748727012669 intersubunit interface [polypeptide binding]; other site 748727012670 active site 748727012671 Zn2+ binding site [ion binding]; other site 748727012672 L-rhamnose isomerase; Provisional; Region: PRK01076 748727012673 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 748727012674 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 748727012675 N- and C-terminal domain interface [polypeptide binding]; other site 748727012676 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 748727012677 active site 748727012678 putative catalytic site [active] 748727012679 metal binding site [ion binding]; metal-binding site 748727012680 ATP binding site [chemical binding]; other site 748727012681 carbohydrate binding site [chemical binding]; other site 748727012682 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748727012683 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748727012684 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748727012685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748727012686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 748727012687 dimerization interface [polypeptide binding]; other site 748727012688 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748727012689 dimer interface [polypeptide binding]; other site 748727012690 putative CheW interface [polypeptide binding]; other site 748727012691 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 748727012692 Nitrogen regulatory protein P-II; Region: P-II; smart00938 748727012693 potential frameshift: common BLAST hit: gi|153953067|ref|YP_001393832.1| ammonium transporter 748727012694 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 748727012695 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 748727012696 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 748727012697 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 748727012698 putative dimer interface [polypeptide binding]; other site 748727012699 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 748727012700 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 748727012701 putative dimer interface [polypeptide binding]; other site 748727012702 replicative DNA helicase; Provisional; Region: PRK05595 748727012703 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 748727012704 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 748727012705 Walker A motif; other site 748727012706 ATP binding site [chemical binding]; other site 748727012707 Walker B motif; other site 748727012708 DNA binding loops [nucleotide binding] 748727012709 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 748727012710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748727012711 Walker A motif; other site 748727012712 ATP binding site [chemical binding]; other site 748727012713 Walker B motif; other site 748727012714 arginine finger; other site 748727012715 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748727012716 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 748727012717 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 748727012718 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 748727012719 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 748727012720 DHH family; Region: DHH; pfam01368 748727012721 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 748727012722 MazG-like family; Region: MazG-like; pfam12643 748727012723 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 748727012724 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 748727012725 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748727012726 dimer interface [polypeptide binding]; other site 748727012727 ssDNA binding site [nucleotide binding]; other site 748727012728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748727012729 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 748727012730 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 748727012731 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 748727012732 Mechanosensitive ion channel; Region: MS_channel; pfam00924 748727012733 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 748727012734 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 748727012735 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748727012736 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 748727012737 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 748727012738 ParB-like nuclease domain; Region: ParBc; pfam02195 748727012739 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 748727012740 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 748727012741 P-loop; other site 748727012742 Magnesium ion binding site [ion binding]; other site 748727012743 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 748727012744 Magnesium ion binding site [ion binding]; other site 748727012745 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 748727012746 ParB-like nuclease domain; Region: ParBc; pfam02195 748727012747 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 748727012748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748727012749 S-adenosylmethionine binding site [chemical binding]; other site 748727012750 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 748727012751 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 748727012752 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 748727012753 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 748727012754 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 748727012755 trmE is a tRNA modification GTPase; Region: trmE; cd04164 748727012756 G1 box; other site 748727012757 GTP/Mg2+ binding site [chemical binding]; other site 748727012758 Switch I region; other site 748727012759 G2 box; other site 748727012760 Switch II region; other site 748727012761 G3 box; other site 748727012762 G4 box; other site 748727012763 G5 box; other site 748727012764 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 748727012765 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 748727012766 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 748727012767 G-X-X-G motif; other site 748727012768 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 748727012769 RxxxH motif; other site 748727012770 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 748727012771 Haemolytic domain; Region: Haemolytic; pfam01809 748727012772 ribonuclease P; Reviewed; Region: rnpA; PRK00499 748727012773 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399