-- dump date   	20140619_044815
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
86416000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
86416000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
86416000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416000004	Walker A motif; other site
86416000005	ATP binding site [chemical binding]; other site
86416000006	Walker B motif; other site
86416000007	arginine finger; other site
86416000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
86416000009	DnaA box-binding interface [nucleotide binding]; other site
86416000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
86416000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
86416000012	putative DNA binding surface [nucleotide binding]; other site
86416000013	dimer interface [polypeptide binding]; other site
86416000014	beta-clamp/clamp loader binding surface; other site
86416000015	beta-clamp/translesion DNA polymerase binding surface; other site
86416000016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416000017	RNA binding surface [nucleotide binding]; other site
86416000018	recombination protein F; Reviewed; Region: recF; PRK00064
86416000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
86416000020	Walker A/P-loop; other site
86416000021	ATP binding site [chemical binding]; other site
86416000022	Q-loop/lid; other site
86416000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416000024	ABC transporter signature motif; other site
86416000025	Walker B; other site
86416000026	D-loop; other site
86416000027	H-loop/switch region; other site
86416000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
86416000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416000030	Mg2+ binding site [ion binding]; other site
86416000031	G-X-G motif; other site
86416000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
86416000033	anchoring element; other site
86416000034	dimer interface [polypeptide binding]; other site
86416000035	ATP binding site [chemical binding]; other site
86416000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
86416000037	active site
86416000038	putative metal-binding site [ion binding]; other site
86416000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
86416000040	DNA gyrase subunit A; Validated; Region: PRK05560
86416000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
86416000042	CAP-like domain; other site
86416000043	active site
86416000044	primary dimer interface [polypeptide binding]; other site
86416000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416000051	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416000052	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
86416000053	HTH domain; Region: HTH_11; pfam08279
86416000054	3H domain; Region: 3H; pfam02829
86416000055	hypothetical protein; Validated; Region: PRK00068
86416000056	Uncharacterized conserved protein [Function unknown]; Region: COG1615
86416000057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
86416000058	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416000059	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
86416000060	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416000061	catalytic residue [active]
86416000062	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
86416000063	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
86416000064	putative ligand binding site [chemical binding]; other site
86416000065	NAD binding site [chemical binding]; other site
86416000066	dimerization interface [polypeptide binding]; other site
86416000067	catalytic site [active]
86416000068	Uncharacterized conserved protein [Function unknown]; Region: COG4198
86416000069	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
86416000070	seryl-tRNA synthetase; Provisional; Region: PRK05431
86416000071	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
86416000072	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
86416000073	dimer interface [polypeptide binding]; other site
86416000074	active site
86416000075	motif 1; other site
86416000076	motif 2; other site
86416000077	motif 3; other site
86416000078	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416000079	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416000080	FtsX-like permease family; Region: FtsX; pfam02687
86416000081	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416000082	FtsX-like permease family; Region: FtsX; pfam02687
86416000083	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416000084	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416000085	Walker A/P-loop; other site
86416000086	ATP binding site [chemical binding]; other site
86416000087	Q-loop/lid; other site
86416000088	ABC transporter signature motif; other site
86416000089	Walker B; other site
86416000090	D-loop; other site
86416000091	H-loop/switch region; other site
86416000092	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416000093	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416000094	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416000095	active site
86416000096	metal binding site [ion binding]; metal-binding site
86416000097	YibE/F-like protein; Region: YibE_F; pfam07907
86416000098	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
86416000099	active site
86416000100	catalytic site [active]
86416000101	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
86416000102	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416000103	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
86416000104	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
86416000105	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
86416000106	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
86416000107	putative substrate-binding site; other site
86416000108	nickel binding site [ion binding]; other site
86416000109	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
86416000110	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
86416000111	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416000112	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
86416000113	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
86416000114	HupF/HypC family; Region: HupF_HypC; pfam01455
86416000115	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
86416000116	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416000117	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
86416000118	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
86416000119	Multicopper oxidase; Region: Cu-oxidase; pfam00394
86416000120	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
86416000121	Fatty acid desaturase; Region: FA_desaturase; pfam00487
86416000122	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416000123	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
86416000124	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
86416000125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000126	dimer interface [polypeptide binding]; other site
86416000127	conserved gate region; other site
86416000128	putative PBP binding loops; other site
86416000129	ABC-ATPase subunit interface; other site
86416000130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000131	dimer interface [polypeptide binding]; other site
86416000132	conserved gate region; other site
86416000133	putative PBP binding loops; other site
86416000134	ABC-ATPase subunit interface; other site
86416000135	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
86416000136	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
86416000137	Walker A/P-loop; other site
86416000138	ATP binding site [chemical binding]; other site
86416000139	Q-loop/lid; other site
86416000140	ABC transporter signature motif; other site
86416000141	Walker B; other site
86416000142	D-loop; other site
86416000143	H-loop/switch region; other site
86416000144	Predicted membrane protein [Function unknown]; Region: COG4280
86416000145	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
86416000146	catalytic loop [active]
86416000147	iron binding site [ion binding]; other site
86416000148	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
86416000149	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
86416000150	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
86416000151	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
86416000152	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
86416000153	ACS interaction site; other site
86416000154	CODH interaction site; other site
86416000155	cubane metal cluster (B-cluster) [ion binding]; other site
86416000156	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
86416000157	Transcriptional regulator; Region: Rrf2; pfam02082
86416000158	Rrf2 family protein; Region: rrf2_super; TIGR00738
86416000159	phosphatidylserine decarboxylase; Provisional; Region: PRK00723
86416000160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416000161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416000162	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
86416000163	Predicted membrane protein [Function unknown]; Region: COG1511
86416000164	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
86416000165	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
86416000166	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
86416000167	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
86416000168	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
86416000169	Spore germination protein; Region: Spore_permease; cl17796
86416000170	Spore germination protein; Region: Spore_permease; cl17796
86416000171	putative transposase OrfB; Reviewed; Region: PHA02517
86416000172	HTH-like domain; Region: HTH_21; pfam13276
86416000173	Integrase core domain; Region: rve; pfam00665
86416000174	Integrase core domain; Region: rve_3; pfam13683
86416000175	ABC1 family; Region: ABC1; cl17513
86416000176	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
86416000177	Uncharacterized conserved protein [Function unknown]; Region: COG3937
86416000178	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
86416000179	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416000180	Int/Topo IB signature motif; other site
86416000181	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416000182	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416000183	non-specific DNA binding site [nucleotide binding]; other site
86416000184	salt bridge; other site
86416000185	sequence-specific DNA binding site [nucleotide binding]; other site
86416000186	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416000187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416000188	non-specific DNA binding site [nucleotide binding]; other site
86416000189	salt bridge; other site
86416000190	sequence-specific DNA binding site [nucleotide binding]; other site
86416000191	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
86416000192	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
86416000193	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
86416000194	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
86416000195	active site
86416000196	metal binding site [ion binding]; metal-binding site
86416000197	interdomain interaction site; other site
86416000198	D5 N terminal like; Region: D5_N; smart00885
86416000199	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
86416000200	Helix-turn-helix domain; Region: HTH_28; pfam13518
86416000201	Transposase; Region: HTH_Tnp_IS630; pfam01710
86416000202	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
86416000203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416000204	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416000205	DNA binding residues [nucleotide binding]
86416000206	Probable transposase; Region: OrfB_IS605; pfam01385
86416000207	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
86416000208	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
86416000209	Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600
86416000210	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
86416000211	nucleoside/Zn binding site; other site
86416000212	dimer interface [polypeptide binding]; other site
86416000213	catalytic motif [active]
86416000214	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416000215	Zn2+ binding site [ion binding]; other site
86416000216	Mg2+ binding site [ion binding]; other site
86416000217	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
86416000218	Coat F domain; Region: Coat_F; pfam07875
86416000219	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
86416000220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416000221	Walker A motif; other site
86416000222	ATP binding site [chemical binding]; other site
86416000223	Walker B motif; other site
86416000224	arginine finger; other site
86416000225	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
86416000226	hypothetical protein; Validated; Region: PRK00153
86416000227	recombination protein RecR; Reviewed; Region: recR; PRK00076
86416000228	RecR protein; Region: RecR; pfam02132
86416000229	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
86416000230	putative active site [active]
86416000231	putative metal-binding site [ion binding]; other site
86416000232	tetramer interface [polypeptide binding]; other site
86416000233	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
86416000234	SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441
86416000235	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
86416000236	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
86416000237	putative NADH binding site [chemical binding]; other site
86416000238	putative active site [active]
86416000239	nudix motif; other site
86416000240	putative metal binding site [ion binding]; other site
86416000241	FlxA-like protein; Region: FlxA; pfam14282
86416000242	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416000243	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
86416000244	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416000245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416000246	Walker A/P-loop; other site
86416000247	ATP binding site [chemical binding]; other site
86416000248	Q-loop/lid; other site
86416000249	ABC transporter signature motif; other site
86416000250	Walker B; other site
86416000251	D-loop; other site
86416000252	H-loop/switch region; other site
86416000253	Class I aldolases; Region: Aldolase_Class_I; cl17187
86416000254	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
86416000255	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
86416000256	active site
86416000257	Zn binding site [ion binding]; other site
86416000258	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
86416000259	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416000260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416000261	S-adenosylmethionine binding site [chemical binding]; other site
86416000262	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
86416000263	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
86416000264	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
86416000265	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
86416000266	active site
86416000267	Fe-S cluster binding site [ion binding]; other site
86416000268	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
86416000269	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
86416000270	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416000271	catalytic residue [active]
86416000272	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
86416000273	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
86416000274	catalytic triad [active]
86416000275	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
86416000276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416000277	motif II; other site
86416000278	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
86416000279	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
86416000280	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
86416000281	putative active site [active]
86416000282	putative CoA binding site [chemical binding]; other site
86416000283	nudix motif; other site
86416000284	metal binding site [ion binding]; metal-binding site
86416000285	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
86416000286	EamA-like transporter family; Region: EamA; pfam00892
86416000287	EamA-like transporter family; Region: EamA; pfam00892
86416000288	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
86416000289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000290	dimer interface [polypeptide binding]; other site
86416000291	conserved gate region; other site
86416000292	putative PBP binding loops; other site
86416000293	ABC-ATPase subunit interface; other site
86416000294	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
86416000295	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
86416000296	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
86416000297	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
86416000298	Walker A/P-loop; other site
86416000299	ATP binding site [chemical binding]; other site
86416000300	Q-loop/lid; other site
86416000301	ABC transporter signature motif; other site
86416000302	Walker B; other site
86416000303	D-loop; other site
86416000304	H-loop/switch region; other site
86416000305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000306	dimer interface [polypeptide binding]; other site
86416000307	conserved gate region; other site
86416000308	putative PBP binding loops; other site
86416000309	ABC-ATPase subunit interface; other site
86416000310	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416000311	4Fe-4S binding domain; Region: Fer4; pfam00037
86416000312	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
86416000313	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416000314	homodimer interface [polypeptide binding]; other site
86416000315	substrate-cofactor binding pocket; other site
86416000316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416000317	catalytic residue [active]
86416000318	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
86416000319	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
86416000320	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
86416000321	Pyruvate formate lyase 1; Region: PFL1; cd01678
86416000322	coenzyme A binding site [chemical binding]; other site
86416000323	active site
86416000324	catalytic residues [active]
86416000325	glycine loop; other site
86416000326	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
86416000327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416000328	FeS/SAM binding site; other site
86416000329	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
86416000330	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416000331	Zn2+ binding site [ion binding]; other site
86416000332	Mg2+ binding site [ion binding]; other site
86416000333	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
86416000334	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
86416000335	Catalytic site [active]
86416000336	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
86416000337	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
86416000338	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416000339	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
86416000340	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
86416000341	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
86416000342	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
86416000343	active site
86416000344	NTP binding site [chemical binding]; other site
86416000345	metal binding triad [ion binding]; metal-binding site
86416000346	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
86416000347	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416000348	Zn2+ binding site [ion binding]; other site
86416000349	Mg2+ binding site [ion binding]; other site
86416000350	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
86416000351	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
86416000352	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
86416000353	aspartate kinase; Reviewed; Region: PRK09034
86416000354	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
86416000355	nucleotide binding site [chemical binding]; other site
86416000356	substrate binding site [chemical binding]; other site
86416000357	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
86416000358	allosteric regulatory residue; other site
86416000359	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
86416000360	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
86416000361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416000362	Walker A/P-loop; other site
86416000363	ATP binding site [chemical binding]; other site
86416000364	Q-loop/lid; other site
86416000365	ABC transporter signature motif; other site
86416000366	Walker B; other site
86416000367	D-loop; other site
86416000368	H-loop/switch region; other site
86416000369	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
86416000370	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416000371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416000372	non-specific DNA binding site [nucleotide binding]; other site
86416000373	salt bridge; other site
86416000374	sequence-specific DNA binding site [nucleotide binding]; other site
86416000375	NAD-dependent deacetylase; Provisional; Region: PRK00481
86416000376	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
86416000377	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
86416000378	dimer interface [polypeptide binding]; other site
86416000379	catalytic triad [active]
86416000380	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
86416000381	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
86416000382	metal binding site [ion binding]; metal-binding site
86416000383	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416000384	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
86416000385	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
86416000386	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
86416000387	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
86416000388	homodimer interface [polypeptide binding]; other site
86416000389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416000390	catalytic residue [active]
86416000391	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
86416000392	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
86416000393	catalytic site [active]
86416000394	G-X2-G-X-G-K; other site
86416000395	Protein of unknown function (DUF970); Region: DUF970; pfam06153
86416000396	DNA polymerase III subunit delta'; Validated; Region: PRK05564
86416000397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416000398	Walker A motif; other site
86416000399	ATP binding site [chemical binding]; other site
86416000400	Walker B motif; other site
86416000401	arginine finger; other site
86416000402	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
86416000403	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
86416000404	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
86416000405	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416000406	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
86416000407	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416000408	HPr interaction site; other site
86416000409	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416000410	active site
86416000411	phosphorylation site [posttranslational modification]
86416000412	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
86416000413	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
86416000414	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
86416000415	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
86416000416	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
86416000417	ligand binding site [chemical binding]; other site
86416000418	LrgB-like family; Region: LrgB; pfam04172
86416000419	LrgA family; Region: LrgA; pfam03788
86416000420	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
86416000421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
86416000422	Predicted methyltransferases [General function prediction only]; Region: COG0313
86416000423	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
86416000424	putative SAM binding site [chemical binding]; other site
86416000425	putative homodimer interface [polypeptide binding]; other site
86416000426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
86416000427	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416000428	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416000429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
86416000430	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416000431	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416000432	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
86416000433	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
86416000434	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
86416000435	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
86416000436	metal binding triad [ion binding]; metal-binding site
86416000437	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
86416000438	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
86416000439	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416000440	catalytic residue [active]
86416000441	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
86416000442	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
86416000443	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
86416000444	Ligand Binding Site [chemical binding]; other site
86416000445	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
86416000446	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
86416000447	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
86416000448	dimer interface [polypeptide binding]; other site
86416000449	substrate binding site [chemical binding]; other site
86416000450	ATP binding site [chemical binding]; other site
86416000451	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
86416000452	Na binding site [ion binding]; other site
86416000453	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
86416000454	substrate binding site [chemical binding]; other site
86416000455	multimerization interface [polypeptide binding]; other site
86416000456	ATP binding site [chemical binding]; other site
86416000457	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
86416000458	thiamine phosphate binding site [chemical binding]; other site
86416000459	active site
86416000460	pyrophosphate binding site [ion binding]; other site
86416000461	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
86416000462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416000463	Coenzyme A binding pocket [chemical binding]; other site
86416000464	ornithine carbamoyltransferase; Validated; Region: PRK02102
86416000465	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
86416000466	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
86416000467	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
86416000468	homopentamer interface [polypeptide binding]; other site
86416000469	active site
86416000470	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
86416000471	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
86416000472	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
86416000473	dimerization interface [polypeptide binding]; other site
86416000474	active site
86416000475	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
86416000476	Lumazine binding domain; Region: Lum_binding; pfam00677
86416000477	Lumazine binding domain; Region: Lum_binding; pfam00677
86416000478	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
86416000479	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
86416000480	catalytic motif [active]
86416000481	Zn binding site [ion binding]; other site
86416000482	RibD C-terminal domain; Region: RibD_C; cl17279
86416000483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416000484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416000485	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
86416000486	HlyD family secretion protein; Region: HlyD_3; pfam13437
86416000487	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
86416000488	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416000489	Walker A/P-loop; other site
86416000490	ATP binding site [chemical binding]; other site
86416000491	Q-loop/lid; other site
86416000492	ABC transporter signature motif; other site
86416000493	Walker B; other site
86416000494	D-loop; other site
86416000495	H-loop/switch region; other site
86416000496	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
86416000497	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416000498	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
86416000499	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
86416000500	homotrimer interaction site [polypeptide binding]; other site
86416000501	zinc binding site [ion binding]; other site
86416000502	CDP-binding sites; other site
86416000503	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166
86416000504	active site
86416000505	catalytic site [active]
86416000506	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416000507	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
86416000508	putative active site [active]
86416000509	putative metal binding site [ion binding]; other site
86416000510	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
86416000511	Uncharacterized conserved protein [Function unknown]; Region: COG1434
86416000512	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
86416000513	putative active site [active]
86416000514	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416000515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
86416000516	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416000517	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
86416000518	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
86416000519	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
86416000520	Fe-S cluster binding site [ion binding]; other site
86416000521	active site
86416000522	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
86416000523	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
86416000524	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416000525	ATP binding site [chemical binding]; other site
86416000526	putative Mg++ binding site [ion binding]; other site
86416000527	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416000528	nucleotide binding region [chemical binding]; other site
86416000529	ATP-binding site [chemical binding]; other site
86416000530	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
86416000531	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
86416000532	active site
86416000533	HIGH motif; other site
86416000534	KMSKS motif; other site
86416000535	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
86416000536	tRNA binding surface [nucleotide binding]; other site
86416000537	anticodon binding site; other site
86416000538	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
86416000539	dimer interface [polypeptide binding]; other site
86416000540	putative tRNA-binding site [nucleotide binding]; other site
86416000541	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416000542	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416000543	WHG domain; Region: WHG; pfam13305
86416000544	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416000545	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416000546	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416000547	ykoK leader; Clopa_0248; IMG reference gene:2509567165
86416000548	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
86416000549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000550	dimer interface [polypeptide binding]; other site
86416000551	conserved gate region; other site
86416000552	putative PBP binding loops; other site
86416000553	ABC-ATPase subunit interface; other site
86416000554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416000555	dimer interface [polypeptide binding]; other site
86416000556	conserved gate region; other site
86416000557	putative PBP binding loops; other site
86416000558	ABC-ATPase subunit interface; other site
86416000559	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416000560	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416000561	Walker A/P-loop; other site
86416000562	ATP binding site [chemical binding]; other site
86416000563	Q-loop/lid; other site
86416000564	ABC transporter signature motif; other site
86416000565	Walker B; other site
86416000566	D-loop; other site
86416000567	H-loop/switch region; other site
86416000568	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
86416000569	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
86416000570	DNA-binding site [nucleotide binding]; DNA binding site
86416000571	RNA-binding motif; other site
86416000572	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
86416000573	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416000574	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
86416000575	active site
86416000576	Domain of unknown function (DUF348); Region: DUF348; pfam03990
86416000577	G5 domain; Region: G5; pfam07501
86416000578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
86416000579	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
86416000580	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
86416000581	putative active site [active]
86416000582	putative metal binding site [ion binding]; other site
86416000583	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
86416000584	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
86416000585	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416000586	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
86416000587	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
86416000588	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
86416000589	active site
86416000590	Substrate binding site; other site
86416000591	Mg++ binding site; other site
86416000592	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416000593	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
86416000594	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
86416000595	active site
86416000596	substrate binding site [chemical binding]; other site
86416000597	metal binding site [ion binding]; metal-binding site
86416000598	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
86416000599	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
86416000600	Dimer interface [polypeptide binding]; other site
86416000601	anticodon binding site; other site
86416000602	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
86416000603	homodimer interface [polypeptide binding]; other site
86416000604	motif 1; other site
86416000605	motif 2; other site
86416000606	active site
86416000607	motif 3; other site
86416000608	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
86416000609	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
86416000610	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
86416000611	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
86416000612	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
86416000613	GatB domain; Region: GatB_Yqey; smart00845
86416000614	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
86416000615	ATP cone domain; Region: ATP-cone; pfam03477
86416000616	Class III ribonucleotide reductase; Region: RNR_III; cd01675
86416000617	effector binding site; other site
86416000618	active site
86416000619	Zn binding site [ion binding]; other site
86416000620	glycine loop; other site
86416000621	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
86416000622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416000623	FeS/SAM binding site; other site
86416000624	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
86416000625	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
86416000626	CAAX protease self-immunity; Region: Abi; pfam02517
86416000627	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
86416000628	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
86416000629	HIGH motif; other site
86416000630	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
86416000631	active site
86416000632	KMSKS motif; other site
86416000633	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
86416000634	tRNA binding surface [nucleotide binding]; other site
86416000635	anticodon binding site; other site
86416000636	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416000637	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416000638	DNA binding site [nucleotide binding]
86416000639	domain linker motif; other site
86416000640	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416000641	dimerization interface [polypeptide binding]; other site
86416000642	ligand binding site [chemical binding]; other site
86416000643	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
86416000644	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
86416000645	CAAX protease self-immunity; Region: Abi; pfam02517
86416000646	Part of AAA domain; Region: AAA_19; pfam13245
86416000647	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
86416000648	AAA domain; Region: AAA_12; pfam13087
86416000649	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
86416000650	peptidase T; Region: peptidase-T; TIGR01882
86416000651	metal binding site [ion binding]; metal-binding site
86416000652	dimer interface [polypeptide binding]; other site
86416000653	Predicted permeases [General function prediction only]; Region: COG0730
86416000654	DNA topoisomerase III; Provisional; Region: PRK07726
86416000655	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
86416000656	active site
86416000657	putative interdomain interaction site [polypeptide binding]; other site
86416000658	putative metal-binding site [ion binding]; other site
86416000659	putative nucleotide binding site [chemical binding]; other site
86416000660	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
86416000661	domain I; other site
86416000662	DNA binding groove [nucleotide binding]
86416000663	phosphate binding site [ion binding]; other site
86416000664	domain II; other site
86416000665	domain III; other site
86416000666	nucleotide binding site [chemical binding]; other site
86416000667	catalytic site [active]
86416000668	domain IV; other site
86416000669	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416000670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416000671	active site
86416000672	phosphorylation site [posttranslational modification]
86416000673	intermolecular recognition site; other site
86416000674	dimerization interface [polypeptide binding]; other site
86416000675	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416000676	DNA binding site [nucleotide binding]
86416000677	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416000678	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416000679	dimerization interface [polypeptide binding]; other site
86416000680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416000681	dimer interface [polypeptide binding]; other site
86416000682	phosphorylation site [posttranslational modification]
86416000683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416000684	ATP binding site [chemical binding]; other site
86416000685	Mg2+ binding site [ion binding]; other site
86416000686	G-X-G motif; other site
86416000687	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
86416000688	homodecamer interface [polypeptide binding]; other site
86416000689	GTP cyclohydrolase I; Provisional; Region: PLN03044
86416000690	active site
86416000691	putative catalytic site residues [active]
86416000692	zinc binding site [ion binding]; other site
86416000693	GTP-CH-I/GFRP interaction surface; other site
86416000694	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416000695	Zn2+ binding site [ion binding]; other site
86416000696	Mg2+ binding site [ion binding]; other site
86416000697	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
86416000698	dihydropteroate synthase; Region: DHPS; TIGR01496
86416000699	substrate binding pocket [chemical binding]; other site
86416000700	dimer interface [polypeptide binding]; other site
86416000701	inhibitor binding site; inhibition site
86416000702	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
86416000703	homooctamer interface [polypeptide binding]; other site
86416000704	active site
86416000705	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
86416000706	catalytic center binding site [active]
86416000707	ATP binding site [chemical binding]; other site
86416000708	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
86416000709	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
86416000710	active site
86416000711	metal binding site [ion binding]; metal-binding site
86416000712	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416000713	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416000714	active site
86416000715	metal binding site [ion binding]; metal-binding site
86416000716	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
86416000717	HlyD family secretion protein; Region: HlyD_3; pfam13437
86416000718	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416000719	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416000720	Walker A/P-loop; other site
86416000721	ATP binding site [chemical binding]; other site
86416000722	Q-loop/lid; other site
86416000723	ABC transporter signature motif; other site
86416000724	Walker B; other site
86416000725	D-loop; other site
86416000726	H-loop/switch region; other site
86416000727	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416000728	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416000729	FtsX-like permease family; Region: FtsX; pfam02687
86416000730	Quinolinate synthetase A protein; Region: NadA; pfam02445
86416000731	L-aspartate oxidase; Provisional; Region: PRK06175
86416000732	FAD binding domain; Region: FAD_binding_2; pfam00890
86416000733	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
86416000734	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
86416000735	dimerization interface [polypeptide binding]; other site
86416000736	active site
86416000737	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
86416000738	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416000739	FeS/SAM binding site; other site
86416000740	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
86416000741	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416000742	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416000743	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
86416000744	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416000745	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416000746	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
86416000747	active site
86416000748	ATP binding site [chemical binding]; other site
86416000749	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
86416000750	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416000751	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416000752	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
86416000753	substrate binding site [chemical binding]; other site
86416000754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416000755	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
86416000756	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
86416000757	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416000758	active site
86416000759	ATP binding site [chemical binding]; other site
86416000760	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
86416000761	substrate binding site [chemical binding]; other site
86416000762	YabG peptidase U57; Region: Peptidase_U57; cl05250
86416000763	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416000764	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416000765	catalytic residues [active]
86416000766	catalytic nucleophile [active]
86416000767	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416000768	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416000769	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416000770	Synaptic Site I dimer interface [polypeptide binding]; other site
86416000771	DNA binding site [nucleotide binding]
86416000772	Recombinase; Region: Recombinase; pfam07508
86416000773	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
86416000774	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
86416000775	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416000776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416000777	non-specific DNA binding site [nucleotide binding]; other site
86416000778	salt bridge; other site
86416000779	sequence-specific DNA binding site [nucleotide binding]; other site
86416000780	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416000781	non-specific DNA binding site [nucleotide binding]; other site
86416000782	salt bridge; other site
86416000783	sequence-specific DNA binding site [nucleotide binding]; other site
86416000784	Helix-turn-helix domain; Region: HTH_31; pfam13560
86416000785	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416000786	aspartate racemase; Region: asp_race; TIGR00035
86416000787	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416000788	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416000789	dimer interface [polypeptide binding]; other site
86416000790	ssDNA binding site [nucleotide binding]; other site
86416000791	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416000792	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416000793	active site
86416000794	DNA binding site [nucleotide binding]
86416000795	Int/Topo IB signature motif; other site
86416000796	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
86416000797	HNH endonuclease; Region: HNH; pfam01844
86416000798	active site
86416000799	Phage terminase, small subunit; Region: Terminase_4; cl01525
86416000800	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
86416000801	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
86416000802	Phage-related protein [Function unknown]; Region: COG4695; cl01923
86416000803	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
86416000804	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
86416000805	oligomer interface [polypeptide binding]; other site
86416000806	active site residues [active]
86416000807	Phage capsid family; Region: Phage_capsid; pfam05065
86416000808	Phage-related minor tail protein [Function unknown]; Region: COG5280
86416000809	Phage tail protein; Region: Sipho_tail; cl17486
86416000810	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
86416000811	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
86416000812	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
86416000813	active site
86416000814	catalytic residues [active]
86416000815	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416000816	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
86416000817	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
86416000818	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416000819	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416000820	active site
86416000821	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416000822	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416000823	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416000824	Family description; Region: VCBS; pfam13517
86416000825	Family description; Region: VCBS; pfam13517
86416000826	Family description; Region: VCBS; pfam13517
86416000827	Family description; Region: VCBS; pfam13517
86416000828	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
86416000829	catalytic residue [active]
86416000830	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
86416000831	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
86416000832	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
86416000833	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
86416000834	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416000835	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
86416000836	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
86416000837	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
86416000838	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
86416000839	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
86416000840	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
86416000841	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
86416000842	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416000843	germination protein YpeB; Region: spore_YpeB; TIGR02889
86416000844	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
86416000845	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
86416000846	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
86416000847	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
86416000848	CTP synthetase; Validated; Region: pyrG; PRK05380
86416000849	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
86416000850	Catalytic site [active]
86416000851	active site
86416000852	UTP binding site [chemical binding]; other site
86416000853	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
86416000854	active site
86416000855	putative oxyanion hole; other site
86416000856	catalytic triad [active]
86416000857	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
86416000858	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
86416000859	transcription termination factor Rho; Provisional; Region: PRK12608
86416000860	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
86416000861	RNA binding site [nucleotide binding]; other site
86416000862	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
86416000863	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
86416000864	multimer interface [polypeptide binding]; other site
86416000865	Walker A motif; other site
86416000866	Walker A motif; other site
86416000867	ATP binding site [chemical binding]; other site
86416000868	Walker B motif; other site
86416000869	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
86416000870	thymidine kinase; Provisional; Region: PRK04296
86416000871	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
86416000872	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
86416000873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416000874	S-adenosylmethionine binding site [chemical binding]; other site
86416000875	peptide chain release factor 1; Validated; Region: prfA; PRK00591
86416000876	This domain is found in peptide chain release factors; Region: PCRF; smart00937
86416000877	RF-1 domain; Region: RF-1; pfam00472
86416000878	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
86416000879	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
86416000880	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
86416000881	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
86416000882	Low molecular weight phosphatase family; Region: LMWPc; cd00115
86416000883	active site
86416000884	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
86416000885	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416000886	active site
86416000887	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
86416000888	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
86416000889	Hemerythrin; Region: Hemerythrin; cd12107
86416000890	Fe binding site [ion binding]; other site
86416000891	GAF domain; Region: GAF; cl17456
86416000892	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
86416000893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416000894	Walker A motif; other site
86416000895	ATP binding site [chemical binding]; other site
86416000896	Walker B motif; other site
86416000897	arginine finger; other site
86416000898	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
86416000899	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
86416000900	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
86416000901	putative ligand binding site [chemical binding]; other site
86416000902	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
86416000903	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
86416000904	Walker A/P-loop; other site
86416000905	ATP binding site [chemical binding]; other site
86416000906	Q-loop/lid; other site
86416000907	ABC transporter signature motif; other site
86416000908	Walker B; other site
86416000909	D-loop; other site
86416000910	H-loop/switch region; other site
86416000911	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
86416000912	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
86416000913	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
86416000914	TM-ABC transporter signature motif; other site
86416000915	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
86416000916	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
86416000917	TM-ABC transporter signature motif; other site
86416000918	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
86416000919	XdhC Rossmann domain; Region: XdhC_C; pfam13478
86416000920	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
86416000921	putative MPT binding site; other site
86416000922	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
86416000923	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
86416000924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416000925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416000926	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416000927	dimerization interface [polypeptide binding]; other site
86416000928	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416000929	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416000930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416000931	Walker A/P-loop; other site
86416000932	ATP binding site [chemical binding]; other site
86416000933	Q-loop/lid; other site
86416000934	ABC transporter signature motif; other site
86416000935	Walker B; other site
86416000936	D-loop; other site
86416000937	H-loop/switch region; other site
86416000938	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416000939	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416000940	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
86416000941	Walker A/P-loop; other site
86416000942	ATP binding site [chemical binding]; other site
86416000943	Q-loop/lid; other site
86416000944	ABC transporter signature motif; other site
86416000945	Walker B; other site
86416000946	D-loop; other site
86416000947	H-loop/switch region; other site
86416000948	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
86416000949	putative active site [active]
86416000950	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
86416000951	trimer interface [polypeptide binding]; other site
86416000952	dimer interface [polypeptide binding]; other site
86416000953	putative active site [active]
86416000954	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
86416000955	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
86416000956	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416000957	catalytic residue [active]
86416000958	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
86416000959	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
86416000960	catalytic loop [active]
86416000961	iron binding site [ion binding]; other site
86416000962	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
86416000963	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
86416000964	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
86416000965	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
86416000966	homotrimer interaction site [polypeptide binding]; other site
86416000967	putative active site [active]
86416000968	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
86416000969	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
86416000970	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416000971	catalytic residue [active]
86416000972	diaminopimelate epimerase; Provisional; Region: PRK13577
86416000973	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
86416000974	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
86416000975	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
86416000976	selenophosphate synthetase; Provisional; Region: PRK00943
86416000977	dimerization interface [polypeptide binding]; other site
86416000978	putative ATP binding site [chemical binding]; other site
86416000979	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
86416000980	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
86416000981	CPxP  motif; other site
86416000982	DsrE/DsrF-like family; Region: DrsE; pfam02635
86416000983	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
86416000984	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
86416000985	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
86416000986	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
86416000987	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
86416000988	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
86416000989	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
86416000990	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
86416000991	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
86416000992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416000993	motif II; other site
86416000994	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
86416000995	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
86416000996	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416000997	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
86416000998	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
86416000999	active site
86416001000	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
86416001001	diiron binding motif [ion binding]; other site
86416001002	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
86416001003	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416001004	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416001005	putative active site [active]
86416001006	putative NTP binding site [chemical binding]; other site
86416001007	putative nucleic acid binding site [nucleotide binding]; other site
86416001008	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416001009	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
86416001010	Ligand binding site; other site
86416001011	metal-binding site
86416001012	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
86416001013	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
86416001014	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
86416001015	active site
86416001016	putative substrate binding pocket [chemical binding]; other site
86416001017	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416001018	peptidase; Reviewed; Region: PRK13004
86416001019	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
86416001020	putative metal binding site [ion binding]; other site
86416001021	putative dimer interface [polypeptide binding]; other site
86416001022	phenylhydantoinase; Validated; Region: PRK08323
86416001023	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
86416001024	tetramer interface [polypeptide binding]; other site
86416001025	active site
86416001026	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
86416001027	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
86416001028	active site
86416001029	putative substrate binding pocket [chemical binding]; other site
86416001030	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
86416001031	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416001032	phosphate binding site [ion binding]; other site
86416001033	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416001034	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
86416001035	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
86416001036	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
86416001037	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
86416001038	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
86416001039	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
86416001040	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
86416001041	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
86416001042	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
86416001043	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
86416001044	Ligand binding site; other site
86416001045	Putative Catalytic site; other site
86416001046	DXD motif; other site
86416001047	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416001048	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416001049	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
86416001050	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
86416001051	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
86416001052	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
86416001053	serine O-acetyltransferase; Region: cysE; TIGR01172
86416001054	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
86416001055	trimer interface [polypeptide binding]; other site
86416001056	active site
86416001057	substrate binding site [chemical binding]; other site
86416001058	CoA binding site [chemical binding]; other site
86416001059	Predicted ATPase [General function prediction only]; Region: COG3910
86416001060	ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227
86416001061	Walker A/P-loop; other site
86416001062	ATP binding site [chemical binding]; other site
86416001063	Q-loop/lid; other site
86416001064	ABC transporter signature motif; other site
86416001065	Walker B; other site
86416001066	D-loop; other site
86416001067	H-loop/switch region; other site
86416001068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416001069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416001070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
86416001071	dimerization interface [polypeptide binding]; other site
86416001072	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
86416001073	substrate binding site [chemical binding]; other site
86416001074	zinc-binding site [ion binding]; other site
86416001075	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001076	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001077	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
86416001078	Predicted transcriptional regulator [Transcription]; Region: COG2378
86416001079	HTH domain; Region: HTH_11; pfam08279
86416001080	WYL domain; Region: WYL; pfam13280
86416001081	SnoaL-like domain; Region: SnoaL_2; pfam12680
86416001082	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
86416001083	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
86416001084	FAD binding site [chemical binding]; other site
86416001085	Hemerythrin-like domain; Region: Hr-like; cd12108
86416001086	Fe binding site [ion binding]; other site
86416001087	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
86416001088	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416001089	substrate binding pocket [chemical binding]; other site
86416001090	membrane-bound complex binding site; other site
86416001091	hinge residues; other site
86416001092	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
86416001093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001094	dimer interface [polypeptide binding]; other site
86416001095	conserved gate region; other site
86416001096	putative PBP binding loops; other site
86416001097	ABC-ATPase subunit interface; other site
86416001098	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
86416001099	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
86416001100	Walker A/P-loop; other site
86416001101	ATP binding site [chemical binding]; other site
86416001102	Q-loop/lid; other site
86416001103	ABC transporter signature motif; other site
86416001104	Walker B; other site
86416001105	D-loop; other site
86416001106	H-loop/switch region; other site
86416001107	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416001108	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416001109	Transcriptional regulator PadR-like family; Region: PadR; cl17335
86416001110	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416001111	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416001112	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416001113	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416001114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416001115	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
86416001116	dimer interface [polypeptide binding]; other site
86416001117	FMN binding site [chemical binding]; other site
86416001118	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416001119	Coenzyme A binding pocket [chemical binding]; other site
86416001120	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
86416001121	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416001122	active site
86416001123	metal binding site [ion binding]; metal-binding site
86416001124	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416001125	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
86416001126	phosphate binding site [ion binding]; other site
86416001127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
86416001128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416001129	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001130	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001131	MMPL family; Region: MMPL; pfam03176
86416001132	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
86416001133	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416001134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416001135	S-adenosylmethionine binding site [chemical binding]; other site
86416001136	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
86416001137	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416001138	Coenzyme A binding pocket [chemical binding]; other site
86416001139	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
86416001140	catalytic core [active]
86416001141	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
86416001142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416001143	S-adenosylmethionine binding site [chemical binding]; other site
86416001144	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
86416001145	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
86416001146	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
86416001147	Flavodoxin domain; Region: Flavodoxin_5; cl17428
86416001148	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
86416001149	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001151	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416001152	DNA-binding site [nucleotide binding]; DNA binding site
86416001153	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
86416001154	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
86416001155	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416001156	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416001157	Ca binding site [ion binding]; other site
86416001158	active site
86416001159	catalytic site [active]
86416001160	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
86416001161	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416001162	active site turn [active]
86416001163	phosphorylation site [posttranslational modification]
86416001164	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416001165	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
86416001166	HPr interaction site; other site
86416001167	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416001168	active site
86416001169	phosphorylation site [posttranslational modification]
86416001170	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
86416001171	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
86416001172	DsrE/DsrF-like family; Region: DrsE; cl00672
86416001173	Transcriptional regulators [Transcription]; Region: FadR; COG2186
86416001174	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416001175	DNA-binding site [nucleotide binding]; DNA binding site
86416001176	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
86416001177	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
86416001178	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
86416001179	Uncharacterized conserved protein [Function unknown]; Region: COG1683
86416001180	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
86416001181	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
86416001182	conserved cys residue [active]
86416001183	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
86416001184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416001185	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416001186	ABC transporter; Region: ABC_tran_2; pfam12848
86416001187	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416001188	H+ Antiporter protein; Region: 2A0121; TIGR00900
86416001189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001190	putative substrate translocation pore; other site
86416001191	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
86416001192	stage II sporulation protein P; Region: spore_II_P; TIGR02867
86416001193	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
86416001194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416001196	putative substrate translocation pore; other site
86416001197	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
86416001198	putative deacylase active site [active]
86416001199	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
86416001200	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
86416001201	molybdopterin cofactor binding site; other site
86416001202	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
86416001203	putative molybdopterin cofactor binding site; other site
86416001204	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
86416001205	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
86416001206	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
86416001207	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
86416001208	Dimer interface [polypeptide binding]; other site
86416001209	anticodon binding site; other site
86416001210	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
86416001211	homodimer interface [polypeptide binding]; other site
86416001212	motif 1; other site
86416001213	motif 2; other site
86416001214	active site
86416001215	motif 3; other site
86416001216	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
86416001217	Zn binding site [ion binding]; other site
86416001218	toxin interface [polypeptide binding]; other site
86416001219	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
86416001220	4Fe-4S binding domain; Region: Fer4; cl02805
86416001221	This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078
86416001222	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
86416001223	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
86416001224	dimer interface [polypeptide binding]; other site
86416001225	PYR/PP interface [polypeptide binding]; other site
86416001226	TPP binding site [chemical binding]; other site
86416001227	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
86416001228	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
86416001229	TPP-binding site [chemical binding]; other site
86416001230	dimer interface [polypeptide binding]; other site
86416001231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001233	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
86416001234	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416001235	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
86416001236	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
86416001237	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416001238	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416001239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416001240	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
86416001241	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
86416001242	Small acid-soluble spore protein H family; Region: SspH; cl06949
86416001243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
86416001244	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
86416001245	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
86416001246	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416001247	Transcriptional regulator PadR-like family; Region: PadR; cl17335
86416001248	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416001249	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416001250	dimer interface [polypeptide binding]; other site
86416001251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416001252	catalytic residue [active]
86416001253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416001254	S-adenosylmethionine binding site [chemical binding]; other site
86416001255	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
86416001256	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
86416001257	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
86416001258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416001259	FeS/SAM binding site; other site
86416001260	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416001261	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
86416001262	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416001263	FeS/SAM binding site; other site
86416001264	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416001265	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
86416001266	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
86416001267	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
86416001268	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
86416001269	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
86416001270	DNA binding site [nucleotide binding]
86416001271	active site
86416001272	endonuclease IV; Provisional; Region: PRK01060
86416001273	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
86416001274	AP (apurinic/apyrimidinic) site pocket; other site
86416001275	DNA interaction; other site
86416001276	Metal-binding active site; metal-binding site
86416001277	A new structural DNA glycosylase; Region: AlkD_like; cd06561
86416001278	active site
86416001279	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
86416001280	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
86416001281	Walker A/P-loop; other site
86416001282	ATP binding site [chemical binding]; other site
86416001283	Q-loop/lid; other site
86416001284	ABC transporter signature motif; other site
86416001285	Walker B; other site
86416001286	D-loop; other site
86416001287	H-loop/switch region; other site
86416001288	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
86416001289	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
86416001290	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
86416001291	TM-ABC transporter signature motif; other site
86416001292	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
86416001293	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
86416001294	TM-ABC transporter signature motif; other site
86416001295	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
86416001296	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416001297	Int/Topo IB signature motif; other site
86416001298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416001299	non-specific DNA binding site [nucleotide binding]; other site
86416001300	salt bridge; other site
86416001301	sequence-specific DNA binding site [nucleotide binding]; other site
86416001302	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
86416001303	Catalytic site [active]
86416001304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416001305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416001306	non-specific DNA binding site [nucleotide binding]; other site
86416001307	salt bridge; other site
86416001308	sequence-specific DNA binding site [nucleotide binding]; other site
86416001309	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416001310	Prophage antirepressor [Transcription]; Region: COG3617
86416001311	BRO family, N-terminal domain; Region: Bro-N; cl10591
86416001312	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
86416001313	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
86416001314	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
86416001315	active site
86416001316	DNA binding site [nucleotide binding]
86416001317	catalytic site [active]
86416001318	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
86416001319	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416001320	aspartate racemase; Region: asp_race; TIGR00035
86416001321	Virulence-associated protein E; Region: VirE; pfam05272
86416001322	VRR-NUC domain; Region: VRR_NUC; pfam08774
86416001323	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
86416001324	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
86416001325	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
86416001326	ATP binding site [chemical binding]; other site
86416001327	putative Mg++ binding site [ion binding]; other site
86416001328	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416001329	nucleotide binding region [chemical binding]; other site
86416001330	ATP-binding site [chemical binding]; other site
86416001331	Uncharacterized conserved protein [Function unknown]; Region: COG5484
86416001332	Phage terminase small subunit; Region: Phage_terminase; pfam10668
86416001333	Phage terminase large subunit; Region: Terminase_3; cl12054
86416001334	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
86416001335	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
86416001336	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
86416001337	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
86416001338	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
86416001339	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
86416001340	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
86416001341	Phage-related protein [Function unknown]; Region: COG5412
86416001342	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
86416001343	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
86416001344	active site
86416001345	oxyanion hole [active]
86416001346	Holin family; Region: Phage_holin_4; pfam05105
86416001347	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416001348	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416001349	active site
86416001350	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416001351	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416001352	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416001353	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
86416001354	4Fe-4S binding domain; Region: Fer4; cl02805
86416001355	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416001356	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
86416001357	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416001358	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
86416001359	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
86416001360	dimer interface [polypeptide binding]; other site
86416001361	active site
86416001362	glycine loop; other site
86416001363	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
86416001364	active site
86416001365	intersubunit interactions; other site
86416001366	catalytic residue [active]
86416001367	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
86416001368	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
86416001369	DNA binding residues [nucleotide binding]
86416001370	dimer interface [polypeptide binding]; other site
86416001371	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
86416001372	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
86416001373	putative active site [active]
86416001374	Uncharacterized conserved protein [Function unknown]; Region: COG2006
86416001375	Domain of unknown function (DUF362); Region: DUF362; pfam04015
86416001376	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416001377	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416001378	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
86416001379	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
86416001380	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416001381	catalytic residue [active]
86416001382	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416001383	dimerization interface [polypeptide binding]; other site
86416001384	putative DNA binding site [nucleotide binding]; other site
86416001385	putative Zn2+ binding site [ion binding]; other site
86416001386	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
86416001387	arsenical-resistance protein; Region: acr3; TIGR00832
86416001388	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
86416001389	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
86416001390	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416001391	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
86416001392	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
86416001393	active site residue [active]
86416001394	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
86416001395	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416001396	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
86416001397	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
86416001398	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
86416001399	Probable transposase; Region: OrfB_IS605; pfam01385
86416001400	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416001401	dimerization interface [polypeptide binding]; other site
86416001402	putative DNA binding site [nucleotide binding]; other site
86416001403	putative Zn2+ binding site [ion binding]; other site
86416001404	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
86416001405	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
86416001406	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
86416001407	P loop; other site
86416001408	Nucleotide binding site [chemical binding]; other site
86416001409	DTAP/Switch II; other site
86416001410	Switch I; other site
86416001411	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
86416001412	P loop; other site
86416001413	Nucleotide binding site [chemical binding]; other site
86416001414	DTAP/Switch II; other site
86416001415	Switch I; other site
86416001416	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
86416001417	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
86416001418	substrate binding [chemical binding]; other site
86416001419	active site
86416001420	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
86416001421	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
86416001422	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
86416001423	inhibitor-cofactor binding pocket; inhibition site
86416001424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416001425	catalytic residue [active]
86416001426	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416001427	MarR family; Region: MarR_2; pfam12802
86416001428	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416001429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416001430	S-adenosylmethionine binding site [chemical binding]; other site
86416001431	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
86416001432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416001433	Coenzyme A binding pocket [chemical binding]; other site
86416001434	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416001435	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416001436	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416001437	dimerization interface [polypeptide binding]; other site
86416001438	putative DNA binding site [nucleotide binding]; other site
86416001439	putative Zn2+ binding site [ion binding]; other site
86416001440	CAAX protease self-immunity; Region: Abi; pfam02517
86416001441	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
86416001442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416001443	active site
86416001444	phosphorylation site [posttranslational modification]
86416001445	intermolecular recognition site; other site
86416001446	LytTr DNA-binding domain; Region: LytTR; pfam04397
86416001447	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
86416001448	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416001449	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416001450	Walker A/P-loop; other site
86416001451	ATP binding site [chemical binding]; other site
86416001452	Q-loop/lid; other site
86416001453	ABC transporter signature motif; other site
86416001454	Walker B; other site
86416001455	D-loop; other site
86416001456	H-loop/switch region; other site
86416001457	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416001458	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416001459	FtsX-like permease family; Region: FtsX; pfam02687
86416001460	Yip1 domain; Region: Yip1; pfam04893
86416001461	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416001462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416001463	Coenzyme A binding pocket [chemical binding]; other site
86416001464	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
86416001465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416001466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416001467	active site
86416001468	phosphorylation site [posttranslational modification]
86416001469	intermolecular recognition site; other site
86416001470	dimerization interface [polypeptide binding]; other site
86416001471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416001472	DNA binding site [nucleotide binding]
86416001473	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416001474	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416001475	dimerization interface [polypeptide binding]; other site
86416001476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416001477	dimer interface [polypeptide binding]; other site
86416001478	phosphorylation site [posttranslational modification]
86416001479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416001480	ATP binding site [chemical binding]; other site
86416001481	Mg2+ binding site [ion binding]; other site
86416001482	G-X-G motif; other site
86416001483	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416001484	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
86416001485	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
86416001486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416001487	Walker A/P-loop; other site
86416001488	ATP binding site [chemical binding]; other site
86416001489	Q-loop/lid; other site
86416001490	ABC transporter signature motif; other site
86416001491	Walker B; other site
86416001492	D-loop; other site
86416001493	H-loop/switch region; other site
86416001494	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
86416001495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001496	putative substrate translocation pore; other site
86416001497	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
86416001498	pyruvate kinase; Provisional; Region: PRK14725
86416001499	active site
86416001500	FOG: CBS domain [General function prediction only]; Region: COG0517
86416001501	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
86416001502	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
86416001503	alpha-gamma subunit interface [polypeptide binding]; other site
86416001504	beta-gamma subunit interface [polypeptide binding]; other site
86416001505	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
86416001506	Uncharacterized conserved protein [Function unknown]; Region: COG1284
86416001507	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
86416001508	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
86416001509	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416001510	substrate binding pocket [chemical binding]; other site
86416001511	membrane-bound complex binding site; other site
86416001512	hinge residues; other site
86416001513	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
86416001514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001515	dimer interface [polypeptide binding]; other site
86416001516	conserved gate region; other site
86416001517	putative PBP binding loops; other site
86416001518	ABC-ATPase subunit interface; other site
86416001519	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
86416001520	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
86416001521	Walker A/P-loop; other site
86416001522	ATP binding site [chemical binding]; other site
86416001523	Q-loop/lid; other site
86416001524	ABC transporter signature motif; other site
86416001525	Walker B; other site
86416001526	D-loop; other site
86416001527	H-loop/switch region; other site
86416001528	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
86416001529	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416001530	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
86416001531	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
86416001532	active site residue [active]
86416001533	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
86416001534	CPxP  motif; other site
86416001535	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
86416001536	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416001537	dimerization interface [polypeptide binding]; other site
86416001538	putative DNA binding site [nucleotide binding]; other site
86416001539	putative Zn2+ binding site [ion binding]; other site
86416001540	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416001541	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416001542	NodB motif; other site
86416001543	active site
86416001544	catalytic site [active]
86416001545	Zn binding site [ion binding]; other site
86416001546	manganese transport protein MntH; Reviewed; Region: PRK00701
86416001547	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
86416001548	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416001549	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416001550	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416001551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
86416001552	SnoaL-like domain; Region: SnoaL_2; pfam12680
86416001553	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
86416001554	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
86416001555	active site
86416001556	trimer interface [polypeptide binding]; other site
86416001557	allosteric site; other site
86416001558	active site lid [active]
86416001559	hexamer (dimer of trimers) interface [polypeptide binding]; other site
86416001560	LysE type translocator; Region: LysE; cl00565
86416001561	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
86416001562	active site
86416001563	catalytic residues [active]
86416001564	metal binding site [ion binding]; metal-binding site
86416001565	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
86416001566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416001567	Walker A/P-loop; other site
86416001568	ATP binding site [chemical binding]; other site
86416001569	Q-loop/lid; other site
86416001570	ABC transporter signature motif; other site
86416001571	Walker B; other site
86416001572	D-loop; other site
86416001573	H-loop/switch region; other site
86416001574	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
86416001575	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
86416001576	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
86416001577	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
86416001578	active site
86416001579	ATP binding site [chemical binding]; other site
86416001580	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416001581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416001582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416001583	Coenzyme A binding pocket [chemical binding]; other site
86416001584	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416001585	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
86416001586	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
86416001587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416001588	motif II; other site
86416001589	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
86416001590	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
86416001591	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416001592	Walker A/P-loop; other site
86416001593	ATP binding site [chemical binding]; other site
86416001594	Q-loop/lid; other site
86416001595	ABC transporter signature motif; other site
86416001596	Walker B; other site
86416001597	D-loop; other site
86416001598	H-loop/switch region; other site
86416001599	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416001600	Walker A/P-loop; other site
86416001601	ATP binding site [chemical binding]; other site
86416001602	Q-loop/lid; other site
86416001603	ABC transporter signature motif; other site
86416001604	Walker B; other site
86416001605	D-loop; other site
86416001606	H-loop/switch region; other site
86416001607	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
86416001608	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
86416001609	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
86416001610	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416001611	Walker A/P-loop; other site
86416001612	ATP binding site [chemical binding]; other site
86416001613	Q-loop/lid; other site
86416001614	ABC transporter signature motif; other site
86416001615	Walker B; other site
86416001616	D-loop; other site
86416001617	H-loop/switch region; other site
86416001618	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
86416001619	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416001620	Walker A/P-loop; other site
86416001621	ATP binding site [chemical binding]; other site
86416001622	Q-loop/lid; other site
86416001623	ABC transporter signature motif; other site
86416001624	Walker B; other site
86416001625	D-loop; other site
86416001626	H-loop/switch region; other site
86416001627	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
86416001628	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416001629	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416001630	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416001631	putative active site [active]
86416001632	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
86416001633	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
86416001634	active site
86416001635	PHP-associated; Region: PHP_C; pfam13263
86416001636	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
86416001637	Uncharacterized conserved protein [Function unknown]; Region: COG2454
86416001638	Fic/DOC family; Region: Fic; pfam02661
86416001639	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416001640	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
86416001641	active site
86416001642	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
86416001643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416001644	FeS/SAM binding site; other site
86416001645	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
86416001646	putative FMN binding site [chemical binding]; other site
86416001647	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416001648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001649	dimer interface [polypeptide binding]; other site
86416001650	conserved gate region; other site
86416001651	putative PBP binding loops; other site
86416001652	ABC-ATPase subunit interface; other site
86416001653	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
86416001654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416001655	Walker A/P-loop; other site
86416001656	ATP binding site [chemical binding]; other site
86416001657	Q-loop/lid; other site
86416001658	ABC transporter signature motif; other site
86416001659	Walker B; other site
86416001660	D-loop; other site
86416001661	H-loop/switch region; other site
86416001662	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416001663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001664	putative PBP binding loops; other site
86416001665	dimer interface [polypeptide binding]; other site
86416001666	ABC-ATPase subunit interface; other site
86416001667	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416001668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001669	dimer interface [polypeptide binding]; other site
86416001670	conserved gate region; other site
86416001671	putative PBP binding loops; other site
86416001672	ABC-ATPase subunit interface; other site
86416001673	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416001674	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
86416001675	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
86416001676	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
86416001677	active site
86416001678	catalytic site [active]
86416001679	metal binding site [ion binding]; metal-binding site
86416001680	dimer interface [polypeptide binding]; other site
86416001681	drug efflux system protein MdtG; Provisional; Region: PRK09874
86416001682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001683	putative substrate translocation pore; other site
86416001684	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
86416001685	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
86416001686	dimer interface [polypeptide binding]; other site
86416001687	motif 1; other site
86416001688	active site
86416001689	motif 2; other site
86416001690	motif 3; other site
86416001691	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
86416001692	anticodon binding site; other site
86416001693	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
86416001694	Melibiase; Region: Melibiase; pfam02065
86416001695	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
86416001696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416001697	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416001698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416001699	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
86416001700	active site
86416001701	catalytic residues [active]
86416001702	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
86416001703	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416001704	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416001705	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416001706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001707	putative PBP binding loops; other site
86416001708	ABC-ATPase subunit interface; other site
86416001709	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416001710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416001711	dimer interface [polypeptide binding]; other site
86416001712	conserved gate region; other site
86416001713	putative PBP binding loops; other site
86416001714	ABC-ATPase subunit interface; other site
86416001715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416001716	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416001717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416001718	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
86416001719	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
86416001720	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
86416001721	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
86416001722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416001723	DNA binding site [nucleotide binding]
86416001724	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
86416001725	putative dimerization interface [polypeptide binding]; other site
86416001726	putative ligand binding site [chemical binding]; other site
86416001727	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
86416001728	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
86416001729	galactokinase; Provisional; Region: PRK05322
86416001730	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
86416001731	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
86416001732	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
86416001733	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
86416001734	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
86416001735	NAD binding site [chemical binding]; other site
86416001736	homodimer interface [polypeptide binding]; other site
86416001737	active site
86416001738	substrate binding site [chemical binding]; other site
86416001739	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416001740	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416001741	DNA binding site [nucleotide binding]
86416001742	domain linker motif; other site
86416001743	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416001744	dimerization interface [polypeptide binding]; other site
86416001745	ligand binding site [chemical binding]; other site
86416001746	Family description; Region: VCBS; pfam13517
86416001747	Family description; Region: VCBS; pfam13517
86416001748	Family description; Region: VCBS; pfam13517
86416001749	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416001750	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416001751	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416001752	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
86416001753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416001754	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
86416001755	Walker A motif; other site
86416001756	ATP binding site [chemical binding]; other site
86416001757	Walker B motif; other site
86416001758	arginine finger; other site
86416001759	PRD domain; Region: PRD; pfam00874
86416001760	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416001761	active pocket/dimerization site; other site
86416001762	active site
86416001763	phosphorylation site [posttranslational modification]
86416001764	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416001765	active site
86416001766	phosphorylation site [posttranslational modification]
86416001767	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
86416001768	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
86416001769	active site
86416001770	intersubunit interface [polypeptide binding]; other site
86416001771	catalytic residue [active]
86416001772	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416001773	active site
86416001774	phosphorylation site [posttranslational modification]
86416001775	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
86416001776	active site
86416001777	P-loop; other site
86416001778	phosphorylation site [posttranslational modification]
86416001779	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
86416001780	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
86416001781	galactonate dehydratase; Provisional; Region: PRK14017
86416001782	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
86416001783	putative active site pocket [active]
86416001784	putative metal binding site [ion binding]; other site
86416001785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
86416001786	sequence-specific DNA binding site [nucleotide binding]; other site
86416001787	salt bridge; other site
86416001788	Cupin domain; Region: Cupin_2; pfam07883
86416001789	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
86416001790	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
86416001791	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416001792	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416001793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416001794	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416001795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
86416001796	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416001797	MULE transposase domain; Region: MULE; pfam10551
86416001798	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
86416001799	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416001800	Transcriptional regulator PadR-like family; Region: PadR; cl17335
86416001801	Predicted transcriptional regulators [Transcription]; Region: COG1725
86416001802	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416001803	DNA-binding site [nucleotide binding]; DNA binding site
86416001804	Predicted membrane protein [General function prediction only]; Region: COG4194
86416001805	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
86416001806	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
86416001807	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416001808	active site 1 [active]
86416001809	dimer interface [polypeptide binding]; other site
86416001810	hexamer interface [polypeptide binding]; other site
86416001811	active site 2 [active]
86416001812	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
86416001813	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416001814	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416001815	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416001816	MarR family; Region: MarR_2; pfam12802
86416001817	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
86416001818	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
86416001819	oligomer interface [polypeptide binding]; other site
86416001820	metal binding site [ion binding]; metal-binding site
86416001821	metal binding site [ion binding]; metal-binding site
86416001822	putative Cl binding site [ion binding]; other site
86416001823	aspartate ring; other site
86416001824	basic sphincter; other site
86416001825	hydrophobic gate; other site
86416001826	periplasmic entrance; other site
86416001827	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416001828	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
86416001829	catalytic residues [active]
86416001830	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
86416001831	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
86416001832	heme binding pocket [chemical binding]; other site
86416001833	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416001834	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
86416001835	putative active site [active]
86416001836	putative metal binding site [ion binding]; other site
86416001837	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
86416001838	YCII-related domain; Region: YCII; cl00999
86416001839	4-aminobutyrate aminotransferase, prokaryotic type; Region: GABAtrnsam; TIGR00700
86416001840	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
86416001841	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416001842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416001843	homodimer interface [polypeptide binding]; other site
86416001844	catalytic residue [active]
86416001845	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
86416001846	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
86416001847	active site
86416001848	HIGH motif; other site
86416001849	dimer interface [polypeptide binding]; other site
86416001850	KMSKS motif; other site
86416001851	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416001852	RNA binding surface [nucleotide binding]; other site
86416001853	Protein of unknown function DUF86; Region: DUF86; pfam01934
86416001854	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
86416001855	active site
86416001856	NTP binding site [chemical binding]; other site
86416001857	metal binding triad [ion binding]; metal-binding site
86416001858	antibiotic binding site [chemical binding]; other site
86416001859	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416001860	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416001861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001863	WHG domain; Region: WHG; pfam13305
86416001864	drug efflux system protein MdtG; Provisional; Region: PRK09874
86416001865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001866	putative substrate translocation pore; other site
86416001867	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416001868	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416001869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416001870	Isochorismatase family; Region: Isochorismatase; pfam00857
86416001871	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
86416001872	catalytic triad [active]
86416001873	conserved cis-peptide bond; other site
86416001874	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
86416001875	polypeptide substrate binding site [polypeptide binding]; other site
86416001876	active site
86416001877	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416001878	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416001879	active site
86416001880	TDP-binding site; other site
86416001881	acceptor substrate-binding pocket; other site
86416001882	homodimer interface [polypeptide binding]; other site
86416001883	Predicted membrane protein [Function unknown]; Region: COG3619
86416001884	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416001885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416001886	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416001887	dimerization interface [polypeptide binding]; other site
86416001888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001890	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416001891	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416001892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001893	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416001894	putative substrate translocation pore; other site
86416001895	4Fe-4S binding domain; Region: Fer4; pfam00037
86416001896	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416001897	4Fe-4S binding domain; Region: Fer4; pfam00037
86416001898	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
86416001899	putative FMN binding site [chemical binding]; other site
86416001900	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416001901	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416001902	DNA binding residues [nucleotide binding]
86416001903	putative dimer interface [polypeptide binding]; other site
86416001904	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
86416001905	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416001906	active site
86416001907	catalytic tetrad [active]
86416001908	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416001909	hypothetical protein; Provisional; Region: PRK04194
86416001910	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
86416001911	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
86416001912	Ligand Binding Site [chemical binding]; other site
86416001913	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
86416001914	AIR carboxylase; Region: AIRC; smart01001
86416001915	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
86416001916	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
86416001917	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416001918	Walker A/P-loop; other site
86416001919	ATP binding site [chemical binding]; other site
86416001920	Q-loop/lid; other site
86416001921	ABC transporter signature motif; other site
86416001922	Walker B; other site
86416001923	D-loop; other site
86416001924	H-loop/switch region; other site
86416001925	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
86416001926	PLD-like domain; Region: PLDc_2; pfam13091
86416001927	putative active site [active]
86416001928	catalytic site [active]
86416001929	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
86416001930	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416001931	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416001932	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
86416001933	cobalt transport protein CbiM; Validated; Region: PRK08319
86416001934	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
86416001935	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416001936	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
86416001937	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
86416001938	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
86416001939	NAD binding site [chemical binding]; other site
86416001940	substrate binding site [chemical binding]; other site
86416001941	active site
86416001942	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
86416001943	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
86416001944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416001945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416001946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001947	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416001948	putative substrate translocation pore; other site
86416001949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001950	TM2 domain; Region: TM2; pfam05154
86416001951	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416001952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416001953	putative substrate translocation pore; other site
86416001954	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
86416001955	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
86416001956	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
86416001957	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
86416001958	dimer interface [polypeptide binding]; other site
86416001959	putative CheW interface [polypeptide binding]; other site
86416001960	biotin synthase; Region: bioB; TIGR00433
86416001961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416001962	FeS/SAM binding site; other site
86416001963	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
86416001964	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
86416001965	Transcriptional regulator [Transcription]; Region: LytR; COG1316
86416001966	Coat F domain; Region: Coat_F; pfam07875
86416001967	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
86416001968	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
86416001969	Spore germination protein; Region: Spore_permease; cl17796
86416001970	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
86416001971	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
86416001972	Propionate catabolism activator; Region: PrpR_N; pfam06506
86416001973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416001974	putative active site [active]
86416001975	heme pocket [chemical binding]; other site
86416001976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416001977	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
86416001978	Walker A motif; other site
86416001979	ATP binding site [chemical binding]; other site
86416001980	Walker B motif; other site
86416001981	arginine finger; other site
86416001982	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
86416001983	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
86416001984	inhibitor site; inhibition site
86416001985	active site
86416001986	dimer interface [polypeptide binding]; other site
86416001987	catalytic residue [active]
86416001988	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
86416001989	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
86416001990	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
86416001991	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
86416001992	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
86416001993	SEC-C motif; Region: SEC-C; pfam02810
86416001994	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
86416001995	active site
86416001996	catalytic site [active]
86416001997	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
86416001998	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
86416001999	NAD binding site [chemical binding]; other site
86416002000	homodimer interface [polypeptide binding]; other site
86416002001	active site
86416002002	substrate binding site [chemical binding]; other site
86416002003	Transcriptional regulator [Transcription]; Region: LytR; COG1316
86416002004	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
86416002005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416002006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416002007	dimer interface [polypeptide binding]; other site
86416002008	phosphorylation site [posttranslational modification]
86416002009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002010	Response regulator receiver domain; Region: Response_reg; pfam00072
86416002011	active site
86416002012	phosphorylation site [posttranslational modification]
86416002013	intermolecular recognition site; other site
86416002014	dimerization interface [polypeptide binding]; other site
86416002015	Histidine kinase; Region: His_kinase; pfam06580
86416002016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002017	ATP binding site [chemical binding]; other site
86416002018	Mg2+ binding site [ion binding]; other site
86416002019	G-X-G motif; other site
86416002020	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
86416002021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002022	active site
86416002023	phosphorylation site [posttranslational modification]
86416002024	intermolecular recognition site; other site
86416002025	dimerization interface [polypeptide binding]; other site
86416002026	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
86416002027	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
86416002028	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002029	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416002030	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002031	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
86416002032	putative ADP-binding pocket [chemical binding]; other site
86416002033	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002034	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
86416002035	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
86416002036	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416002037	active site
86416002038	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
86416002039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416002040	active site
86416002041	Chain length determinant protein; Region: Wzz; cl15801
86416002042	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
86416002043	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
86416002044	Chain length determinant protein; Region: Wzz; cl15801
86416002045	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
86416002046	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416002047	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
86416002048	Bacterial sugar transferase; Region: Bac_transf; pfam02397
86416002049	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
86416002050	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
86416002051	Substrate binding site; other site
86416002052	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
86416002053	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
86416002054	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
86416002055	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
86416002056	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
86416002057	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
86416002058	NADP binding site [chemical binding]; other site
86416002059	active site
86416002060	putative substrate binding site [chemical binding]; other site
86416002061	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
86416002062	Bacterial sugar transferase; Region: Bac_transf; pfam02397
86416002063	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
86416002064	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
86416002065	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
86416002066	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
86416002067	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002068	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
86416002069	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
86416002070	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
86416002071	trimer interface [polypeptide binding]; other site
86416002072	active site
86416002073	substrate binding site [chemical binding]; other site
86416002074	CoA binding site [chemical binding]; other site
86416002075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002076	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
86416002077	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
86416002078	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416002079	active site
86416002080	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416002081	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
86416002082	putative ADP-binding pocket [chemical binding]; other site
86416002083	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
86416002084	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416002085	active site
86416002086	putative glycosyl transferase; Provisional; Region: PRK10073
86416002087	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416002088	active site
86416002089	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
86416002090	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
86416002091	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
86416002092	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
86416002093	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
86416002094	trimer interface [polypeptide binding]; other site
86416002095	active site
86416002096	substrate binding site [chemical binding]; other site
86416002097	CoA binding site [chemical binding]; other site
86416002098	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
86416002099	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
86416002100	trimer interface [polypeptide binding]; other site
86416002101	active site
86416002102	substrate binding site [chemical binding]; other site
86416002103	CoA binding site [chemical binding]; other site
86416002104	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
86416002105	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
86416002106	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
86416002107	substrate binding site; other site
86416002108	tetramer interface; other site
86416002109	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
86416002110	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
86416002111	NAD binding site [chemical binding]; other site
86416002112	substrate binding site [chemical binding]; other site
86416002113	homodimer interface [polypeptide binding]; other site
86416002114	active site
86416002115	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
86416002116	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
86416002117	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
86416002118	active site
86416002119	tetramer interface; other site
86416002120	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
86416002121	Transposase IS200 like; Region: Y1_Tnp; pfam01797
86416002122	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
86416002123	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
86416002124	active site
86416002125	tetramer interface; other site
86416002126	Chain length determinant protein; Region: Wzz; cl15801
86416002127	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
86416002128	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
86416002129	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416002130	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
86416002131	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
86416002132	active site
86416002133	substrate binding site [chemical binding]; other site
86416002134	metal binding site [ion binding]; metal-binding site
86416002135	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
86416002136	active site
86416002137	catalytic residues [active]
86416002138	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416002139	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416002140	FtsX-like permease family; Region: FtsX; pfam02687
86416002141	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416002142	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416002143	Walker A/P-loop; other site
86416002144	ATP binding site [chemical binding]; other site
86416002145	Q-loop/lid; other site
86416002146	ABC transporter signature motif; other site
86416002147	Walker B; other site
86416002148	D-loop; other site
86416002149	H-loop/switch region; other site
86416002150	Chain length determinant protein; Region: Wzz; cl15801
86416002151	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
86416002152	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
86416002153	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416002154	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
86416002155	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
86416002156	O-Antigen ligase; Region: Wzy_C; pfam04932
86416002157	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
86416002158	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416002159	phosphate binding site [ion binding]; other site
86416002160	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416002161	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416002162	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
86416002163	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
86416002164	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416002165	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416002166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416002167	DNA binding residues [nucleotide binding]
86416002168	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416002169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416002170	non-specific DNA binding site [nucleotide binding]; other site
86416002171	salt bridge; other site
86416002172	sequence-specific DNA binding site [nucleotide binding]; other site
86416002173	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416002174	Bacterial SH3 domain; Region: SH3_3; pfam08239
86416002175	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416002176	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416002177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002178	putative transporter; Provisional; Region: PRK10504
86416002179	putative substrate translocation pore; other site
86416002180	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
86416002181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416002182	FeS/SAM binding site; other site
86416002183	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
86416002184	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
86416002185	peptidase domain interface [polypeptide binding]; other site
86416002186	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
86416002187	active site
86416002188	catalytic triad [active]
86416002189	calcium binding site [ion binding]; other site
86416002190	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
86416002191	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
86416002192	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
86416002193	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
86416002194	substrate binding [chemical binding]; other site
86416002195	active site
86416002196	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
86416002197	Cna protein B-type domain; Region: Cna_B; pfam05738
86416002198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
86416002199	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
86416002200	PAS fold; Region: PAS_4; pfam08448
86416002201	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416002202	putative active site [active]
86416002203	heme pocket [chemical binding]; other site
86416002204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416002205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416002206	dimer interface [polypeptide binding]; other site
86416002207	phosphorylation site [posttranslational modification]
86416002208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002209	ATP binding site [chemical binding]; other site
86416002210	Mg2+ binding site [ion binding]; other site
86416002211	G-X-G motif; other site
86416002212	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
86416002213	PAS fold; Region: PAS; pfam00989
86416002214	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416002215	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416002216	dimer interface [polypeptide binding]; other site
86416002217	phosphorylation site [posttranslational modification]
86416002218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002219	ATP binding site [chemical binding]; other site
86416002220	Mg2+ binding site [ion binding]; other site
86416002221	G-X-G motif; other site
86416002222	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416002223	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416002224	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
86416002225	putative active site [active]
86416002226	Zn binding site [ion binding]; other site
86416002227	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
86416002228	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416002229	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416002230	homodimer interface [polypeptide binding]; other site
86416002231	catalytic residue [active]
86416002232	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
86416002233	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
86416002234	Membrane protein of unknown function; Region: DUF360; pfam04020
86416002235	YvrJ protein family; Region: YvrJ; pfam12841
86416002236	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
86416002237	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
86416002238	active site
86416002239	tetramer interface; other site
86416002240	Sensory domain found in PocR; Region: PocR; pfam10114
86416002241	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
86416002242	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
86416002243	Histidine kinase; Region: His_kinase; pfam06580
86416002244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002245	ATP binding site [chemical binding]; other site
86416002246	Mg2+ binding site [ion binding]; other site
86416002247	G-X-G motif; other site
86416002248	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
86416002249	amphipathic channel; other site
86416002250	Asn-Pro-Ala signature motifs; other site
86416002251	Response regulator receiver domain; Region: Response_reg; pfam00072
86416002252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002253	active site
86416002254	phosphorylation site [posttranslational modification]
86416002255	intermolecular recognition site; other site
86416002256	dimerization interface [polypeptide binding]; other site
86416002257	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416002258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416002259	glycerol kinase; Provisional; Region: glpK; PRK00047
86416002260	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
86416002261	N- and C-terminal domain interface [polypeptide binding]; other site
86416002262	active site
86416002263	MgATP binding site [chemical binding]; other site
86416002264	catalytic site [active]
86416002265	metal binding site [ion binding]; metal-binding site
86416002266	glycerol binding site [chemical binding]; other site
86416002267	homotetramer interface [polypeptide binding]; other site
86416002268	homodimer interface [polypeptide binding]; other site
86416002269	FBP binding site [chemical binding]; other site
86416002270	protein IIAGlc interface [polypeptide binding]; other site
86416002271	Predicted dehydrogenase [General function prediction only]; Region: COG0579
86416002272	hydroxyglutarate oxidase; Provisional; Region: PRK11728
86416002273	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
86416002274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
86416002275	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
86416002276	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
86416002277	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
86416002278	HPr interaction site; other site
86416002279	active site
86416002280	phosphorylation site [posttranslational modification]
86416002281	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
86416002282	PKC phosphorylation site [posttranslational modification]; other site
86416002283	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416002284	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416002285	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416002286	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
86416002287	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416002288	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
86416002289	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416002290	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416002291	Soluble P-type ATPase [General function prediction only]; Region: COG4087
86416002292	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416002293	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
86416002294	epoxyqueuosine reductase; Region: TIGR00276
86416002295	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416002296	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416002297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002298	dimer interface [polypeptide binding]; other site
86416002299	conserved gate region; other site
86416002300	putative PBP binding loops; other site
86416002301	ABC-ATPase subunit interface; other site
86416002302	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416002303	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416002304	Walker A/P-loop; other site
86416002305	ATP binding site [chemical binding]; other site
86416002306	Q-loop/lid; other site
86416002307	ABC transporter signature motif; other site
86416002308	Walker B; other site
86416002309	D-loop; other site
86416002310	H-loop/switch region; other site
86416002311	NMT1/THI5 like; Region: NMT1; pfam09084
86416002312	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416002313	substrate binding pocket [chemical binding]; other site
86416002314	membrane-bound complex binding site; other site
86416002315	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
86416002316	dimer interface [polypeptide binding]; other site
86416002317	ADP-ribose binding site [chemical binding]; other site
86416002318	active site
86416002319	nudix motif; other site
86416002320	metal binding site [ion binding]; metal-binding site
86416002321	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
86416002322	Cytochrome P450; Region: p450; cl12078
86416002323	MarR family; Region: MarR_2; cl17246
86416002324	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416002325	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
86416002326	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
86416002327	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
86416002328	dimer interface [polypeptide binding]; other site
86416002329	active site
86416002330	glycine loop; other site
86416002331	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
86416002332	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416002333	FeS/SAM binding site; other site
86416002334	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416002335	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416002336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002337	dimer interface [polypeptide binding]; other site
86416002338	conserved gate region; other site
86416002339	putative PBP binding loops; other site
86416002340	ABC-ATPase subunit interface; other site
86416002341	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416002342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002343	dimer interface [polypeptide binding]; other site
86416002344	conserved gate region; other site
86416002345	putative PBP binding loops; other site
86416002346	ABC-ATPase subunit interface; other site
86416002347	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
86416002348	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416002349	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
86416002350	active site
86416002351	metal binding site [ion binding]; metal-binding site
86416002352	transketolase; Reviewed; Region: PRK05899
86416002353	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
86416002354	TPP-binding site [chemical binding]; other site
86416002355	dimer interface [polypeptide binding]; other site
86416002356	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
86416002357	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
86416002358	PYR/PP interface [polypeptide binding]; other site
86416002359	dimer interface [polypeptide binding]; other site
86416002360	TPP binding site [chemical binding]; other site
86416002361	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416002362	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
86416002363	hexamer (dimer of trimers) interface [polypeptide binding]; other site
86416002364	trimer interface [polypeptide binding]; other site
86416002365	substrate binding site [chemical binding]; other site
86416002366	Mn binding site [ion binding]; other site
86416002367	alpha-glucosidase; Provisional; Region: PRK10426
86416002368	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
86416002369	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
86416002370	putative active site [active]
86416002371	putative catalytic site [active]
86416002372	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
86416002373	PAS fold; Region: PAS_4; pfam08448
86416002374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416002375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416002376	dimer interface [polypeptide binding]; other site
86416002377	phosphorylation site [posttranslational modification]
86416002378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002379	ATP binding site [chemical binding]; other site
86416002380	Mg2+ binding site [ion binding]; other site
86416002381	G-X-G motif; other site
86416002382	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
86416002383	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
86416002384	EamA-like transporter family; Region: EamA; pfam00892
86416002385	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416002386	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416002387	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416002388	DNA binding residues [nucleotide binding]
86416002389	Fic family protein [Function unknown]; Region: COG3177
86416002390	Fic/DOC family; Region: Fic; pfam02661
86416002391	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
86416002392	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
86416002393	NAD(P) binding site [chemical binding]; other site
86416002394	homotetramer interface [polypeptide binding]; other site
86416002395	homodimer interface [polypeptide binding]; other site
86416002396	active site
86416002397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416002398	non-specific DNA binding site [nucleotide binding]; other site
86416002399	salt bridge; other site
86416002400	sequence-specific DNA binding site [nucleotide binding]; other site
86416002401	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416002402	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416002403	active site
86416002404	catalytic tetrad [active]
86416002405	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
86416002406	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
86416002407	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416002408	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416002409	Protein of unknown function (DUF998); Region: DUF998; pfam06197
86416002410	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
86416002411	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
86416002412	Bacteriophage holin; Region: Phage_holin_1; cl02344
86416002413	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
86416002414	active site
86416002415	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416002416	FtsX-like permease family; Region: FtsX; pfam02687
86416002417	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416002418	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416002419	Walker A/P-loop; other site
86416002420	ATP binding site [chemical binding]; other site
86416002421	Q-loop/lid; other site
86416002422	ABC transporter signature motif; other site
86416002423	Walker B; other site
86416002424	D-loop; other site
86416002425	H-loop/switch region; other site
86416002426	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416002427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002428	active site
86416002429	phosphorylation site [posttranslational modification]
86416002430	intermolecular recognition site; other site
86416002431	dimerization interface [polypeptide binding]; other site
86416002432	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416002433	DNA binding site [nucleotide binding]
86416002434	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
86416002435	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416002436	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
86416002437	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416002438	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416002439	Walker A/P-loop; other site
86416002440	ATP binding site [chemical binding]; other site
86416002441	Q-loop/lid; other site
86416002442	ABC transporter signature motif; other site
86416002443	Walker B; other site
86416002444	D-loop; other site
86416002445	H-loop/switch region; other site
86416002446	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
86416002447	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416002448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002449	active site
86416002450	phosphorylation site [posttranslational modification]
86416002451	intermolecular recognition site; other site
86416002452	dimerization interface [polypeptide binding]; other site
86416002453	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416002454	DNA binding site [nucleotide binding]
86416002455	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
86416002456	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
86416002457	Probable transposase; Region: OrfB_IS605; pfam01385
86416002458	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
86416002459	PemK-like protein; Region: PemK; pfam02452
86416002460	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
86416002461	MPT binding site; other site
86416002462	trimer interface [polypeptide binding]; other site
86416002463	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
86416002464	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
86416002465	[4Fe-4S] binding site [ion binding]; other site
86416002466	molybdopterin cofactor binding site; other site
86416002467	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
86416002468	molybdopterin cofactor binding site; other site
86416002469	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
86416002470	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
86416002471	dimer interface [polypeptide binding]; other site
86416002472	putative functional site; other site
86416002473	putative MPT binding site; other site
86416002474	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
86416002475	Walker A motif; other site
86416002476	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
86416002477	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416002478	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
86416002479	4Fe-4S binding domain; Region: Fer4; cl02805
86416002480	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
86416002481	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
86416002482	GTP binding site; other site
86416002483	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
86416002484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416002485	FeS/SAM binding site; other site
86416002486	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
86416002487	MOSC domain; Region: MOSC; pfam03473
86416002488	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
86416002489	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416002490	putative active site [active]
86416002491	putative metal binding site [ion binding]; other site
86416002492	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
86416002493	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416002494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002495	active site
86416002496	phosphorylation site [posttranslational modification]
86416002497	intermolecular recognition site; other site
86416002498	dimerization interface [polypeptide binding]; other site
86416002499	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416002500	DNA binding site [nucleotide binding]
86416002501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416002502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
86416002503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416002504	ATP binding site [chemical binding]; other site
86416002505	Mg2+ binding site [ion binding]; other site
86416002506	G-X-G motif; other site
86416002507	CAAX protease self-immunity; Region: Abi; pfam02517
86416002508	Accessory gene regulator B; Region: AgrB; cl01873
86416002509	putative transposase OrfB; Reviewed; Region: PHA02517
86416002510	HTH-like domain; Region: HTH_21; pfam13276
86416002511	Integrase core domain; Region: rve; pfam00665
86416002512	Integrase core domain; Region: rve_3; pfam13683
86416002513	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
86416002514	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
86416002515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416002516	active site
86416002517	phosphorylation site [posttranslational modification]
86416002518	intermolecular recognition site; other site
86416002519	dimerization interface [polypeptide binding]; other site
86416002520	LytTr DNA-binding domain; Region: LytTR; pfam04397
86416002521	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
86416002522	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
86416002523	ATP binding site [chemical binding]; other site
86416002524	Mg2+ binding site [ion binding]; other site
86416002525	G-X-G motif; other site
86416002526	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
86416002527	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416002528	FeS/SAM binding site; other site
86416002529	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
86416002530	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
86416002531	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
86416002532	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416002533	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416002534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416002535	Walker A/P-loop; other site
86416002536	ATP binding site [chemical binding]; other site
86416002537	Q-loop/lid; other site
86416002538	ABC transporter signature motif; other site
86416002539	Walker B; other site
86416002540	D-loop; other site
86416002541	H-loop/switch region; other site
86416002542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416002543	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416002544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002545	dimer interface [polypeptide binding]; other site
86416002546	conserved gate region; other site
86416002547	putative PBP binding loops; other site
86416002548	ABC-ATPase subunit interface; other site
86416002549	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416002550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002551	dimer interface [polypeptide binding]; other site
86416002552	conserved gate region; other site
86416002553	putative PBP binding loops; other site
86416002554	ABC-ATPase subunit interface; other site
86416002555	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
86416002556	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
86416002557	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416002558	Predicted membrane protein [Function unknown]; Region: COG1511
86416002559	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
86416002560	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
86416002561	Predicted membrane protein [Function unknown]; Region: COG1511
86416002562	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
86416002563	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
86416002564	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416002565	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416002566	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
86416002567	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416002568	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416002569	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416002570	molybdenum-pterin binding domain; Region: Mop; TIGR00638
86416002571	CAT RNA binding domain; Region: CAT_RBD; pfam03123
86416002572	transcriptional antiterminator BglG; Provisional; Region: PRK09772
86416002573	PRD domain; Region: PRD; pfam00874
86416002574	PRD domain; Region: PRD; pfam00874
86416002575	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
86416002576	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416002577	active site turn [active]
86416002578	phosphorylation site [posttranslational modification]
86416002579	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416002580	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416002581	HPr interaction site; other site
86416002582	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416002583	active site
86416002584	phosphorylation site [posttranslational modification]
86416002585	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
86416002586	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
86416002587	substrate binding [chemical binding]; other site
86416002588	active site
86416002589	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
86416002590	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
86416002591	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416002592	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416002593	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
86416002594	iron binding site [ion binding]; other site
86416002595	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
86416002596	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416002597	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
86416002598	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
86416002599	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
86416002600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002601	dimer interface [polypeptide binding]; other site
86416002602	conserved gate region; other site
86416002603	putative PBP binding loops; other site
86416002604	ABC-ATPase subunit interface; other site
86416002605	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
86416002606	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
86416002607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002608	dimer interface [polypeptide binding]; other site
86416002609	conserved gate region; other site
86416002610	putative PBP binding loops; other site
86416002611	ABC-ATPase subunit interface; other site
86416002612	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
86416002613	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416002614	Walker A/P-loop; other site
86416002615	ATP binding site [chemical binding]; other site
86416002616	Q-loop/lid; other site
86416002617	ABC transporter signature motif; other site
86416002618	Walker B; other site
86416002619	D-loop; other site
86416002620	H-loop/switch region; other site
86416002621	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
86416002622	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
86416002623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416002624	Walker A/P-loop; other site
86416002625	ATP binding site [chemical binding]; other site
86416002626	Q-loop/lid; other site
86416002627	ABC transporter signature motif; other site
86416002628	Walker B; other site
86416002629	D-loop; other site
86416002630	H-loop/switch region; other site
86416002631	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
86416002632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416002633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002635	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416002636	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
86416002637	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
86416002638	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
86416002639	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416002640	guanine deaminase; Region: guan_deamin; TIGR02967
86416002641	active site
86416002642	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
86416002643	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
86416002644	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416002645	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
86416002646	active site
86416002647	NAD binding site [chemical binding]; other site
86416002648	metal binding site [ion binding]; metal-binding site
86416002649	hypothetical protein; Provisional; Region: PRK06062
86416002650	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
86416002651	inhibitor-cofactor binding pocket; inhibition site
86416002652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416002653	catalytic residue [active]
86416002654	allantoate amidohydrolase; Reviewed; Region: PRK09290
86416002655	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
86416002656	active site
86416002657	metal binding site [ion binding]; metal-binding site
86416002658	dimer interface [polypeptide binding]; other site
86416002659	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
86416002660	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
86416002661	Na binding site [ion binding]; other site
86416002662	putative substrate binding site [chemical binding]; other site
86416002663	phenylhydantoinase; Validated; Region: PRK08323
86416002664	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
86416002665	tetramer interface [polypeptide binding]; other site
86416002666	active site
86416002667	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
86416002668	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
86416002669	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
86416002670	homodimer interface [polypeptide binding]; other site
86416002671	active site
86416002672	FMN binding site [chemical binding]; other site
86416002673	substrate binding site [chemical binding]; other site
86416002674	4Fe-4S binding domain; Region: Fer4; pfam00037
86416002675	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
86416002676	nitrogenase iron protein; Region: nifH; TIGR01287
86416002677	Nucleotide-binding sites [chemical binding]; other site
86416002678	Walker A motif; other site
86416002679	Switch I region of nucleotide binding site; other site
86416002680	Fe4S4 binding sites [ion binding]; other site
86416002681	Switch II region of nucleotide binding site; other site
86416002682	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416002683	PBP superfamily domain; Region: PBP_like; pfam12727
86416002684	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
86416002685	Predicted periplasmic protein [Function unknown]; Region: COG3698
86416002686	rod shape-determining protein MreB; Provisional; Region: PRK13927
86416002687	MreB and similar proteins; Region: MreB_like; cd10225
86416002688	nucleotide binding site [chemical binding]; other site
86416002689	Mg binding site [ion binding]; other site
86416002690	putative protofilament interaction site [polypeptide binding]; other site
86416002691	RodZ interaction site [polypeptide binding]; other site
86416002692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416002693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416002694	WHG domain; Region: WHG; pfam13305
86416002695	FMN-binding domain; Region: FMN_bind; cl01081
86416002696	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
86416002697	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416002698	Zn2+ binding site [ion binding]; other site
86416002699	Mg2+ binding site [ion binding]; other site
86416002700	Predicted amidohydrolase [General function prediction only]; Region: COG0388
86416002701	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
86416002702	active site
86416002703	catalytic triad [active]
86416002704	dimer interface [polypeptide binding]; other site
86416002705	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
86416002706	nudix motif; other site
86416002707	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416002708	active site
86416002709	DNA binding site [nucleotide binding]
86416002710	Int/Topo IB signature motif; other site
86416002711	Predicted transcriptional regulator [Transcription]; Region: COG1959
86416002712	Transcriptional regulator; Region: Rrf2; pfam02082
86416002713	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416002714	active site 1 [active]
86416002715	dimer interface [polypeptide binding]; other site
86416002716	hexamer interface [polypeptide binding]; other site
86416002717	active site 2 [active]
86416002718	active site 1 [active]
86416002719	dimer interface [polypeptide binding]; other site
86416002720	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416002721	hexamer interface [polypeptide binding]; other site
86416002722	active site 2 [active]
86416002723	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
86416002724	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
86416002725	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416002726	hexamer interface [polypeptide binding]; other site
86416002727	active site 2 [active]
86416002728	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
86416002729	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416002730	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
86416002731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416002732	Coenzyme A binding pocket [chemical binding]; other site
86416002733	Transposase IS200 like; Region: Y1_Tnp; pfam01797
86416002734	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
86416002735	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
86416002736	Probable transposase; Region: OrfB_IS605; pfam01385
86416002737	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
86416002738	Winged helix-turn helix; Region: HTH_29; pfam13551
86416002739	Homeodomain-like domain; Region: HTH_32; pfam13565
86416002740	Winged helix-turn helix; Region: HTH_33; pfam13592
86416002741	DDE superfamily endonuclease; Region: DDE_3; pfam13358
86416002742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
86416002743	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
86416002744	ApbE family; Region: ApbE; pfam02424
86416002745	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416002746	Pirin-related protein [General function prediction only]; Region: COG1741
86416002747	Pirin; Region: Pirin; pfam02678
86416002748	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416002749	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
86416002750	DNA binding residues [nucleotide binding]
86416002751	putative dimer interface [polypeptide binding]; other site
86416002752	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
86416002753	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
86416002754	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416002755	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416002756	Walker A/P-loop; other site
86416002757	ATP binding site [chemical binding]; other site
86416002758	Q-loop/lid; other site
86416002759	ABC transporter signature motif; other site
86416002760	Walker B; other site
86416002761	D-loop; other site
86416002762	H-loop/switch region; other site
86416002763	EamA-like transporter family; Region: EamA; cl17759
86416002764	EamA-like transporter family; Region: EamA; pfam00892
86416002765	DinB superfamily; Region: DinB_2; pfam12867
86416002766	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
86416002767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416002768	Coenzyme A binding pocket [chemical binding]; other site
86416002769	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416002770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416002771	S-adenosylmethionine binding site [chemical binding]; other site
86416002772	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416002773	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416002774	Isochorismatase family; Region: Isochorismatase; pfam00857
86416002775	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
86416002776	catalytic triad [active]
86416002777	conserved cis-peptide bond; other site
86416002778	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416002779	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
86416002780	active site
86416002781	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
86416002782	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
86416002783	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
86416002784	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
86416002785	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
86416002786	active site
86416002787	catalytic residues [active]
86416002788	metal binding site [ion binding]; metal-binding site
86416002789	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
86416002790	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
86416002791	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416002792	active site
86416002793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416002794	Coenzyme A binding pocket [chemical binding]; other site
86416002795	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416002796	non-specific DNA binding site [nucleotide binding]; other site
86416002797	salt bridge; other site
86416002798	sequence-specific DNA binding site [nucleotide binding]; other site
86416002799	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
86416002800	active site
86416002801	catalytic residues [active]
86416002802	metal binding site [ion binding]; metal-binding site
86416002803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
86416002804	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
86416002805	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
86416002806	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
86416002807	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
86416002808	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
86416002809	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
86416002810	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
86416002811	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
86416002812	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
86416002813	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
86416002814	active site
86416002815	catalytic motif [active]
86416002816	Zn binding site [ion binding]; other site
86416002817	Uncharacterized conserved protein [Function unknown]; Region: COG1359
86416002818	Winged helix-turn helix; Region: HTH_29; pfam13551
86416002819	Homeodomain-like domain; Region: HTH_32; pfam13565
86416002820	Winged helix-turn helix; Region: HTH_33; pfam13592
86416002821	DDE superfamily endonuclease; Region: DDE_3; pfam13358
86416002822	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
86416002823	FtsH Extracellular; Region: FtsH_ext; pfam06480
86416002824	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
86416002825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416002826	Walker A motif; other site
86416002827	ATP binding site [chemical binding]; other site
86416002828	Walker B motif; other site
86416002829	arginine finger; other site
86416002830	Peptidase family M41; Region: Peptidase_M41; pfam01434
86416002831	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
86416002832	Part of AAA domain; Region: AAA_19; pfam13245
86416002833	Family description; Region: UvrD_C_2; pfam13538
86416002834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002835	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416002836	putative substrate translocation pore; other site
86416002837	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
86416002838	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
86416002839	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
86416002840	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
86416002841	[2Fe-2S] cluster binding site [ion binding]; other site
86416002842	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
86416002843	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
86416002844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002845	H+ Antiporter protein; Region: 2A0121; TIGR00900
86416002846	putative substrate translocation pore; other site
86416002847	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416002848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416002849	Coenzyme A binding pocket [chemical binding]; other site
86416002850	Isochorismatase family; Region: Isochorismatase; pfam00857
86416002851	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
86416002852	catalytic triad [active]
86416002853	conserved cis-peptide bond; other site
86416002854	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
86416002855	Putative amidase domain; Region: Amidase_6; pfam12671
86416002856	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
86416002857	active site
86416002858	P-loop; other site
86416002859	phosphorylation site [posttranslational modification]
86416002860	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
86416002861	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
86416002862	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
86416002863	methionine cluster; other site
86416002864	active site
86416002865	phosphorylation site [posttranslational modification]
86416002866	metal binding site [ion binding]; metal-binding site
86416002867	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416002868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416002869	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416002870	dimerization interface [polypeptide binding]; other site
86416002871	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416002872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416002873	dimer interface [polypeptide binding]; other site
86416002874	conserved gate region; other site
86416002875	putative PBP binding loops; other site
86416002876	ABC-ATPase subunit interface; other site
86416002877	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416002878	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416002879	Walker A/P-loop; other site
86416002880	ATP binding site [chemical binding]; other site
86416002881	Q-loop/lid; other site
86416002882	ABC transporter signature motif; other site
86416002883	Walker B; other site
86416002884	D-loop; other site
86416002885	H-loop/switch region; other site
86416002886	threonine synthase; Validated; Region: PRK08197
86416002887	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
86416002888	homodimer interface [polypeptide binding]; other site
86416002889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416002890	catalytic residue [active]
86416002891	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416002892	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416002893	substrate binding pocket [chemical binding]; other site
86416002894	membrane-bound complex binding site; other site
86416002895	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
86416002896	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
86416002897	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
86416002898	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416002899	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416002900	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
86416002901	EamA-like transporter family; Region: EamA; pfam00892
86416002902	EamA-like transporter family; Region: EamA; pfam00892
86416002903	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
86416002904	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416002905	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416002906	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416002907	active site
86416002908	catalytic tetrad [active]
86416002909	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416002910	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
86416002911	active site
86416002912	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
86416002913	active site
86416002914	catalytic residues [active]
86416002915	metal binding site [ion binding]; metal-binding site
86416002916	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
86416002917	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416002918	motif II; other site
86416002919	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
86416002920	Predicted membrane protein [Function unknown]; Region: COG2323
86416002921	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
86416002922	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
86416002923	stage V sporulation protein AD; Provisional; Region: PRK12404
86416002924	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
86416002925	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
86416002926	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
86416002927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
86416002928	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416002929	EamA-like transporter family; Region: EamA; pfam00892
86416002930	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
86416002931	EamA-like transporter family; Region: EamA; pfam00892
86416002932	Predicted transcriptional regulator [Transcription]; Region: COG1959
86416002933	Transcriptional regulator; Region: Rrf2; pfam02082
86416002934	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
86416002935	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
86416002936	active site
86416002937	FMN binding site [chemical binding]; other site
86416002938	substrate binding site [chemical binding]; other site
86416002939	putative catalytic residue [active]
86416002940	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
86416002941	putative FMN binding site [chemical binding]; other site
86416002942	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416002943	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
86416002944	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416002945	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416002946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416002947	motif II; other site
86416002948	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416002949	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
86416002950	active site
86416002951	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
86416002952	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
86416002953	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
86416002954	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
86416002955	active site
86416002956	metal binding site [ion binding]; metal-binding site
86416002957	aspartate kinase; Reviewed; Region: PRK06635
86416002958	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
86416002959	putative nucleotide binding site [chemical binding]; other site
86416002960	putative catalytic residues [active]
86416002961	putative Mg ion binding site [ion binding]; other site
86416002962	putative aspartate binding site [chemical binding]; other site
86416002963	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
86416002964	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
86416002965	diaminopimelate decarboxylase; Region: lysA; TIGR01048
86416002966	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
86416002967	active site
86416002968	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
86416002969	substrate binding site [chemical binding]; other site
86416002970	catalytic residues [active]
86416002971	dimer interface [polypeptide binding]; other site
86416002972	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
86416002973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416002974	NAD(P) binding site [chemical binding]; other site
86416002975	active site
86416002976	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416002977	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416002978	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416002979	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
86416002980	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416002981	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
86416002982	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
86416002983	active site
86416002984	motif I; other site
86416002985	motif II; other site
86416002986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416002987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416002988	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416002989	putative substrate translocation pore; other site
86416002990	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
86416002991	Putative glucoamylase; Region: Glycoamylase; pfam10091
86416002992	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
86416002993	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
86416002994	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
86416002995	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
86416002996	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
86416002997	non-heme iron binding site [ion binding]; other site
86416002998	dimer interface [polypeptide binding]; other site
86416002999	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
86416003000	non-heme iron binding site [ion binding]; other site
86416003001	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
86416003002	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
86416003003	active site
86416003004	HIGH motif; other site
86416003005	dimer interface [polypeptide binding]; other site
86416003006	KMSKS motif; other site
86416003007	PAS fold; Region: PAS; pfam00989
86416003008	PAS domain; Region: PAS_8; pfam13188
86416003009	putative active site [active]
86416003010	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
86416003011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
86416003012	dimer interface [polypeptide binding]; other site
86416003013	phosphorylation site [posttranslational modification]
86416003014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003015	ATP binding site [chemical binding]; other site
86416003016	Mg2+ binding site [ion binding]; other site
86416003017	G-X-G motif; other site
86416003018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416003019	PAS domain; Region: PAS_9; pfam13426
86416003020	putative active site [active]
86416003021	heme pocket [chemical binding]; other site
86416003022	PAS domain S-box; Region: sensory_box; TIGR00229
86416003023	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
86416003024	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
86416003025	metal binding site [ion binding]; metal-binding site
86416003026	active site
86416003027	I-site; other site
86416003028	sugar phosphate phosphatase; Provisional; Region: PRK10513
86416003029	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416003030	active site
86416003031	motif I; other site
86416003032	motif II; other site
86416003033	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416003034	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
86416003035	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
86416003036	G1 box; other site
86416003037	putative GEF interaction site [polypeptide binding]; other site
86416003038	GTP/Mg2+ binding site [chemical binding]; other site
86416003039	Switch I region; other site
86416003040	G2 box; other site
86416003041	G3 box; other site
86416003042	Switch II region; other site
86416003043	G4 box; other site
86416003044	G5 box; other site
86416003045	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
86416003046	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
86416003047	dimer interface [polypeptide binding]; other site
86416003048	active site
86416003049	Schiff base residues; other site
86416003050	Iron permease FTR1 family; Region: FTR1; cl00475
86416003051	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
86416003052	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
86416003053	active site
86416003054	C-terminal domain interface [polypeptide binding]; other site
86416003055	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
86416003056	active site
86416003057	N-terminal domain interface [polypeptide binding]; other site
86416003058	cobyric acid synthase; Provisional; Region: PRK00784
86416003059	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416003060	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416003061	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
86416003062	catalytic triad [active]
86416003063	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
86416003064	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
86416003065	putative dimer interface [polypeptide binding]; other site
86416003066	catalytic triad [active]
86416003067	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
86416003068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416003069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003070	homodimer interface [polypeptide binding]; other site
86416003071	catalytic residue [active]
86416003072	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
86416003073	homodimer interface [polypeptide binding]; other site
86416003074	Walker A motif; other site
86416003075	ATP binding site [chemical binding]; other site
86416003076	hydroxycobalamin binding site [chemical binding]; other site
86416003077	Walker B motif; other site
86416003078	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
86416003079	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
86416003080	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
86416003081	catalytic triad [active]
86416003082	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416003083	Coenzyme A binding pocket [chemical binding]; other site
86416003084	precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575
86416003085	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
86416003086	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
86416003087	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
86416003088	active site
86416003089	putative homodimer interface [polypeptide binding]; other site
86416003090	SAM binding site [chemical binding]; other site
86416003091	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
86416003092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416003093	S-adenosylmethionine binding site [chemical binding]; other site
86416003094	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
86416003095	active site
86416003096	SAM binding site [chemical binding]; other site
86416003097	homodimer interface [polypeptide binding]; other site
86416003098	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
86416003099	active site
86416003100	SAM binding site [chemical binding]; other site
86416003101	homodimer interface [polypeptide binding]; other site
86416003102	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
86416003103	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
86416003104	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
86416003105	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
86416003106	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
86416003107	active site
86416003108	SAM binding site [chemical binding]; other site
86416003109	homodimer interface [polypeptide binding]; other site
86416003110	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
86416003111	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
86416003112	hypothetical protein; Provisional; Region: PRK02237
86416003113	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
86416003114	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
86416003115	mevalonate kinase; Region: mevalon_kin; TIGR00549
86416003116	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
86416003117	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
86416003118	Probable zinc-binding domain; Region: zf-trcl; pfam13451
86416003119	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
86416003120	GAF domain; Region: GAF_3; pfam13492
86416003121	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
86416003122	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
86416003123	metal binding site [ion binding]; metal-binding site
86416003124	active site
86416003125	I-site; other site
86416003126	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
86416003127	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
86416003128	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
86416003129	active site
86416003130	HIGH motif; other site
86416003131	dimer interface [polypeptide binding]; other site
86416003132	KMSKS motif; other site
86416003133	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416003134	RNA binding surface [nucleotide binding]; other site
86416003135	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
86416003136	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
86416003137	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416003138	putative active site [active]
86416003139	putative metal binding site [ion binding]; other site
86416003140	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
86416003141	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
86416003142	dimer interface [polypeptide binding]; other site
86416003143	putative CheW interface [polypeptide binding]; other site
86416003144	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
86416003145	synthetase active site [active]
86416003146	NTP binding site [chemical binding]; other site
86416003147	metal binding site [ion binding]; metal-binding site
86416003148	Spore germination protein; Region: Spore_permease; cl17796
86416003149	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
86416003150	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
86416003151	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
86416003152	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416003153	MULE transposase domain; Region: MULE; pfam10551
86416003154	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
86416003155	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
86416003156	HIGH motif; other site
86416003157	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
86416003158	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
86416003159	active site
86416003160	KMSKS motif; other site
86416003161	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
86416003162	tRNA binding surface [nucleotide binding]; other site
86416003163	IucA / IucC family; Region: IucA_IucC; pfam04183
86416003164	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
86416003165	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
86416003166	HSP70 interaction site [polypeptide binding]; other site
86416003167	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
86416003168	putative active site; other site
86416003169	putative metal binding residues [ion binding]; other site
86416003170	signature motif; other site
86416003171	putative triphosphate binding site [ion binding]; other site
86416003172	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
86416003173	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
86416003174	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416003175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003176	homodimer interface [polypeptide binding]; other site
86416003177	catalytic residue [active]
86416003178	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
86416003179	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
86416003180	intersubunit interface [polypeptide binding]; other site
86416003181	active site
86416003182	zinc binding site [ion binding]; other site
86416003183	Na+ binding site [ion binding]; other site
86416003184	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
86416003185	Predicted membrane protein [Function unknown]; Region: COG2323
86416003186	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
86416003187	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
86416003188	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
86416003189	putative L-serine binding site [chemical binding]; other site
86416003190	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
86416003191	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
86416003192	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
86416003193	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
86416003194	hypothetical protein; Validated; Region: PRK07668
86416003195	Uncharacterized conserved protein [Function unknown]; Region: COG0398
86416003196	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
86416003197	FOG: CBS domain [General function prediction only]; Region: COG0517
86416003198	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
86416003199	putative lipid kinase; Reviewed; Region: PRK13059
86416003200	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
86416003201	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416003202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003203	active site
86416003204	phosphorylation site [posttranslational modification]
86416003205	intermolecular recognition site; other site
86416003206	dimerization interface [polypeptide binding]; other site
86416003207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416003208	DNA binding site [nucleotide binding]
86416003209	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416003210	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416003211	dimerization interface [polypeptide binding]; other site
86416003212	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416003213	dimer interface [polypeptide binding]; other site
86416003214	phosphorylation site [posttranslational modification]
86416003215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003216	ATP binding site [chemical binding]; other site
86416003217	Mg2+ binding site [ion binding]; other site
86416003218	G-X-G motif; other site
86416003219	4Fe-4S binding domain; Region: Fer4_5; pfam12801
86416003220	4Fe-4S binding domain; Region: Fer4_5; pfam12801
86416003221	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416003222	FMN-binding domain; Region: FMN_bind; cl01081
86416003223	FMN-binding domain; Region: FMN_bind; cl01081
86416003224	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416003225	monogalactosyldiacylglycerol synthase; Region: PLN02605
86416003226	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416003227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416003228	putative substrate translocation pore; other site
86416003229	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
86416003230	active site
86416003231	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
86416003232	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416003233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003234	active site
86416003235	phosphorylation site [posttranslational modification]
86416003236	intermolecular recognition site; other site
86416003237	dimerization interface [polypeptide binding]; other site
86416003238	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416003239	DNA binding site [nucleotide binding]
86416003240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416003241	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416003242	dimerization interface [polypeptide binding]; other site
86416003243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416003244	dimer interface [polypeptide binding]; other site
86416003245	phosphorylation site [posttranslational modification]
86416003246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003247	ATP binding site [chemical binding]; other site
86416003248	Mg2+ binding site [ion binding]; other site
86416003249	G-X-G motif; other site
86416003250	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
86416003251	hypothetical protein; Provisional; Region: PRK00955
86416003252	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
86416003253	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
86416003254	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416003255	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
86416003256	serine O-acetyltransferase; Region: cysE; TIGR01172
86416003257	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
86416003258	trimer interface [polypeptide binding]; other site
86416003259	active site
86416003260	substrate binding site [chemical binding]; other site
86416003261	CoA binding site [chemical binding]; other site
86416003262	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416003263	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
86416003264	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
86416003265	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
86416003266	putative acyl-acceptor binding pocket; other site
86416003267	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
86416003268	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
86416003269	minor groove reading motif; other site
86416003270	helix-hairpin-helix signature motif; other site
86416003271	substrate binding pocket [chemical binding]; other site
86416003272	active site
86416003273	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
86416003274	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
86416003275	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
86416003276	Cl- selectivity filter; other site
86416003277	Cl- binding residues [ion binding]; other site
86416003278	pore gating glutamate residue; other site
86416003279	dimer interface [polypeptide binding]; other site
86416003280	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
86416003281	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
86416003282	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
86416003283	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
86416003284	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416003285	Zn2+ binding site [ion binding]; other site
86416003286	Mg2+ binding site [ion binding]; other site
86416003287	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
86416003288	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416003289	LemA family; Region: LemA; pfam04011
86416003290	Repair protein; Region: Repair_PSII; pfam04536
86416003291	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
86416003292	GAF domain; Region: GAF; pfam01590
86416003293	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416003294	Zn2+ binding site [ion binding]; other site
86416003295	Mg2+ binding site [ion binding]; other site
86416003296	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
86416003297	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
86416003298	putative oligomer interface [polypeptide binding]; other site
86416003299	putative active site [active]
86416003300	metal binding site [ion binding]; metal-binding site
86416003301	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
86416003302	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
86416003303	VanW like protein; Region: VanW; pfam04294
86416003304	G5 domain; Region: G5; pfam07501
86416003305	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416003306	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416003307	active site
86416003308	TDP-binding site; other site
86416003309	acceptor substrate-binding pocket; other site
86416003310	homodimer interface [polypeptide binding]; other site
86416003311	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
86416003312	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416003313	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
86416003314	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
86416003315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416003316	dimer interface [polypeptide binding]; other site
86416003317	conserved gate region; other site
86416003318	putative PBP binding loops; other site
86416003319	ABC-ATPase subunit interface; other site
86416003320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416003321	dimer interface [polypeptide binding]; other site
86416003322	conserved gate region; other site
86416003323	putative PBP binding loops; other site
86416003324	ABC-ATPase subunit interface; other site
86416003325	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
86416003326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416003327	Walker A/P-loop; other site
86416003328	ATP binding site [chemical binding]; other site
86416003329	Q-loop/lid; other site
86416003330	ABC transporter signature motif; other site
86416003331	Walker B; other site
86416003332	D-loop; other site
86416003333	H-loop/switch region; other site
86416003334	TOBE domain; Region: TOBE_2; pfam08402
86416003335	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
86416003336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416003337	Walker A motif; other site
86416003338	ATP binding site [chemical binding]; other site
86416003339	Walker B motif; other site
86416003340	arginine finger; other site
86416003341	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
86416003342	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
86416003343	PYR/PP interface [polypeptide binding]; other site
86416003344	dimer interface [polypeptide binding]; other site
86416003345	TPP binding site [chemical binding]; other site
86416003346	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
86416003347	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
86416003348	TPP-binding site [chemical binding]; other site
86416003349	dimer interface [polypeptide binding]; other site
86416003350	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
86416003351	putative valine binding site [chemical binding]; other site
86416003352	dimer interface [polypeptide binding]; other site
86416003353	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
86416003354	Ligand Binding Site [chemical binding]; other site
86416003355	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
86416003356	dimer interface [polypeptide binding]; other site
86416003357	FMN binding site [chemical binding]; other site
86416003358	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
86416003359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416003360	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416003361	putative substrate translocation pore; other site
86416003362	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
86416003363	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
86416003364	acyl-activating enzyme (AAE) consensus motif; other site
86416003365	AMP binding site [chemical binding]; other site
86416003366	active site
86416003367	CoA binding site [chemical binding]; other site
86416003368	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
86416003369	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
86416003370	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
86416003371	active site
86416003372	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
86416003373	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
86416003374	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
86416003375	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
86416003376	putative NADP binding site [chemical binding]; other site
86416003377	active site
86416003378	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
86416003379	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
86416003380	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
86416003381	active site
86416003382	acyl-CoA synthetase; Validated; Region: PRK09192
86416003383	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
86416003384	acyl-activating enzyme (AAE) consensus motif; other site
86416003385	AMP binding site [chemical binding]; other site
86416003386	active site
86416003387	CoA binding site [chemical binding]; other site
86416003388	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
86416003389	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
86416003390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416003391	dimerization interface [polypeptide binding]; other site
86416003392	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416003393	dimer interface [polypeptide binding]; other site
86416003394	phosphorylation site [posttranslational modification]
86416003395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003396	ATP binding site [chemical binding]; other site
86416003397	Mg2+ binding site [ion binding]; other site
86416003398	G-X-G motif; other site
86416003399	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416003400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003401	active site
86416003402	phosphorylation site [posttranslational modification]
86416003403	intermolecular recognition site; other site
86416003404	dimerization interface [polypeptide binding]; other site
86416003405	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416003406	DNA binding site [nucleotide binding]
86416003407	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
86416003408	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
86416003409	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
86416003410	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
86416003411	Histidine kinase; Region: HisKA_3; pfam07730
86416003412	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
86416003413	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
86416003414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003415	active site
86416003416	phosphorylation site [posttranslational modification]
86416003417	intermolecular recognition site; other site
86416003418	dimerization interface [polypeptide binding]; other site
86416003419	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
86416003420	DNA binding residues [nucleotide binding]
86416003421	dimerization interface [polypeptide binding]; other site
86416003422	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416003423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416003424	Walker A/P-loop; other site
86416003425	ATP binding site [chemical binding]; other site
86416003426	Q-loop/lid; other site
86416003427	ABC transporter signature motif; other site
86416003428	Walker B; other site
86416003429	D-loop; other site
86416003430	H-loop/switch region; other site
86416003431	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
86416003432	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416003433	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
86416003434	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
86416003435	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416003436	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
86416003437	catalytic core [active]
86416003438	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
86416003439	DNA polymerase IV; Reviewed; Region: PRK03103
86416003440	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
86416003441	active site
86416003442	DNA binding site [nucleotide binding]
86416003443	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
86416003444	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
86416003445	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
86416003446	putative active site [active]
86416003447	catalytic site [active]
86416003448	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
86416003449	putative active site [active]
86416003450	catalytic site [active]
86416003451	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
86416003452	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
86416003453	ligand binding site [chemical binding]; other site
86416003454	flexible hinge region; other site
86416003455	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
86416003456	Ferredoxin [Energy production and conversion]; Region: COG1146
86416003457	4Fe-4S binding domain; Region: Fer4_6; pfam12837
86416003458	Uncharacterized conserved protein [Function unknown]; Region: COG1434
86416003459	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
86416003460	putative active site [active]
86416003461	ent-kaur-16-ene synthase; Region: PLN02279
86416003462	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
86416003463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416003464	motif II; other site
86416003465	Protein of unknown function (DUF503); Region: DUF503; pfam04456
86416003466	6-phosphofructokinase; Provisional; Region: PRK03202
86416003467	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
86416003468	active site
86416003469	ADP/pyrophosphate binding site [chemical binding]; other site
86416003470	dimerization interface [polypeptide binding]; other site
86416003471	allosteric effector site; other site
86416003472	fructose-1,6-bisphosphate binding site; other site
86416003473	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
86416003474	classical (c) SDRs; Region: SDR_c; cd05233
86416003475	NAD(P) binding site [chemical binding]; other site
86416003476	active site
86416003477	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
86416003478	active pocket/dimerization site; other site
86416003479	active site
86416003480	phosphorylation site [posttranslational modification]
86416003481	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
86416003482	active site
86416003483	phosphorylation site [posttranslational modification]
86416003484	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
86416003485	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
86416003486	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
86416003487	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416003488	putative NAD(P) binding site [chemical binding]; other site
86416003489	catalytic Zn binding site [ion binding]; other site
86416003490	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416003491	MULE transposase domain; Region: MULE; pfam10551
86416003492	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
86416003493	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
86416003494	putative catalytic cysteine [active]
86416003495	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
86416003496	putative active site [active]
86416003497	metal binding site [ion binding]; metal-binding site
86416003498	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
86416003499	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
86416003500	glutaminase active site [active]
86416003501	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
86416003502	dimer interface [polypeptide binding]; other site
86416003503	active site
86416003504	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
86416003505	dimer interface [polypeptide binding]; other site
86416003506	active site
86416003507	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
86416003508	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
86416003509	Uncharacterized conserved protein [Function unknown]; Region: COG0397
86416003510	hypothetical protein; Validated; Region: PRK00029
86416003511	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
86416003512	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
86416003513	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416003514	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
86416003515	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
86416003516	GatB domain; Region: GatB_Yqey; smart00845
86416003517	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
86416003518	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
86416003519	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
86416003520	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416003521	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416003522	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416003523	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
86416003524	DNA binding residues [nucleotide binding]
86416003525	dimer interface [polypeptide binding]; other site
86416003526	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
86416003527	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416003528	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416003529	Walker A/P-loop; other site
86416003530	ATP binding site [chemical binding]; other site
86416003531	Q-loop/lid; other site
86416003532	ABC transporter signature motif; other site
86416003533	Walker B; other site
86416003534	D-loop; other site
86416003535	H-loop/switch region; other site
86416003536	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416003537	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
86416003538	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416003539	Coenzyme A binding pocket [chemical binding]; other site
86416003540	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
86416003541	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416003542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416003543	DNA binding residues [nucleotide binding]
86416003544	hypothetical protein; Provisional; Region: PTZ00207
86416003545	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
86416003546	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416003547	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416003548	Walker A/P-loop; other site
86416003549	ATP binding site [chemical binding]; other site
86416003550	Q-loop/lid; other site
86416003551	ABC transporter signature motif; other site
86416003552	Walker B; other site
86416003553	D-loop; other site
86416003554	H-loop/switch region; other site
86416003555	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416003556	MarR family; Region: MarR_2; cl17246
86416003557	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416003558	MarR family; Region: MarR_2; pfam12802
86416003559	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
86416003560	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
86416003561	substrate binding pocket [chemical binding]; other site
86416003562	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416003563	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416003564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416003565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416003566	dimerization interface [polypeptide binding]; other site
86416003567	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
86416003568	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
86416003569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003570	ATP binding site [chemical binding]; other site
86416003571	Mg2+ binding site [ion binding]; other site
86416003572	G-X-G motif; other site
86416003573	Response regulator receiver domain; Region: Response_reg; pfam00072
86416003574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003575	phosphorylation site [posttranslational modification]
86416003576	intermolecular recognition site; other site
86416003577	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416003578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416003579	non-specific DNA binding site [nucleotide binding]; other site
86416003580	salt bridge; other site
86416003581	sequence-specific DNA binding site [nucleotide binding]; other site
86416003582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416003583	non-specific DNA binding site [nucleotide binding]; other site
86416003584	salt bridge; other site
86416003585	sequence-specific DNA binding site [nucleotide binding]; other site
86416003586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416003587	non-specific DNA binding site [nucleotide binding]; other site
86416003588	salt bridge; other site
86416003589	sequence-specific DNA binding site [nucleotide binding]; other site
86416003590	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
86416003591	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
86416003592	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416003593	DNA-binding site [nucleotide binding]; DNA binding site
86416003594	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416003595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003596	homodimer interface [polypeptide binding]; other site
86416003597	catalytic residue [active]
86416003598	Chromate transporter; Region: Chromate_transp; pfam02417
86416003599	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
86416003600	Chromate transporter; Region: Chromate_transp; pfam02417
86416003601	This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078
86416003602	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
86416003603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416003604	DNA-binding site [nucleotide binding]; DNA binding site
86416003605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416003606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003607	homodimer interface [polypeptide binding]; other site
86416003608	catalytic residue [active]
86416003609	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
86416003610	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
86416003611	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
86416003612	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
86416003613	active site
86416003614	P-loop; other site
86416003615	phosphorylation site [posttranslational modification]
86416003616	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
86416003617	active site
86416003618	P-loop; other site
86416003619	phosphorylation site [posttranslational modification]
86416003620	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
86416003621	Mga helix-turn-helix domain; Region: Mga; pfam05043
86416003622	PRD domain; Region: PRD; pfam00874
86416003623	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
86416003624	active site
86416003625	P-loop; other site
86416003626	phosphorylation site [posttranslational modification]
86416003627	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
86416003628	active site
86416003629	phosphorylation site [posttranslational modification]
86416003630	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416003631	active site
86416003632	phosphorylation site [posttranslational modification]
86416003633	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
86416003634	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
86416003635	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
86416003636	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
86416003637	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
86416003638	putative catalytic cysteine [active]
86416003639	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
86416003640	putative active site [active]
86416003641	metal binding site [ion binding]; metal-binding site
86416003642	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
86416003643	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
86416003644	active site
86416003645	dimer interface [polypeptide binding]; other site
86416003646	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
86416003647	dimer interface [polypeptide binding]; other site
86416003648	active site
86416003649	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
86416003650	classical (c) SDRs; Region: SDR_c; cd05233
86416003651	NAD(P) binding site [chemical binding]; other site
86416003652	active site
86416003653	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
86416003654	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
86416003655	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
86416003656	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
86416003657	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
86416003658	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
86416003659	MutS domain III; Region: MutS_III; pfam05192
86416003660	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
86416003661	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
86416003662	Walker A/P-loop; other site
86416003663	ATP binding site [chemical binding]; other site
86416003664	Q-loop/lid; other site
86416003665	ABC transporter signature motif; other site
86416003666	Walker B; other site
86416003667	D-loop; other site
86416003668	H-loop/switch region; other site
86416003669	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
86416003670	Nuclease-related domain; Region: NERD; pfam08378
86416003671	UGMP family protein; Validated; Region: PRK09604
86416003672	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
86416003673	Uncharacterized conserved protein [Function unknown]; Region: COG1284
86416003674	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
86416003675	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
86416003676	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416003677	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416003678	dimer interface [polypeptide binding]; other site
86416003679	ssDNA binding site [nucleotide binding]; other site
86416003680	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416003681	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
86416003682	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
86416003683	Histidine kinase; Region: His_kinase; pfam06580
86416003684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003685	ATP binding site [chemical binding]; other site
86416003686	Mg2+ binding site [ion binding]; other site
86416003687	G-X-G motif; other site
86416003688	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
86416003689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003690	active site
86416003691	phosphorylation site [posttranslational modification]
86416003692	intermolecular recognition site; other site
86416003693	dimerization interface [polypeptide binding]; other site
86416003694	LytTr DNA-binding domain; Region: LytTR; pfam04397
86416003695	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
86416003696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416003697	Walker A/P-loop; other site
86416003698	ATP binding site [chemical binding]; other site
86416003699	Q-loop/lid; other site
86416003700	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416003701	ABC transporter; Region: ABC_tran_2; pfam12848
86416003702	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416003703	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
86416003704	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
86416003705	CoA binding domain; Region: CoA_binding; pfam02629
86416003706	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
86416003707	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
86416003708	substrate binding site [chemical binding]; other site
86416003709	oxyanion hole (OAH) forming residues; other site
86416003710	trimer interface [polypeptide binding]; other site
86416003711	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
86416003712	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
86416003713	FAD binding site [chemical binding]; other site
86416003714	homotetramer interface [polypeptide binding]; other site
86416003715	substrate binding pocket [chemical binding]; other site
86416003716	catalytic base [active]
86416003717	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
86416003718	Ligand binding site [chemical binding]; other site
86416003719	Electron transfer flavoprotein domain; Region: ETF; pfam01012
86416003720	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
86416003721	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
86416003722	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
86416003723	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
86416003724	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
86416003725	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
86416003726	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
86416003727	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
86416003728	FAD binding pocket [chemical binding]; other site
86416003729	FAD binding motif [chemical binding]; other site
86416003730	phosphate binding motif [ion binding]; other site
86416003731	beta-alpha-beta structure motif; other site
86416003732	NAD binding pocket [chemical binding]; other site
86416003733	Iron coordination center [ion binding]; other site
86416003734	putative oxidoreductase; Provisional; Region: PRK12831
86416003735	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
86416003736	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416003737	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
86416003738	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
86416003739	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
86416003740	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
86416003741	minor groove reading motif; other site
86416003742	helix-hairpin-helix signature motif; other site
86416003743	substrate binding pocket [chemical binding]; other site
86416003744	active site
86416003745	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
86416003746	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
86416003747	oligomerisation interface [polypeptide binding]; other site
86416003748	mobile loop; other site
86416003749	roof hairpin; other site
86416003750	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
86416003751	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
86416003752	ring oligomerisation interface [polypeptide binding]; other site
86416003753	ATP/Mg binding site [chemical binding]; other site
86416003754	stacking interactions; other site
86416003755	hinge regions; other site
86416003756	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
86416003757	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416003758	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
86416003759	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
86416003760	active site
86416003761	GMP synthase; Reviewed; Region: guaA; PRK00074
86416003762	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
86416003763	AMP/PPi binding site [chemical binding]; other site
86416003764	candidate oxyanion hole; other site
86416003765	catalytic triad [active]
86416003766	potential glutamine specificity residues [chemical binding]; other site
86416003767	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
86416003768	ATP Binding subdomain [chemical binding]; other site
86416003769	Ligand Binding sites [chemical binding]; other site
86416003770	Dimerization subdomain; other site
86416003771	TM2 domain; Region: TM2; pfam05154
86416003772	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
86416003773	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
86416003774	hypothetical protein; Validated; Region: PRK00124
86416003775	pullulanase, type I; Region: pulA_typeI; TIGR02104
86416003776	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
86416003777	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
86416003778	Ca binding site [ion binding]; other site
86416003779	active site
86416003780	catalytic site [active]
86416003781	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
86416003782	triple tyrosine motif-containing protein; Provisional; Region: PRK14081
86416003783	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
86416003784	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
86416003785	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
86416003786	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
86416003787	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
86416003788	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
86416003789	N-acetyl-D-glucosamine binding site [chemical binding]; other site
86416003790	catalytic residue [active]
86416003791	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
86416003792	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416003793	RNA binding surface [nucleotide binding]; other site
86416003794	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
86416003795	active site
86416003796	uracil binding [chemical binding]; other site
86416003797	Trp repressor protein; Region: Trp_repressor; cl17266
86416003798	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
86416003799	Part of AAA domain; Region: AAA_19; pfam13245
86416003800	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
86416003801	protein-splicing catalytic site; other site
86416003802	thioester formation/cholesterol transfer; other site
86416003803	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
86416003804	protein-splicing catalytic site; other site
86416003805	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
86416003806	Family description; Region: UvrD_C_2; pfam13538
86416003807	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
86416003808	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
86416003809	nucleotide binding pocket [chemical binding]; other site
86416003810	K-X-D-G motif; other site
86416003811	catalytic site [active]
86416003812	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
86416003813	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
86416003814	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
86416003815	Dimer interface [polypeptide binding]; other site
86416003816	BRCT sequence motif; other site
86416003817	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
86416003818	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
86416003819	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
86416003820	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
86416003821	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
86416003822	GatB domain; Region: GatB_Yqey; smart00845
86416003823	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
86416003824	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
86416003825	peptide binding site [polypeptide binding]; other site
86416003826	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
86416003827	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
86416003828	dimerization interface [polypeptide binding]; other site
86416003829	putative ATP binding site [chemical binding]; other site
86416003830	ribonuclease PH; Reviewed; Region: rph; PRK00173
86416003831	Ribonuclease PH; Region: RNase_PH_bact; cd11362
86416003832	hexamer interface [polypeptide binding]; other site
86416003833	active site
86416003834	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
86416003835	active site
86416003836	dimerization interface [polypeptide binding]; other site
86416003837	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
86416003838	active site
86416003839	metal binding site [ion binding]; metal-binding site
86416003840	homotetramer interface [polypeptide binding]; other site
86416003841	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
86416003842	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
86416003843	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
86416003844	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416003845	Walker A motif; other site
86416003846	ATP binding site [chemical binding]; other site
86416003847	Walker B motif; other site
86416003848	arginine finger; other site
86416003849	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
86416003850	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
86416003851	4Fe-4S binding domain; Region: Fer4; pfam00037
86416003852	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
86416003853	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
86416003854	ACS interaction site; other site
86416003855	CODH interaction site; other site
86416003856	cubane metal cluster (B-cluster) [ion binding]; other site
86416003857	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
86416003858	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
86416003859	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
86416003860	P-loop; other site
86416003861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416003862	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
86416003863	4Fe-4S binding domain; Region: Fer4; pfam00037
86416003864	4Fe-4S binding domain; Region: Fer4; pfam00037
86416003865	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
86416003866	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
86416003867	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
86416003868	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416003869	FeS/SAM binding site; other site
86416003870	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416003871	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416003872	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416003873	dimerization interface [polypeptide binding]; other site
86416003874	putative DNA binding site [nucleotide binding]; other site
86416003875	putative Zn2+ binding site [ion binding]; other site
86416003876	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
86416003877	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416003878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416003879	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416003880	putative substrate translocation pore; other site
86416003881	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416003882	non-specific DNA binding site [nucleotide binding]; other site
86416003883	salt bridge; other site
86416003884	sequence-specific DNA binding site [nucleotide binding]; other site
86416003885	Transcriptional regulators [Transcription]; Region: MarR; COG1846
86416003886	MarR family; Region: MarR_2; cl17246
86416003887	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
86416003888	active site residue [active]
86416003889	Sugar fermentation stimulation protein; Region: SfsA; cl00647
86416003890	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416003891	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
86416003892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416003893	S-adenosylmethionine binding site [chemical binding]; other site
86416003894	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
86416003895	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
86416003896	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
86416003897	substrate-cofactor binding pocket; other site
86416003898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003899	catalytic residue [active]
86416003900	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
86416003901	nudix motif; other site
86416003902	YmaF family; Region: YmaF; pfam12788
86416003903	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
86416003904	AAA domain; Region: AAA_26; pfam13500
86416003905	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
86416003906	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
86416003907	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
86416003908	inhibitor-cofactor binding pocket; inhibition site
86416003909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416003910	catalytic residue [active]
86416003911	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416003912	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
86416003913	putative active site [active]
86416003914	metal binding site [ion binding]; metal-binding site
86416003915	Uncharacterized conserved protein [Function unknown]; Region: COG3287
86416003916	FIST N domain; Region: FIST; pfam08495
86416003917	FIST C domain; Region: FIST_C; pfam10442
86416003918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416003919	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416003920	dimer interface [polypeptide binding]; other site
86416003921	phosphorylation site [posttranslational modification]
86416003922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003923	ATP binding site [chemical binding]; other site
86416003924	Mg2+ binding site [ion binding]; other site
86416003925	G-X-G motif; other site
86416003926	amino acid transporter; Region: 2A0306; TIGR00909
86416003927	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
86416003928	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
86416003929	NAD(P) binding site [chemical binding]; other site
86416003930	homotetramer interface [polypeptide binding]; other site
86416003931	homodimer interface [polypeptide binding]; other site
86416003932	active site
86416003933	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416003934	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
86416003935	Coenzyme A binding pocket [chemical binding]; other site
86416003936	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
86416003937	nudix motif; other site
86416003938	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
86416003939	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416003940	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416003941	non-specific DNA binding site [nucleotide binding]; other site
86416003942	salt bridge; other site
86416003943	sequence-specific DNA binding site [nucleotide binding]; other site
86416003944	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416003945	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416003946	putative active site [active]
86416003947	putative NTP binding site [chemical binding]; other site
86416003948	putative nucleic acid binding site [nucleotide binding]; other site
86416003949	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416003950	Cupin domain; Region: Cupin_2; cl17218
86416003951	anthranilate synthase; Provisional; Region: PRK13566
86416003952	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
86416003953	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
86416003954	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
86416003955	glutamine binding [chemical binding]; other site
86416003956	catalytic triad [active]
86416003957	Chorismate mutase type II; Region: CM_2; cl00693
86416003958	YbaK / prolyl-tRNA synthetases associated domain; Region: YbaK; pfam04073
86416003959	putative deacylase active site [active]
86416003960	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
86416003961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416003962	putative substrate translocation pore; other site
86416003963	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416003964	MarR family; Region: MarR_2; pfam12802
86416003965	MarR family; Region: MarR_2; cl17246
86416003966	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
86416003967	Transglycosylase; Region: Transgly; pfam00912
86416003968	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
86416003969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416003970	Walker A/P-loop; other site
86416003971	ATP binding site [chemical binding]; other site
86416003972	Q-loop/lid; other site
86416003973	ABC transporter signature motif; other site
86416003974	Walker B; other site
86416003975	D-loop; other site
86416003976	H-loop/switch region; other site
86416003977	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416003978	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416003979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416003980	active site
86416003981	phosphorylation site [posttranslational modification]
86416003982	intermolecular recognition site; other site
86416003983	dimerization interface [polypeptide binding]; other site
86416003984	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416003985	DNA binding site [nucleotide binding]
86416003986	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416003987	dimerization interface [polypeptide binding]; other site
86416003988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416003989	dimer interface [polypeptide binding]; other site
86416003990	phosphorylation site [posttranslational modification]
86416003991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416003992	ATP binding site [chemical binding]; other site
86416003993	Mg2+ binding site [ion binding]; other site
86416003994	G-X-G motif; other site
86416003995	multiple promoter invertase; Provisional; Region: mpi; PRK13413
86416003996	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416003997	catalytic residues [active]
86416003998	catalytic nucleophile [active]
86416003999	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416004000	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416004001	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416004002	Synaptic Site I dimer interface [polypeptide binding]; other site
86416004003	DNA binding site [nucleotide binding]
86416004004	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416004005	active site
86416004006	DNA binding site [nucleotide binding]
86416004007	Int/Topo IB signature motif; other site
86416004008	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416004009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416004010	putative DNA binding site [nucleotide binding]; other site
86416004011	putative Zn2+ binding site [ion binding]; other site
86416004012	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
86416004013	Predicted membrane protein [Function unknown]; Region: COG2246
86416004014	GtrA-like protein; Region: GtrA; pfam04138
86416004015	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
86416004016	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416004017	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416004018	MULE transposase domain; Region: MULE; pfam10551
86416004019	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
86416004020	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
86416004021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004022	Coenzyme A binding pocket [chemical binding]; other site
86416004023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416004024	Walker A/P-loop; other site
86416004025	ATP binding site [chemical binding]; other site
86416004026	Q-loop/lid; other site
86416004027	ABC transporter signature motif; other site
86416004028	Walker B; other site
86416004029	D-loop; other site
86416004030	H-loop/switch region; other site
86416004031	DNA polymerase IV; Provisional; Region: PRK14133
86416004032	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
86416004033	active site
86416004034	DNA binding site [nucleotide binding]
86416004035	Predicted membrane protein [Function unknown]; Region: COG4129
86416004036	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
86416004037	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
86416004038	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
86416004039	PQQ-like domain; Region: PQQ_2; pfam13360
86416004040	Uncharacterized conserved protein [Function unknown]; Region: COG3391
86416004041	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
86416004042	Phosphoesterase family; Region: Phosphoesterase; pfam04185
86416004043	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
86416004044	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
86416004045	active site
86416004046	active site
86416004047	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416004048	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416004049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
86416004050	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
86416004051	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416004052	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416004053	NodB motif; other site
86416004054	active site
86416004055	catalytic site [active]
86416004056	Zn binding site [ion binding]; other site
86416004057	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416004058	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
86416004059	putative active site [active]
86416004060	putative metal binding site [ion binding]; other site
86416004061	Putative amidase domain; Region: Amidase_6; pfam12671
86416004062	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
86416004063	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
86416004064	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416004065	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416004066	active site
86416004067	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416004068	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416004069	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416004070	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
86416004071	Uncharacterized conserved protein [Function unknown]; Region: COG2127
86416004072	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
86416004073	Clp amino terminal domain; Region: Clp_N; pfam02861
86416004074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004075	Walker A motif; other site
86416004076	ATP binding site [chemical binding]; other site
86416004077	Walker B motif; other site
86416004078	arginine finger; other site
86416004079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004080	Walker A motif; other site
86416004081	ATP binding site [chemical binding]; other site
86416004082	Walker B motif; other site
86416004083	arginine finger; other site
86416004084	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
86416004085	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416004086	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416004087	DNA binding site [nucleotide binding]
86416004088	domain linker motif; other site
86416004089	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416004090	ligand binding site [chemical binding]; other site
86416004091	dimerization interface [polypeptide binding]; other site
86416004092	Domain of unknown function (DUF386); Region: DUF386; pfam04074
86416004093	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
86416004094	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
86416004095	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
86416004096	mannonate dehydratase; Provisional; Region: PRK03906
86416004097	mannonate dehydratase; Region: uxuA; TIGR00695
86416004098	D-mannonate oxidoreductase; Provisional; Region: PRK08277
86416004099	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
86416004100	putative NAD(P) binding site [chemical binding]; other site
86416004101	active site
86416004102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416004103	D-galactonate transporter; Region: 2A0114; TIGR00893
86416004104	putative substrate translocation pore; other site
86416004105	Domain of unknown function (DUF386); Region: DUF386; cl01047
86416004106	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
86416004107	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
86416004108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416004109	NAD(P) binding site [chemical binding]; other site
86416004110	active site
86416004111	Homoserine O-succinyltransferase; Region: HTS; pfam04204
86416004112	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
86416004113	proposed active site lysine [active]
86416004114	conserved cys residue [active]
86416004115	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
86416004116	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416004117	homodimer interface [polypeptide binding]; other site
86416004118	substrate-cofactor binding pocket; other site
86416004119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416004120	catalytic residue [active]
86416004121	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416004122	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416004123	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416004124	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
86416004125	Walker A/P-loop; other site
86416004126	ATP binding site [chemical binding]; other site
86416004127	Q-loop/lid; other site
86416004128	ABC transporter signature motif; other site
86416004129	Walker B; other site
86416004130	D-loop; other site
86416004131	H-loop/switch region; other site
86416004132	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416004133	active site
86416004134	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
86416004135	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
86416004136	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
86416004137	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
86416004138	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
86416004139	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
86416004140	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
86416004141	dihydroorotase; Validated; Region: pyrC; PRK09357
86416004142	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416004143	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
86416004144	active site
86416004145	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
86416004146	active site
86416004147	dimer interface [polypeptide binding]; other site
86416004148	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
86416004149	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
86416004150	FAD binding pocket [chemical binding]; other site
86416004151	FAD binding motif [chemical binding]; other site
86416004152	phosphate binding motif [ion binding]; other site
86416004153	beta-alpha-beta structure motif; other site
86416004154	NAD binding pocket [chemical binding]; other site
86416004155	Iron coordination center [ion binding]; other site
86416004156	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
86416004157	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
86416004158	heterodimer interface [polypeptide binding]; other site
86416004159	active site
86416004160	FMN binding site [chemical binding]; other site
86416004161	homodimer interface [polypeptide binding]; other site
86416004162	substrate binding site [chemical binding]; other site
86416004163	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416004164	active site
86416004165	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
86416004166	Zn binding site [ion binding]; other site
86416004167	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
86416004168	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
86416004169	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
86416004170	catalytic site [active]
86416004171	subunit interface [polypeptide binding]; other site
86416004172	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
86416004173	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
86416004174	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
86416004175	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
86416004176	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
86416004177	ATP-grasp domain; Region: ATP-grasp_4; cl17255
86416004178	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
86416004179	substrate binding site [chemical binding]; other site
86416004180	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
86416004181	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
86416004182	DNA interaction; other site
86416004183	Metal-binding active site; metal-binding site
86416004184	trigger factor; Provisional; Region: tig; PRK01490
86416004185	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
86416004186	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
86416004187	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
86416004188	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
86416004189	oligomer interface [polypeptide binding]; other site
86416004190	active site residues [active]
86416004191	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
86416004192	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
86416004193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004194	Walker A motif; other site
86416004195	ATP binding site [chemical binding]; other site
86416004196	Walker B motif; other site
86416004197	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
86416004198	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
86416004199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004200	Walker A motif; other site
86416004201	ATP binding site [chemical binding]; other site
86416004202	Walker B motif; other site
86416004203	arginine finger; other site
86416004204	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
86416004205	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
86416004206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004207	Walker A motif; other site
86416004208	ATP binding site [chemical binding]; other site
86416004209	Walker B motif; other site
86416004210	arginine finger; other site
86416004211	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
86416004212	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
86416004213	G1 box; other site
86416004214	GTP/Mg2+ binding site [chemical binding]; other site
86416004215	Switch I region; other site
86416004216	G2 box; other site
86416004217	G3 box; other site
86416004218	Switch II region; other site
86416004219	G4 box; other site
86416004220	G5 box; other site
86416004221	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
86416004222	metal binding site 2 [ion binding]; metal-binding site
86416004223	putative DNA binding helix; other site
86416004224	metal binding site 1 [ion binding]; metal-binding site
86416004225	dimer interface [polypeptide binding]; other site
86416004226	structural Zn2+ binding site [ion binding]; other site
86416004227	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
86416004228	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
86416004229	putative active site [active]
86416004230	PhoH-like protein; Region: PhoH; pfam02562
86416004231	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
86416004232	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
86416004233	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
86416004234	Peptidase family M50; Region: Peptidase_M50; pfam02163
86416004235	active site
86416004236	putative substrate binding region [chemical binding]; other site
86416004237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004238	S-adenosylmethionine binding site [chemical binding]; other site
86416004239	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
86416004240	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
86416004241	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
86416004242	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
86416004243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416004244	NAD(P) binding site [chemical binding]; other site
86416004245	active site
86416004246	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
86416004247	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
86416004248	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
86416004249	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
86416004250	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
86416004251	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416004252	dimer interface [polypeptide binding]; other site
86416004253	active site
86416004254	metal binding site [ion binding]; metal-binding site
86416004255	glutathione binding site [chemical binding]; other site
86416004256	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
86416004257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416004258	NAD(P) binding site [chemical binding]; other site
86416004259	active site
86416004260	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
86416004261	putative ADP-ribose binding site [chemical binding]; other site
86416004262	putative active site [active]
86416004263	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
86416004264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004265	Coenzyme A binding pocket [chemical binding]; other site
86416004266	threonine dehydratase; Provisional; Region: PRK08198
86416004267	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
86416004268	tetramer interface [polypeptide binding]; other site
86416004269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416004270	catalytic residue [active]
86416004271	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
86416004272	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
86416004273	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416004274	homodimer interface [polypeptide binding]; other site
86416004275	substrate-cofactor binding pocket; other site
86416004276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416004277	catalytic residue [active]
86416004278	cystathionine beta-lyase; Provisional; Region: PRK08064
86416004279	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416004280	homodimer interface [polypeptide binding]; other site
86416004281	substrate-cofactor binding pocket; other site
86416004282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416004283	catalytic residue [active]
86416004284	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
86416004285	active site clefts [active]
86416004286	zinc binding site [ion binding]; other site
86416004287	dimer interface [polypeptide binding]; other site
86416004288	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
86416004289	Part of AAA domain; Region: AAA_19; pfam13245
86416004290	Family description; Region: UvrD_C_2; pfam13538
86416004291	TspO/MBR family; Region: TspO_MBR; pfam03073
86416004292	Biotin operon repressor [Transcription]; Region: BirA; COG1654
86416004293	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
86416004294	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
86416004295	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
86416004296	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
86416004297	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
86416004298	NADP binding site [chemical binding]; other site
86416004299	active site
86416004300	putative substrate binding site [chemical binding]; other site
86416004301	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
86416004302	Part of AAA domain; Region: AAA_19; pfam13245
86416004303	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
86416004304	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416004305	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416004306	Arginase family; Region: Arginase; cd09989
86416004307	active site
86416004308	Mn binding site [ion binding]; other site
86416004309	oligomer interface [polypeptide binding]; other site
86416004310	integrase; Provisional; Region: int; PHA02601
86416004311	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416004312	Int/Topo IB signature motif; other site
86416004313	Domain of unknown function (DUF955); Region: DUF955; cl01076
86416004314	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416004315	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004316	non-specific DNA binding site [nucleotide binding]; other site
86416004317	salt bridge; other site
86416004318	sequence-specific DNA binding site [nucleotide binding]; other site
86416004319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004320	non-specific DNA binding site [nucleotide binding]; other site
86416004321	salt bridge; other site
86416004322	sequence-specific DNA binding site [nucleotide binding]; other site
86416004323	Helix-turn-helix domain; Region: HTH_17; cl17695
86416004324	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
86416004325	Mg binding site [ion binding]; other site
86416004326	nucleotide binding site [chemical binding]; other site
86416004327	putative protofilament interface [polypeptide binding]; other site
86416004328	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
86416004329	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
86416004330	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416004331	putative active site [active]
86416004332	putative NTP binding site [chemical binding]; other site
86416004333	putative nucleic acid binding site [nucleotide binding]; other site
86416004334	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416004335	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
86416004336	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
86416004337	N-acetyl-D-glucosamine binding site [chemical binding]; other site
86416004338	catalytic residue [active]
86416004339	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416004340	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416004341	TIGR02588 family protein; Region: TIGR02588
86416004342	Short C-terminal domain; Region: SHOCT; pfam09851
86416004343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004344	S-adenosylmethionine binding site [chemical binding]; other site
86416004345	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
86416004346	AAA-like domain; Region: AAA_10; pfam12846
86416004347	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
86416004348	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
86416004349	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
86416004350	Catalytic site [active]
86416004351	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416004352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004353	non-specific DNA binding site [nucleotide binding]; other site
86416004354	salt bridge; other site
86416004355	sequence-specific DNA binding site [nucleotide binding]; other site
86416004356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
86416004357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004358	Coenzyme A binding pocket [chemical binding]; other site
86416004359	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416004360	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416004361	putative active site [active]
86416004362	putative NTP binding site [chemical binding]; other site
86416004363	putative nucleic acid binding site [nucleotide binding]; other site
86416004364	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416004365	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
86416004366	active site
86416004367	catalytic motif [active]
86416004368	Zn binding site [ion binding]; other site
86416004369	aspartate racemase; Region: asp_race; TIGR00035
86416004370	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416004371	quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906
86416004372	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416004373	FeS/SAM binding site; other site
86416004374	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416004375	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
86416004376	active site
86416004377	putative substrate binding region [chemical binding]; other site
86416004378	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416004379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416004380	Walker A/P-loop; other site
86416004381	ATP binding site [chemical binding]; other site
86416004382	Q-loop/lid; other site
86416004383	ABC transporter signature motif; other site
86416004384	Walker B; other site
86416004385	D-loop; other site
86416004386	H-loop/switch region; other site
86416004387	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416004388	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
86416004389	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
86416004390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416004391	Walker A motif; other site
86416004392	ATP binding site [chemical binding]; other site
86416004393	Walker B motif; other site
86416004394	Homeodomain-like domain; Region: HTH_23; pfam13384
86416004395	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
86416004396	Integrase core domain; Region: rve; pfam00665
86416004397	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416004398	active site
86416004399	DNA binding site [nucleotide binding]
86416004400	Int/Topo IB signature motif; other site
86416004401	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
86416004402	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416004403	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
86416004404	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
86416004405	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416004406	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
86416004407	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
86416004408	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
86416004409	Multicopper oxidase; Region: Cu-oxidase; pfam00394
86416004410	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
86416004411	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416004412	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416004413	active site
86416004414	TDP-binding site; other site
86416004415	acceptor substrate-binding pocket; other site
86416004416	homodimer interface [polypeptide binding]; other site
86416004417	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
86416004418	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416004419	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
86416004420	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
86416004421	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
86416004422	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
86416004423	putative substrate-binding site; other site
86416004424	nickel binding site [ion binding]; other site
86416004425	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
86416004426	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
86416004427	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416004428	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
86416004429	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
86416004430	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
86416004431	HupF/HypC family; Region: HupF_HypC; pfam01455
86416004432	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
86416004433	dimerization interface [polypeptide binding]; other site
86416004434	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
86416004435	ATP binding site [chemical binding]; other site
86416004436	Acylphosphatase; Region: Acylphosphatase; pfam00708
86416004437	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
86416004438	HypF finger; Region: zf-HYPF; pfam07503
86416004439	HypF finger; Region: zf-HYPF; pfam07503
86416004440	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
86416004441	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
86416004442	active site
86416004443	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
86416004444	Predicted permeases [General function prediction only]; Region: COG0679
86416004445	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
86416004446	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
86416004447	active site
86416004448	catalytic residues [active]
86416004449	metal binding site [ion binding]; metal-binding site
86416004450	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416004451	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416004452	catalytic residues [active]
86416004453	catalytic nucleophile [active]
86416004454	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416004455	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416004456	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416004457	Synaptic Site I dimer interface [polypeptide binding]; other site
86416004458	DNA binding site [nucleotide binding]
86416004459	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
86416004460	MPN+ (JAMM) motif; other site
86416004461	Zinc-binding site [ion binding]; other site
86416004462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004463	Coenzyme A binding pocket [chemical binding]; other site
86416004464	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416004465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004466	Coenzyme A binding pocket [chemical binding]; other site
86416004467	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
86416004468	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
86416004469	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
86416004470	catalytic residue [active]
86416004471	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416004472	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416004473	dimer interface [polypeptide binding]; other site
86416004474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416004475	catalytic residue [active]
86416004476	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
86416004477	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
86416004478	catalytic residue [active]
86416004479	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416004480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004481	S-adenosylmethionine binding site [chemical binding]; other site
86416004482	spermidine synthase; Provisional; Region: PRK00811
86416004483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004484	S-adenosylmethionine binding site [chemical binding]; other site
86416004485	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
86416004486	EamA-like transporter family; Region: EamA; pfam00892
86416004487	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416004488	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
86416004489	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
86416004490	putative catalytic cysteine [active]
86416004491	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
86416004492	putative active site [active]
86416004493	metal binding site [ion binding]; metal-binding site
86416004494	Coenzyme A transferase; Region: CoA_trans; cl17247
86416004495	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
86416004496	acetoacetate decarboxylase; Provisional; Region: PRK02265
86416004497	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
86416004498	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416004499	tetramer interface [polypeptide binding]; other site
86416004500	catalytic Zn binding site [ion binding]; other site
86416004501	NADP binding site [chemical binding]; other site
86416004502	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416004503	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416004504	Amidohydrolase; Region: Amidohydro_2; pfam04909
86416004505	active site
86416004506	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
86416004507	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
86416004508	substrate binding pocket [chemical binding]; other site
86416004509	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416004510	MarR family; Region: MarR_2; pfam12802
86416004511	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
86416004512	active site
86416004513	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416004514	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416004515	catalytic residues [active]
86416004516	catalytic nucleophile [active]
86416004517	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416004518	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416004519	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416004520	Synaptic Site I dimer interface [polypeptide binding]; other site
86416004521	DNA binding site [nucleotide binding]
86416004522	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
86416004523	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
86416004524	HsdM N-terminal domain; Region: HsdM_N; pfam12161
86416004525	Methyltransferase domain; Region: Methyltransf_26; pfam13659
86416004526	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
86416004527	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
86416004528	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
86416004529	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
86416004530	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
86416004531	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
86416004532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416004533	ATP binding site [chemical binding]; other site
86416004534	putative Mg++ binding site [ion binding]; other site
86416004535	Organic solute transport protein 1; Region: Oscp1; pfam10188
86416004536	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416004537	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416004538	catalytic residues [active]
86416004539	catalytic nucleophile [active]
86416004540	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416004541	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416004542	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416004543	Synaptic Site I dimer interface [polypeptide binding]; other site
86416004544	DNA binding site [nucleotide binding]
86416004545	Homeodomain-like domain; Region: HTH_23; pfam13384
86416004546	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
86416004547	FAD binding domain; Region: FAD_binding_4; pfam01565
86416004548	Berberine and berberine like; Region: BBE; pfam08031
86416004549	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
86416004550	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
86416004551	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
86416004552	SecA binding site; other site
86416004553	Preprotein binding site; other site
86416004554	Transposase; Region: HTH_Tnp_1; cl17663
86416004555	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
86416004556	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416004557	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416004558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416004559	Walker A/P-loop; other site
86416004560	ATP binding site [chemical binding]; other site
86416004561	Q-loop/lid; other site
86416004562	ABC transporter signature motif; other site
86416004563	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416004564	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416004565	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416004566	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
86416004567	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
86416004568	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416004569	putative active site [active]
86416004570	putative NTP binding site [chemical binding]; other site
86416004571	putative nucleic acid binding site [nucleotide binding]; other site
86416004572	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416004573	putative transposase OrfB; Reviewed; Region: PHA02517
86416004574	Integrase core domain; Region: rve; pfam00665
86416004575	Transposase; Region: HTH_Tnp_1; pfam01527
86416004576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
86416004577	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416004578	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416004579	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
86416004580	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
86416004581	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416004582	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416004583	active site
86416004584	TDP-binding site; other site
86416004585	acceptor substrate-binding pocket; other site
86416004586	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
86416004587	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416004588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004589	S-adenosylmethionine binding site [chemical binding]; other site
86416004590	Chromate transporter; Region: Chromate_transp; pfam02417
86416004591	Chromate transporter; Region: Chromate_transp; pfam02417
86416004592	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
86416004593	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416004594	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416004595	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416004596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416004597	motif II; other site
86416004598	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416004599	Predicted integral membrane protein [Function unknown]; Region: COG5542
86416004600	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
86416004601	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416004602	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
86416004603	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
86416004604	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
86416004605	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
86416004606	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
86416004607	putative active site [active]
86416004608	HPr kinase/phosphorylase; Provisional; Region: PRK05428
86416004609	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
86416004610	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
86416004611	Hpr binding site; other site
86416004612	active site
86416004613	homohexamer subunit interaction site [polypeptide binding]; other site
86416004614	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
86416004615	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
86416004616	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
86416004617	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
86416004618	oligomer interface [polypeptide binding]; other site
86416004619	putative active site [active]
86416004620	metal binding site [ion binding]; metal-binding site
86416004621	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
86416004622	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416004623	active site
86416004624	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416004625	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
86416004626	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
86416004627	putative ATP binding site [chemical binding]; other site
86416004628	putative substrate interface [chemical binding]; other site
86416004629	Domain of unknown function DUF77; Region: DUF77; pfam01910
86416004630	Cation efflux family; Region: Cation_efflux; cl00316
86416004631	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
86416004632	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
86416004633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416004634	Walker A/P-loop; other site
86416004635	ATP binding site [chemical binding]; other site
86416004636	Q-loop/lid; other site
86416004637	ABC transporter signature motif; other site
86416004638	Walker B; other site
86416004639	D-loop; other site
86416004640	H-loop/switch region; other site
86416004641	ABC transporter; Region: ABC_tran_2; pfam12848
86416004642	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416004643	Protein of unknown function (DUF445); Region: DUF445; pfam04286
86416004644	Protein of unknown function (DUF445); Region: DUF445; pfam04286
86416004645	Domain of unknown function DUF21; Region: DUF21; pfam01595
86416004646	FOG: CBS domain [General function prediction only]; Region: COG0517
86416004647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
86416004648	Transporter associated domain; Region: CorC_HlyC; smart01091
86416004649	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
86416004650	active site
86416004651	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416004652	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
86416004653	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
86416004654	active site
86416004655	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
86416004656	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
86416004657	Histidine kinase; Region: His_kinase; pfam06580
86416004658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416004659	ATP binding site [chemical binding]; other site
86416004660	Mg2+ binding site [ion binding]; other site
86416004661	G-X-G motif; other site
86416004662	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
86416004663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416004664	active site
86416004665	phosphorylation site [posttranslational modification]
86416004666	intermolecular recognition site; other site
86416004667	dimerization interface [polypeptide binding]; other site
86416004668	LytTr DNA-binding domain; Region: LytTR; pfam04397
86416004669	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
86416004670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416004671	putative substrate translocation pore; other site
86416004672	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
86416004673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004674	S-adenosylmethionine binding site [chemical binding]; other site
86416004675	Spore germination protein; Region: Spore_permease; cl17796
86416004676	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
86416004677	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
86416004678	GGGtGRT protein; Region: GGGtGRT; pfam14057
86416004679	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
86416004680	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
86416004681	active site
86416004682	catalytic residues [active]
86416004683	DNA binding site [nucleotide binding]
86416004684	Int/Topo IB signature motif; other site
86416004685	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
86416004686	Double zinc ribbon; Region: DZR; pfam12773
86416004687	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416004688	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004689	non-specific DNA binding site [nucleotide binding]; other site
86416004690	salt bridge; other site
86416004691	sequence-specific DNA binding site [nucleotide binding]; other site
86416004692	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416004693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004694	non-specific DNA binding site [nucleotide binding]; other site
86416004695	salt bridge; other site
86416004696	sequence-specific DNA binding site [nucleotide binding]; other site
86416004697	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
86416004698	iron-sulfur cluster [ion binding]; other site
86416004699	[2Fe-2S] cluster binding site [ion binding]; other site
86416004700	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
86416004701	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
86416004702	Homeodomain-like domain; Region: HTH_23; pfam13384
86416004703	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416004704	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
86416004705	catalytic residues [active]
86416004706	catalytic nucleophile [active]
86416004707	Presynaptic Site I dimer interface [polypeptide binding]; other site
86416004708	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
86416004709	Synaptic Flat tetramer interface [polypeptide binding]; other site
86416004710	Synaptic Site I dimer interface [polypeptide binding]; other site
86416004711	DNA binding site [nucleotide binding]
86416004712	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
86416004713	Phage terminase large subunit; Region: Terminase_3; cl12054
86416004714	Terminase-like family; Region: Terminase_6; pfam03237
86416004715	Phage portal protein; Region: Phage_portal; pfam04860
86416004716	Phage-related protein [Function unknown]; Region: COG4695; cl01923
86416004717	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
86416004718	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
86416004719	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
86416004720	Phage capsid family; Region: Phage_capsid; pfam05065
86416004721	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
86416004722	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
86416004723	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
86416004724	Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537
86416004725	Phage-related protein [Function unknown]; Region: COG5412
86416004726	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
86416004727	N-acetyl-D-glucosamine binding site [chemical binding]; other site
86416004728	catalytic residue [active]
86416004729	Phage tail protein; Region: Sipho_tail; cl17486
86416004730	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
86416004731	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
86416004732	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
86416004733	Right handed beta helix region; Region: Beta_helix; pfam13229
86416004734	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
86416004735	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
86416004736	active site
86416004737	catalytic triad [active]
86416004738	oxyanion hole [active]
86416004739	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416004740	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416004741	active site
86416004742	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416004743	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416004744	Bacteriophage holin; Region: Phage_holin_1; cl02344
86416004745	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
86416004746	conserved cys residue [active]
86416004747	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416004748	non-specific DNA binding site [nucleotide binding]; other site
86416004749	salt bridge; other site
86416004750	sequence-specific DNA binding site [nucleotide binding]; other site
86416004751	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
86416004752	CAAX protease self-immunity; Region: Abi; pfam02517
86416004753	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004754	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416004755	Coenzyme A binding pocket [chemical binding]; other site
86416004756	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
86416004757	nucleoside/Zn binding site; other site
86416004758	dimer interface [polypeptide binding]; other site
86416004759	catalytic motif [active]
86416004760	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
86416004761	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
86416004762	DNA binding residues [nucleotide binding]
86416004763	dimer interface [polypeptide binding]; other site
86416004764	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
86416004765	OsmC-like protein; Region: OsmC; pfam02566
86416004766	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416004767	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004768	Coenzyme A binding pocket [chemical binding]; other site
86416004769	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
86416004770	Phospholipid methyltransferase; Region: PEMT; cl17370
86416004771	Uncharacterized conserved protein [Function unknown]; Region: COG3603
86416004772	Family description; Region: ACT_7; pfam13840
86416004773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416004774	Coenzyme A binding pocket [chemical binding]; other site
86416004775	AAA domain; Region: AAA_17; pfam13207
86416004776	AAA domain; Region: AAA_18; pfam13238
86416004777	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
86416004778	substrate binding site [chemical binding]; other site
86416004779	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
86416004780	putative active site [active]
86416004781	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416004782	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
86416004783	DNA binding residues [nucleotide binding]
86416004784	Flavodoxin domain; Region: Flavodoxin_5; cl17428
86416004785	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416004786	DJ-1 family protein; Region: not_thiJ; TIGR01383
86416004787	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
86416004788	conserved cys residue [active]
86416004789	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416004790	active site
86416004791	motif I; other site
86416004792	motif II; other site
86416004793	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
86416004794	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
86416004795	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416004796	putative trimer interface [polypeptide binding]; other site
86416004797	putative CoA binding site [chemical binding]; other site
86416004798	Transcriptional regulators [Transcription]; Region: MarR; COG1846
86416004799	MarR family; Region: MarR_2; pfam12802
86416004800	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
86416004801	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416004802	Walker A/P-loop; other site
86416004803	ATP binding site [chemical binding]; other site
86416004804	Q-loop/lid; other site
86416004805	ABC transporter signature motif; other site
86416004806	Walker B; other site
86416004807	D-loop; other site
86416004808	H-loop/switch region; other site
86416004809	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
86416004810	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
86416004811	active site
86416004812	homotetramer interface [polypeptide binding]; other site
86416004813	homodimer interface [polypeptide binding]; other site
86416004814	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
86416004815	DsrE/DsrF-like family; Region: DrsE; cl00672
86416004816	Protein of unknown function DUF45; Region: DUF45; pfam01863
86416004817	Predicted membrane protein [Function unknown]; Region: COG3462
86416004818	Short C-terminal domain; Region: SHOCT; pfam09851
86416004819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416004820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416004821	active site
86416004822	phosphorylation site [posttranslational modification]
86416004823	intermolecular recognition site; other site
86416004824	dimerization interface [polypeptide binding]; other site
86416004825	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416004826	DNA binding site [nucleotide binding]
86416004827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416004828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416004829	dimerization interface [polypeptide binding]; other site
86416004830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416004831	dimer interface [polypeptide binding]; other site
86416004832	phosphorylation site [posttranslational modification]
86416004833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416004834	ATP binding site [chemical binding]; other site
86416004835	Mg2+ binding site [ion binding]; other site
86416004836	G-X-G motif; other site
86416004837	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
86416004838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004839	S-adenosylmethionine binding site [chemical binding]; other site
86416004840	4Fe-4S binding domain; Region: Fer4_5; pfam12801
86416004841	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416004842	YtkA-like; Region: YtkA; pfam13115
86416004843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416004844	dimer interface [polypeptide binding]; other site
86416004845	phosphorylation site [posttranslational modification]
86416004846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416004847	ATP binding site [chemical binding]; other site
86416004848	Mg2+ binding site [ion binding]; other site
86416004849	G-X-G motif; other site
86416004850	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416004851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416004852	active site
86416004853	phosphorylation site [posttranslational modification]
86416004854	intermolecular recognition site; other site
86416004855	dimerization interface [polypeptide binding]; other site
86416004856	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416004857	DNA binding site [nucleotide binding]
86416004858	chorismate binding enzyme; Region: Chorismate_bind; cl10555
86416004859	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
86416004860	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
86416004861	dimer interface [polypeptide binding]; other site
86416004862	tetramer interface [polypeptide binding]; other site
86416004863	PYR/PP interface [polypeptide binding]; other site
86416004864	TPP binding site [chemical binding]; other site
86416004865	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
86416004866	TPP-binding site; other site
86416004867	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416004868	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416004869	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
86416004870	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
86416004871	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
86416004872	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
86416004873	putative substrate-binding site; other site
86416004874	nickel binding site [ion binding]; other site
86416004875	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
86416004876	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
86416004877	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416004878	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
86416004879	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
86416004880	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
86416004881	HupF/HypC family; Region: HupF_HypC; pfam01455
86416004882	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
86416004883	dimerization interface [polypeptide binding]; other site
86416004884	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
86416004885	ATP binding site [chemical binding]; other site
86416004886	Acylphosphatase; Region: Acylphosphatase; pfam00708
86416004887	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
86416004888	HypF finger; Region: zf-HYPF; pfam07503
86416004889	HypF finger; Region: zf-HYPF; pfam07503
86416004890	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
86416004891	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
86416004892	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
86416004893	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
86416004894	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416004895	metal-binding site [ion binding]
86416004896	Uncharacterized conserved protein [Function unknown]; Region: COG2836
86416004897	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
86416004898	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
86416004899	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
86416004900	EamA-like transporter family; Region: EamA; pfam00892
86416004901	EamA-like transporter family; Region: EamA; pfam00892
86416004902	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416004903	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
86416004904	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416004905	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416004906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416004907	motif II; other site
86416004908	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416004909	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
86416004910	Domain of unknown function DUF20; Region: UPF0118; pfam01594
86416004911	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
86416004912	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
86416004913	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
86416004914	substrate binding site [chemical binding]; other site
86416004915	oxyanion hole (OAH) forming residues; other site
86416004916	trimer interface [polypeptide binding]; other site
86416004917	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
86416004918	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
86416004919	acyl-activating enzyme (AAE) consensus motif; other site
86416004920	putative AMP binding site [chemical binding]; other site
86416004921	putative active site [active]
86416004922	putative CoA binding site [chemical binding]; other site
86416004923	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
86416004924	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
86416004925	metal binding site [ion binding]; metal-binding site
86416004926	substrate binding pocket [chemical binding]; other site
86416004927	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
86416004928	CoenzymeA binding site [chemical binding]; other site
86416004929	subunit interaction site [polypeptide binding]; other site
86416004930	PHB binding site; other site
86416004931	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
86416004932	UbiA prenyltransferase family; Region: UbiA; pfam01040
86416004933	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
86416004934	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
86416004935	substrate binding pocket [chemical binding]; other site
86416004936	chain length determination region; other site
86416004937	substrate-Mg2+ binding site; other site
86416004938	catalytic residues [active]
86416004939	aspartate-rich region 1; other site
86416004940	active site lid residues [active]
86416004941	aspartate-rich region 2; other site
86416004942	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
86416004943	NADH dehydrogenase subunit B; Validated; Region: PRK06411
86416004944	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
86416004945	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
86416004946	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
86416004947	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
86416004948	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
86416004949	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
86416004950	4Fe-4S binding domain; Region: Fer4; pfam00037
86416004951	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
86416004952	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
86416004953	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
86416004954	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
86416004955	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
86416004956	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
86416004957	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
86416004958	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
86416004959	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144
86416004960	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
86416004961	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416004962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
86416004963	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416004964	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416004965	GTPase RsgA; Reviewed; Region: PRK01889
86416004966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004967	S-adenosylmethionine binding site [chemical binding]; other site
86416004968	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
86416004969	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
86416004970	dimer interface [polypeptide binding]; other site
86416004971	active site
86416004972	catalytic residue [active]
86416004973	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
86416004974	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
86416004975	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
86416004976	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
86416004977	active site 1 [active]
86416004978	dimer interface [polypeptide binding]; other site
86416004979	hexamer interface [polypeptide binding]; other site
86416004980	active site 2 [active]
86416004981	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
86416004982	putative deacylase active site [active]
86416004983	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
86416004984	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
86416004985	active site
86416004986	metal binding site [ion binding]; metal-binding site
86416004987	homotetramer interface [polypeptide binding]; other site
86416004988	malate dehydrogenase; Provisional; Region: PRK13529
86416004989	Malic enzyme, N-terminal domain; Region: malic; pfam00390
86416004990	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
86416004991	NAD(P) binding site [chemical binding]; other site
86416004992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416004993	S-adenosylmethionine binding site [chemical binding]; other site
86416004994	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
86416004995	catalytic core [active]
86416004996	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
86416004997	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
86416004998	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
86416004999	substrate binding pocket [chemical binding]; other site
86416005000	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
86416005001	B12 binding site [chemical binding]; other site
86416005002	cobalt ligand [ion binding]; other site
86416005003	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
86416005004	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416005005	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
86416005006	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
86416005007	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
86416005008	Acyltransferase family; Region: Acyl_transf_3; pfam01757
86416005009	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
86416005010	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416005011	Heavy-metal-associated domain; Region: HMA; pfam00403
86416005012	metal-binding site [ion binding]
86416005013	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416005014	Soluble P-type ATPase [General function prediction only]; Region: COG4087
86416005015	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416005016	putative DNA binding site [nucleotide binding]; other site
86416005017	dimerization interface [polypeptide binding]; other site
86416005018	putative Zn2+ binding site [ion binding]; other site
86416005019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416005020	S-adenosylmethionine binding site [chemical binding]; other site
86416005021	hypothetical protein; Provisional; Region: PRK10281
86416005022	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
86416005023	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
86416005024	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
86416005025	dimerization interface [polypeptide binding]; other site
86416005026	ATP binding site [chemical binding]; other site
86416005027	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
86416005028	dimerization interface [polypeptide binding]; other site
86416005029	ATP binding site [chemical binding]; other site
86416005030	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
86416005031	putative active site [active]
86416005032	catalytic triad [active]
86416005033	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
86416005034	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
86416005035	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
86416005036	ATP binding site [chemical binding]; other site
86416005037	active site
86416005038	substrate binding site [chemical binding]; other site
86416005039	amidophosphoribosyltransferase; Provisional; Region: PRK05793
86416005040	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
86416005041	active site
86416005042	tetramer interface [polypeptide binding]; other site
86416005043	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416005044	active site
86416005045	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
86416005046	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
86416005047	dimerization interface [polypeptide binding]; other site
86416005048	putative ATP binding site [chemical binding]; other site
86416005049	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
86416005050	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
86416005051	active site
86416005052	substrate binding site [chemical binding]; other site
86416005053	cosubstrate binding site; other site
86416005054	catalytic site [active]
86416005055	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
86416005056	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
86416005057	purine monophosphate binding site [chemical binding]; other site
86416005058	dimer interface [polypeptide binding]; other site
86416005059	putative catalytic residues [active]
86416005060	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
86416005061	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
86416005062	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
86416005063	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
86416005064	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
86416005065	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
86416005066	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
86416005067	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
86416005068	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
86416005069	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
86416005070	CrcB-like protein; Region: CRCB; cl09114
86416005071	DNA polymerase I; Provisional; Region: PRK05755
86416005072	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
86416005073	active site
86416005074	metal binding site 1 [ion binding]; metal-binding site
86416005075	putative 5' ssDNA interaction site; other site
86416005076	metal binding site 3; metal-binding site
86416005077	metal binding site 2 [ion binding]; metal-binding site
86416005078	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
86416005079	putative DNA binding site [nucleotide binding]; other site
86416005080	putative metal binding site [ion binding]; other site
86416005081	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
86416005082	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
86416005083	active site
86416005084	DNA binding site [nucleotide binding]
86416005085	catalytic site [active]
86416005086	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
86416005087	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
86416005088	CoA-binding site [chemical binding]; other site
86416005089	ATP-binding [chemical binding]; other site
86416005090	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
86416005091	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
86416005092	N-acetyl-D-glucosamine binding site [chemical binding]; other site
86416005093	catalytic residue [active]
86416005094	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416005095	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
86416005096	active site
86416005097	motif I; other site
86416005098	motif II; other site
86416005099	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416005100	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
86416005101	Protein of unknown function, DUF606; Region: DUF606; pfam04657
86416005102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416005103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416005104	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416005105	dimerization interface [polypeptide binding]; other site
86416005106	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
86416005107	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
86416005108	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
86416005109	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
86416005110	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
86416005111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
86416005112	Radical SAM superfamily; Region: Radical_SAM; pfam04055
86416005113	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005114	FeS/SAM binding site; other site
86416005115	AAA domain; Region: AAA_17; pfam13207
86416005116	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416005117	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416005118	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416005119	putative active site [active]
86416005120	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416005121	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
86416005122	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416005123	active site turn [active]
86416005124	phosphorylation site [posttranslational modification]
86416005125	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
86416005126	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
86416005127	NAD binding site [chemical binding]; other site
86416005128	sugar binding site [chemical binding]; other site
86416005129	divalent metal binding site [ion binding]; other site
86416005130	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416005131	dimer interface [polypeptide binding]; other site
86416005132	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416005133	HPr interaction site; other site
86416005134	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416005135	active site
86416005136	phosphorylation site [posttranslational modification]
86416005137	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416005138	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
86416005139	putative NAD(P) binding site [chemical binding]; other site
86416005140	catalytic Zn binding site [ion binding]; other site
86416005141	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
86416005142	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
86416005143	FMN binding site [chemical binding]; other site
86416005144	dimer interface [polypeptide binding]; other site
86416005145	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
86416005146	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
86416005147	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
86416005148	BioY family; Region: BioY; pfam02632
86416005149	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
86416005150	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
86416005151	dimer interface [polypeptide binding]; other site
86416005152	active site
86416005153	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
86416005154	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
86416005155	AMP binding site [chemical binding]; other site
86416005156	active site
86416005157	acyl-activating enzyme (AAE) consensus motif; other site
86416005158	CoA binding site [chemical binding]; other site
86416005159	Domain of unknown function (DU1801); Region: DUF1801; cl17490
86416005160	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416005161	MarR family; Region: MarR_2; pfam12802
86416005162	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416005163	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
86416005164	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
86416005165	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
86416005166	PAS domain; Region: PAS_9; pfam13426
86416005167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416005168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416005169	dimer interface [polypeptide binding]; other site
86416005170	phosphorylation site [posttranslational modification]
86416005171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416005172	ATP binding site [chemical binding]; other site
86416005173	Mg2+ binding site [ion binding]; other site
86416005174	G-X-G motif; other site
86416005175	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
86416005176	dimer interface [polypeptide binding]; other site
86416005177	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416005178	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
86416005179	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
86416005180	dimer interface [polypeptide binding]; other site
86416005181	active site
86416005182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005183	FeS/SAM binding site; other site
86416005184	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
86416005185	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
86416005186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416005187	active site
86416005188	catalytic tetrad [active]
86416005189	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416005190	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
86416005191	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
86416005192	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416005193	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416005194	NodB motif; other site
86416005195	active site
86416005196	catalytic site [active]
86416005197	Zn binding site [ion binding]; other site
86416005198	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
86416005199	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
86416005200	Bacitracin resistance protein BacA; Region: BacA; pfam02673
86416005201	Uncharacterized conserved protein [Function unknown]; Region: COG1633
86416005202	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
86416005203	dinuclear metal binding motif [ion binding]; other site
86416005204	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416005205	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416005206	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
86416005207	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416005208	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
86416005209	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
86416005210	ACS interaction site; other site
86416005211	CODH interaction site; other site
86416005212	cubane metal cluster (B-cluster) [ion binding]; other site
86416005213	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
86416005214	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
86416005215	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
86416005216	P-loop; other site
86416005217	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416005218	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
86416005219	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
86416005220	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
86416005221	metal binding site [ion binding]; metal-binding site
86416005222	active site
86416005223	I-site; other site
86416005224	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
86416005225	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
86416005226	dimerization interface 3.5A [polypeptide binding]; other site
86416005227	active site
86416005228	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
86416005229	L-lactate permease; Region: Lactate_perm; cl00701
86416005230	hypothetical protein; Validated; Region: PRK02101
86416005231	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416005232	MULE transposase domain; Region: MULE; pfam10551
86416005233	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
86416005234	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
86416005235	Predicted permeases [General function prediction only]; Region: COG0679
86416005236	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
86416005237	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
86416005238	NAD(P) binding site [chemical binding]; other site
86416005239	catalytic residues [active]
86416005240	Predicted permeases [General function prediction only]; Region: COG0679
86416005241	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856
86416005242	Predicted dehydrogenase [General function prediction only]; Region: COG0579
86416005243	hydroxyglutarate oxidase; Provisional; Region: PRK11728
86416005244	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
86416005245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
86416005246	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
86416005247	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
86416005248	NAD binding site [chemical binding]; other site
86416005249	Protein of unknown function (DUF1667); Region: DUF1667; cl17602
86416005250	S-ribosylhomocysteinase; Provisional; Region: PRK02260
86416005251	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
86416005252	Sporulation related domain; Region: SPOR; pfam05036
86416005253	Maf-like protein; Reviewed; Region: PRK00078
86416005254	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
86416005255	active site
86416005256	dimer interface [polypeptide binding]; other site
86416005257	hypothetical protein; Reviewed; Region: PRK00024
86416005258	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
86416005259	MPN+ (JAMM) motif; other site
86416005260	Zinc-binding site [ion binding]; other site
86416005261	rod shape-determining protein MreB; Provisional; Region: PRK13927
86416005262	MreB and similar proteins; Region: MreB_like; cd10225
86416005263	nucleotide binding site [chemical binding]; other site
86416005264	Mg binding site [ion binding]; other site
86416005265	putative protofilament interaction site [polypeptide binding]; other site
86416005266	RodZ interaction site [polypeptide binding]; other site
86416005267	rod shape-determining protein MreC; Provisional; Region: PRK13922
86416005268	rod shape-determining protein MreC; Region: MreC; pfam04085
86416005269	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
86416005270	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416005271	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416005272	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416005273	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416005274	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416005275	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416005276	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416005277	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416005278	septum formation inhibitor; Reviewed; Region: minC; PRK00513
86416005279	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
86416005280	septum site-determining protein MinD; Region: minD_bact; TIGR01968
86416005281	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
86416005282	Switch I; other site
86416005283	Switch II; other site
86416005284	Septum formation topological specificity factor MinE; Region: MinE; cl00538
86416005285	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
86416005286	Peptidase family M23; Region: Peptidase_M23; pfam01551
86416005287	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
86416005288	Peptidase family M50; Region: Peptidase_M50; pfam02163
86416005289	active site
86416005290	putative substrate binding region [chemical binding]; other site
86416005291	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
86416005292	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
86416005293	B12 binding site [chemical binding]; other site
86416005294	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005295	FeS/SAM binding site; other site
86416005296	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
86416005297	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
86416005298	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
86416005299	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
86416005300	homodimer interface [polypeptide binding]; other site
86416005301	oligonucleotide binding site [chemical binding]; other site
86416005302	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
86416005303	Protein of unknown function (DUF464); Region: DUF464; pfam04327
86416005304	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
86416005305	GTPase CgtA; Reviewed; Region: obgE; PRK12297
86416005306	GTP1/OBG; Region: GTP1_OBG; pfam01018
86416005307	Obg GTPase; Region: Obg; cd01898
86416005308	G1 box; other site
86416005309	GTP/Mg2+ binding site [chemical binding]; other site
86416005310	Switch I region; other site
86416005311	G2 box; other site
86416005312	G3 box; other site
86416005313	Switch II region; other site
86416005314	G4 box; other site
86416005315	G5 box; other site
86416005316	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
86416005317	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
86416005318	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
86416005319	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
86416005320	active site
86416005321	(T/H)XGH motif; other site
86416005322	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416005323	Zn2+ binding site [ion binding]; other site
86416005324	Mg2+ binding site [ion binding]; other site
86416005325	Transcriptional regulator [Transcription]; Region: LytR; COG1316
86416005326	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
86416005327	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
86416005328	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
86416005329	active site
86416005330	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
86416005331	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
86416005332	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
86416005333	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
86416005334	SLBB domain; Region: SLBB; pfam10531
86416005335	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
86416005336	Competence protein; Region: Competence; pfam03772
86416005337	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
86416005338	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
86416005339	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
86416005340	germination protease; Provisional; Region: PRK12362
86416005341	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
86416005342	stage II sporulation protein P; Region: spore_II_P; TIGR02867
86416005343	GTP-binding protein LepA; Provisional; Region: PRK05433
86416005344	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
86416005345	G1 box; other site
86416005346	putative GEF interaction site [polypeptide binding]; other site
86416005347	GTP/Mg2+ binding site [chemical binding]; other site
86416005348	Switch I region; other site
86416005349	G2 box; other site
86416005350	G3 box; other site
86416005351	Switch II region; other site
86416005352	G4 box; other site
86416005353	G5 box; other site
86416005354	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
86416005355	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
86416005356	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
86416005357	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
86416005358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005359	FeS/SAM binding site; other site
86416005360	HemN C-terminal domain; Region: HemN_C; pfam06969
86416005361	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
86416005362	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
86416005363	GrpE; Region: GrpE; pfam01025
86416005364	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
86416005365	dimer interface [polypeptide binding]; other site
86416005366	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
86416005367	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
86416005368	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
86416005369	nucleotide binding site [chemical binding]; other site
86416005370	NEF interaction site [polypeptide binding]; other site
86416005371	SBD interface [polypeptide binding]; other site
86416005372	chaperone protein DnaJ; Provisional; Region: PRK14297
86416005373	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
86416005374	HSP70 interaction site [polypeptide binding]; other site
86416005375	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
86416005376	substrate binding site [polypeptide binding]; other site
86416005377	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
86416005378	Zn binding sites [ion binding]; other site
86416005379	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
86416005380	dimer interface [polypeptide binding]; other site
86416005381	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
86416005382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416005383	S-adenosylmethionine binding site [chemical binding]; other site
86416005384	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
86416005385	RNA methyltransferase, RsmE family; Region: TIGR00046
86416005386	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
86416005387	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
86416005388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005389	FeS/SAM binding site; other site
86416005390	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
86416005391	nucleotide binding site/active site [active]
86416005392	HIT family signature motif; other site
86416005393	catalytic residue [active]
86416005394	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
86416005395	Yqey-like protein; Region: YqeY; pfam09424
86416005396	YabP family; Region: YabP; cl06766
86416005397	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
86416005398	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
86416005399	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
86416005400	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
86416005401	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416005402	Zn2+ binding site [ion binding]; other site
86416005403	Mg2+ binding site [ion binding]; other site
86416005404	metal-binding heat shock protein; Provisional; Region: PRK00016
86416005405	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
86416005406	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
86416005407	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
86416005408	active site
86416005409	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
86416005410	active site
86416005411	catalytic motif [active]
86416005412	Zn binding site [ion binding]; other site
86416005413	GTPase Era; Reviewed; Region: era; PRK00089
86416005414	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
86416005415	G1 box; other site
86416005416	GTP/Mg2+ binding site [chemical binding]; other site
86416005417	Switch I region; other site
86416005418	G2 box; other site
86416005419	Switch II region; other site
86416005420	G3 box; other site
86416005421	G4 box; other site
86416005422	G5 box; other site
86416005423	KH domain; Region: KH_2; pfam07650
86416005424	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
86416005425	Recombination protein O N terminal; Region: RecO_N; pfam11967
86416005426	Recombination protein O C terminal; Region: RecO_C; pfam02565
86416005427	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
86416005428	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
86416005429	HTH domain; Region: HTH_11; pfam08279
86416005430	FOG: CBS domain [General function prediction only]; Region: COG0517
86416005431	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
86416005432	pyruvate phosphate dikinase; Provisional; Region: PRK09279
86416005433	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
86416005434	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
86416005435	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
86416005436	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
86416005437	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416005438	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
86416005439	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416005440	Zn2+ binding site [ion binding]; other site
86416005441	Mg2+ binding site [ion binding]; other site
86416005442	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
86416005443	DNA primase; Validated; Region: dnaG; PRK05667
86416005444	CHC2 zinc finger; Region: zf-CHC2; pfam01807
86416005445	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
86416005446	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
86416005447	active site
86416005448	metal binding site [ion binding]; metal-binding site
86416005449	interdomain interaction site; other site
86416005450	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
86416005451	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
86416005452	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
86416005453	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
86416005454	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416005455	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
86416005456	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416005457	DNA binding residues [nucleotide binding]
86416005458	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
86416005459	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
86416005460	Family of unknown function (DUF633); Region: DUF633; pfam04816
86416005461	Uncharacterized conserved protein [Function unknown]; Region: COG0327
86416005462	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
86416005463	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
86416005464	Putative zinc ribbon domain; Region: DUF164; pfam02591
86416005465	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
86416005466	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416005467	homodimer interface [polypeptide binding]; other site
86416005468	substrate-cofactor binding pocket; other site
86416005469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416005470	catalytic residue [active]
86416005471	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
86416005472	EamA-like transporter family; Region: EamA; pfam00892
86416005473	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
86416005474	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
86416005475	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
86416005476	PYR/PP interface [polypeptide binding]; other site
86416005477	dimer interface [polypeptide binding]; other site
86416005478	TPP binding site [chemical binding]; other site
86416005479	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
86416005480	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
86416005481	TPP-binding site [chemical binding]; other site
86416005482	dimer interface [polypeptide binding]; other site
86416005483	ketol-acid reductoisomerase; Provisional; Region: PRK05479
86416005484	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
86416005485	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
86416005486	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
86416005487	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
86416005488	substrate binding site [chemical binding]; other site
86416005489	ligand binding site [chemical binding]; other site
86416005490	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
86416005491	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
86416005492	substrate binding site [chemical binding]; other site
86416005493	tartrate dehydrogenase; Region: TTC; TIGR02089
86416005494	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
86416005495	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
86416005496	Sulfatase; Region: Sulfatase; pfam00884
86416005497	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
86416005498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416005499	S-adenosylmethionine binding site [chemical binding]; other site
86416005500	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416005501	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416005502	non-specific DNA binding site [nucleotide binding]; other site
86416005503	salt bridge; other site
86416005504	sequence-specific DNA binding site [nucleotide binding]; other site
86416005505	Domain of unknown function (DUF955); Region: DUF955; pfam06114
86416005506	Catalytic domain of Protein Kinases; Region: PKc; cd00180
86416005507	active site
86416005508	ATP binding site [chemical binding]; other site
86416005509	substrate binding site [chemical binding]; other site
86416005510	activation loop (A-loop); other site
86416005511	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
86416005512	putative active site [active]
86416005513	AAA domain; Region: AAA_31; pfam13614
86416005514	Helix-turn-helix domain; Region: HTH_36; pfam13730
86416005515	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416005516	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
86416005517	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
86416005518	cofactor binding site; other site
86416005519	DNA binding site [nucleotide binding]
86416005520	substrate interaction site [chemical binding]; other site
86416005521	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
86416005522	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
86416005523	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416005524	ATP binding site [chemical binding]; other site
86416005525	putative Mg++ binding site [ion binding]; other site
86416005526	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416005527	nucleotide binding region [chemical binding]; other site
86416005528	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
86416005529	ATP-binding site [chemical binding]; other site
86416005530	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
86416005531	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
86416005532	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
86416005533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
86416005534	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
86416005535	PLD-like domain; Region: PLDc_2; pfam13091
86416005536	putative active site [active]
86416005537	putative catalytic site [active]
86416005538	transposase/IS protein; Provisional; Region: PRK09183
86416005539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416005540	Walker A motif; other site
86416005541	ATP binding site [chemical binding]; other site
86416005542	Walker B motif; other site
86416005543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
86416005544	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
86416005545	Integrase core domain; Region: rve; pfam00665
86416005546	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
86416005547	Part of AAA domain; Region: AAA_19; pfam13245
86416005548	Family description; Region: UvrD_C_2; pfam13538
86416005549	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
86416005550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
86416005551	transcriptional repressor DicA; Reviewed; Region: PRK09706
86416005552	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
86416005553	active site
86416005554	DNA binding site [nucleotide binding]
86416005555	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
86416005556	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
86416005557	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416005558	active site
86416005559	DNA binding site [nucleotide binding]
86416005560	Int/Topo IB signature motif; other site
86416005561	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
86416005562	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416005563	active site
86416005564	DNA binding site [nucleotide binding]
86416005565	Int/Topo IB signature motif; other site
86416005566	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
86416005567	Ligand binding site; other site
86416005568	Putative Catalytic site; other site
86416005569	DXD motif; other site
86416005570	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
86416005571	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
86416005572	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416005573	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416005574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416005575	active site
86416005576	phosphorylation site [posttranslational modification]
86416005577	intermolecular recognition site; other site
86416005578	dimerization interface [polypeptide binding]; other site
86416005579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416005580	DNA binding site [nucleotide binding]
86416005581	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
86416005582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416005583	dimer interface [polypeptide binding]; other site
86416005584	phosphorylation site [posttranslational modification]
86416005585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416005586	ATP binding site [chemical binding]; other site
86416005587	Mg2+ binding site [ion binding]; other site
86416005588	G-X-G motif; other site
86416005589	Epoxide hydrolase N terminus; Region: EHN; pfam06441
86416005590	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416005591	Helix-turn-helix domain; Region: HTH_18; pfam12833
86416005592	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416005593	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416005594	Transcriptional regulator PadR-like family; Region: PadR; cl17335
86416005595	Fic family protein [Function unknown]; Region: COG3177
86416005596	Fic/DOC family; Region: Fic; pfam02661
86416005597	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
86416005598	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
86416005599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416005600	Walker A motif; other site
86416005601	ATP binding site [chemical binding]; other site
86416005602	Walker B motif; other site
86416005603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
86416005604	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
86416005605	metal ion-dependent adhesion site (MIDAS); other site
86416005606	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
86416005607	Isochorismatase family; Region: Isochorismatase; pfam00857
86416005608	catalytic triad [active]
86416005609	conserved cis-peptide bond; other site
86416005610	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
86416005611	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
86416005612	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
86416005613	FAD binding site [chemical binding]; other site
86416005614	homotetramer interface [polypeptide binding]; other site
86416005615	substrate binding pocket [chemical binding]; other site
86416005616	catalytic base [active]
86416005617	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
86416005618	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
86416005619	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
86416005620	Rubredoxin; Region: Rubredoxin; pfam00301
86416005621	iron binding site [ion binding]; other site
86416005622	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
86416005623	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416005624	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416005625	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
86416005626	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
86416005627	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
86416005628	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
86416005629	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
86416005630	substrate binding site [chemical binding]; other site
86416005631	ATP binding site [chemical binding]; other site
86416005632	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416005633	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416005634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416005635	hybrid cluster protein; Provisional; Region: PRK05290
86416005636	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416005637	ACS interaction site; other site
86416005638	CODH interaction site; other site
86416005639	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416005640	ACS interaction site; other site
86416005641	CODH interaction site; other site
86416005642	metal cluster binding site [ion binding]; other site
86416005643	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
86416005644	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416005645	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416005646	NodB motif; other site
86416005647	active site
86416005648	catalytic site [active]
86416005649	Zn binding site [ion binding]; other site
86416005650	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416005651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416005652	dimer interface [polypeptide binding]; other site
86416005653	conserved gate region; other site
86416005654	putative PBP binding loops; other site
86416005655	ABC-ATPase subunit interface; other site
86416005656	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416005657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416005658	dimer interface [polypeptide binding]; other site
86416005659	conserved gate region; other site
86416005660	putative PBP binding loops; other site
86416005661	ABC-ATPase subunit interface; other site
86416005662	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416005663	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416005664	Walker A/P-loop; other site
86416005665	ATP binding site [chemical binding]; other site
86416005666	Q-loop/lid; other site
86416005667	ABC transporter signature motif; other site
86416005668	Walker B; other site
86416005669	D-loop; other site
86416005670	H-loop/switch region; other site
86416005671	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
86416005672	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
86416005673	putative FMN binding site [chemical binding]; other site
86416005674	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
86416005675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005676	FeS/SAM binding site; other site
86416005677	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416005678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416005679	S-adenosylmethionine binding site [chemical binding]; other site
86416005680	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
86416005681	RuvA N terminal domain; Region: RuvA_N; pfam01330
86416005682	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
86416005683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416005684	Walker A motif; other site
86416005685	ATP binding site [chemical binding]; other site
86416005686	Walker B motif; other site
86416005687	arginine finger; other site
86416005688	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
86416005689	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
86416005690	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
86416005691	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
86416005692	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
86416005693	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
86416005694	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
86416005695	Protein of unknown function (DUF4001); Region: DUF4001; cl14848
86416005696	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
86416005697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005698	FeS/SAM binding site; other site
86416005699	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416005700	protein-export membrane protein SecD; Region: secD; TIGR01129
86416005701	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
86416005702	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
86416005703	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
86416005704	Protein export membrane protein; Region: SecD_SecF; pfam02355
86416005705	DHH family; Region: DHH; pfam01368
86416005706	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416005707	active site
86416005708	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
86416005709	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416005710	Zn2+ binding site [ion binding]; other site
86416005711	Mg2+ binding site [ion binding]; other site
86416005712	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
86416005713	synthetase active site [active]
86416005714	NTP binding site [chemical binding]; other site
86416005715	metal binding site [ion binding]; metal-binding site
86416005716	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
86416005717	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
86416005718	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
86416005719	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
86416005720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005721	FeS/SAM binding site; other site
86416005722	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
86416005723	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
86416005724	dimer interface [polypeptide binding]; other site
86416005725	motif 1; other site
86416005726	active site
86416005727	motif 2; other site
86416005728	motif 3; other site
86416005729	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
86416005730	anticodon binding site; other site
86416005731	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
86416005732	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
86416005733	dimer interface [polypeptide binding]; other site
86416005734	anticodon binding site; other site
86416005735	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
86416005736	homodimer interface [polypeptide binding]; other site
86416005737	motif 1; other site
86416005738	active site
86416005739	motif 2; other site
86416005740	GAD domain; Region: GAD; pfam02938
86416005741	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
86416005742	motif 3; other site
86416005743	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
86416005744	Uncharacterized conserved protein [Function unknown]; Region: COG2966
86416005745	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
86416005746	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
86416005747	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
86416005748	dimer interface [polypeptide binding]; other site
86416005749	active site
86416005750	glycine-pyridoxal phosphate binding site [chemical binding]; other site
86416005751	folate binding site [chemical binding]; other site
86416005752	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
86416005753	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
86416005754	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
86416005755	Family description; Region: UvrD_C_2; pfam13538
86416005756	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
86416005757	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
86416005758	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
86416005759	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416005760	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416005761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416005762	WHG domain; Region: WHG; pfam13305
86416005763	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416005764	Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044
86416005765	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
86416005766	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
86416005767	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
86416005768	trimer interface [polypeptide binding]; other site
86416005769	active site
86416005770	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416005771	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416005772	active site
86416005773	catalytic tetrad [active]
86416005774	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
86416005775	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
86416005776	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
86416005777	FAD binding site [chemical binding]; other site
86416005778	Acylphosphatase; Region: Acylphosphatase; cl00551
86416005779	thymidylate synthase; Reviewed; Region: thyA; PRK01827
86416005780	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
86416005781	dimerization interface [polypeptide binding]; other site
86416005782	active site
86416005783	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
86416005784	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
86416005785	folate binding site [chemical binding]; other site
86416005786	NADP+ binding site [chemical binding]; other site
86416005787	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416005788	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416005789	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416005790	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416005791	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
86416005792	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
86416005793	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
86416005794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416005795	Coenzyme A binding pocket [chemical binding]; other site
86416005796	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
86416005797	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416005798	FeS/SAM binding site; other site
86416005799	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
86416005800	MgtC family; Region: MgtC; pfam02308
86416005801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416005802	putative substrate translocation pore; other site
86416005803	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416005804	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
86416005805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416005806	motif II; other site
86416005807	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416005808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416005809	Coenzyme A binding pocket [chemical binding]; other site
86416005810	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
86416005811	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
86416005812	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
86416005813	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
86416005814	putative active site [active]
86416005815	metal binding site [ion binding]; metal-binding site
86416005816	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
86416005817	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
86416005818	Walker A/P-loop; other site
86416005819	ATP binding site [chemical binding]; other site
86416005820	Q-loop/lid; other site
86416005821	ABC transporter signature motif; other site
86416005822	Walker B; other site
86416005823	D-loop; other site
86416005824	H-loop/switch region; other site
86416005825	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
86416005826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416005827	dimer interface [polypeptide binding]; other site
86416005828	conserved gate region; other site
86416005829	putative PBP binding loops; other site
86416005830	ABC-ATPase subunit interface; other site
86416005831	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
86416005832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416005833	dimer interface [polypeptide binding]; other site
86416005834	conserved gate region; other site
86416005835	putative PBP binding loops; other site
86416005836	ABC-ATPase subunit interface; other site
86416005837	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
86416005838	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
86416005839	D-glutamate deacylase; Validated; Region: PRK09061
86416005840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416005841	active site
86416005842	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416005843	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
86416005844	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
86416005845	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
86416005846	generic binding surface II; other site
86416005847	generic binding surface I; other site
86416005848	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416005849	Zn2+ binding site [ion binding]; other site
86416005850	Mg2+ binding site [ion binding]; other site
86416005851	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
86416005852	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
86416005853	Catalytic site [active]
86416005854	glycogen synthase; Provisional; Region: glgA; PRK00654
86416005855	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
86416005856	ADP-binding pocket [chemical binding]; other site
86416005857	homodimer interface [polypeptide binding]; other site
86416005858	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
86416005859	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
86416005860	ligand binding site; other site
86416005861	oligomer interface; other site
86416005862	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
86416005863	dimer interface [polypeptide binding]; other site
86416005864	N-terminal domain interface [polypeptide binding]; other site
86416005865	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
86416005866	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
86416005867	ligand binding site; other site
86416005868	oligomer interface; other site
86416005869	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
86416005870	dimer interface [polypeptide binding]; other site
86416005871	N-terminal domain interface [polypeptide binding]; other site
86416005872	sulfate 1 binding site; other site
86416005873	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
86416005874	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
86416005875	manganese transport transcriptional regulator; Provisional; Region: PRK03902
86416005876	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
86416005877	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
86416005878	Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085
86416005879	active site
86416005880	putative catalytic site [active]
86416005881	phosphate binding site A [ion binding]; other site
86416005882	DNA binding site [nucleotide binding]
86416005883	metal binding site A [ion binding]; metal-binding site
86416005884	putative AP binding site [nucleotide binding]; other site
86416005885	putative metal binding site B [ion binding]; other site
86416005886	phosphate binding site B [ion binding]; other site
86416005887	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
86416005888	S1 domain; Region: S1_2; pfam13509
86416005889	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
86416005890	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416005891	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416005892	ABC transporter; Region: ABC_tran_2; pfam12848
86416005893	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416005894	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
86416005895	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
86416005896	G1 box; other site
86416005897	GTP/Mg2+ binding site [chemical binding]; other site
86416005898	Switch I region; other site
86416005899	G2 box; other site
86416005900	Switch II region; other site
86416005901	G3 box; other site
86416005902	G4 box; other site
86416005903	G5 box; other site
86416005904	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
86416005905	Aspartase; Region: Aspartase; cd01357
86416005906	active sites [active]
86416005907	tetramer interface [polypeptide binding]; other site
86416005908	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
86416005909	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
86416005910	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
86416005911	Peptidase M16C associated; Region: M16C_assoc; pfam08367
86416005912	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
86416005913	homodimer interface [polypeptide binding]; other site
86416005914	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
86416005915	active site pocket [active]
86416005916	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
86416005917	DNA-binding site [nucleotide binding]; DNA binding site
86416005918	RNA-binding motif; other site
86416005919	Predicted membrane protein [Function unknown]; Region: COG4684
86416005920	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
86416005921	recombination factor protein RarA; Reviewed; Region: PRK13342
86416005922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416005923	Walker A motif; other site
86416005924	ATP binding site [chemical binding]; other site
86416005925	Walker B motif; other site
86416005926	arginine finger; other site
86416005927	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
86416005928	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
86416005929	DEAD_2; Region: DEAD_2; pfam06733
86416005930	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
86416005931	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
86416005932	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
86416005933	active site
86416005934	dimer interface [polypeptide binding]; other site
86416005935	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
86416005936	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
86416005937	active site
86416005938	FMN binding site [chemical binding]; other site
86416005939	substrate binding site [chemical binding]; other site
86416005940	3Fe-4S cluster binding site [ion binding]; other site
86416005941	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
86416005942	domain interface; other site
86416005943	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
86416005944	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
86416005945	Predicted transcriptional regulator [Transcription]; Region: COG1959
86416005946	Transcriptional regulator; Region: Rrf2; cl17282
86416005947	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
86416005948	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
86416005949	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416005950	catalytic residue [active]
86416005951	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
86416005952	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
86416005953	trimerization site [polypeptide binding]; other site
86416005954	active site
86416005955	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
86416005956	PRC-barrel domain; Region: PRC; pfam05239
86416005957	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
86416005958	Domain of unknown function DUF20; Region: UPF0118; pfam01594
86416005959	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
86416005960	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
86416005961	motif 1; other site
86416005962	active site
86416005963	motif 2; other site
86416005964	motif 3; other site
86416005965	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
86416005966	hypothetical protein; Provisional; Region: PRK05473
86416005967	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
86416005968	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
86416005969	ferric uptake regulator; Provisional; Region: fur; PRK09462
86416005970	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
86416005971	metal binding site 2 [ion binding]; metal-binding site
86416005972	putative DNA binding helix; other site
86416005973	metal binding site 1 [ion binding]; metal-binding site
86416005974	dimer interface [polypeptide binding]; other site
86416005975	structural Zn2+ binding site [ion binding]; other site
86416005976	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
86416005977	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416005978	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
86416005979	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
86416005980	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
86416005981	G1 box; other site
86416005982	putative GEF interaction site [polypeptide binding]; other site
86416005983	GTP/Mg2+ binding site [chemical binding]; other site
86416005984	Switch I region; other site
86416005985	G2 box; other site
86416005986	G3 box; other site
86416005987	Switch II region; other site
86416005988	G4 box; other site
86416005989	G5 box; other site
86416005990	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
86416005991	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
86416005992	YceG-like family; Region: YceG; pfam02618
86416005993	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
86416005994	dimerization interface [polypeptide binding]; other site
86416005995	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
86416005996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416005997	S-adenosylmethionine binding site [chemical binding]; other site
86416005998	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
86416005999	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
86416006000	Peptidase family U32; Region: Peptidase_U32; pfam01136
86416006001	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
86416006002	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416006003	sporulation sigma factor SigK; Reviewed; Region: PRK05803
86416006004	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416006005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416006006	DNA binding residues [nucleotide binding]
86416006007	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
86416006008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416006009	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
86416006010	Walker A motif; other site
86416006011	Walker A/P-loop; other site
86416006012	ATP binding site [chemical binding]; other site
86416006013	ATP binding site [chemical binding]; other site
86416006014	Walker B motif; other site
86416006015	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
86416006016	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
86416006017	DXD motif; other site
86416006018	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
86416006019	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416006020	nucleotide binding site [chemical binding]; other site
86416006021	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
86416006022	Cell division protein FtsA; Region: FtsA; pfam14450
86416006023	cell division protein FtsZ; Validated; Region: PRK09330
86416006024	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
86416006025	nucleotide binding site [chemical binding]; other site
86416006026	SulA interaction site; other site
86416006027	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
86416006028	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
86416006029	sporulation sigma factor SigE; Reviewed; Region: PRK08301
86416006030	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416006031	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416006032	DNA binding residues [nucleotide binding]
86416006033	sporulation sigma factor SigG; Reviewed; Region: PRK08215
86416006034	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416006035	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
86416006036	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416006037	DNA binding residues [nucleotide binding]
86416006038	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
86416006039	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
86416006040	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
86416006041	ATP cone domain; Region: ATP-cone; pfam03477
86416006042	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
86416006043	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
86416006044	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416006045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416006046	active site
86416006047	phosphorylation site [posttranslational modification]
86416006048	intermolecular recognition site; other site
86416006049	dimerization interface [polypeptide binding]; other site
86416006050	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416006051	DNA binding site [nucleotide binding]
86416006052	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416006053	dimerization interface [polypeptide binding]; other site
86416006054	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
86416006055	PAS domain; Region: PAS; smart00091
86416006056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416006057	dimer interface [polypeptide binding]; other site
86416006058	phosphorylation site [posttranslational modification]
86416006059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416006060	ATP binding site [chemical binding]; other site
86416006061	Mg2+ binding site [ion binding]; other site
86416006062	G-X-G motif; other site
86416006063	Cache domain; Region: Cache_1; pfam02743
86416006064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416006065	dimerization interface [polypeptide binding]; other site
86416006066	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
86416006067	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
86416006068	dimer interface [polypeptide binding]; other site
86416006069	putative CheW interface [polypeptide binding]; other site
86416006070	PBP superfamily domain; Region: PBP_like_2; cl17296
86416006071	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
86416006072	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
86416006073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416006074	dimer interface [polypeptide binding]; other site
86416006075	conserved gate region; other site
86416006076	putative PBP binding loops; other site
86416006077	ABC-ATPase subunit interface; other site
86416006078	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
86416006079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416006080	dimer interface [polypeptide binding]; other site
86416006081	conserved gate region; other site
86416006082	putative PBP binding loops; other site
86416006083	ABC-ATPase subunit interface; other site
86416006084	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
86416006085	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
86416006086	Walker A/P-loop; other site
86416006087	ATP binding site [chemical binding]; other site
86416006088	Q-loop/lid; other site
86416006089	ABC transporter signature motif; other site
86416006090	Walker B; other site
86416006091	D-loop; other site
86416006092	H-loop/switch region; other site
86416006093	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
86416006094	PhoU domain; Region: PhoU; pfam01895
86416006095	PhoU domain; Region: PhoU; pfam01895
86416006096	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
86416006097	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
86416006098	Protein of unknown function (DUF512); Region: DUF512; pfam04459
86416006099	GTP-binding protein Der; Reviewed; Region: PRK00093
86416006100	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
86416006101	G1 box; other site
86416006102	GTP/Mg2+ binding site [chemical binding]; other site
86416006103	Switch I region; other site
86416006104	G2 box; other site
86416006105	Switch II region; other site
86416006106	G3 box; other site
86416006107	G4 box; other site
86416006108	G5 box; other site
86416006109	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
86416006110	G1 box; other site
86416006111	GTP/Mg2+ binding site [chemical binding]; other site
86416006112	Switch I region; other site
86416006113	G2 box; other site
86416006114	G3 box; other site
86416006115	Switch II region; other site
86416006116	G4 box; other site
86416006117	G5 box; other site
86416006118	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
86416006119	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
86416006120	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
86416006121	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
86416006122	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
86416006123	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
86416006124	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416006125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416006126	homodimer interface [polypeptide binding]; other site
86416006127	catalytic residue [active]
86416006128	hypothetical protein; Provisional; Region: PRK11820
86416006129	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
86416006130	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
86416006131	hypothetical protein; Provisional; Region: PRK04323
86416006132	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
86416006133	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
86416006134	catalytic site [active]
86416006135	G-X2-G-X-G-K; other site
86416006136	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
86416006137	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
86416006138	Flavoprotein; Region: Flavoprotein; pfam02441
86416006139	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
86416006140	primosome assembly protein PriA; Validated; Region: PRK05580
86416006141	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416006142	ATP binding site [chemical binding]; other site
86416006143	putative Mg++ binding site [ion binding]; other site
86416006144	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
86416006145	helicase superfamily c-terminal domain; Region: HELICc; smart00490
86416006146	ATP-binding site [chemical binding]; other site
86416006147	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
86416006148	active site
86416006149	catalytic residues [active]
86416006150	metal binding site [ion binding]; metal-binding site
86416006151	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
86416006152	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
86416006153	putative active site [active]
86416006154	substrate binding site [chemical binding]; other site
86416006155	putative cosubstrate binding site; other site
86416006156	catalytic site [active]
86416006157	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
86416006158	substrate binding site [chemical binding]; other site
86416006159	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
86416006160	16S rRNA methyltransferase B; Provisional; Region: PRK14902
86416006161	NusB family; Region: NusB; pfam01029
86416006162	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
86416006163	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
86416006164	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416006165	FeS/SAM binding site; other site
86416006166	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
86416006167	active site
86416006168	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
86416006169	Catalytic domain of Protein Kinases; Region: PKc; cd00180
86416006170	active site
86416006171	ATP binding site [chemical binding]; other site
86416006172	substrate binding site [chemical binding]; other site
86416006173	activation loop (A-loop); other site
86416006174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
86416006175	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
86416006176	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
86416006177	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
86416006178	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
86416006179	GTPase RsgA; Reviewed; Region: PRK00098
86416006180	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
86416006181	RNA binding site [nucleotide binding]; other site
86416006182	homodimer interface [polypeptide binding]; other site
86416006183	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
86416006184	GTPase/Zn-binding domain interface [polypeptide binding]; other site
86416006185	GTP/Mg2+ binding site [chemical binding]; other site
86416006186	G4 box; other site
86416006187	G5 box; other site
86416006188	G1 box; other site
86416006189	Switch I region; other site
86416006190	G2 box; other site
86416006191	G3 box; other site
86416006192	Switch II region; other site
86416006193	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
86416006194	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
86416006195	substrate binding site [chemical binding]; other site
86416006196	hexamer interface [polypeptide binding]; other site
86416006197	metal binding site [ion binding]; metal-binding site
86416006198	Thiamine pyrophosphokinase; Region: TPK; cd07995
86416006199	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
86416006200	active site
86416006201	dimerization interface [polypeptide binding]; other site
86416006202	thiamine binding site [chemical binding]; other site
86416006203	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
86416006204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
86416006205	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
86416006206	DAK2 domain; Region: Dak2; pfam02734
86416006207	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
86416006208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416006209	ATP binding site [chemical binding]; other site
86416006210	putative Mg++ binding site [ion binding]; other site
86416006211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416006212	nucleotide binding region [chemical binding]; other site
86416006213	ATP-binding site [chemical binding]; other site
86416006214	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
86416006215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416006216	S-adenosylmethionine binding site [chemical binding]; other site
86416006217	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
86416006218	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
86416006219	active site
86416006220	(T/H)XGH motif; other site
86416006221	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
86416006222	Nucleoside recognition; Region: Gate; pfam07670
86416006223	hypothetical protein; Provisional; Region: PRK13670
86416006224	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
86416006225	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
86416006226	propionate/acetate kinase; Provisional; Region: PRK12379
86416006227	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416006228	nucleotide binding site [chemical binding]; other site
86416006229	butyrate kinase; Provisional; Region: PRK03011
86416006230	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
86416006231	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
86416006232	putative phosphate acyltransferase; Provisional; Region: PRK05331
86416006233	acyl carrier protein; Provisional; Region: acpP; PRK00982
86416006234	ribonuclease III; Reviewed; Region: rnc; PRK00102
86416006235	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
86416006236	dimerization interface [polypeptide binding]; other site
86416006237	active site
86416006238	metal binding site [ion binding]; metal-binding site
86416006239	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
86416006240	dsRNA binding site [nucleotide binding]; other site
86416006241	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
86416006242	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416006243	FeS/SAM binding site; other site
86416006244	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
86416006245	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
86416006246	Walker A/P-loop; other site
86416006247	ATP binding site [chemical binding]; other site
86416006248	Q-loop/lid; other site
86416006249	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
86416006250	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
86416006251	ABC transporter signature motif; other site
86416006252	Walker B; other site
86416006253	D-loop; other site
86416006254	H-loop/switch region; other site
86416006255	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
86416006256	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
86416006257	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416006258	putative DNA-binding protein; Validated; Region: PRK00118
86416006259	signal recognition particle protein; Provisional; Region: PRK10867
86416006260	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
86416006261	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
86416006262	P loop; other site
86416006263	GTP binding site [chemical binding]; other site
86416006264	Signal peptide binding domain; Region: SRP_SPB; pfam02978
86416006265	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
86416006266	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
86416006267	hypothetical protein; Provisional; Region: PRK00468
86416006268	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
86416006269	RimM N-terminal domain; Region: RimM; pfam01782
86416006270	PRC-barrel domain; Region: PRC; pfam05239
86416006271	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
86416006272	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
86416006273	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
86416006274	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
86416006275	Catalytic site [active]
86416006276	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
86416006277	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
86416006278	GTP/Mg2+ binding site [chemical binding]; other site
86416006279	G4 box; other site
86416006280	G5 box; other site
86416006281	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
86416006282	G1 box; other site
86416006283	G1 box; other site
86416006284	GTP/Mg2+ binding site [chemical binding]; other site
86416006285	Switch I region; other site
86416006286	G2 box; other site
86416006287	G2 box; other site
86416006288	G3 box; other site
86416006289	G3 box; other site
86416006290	Switch II region; other site
86416006291	Switch II region; other site
86416006292	G4 box; other site
86416006293	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
86416006294	RNA/DNA hybrid binding site [nucleotide binding]; other site
86416006295	active site
86416006296	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
86416006297	NlpC/P60 family; Region: NLPC_P60; pfam00877
86416006298	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416006299	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416006300	NodB motif; other site
86416006301	active site
86416006302	catalytic site [active]
86416006303	Zn binding site [ion binding]; other site
86416006304	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
86416006305	DNA-binding site [nucleotide binding]; DNA binding site
86416006306	RNA-binding motif; other site
86416006307	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
86416006308	active site
86416006309	Shikimate kinase; Region: SKI; pfam01202
86416006310	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
86416006311	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
86416006312	catalytic residues [active]
86416006313	catalytic nucleophile [active]
86416006314	Recombinase; Region: Recombinase; pfam07508
86416006315	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
86416006316	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
86416006317	Accessory gene regulator B; Region: AgrB; pfam04647
86416006318	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
86416006319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416006320	ATP binding site [chemical binding]; other site
86416006321	Mg2+ binding site [ion binding]; other site
86416006322	G-X-G motif; other site
86416006323	Staphylococcal AgrD protein; Region: AgrD; cl05477
86416006324	Ion transport protein; Region: Ion_trans; pfam00520
86416006325	Ion channel; Region: Ion_trans_2; pfam07885
86416006326	Domain of unknown function (DUF955); Region: DUF955; cl01076
86416006327	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416006328	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416006329	non-specific DNA binding site [nucleotide binding]; other site
86416006330	salt bridge; other site
86416006331	sequence-specific DNA binding site [nucleotide binding]; other site
86416006332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416006333	non-specific DNA binding site [nucleotide binding]; other site
86416006334	salt bridge; other site
86416006335	sequence-specific DNA binding site [nucleotide binding]; other site
86416006336	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
86416006337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416006338	AAA domain; Region: AAA_23; pfam13476
86416006339	Walker A/P-loop; other site
86416006340	ATP binding site [chemical binding]; other site
86416006341	Q-loop/lid; other site
86416006342	Protein of unknown function (DUF1633); Region: DUF1633; pfam07794
86416006343	RecT family; Region: RecT; pfam03837
86416006344	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
86416006345	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
86416006346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
86416006347	Walker A motif; other site
86416006348	ATP binding site [chemical binding]; other site
86416006349	Walker B motif; other site
86416006350	arginine finger; other site
86416006351	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
86416006352	Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921
86416006353	HNH endonuclease; Region: HNH_3; pfam13392
86416006354	AP2 domain; Region: AP2; pfam00847
86416006355	DNA polymerase II large subunit; Validated; Region: PRK04023
86416006356	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416006357	aspartate racemase; Region: asp_race; TIGR00035
86416006358	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
86416006359	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
86416006360	Phage terminase small subunit; Region: Phage_terminase; pfam10668
86416006361	Terminase small subunit; Region: Terminase_2; pfam03592
86416006362	Phage terminase large subunit; Region: Terminase_3; cl12054
86416006363	Terminase-like family; Region: Terminase_6; pfam03237
86416006364	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
86416006365	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
86416006366	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
86416006367	YjzC-like protein; Region: YjzC; pfam14168
86416006368	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
86416006369	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
86416006370	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
86416006371	Phage-related protein [Function unknown]; Region: COG5412
86416006372	Phage-related protein [Function unknown]; Region: COG5412
86416006373	Phage tail protein; Region: Sipho_tail; cl17486
86416006374	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
86416006375	active site
86416006376	catalytic triad [active]
86416006377	oxyanion hole [active]
86416006378	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
86416006379	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
86416006380	active site
86416006381	catalytic residues [active]
86416006382	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416006383	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
86416006384	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416006385	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416006386	active site
86416006387	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416006388	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416006389	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416006390	Coat F domain; Region: Coat_F; pfam07875
86416006391	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
86416006392	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416006393	non-specific DNA binding site [nucleotide binding]; other site
86416006394	salt bridge; other site
86416006395	sequence-specific DNA binding site [nucleotide binding]; other site
86416006396	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
86416006397	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
86416006398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416006399	Walker A motif; other site
86416006400	ATP binding site [chemical binding]; other site
86416006401	Walker B motif; other site
86416006402	hypothetical protein; Reviewed; Region: PRK12497
86416006403	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
86416006404	DNA protecting protein DprA; Region: dprA; TIGR00732
86416006405	DNA topoisomerase I; Validated; Region: PRK05582
86416006406	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
86416006407	active site
86416006408	interdomain interaction site; other site
86416006409	putative metal-binding site [ion binding]; other site
86416006410	nucleotide binding site [chemical binding]; other site
86416006411	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
86416006412	domain I; other site
86416006413	DNA binding groove [nucleotide binding]
86416006414	phosphate binding site [ion binding]; other site
86416006415	domain II; other site
86416006416	domain III; other site
86416006417	nucleotide binding site [chemical binding]; other site
86416006418	catalytic site [active]
86416006419	domain IV; other site
86416006420	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
86416006421	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
86416006422	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
86416006423	transcriptional repressor CodY; Validated; Region: PRK04158
86416006424	CodY GAF-like domain; Region: CodY; pfam06018
86416006425	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
86416006426	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
86416006427	rRNA interaction site [nucleotide binding]; other site
86416006428	S8 interaction site; other site
86416006429	putative laminin-1 binding site; other site
86416006430	elongation factor Ts; Provisional; Region: tsf; PRK09377
86416006431	UBA/TS-N domain; Region: UBA; pfam00627
86416006432	Elongation factor TS; Region: EF_TS; pfam00889
86416006433	Elongation factor TS; Region: EF_TS; pfam00889
86416006434	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
86416006435	putative nucleotide binding site [chemical binding]; other site
86416006436	uridine monophosphate binding site [chemical binding]; other site
86416006437	homohexameric interface [polypeptide binding]; other site
86416006438	ribosome recycling factor; Reviewed; Region: frr; PRK00083
86416006439	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
86416006440	hinge region; other site
86416006441	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
86416006442	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
86416006443	catalytic residue [active]
86416006444	putative FPP diphosphate  binding site; other site
86416006445	putative FPP binding hydrophobic cleft; other site
86416006446	dimer interface [polypeptide binding]; other site
86416006447	putative IPP diphosphate binding site; other site
86416006448	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
86416006449	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
86416006450	Domain of unknown function DUF20; Region: UPF0118; pfam01594
86416006451	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
86416006452	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
86416006453	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
86416006454	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
86416006455	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
86416006456	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
86416006457	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
86416006458	active site
86416006459	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
86416006460	protein binding site [polypeptide binding]; other site
86416006461	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
86416006462	putative substrate binding region [chemical binding]; other site
86416006463	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
86416006464	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
86416006465	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
86416006466	ribosome maturation protein RimP; Reviewed; Region: PRK00092
86416006467	Sm and related proteins; Region: Sm_like; cl00259
86416006468	heptamer interface [polypeptide binding]; other site
86416006469	Sm1 motif; other site
86416006470	hexamer interface [polypeptide binding]; other site
86416006471	RNA binding site [nucleotide binding]; other site
86416006472	Sm2 motif; other site
86416006473	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
86416006474	NusA N-terminal domain; Region: NusA_N; pfam08529
86416006475	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
86416006476	RNA binding site [nucleotide binding]; other site
86416006477	homodimer interface [polypeptide binding]; other site
86416006478	NusA-like KH domain; Region: KH_5; pfam13184
86416006479	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
86416006480	G-X-X-G motif; other site
86416006481	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
86416006482	putative RNA binding cleft [nucleotide binding]; other site
86416006483	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
86416006484	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
86416006485	translation initiation factor IF-2; Region: IF-2; TIGR00487
86416006486	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
86416006487	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
86416006488	G1 box; other site
86416006489	putative GEF interaction site [polypeptide binding]; other site
86416006490	GTP/Mg2+ binding site [chemical binding]; other site
86416006491	Switch I region; other site
86416006492	G2 box; other site
86416006493	G3 box; other site
86416006494	Switch II region; other site
86416006495	G4 box; other site
86416006496	G5 box; other site
86416006497	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
86416006498	Translation-initiation factor 2; Region: IF-2; pfam11987
86416006499	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
86416006500	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
86416006501	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
86416006502	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
86416006503	RNA binding site [nucleotide binding]; other site
86416006504	active site
86416006505	riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083
86416006506	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
86416006507	active site
86416006508	Riboflavin kinase; Region: Flavokinase; pfam01687
86416006509	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
86416006510	16S/18S rRNA binding site [nucleotide binding]; other site
86416006511	S13e-L30e interaction site [polypeptide binding]; other site
86416006512	25S rRNA binding site [nucleotide binding]; other site
86416006513	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
86416006514	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
86416006515	RNase E interface [polypeptide binding]; other site
86416006516	trimer interface [polypeptide binding]; other site
86416006517	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
86416006518	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
86416006519	RNase E interface [polypeptide binding]; other site
86416006520	trimer interface [polypeptide binding]; other site
86416006521	active site
86416006522	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
86416006523	putative nucleic acid binding region [nucleotide binding]; other site
86416006524	G-X-X-G motif; other site
86416006525	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
86416006526	RNA binding site [nucleotide binding]; other site
86416006527	domain interface; other site
86416006528	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
86416006529	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
86416006530	Clp protease; Region: CLP_protease; pfam00574
86416006531	active site
86416006532	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
86416006533	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
86416006534	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
86416006535	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
86416006536	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
86416006537	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
86416006538	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416006539	FeS/SAM binding site; other site
86416006540	TRAM domain; Region: TRAM; cl01282
86416006541	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
86416006542	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
86416006543	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
86416006544	hexamer interface [polypeptide binding]; other site
86416006545	Walker A motif; other site
86416006546	ATP binding site [chemical binding]; other site
86416006547	Walker B motif; other site
86416006548	phosphodiesterase; Provisional; Region: PRK12704
86416006549	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
86416006550	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416006551	Zn2+ binding site [ion binding]; other site
86416006552	Mg2+ binding site [ion binding]; other site
86416006553	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
86416006554	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
86416006555	aspartate aminotransferase; Provisional; Region: PRK05764
86416006556	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416006557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416006558	homodimer interface [polypeptide binding]; other site
86416006559	catalytic residue [active]
86416006560	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
86416006561	dimerization domain swap beta strand [polypeptide binding]; other site
86416006562	regulatory protein interface [polypeptide binding]; other site
86416006563	active site
86416006564	regulatory phosphorylation site [posttranslational modification]; other site
86416006565	Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353
86416006566	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
86416006567	active site
86416006568	catalytic site [active]
86416006569	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
86416006570	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
86416006571	tetramer interface [polypeptide binding]; other site
86416006572	active site
86416006573	short chain dehydrogenase; Provisional; Region: PRK06701
86416006574	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
86416006575	NAD binding site [chemical binding]; other site
86416006576	metal binding site [ion binding]; metal-binding site
86416006577	active site
86416006578	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
86416006579	FMN binding site [chemical binding]; other site
86416006580	dimer interface [polypeptide binding]; other site
86416006581	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416006582	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416006583	metal-binding site [ion binding]
86416006584	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416006585	Soluble P-type ATPase [General function prediction only]; Region: COG4087
86416006586	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
86416006587	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416006588	substrate binding pocket [chemical binding]; other site
86416006589	membrane-bound complex binding site; other site
86416006590	hinge residues; other site
86416006591	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416006592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416006593	dimer interface [polypeptide binding]; other site
86416006594	conserved gate region; other site
86416006595	putative PBP binding loops; other site
86416006596	ABC-ATPase subunit interface; other site
86416006597	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
86416006598	DEAD-like helicases superfamily; Region: DEXDc; smart00487
86416006599	ATP binding site [chemical binding]; other site
86416006600	Mg++ binding site [ion binding]; other site
86416006601	motif III; other site
86416006602	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416006603	nucleotide binding region [chemical binding]; other site
86416006604	ATP-binding site [chemical binding]; other site
86416006605	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
86416006606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416006607	ATP binding site [chemical binding]; other site
86416006608	putative Mg++ binding site [ion binding]; other site
86416006609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416006610	nucleotide binding region [chemical binding]; other site
86416006611	ATP-binding site [chemical binding]; other site
86416006612	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
86416006613	HRDC domain; Region: HRDC; pfam00570
86416006614	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
86416006615	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
86416006616	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
86416006617	putative transporter; Provisional; Region: PRK11660
86416006618	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
86416006619	Sulfate transporter family; Region: Sulfate_transp; pfam00916
86416006620	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
86416006621	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416006622	MarR family; Region: MarR_2; pfam12802
86416006623	Transcriptional regulators [Transcription]; Region: MarR; COG1846
86416006624	MarR family; Region: MarR; pfam01047
86416006625	putative hydrolase; Validated; Region: PRK09248
86416006626	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
86416006627	active site
86416006628	Protease prsW family; Region: PrsW-protease; pfam13367
86416006629	Domain of unknown function (DUF370); Region: DUF370; cl00898
86416006630	Accessory gene regulator B; Region: AgrB; pfam04647
86416006631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416006632	ATP binding site [chemical binding]; other site
86416006633	Mg2+ binding site [ion binding]; other site
86416006634	G-X-G motif; other site
86416006635	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
86416006636	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416006637	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416006638	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
86416006639	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
86416006640	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
86416006641	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416006642	ATP binding site [chemical binding]; other site
86416006643	putative Mg++ binding site [ion binding]; other site
86416006644	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416006645	nucleotide binding region [chemical binding]; other site
86416006646	ATP-binding site [chemical binding]; other site
86416006647	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
86416006648	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
86416006649	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
86416006650	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
86416006651	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416006652	active site
86416006653	DNA binding site [nucleotide binding]
86416006654	Int/Topo IB signature motif; other site
86416006655	Uncharacterized conserved protein [Function unknown]; Region: COG1434
86416006656	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
86416006657	putative active site [active]
86416006658	GtrA-like protein; Region: GtrA; pfam04138
86416006659	Predicted membrane protein [Function unknown]; Region: COG2246
86416006660	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
86416006661	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
86416006662	catalytic residue [active]
86416006663	putative FPP diphosphate  binding site; other site
86416006664	putative FPP binding hydrophobic cleft; other site
86416006665	dimer interface [polypeptide binding]; other site
86416006666	putative IPP diphosphate binding site; other site
86416006667	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416006668	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
86416006669	DNA binding residues [nucleotide binding]
86416006670	drug binding residues [chemical binding]; other site
86416006671	dimer interface [polypeptide binding]; other site
86416006672	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
86416006673	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
86416006674	active site
86416006675	catalytic triad [active]
86416006676	oxyanion hole [active]
86416006677	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
86416006678	stage II sporulation protein P; Region: spore_II_P; TIGR02867
86416006679	LexA repressor; Validated; Region: PRK00215
86416006680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416006681	putative DNA binding site [nucleotide binding]; other site
86416006682	putative Zn2+ binding site [ion binding]; other site
86416006683	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
86416006684	Catalytic site [active]
86416006685	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
86416006686	Aluminium resistance protein; Region: Alum_res; pfam06838
86416006687	bacterial Hfq-like; Region: Hfq; cd01716
86416006688	hexamer interface [polypeptide binding]; other site
86416006689	Sm1 motif; other site
86416006690	RNA binding site [nucleotide binding]; other site
86416006691	Sm2 motif; other site
86416006692	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
86416006693	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
86416006694	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
86416006695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
86416006696	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
86416006697	ATP binding site [chemical binding]; other site
86416006698	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
86416006699	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
86416006700	MutS domain I; Region: MutS_I; pfam01624
86416006701	MutS domain II; Region: MutS_II; pfam05188
86416006702	MutS domain III; Region: MutS_III; pfam05192
86416006703	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
86416006704	Walker A/P-loop; other site
86416006705	ATP binding site [chemical binding]; other site
86416006706	Q-loop/lid; other site
86416006707	ABC transporter signature motif; other site
86416006708	Walker B; other site
86416006709	D-loop; other site
86416006710	H-loop/switch region; other site
86416006711	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
86416006712	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
86416006713	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416006714	FeS/SAM binding site; other site
86416006715	TRAM domain; Region: TRAM; pfam01938
86416006716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416006717	Coenzyme A binding pocket [chemical binding]; other site
86416006718	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
86416006719	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
86416006720	LytB protein; Region: LYTB; cl00507
86416006721	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
86416006722	RNA binding site [nucleotide binding]; other site
86416006723	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
86416006724	RNA binding site [nucleotide binding]; other site
86416006725	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
86416006726	RNA binding site [nucleotide binding]; other site
86416006727	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
86416006728	RNA binding site [nucleotide binding]; other site
86416006729	cytidylate kinase; Provisional; Region: cmk; PRK00023
86416006730	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
86416006731	CMP-binding site; other site
86416006732	The sites determining sugar specificity; other site
86416006733	HI0933-like protein; Region: HI0933_like; pfam03486
86416006734	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416006735	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416006736	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416006737	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416006738	putative active site [active]
86416006739	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
86416006740	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416006741	RNA binding surface [nucleotide binding]; other site
86416006742	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
86416006743	active site
86416006744	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
86416006745	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
86416006746	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416006747	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416006748	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416006749	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416006750	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
86416006751	hypothetical protein; Provisional; Region: PRK05802
86416006752	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
86416006753	FAD binding pocket [chemical binding]; other site
86416006754	FAD binding motif [chemical binding]; other site
86416006755	phosphate binding motif [ion binding]; other site
86416006756	beta-alpha-beta structure motif; other site
86416006757	NAD binding pocket [chemical binding]; other site
86416006758	Iron coordination center [ion binding]; other site
86416006759	Glucose inhibited division protein A; Region: GIDA; pfam01134
86416006760	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
86416006761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416006762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416006763	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
86416006764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
86416006765	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416006766	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416006767	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416006768	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416006769	4Fe-4S binding domain; Region: Fer4; pfam00037
86416006770	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
86416006771	putative FMN binding site [chemical binding]; other site
86416006772	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
86416006773	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
86416006774	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416006775	putative active site [active]
86416006776	putative NTP binding site [chemical binding]; other site
86416006777	putative nucleic acid binding site [nucleotide binding]; other site
86416006778	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416006779	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
86416006780	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416006781	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
86416006782	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
86416006783	nudix motif; other site
86416006784	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416006785	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416006786	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416006787	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416006788	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416006789	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416006790	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
86416006791	putative FMN binding site [chemical binding]; other site
86416006792	putative transposase OrfB; Reviewed; Region: PHA02517
86416006793	HTH-like domain; Region: HTH_21; pfam13276
86416006794	Integrase core domain; Region: rve; pfam00665
86416006795	Integrase core domain; Region: rve_3; pfam13683
86416006796	Transposase; Region: HTH_Tnp_1; pfam01527
86416006797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
86416006798	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
86416006799	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416006800	active site
86416006801	catalytic tetrad [active]
86416006802	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416006803	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416006804	DNA binding residues [nucleotide binding]
86416006805	putative dimer interface [polypeptide binding]; other site
86416006806	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
86416006807	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416006808	active site
86416006809	catalytic tetrad [active]
86416006810	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
86416006811	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
86416006812	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416006813	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416006814	active site
86416006815	catalytic tetrad [active]
86416006816	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
86416006817	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
86416006818	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
86416006819	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
86416006820	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
86416006821	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
86416006822	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
86416006823	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
86416006824	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
86416006825	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
86416006826	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
86416006827	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
86416006828	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
86416006829	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
86416006830	purine nucleoside phosphorylase; Provisional; Region: PRK08202
86416006831	purine nucleoside phosphorylase; Provisional; Region: PRK08202
86416006832	phosphopentomutase; Provisional; Region: PRK05362
86416006833	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
86416006834	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
86416006835	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
86416006836	active site
86416006837	Int/Topo IB signature motif; other site
86416006838	stage II sporulation protein M; Region: spo_II_M; TIGR02831
86416006839	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
86416006840	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
86416006841	dimer interface [polypeptide binding]; other site
86416006842	ADP-ribose binding site [chemical binding]; other site
86416006843	active site
86416006844	nudix motif; other site
86416006845	metal binding site [ion binding]; metal-binding site
86416006846	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
86416006847	Predicted membrane protein [Function unknown]; Region: COG2323
86416006848	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
86416006849	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
86416006850	EamA-like transporter family; Region: EamA; pfam00892
86416006851	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416006852	Phage terminase, small subunit; Region: Terminase_4; cl01525
86416006853	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
86416006854	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
86416006855	Transposase; Region: HTH_Tnp_1; pfam01527
86416006856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
86416006857	putative transposase OrfB; Reviewed; Region: PHA02517
86416006858	HTH-like domain; Region: HTH_21; pfam13276
86416006859	Integrase core domain; Region: rve; pfam00665
86416006860	Integrase core domain; Region: rve_3; pfam13683
86416006861	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
86416006862	Helix-turn-helix domain; Region: HTH_36; pfam13730
86416006863	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416006864	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
86416006865	active site
86416006866	DNA binding site [nucleotide binding]
86416006867	Int/Topo IB signature motif; other site
86416006868	Spore germination protein; Region: Spore_permease; cl17796
86416006869	Bacteriophage holin; Region: Phage_holin_1; cl02344
86416006870	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416006871	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416006872	active site
86416006873	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416006874	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416006875	Haemolysin XhlA; Region: XhlA; pfam10779
86416006876	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
86416006877	Right handed beta helix region; Region: Beta_helix; pfam13229
86416006878	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
86416006879	Phage-related protein [Function unknown]; Region: COG5412
86416006880	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
86416006881	Phage-related minor tail protein [Function unknown]; Region: COG5281
86416006882	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
86416006883	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
86416006884	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
86416006885	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
86416006886	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
86416006887	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
86416006888	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
86416006889	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
86416006890	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
86416006891	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
86416006892	active site
86416006893	catalytic site [active]
86416006894	metal binding site [ion binding]; metal-binding site
86416006895	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
86416006896	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
86416006897	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
86416006898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
86416006899	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
86416006900	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416006901	Phage integrase family; Region: Phage_integrase; pfam00589
86416006902	active site
86416006903	Int/Topo IB signature motif; other site
86416006904	DNA binding site [nucleotide binding]
86416006905	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
86416006906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416006907	active site
86416006908	phosphorylation site [posttranslational modification]
86416006909	intermolecular recognition site; other site
86416006910	dimerization interface [polypeptide binding]; other site
86416006911	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
86416006912	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
86416006913	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
86416006914	protein binding site [polypeptide binding]; other site
86416006915	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
86416006916	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
86416006917	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
86416006918	Walker A/P-loop; other site
86416006919	ATP binding site [chemical binding]; other site
86416006920	Q-loop/lid; other site
86416006921	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
86416006922	ABC transporter signature motif; other site
86416006923	Walker B; other site
86416006924	D-loop; other site
86416006925	H-loop/switch region; other site
86416006926	arginine repressor; Provisional; Region: argR; PRK00441
86416006927	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
86416006928	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
86416006929	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
86416006930	ATP-NAD kinase; Region: NAD_kinase; pfam01513
86416006931	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
86416006932	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416006933	RNA binding surface [nucleotide binding]; other site
86416006934	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
86416006935	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
86416006936	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
86416006937	TPP-binding site; other site
86416006938	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
86416006939	PYR/PP interface [polypeptide binding]; other site
86416006940	dimer interface [polypeptide binding]; other site
86416006941	TPP binding site [chemical binding]; other site
86416006942	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416006943	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
86416006944	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
86416006945	substrate binding pocket [chemical binding]; other site
86416006946	chain length determination region; other site
86416006947	substrate-Mg2+ binding site; other site
86416006948	catalytic residues [active]
86416006949	aspartate-rich region 1; other site
86416006950	active site lid residues [active]
86416006951	aspartate-rich region 2; other site
86416006952	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
86416006953	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
86416006954	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
86416006955	generic binding surface I; other site
86416006956	generic binding surface II; other site
86416006957	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
86416006958	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172
86416006959	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
86416006960	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
86416006961	homodimer interface [polypeptide binding]; other site
86416006962	NADP binding site [chemical binding]; other site
86416006963	substrate binding site [chemical binding]; other site
86416006964	transcription antitermination factor NusB; Region: nusB; TIGR01951
86416006965	putative RNA binding site [nucleotide binding]; other site
86416006966	Asp23 family; Region: Asp23; pfam03780
86416006967	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
86416006968	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
86416006969	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
86416006970	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
86416006971	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
86416006972	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
86416006973	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
86416006974	elongation factor P; Validated; Region: PRK00529
86416006975	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
86416006976	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
86416006977	RNA binding site [nucleotide binding]; other site
86416006978	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
86416006979	RNA binding site [nucleotide binding]; other site
86416006980	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
86416006981	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
86416006982	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
86416006983	active site
86416006984	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
86416006985	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
86416006986	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
86416006987	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
86416006988	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
86416006989	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
86416006990	active site
86416006991	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
86416006992	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
86416006993	catalytic residue [active]
86416006994	putative FPP diphosphate  binding site; other site
86416006995	putative FPP binding hydrophobic cleft; other site
86416006996	dimer interface [polypeptide binding]; other site
86416006997	putative IPP diphosphate binding site; other site
86416006998	PemK-like protein; Region: PemK; pfam02452
86416006999	P63C domain; Region: P63C; pfam10546
86416007000	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
86416007001	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416007002	active site
86416007003	DNA binding site [nucleotide binding]
86416007004	Int/Topo IB signature motif; other site
86416007005	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
86416007006	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
86416007007	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416007008	active site
86416007009	DNA binding site [nucleotide binding]
86416007010	Int/Topo IB signature motif; other site
86416007011	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
86416007012	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
86416007013	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
86416007014	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
86416007015	Walker A motif; other site
86416007016	ATP binding site [chemical binding]; other site
86416007017	Walker B motif; other site
86416007018	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
86416007019	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
86416007020	dimer interface [polypeptide binding]; other site
86416007021	active site
86416007022	metal binding site [ion binding]; metal-binding site
86416007023	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
86416007024	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
86416007025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007026	catalytic residue [active]
86416007027	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
86416007028	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
86416007029	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
86416007030	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
86416007031	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
86416007032	glutamine binding [chemical binding]; other site
86416007033	catalytic triad [active]
86416007034	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
86416007035	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
86416007036	Domain of unknown function (DUF814); Region: DUF814; pfam05670
86416007037	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
86416007038	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
86416007039	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
86416007040	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416007041	RNA binding surface [nucleotide binding]; other site
86416007042	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
86416007043	active site
86416007044	lipoprotein signal peptidase; Provisional; Region: PRK14791
86416007045	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
86416007046	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
86416007047	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
86416007048	DivIVA protein; Region: DivIVA; pfam05103
86416007049	DivIVA domain; Region: DivI1A_domain; TIGR03544
86416007050	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
86416007051	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416007052	RNA binding surface [nucleotide binding]; other site
86416007053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
86416007054	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
86416007055	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
86416007056	catalytic residue [active]
86416007057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
86416007058	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
86416007059	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
86416007060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
86416007061	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
86416007062	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
86416007063	Cell division protein FtsQ; Region: FtsQ; pfam03799
86416007064	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
86416007065	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
86416007066	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
86416007067	Mg++ binding site [ion binding]; other site
86416007068	putative catalytic motif [active]
86416007069	putative substrate binding site [chemical binding]; other site
86416007070	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
86416007071	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
86416007072	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
86416007073	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
86416007074	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
86416007075	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
86416007076	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
86416007077	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
86416007078	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
86416007079	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416007080	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
86416007081	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
86416007082	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
86416007083	MraW methylase family; Region: Methyltransf_5; pfam01795
86416007084	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
86416007085	cell division protein MraZ; Reviewed; Region: PRK00326
86416007086	MraZ protein; Region: MraZ; pfam02381
86416007087	MraZ protein; Region: MraZ; pfam02381
86416007088	GTP-binding protein YchF; Reviewed; Region: PRK09601
86416007089	YchF GTPase; Region: YchF; cd01900
86416007090	G1 box; other site
86416007091	GTP/Mg2+ binding site [chemical binding]; other site
86416007092	Switch I region; other site
86416007093	G2 box; other site
86416007094	Switch II region; other site
86416007095	G3 box; other site
86416007096	G4 box; other site
86416007097	G5 box; other site
86416007098	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
86416007099	Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404
86416007100	active site
86416007101	AAA domain; Region: AAA_32; pfam13654
86416007102	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
86416007103	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
86416007104	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
86416007105	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
86416007106	active site
86416007107	Zn binding site [ion binding]; other site
86416007108	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
86416007109	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
86416007110	active site
86416007111	Zn binding site [ion binding]; other site
86416007112	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
86416007113	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
86416007114	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
86416007115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
86416007116	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
86416007117	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416007118	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
86416007119	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416007120	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416007121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416007122	motif II; other site
86416007123	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416007124	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
86416007125	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
86416007126	DRTGG domain; Region: DRTGG; pfam07085
86416007127	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
86416007128	DHHA2 domain; Region: DHHA2; pfam02833
86416007129	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817
86416007130	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
86416007131	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
86416007132	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
86416007133	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
86416007134	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
86416007135	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
86416007136	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416007137	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
86416007138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416007139	DNA binding residues [nucleotide binding]
86416007140	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
86416007141	Flagellar protein YcgR; Region: YcgR_2; pfam12945
86416007142	PilZ domain; Region: PilZ; pfam07238
86416007143	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
86416007144	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
86416007145	P-loop; other site
86416007146	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
86416007147	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416007148	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
86416007149	FHIPEP family; Region: FHIPEP; pfam00771
86416007150	bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772
86416007151	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
86416007152	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
86416007153	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
86416007154	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
86416007155	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
86416007156	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
86416007157	Flagellar protein (FlbD); Region: FlbD; pfam06289
86416007158	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
86416007159	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
86416007160	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
86416007161	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
86416007162	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
86416007163	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
86416007164	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
86416007165	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
86416007166	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
86416007167	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
86416007168	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
86416007169	Walker A motif/ATP binding site; other site
86416007170	Walker B motif; other site
86416007171	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
86416007172	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
86416007173	FliG C-terminal domain; Region: FliG_C; pfam01706
86416007174	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
86416007175	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
86416007176	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
86416007177	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
86416007178	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630
86416007179	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
86416007180	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
86416007181	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623
86416007182	flagellin; Provisional; Region: PRK12804
86416007183	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
86416007184	flagellin; Provisional; Region: PRK12804
86416007185	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
86416007186	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
86416007187	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
86416007188	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
86416007189	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416007190	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
86416007191	active site
86416007192	Putative motility protein; Region: YjfB_motility; pfam14070
86416007193	flagellin; Reviewed; Region: PRK08869
86416007194	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
86416007195	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
86416007196	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
86416007197	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
86416007198	Flagellar protein FliS; Region: FliS; cl00654
86416007199	FlaG protein; Region: FlaG; pfam03646
86416007200	Global regulator protein family; Region: CsrA; pfam02599
86416007201	flagellar assembly protein FliW; Provisional; Region: PRK13285
86416007202	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
86416007203	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
86416007204	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
86416007205	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
86416007206	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
86416007207	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
86416007208	FlgN protein; Region: FlgN; pfam05130
86416007209	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
86416007210	flagellar motor switch protein; Validated; Region: PRK08119
86416007211	CheC-like family; Region: CheC; pfam04509
86416007212	CheC-like family; Region: CheC; pfam04509
86416007213	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
86416007214	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
86416007215	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
86416007216	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
86416007217	Response regulator receiver domain; Region: Response_reg; pfam00072
86416007218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416007219	active site
86416007220	phosphorylation site [posttranslational modification]
86416007221	intermolecular recognition site; other site
86416007222	dimerization interface [polypeptide binding]; other site
86416007223	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
86416007224	CheC-like family; Region: CheC; pfam04509
86416007225	CheC-like family; Region: CheC; pfam04509
86416007226	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
86416007227	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
86416007228	putative binding surface; other site
86416007229	active site
86416007230	P2 response regulator binding domain; Region: P2; pfam07194
86416007231	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
86416007232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416007233	ATP binding site [chemical binding]; other site
86416007234	Mg2+ binding site [ion binding]; other site
86416007235	G-X-G motif; other site
86416007236	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
86416007237	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
86416007238	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
86416007239	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
86416007240	Response regulator receiver domain; Region: Response_reg; pfam00072
86416007241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416007242	active site
86416007243	phosphorylation site [posttranslational modification]
86416007244	intermolecular recognition site; other site
86416007245	dimerization interface [polypeptide binding]; other site
86416007246	CheB methylesterase; Region: CheB_methylest; pfam01339
86416007247	CheD chemotactic sensory transduction; Region: CheD; cl00810
86416007248	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
86416007249	CAT RNA binding domain; Region: CAT_RBD; smart01061
86416007250	transcriptional antiterminator BglG; Provisional; Region: PRK09772
86416007251	PRD domain; Region: PRD; pfam00874
86416007252	PRD domain; Region: PRD; pfam00874
86416007253	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
86416007254	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
86416007255	NAD binding site [chemical binding]; other site
86416007256	dimer interface [polypeptide binding]; other site
86416007257	substrate binding site [chemical binding]; other site
86416007258	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416007259	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
86416007260	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
86416007261	homodimer interface [polypeptide binding]; other site
86416007262	substrate-cofactor binding pocket; other site
86416007263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007264	catalytic residue [active]
86416007265	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
86416007266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416007267	motif II; other site
86416007268	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
86416007269	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
86416007270	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
86416007271	dimer interface [polypeptide binding]; other site
86416007272	PYR/PP interface [polypeptide binding]; other site
86416007273	TPP binding site [chemical binding]; other site
86416007274	substrate binding site [chemical binding]; other site
86416007275	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
86416007276	Domain of unknown function; Region: EKR; smart00890
86416007277	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416007278	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
86416007279	TPP-binding site [chemical binding]; other site
86416007280	dimer interface [polypeptide binding]; other site
86416007281	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
86416007282	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
86416007283	dimer interface [polypeptide binding]; other site
86416007284	PYR/PP interface [polypeptide binding]; other site
86416007285	TPP binding site [chemical binding]; other site
86416007286	substrate binding site [chemical binding]; other site
86416007287	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416007288	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
86416007289	Domain of unknown function; Region: EKR; pfam10371
86416007290	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416007291	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
86416007292	TPP-binding site [chemical binding]; other site
86416007293	dimer interface [polypeptide binding]; other site
86416007294	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416007295	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
86416007296	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
86416007297	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
86416007298	Beta-Casp domain; Region: Beta-Casp; smart01027
86416007299	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
86416007300	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
86416007301	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
86416007302	active site
86416007303	homodimer interface [polypeptide binding]; other site
86416007304	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
86416007305	DHH family; Region: DHH; pfam01368
86416007306	DHHA1 domain; Region: DHHA1; pfam02272
86416007307	biotin synthase; Provisional; Region: PRK07094
86416007308	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416007309	FeS/SAM binding site; other site
86416007310	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
86416007311	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
86416007312	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
86416007313	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
86416007314	DJ-1 family protein; Region: not_thiJ; TIGR01383
86416007315	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
86416007316	conserved cys residue [active]
86416007317	DNA topoisomerase IV subunit A; Provisional; Region: PRK13979
86416007318	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
86416007319	CAP-like domain; other site
86416007320	active site
86416007321	primary dimer interface [polypeptide binding]; other site
86416007322	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
86416007323	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
86416007324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416007325	ATP binding site [chemical binding]; other site
86416007326	Mg2+ binding site [ion binding]; other site
86416007327	G-X-G motif; other site
86416007328	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
86416007329	anchoring element; other site
86416007330	dimer interface [polypeptide binding]; other site
86416007331	ATP binding site [chemical binding]; other site
86416007332	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
86416007333	active site
86416007334	metal binding site [ion binding]; metal-binding site
86416007335	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
86416007336	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416007337	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
86416007338	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416007339	active site turn [active]
86416007340	phosphorylation site [posttranslational modification]
86416007341	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416007342	HPr interaction site; other site
86416007343	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416007344	active site
86416007345	phosphorylation site [posttranslational modification]
86416007346	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
86416007347	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
86416007348	predicted active site [active]
86416007349	catalytic triad [active]
86416007350	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
86416007351	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
86416007352	active site
86416007353	multimer interface [polypeptide binding]; other site
86416007354	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416007355	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
86416007356	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416007357	Helix-turn-helix domain; Region: HTH_36; pfam13730
86416007358	hypothetical protein; Validated; Region: PRK00110
86416007359	Uncharacterized conserved protein [Function unknown]; Region: COG1739
86416007360	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
86416007361	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
86416007362	HEAT repeats; Region: HEAT_2; pfam13646
86416007363	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
86416007364	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416007365	DNA-binding site [nucleotide binding]; DNA binding site
86416007366	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
86416007367	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416007368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007369	homodimer interface [polypeptide binding]; other site
86416007370	catalytic residue [active]
86416007371	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
86416007372	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
86416007373	HflX GTPase family; Region: HflX; cd01878
86416007374	G1 box; other site
86416007375	GTP/Mg2+ binding site [chemical binding]; other site
86416007376	Switch I region; other site
86416007377	G2 box; other site
86416007378	G3 box; other site
86416007379	Switch II region; other site
86416007380	G4 box; other site
86416007381	G5 box; other site
86416007382	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
86416007383	Transglycosylase; Region: Transgly; pfam00912
86416007384	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
86416007385	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
86416007386	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
86416007387	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
86416007388	stage V sporulation protein AD; Validated; Region: PRK08304
86416007389	stage V sporulation protein AD; Provisional; Region: PRK12404
86416007390	SpoVA protein; Region: SpoVA; cl04298
86416007391	sporulation sigma factor SigF; Validated; Region: PRK05572
86416007392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416007393	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
86416007394	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416007395	DNA binding residues [nucleotide binding]
86416007396	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
86416007397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416007398	ATP binding site [chemical binding]; other site
86416007399	Mg2+ binding site [ion binding]; other site
86416007400	G-X-G motif; other site
86416007401	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
86416007402	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
86416007403	anti sigma factor interaction site; other site
86416007404	regulatory phosphorylation site [posttranslational modification]; other site
86416007405	spermidine synthase; Provisional; Region: PRK00811
86416007406	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416007407	Methyltransferase domain; Region: Methyltransf_26; pfam13659
86416007408	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
86416007409	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
86416007410	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
86416007411	NodB motif; other site
86416007412	active site
86416007413	catalytic site [active]
86416007414	Cd binding site [ion binding]; other site
86416007415	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
86416007416	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
86416007417	putative FMN binding site [chemical binding]; other site
86416007418	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
86416007419	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
86416007420	Probable Catalytic site; other site
86416007421	metal-binding site
86416007422	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007423	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
86416007424	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
86416007425	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
86416007426	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
86416007427	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
86416007428	NADP binding site [chemical binding]; other site
86416007429	active site
86416007430	putative substrate binding site [chemical binding]; other site
86416007431	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
86416007432	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
86416007433	O-Antigen ligase; Region: Wzy_C; cl04850
86416007434	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
86416007435	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
86416007436	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
86416007437	Probable Catalytic site; other site
86416007438	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
86416007439	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
86416007440	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
86416007441	Probable Catalytic site; other site
86416007442	metal-binding site
86416007443	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
86416007444	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
86416007445	Ligand binding site; other site
86416007446	Putative Catalytic site; other site
86416007447	DXD motif; other site
86416007448	Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404
86416007449	Winged helix-turn helix; Region: HTH_29; pfam13551
86416007450	Homeodomain-like domain; Region: HTH_32; pfam13565
86416007451	Winged helix-turn helix; Region: HTH_33; pfam13592
86416007452	DDE superfamily endonuclease; Region: DDE_3; pfam13358
86416007453	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
86416007454	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
86416007455	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
86416007456	Ligand binding site; other site
86416007457	Putative Catalytic site; other site
86416007458	DXD motif; other site
86416007459	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
86416007460	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416007461	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007462	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
86416007463	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
86416007464	Probable Catalytic site; other site
86416007465	metal-binding site
86416007466	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416007467	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007468	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
86416007469	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
86416007470	Walker A/P-loop; other site
86416007471	ATP binding site [chemical binding]; other site
86416007472	Q-loop/lid; other site
86416007473	ABC transporter signature motif; other site
86416007474	Walker B; other site
86416007475	D-loop; other site
86416007476	H-loop/switch region; other site
86416007477	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
86416007478	putative carbohydrate binding site [chemical binding]; other site
86416007479	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
86416007480	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416007481	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
86416007482	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
86416007483	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
86416007484	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
86416007485	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
86416007486	NAD binding site [chemical binding]; other site
86416007487	substrate binding site [chemical binding]; other site
86416007488	homodimer interface [polypeptide binding]; other site
86416007489	active site
86416007490	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
86416007491	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
86416007492	substrate binding site; other site
86416007493	tetramer interface; other site
86416007494	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
86416007495	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
86416007496	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
86416007497	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
86416007498	active site
86416007499	tetramer interface; other site
86416007500	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
86416007501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
86416007502	binding surface
86416007503	TPR motif; other site
86416007504	Tetratricopeptide repeat; Region: TPR_12; pfam13424
86416007505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416007506	binding surface
86416007507	TPR motif; other site
86416007508	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
86416007509	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
86416007510	active site
86416007511	substrate binding site [chemical binding]; other site
86416007512	metal binding site [ion binding]; metal-binding site
86416007513	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
86416007514	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
86416007515	5S rRNA interface [nucleotide binding]; other site
86416007516	CTC domain interface [polypeptide binding]; other site
86416007517	L16 interface [polypeptide binding]; other site
86416007518	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
86416007519	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
86416007520	homodimer interface [polypeptide binding]; other site
86416007521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007522	catalytic residue [active]
86416007523	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
86416007524	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
86416007525	MutS domain III; Region: MutS_III; pfam05192
86416007526	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
86416007527	Walker A/P-loop; other site
86416007528	ATP binding site [chemical binding]; other site
86416007529	Q-loop/lid; other site
86416007530	ABC transporter signature motif; other site
86416007531	Walker B; other site
86416007532	D-loop; other site
86416007533	H-loop/switch region; other site
86416007534	Smr domain; Region: Smr; pfam01713
86416007535	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
86416007536	Peptidase family U32; Region: Peptidase_U32; pfam01136
86416007537	Collagenase; Region: DUF3656; pfam12392
86416007538	Peptidase family U32; Region: Peptidase_U32; cl03113
86416007539	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
86416007540	chromosome segregation protein; Provisional; Region: PRK03918
86416007541	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
86416007542	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
86416007543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416007544	catalytic residue [active]
86416007545	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
86416007546	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
86416007547	active site
86416007548	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
86416007549	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
86416007550	active site
86416007551	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
86416007552	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007553	putative ADP-binding pocket [chemical binding]; other site
86416007554	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416007555	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
86416007556	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
86416007557	putative ADP-binding pocket [chemical binding]; other site
86416007558	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007559	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
86416007560	putative ADP-binding pocket [chemical binding]; other site
86416007561	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
86416007562	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
86416007563	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
86416007564	NAD binding site [chemical binding]; other site
86416007565	homotetramer interface [polypeptide binding]; other site
86416007566	homodimer interface [polypeptide binding]; other site
86416007567	substrate binding site [chemical binding]; other site
86416007568	active site
86416007569	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
86416007570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416007571	NAD(P) binding site [chemical binding]; other site
86416007572	active site
86416007573	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
86416007574	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
86416007575	active site
86416007576	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
86416007577	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
86416007578	transposase/IS protein; Provisional; Region: PRK09183
86416007579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416007580	Walker A motif; other site
86416007581	ATP binding site [chemical binding]; other site
86416007582	Walker B motif; other site
86416007583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
86416007584	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
86416007585	Integrase core domain; Region: rve; pfam00665
86416007586	Cell division protein ZapA; Region: ZapA; pfam05164
86416007587	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
86416007588	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
86416007589	putative tRNA-binding site [nucleotide binding]; other site
86416007590	B3/4 domain; Region: B3_4; pfam03483
86416007591	tRNA synthetase B5 domain; Region: B5; smart00874
86416007592	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
86416007593	dimer interface [polypeptide binding]; other site
86416007594	motif 1; other site
86416007595	motif 3; other site
86416007596	motif 2; other site
86416007597	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
86416007598	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
86416007599	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
86416007600	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
86416007601	dimer interface [polypeptide binding]; other site
86416007602	motif 1; other site
86416007603	active site
86416007604	motif 2; other site
86416007605	motif 3; other site
86416007606	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
86416007607	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
86416007608	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
86416007609	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
86416007610	23S rRNA binding site [nucleotide binding]; other site
86416007611	L21 binding site [polypeptide binding]; other site
86416007612	L13 binding site [polypeptide binding]; other site
86416007613	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
86416007614	translation initiation factor IF-3; Region: infC; TIGR00168
86416007615	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
86416007616	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
86416007617	Ribosomal protein L20 leader; Clopa_3094; IMG reference gene:2509570011
86416007618	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
86416007619	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
86416007620	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
86416007621	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
86416007622	active site
86416007623	dimer interface [polypeptide binding]; other site
86416007624	motif 1; other site
86416007625	motif 2; other site
86416007626	motif 3; other site
86416007627	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
86416007628	anticodon binding site; other site
86416007629	YtxC-like family; Region: YtxC; pfam08812
86416007630	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
86416007631	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
86416007632	dimerization interface [polypeptide binding]; other site
86416007633	domain crossover interface; other site
86416007634	redox-dependent activation switch; other site
86416007635	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416007636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416007637	S-adenosylmethionine binding site [chemical binding]; other site
86416007638	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416007639	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
86416007640	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
86416007641	dimer interface [polypeptide binding]; other site
86416007642	active site
86416007643	catalytic residue [active]
86416007644	dihydrodipicolinate reductase; Provisional; Region: PRK00048
86416007645	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
86416007646	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
86416007647	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
86416007648	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
86416007649	peptide binding site [polypeptide binding]; other site
86416007650	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
86416007651	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416007652	Walker A/P-loop; other site
86416007653	ATP binding site [chemical binding]; other site
86416007654	Q-loop/lid; other site
86416007655	ABC transporter signature motif; other site
86416007656	Walker B; other site
86416007657	D-loop; other site
86416007658	H-loop/switch region; other site
86416007659	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
86416007660	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
86416007661	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416007662	Walker A/P-loop; other site
86416007663	ATP binding site [chemical binding]; other site
86416007664	Q-loop/lid; other site
86416007665	ABC transporter signature motif; other site
86416007666	Walker B; other site
86416007667	D-loop; other site
86416007668	H-loop/switch region; other site
86416007669	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
86416007670	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
86416007671	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
86416007672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416007673	dimer interface [polypeptide binding]; other site
86416007674	conserved gate region; other site
86416007675	putative PBP binding loops; other site
86416007676	ABC-ATPase subunit interface; other site
86416007677	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
86416007678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416007679	dimer interface [polypeptide binding]; other site
86416007680	conserved gate region; other site
86416007681	putative PBP binding loops; other site
86416007682	ABC-ATPase subunit interface; other site
86416007683	aminotransferase A; Validated; Region: PRK07683
86416007684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416007685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007686	homodimer interface [polypeptide binding]; other site
86416007687	catalytic residue [active]
86416007688	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
86416007689	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
86416007690	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
86416007691	active site
86416007692	trimer interface [polypeptide binding]; other site
86416007693	substrate binding site [chemical binding]; other site
86416007694	CoA binding site [chemical binding]; other site
86416007695	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416007696	putative CoA binding site [chemical binding]; other site
86416007697	putative trimer interface [polypeptide binding]; other site
86416007698	single-stranded DNA-binding protein; Provisional; Region: PRK05813
86416007699	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416007700	dimer interface [polypeptide binding]; other site
86416007701	ssDNA binding site [nucleotide binding]; other site
86416007702	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416007703	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416007704	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
86416007705	NodB motif; other site
86416007706	active site
86416007707	catalytic site [active]
86416007708	metal binding site [ion binding]; metal-binding site
86416007709	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
86416007710	Uncharacterized conserved protein [Function unknown]; Region: COG3391
86416007711	TSCPD domain; Region: TSCPD; cl14834
86416007712	acetylornithine aminotransferase; Provisional; Region: PRK02627
86416007713	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
86416007714	inhibitor-cofactor binding pocket; inhibition site
86416007715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007716	catalytic residue [active]
86416007717	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
86416007718	homohexameric interface [polypeptide binding]; other site
86416007719	feedback inhibition sensing region; other site
86416007720	nucleotide binding site [chemical binding]; other site
86416007721	N-acetyl-L-glutamate binding site [chemical binding]; other site
86416007722	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
86416007723	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
86416007724	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
86416007725	heterotetramer interface [polypeptide binding]; other site
86416007726	active site pocket [active]
86416007727	cleavage site
86416007728	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
86416007729	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
86416007730	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
86416007731	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
86416007732	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
86416007733	active site
86416007734	HIGH motif; other site
86416007735	nucleotide binding site [chemical binding]; other site
86416007736	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
86416007737	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
86416007738	active site
86416007739	KMSKS motif; other site
86416007740	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
86416007741	tRNA binding surface [nucleotide binding]; other site
86416007742	anticodon binding site; other site
86416007743	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
86416007744	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
86416007745	active site
86416007746	substrate binding site [chemical binding]; other site
86416007747	ATP binding site [chemical binding]; other site
86416007748	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
86416007749	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
86416007750	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
86416007751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
86416007752	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
86416007753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
86416007754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416007755	binding surface
86416007756	TPR repeat; Region: TPR_11; pfam13414
86416007757	TPR motif; other site
86416007758	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
86416007759	Coat F domain; Region: Coat_F; pfam07875
86416007760	aspartate racemase; Region: asp_race; TIGR00035
86416007761	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416007762	putative transposase OrfB; Reviewed; Region: PHA02517
86416007763	HTH-like domain; Region: HTH_21; pfam13276
86416007764	Integrase core domain; Region: rve; pfam00665
86416007765	Integrase core domain; Region: rve_3; pfam13683
86416007766	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
86416007767	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
86416007768	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
86416007769	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
86416007770	CHC2 zinc finger; Region: zf-CHC2; cl17510
86416007771	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
86416007772	active site
86416007773	metal binding site [ion binding]; metal-binding site
86416007774	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
86416007775	ERCC4 domain; Region: ERCC4; cl10594
86416007776	N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338
86416007777	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
86416007778	YmaF family; Region: YmaF; pfam12788
86416007779	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416007780	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416007781	dimer interface [polypeptide binding]; other site
86416007782	ssDNA binding site [nucleotide binding]; other site
86416007783	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416007784	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416007785	RecT family; Region: RecT; cl04285
86416007786	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
86416007787	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416007788	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416007789	DNA binding residues [nucleotide binding]
86416007790	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
86416007791	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416007792	non-specific DNA binding site [nucleotide binding]; other site
86416007793	salt bridge; other site
86416007794	sequence-specific DNA binding site [nucleotide binding]; other site
86416007795	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416007796	non-specific DNA binding site [nucleotide binding]; other site
86416007797	salt bridge; other site
86416007798	sequence-specific DNA binding site [nucleotide binding]; other site
86416007799	Domain of unknown function (DUF955); Region: DUF955; pfam06114
86416007800	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
86416007801	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416007802	Int/Topo IB signature motif; other site
86416007803	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
86416007804	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
86416007805	RecX family; Region: RecX; cl00936
86416007806	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
86416007807	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
86416007808	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
86416007809	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
86416007810	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
86416007811	ATP binding site [chemical binding]; other site
86416007812	Mg++ binding site [ion binding]; other site
86416007813	motif III; other site
86416007814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416007815	nucleotide binding region [chemical binding]; other site
86416007816	ATP-binding site [chemical binding]; other site
86416007817	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
86416007818	RNA binding site [nucleotide binding]; other site
86416007819	Uncharacterized conserved protein [Function unknown]; Region: COG1543
86416007820	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
86416007821	active site
86416007822	substrate binding site [chemical binding]; other site
86416007823	catalytic site [active]
86416007824	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
86416007825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
86416007826	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
86416007827	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
86416007828	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
86416007829	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
86416007830	catalytic residue [active]
86416007831	putative FPP diphosphate  binding site; other site
86416007832	putative FPP binding hydrophobic cleft; other site
86416007833	dimer interface [polypeptide binding]; other site
86416007834	putative IPP diphosphate binding site; other site
86416007835	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
86416007836	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
86416007837	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
86416007838	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
86416007839	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
86416007840	protein binding site [polypeptide binding]; other site
86416007841	HAMP domain; Region: HAMP; pfam00672
86416007842	dimerization interface [polypeptide binding]; other site
86416007843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416007844	dimer interface [polypeptide binding]; other site
86416007845	phosphorylation site [posttranslational modification]
86416007846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416007847	ATP binding site [chemical binding]; other site
86416007848	Mg2+ binding site [ion binding]; other site
86416007849	G-X-G motif; other site
86416007850	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416007851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416007852	active site
86416007853	phosphorylation site [posttranslational modification]
86416007854	intermolecular recognition site; other site
86416007855	dimerization interface [polypeptide binding]; other site
86416007856	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416007857	DNA binding site [nucleotide binding]
86416007858	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416007859	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416007860	NodB motif; other site
86416007861	active site
86416007862	catalytic site [active]
86416007863	Zn binding site [ion binding]; other site
86416007864	Probable zinc-binding domain; Region: zf-trcl; pfam13451
86416007865	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
86416007866	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
86416007867	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
86416007868	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
86416007869	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416007870	catalytic residue [active]
86416007871	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416007872	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416007873	dimer interface [polypeptide binding]; other site
86416007874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416007875	catalytic residue [active]
86416007876	Predicted transcriptional regulator [Transcription]; Region: COG1959
86416007877	Transcriptional regulator; Region: Rrf2; cl17282
86416007878	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
86416007879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
86416007880	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
86416007881	Probable transposase; Region: OrfB_IS605; pfam01385
86416007882	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
86416007883	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
86416007884	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416007885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416007886	non-specific DNA binding site [nucleotide binding]; other site
86416007887	salt bridge; other site
86416007888	sequence-specific DNA binding site [nucleotide binding]; other site
86416007889	Protein of unknown function (DUF3606); Region: DUF3606; pfam12244
86416007890	Superoxide dismutase [Fe]; Provisional; Region: PTZ00078
86416007891	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
86416007892	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416007893	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416007894	active site
86416007895	TDP-binding site; other site
86416007896	acceptor substrate-binding pocket; other site
86416007897	homodimer interface [polypeptide binding]; other site
86416007898	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
86416007899	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416007900	putative trimer interface [polypeptide binding]; other site
86416007901	putative CoA binding site [chemical binding]; other site
86416007902	ykkC-yxkD leader; Clopa_3202; IMG reference gene:2509570119
86416007903	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416007904	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416007905	Coenzyme A binding pocket [chemical binding]; other site
86416007906	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416007907	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416007908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416007909	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416007910	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416007911	active site
86416007912	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416007913	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416007914	Holin family; Region: Phage_holin_4; pfam05105
86416007915	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
86416007916	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416007917	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416007918	dimer interface [polypeptide binding]; other site
86416007919	ssDNA binding site [nucleotide binding]; other site
86416007920	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416007921	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416007922	proteasome-activating nucleotidase; Provisional; Region: PRK03992
86416007923	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
86416007924	Poxvirus protein I1; Region: Pox_I1; cl17575
86416007925	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416007926	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
86416007927	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
86416007928	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
86416007929	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
86416007930	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
86416007931	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
86416007932	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
86416007933	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
86416007934	NAD synthetase; Reviewed; Region: nadE; PRK02628
86416007935	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
86416007936	multimer interface [polypeptide binding]; other site
86416007937	active site
86416007938	catalytic triad [active]
86416007939	protein interface 1 [polypeptide binding]; other site
86416007940	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
86416007941	homodimer interface [polypeptide binding]; other site
86416007942	NAD binding pocket [chemical binding]; other site
86416007943	ATP binding pocket [chemical binding]; other site
86416007944	Mg binding site [ion binding]; other site
86416007945	active-site loop [active]
86416007946	Protein of unknown function (DUF327); Region: DUF327; pfam03885
86416007947	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
86416007948	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
86416007949	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416007950	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
86416007951	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
86416007952	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
86416007953	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
86416007954	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
86416007955	trimer interface [polypeptide binding]; other site
86416007956	putative metal binding site [ion binding]; other site
86416007957	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
86416007958	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
86416007959	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
86416007960	ACS interaction site; other site
86416007961	CODH interaction site; other site
86416007962	cubane metal cluster (B-cluster) [ion binding]; other site
86416007963	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
86416007964	Rrf2 family protein; Region: rrf2_super; TIGR00738
86416007965	Transcriptional regulator; Region: Rrf2; pfam02082
86416007966	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
86416007967	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
86416007968	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
86416007969	active site
86416007970	dimer interface [polypeptide binding]; other site
86416007971	effector binding site; other site
86416007972	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
86416007973	TSCPD domain; Region: TSCPD; pfam12637
86416007974	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416007975	Coenzyme A binding pocket [chemical binding]; other site
86416007976	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
86416007977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416007978	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416007979	putative substrate translocation pore; other site
86416007980	FMN-binding domain; Region: FMN_bind; cl01081
86416007981	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
86416007982	E-class dimer interface [polypeptide binding]; other site
86416007983	P-class dimer interface [polypeptide binding]; other site
86416007984	active site
86416007985	Cu2+ binding site [ion binding]; other site
86416007986	Zn2+ binding site [ion binding]; other site
86416007987	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
86416007988	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
86416007989	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
86416007990	active site
86416007991	HIGH motif; other site
86416007992	KMSK motif region; other site
86416007993	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
86416007994	tRNA binding surface [nucleotide binding]; other site
86416007995	anticodon binding site; other site
86416007996	polyphosphate kinase; Provisional; Region: PRK05443
86416007997	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
86416007998	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
86416007999	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
86416008000	putative domain interface [polypeptide binding]; other site
86416008001	putative active site [active]
86416008002	catalytic site [active]
86416008003	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
86416008004	putative domain interface [polypeptide binding]; other site
86416008005	putative active site [active]
86416008006	catalytic site [active]
86416008007	exopolyphosphatase; Region: exo_poly_only; TIGR03706
86416008008	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
86416008009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416008010	Zn2+ binding site [ion binding]; other site
86416008011	Mg2+ binding site [ion binding]; other site
86416008012	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
86416008013	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
86416008014	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
86416008015	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
86416008016	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416008017	active site
86416008018	motif I; other site
86416008019	motif II; other site
86416008020	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
86416008021	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416008022	putative metal binding site [ion binding]; other site
86416008023	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
86416008024	Fic/DOC family; Region: Fic; cl00960
86416008025	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
86416008026	Ligand Binding Site [chemical binding]; other site
86416008027	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
86416008028	active site
86416008029	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
86416008030	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
86416008031	domain interfaces; other site
86416008032	active site
86416008033	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
86416008034	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
86416008035	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
86416008036	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416008037	Walker A/P-loop; other site
86416008038	ATP binding site [chemical binding]; other site
86416008039	Q-loop/lid; other site
86416008040	ABC transporter signature motif; other site
86416008041	Walker B; other site
86416008042	D-loop; other site
86416008043	H-loop/switch region; other site
86416008044	Ferritin-like domain; Region: Ferritin; pfam00210
86416008045	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
86416008046	dinuclear metal binding motif [ion binding]; other site
86416008047	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
86416008048	putative deacylase active site [active]
86416008049	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
86416008050	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
86416008051	Uncharacterized conserved protein [Function unknown]; Region: COG1751
86416008052	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
86416008053	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
86416008054	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416008055	motif II; other site
86416008056	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416008057	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
86416008058	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
86416008059	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
86416008060	active site
86416008061	DNA binding site [nucleotide binding]
86416008062	putative acyltransferase; Provisional; Region: PRK05790
86416008063	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
86416008064	dimer interface [polypeptide binding]; other site
86416008065	active site
86416008066	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416008067	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416008068	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
86416008069	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
86416008070	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416008071	putative active site [active]
86416008072	putative metal binding site [ion binding]; other site
86416008073	FtsX-like permease family; Region: FtsX; pfam02687
86416008074	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416008075	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416008076	Walker A/P-loop; other site
86416008077	ATP binding site [chemical binding]; other site
86416008078	Q-loop/lid; other site
86416008079	ABC transporter signature motif; other site
86416008080	Walker B; other site
86416008081	D-loop; other site
86416008082	H-loop/switch region; other site
86416008083	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416008084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
86416008085	Histidine kinase; Region: HisKA_3; pfam07730
86416008086	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
86416008087	ATP binding site [chemical binding]; other site
86416008088	Mg2+ binding site [ion binding]; other site
86416008089	G-X-G motif; other site
86416008090	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
86416008091	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
86416008092	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
86416008093	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
86416008094	putative active site [active]
86416008095	fructuronate transporter; Provisional; Region: PRK10034; cl15264
86416008096	gluconate transporter; Region: gntP; TIGR00791
86416008097	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416008098	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
86416008099	putative NAD(P) binding site [chemical binding]; other site
86416008100	catalytic Zn binding site [ion binding]; other site
86416008101	structural Zn binding site [ion binding]; other site
86416008102	Transcriptional regulators [Transcription]; Region: GntR; COG1802
86416008103	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416008104	DNA-binding site [nucleotide binding]; DNA binding site
86416008105	FCD domain; Region: FCD; pfam07729
86416008106	Putative amidase domain; Region: Amidase_6; pfam12671
86416008107	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
86416008108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416008109	active site
86416008110	phosphorylation site [posttranslational modification]
86416008111	intermolecular recognition site; other site
86416008112	dimerization interface [polypeptide binding]; other site
86416008113	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
86416008114	DNA binding residues [nucleotide binding]
86416008115	dimerization interface [polypeptide binding]; other site
86416008116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
86416008117	Histidine kinase; Region: HisKA_3; pfam07730
86416008118	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
86416008119	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
86416008120	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
86416008121	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
86416008122	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
86416008123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416008124	Walker A/P-loop; other site
86416008125	ATP binding site [chemical binding]; other site
86416008126	Q-loop/lid; other site
86416008127	ABC transporter signature motif; other site
86416008128	Walker B; other site
86416008129	D-loop; other site
86416008130	H-loop/switch region; other site
86416008131	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
86416008132	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
86416008133	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
86416008134	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
86416008135	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416008136	FeS/SAM binding site; other site
86416008137	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
86416008138	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
86416008139	Zn binding site [ion binding]; other site
86416008140	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
86416008141	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
86416008142	diiron binding motif [ion binding]; other site
86416008143	stage V sporulation protein B; Region: spore_V_B; TIGR02900
86416008144	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
86416008145	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
86416008146	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
86416008147	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416008148	RNA binding surface [nucleotide binding]; other site
86416008149	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
86416008150	active site
86416008151	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
86416008152	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
86416008153	metal binding site [ion binding]; metal-binding site
86416008154	dimer interface [polypeptide binding]; other site
86416008155	Cell division protein FtsA; Region: FtsA; smart00842
86416008156	cell division protein FtsA; Region: ftsA; TIGR01174
86416008157	Cell division protein FtsA; Region: FtsA; pfam14450
86416008158	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
86416008159	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
86416008160	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
86416008161	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
86416008162	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
86416008163	NodB motif; other site
86416008164	active site
86416008165	catalytic site [active]
86416008166	Zn binding site [ion binding]; other site
86416008167	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
86416008168	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416008169	ATP binding site [chemical binding]; other site
86416008170	Family description; Region: UvrD_C_2; pfam13538
86416008171	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
86416008172	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
86416008173	active site
86416008174	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
86416008175	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
86416008176	active site
86416008177	nucleophile elbow; other site
86416008178	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416008179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008180	dimer interface [polypeptide binding]; other site
86416008181	conserved gate region; other site
86416008182	putative PBP binding loops; other site
86416008183	ABC-ATPase subunit interface; other site
86416008184	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416008185	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416008186	Walker A/P-loop; other site
86416008187	ATP binding site [chemical binding]; other site
86416008188	Q-loop/lid; other site
86416008189	ABC transporter signature motif; other site
86416008190	Walker B; other site
86416008191	D-loop; other site
86416008192	H-loop/switch region; other site
86416008193	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416008194	NMT1-like family; Region: NMT1_2; pfam13379
86416008195	NMT1/THI5 like; Region: NMT1; pfam09084
86416008196	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
86416008197	trimer interface [polypeptide binding]; other site
86416008198	putative Zn binding site [ion binding]; other site
86416008199	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
86416008200	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
86416008201	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
86416008202	active site
86416008203	multimer interface [polypeptide binding]; other site
86416008204	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
86416008205	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
86416008206	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
86416008207	Nitrogen regulatory protein P-II; Region: P-II; smart00938
86416008208	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
86416008209	Nitrogen regulatory protein P-II; Region: P-II; smart00938
86416008210	CAAX protease self-immunity; Region: Abi; pfam02517
86416008211	Uncharacterized conserved protein [Function unknown]; Region: COG4717
86416008212	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
86416008213	AAA domain; Region: AAA_27; pfam13514
86416008214	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
86416008215	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
86416008216	active site
86416008217	metal binding site [ion binding]; metal-binding site
86416008218	DNA binding site [nucleotide binding]
86416008219	Protein of unknown function, DUF488; Region: DUF488; pfam04343
86416008220	intracellular protease, PfpI family; Region: PfpI; TIGR01382
86416008221	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
86416008222	proposed catalytic triad [active]
86416008223	conserved cys residue [active]
86416008224	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
86416008225	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
86416008226	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
86416008227	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
86416008228	active site
86416008229	HIGH motif; other site
86416008230	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
86416008231	active site
86416008232	KMSKS motif; other site
86416008233	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
86416008234	FAD binding domain; Region: FAD_binding_4; pfam01565
86416008235	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
86416008236	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
86416008237	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
86416008238	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
86416008239	Ligand binding site [chemical binding]; other site
86416008240	Electron transfer flavoprotein domain; Region: ETF; pfam01012
86416008241	Transcriptional regulators [Transcription]; Region: FadR; COG2186
86416008242	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416008243	DNA-binding site [nucleotide binding]; DNA binding site
86416008244	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
86416008245	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
86416008246	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
86416008247	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416008248	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008249	non-specific DNA binding site [nucleotide binding]; other site
86416008250	salt bridge; other site
86416008251	sequence-specific DNA binding site [nucleotide binding]; other site
86416008252	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
86416008253	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
86416008254	active site
86416008255	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
86416008256	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416008257	Holin family; Region: Phage_holin_4; pfam05105
86416008258	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
86416008259	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
86416008260	active site
86416008261	catalytic triad [active]
86416008262	oxyanion hole [active]
86416008263	Phage tail protein; Region: Sipho_tail; cl17486
86416008264	tape measure domain; Region: tape_meas_nterm; TIGR02675
86416008265	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
86416008266	Short C-terminal domain; Region: SHOCT; pfam09851
86416008267	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
86416008268	aromatic chitin/cellulose binding site residues [chemical binding]; other site
86416008269	Phage major tail protein 2; Region: Phage_tail_2; cl11463
86416008270	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
86416008271	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
86416008272	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
86416008273	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
86416008274	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
86416008275	DNA-binding interface [nucleotide binding]; DNA binding site
86416008276	CHC2 zinc finger; Region: zf-CHC2; cl17510
86416008277	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
86416008278	active site
86416008279	metal binding site [ion binding]; metal-binding site
86416008280	ERCC4 domain; Region: ERCC4; cl10594
86416008281	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416008282	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416008283	dimer interface [polypeptide binding]; other site
86416008284	ssDNA binding site [nucleotide binding]; other site
86416008285	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416008286	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416008287	RecT family; Region: RecT; cl04285
86416008288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416008289	AAA domain; Region: AAA_23; pfam13476
86416008290	Walker A/P-loop; other site
86416008291	ATP binding site [chemical binding]; other site
86416008292	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416008293	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008294	non-specific DNA binding site [nucleotide binding]; other site
86416008295	salt bridge; other site
86416008296	sequence-specific DNA binding site [nucleotide binding]; other site
86416008297	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008298	non-specific DNA binding site [nucleotide binding]; other site
86416008299	salt bridge; other site
86416008300	sequence-specific DNA binding site [nucleotide binding]; other site
86416008301	Ribosomal protein P1, P2, and L12p. Ribosomal proteins P1 and P2 are the eukaryotic proteins that are functionally equivalent to bacterial L7/L12. L12p is the archaeal homolog. Unlike other ribosomal proteins, the archaeal L12p and eukaryotic P1 and P2...; Region: Ribosomal_P1_P2_L12p; cl17918
86416008302	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416008303	Int/Topo IB signature motif; other site
86416008304	RNase_H superfamily; Region: RNase_H_2; pfam13482
86416008305	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
86416008306	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
86416008307	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
86416008308	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
86416008309	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
86416008310	Cell division protein FtsA; Region: FtsA; pfam14450
86416008311	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
86416008312	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
86416008313	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
86416008314	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
86416008315	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
86416008316	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
86416008317	Walker A motif; other site
86416008318	ATP binding site [chemical binding]; other site
86416008319	Walker B motif; other site
86416008320	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
86416008321	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
86416008322	RNase_H superfamily; Region: RNase_H_2; pfam13482
86416008323	active site
86416008324	catalytic site [active]
86416008325	substrate binding site [chemical binding]; other site
86416008326	active site
86416008327	substrate binding site [chemical binding]; other site
86416008328	catalytic site [active]
86416008329	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
86416008330	AsnC family; Region: AsnC_trans_reg; pfam01037
86416008331	Uncharacterized conserved protein [Function unknown]; Region: COG2155
86416008332	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
86416008333	nucleotide-binding site [chemical binding]; other site
86416008334	argininosuccinate lyase; Provisional; Region: PRK00855
86416008335	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
86416008336	active sites [active]
86416008337	tetramer interface [polypeptide binding]; other site
86416008338	argininosuccinate synthase; Provisional; Region: PRK13820
86416008339	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
86416008340	ANP binding site [chemical binding]; other site
86416008341	Substrate Binding Site II [chemical binding]; other site
86416008342	Substrate Binding Site I [chemical binding]; other site
86416008343	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
86416008344	isocitrate dehydrogenase; Validated; Region: PRK06451
86416008345	aconitate hydratase; Validated; Region: PRK07229
86416008346	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
86416008347	substrate binding site [chemical binding]; other site
86416008348	ligand binding site [chemical binding]; other site
86416008349	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
86416008350	substrate binding site [chemical binding]; other site
86416008351	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
86416008352	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
86416008353	active site
86416008354	catalytic residues [active]
86416008355	metal binding site [ion binding]; metal-binding site
86416008356	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
86416008357	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
86416008358	putative acyl-acceptor binding pocket; other site
86416008359	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
86416008360	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
86416008361	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416008362	MULE transposase domain; Region: MULE; pfam10551
86416008363	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416008364	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416008365	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416008366	DNA binding residues [nucleotide binding]
86416008367	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
86416008368	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
86416008369	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
86416008370	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
86416008371	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
86416008372	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
86416008373	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
86416008374	catalytic triad [active]
86416008375	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
86416008376	Clp amino terminal domain; Region: Clp_N; pfam02861
86416008377	Clp amino terminal domain; Region: Clp_N; pfam02861
86416008378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416008379	Walker A motif; other site
86416008380	ATP binding site [chemical binding]; other site
86416008381	Walker B motif; other site
86416008382	arginine finger; other site
86416008383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416008384	Walker A motif; other site
86416008385	ATP binding site [chemical binding]; other site
86416008386	Walker B motif; other site
86416008387	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
86416008388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008389	non-specific DNA binding site [nucleotide binding]; other site
86416008390	salt bridge; other site
86416008391	sequence-specific DNA binding site [nucleotide binding]; other site
86416008392	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008393	non-specific DNA binding site [nucleotide binding]; other site
86416008394	salt bridge; other site
86416008395	sequence-specific DNA binding site [nucleotide binding]; other site
86416008396	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
86416008397	RNA/DNA hybrid binding site [nucleotide binding]; other site
86416008398	active site
86416008399	methionine sulfoxide reductase A; Provisional; Region: PRK14054
86416008400	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
86416008401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416008402	putative substrate translocation pore; other site
86416008403	Uncharacterized conserved protein [Function unknown]; Region: COG3379
86416008404	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
86416008405	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
86416008406	active site
86416008407	dimer interfaces [polypeptide binding]; other site
86416008408	catalytic residues [active]
86416008409	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
86416008410	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
86416008411	active site
86416008412	catalytic residues [active]
86416008413	metal binding site [ion binding]; metal-binding site
86416008414	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
86416008415	metal binding site [ion binding]; metal-binding site
86416008416	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
86416008417	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
86416008418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008419	dimer interface [polypeptide binding]; other site
86416008420	conserved gate region; other site
86416008421	putative PBP binding loops; other site
86416008422	ABC-ATPase subunit interface; other site
86416008423	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
86416008424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
86416008425	Nitrogenase_nifN_2: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_2; cd03466
86416008426	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008427	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
86416008428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416008429	FeS/SAM binding site; other site
86416008430	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
86416008431	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
86416008432	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
86416008433	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
86416008434	MoFe protein beta/alpha subunit interactions; other site
86416008435	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008436	Beta subunit P cluster binding residues; other site
86416008437	MoFe protein beta subunit/Fe protein contacts; other site
86416008438	MoFe protein dimer/ dimer interactions; other site
86416008439	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416008440	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
86416008441	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
86416008442	nitrogenase iron protein; Region: nifH; TIGR01287
86416008443	Nucleotide-binding sites [chemical binding]; other site
86416008444	Walker A motif; other site
86416008445	Switch I region of nucleotide binding site; other site
86416008446	Fe4S4 binding sites [ion binding]; other site
86416008447	Switch II region of nucleotide binding site; other site
86416008448	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
86416008449	nitrogenase iron protein; Region: nifH; TIGR01287
86416008450	Nucleotide-binding sites [chemical binding]; other site
86416008451	Walker A motif; other site
86416008452	Switch I region of nucleotide binding site; other site
86416008453	Fe4S4 binding sites [ion binding]; other site
86416008454	Switch II region of nucleotide binding site; other site
86416008455	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416008456	PBP superfamily domain; Region: PBP_like; pfam12727
86416008457	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
86416008458	dimer interface [polypeptide binding]; other site
86416008459	[2Fe-2S] cluster binding site [ion binding]; other site
86416008460	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
86416008461	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
86416008462	ABC-ATPase subunit  interface; other site
86416008463	dimer interface [polypeptide binding]; other site
86416008464	putative PBP binding regions; other site
86416008465	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416008466	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008467	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
86416008468	Nitrogenase_VnfE_like: VnfE subunit of the VnfEN complex_like. This group in addition to VnfE contains a subset of the alpha subunit of the nitrogenase MoFe protein and NifE-like proteins.  The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfE_like; cd01972
86416008469	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416008470	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008471	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910
86416008472	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
86416008473	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
86416008474	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
86416008475	nitrogenase iron protein; Region: nifH; TIGR01287
86416008476	Nucleotide-binding sites [chemical binding]; other site
86416008477	Walker A motif; other site
86416008478	Switch I region of nucleotide binding site; other site
86416008479	Fe4S4 binding sites [ion binding]; other site
86416008480	Switch II region of nucleotide binding site; other site
86416008481	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416008482	PBP superfamily domain; Region: PBP_like; pfam12727
86416008483	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
86416008484	dimer interface [polypeptide binding]; other site
86416008485	[2Fe-2S] cluster binding site [ion binding]; other site
86416008486	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
86416008487	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
86416008488	putative ligand binding residues [chemical binding]; other site
86416008489	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
86416008490	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
86416008491	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
86416008492	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416008493	Walker A/P-loop; other site
86416008494	ATP binding site [chemical binding]; other site
86416008495	Q-loop/lid; other site
86416008496	ABC transporter signature motif; other site
86416008497	Walker B; other site
86416008498	D-loop; other site
86416008499	H-loop/switch region; other site
86416008500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008501	dimer interface [polypeptide binding]; other site
86416008502	conserved gate region; other site
86416008503	putative PBP binding loops; other site
86416008504	ABC-ATPase subunit interface; other site
86416008505	PBP superfamily domain; Region: PBP_like_2; pfam12849
86416008506	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
86416008507	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
86416008508	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008509	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416008510	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416008511	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
86416008512	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
86416008513	Walker A/P-loop; other site
86416008514	ATP binding site [chemical binding]; other site
86416008515	Q-loop/lid; other site
86416008516	ABC transporter signature motif; other site
86416008517	Walker B; other site
86416008518	D-loop; other site
86416008519	H-loop/switch region; other site
86416008520	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
86416008521	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
86416008522	ABC-ATPase subunit  interface; other site
86416008523	dimer interface [polypeptide binding]; other site
86416008524	putative PBP binding regions; other site
86416008525	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
86416008526	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
86416008527	intersubunit interface [polypeptide binding]; other site
86416008528	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
86416008529	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
86416008530	substrate binding site [chemical binding]; other site
86416008531	active site
86416008532	catalytic residues [active]
86416008533	heterodimer interface [polypeptide binding]; other site
86416008534	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
86416008535	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
86416008536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416008537	catalytic residue [active]
86416008538	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
86416008539	active site
86416008540	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
86416008541	active site
86416008542	ribulose/triose binding site [chemical binding]; other site
86416008543	phosphate binding site [ion binding]; other site
86416008544	substrate (anthranilate) binding pocket [chemical binding]; other site
86416008545	product (indole) binding pocket [chemical binding]; other site
86416008546	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
86416008547	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
86416008548	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
86416008549	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
86416008550	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
86416008551	glutamine binding [chemical binding]; other site
86416008552	catalytic triad [active]
86416008553	anthranilate synthase component I; Provisional; Region: PRK13570
86416008554	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
86416008555	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
86416008556	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
86416008557	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
86416008558	tetrameric interface [polypeptide binding]; other site
86416008559	activator binding site; other site
86416008560	NADP binding site [chemical binding]; other site
86416008561	substrate binding site [chemical binding]; other site
86416008562	catalytic residues [active]
86416008563	KWG Leptospira; Region: KWG; pfam07656
86416008564	hypothetical protein; Provisional; Region: PRK04435
86416008565	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
86416008566	homoserine kinase; Provisional; Region: PRK01212
86416008567	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
86416008568	homoserine dehydrogenase; Provisional; Region: PRK06349
86416008569	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
86416008570	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
86416008571	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
86416008572	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
86416008573	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
86416008574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416008575	catalytic residue [active]
86416008576	Sporulation and spore germination; Region: Germane; smart00909
86416008577	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
86416008578	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
86416008579	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
86416008580	Spore germination protein; Region: Spore_permease; cl17796
86416008581	Protein of unknown function DUF116; Region: DUF116; pfam01976
86416008582	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
86416008583	prolyl-tRNA synthetase; Provisional; Region: PRK08661
86416008584	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
86416008585	dimer interface [polypeptide binding]; other site
86416008586	motif 1; other site
86416008587	active site
86416008588	motif 2; other site
86416008589	motif 3; other site
86416008590	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
86416008591	anticodon binding site; other site
86416008592	zinc-binding site [ion binding]; other site
86416008593	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
86416008594	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
86416008595	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
86416008596	G1 box; other site
86416008597	GTP/Mg2+ binding site [chemical binding]; other site
86416008598	Switch I region; other site
86416008599	G2 box; other site
86416008600	G3 box; other site
86416008601	Switch II region; other site
86416008602	G4 box; other site
86416008603	G5 box; other site
86416008604	Nucleoside recognition; Region: Gate; pfam07670
86416008605	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
86416008606	Nucleoside recognition; Region: Gate; pfam07670
86416008607	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
86416008608	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
86416008609	feedback inhibition sensing region; other site
86416008610	homohexameric interface [polypeptide binding]; other site
86416008611	nucleotide binding site [chemical binding]; other site
86416008612	N-acetyl-L-glutamate binding site [chemical binding]; other site
86416008613	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
86416008614	Integral membrane protein TerC family; Region: TerC; cl10468
86416008615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
86416008616	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
86416008617	ArsC family; Region: ArsC; pfam03960
86416008618	catalytic residue [active]
86416008619	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416008620	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416008621	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416008622	dimerization interface [polypeptide binding]; other site
86416008623	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
86416008624	transglutaminase; Provisional; Region: tgl; PRK03187
86416008625	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
86416008626	Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185
86416008627	putative ligand binding site [chemical binding]; other site
86416008628	putative NAD binding site [chemical binding]; other site
86416008629	catalytic site [active]
86416008630	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
86416008631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416008632	FeS/SAM binding site; other site
86416008633	EcsC protein family; Region: EcsC; pfam12787
86416008634	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
86416008635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416008636	Coenzyme A binding pocket [chemical binding]; other site
86416008637	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
86416008638	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
86416008639	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008640	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
86416008641	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008642	Leucine-rich repeats; other site
86416008643	Substrate binding site [chemical binding]; other site
86416008644	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008645	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008646	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008647	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
86416008648	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
86416008649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008650	dimer interface [polypeptide binding]; other site
86416008651	conserved gate region; other site
86416008652	ABC-ATPase subunit interface; other site
86416008653	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
86416008654	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
86416008655	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
86416008656	Walker A/P-loop; other site
86416008657	ATP binding site [chemical binding]; other site
86416008658	Q-loop/lid; other site
86416008659	ABC transporter signature motif; other site
86416008660	Walker B; other site
86416008661	D-loop; other site
86416008662	H-loop/switch region; other site
86416008663	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
86416008664	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
86416008665	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416008666	active site
86416008667	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416008668	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416008669	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
86416008670	Walker A/P-loop; other site
86416008671	ATP binding site [chemical binding]; other site
86416008672	Q-loop/lid; other site
86416008673	ABC transporter signature motif; other site
86416008674	Walker B; other site
86416008675	D-loop; other site
86416008676	H-loop/switch region; other site
86416008677	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
86416008678	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
86416008679	trimer interface [polypeptide binding]; other site
86416008680	active site
86416008681	substrate binding site [chemical binding]; other site
86416008682	CoA binding site [chemical binding]; other site
86416008683	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
86416008684	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416008685	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416008686	active site
86416008687	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
86416008688	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416008689	Walker A/P-loop; other site
86416008690	ATP binding site [chemical binding]; other site
86416008691	Q-loop/lid; other site
86416008692	ABC transporter signature motif; other site
86416008693	Walker B; other site
86416008694	D-loop; other site
86416008695	H-loop/switch region; other site
86416008696	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
86416008697	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
86416008698	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455
86416008699	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
86416008700	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
86416008701	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416008702	DNA-binding site [nucleotide binding]; DNA binding site
86416008703	UTRA domain; Region: UTRA; pfam07702
86416008704	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
86416008705	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416008706	MULE transposase domain; Region: MULE; pfam10551
86416008707	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416008708	non-specific DNA binding site [nucleotide binding]; other site
86416008709	salt bridge; other site
86416008710	sequence-specific DNA binding site [nucleotide binding]; other site
86416008711	Domain of unknown function (DUF955); Region: DUF955; cl01076
86416008712	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416008713	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
86416008714	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
86416008715	putative active site [active]
86416008716	metal binding site [ion binding]; metal-binding site
86416008717	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416008718	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416008719	DNA binding residues [nucleotide binding]
86416008720	putative dimer interface [polypeptide binding]; other site
86416008721	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416008722	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416008723	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
86416008724	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416008725	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416008726	DNA binding residues [nucleotide binding]
86416008727	putative dimer interface [polypeptide binding]; other site
86416008728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416008729	putative substrate translocation pore; other site
86416008730	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416008731	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416008732	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416008733	active site
86416008734	catalytic tetrad [active]
86416008735	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416008736	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416008737	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
86416008738	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
86416008739	dimer interface [polypeptide binding]; other site
86416008740	active site
86416008741	metal binding site [ion binding]; metal-binding site
86416008742	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416008743	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416008744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416008745	dimerization interface [polypeptide binding]; other site
86416008746	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
86416008747	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
86416008748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416008749	S-adenosylmethionine binding site [chemical binding]; other site
86416008750	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
86416008751	dimer interface [polypeptide binding]; other site
86416008752	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416008753	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
86416008754	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
86416008755	domain interfaces; other site
86416008756	active site
86416008757	6-phosphofructokinase; Provisional; Region: PRK03202
86416008758	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
86416008759	active site
86416008760	ADP/pyrophosphate binding site [chemical binding]; other site
86416008761	dimerization interface [polypeptide binding]; other site
86416008762	allosteric effector site; other site
86416008763	fructose-1,6-bisphosphate binding site; other site
86416008764	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
86416008765	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
86416008766	active site
86416008767	PHP Thumb interface [polypeptide binding]; other site
86416008768	metal binding site [ion binding]; metal-binding site
86416008769	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
86416008770	generic binding surface II; other site
86416008771	generic binding surface I; other site
86416008772	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
86416008773	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
86416008774	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416008775	DNA-binding site [nucleotide binding]; DNA binding site
86416008776	DRTGG domain; Region: DRTGG; pfam07085
86416008777	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
86416008778	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
86416008779	active site 2 [active]
86416008780	active site 1 [active]
86416008781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
86416008782	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
86416008783	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
86416008784	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
86416008785	phosphate binding site [ion binding]; other site
86416008786	putative substrate binding pocket [chemical binding]; other site
86416008787	dimer interface [polypeptide binding]; other site
86416008788	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
86416008789	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
86416008790	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
86416008791	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
86416008792	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
86416008793	FAD binding domain; Region: FAD_binding_4; pfam01565
86416008794	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
86416008795	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
86416008796	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
86416008797	GIY-YIG motif/motif A; other site
86416008798	active site
86416008799	catalytic site [active]
86416008800	putative DNA binding site [nucleotide binding]; other site
86416008801	metal binding site [ion binding]; metal-binding site
86416008802	UvrB/uvrC motif; Region: UVR; pfam02151
86416008803	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
86416008804	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
86416008805	DNA binding site [nucleotide binding]
86416008806	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
86416008807	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416008808	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
86416008809	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
86416008810	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
86416008811	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
86416008812	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
86416008813	phosphopeptide binding site; other site
86416008814	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
86416008815	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
86416008816	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
86416008817	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
86416008818	excinuclease ABC subunit B; Provisional; Region: PRK05298
86416008819	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416008820	ATP binding site [chemical binding]; other site
86416008821	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416008822	nucleotide binding region [chemical binding]; other site
86416008823	ATP-binding site [chemical binding]; other site
86416008824	Ultra-violet resistance protein B; Region: UvrB; pfam12344
86416008825	UvrB/uvrC motif; Region: UVR; pfam02151
86416008826	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
86416008827	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
86416008828	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
86416008829	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
86416008830	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
86416008831	protein binding site [polypeptide binding]; other site
86416008832	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
86416008833	Catalytic dyad [active]
86416008834	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
86416008835	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
86416008836	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
86416008837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416008838	Walker A/P-loop; other site
86416008839	ATP binding site [chemical binding]; other site
86416008840	Q-loop/lid; other site
86416008841	ABC transporter signature motif; other site
86416008842	Walker B; other site
86416008843	D-loop; other site
86416008844	H-loop/switch region; other site
86416008845	Uncharacterized conserved protein [Function unknown]; Region: COG1284
86416008846	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
86416008847	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
86416008848	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416008849	N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791
86416008850	putative active site [active]
86416008851	catalytic site [active]
86416008852	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
86416008853	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
86416008854	active site
86416008855	PHP-associated; Region: PHP_C; pfam13263
86416008856	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416008857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008858	dimer interface [polypeptide binding]; other site
86416008859	conserved gate region; other site
86416008860	ABC-ATPase subunit interface; other site
86416008861	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416008862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416008863	dimer interface [polypeptide binding]; other site
86416008864	conserved gate region; other site
86416008865	putative PBP binding loops; other site
86416008866	ABC-ATPase subunit interface; other site
86416008867	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416008868	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416008869	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
86416008870	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
86416008871	Walker A/P-loop; other site
86416008872	ATP binding site [chemical binding]; other site
86416008873	Q-loop/lid; other site
86416008874	ABC transporter signature motif; other site
86416008875	Walker B; other site
86416008876	D-loop; other site
86416008877	H-loop/switch region; other site
86416008878	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416008879	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416008880	DNA binding site [nucleotide binding]
86416008881	domain linker motif; other site
86416008882	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416008883	ligand binding site [chemical binding]; other site
86416008884	dimerization interface [polypeptide binding]; other site
86416008885	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
86416008886	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
86416008887	PYR/PP interface [polypeptide binding]; other site
86416008888	dimer interface [polypeptide binding]; other site
86416008889	TPP binding site [chemical binding]; other site
86416008890	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416008891	transketolase; Reviewed; Region: PRK05899
86416008892	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
86416008893	TPP-binding site [chemical binding]; other site
86416008894	dimer interface [polypeptide binding]; other site
86416008895	PemK-like protein; Region: PemK; pfam02452
86416008896	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
86416008897	alanine racemase; Reviewed; Region: alr; PRK00053
86416008898	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
86416008899	active site
86416008900	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
86416008901	dimer interface [polypeptide binding]; other site
86416008902	substrate binding site [chemical binding]; other site
86416008903	catalytic residues [active]
86416008904	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
86416008905	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
86416008906	Uncharacterized conserved protein [Function unknown]; Region: COG0062
86416008907	putative carbohydrate kinase; Provisional; Region: PRK10565
86416008908	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
86416008909	putative substrate binding site [chemical binding]; other site
86416008910	putative ATP binding site [chemical binding]; other site
86416008911	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
86416008912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
86416008913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
86416008914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416008915	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
86416008916	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
86416008917	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416008918	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416008919	FtsX-like permease family; Region: FtsX; pfam02687
86416008920	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416008921	FtsX-like permease family; Region: FtsX; pfam02687
86416008922	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416008923	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416008924	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416008925	Walker A/P-loop; other site
86416008926	ATP binding site [chemical binding]; other site
86416008927	Q-loop/lid; other site
86416008928	ABC transporter signature motif; other site
86416008929	Walker B; other site
86416008930	D-loop; other site
86416008931	H-loop/switch region; other site
86416008932	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
86416008933	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416008934	active site
86416008935	dimer interface [polypeptide binding]; other site
86416008936	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
86416008937	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
86416008938	conserved cys residue [active]
86416008939	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
86416008940	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
86416008941	putative active site [active]
86416008942	metal binding site [ion binding]; metal-binding site
86416008943	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
86416008944	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
86416008945	metal binding site [ion binding]; metal-binding site
86416008946	active site
86416008947	I-site; other site
86416008948	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416008949	Zn2+ binding site [ion binding]; other site
86416008950	Mg2+ binding site [ion binding]; other site
86416008951	Staphylococcal AgrD protein; Region: AgrD; cl05477
86416008952	Accessory gene regulator B; Region: AgrB; pfam04647
86416008953	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
86416008954	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416008955	RNA binding surface [nucleotide binding]; other site
86416008956	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
86416008957	active site
86416008958	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
86416008959	SmpB-tmRNA interface; other site
86416008960	ribonuclease R; Region: RNase_R; TIGR02063
86416008961	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
86416008962	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
86416008963	RNB domain; Region: RNB; pfam00773
86416008964	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
86416008965	RNA binding site [nucleotide binding]; other site
86416008966	Preprotein translocase SecG subunit; Region: SecG; pfam03840
86416008967	enolase; Provisional; Region: eno; PRK00077
86416008968	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
86416008969	dimer interface [polypeptide binding]; other site
86416008970	metal binding site [ion binding]; metal-binding site
86416008971	substrate binding pocket [chemical binding]; other site
86416008972	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
86416008973	phosphoglyceromutase; Provisional; Region: PRK05434
86416008974	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
86416008975	triosephosphate isomerase; Provisional; Region: PRK14565
86416008976	substrate binding site [chemical binding]; other site
86416008977	dimer interface [polypeptide binding]; other site
86416008978	catalytic triad [active]
86416008979	Phosphoglycerate kinase; Region: PGK; pfam00162
86416008980	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
86416008981	substrate binding site [chemical binding]; other site
86416008982	hinge regions; other site
86416008983	ADP binding site [chemical binding]; other site
86416008984	catalytic site [active]
86416008985	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
86416008986	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
86416008987	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
86416008988	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
86416008989	Predicted transcriptional regulator [Transcription]; Region: COG3388
86416008990	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
86416008991	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
86416008992	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
86416008993	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
86416008994	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
86416008995	EDD domain protein, DegV family; Region: DegV; TIGR00762
86416008996	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
86416008997	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
86416008998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416008999	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
86416009000	active site
86416009001	motif I; other site
86416009002	motif II; other site
86416009003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416009004	motif II; other site
86416009005	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416009006	RyR domain; Region: RyR; pfam02026
86416009007	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
86416009008	Domain of unknown function DUF20; Region: UPF0118; pfam01594
86416009009	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416009010	MarR family; Region: MarR; pfam01047
86416009011	arsenical pump membrane protein; Provisional; Region: PRK15445
86416009012	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
86416009013	transmembrane helices; other site
86416009014	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
86416009015	Uncharacterized conserved protein [Function unknown]; Region: COG1633
86416009016	dinuclear metal binding motif [ion binding]; other site
86416009017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416009018	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
86416009019	active site
86416009020	motif I; other site
86416009021	motif II; other site
86416009022	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416009023	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
86416009024	putative FMN binding site [chemical binding]; other site
86416009025	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
86416009026	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
86416009027	active site
86416009028	FMN binding site [chemical binding]; other site
86416009029	substrate binding site [chemical binding]; other site
86416009030	homotetramer interface [polypeptide binding]; other site
86416009031	catalytic residue [active]
86416009032	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416009033	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416009034	aspartate aminotransferase; Provisional; Region: PRK06836
86416009035	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416009036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416009037	homodimer interface [polypeptide binding]; other site
86416009038	catalytic residue [active]
86416009039	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
86416009040	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
86416009041	active site
86416009042	metal binding site [ion binding]; metal-binding site
86416009043	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
86416009044	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
86416009045	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
86416009046	active site
86416009047	metal binding site [ion binding]; metal-binding site
86416009048	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
86416009049	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416009050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416009051	active site
86416009052	phosphorylation site [posttranslational modification]
86416009053	intermolecular recognition site; other site
86416009054	dimerization interface [polypeptide binding]; other site
86416009055	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416009056	DNA binding site [nucleotide binding]
86416009057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
86416009058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416009059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416009060	dimer interface [polypeptide binding]; other site
86416009061	phosphorylation site [posttranslational modification]
86416009062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416009063	ATP binding site [chemical binding]; other site
86416009064	Mg2+ binding site [ion binding]; other site
86416009065	G-X-G motif; other site
86416009066	FAD binding domain; Region: FAD_binding_4; pfam01565
86416009067	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
86416009068	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
86416009069	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
86416009070	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
86416009071	Walker A/P-loop; other site
86416009072	ATP binding site [chemical binding]; other site
86416009073	Q-loop/lid; other site
86416009074	ABC transporter signature motif; other site
86416009075	Walker B; other site
86416009076	D-loop; other site
86416009077	H-loop/switch region; other site
86416009078	NIL domain; Region: NIL; pfam09383
86416009079	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
86416009080	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
86416009081	Transposase domain (DUF772); Region: DUF772; pfam05598
86416009082	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416009083	Propionate catabolism activator; Region: PrpR_N; pfam06506
86416009084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009085	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
86416009086	Walker A motif; other site
86416009087	ATP binding site [chemical binding]; other site
86416009088	Walker B motif; other site
86416009089	arginine finger; other site
86416009090	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
86416009091	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416009092	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
86416009093	NAD(P) binding site [chemical binding]; other site
86416009094	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
86416009095	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
86416009096	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
86416009097	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
86416009098	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
86416009099	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
86416009100	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
86416009101	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
86416009102	Walker A/P-loop; other site
86416009103	ATP binding site [chemical binding]; other site
86416009104	Q-loop/lid; other site
86416009105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416009106	ABC transporter signature motif; other site
86416009107	Walker B; other site
86416009108	D-loop; other site
86416009109	H-loop/switch region; other site
86416009110	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
86416009111	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
86416009112	active site
86416009113	metal binding site [ion binding]; metal-binding site
86416009114	DNA binding site [nucleotide binding]
86416009115	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
86416009116	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
86416009117	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
86416009118	5S rRNA interface [nucleotide binding]; other site
86416009119	CTC domain interface [polypeptide binding]; other site
86416009120	L16 interface [polypeptide binding]; other site
86416009121	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
86416009122	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
86416009123	N- and C-terminal domain interface [polypeptide binding]; other site
86416009124	putative active site [active]
86416009125	MgATP binding site [chemical binding]; other site
86416009126	catalytic site [active]
86416009127	metal binding site [ion binding]; metal-binding site
86416009128	putative xylulose binding site [chemical binding]; other site
86416009129	putative homodimer interface [polypeptide binding]; other site
86416009130	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
86416009131	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
86416009132	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416009133	active site turn [active]
86416009134	phosphorylation site [posttranslational modification]
86416009135	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416009136	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416009137	HPr interaction site; other site
86416009138	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416009139	active site
86416009140	phosphorylation site [posttranslational modification]
86416009141	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
86416009142	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
86416009143	NAD binding site [chemical binding]; other site
86416009144	sugar binding site [chemical binding]; other site
86416009145	divalent metal binding site [ion binding]; other site
86416009146	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416009147	dimer interface [polypeptide binding]; other site
86416009148	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416009149	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416009150	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416009151	putative active site [active]
86416009152	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416009153	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
86416009154	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
86416009155	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
86416009156	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
86416009157	TPP-binding site [chemical binding]; other site
86416009158	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
86416009159	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
86416009160	dimer interface [polypeptide binding]; other site
86416009161	PYR/PP interface [polypeptide binding]; other site
86416009162	TPP binding site [chemical binding]; other site
86416009163	substrate binding site [chemical binding]; other site
86416009164	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416009165	Ferredoxin [Energy production and conversion]; Region: COG1146
86416009166	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416009167	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416009168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009169	dimer interface [polypeptide binding]; other site
86416009170	conserved gate region; other site
86416009171	putative PBP binding loops; other site
86416009172	ABC-ATPase subunit interface; other site
86416009173	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
86416009174	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416009175	substrate binding pocket [chemical binding]; other site
86416009176	membrane-bound complex binding site; other site
86416009177	hinge residues; other site
86416009178	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
86416009179	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
86416009180	acyl-activating enzyme (AAE) consensus motif; other site
86416009181	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
86416009182	putative AMP binding site [chemical binding]; other site
86416009183	putative active site [active]
86416009184	acyl-activating enzyme (AAE) consensus motif; other site
86416009185	putative CoA binding site [chemical binding]; other site
86416009186	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416009187	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416009188	Walker A/P-loop; other site
86416009189	ATP binding site [chemical binding]; other site
86416009190	Q-loop/lid; other site
86416009191	ABC transporter signature motif; other site
86416009192	Walker B; other site
86416009193	D-loop; other site
86416009194	H-loop/switch region; other site
86416009195	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
86416009196	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
86416009197	LytTr DNA-binding domain; Region: LytTR; smart00850
86416009198	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
86416009199	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
86416009200	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
86416009201	ATP binding site [chemical binding]; other site
86416009202	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
86416009203	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
86416009204	NAD(P) binding site [chemical binding]; other site
86416009205	LDH/MDH dimer interface [polypeptide binding]; other site
86416009206	substrate binding site [chemical binding]; other site
86416009207	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416009208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009209	dimer interface [polypeptide binding]; other site
86416009210	conserved gate region; other site
86416009211	putative PBP binding loops; other site
86416009212	ABC-ATPase subunit interface; other site
86416009213	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416009214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009215	putative PBP binding loops; other site
86416009216	dimer interface [polypeptide binding]; other site
86416009217	ABC-ATPase subunit interface; other site
86416009218	Amidohydrolase; Region: Amidohydro_2; pfam04909
86416009219	active site
86416009220	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416009221	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416009222	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416009223	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416009224	DNA binding site [nucleotide binding]
86416009225	domain linker motif; other site
86416009226	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416009227	dimerization interface [polypeptide binding]; other site
86416009228	ligand binding site [chemical binding]; other site
86416009229	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416009230	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
86416009231	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
86416009232	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
86416009233	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
86416009234	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
86416009235	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416009236	Walker A/P-loop; other site
86416009237	ATP binding site [chemical binding]; other site
86416009238	Q-loop/lid; other site
86416009239	ABC transporter signature motif; other site
86416009240	Walker B; other site
86416009241	D-loop; other site
86416009242	H-loop/switch region; other site
86416009243	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416009244	Walker A/P-loop; other site
86416009245	ATP binding site [chemical binding]; other site
86416009246	Q-loop/lid; other site
86416009247	ABC transporter signature motif; other site
86416009248	Walker B; other site
86416009249	D-loop; other site
86416009250	H-loop/switch region; other site
86416009251	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416009252	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416009253	Walker A/P-loop; other site
86416009254	ATP binding site [chemical binding]; other site
86416009255	Q-loop/lid; other site
86416009256	ABC transporter signature motif; other site
86416009257	Walker B; other site
86416009258	D-loop; other site
86416009259	H-loop/switch region; other site
86416009260	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416009261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009262	putative PBP binding loops; other site
86416009263	dimer interface [polypeptide binding]; other site
86416009264	ABC-ATPase subunit interface; other site
86416009265	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416009266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416009267	substrate binding pocket [chemical binding]; other site
86416009268	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
86416009269	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416009270	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416009271	nucleotide binding site [chemical binding]; other site
86416009272	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
86416009273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416009274	FeS/SAM binding site; other site
86416009275	S-adenosylmethionine synthetase; Validated; Region: PRK05250
86416009276	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
86416009277	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
86416009278	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
86416009279	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
86416009280	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
86416009281	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416009282	FeS/SAM binding site; other site
86416009283	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
86416009284	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
86416009285	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
86416009286	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416009287	Walker A/P-loop; other site
86416009288	ATP binding site [chemical binding]; other site
86416009289	Q-loop/lid; other site
86416009290	ABC transporter signature motif; other site
86416009291	Walker B; other site
86416009292	D-loop; other site
86416009293	H-loop/switch region; other site
86416009294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416009295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416009296	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
86416009297	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416009298	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
86416009299	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
86416009300	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416009301	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
86416009302	metal ion-dependent adhesion site (MIDAS); other site
86416009303	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416009304	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416009305	active site
86416009306	metal binding site [ion binding]; metal-binding site
86416009307	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
86416009308	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416009309	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
86416009310	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416009311	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
86416009312	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
86416009313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
86416009314	GntP family permease; Region: GntP_permease; pfam02447
86416009315	fructuronate transporter; Provisional; Region: PRK10034; cl15264
86416009316	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
86416009317	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416009318	ABC transporter; Region: ABC_tran_2; pfam12848
86416009319	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416009320	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
86416009321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009322	putative substrate translocation pore; other site
86416009323	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
86416009324	G1 box; other site
86416009325	GTP/Mg2+ binding site [chemical binding]; other site
86416009326	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
86416009327	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416009328	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416009329	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
86416009330	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
86416009331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416009332	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
86416009333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009334	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416009335	putative substrate translocation pore; other site
86416009336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009337	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
86416009338	classical (c) SDRs; Region: SDR_c; cd05233
86416009339	NAD(P) binding site [chemical binding]; other site
86416009340	active site
86416009341	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416009342	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416009343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416009344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416009345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416009346	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
86416009347	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
86416009348	active site
86416009349	substrate binding site [chemical binding]; other site
86416009350	trimer interface [polypeptide binding]; other site
86416009351	CoA binding site [chemical binding]; other site
86416009352	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009353	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009354	Ca binding site [ion binding]; other site
86416009355	active site
86416009356	catalytic site [active]
86416009357	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
86416009358	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
86416009359	catalytic residues [active]
86416009360	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
86416009361	DAK2 domain; Region: Dak2; pfam02734
86416009362	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
86416009363	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
86416009364	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
86416009365	intersubunit interface [polypeptide binding]; other site
86416009366	active site
86416009367	Zn2+ binding site [ion binding]; other site
86416009368	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
86416009369	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
86416009370	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
86416009371	active site
86416009372	P-loop; other site
86416009373	phosphorylation site [posttranslational modification]
86416009374	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416009375	active site
86416009376	phosphorylation site [posttranslational modification]
86416009377	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
86416009378	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416009379	active site
86416009380	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416009381	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
86416009382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009383	Walker A motif; other site
86416009384	ATP binding site [chemical binding]; other site
86416009385	Walker B motif; other site
86416009386	arginine finger; other site
86416009387	Transcriptional antiterminator [Transcription]; Region: COG3933
86416009388	PRD domain; Region: PRD; pfam00874
86416009389	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416009390	active pocket/dimerization site; other site
86416009391	active site
86416009392	phosphorylation site [posttranslational modification]
86416009393	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133
86416009394	active site
86416009395	P-loop; other site
86416009396	phosphorylation site [posttranslational modification]
86416009397	PRD domain; Region: PRD; pfam00874
86416009398	Amino acid permease; Region: AA_permease_2; pfam13520
86416009399	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416009400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416009401	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416009402	dimerization interface [polypeptide binding]; other site
86416009403	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
86416009404	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
86416009405	substrate binding pocket [chemical binding]; other site
86416009406	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
86416009407	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
86416009408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416009409	Coenzyme A binding pocket [chemical binding]; other site
86416009410	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
86416009411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416009412	FeS/SAM binding site; other site
86416009413	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
86416009414	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
86416009415	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
86416009416	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416009417	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416009418	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416009419	DNA binding residues [nucleotide binding]
86416009420	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
86416009421	catalytic residue [active]
86416009422	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
86416009423	active site
86416009424	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
86416009425	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
86416009426	active site
86416009427	Substrate binding site; other site
86416009428	Mg++ binding site; other site
86416009429	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416009430	putative trimer interface [polypeptide binding]; other site
86416009431	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
86416009432	putative CoA binding site [chemical binding]; other site
86416009433	putative trimer interface [polypeptide binding]; other site
86416009434	putative CoA binding site [chemical binding]; other site
86416009435	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
86416009436	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
86416009437	ABC-2 type transporter; Region: ABC2_membrane; cl17235
86416009438	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416009439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416009440	Walker A/P-loop; other site
86416009441	ATP binding site [chemical binding]; other site
86416009442	Q-loop/lid; other site
86416009443	ABC transporter signature motif; other site
86416009444	Walker B; other site
86416009445	D-loop; other site
86416009446	H-loop/switch region; other site
86416009447	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
86416009448	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416009449	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
86416009450	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
86416009451	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
86416009452	active site
86416009453	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
86416009454	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416009455	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
86416009456	Phosphate transporter family; Region: PHO4; pfam01384
86416009457	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
86416009458	intersubunit interface [polypeptide binding]; other site
86416009459	active site
86416009460	catalytic residue [active]
86416009461	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
86416009462	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
86416009463	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416009464	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416009465	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416009466	MULE transposase domain; Region: MULE; pfam10551
86416009467	Flagellin N-methylase; Region: FliB; pfam03692
86416009468	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
86416009469	Aspartyl protease; Region: Asp_protease_2; pfam13650
86416009470	inhibitor binding site; inhibition site
86416009471	catalytic motif [active]
86416009472	Catalytic residue [active]
86416009473	Active site flap [active]
86416009474	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
86416009475	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
86416009476	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
86416009477	Fic/DOC family; Region: Fic; cl00960
86416009478	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
86416009479	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
86416009480	Membrane protein of unknown function; Region: DUF360; pfam04020
86416009481	Methyltransferase domain; Region: Methyltransf_31; pfam13847
86416009482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416009483	S-adenosylmethionine binding site [chemical binding]; other site
86416009484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416009485	binding surface
86416009486	TPR motif; other site
86416009487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416009488	binding surface
86416009489	TPR repeat; Region: TPR_11; pfam13414
86416009490	TPR motif; other site
86416009491	TPR repeat; Region: TPR_11; pfam13414
86416009492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416009493	binding surface
86416009494	TPR repeat; Region: TPR_11; pfam13414
86416009495	TPR motif; other site
86416009496	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
86416009497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009498	dimer interface [polypeptide binding]; other site
86416009499	conserved gate region; other site
86416009500	putative PBP binding loops; other site
86416009501	ABC-ATPase subunit interface; other site
86416009502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
86416009503	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
86416009504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416009505	Walker A/P-loop; other site
86416009506	ATP binding site [chemical binding]; other site
86416009507	Q-loop/lid; other site
86416009508	ABC transporter signature motif; other site
86416009509	Walker B; other site
86416009510	D-loop; other site
86416009511	H-loop/switch region; other site
86416009512	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416009513	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
86416009514	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
86416009515	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
86416009516	putative active site [active]
86416009517	catalytic site [active]
86416009518	putative metal binding site [ion binding]; other site
86416009519	oligomer interface [polypeptide binding]; other site
86416009520	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416009521	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416009522	DNA binding site [nucleotide binding]
86416009523	domain linker motif; other site
86416009524	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416009525	ligand binding site [chemical binding]; other site
86416009526	dimerization interface [polypeptide binding]; other site
86416009527	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416009528	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416009529	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
86416009530	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
86416009531	active site
86416009532	8-oxo-dGMP binding site [chemical binding]; other site
86416009533	nudix motif; other site
86416009534	metal binding site [ion binding]; metal-binding site
86416009535	chromosome segregation protein; Provisional; Region: PRK03918
86416009536	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416009537	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416009538	MarR family; Region: MarR; pfam01047
86416009539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416009541	putative substrate translocation pore; other site
86416009542	HutD; Region: HutD; pfam05962
86416009543	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
86416009544	Part of AAA domain; Region: AAA_19; pfam13245
86416009545	AAA domain; Region: AAA_12; pfam13087
86416009546	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
86416009547	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416009548	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416009549	putative active site [active]
86416009550	putative NTP binding site [chemical binding]; other site
86416009551	putative nucleic acid binding site [nucleotide binding]; other site
86416009552	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416009553	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416009554	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416009555	aspartate racemase; Region: asp_race; TIGR00035
86416009556	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
86416009557	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
86416009558	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
86416009559	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
86416009560	Integrase core domain; Region: rve; pfam00665
86416009561	transposase/IS protein; Provisional; Region: PRK09183
86416009562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009563	Walker A motif; other site
86416009564	ATP binding site [chemical binding]; other site
86416009565	Walker B motif; other site
86416009566	Nuclease-related domain; Region: NERD; pfam08378
86416009567	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
86416009568	AAA ATPase domain; Region: AAA_16; pfam13191
86416009569	Family description; Region: UvrD_C_2; pfam13538
86416009570	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
86416009571	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
86416009572	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
86416009573	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
86416009574	putative active site [active]
86416009575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416009577	putative substrate translocation pore; other site
86416009578	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416009579	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416009580	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
86416009581	dimerization interface [polypeptide binding]; other site
86416009582	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
86416009583	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
86416009584	DNA binding residues [nucleotide binding]
86416009585	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416009586	putative dimer interface [polypeptide binding]; other site
86416009587	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
86416009588	nucleotide binding site/active site [active]
86416009589	HIT family signature motif; other site
86416009590	catalytic residue [active]
86416009591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
86416009592	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
86416009593	Probable transposase; Region: OrfB_IS605; pfam01385
86416009594	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
86416009595	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
86416009596	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416009597	active site
86416009598	metal binding site [ion binding]; metal-binding site
86416009599	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
86416009600	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
86416009601	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
86416009602	putative ligand binding site [chemical binding]; other site
86416009603	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
86416009604	aspartate racemase; Region: asp_race; TIGR00035
86416009605	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
86416009606	DNA-binding site [nucleotide binding]; DNA binding site
86416009607	RNA-binding motif; other site
86416009608	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
86416009609	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
86416009610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416009611	ATP binding site [chemical binding]; other site
86416009612	putative Mg++ binding site [ion binding]; other site
86416009613	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416009614	nucleotide binding region [chemical binding]; other site
86416009615	ATP-binding site [chemical binding]; other site
86416009616	Protein of unknown function (DUF458); Region: DUF458; pfam04308
86416009617	Cupin domain; Region: Cupin_2; pfam07883
86416009618	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416009619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416009620	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
86416009621	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
86416009622	Metal-binding active site; metal-binding site
86416009623	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
86416009624	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
86416009625	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
86416009626	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
86416009627	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
86416009628	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
86416009629	active site
86416009630	metal binding site [ion binding]; metal-binding site
86416009631	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
86416009632	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
86416009633	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
86416009634	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
86416009635	trimer interface [polypeptide binding]; other site
86416009636	active site
86416009637	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
86416009638	catalytic site [active]
86416009639	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416009640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009641	dimer interface [polypeptide binding]; other site
86416009642	conserved gate region; other site
86416009643	putative PBP binding loops; other site
86416009644	ABC-ATPase subunit interface; other site
86416009645	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
86416009646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009647	dimer interface [polypeptide binding]; other site
86416009648	conserved gate region; other site
86416009649	putative PBP binding loops; other site
86416009650	ABC-ATPase subunit interface; other site
86416009651	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416009652	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416009653	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416009654	DNA binding site [nucleotide binding]
86416009655	domain linker motif; other site
86416009656	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
86416009657	dimerization interface [polypeptide binding]; other site
86416009658	ligand binding site [chemical binding]; other site
86416009659	sodium binding site [ion binding]; other site
86416009660	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009661	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009662	Ca binding site [ion binding]; other site
86416009663	active site
86416009664	catalytic site [active]
86416009665	oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882
86416009666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416009667	putative substrate translocation pore; other site
86416009668	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
86416009669	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
86416009670	active site
86416009671	homodimer interface [polypeptide binding]; other site
86416009672	catalytic site [active]
86416009673	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416009674	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416009675	nucleotide binding site [chemical binding]; other site
86416009676	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009677	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009678	Ca binding site [ion binding]; other site
86416009679	active site
86416009680	catalytic site [active]
86416009681	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416009682	active pocket/dimerization site; other site
86416009683	active site
86416009684	phosphorylation site [posttranslational modification]
86416009685	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
86416009686	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
86416009687	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
86416009688	active site
86416009689	phosphorylation site [posttranslational modification]
86416009690	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
86416009691	active site
86416009692	phosphorylation site [posttranslational modification]
86416009693	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
86416009694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009695	Walker A motif; other site
86416009696	ATP binding site [chemical binding]; other site
86416009697	Walker B motif; other site
86416009698	arginine finger; other site
86416009699	Transcriptional antiterminator [Transcription]; Region: COG3933
86416009700	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416009701	active pocket/dimerization site; other site
86416009702	active site
86416009703	phosphorylation site [posttranslational modification]
86416009704	PRD domain; Region: PRD; pfam00874
86416009705	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416009706	HPr interaction site; other site
86416009707	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416009708	active site
86416009709	phosphorylation site [posttranslational modification]
86416009710	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
86416009711	HPr interaction site; other site
86416009712	glycerol kinase (GK) interaction site [polypeptide binding]; other site
86416009713	active site
86416009714	phosphorylation site [posttranslational modification]
86416009715	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416009716	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416009717	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416009718	putative active site [active]
86416009719	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
86416009720	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
86416009721	NAD binding site [chemical binding]; other site
86416009722	sugar binding site [chemical binding]; other site
86416009723	divalent metal binding site [ion binding]; other site
86416009724	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416009725	dimer interface [polypeptide binding]; other site
86416009726	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
86416009727	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
86416009728	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
86416009729	active site turn [active]
86416009730	phosphorylation site [posttranslational modification]
86416009731	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416009732	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416009733	nucleotide binding site [chemical binding]; other site
86416009734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416009735	putative Zn2+ binding site [ion binding]; other site
86416009736	putative DNA binding site [nucleotide binding]; other site
86416009737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009738	Walker A motif; other site
86416009739	ATP binding site [chemical binding]; other site
86416009740	Walker B motif; other site
86416009741	Transcriptional antiterminator [Transcription]; Region: COG3933
86416009742	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416009743	active pocket/dimerization site; other site
86416009744	active site
86416009745	phosphorylation site [posttranslational modification]
86416009746	PRD domain; Region: PRD; pfam00874
86416009747	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009748	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009749	Ca binding site [ion binding]; other site
86416009750	active site
86416009751	catalytic site [active]
86416009752	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
86416009753	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
86416009754	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
86416009755	active site
86416009756	phosphorylation site [posttranslational modification]
86416009757	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
86416009758	active pocket/dimerization site; other site
86416009759	active site
86416009760	phosphorylation site [posttranslational modification]
86416009761	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009762	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009763	Ca binding site [ion binding]; other site
86416009764	active site
86416009765	catalytic site [active]
86416009766	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416009767	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416009768	nucleotide binding site [chemical binding]; other site
86416009769	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009770	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009771	Ca binding site [ion binding]; other site
86416009772	active site
86416009773	catalytic site [active]
86416009774	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416009775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009776	dimer interface [polypeptide binding]; other site
86416009777	conserved gate region; other site
86416009778	putative PBP binding loops; other site
86416009779	ABC-ATPase subunit interface; other site
86416009780	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
86416009781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009782	dimer interface [polypeptide binding]; other site
86416009783	conserved gate region; other site
86416009784	putative PBP binding loops; other site
86416009785	ABC-ATPase subunit interface; other site
86416009786	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416009787	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416009788	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416009789	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416009790	DNA binding site [nucleotide binding]
86416009791	domain linker motif; other site
86416009792	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416009793	dimerization interface [polypeptide binding]; other site
86416009794	ligand binding site [chemical binding]; other site
86416009795	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
86416009796	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
86416009797	Ca binding site [ion binding]; other site
86416009798	active site
86416009799	catalytic site [active]
86416009800	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416009801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009802	dimer interface [polypeptide binding]; other site
86416009803	conserved gate region; other site
86416009804	putative PBP binding loops; other site
86416009805	ABC-ATPase subunit interface; other site
86416009806	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416009807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009808	dimer interface [polypeptide binding]; other site
86416009809	conserved gate region; other site
86416009810	putative PBP binding loops; other site
86416009811	ABC-ATPase subunit interface; other site
86416009812	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416009813	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
86416009814	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416009815	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416009816	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416009817	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416009818	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
86416009819	Walker A/P-loop; other site
86416009820	ATP binding site [chemical binding]; other site
86416009821	Q-loop/lid; other site
86416009822	ABC transporter signature motif; other site
86416009823	Walker B; other site
86416009824	D-loop; other site
86416009825	H-loop/switch region; other site
86416009826	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416009827	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416009828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416009829	Walker A/P-loop; other site
86416009830	ATP binding site [chemical binding]; other site
86416009831	Q-loop/lid; other site
86416009832	ABC transporter signature motif; other site
86416009833	Walker B; other site
86416009834	D-loop; other site
86416009835	H-loop/switch region; other site
86416009836	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
86416009837	Helix-turn-helix domain; Region: HTH_18; pfam12833
86416009838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416009839	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416009840	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
86416009841	MG2 domain; Region: A2M_N; pfam01835
86416009842	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
86416009843	Protein of unknown function, DUF624; Region: DUF624; pfam04854
86416009844	maltodextrin glucosidase; Provisional; Region: PRK10785
86416009845	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
86416009846	homodimer interface [polypeptide binding]; other site
86416009847	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
86416009848	active site
86416009849	homodimer interface [polypeptide binding]; other site
86416009850	catalytic site [active]
86416009851	maltose phosphorylase; Provisional; Region: PRK13807
86416009852	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
86416009853	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
86416009854	beta-phosphoglucomutase; Region: bPGM; TIGR01990
86416009855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416009856	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416009857	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416009858	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
86416009859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009860	dimer interface [polypeptide binding]; other site
86416009861	conserved gate region; other site
86416009862	putative PBP binding loops; other site
86416009863	ABC-ATPase subunit interface; other site
86416009864	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416009865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416009866	dimer interface [polypeptide binding]; other site
86416009867	conserved gate region; other site
86416009868	putative PBP binding loops; other site
86416009869	ABC-ATPase subunit interface; other site
86416009870	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
86416009871	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416009872	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416009873	Walker A/P-loop; other site
86416009874	ATP binding site [chemical binding]; other site
86416009875	Q-loop/lid; other site
86416009876	ABC transporter signature motif; other site
86416009877	Walker B; other site
86416009878	D-loop; other site
86416009879	H-loop/switch region; other site
86416009880	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416009881	4Fe-4S binding domain; Region: Fer4; pfam00037
86416009882	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416009883	4Fe-4S binding domain; Region: Fer4; pfam00037
86416009884	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
86416009885	putative FMN binding site [chemical binding]; other site
86416009886	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416009887	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416009888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416009889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416009890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416009891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
86416009892	Coenzyme A binding pocket [chemical binding]; other site
86416009893	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
86416009894	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
86416009895	active site
86416009896	NTP binding site [chemical binding]; other site
86416009897	metal binding triad [ion binding]; metal-binding site
86416009898	antibiotic binding site [chemical binding]; other site
86416009899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416009900	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416009901	dimerization interface [polypeptide binding]; other site
86416009902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416009903	dimer interface [polypeptide binding]; other site
86416009904	phosphorylation site [posttranslational modification]
86416009905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416009906	ATP binding site [chemical binding]; other site
86416009907	Mg2+ binding site [ion binding]; other site
86416009908	G-X-G motif; other site
86416009909	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416009910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416009911	active site
86416009912	phosphorylation site [posttranslational modification]
86416009913	intermolecular recognition site; other site
86416009914	dimerization interface [polypeptide binding]; other site
86416009915	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416009916	DNA binding site [nucleotide binding]
86416009917	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416009918	FtsX-like permease family; Region: FtsX; pfam02687
86416009919	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416009920	FtsX-like permease family; Region: FtsX; pfam02687
86416009921	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416009922	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416009923	Walker A/P-loop; other site
86416009924	ATP binding site [chemical binding]; other site
86416009925	Q-loop/lid; other site
86416009926	ABC transporter signature motif; other site
86416009927	Walker B; other site
86416009928	D-loop; other site
86416009929	H-loop/switch region; other site
86416009930	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
86416009931	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
86416009932	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
86416009933	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
86416009934	Rubrerythrin [Energy production and conversion]; Region: COG1592
86416009935	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
86416009936	binuclear metal center [ion binding]; other site
86416009937	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
86416009938	iron binding site [ion binding]; other site
86416009939	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
86416009940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416009941	Walker A motif; other site
86416009942	ATP binding site [chemical binding]; other site
86416009943	Walker B motif; other site
86416009944	arginine finger; other site
86416009945	Peptidase family M41; Region: Peptidase_M41; pfam01434
86416009946	Rhomboid family; Region: Rhomboid; pfam01694
86416009947	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
86416009948	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416009949	Zn2+ binding site [ion binding]; other site
86416009950	Mg2+ binding site [ion binding]; other site
86416009951	oligoendopeptidase F; Region: pepF; TIGR00181
86416009952	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
86416009953	active site
86416009954	Zn binding site [ion binding]; other site
86416009955	ferric uptake regulator; Provisional; Region: fur; PRK09462
86416009956	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
86416009957	metal binding site 2 [ion binding]; metal-binding site
86416009958	putative DNA binding helix; other site
86416009959	metal binding site 1 [ion binding]; metal-binding site
86416009960	dimer interface [polypeptide binding]; other site
86416009961	structural Zn2+ binding site [ion binding]; other site
86416009962	Predicted membrane protein [Function unknown]; Region: COG1971
86416009963	Domain of unknown function DUF; Region: DUF204; pfam02659
86416009964	Domain of unknown function DUF; Region: DUF204; pfam02659
86416009965	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
86416009966	oligomerization interface [polypeptide binding]; other site
86416009967	active site
86416009968	metal binding site [ion binding]; metal-binding site
86416009969	Pantoate-beta-alanine ligase; Region: PanC; cd00560
86416009970	pantoate--beta-alanine ligase; Region: panC; TIGR00018
86416009971	active site
86416009972	ATP-binding site [chemical binding]; other site
86416009973	pantoate-binding site; other site
86416009974	HXXH motif; other site
86416009975	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
86416009976	tetramerization interface [polypeptide binding]; other site
86416009977	active site
86416009978	amino acid transporter; Region: 2A0306; TIGR00909
86416009979	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
86416009980	EDD domain protein, DegV family; Region: DegV; TIGR00762
86416009981	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
86416009982	dipeptidase PepV; Reviewed; Region: PRK07318
86416009983	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
86416009984	active site
86416009985	metal binding site [ion binding]; metal-binding site
86416009986	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416009987	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
86416009988	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
86416009989	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
86416009990	Prephenate dehydratase; Region: PDT; pfam00800
86416009991	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
86416009992	putative L-Phe binding site [chemical binding]; other site
86416009993	2-isopropylmalate synthase; Validated; Region: PRK03739
86416009994	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
86416009995	active site
86416009996	catalytic residues [active]
86416009997	metal binding site [ion binding]; metal-binding site
86416009998	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
86416009999	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416010000	metal-binding site [ion binding]
86416010001	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416010002	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416010003	metal-binding site [ion binding]
86416010004	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416010005	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416010006	metal-binding site [ion binding]
86416010007	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416010008	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416010009	motif II; other site
86416010010	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
86416010011	putative homodimer interface [polypeptide binding]; other site
86416010012	putative homotetramer interface [polypeptide binding]; other site
86416010013	putative allosteric switch controlling residues; other site
86416010014	putative metal binding site [ion binding]; other site
86416010015	putative homodimer-homodimer interface [polypeptide binding]; other site
86416010016	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416010017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010018	active site
86416010019	phosphorylation site [posttranslational modification]
86416010020	intermolecular recognition site; other site
86416010021	dimerization interface [polypeptide binding]; other site
86416010022	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416010023	DNA binding site [nucleotide binding]
86416010024	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
86416010025	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
86416010026	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
86416010027	Ligand Binding Site [chemical binding]; other site
86416010028	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
86416010029	GAF domain; Region: GAF_3; pfam13492
86416010030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010031	phosphorylation site [posttranslational modification]
86416010032	dimer interface [polypeptide binding]; other site
86416010033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010034	ATP binding site [chemical binding]; other site
86416010035	Mg2+ binding site [ion binding]; other site
86416010036	G-X-G motif; other site
86416010037	potassium-transporting ATPase subunit C; Provisional; Region: PRK13995
86416010038	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
86416010039	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
86416010040	Soluble P-type ATPase [General function prediction only]; Region: COG4087
86416010041	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
86416010042	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
86416010043	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
86416010044	substrate binding [chemical binding]; other site
86416010045	active site
86416010046	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
86416010047	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416010048	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416010049	DNA binding site [nucleotide binding]
86416010050	domain linker motif; other site
86416010051	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
86416010052	dimerization interface [polypeptide binding]; other site
86416010053	ligand binding site [chemical binding]; other site
86416010054	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416010055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010056	dimer interface [polypeptide binding]; other site
86416010057	conserved gate region; other site
86416010058	putative PBP binding loops; other site
86416010059	ABC-ATPase subunit interface; other site
86416010060	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
86416010061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010062	dimer interface [polypeptide binding]; other site
86416010063	conserved gate region; other site
86416010064	putative PBP binding loops; other site
86416010065	ABC-ATPase subunit interface; other site
86416010066	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
86416010067	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
86416010068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416010069	S-adenosylmethionine binding site [chemical binding]; other site
86416010070	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416010071	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416010072	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416010073	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
86416010074	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
86416010075	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
86416010076	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
86416010077	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
86416010078	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
86416010079	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
86416010080	PAS domain S-box; Region: sensory_box; TIGR00229
86416010081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416010082	putative active site [active]
86416010083	heme pocket [chemical binding]; other site
86416010084	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
86416010085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416010086	Walker A motif; other site
86416010087	ATP binding site [chemical binding]; other site
86416010088	Walker B motif; other site
86416010089	arginine finger; other site
86416010090	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
86416010091	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
86416010092	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
86416010093	putative catalytic cysteine [active]
86416010094	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
86416010095	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
86416010096	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
86416010097	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
86416010098	acyl-activating enzyme (AAE) consensus motif; other site
86416010099	acyl-activating enzyme (AAE) consensus motif; other site
86416010100	putative AMP binding site [chemical binding]; other site
86416010101	putative active site [active]
86416010102	putative CoA binding site [chemical binding]; other site
86416010103	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
86416010104	Uncharacterized conserved protein [Function unknown]; Region: COG1359
86416010105	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
86416010106	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
86416010107	dimer interface [polypeptide binding]; other site
86416010108	active site
86416010109	metal binding site [ion binding]; metal-binding site
86416010110	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
86416010111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010112	putative substrate translocation pore; other site
86416010113	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
86416010114	4Fe-4S binding domain; Region: Fer4; cl02805
86416010115	4Fe-4S binding domain; Region: Fer4; pfam00037
86416010116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010117	FeS/SAM binding site; other site
86416010118	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
86416010119	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
86416010120	dimer interface [polypeptide binding]; other site
86416010121	active site
86416010122	glycine loop; other site
86416010123	6-phosphofructokinase; Provisional; Region: PRK03202
86416010124	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
86416010125	active site
86416010126	ADP/pyrophosphate binding site [chemical binding]; other site
86416010127	dimerization interface [polypeptide binding]; other site
86416010128	allosteric effector site; other site
86416010129	fructose-1,6-bisphosphate binding site; other site
86416010130	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
86416010131	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
86416010132	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010133	FeS/SAM binding site; other site
86416010134	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
86416010135	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
86416010136	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416010137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010138	putative substrate translocation pore; other site
86416010139	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
86416010140	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
86416010141	NAD(P) binding site [chemical binding]; other site
86416010142	catalytic residues [active]
86416010143	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
86416010144	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
86416010145	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
86416010146	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
86416010147	NAD(P) binding site [chemical binding]; other site
86416010148	catalytic residues [active]
86416010149	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
86416010150	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
86416010151	substrate binding site [chemical binding]; other site
86416010152	hexamer interface [polypeptide binding]; other site
86416010153	metal binding site [ion binding]; metal-binding site
86416010154	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
86416010155	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
86416010156	NAD(P) binding site [chemical binding]; other site
86416010157	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
86416010158	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
86416010159	PYR/PP interface [polypeptide binding]; other site
86416010160	dimer interface [polypeptide binding]; other site
86416010161	TPP binding site [chemical binding]; other site
86416010162	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416010163	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
86416010164	transketolase; Reviewed; Region: PRK05899
86416010165	TPP-binding site [chemical binding]; other site
86416010166	dimer interface [polypeptide binding]; other site
86416010167	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416010168	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
86416010169	active site
86416010170	NAD binding site [chemical binding]; other site
86416010171	metal binding site [ion binding]; metal-binding site
86416010172	Uncharacterized conserved protein [Function unknown]; Region: COG1359
86416010173	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416010174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
86416010175	dimerization interface [polypeptide binding]; other site
86416010176	putative DNA binding site [nucleotide binding]; other site
86416010177	putative Zn2+ binding site [ion binding]; other site
86416010178	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
86416010179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010180	putative substrate translocation pore; other site
86416010181	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
86416010182	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
86416010183	catalytic residues [active]
86416010184	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
86416010185	active site
86416010186	zinc binding site [ion binding]; other site
86416010187	Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327
86416010188	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
86416010189	Survival protein SurE; Region: SurE; cl00448
86416010190	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416010191	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416010192	dimer interface [polypeptide binding]; other site
86416010193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010194	catalytic residue [active]
86416010195	cystathionine beta-lyase; Provisional; Region: PRK07671
86416010196	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416010197	homodimer interface [polypeptide binding]; other site
86416010198	substrate-cofactor binding pocket; other site
86416010199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010200	catalytic residue [active]
86416010201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416010202	S-adenosylmethionine binding site [chemical binding]; other site
86416010203	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
86416010204	metal binding site [ion binding]; metal-binding site
86416010205	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
86416010206	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416010207	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416010208	Coenzyme A binding pocket [chemical binding]; other site
86416010209	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
86416010210	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
86416010211	substrate binding site [chemical binding]; other site
86416010212	glutamase interaction surface [polypeptide binding]; other site
86416010213	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
86416010214	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416010215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010216	homodimer interface [polypeptide binding]; other site
86416010217	catalytic residue [active]
86416010218	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
86416010219	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
86416010220	catalytic residues [active]
86416010221	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
86416010222	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
86416010223	putative active site [active]
86416010224	oxyanion strand; other site
86416010225	catalytic triad [active]
86416010226	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
86416010227	putative active site pocket [active]
86416010228	4-fold oligomerization interface [polypeptide binding]; other site
86416010229	metal binding residues [ion binding]; metal-binding site
86416010230	3-fold/trimer interface [polypeptide binding]; other site
86416010231	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
86416010232	histidinol dehydrogenase; Region: hisD; TIGR00069
86416010233	NAD binding site [chemical binding]; other site
86416010234	dimerization interface [polypeptide binding]; other site
86416010235	product binding site; other site
86416010236	substrate binding site [chemical binding]; other site
86416010237	zinc binding site [ion binding]; other site
86416010238	catalytic residues [active]
86416010239	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
86416010240	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
86416010241	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
86416010242	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
86416010243	dimer interface [polypeptide binding]; other site
86416010244	motif 1; other site
86416010245	active site
86416010246	motif 2; other site
86416010247	motif 3; other site
86416010248	histidinol-phosphatase; Provisional; Region: PRK05588
86416010249	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
86416010250	active site
86416010251	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
86416010252	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416010253	putative active site [active]
86416010254	heme pocket [chemical binding]; other site
86416010255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010256	dimer interface [polypeptide binding]; other site
86416010257	phosphorylation site [posttranslational modification]
86416010258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010259	ATP binding site [chemical binding]; other site
86416010260	Mg2+ binding site [ion binding]; other site
86416010261	G-X-G motif; other site
86416010262	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
86416010263	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
86416010264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
86416010265	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
86416010266	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
86416010267	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
86416010268	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
86416010269	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416010270	catalytic residue [active]
86416010271	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
86416010272	heat shock protein 90; Provisional; Region: PRK05218
86416010273	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
86416010274	ATP binding site [chemical binding]; other site
86416010275	Mg2+ binding site [ion binding]; other site
86416010276	G-X-G motif; other site
86416010277	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
86416010278	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
86416010279	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
86416010280	putative substrate binding site [chemical binding]; other site
86416010281	putative ATP binding site [chemical binding]; other site
86416010282	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416010283	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416010284	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
86416010285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
86416010286	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
86416010287	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
86416010288	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
86416010289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416010290	NAD(P) binding site [chemical binding]; other site
86416010291	active site
86416010292	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
86416010293	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
86416010294	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
86416010295	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
86416010296	active site
86416010297	ATP binding site [chemical binding]; other site
86416010298	substrate binding site [chemical binding]; other site
86416010299	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
86416010300	aspartate kinase I; Reviewed; Region: PRK08210
86416010301	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
86416010302	nucleotide binding site [chemical binding]; other site
86416010303	substrate binding site [chemical binding]; other site
86416010304	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
86416010305	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
86416010306	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
86416010307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
86416010308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010309	dimer interface [polypeptide binding]; other site
86416010310	phosphorylation site [posttranslational modification]
86416010311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010312	ATP binding site [chemical binding]; other site
86416010313	Mg2+ binding site [ion binding]; other site
86416010314	G-X-G motif; other site
86416010315	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
86416010316	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416010317	S-adenosylmethionine binding site [chemical binding]; other site
86416010318	monogalactosyldiacylglycerol synthase; Region: PLN02605
86416010319	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
86416010320	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
86416010321	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
86416010322	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
86416010323	ATP binding site [chemical binding]; other site
86416010324	Mg++ binding site [ion binding]; other site
86416010325	motif III; other site
86416010326	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416010327	nucleotide binding region [chemical binding]; other site
86416010328	ATP-binding site [chemical binding]; other site
86416010329	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
86416010330	RNA binding site [nucleotide binding]; other site
86416010331	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
86416010332	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
86416010333	Ligand Binding Site [chemical binding]; other site
86416010334	helicase 45; Provisional; Region: PTZ00424
86416010335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
86416010336	ATP binding site [chemical binding]; other site
86416010337	putative Mg++ binding site [ion binding]; other site
86416010338	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416010339	nucleotide binding region [chemical binding]; other site
86416010340	ATP-binding site [chemical binding]; other site
86416010341	hypothetical protein; Validated; Region: PRK07682
86416010342	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416010343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010344	homodimer interface [polypeptide binding]; other site
86416010345	catalytic residue [active]
86416010346	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
86416010347	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
86416010348	AsnC family; Region: AsnC_trans_reg; pfam01037
86416010349	Uncharacterized conserved protein [Function unknown]; Region: COG3874
86416010350	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
86416010351	PAS domain; Region: PAS; smart00091
86416010352	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
86416010353	putative active site [active]
86416010354	heme pocket [chemical binding]; other site
86416010355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010356	dimer interface [polypeptide binding]; other site
86416010357	phosphorylation site [posttranslational modification]
86416010358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010359	ATP binding site [chemical binding]; other site
86416010360	Mg2+ binding site [ion binding]; other site
86416010361	G-X-G motif; other site
86416010362	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
86416010363	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
86416010364	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
86416010365	Ligand Binding Site [chemical binding]; other site
86416010366	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
86416010367	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
86416010368	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
86416010369	active site
86416010370	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
86416010371	QueT transporter; Region: QueT; pfam06177
86416010372	MATE family multidrug exporter; Provisional; Region: PRK10189
86416010373	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
86416010374	Glucose inhibited division protein A; Region: GIDA; pfam01134
86416010375	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416010376	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
86416010377	SpoVR like protein; Region: SpoVR; pfam04293
86416010378	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
86416010379	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
86416010380	metal ion-dependent adhesion site (MIDAS); other site
86416010381	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
86416010382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
86416010383	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
86416010384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010385	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416010386	putative substrate translocation pore; other site
86416010387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010388	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416010389	MarR family; Region: MarR_2; pfam12802
86416010390	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
86416010391	catalytic core [active]
86416010392	cobalamin synthase; Reviewed; Region: cobS; PRK00235
86416010393	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
86416010394	homotrimer interface [polypeptide binding]; other site
86416010395	Walker A motif; other site
86416010396	GTP binding site [chemical binding]; other site
86416010397	Walker B motif; other site
86416010398	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
86416010399	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
86416010400	active site pocket [active]
86416010401	putative dimer interface [polypeptide binding]; other site
86416010402	putative cataytic base [active]
86416010403	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
86416010404	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
86416010405	metal binding site [ion binding]; metal-binding site
86416010406	putative dimer interface [polypeptide binding]; other site
86416010407	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416010408	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416010409	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
86416010410	Walker A/P-loop; other site
86416010411	ATP binding site [chemical binding]; other site
86416010412	Q-loop/lid; other site
86416010413	ABC transporter signature motif; other site
86416010414	Walker B; other site
86416010415	D-loop; other site
86416010416	H-loop/switch region; other site
86416010417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416010419	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
86416010420	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
86416010421	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
86416010422	thiamine phosphate binding site [chemical binding]; other site
86416010423	active site
86416010424	pyrophosphate binding site [ion binding]; other site
86416010425	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
86416010426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010427	FeS/SAM binding site; other site
86416010428	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
86416010429	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
86416010430	ThiS interaction site; other site
86416010431	putative active site [active]
86416010432	tetramer interface [polypeptide binding]; other site
86416010433	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
86416010434	thiS-thiF/thiG interaction site; other site
86416010435	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
86416010436	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
86416010437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
86416010438	Tetratricopeptide repeat; Region: TPR_12; pfam13424
86416010439	Tetratricopeptide repeat; Region: TPR_12; pfam13424
86416010440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416010441	binding surface
86416010442	TPR motif; other site
86416010443	Tetratricopeptide repeat; Region: TPR_12; pfam13424
86416010444	GAF domain; Region: GAF_2; pfam13185
86416010445	GAF domain; Region: GAF; pfam01590
86416010446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
86416010447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
86416010448	metal binding site [ion binding]; metal-binding site
86416010449	active site
86416010450	I-site; other site
86416010451	monoglyceride lipase; Provisional; Region: PHA02857
86416010452	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
86416010453	MoxR-like ATPases [General function prediction only]; Region: COG0714
86416010454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416010455	Walker A motif; other site
86416010456	ATP binding site [chemical binding]; other site
86416010457	Walker B motif; other site
86416010458	arginine finger; other site
86416010459	Protein of unknown function DUF58; Region: DUF58; pfam01882
86416010460	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
86416010461	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
86416010462	GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323
86416010463	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
86416010464	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010465	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010466	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010467	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010469	FeS/SAM binding site; other site
86416010470	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416010471	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416010472	Walker A/P-loop; other site
86416010473	ATP binding site [chemical binding]; other site
86416010474	Q-loop/lid; other site
86416010475	ABC transporter signature motif; other site
86416010476	Walker B; other site
86416010477	D-loop; other site
86416010478	H-loop/switch region; other site
86416010479	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416010480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010481	dimer interface [polypeptide binding]; other site
86416010482	conserved gate region; other site
86416010483	putative PBP binding loops; other site
86416010484	ABC-ATPase subunit interface; other site
86416010485	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416010486	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416010487	substrate binding pocket [chemical binding]; other site
86416010488	membrane-bound complex binding site; other site
86416010489	hinge residues; other site
86416010490	anaerobic sulfatase-maturase; Provisional; Region: PRK13758
86416010491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010492	FeS/SAM binding site; other site
86416010493	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
86416010494	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416010495	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416010496	Walker A/P-loop; other site
86416010497	ATP binding site [chemical binding]; other site
86416010498	Q-loop/lid; other site
86416010499	ABC transporter signature motif; other site
86416010500	Walker B; other site
86416010501	D-loop; other site
86416010502	H-loop/switch region; other site
86416010503	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416010504	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010505	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416010506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010507	dimer interface [polypeptide binding]; other site
86416010508	conserved gate region; other site
86416010509	putative PBP binding loops; other site
86416010510	ABC-ATPase subunit interface; other site
86416010511	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416010512	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416010513	Walker A/P-loop; other site
86416010514	ATP binding site [chemical binding]; other site
86416010515	Q-loop/lid; other site
86416010516	ABC transporter signature motif; other site
86416010517	Walker B; other site
86416010518	D-loop; other site
86416010519	H-loop/switch region; other site
86416010520	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416010521	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010522	S-adenosylmethionine synthetase; Validated; Region: PRK05250
86416010523	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
86416010524	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
86416010525	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
86416010526	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
86416010527	nitrogenase iron protein; Region: nifH; TIGR01287
86416010528	Sulfatase; Region: Sulfatase; cl17466
86416010529	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
86416010530	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
86416010531	NAD binding site [chemical binding]; other site
86416010532	ligand binding site [chemical binding]; other site
86416010533	catalytic site [active]
86416010534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416010535	Coenzyme A binding pocket [chemical binding]; other site
86416010536	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416010537	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416010538	substrate binding pocket [chemical binding]; other site
86416010539	membrane-bound complex binding site; other site
86416010540	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
86416010541	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416010542	active site
86416010543	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
86416010544	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
86416010545	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
86416010546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
86416010547	NAD(P) binding site [chemical binding]; other site
86416010548	active site
86416010549	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
86416010550	Transposase, Mutator family; Region: Transposase_mut; pfam00872
86416010551	MULE transposase domain; Region: MULE; pfam10551
86416010552	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
86416010553	Radical SAM superfamily; Region: Radical_SAM; pfam04055
86416010554	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
86416010555	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
86416010556	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
86416010557	FMN binding site [chemical binding]; other site
86416010558	dimer interface [polypeptide binding]; other site
86416010559	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
86416010560	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010561	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010562	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
86416010563	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416010564	Walker A/P-loop; other site
86416010565	ATP binding site [chemical binding]; other site
86416010566	Q-loop/lid; other site
86416010567	ABC transporter signature motif; other site
86416010568	Walker B; other site
86416010569	D-loop; other site
86416010570	H-loop/switch region; other site
86416010571	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
86416010572	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
86416010573	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
86416010574	Walker A/P-loop; other site
86416010575	ATP binding site [chemical binding]; other site
86416010576	Q-loop/lid; other site
86416010577	ABC transporter signature motif; other site
86416010578	Walker B; other site
86416010579	D-loop; other site
86416010580	H-loop/switch region; other site
86416010581	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
86416010582	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
86416010583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010584	dimer interface [polypeptide binding]; other site
86416010585	conserved gate region; other site
86416010586	putative PBP binding loops; other site
86416010587	ABC-ATPase subunit interface; other site
86416010588	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
86416010589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010590	putative PBP binding loops; other site
86416010591	dimer interface [polypeptide binding]; other site
86416010592	ABC-ATPase subunit interface; other site
86416010593	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
86416010594	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
86416010595	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
86416010596	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
86416010597	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
86416010598	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
86416010599	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
86416010600	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
86416010601	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416010602	homodimer interface [polypeptide binding]; other site
86416010603	substrate-cofactor binding pocket; other site
86416010604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010605	catalytic residue [active]
86416010606	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010607	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010608	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010609	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010610	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
86416010611	nitrogenase iron protein; Region: nifH; TIGR01287
86416010612	Nucleotide-binding sites [chemical binding]; other site
86416010613	Walker A motif; other site
86416010614	Switch I region of nucleotide binding site; other site
86416010615	Fe4S4 binding sites [ion binding]; other site
86416010616	Switch II region of nucleotide binding site; other site
86416010617	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
86416010618	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
86416010619	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
86416010620	metal binding site [ion binding]; metal-binding site
86416010621	dimer interface [polypeptide binding]; other site
86416010622	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
86416010623	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
86416010624	active site
86416010625	NAD binding site [chemical binding]; other site
86416010626	metal binding site [ion binding]; metal-binding site
86416010627	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
86416010628	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416010629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010630	homodimer interface [polypeptide binding]; other site
86416010631	catalytic residue [active]
86416010632	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010633	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010634	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010635	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010637	Radical SAM superfamily; Region: Radical_SAM; pfam04055
86416010638	FeS/SAM binding site; other site
86416010639	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
86416010640	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416010641	homodimer interface [polypeptide binding]; other site
86416010642	substrate-cofactor binding pocket; other site
86416010643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010644	catalytic residue [active]
86416010645	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416010646	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416010647	dimer interface [polypeptide binding]; other site
86416010648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010649	catalytic residue [active]
86416010650	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416010651	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416010652	Walker A/P-loop; other site
86416010653	ATP binding site [chemical binding]; other site
86416010654	Q-loop/lid; other site
86416010655	ABC transporter signature motif; other site
86416010656	Walker B; other site
86416010657	D-loop; other site
86416010658	H-loop/switch region; other site
86416010659	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416010660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010661	dimer interface [polypeptide binding]; other site
86416010662	conserved gate region; other site
86416010663	putative PBP binding loops; other site
86416010664	ABC-ATPase subunit interface; other site
86416010665	Family description; Region: DsbD_2; pfam13386
86416010666	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
86416010667	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
86416010668	4Fe-4S binding domain; Region: Fer4_5; pfam12801
86416010669	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
86416010670	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416010671	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416010672	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010673	NMT1/THI5 like; Region: NMT1; pfam09084
86416010674	NMT1/THI5 like; Region: NMT1; pfam09084
86416010675	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010676	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010677	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
86416010678	NMT1/THI5 like; Region: NMT1; pfam09084
86416010679	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
86416010680	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
86416010681	metal-binding site [ion binding]
86416010682	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
86416010683	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
86416010684	dimer interface [polypeptide binding]; other site
86416010685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010686	catalytic residue [active]
86416010687	two-component sensor protein; Provisional; Region: cpxA; PRK09470
86416010688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416010689	dimerization interface [polypeptide binding]; other site
86416010690	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010691	dimer interface [polypeptide binding]; other site
86416010692	phosphorylation site [posttranslational modification]
86416010693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010694	ATP binding site [chemical binding]; other site
86416010695	Mg2+ binding site [ion binding]; other site
86416010696	G-X-G motif; other site
86416010697	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416010698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010699	active site
86416010700	phosphorylation site [posttranslational modification]
86416010701	intermolecular recognition site; other site
86416010702	dimerization interface [polypeptide binding]; other site
86416010703	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416010704	DNA binding site [nucleotide binding]
86416010705	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
86416010706	Nitrogen regulatory protein P-II; Region: P-II; smart00938
86416010707	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
86416010708	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010709	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010710	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010711	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010712	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
86416010713	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
86416010714	putative ligand binding site [chemical binding]; other site
86416010715	putative NAD binding site [chemical binding]; other site
86416010716	catalytic site [active]
86416010717	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
86416010718	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
86416010719	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416010720	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
86416010721	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
86416010722	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416010723	Cupin domain; Region: Cupin_2; pfam07883
86416010724	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
86416010725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416010726	active site
86416010727	motif I; other site
86416010728	motif II; other site
86416010729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416010730	aspartate aminotransferase; Provisional; Region: PRK06348
86416010731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416010732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416010733	homodimer interface [polypeptide binding]; other site
86416010734	catalytic residue [active]
86416010735	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
86416010736	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
86416010737	Amidinotransferase; Region: Amidinotransf; pfam02274
86416010738	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416010739	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416010740	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416010741	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
86416010742	putative active site [active]
86416010743	metal binding site [ion binding]; metal-binding site
86416010744	4Fe-4S binding domain; Region: Fer4; pfam00037
86416010745	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
86416010746	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
86416010747	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
86416010748	active site
86416010749	intersubunit interactions; other site
86416010750	catalytic residue [active]
86416010751	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010752	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010753	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416010754	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416010755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416010756	FeS/SAM binding site; other site
86416010757	Radical SAM superfamily; Region: Radical_SAM; pfam04055
86416010758	4Fe-4S binding domain; Region: Fer4_5; pfam12801
86416010759	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416010760	FMN-binding domain; Region: FMN_bind; cl01081
86416010761	MOSC domain; Region: MOSC; pfam03473
86416010762	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
86416010763	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
86416010764	dimer interface [polypeptide binding]; other site
86416010765	putative functional site; other site
86416010766	putative MPT binding site; other site
86416010767	PBP superfamily domain; Region: PBP_like; pfam12727
86416010768	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
86416010769	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
86416010770	dimer interface [polypeptide binding]; other site
86416010771	putative functional site; other site
86416010772	putative MPT binding site; other site
86416010773	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
86416010774	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
86416010775	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
86416010776	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
86416010777	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
86416010778	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
86416010779	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
86416010780	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
86416010781	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
86416010782	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
86416010783	molybdopterin cofactor binding site; other site
86416010784	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
86416010785	molybdopterin cofactor binding site; other site
86416010786	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
86416010787	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
86416010788	molybdopterin cofactor binding site; other site
86416010789	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
86416010790	molybdopterin cofactor binding site; other site
86416010791	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
86416010792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416010793	Walker A motif; other site
86416010794	ATP binding site [chemical binding]; other site
86416010795	Walker B motif; other site
86416010796	arginine finger; other site
86416010797	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
86416010798	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
86416010799	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416010800	MarR family; Region: MarR; pfam01047
86416010801	Uncharacterized conserved protein [Function unknown]; Region: COG2898
86416010802	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
86416010803	short chain dehydrogenase; Provisional; Region: PRK12939
86416010804	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
86416010805	NADP binding site [chemical binding]; other site
86416010806	homodimer interface [polypeptide binding]; other site
86416010807	active site
86416010808	substrate binding site [chemical binding]; other site
86416010809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416010810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416010811	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416010812	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416010813	active site
86416010814	catalytic tetrad [active]
86416010815	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416010816	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416010817	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416010818	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416010819	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
86416010820	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
86416010821	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
86416010822	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
86416010823	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
86416010824	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
86416010825	putative active site [active]
86416010826	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
86416010827	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416010828	active site
86416010829	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
86416010830	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
86416010831	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
86416010832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416010833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416010834	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
86416010835	putative dimerization interface [polypeptide binding]; other site
86416010836	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
86416010837	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416010838	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
86416010839	Walker A/P-loop; other site
86416010840	ATP binding site [chemical binding]; other site
86416010841	Q-loop/lid; other site
86416010842	ABC transporter signature motif; other site
86416010843	Walker B; other site
86416010844	D-loop; other site
86416010845	H-loop/switch region; other site
86416010846	YceG-like family; Region: YceG; pfam02618
86416010847	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
86416010848	dimerization interface [polypeptide binding]; other site
86416010849	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
86416010850	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
86416010851	active site
86416010852	NAD binding site [chemical binding]; other site
86416010853	metal binding site [ion binding]; metal-binding site
86416010854	acetolactate synthase; Reviewed; Region: PRK08322
86416010855	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
86416010856	PYR/PP interface [polypeptide binding]; other site
86416010857	dimer interface [polypeptide binding]; other site
86416010858	TPP binding site [chemical binding]; other site
86416010859	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
86416010860	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
86416010861	TPP-binding site [chemical binding]; other site
86416010862	dimer interface [polypeptide binding]; other site
86416010863	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
86416010864	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
86416010865	Walker A/P-loop; other site
86416010866	ATP binding site [chemical binding]; other site
86416010867	Q-loop/lid; other site
86416010868	ABC transporter signature motif; other site
86416010869	Walker B; other site
86416010870	D-loop; other site
86416010871	H-loop/switch region; other site
86416010872	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
86416010873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416010874	dimer interface [polypeptide binding]; other site
86416010875	conserved gate region; other site
86416010876	putative PBP binding loops; other site
86416010877	ABC-ATPase subunit interface; other site
86416010878	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
86416010879	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416010880	substrate binding pocket [chemical binding]; other site
86416010881	membrane-bound complex binding site; other site
86416010882	hinge residues; other site
86416010883	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
86416010884	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
86416010885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416010886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010887	ATP binding site [chemical binding]; other site
86416010888	Mg2+ binding site [ion binding]; other site
86416010889	G-X-G motif; other site
86416010890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010891	Response regulator receiver domain; Region: Response_reg; pfam00072
86416010892	active site
86416010893	phosphorylation site [posttranslational modification]
86416010894	intermolecular recognition site; other site
86416010895	dimerization interface [polypeptide binding]; other site
86416010896	YcbB domain; Region: YcbB; pfam08664
86416010897	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
86416010898	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
86416010899	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
86416010900	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416010901	dimerization interface [polypeptide binding]; other site
86416010902	GAF domain; Region: GAF_3; pfam13492
86416010903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416010904	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010905	dimer interface [polypeptide binding]; other site
86416010906	phosphorylation site [posttranslational modification]
86416010907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010908	ATP binding site [chemical binding]; other site
86416010909	Mg2+ binding site [ion binding]; other site
86416010910	G-X-G motif; other site
86416010911	Response regulator receiver domain; Region: Response_reg; pfam00072
86416010912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010913	active site
86416010914	phosphorylation site [posttranslational modification]
86416010915	intermolecular recognition site; other site
86416010916	dimerization interface [polypeptide binding]; other site
86416010917	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
86416010918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010919	active site
86416010920	phosphorylation site [posttranslational modification]
86416010921	intermolecular recognition site; other site
86416010922	dimerization interface [polypeptide binding]; other site
86416010923	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
86416010924	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
86416010925	putative ligand binding site [chemical binding]; other site
86416010926	Response regulator receiver domain; Region: Response_reg; pfam00072
86416010927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416010928	active site
86416010929	phosphorylation site [posttranslational modification]
86416010930	intermolecular recognition site; other site
86416010931	dimerization interface [polypeptide binding]; other site
86416010932	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416010933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416010934	dimer interface [polypeptide binding]; other site
86416010935	phosphorylation site [posttranslational modification]
86416010936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416010937	ATP binding site [chemical binding]; other site
86416010938	Mg2+ binding site [ion binding]; other site
86416010939	G-X-G motif; other site
86416010940	4Fe-4S binding domain; Region: Fer4; pfam00037
86416010941	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416010942	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
86416010943	FMN binding site [chemical binding]; other site
86416010944	dimer interface [polypeptide binding]; other site
86416010945	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
86416010946	myosin-cross-reactive antigen; Provisional; Region: PRK13977
86416010947	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
86416010948	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
86416010949	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
86416010950	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
86416010951	Winged helix-turn helix; Region: HTH_29; pfam13551
86416010952	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
86416010953	CHC2 zinc finger; Region: zf-CHC2; cl17510
86416010954	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
86416010955	active site
86416010956	metal binding site [ion binding]; metal-binding site
86416010957	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
86416010958	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
86416010959	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416010960	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416010961	dimer interface [polypeptide binding]; other site
86416010962	ssDNA binding site [nucleotide binding]; other site
86416010963	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416010964	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
86416010965	proteasome-activating nucleotidase; Provisional; Region: PRK03992
86416010966	RecT family; Region: RecT; cl04285
86416010967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416010968	AAA domain; Region: AAA_23; pfam13476
86416010969	Walker A/P-loop; other site
86416010970	ATP binding site [chemical binding]; other site
86416010971	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
86416010972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416010973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
86416010974	DNA binding residues [nucleotide binding]
86416010975	Helix-turn-helix domain; Region: HTH_17; pfam12728
86416010976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416010977	non-specific DNA binding site [nucleotide binding]; other site
86416010978	salt bridge; other site
86416010979	sequence-specific DNA binding site [nucleotide binding]; other site
86416010980	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
86416010981	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
86416010982	Int/Topo IB signature motif; other site
86416010983	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
86416010984	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
86416010985	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
86416010986	intersubunit interface [polypeptide binding]; other site
86416010987	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416010988	Zn2+ binding site [ion binding]; other site
86416010989	Mg2+ binding site [ion binding]; other site
86416010990	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
86416010991	Zn2+ binding site [ion binding]; other site
86416010992	Mg2+ binding site [ion binding]; other site
86416010993	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
86416010994	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
86416010995	Glycoprotease family; Region: Peptidase_M22; pfam00814
86416010996	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
86416010997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416010998	Coenzyme A binding pocket [chemical binding]; other site
86416010999	Predicted membrane protein [Function unknown]; Region: COG3601
86416011000	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
86416011001	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
86416011002	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
86416011003	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
86416011004	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
86416011005	RNA binding site [nucleotide binding]; other site
86416011006	Protein of unknown function (DUF975); Region: DUF975; cl10504
86416011007	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
86416011008	Domain of unknown function DUF21; Region: DUF21; pfam01595
86416011009	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
86416011010	Transporter associated domain; Region: CorC_HlyC; smart01091
86416011011	Predicted transcriptional regulators [Transcription]; Region: COG1733
86416011012	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
86416011013	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
86416011014	putative FMN binding site [chemical binding]; other site
86416011015	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
86416011016	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
86416011017	nucleotide binding site/active site [active]
86416011018	HIT family signature motif; other site
86416011019	catalytic residue [active]
86416011020	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
86416011021	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
86416011022	inhibitor-cofactor binding pocket; inhibition site
86416011023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416011024	catalytic residue [active]
86416011025	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
86416011026	active site
86416011027	SAM binding site [chemical binding]; other site
86416011028	homodimer interface [polypeptide binding]; other site
86416011029	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
86416011030	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
86416011031	active site
86416011032	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
86416011033	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
86416011034	domain interfaces; other site
86416011035	active site
86416011036	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
86416011037	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
86416011038	tRNA; other site
86416011039	putative tRNA binding site [nucleotide binding]; other site
86416011040	putative NADP binding site [chemical binding]; other site
86416011041	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
86416011042	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
86416011043	CysD dimerization site [polypeptide binding]; other site
86416011044	G1 box; other site
86416011045	putative GEF interaction site [polypeptide binding]; other site
86416011046	GTP/Mg2+ binding site [chemical binding]; other site
86416011047	Switch I region; other site
86416011048	G2 box; other site
86416011049	G3 box; other site
86416011050	Switch II region; other site
86416011051	G4 box; other site
86416011052	G5 box; other site
86416011053	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
86416011054	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
86416011055	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
86416011056	active site
86416011057	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
86416011058	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
86416011059	Active Sites [active]
86416011060	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
86416011061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
86416011062	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
86416011063	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
86416011064	Walker A/P-loop; other site
86416011065	ATP binding site [chemical binding]; other site
86416011066	Q-loop/lid; other site
86416011067	ABC transporter signature motif; other site
86416011068	Walker B; other site
86416011069	D-loop; other site
86416011070	H-loop/switch region; other site
86416011071	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
86416011072	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416011073	substrate binding pocket [chemical binding]; other site
86416011074	membrane-bound complex binding site; other site
86416011075	hinge residues; other site
86416011076	Ferredoxin [Energy production and conversion]; Region: COG1146
86416011077	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
86416011078	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
86416011079	L-aspartate oxidase; Provisional; Region: PRK06175
86416011080	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
86416011081	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
86416011082	ligand-binding site [chemical binding]; other site
86416011083	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
86416011084	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
86416011085	homodimer interface [polypeptide binding]; other site
86416011086	substrate-cofactor binding pocket; other site
86416011087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416011088	catalytic residue [active]
86416011089	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
86416011090	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
86416011091	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
86416011092	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
86416011093	CPxP  motif; other site
86416011094	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
86416011095	MPN+ (JAMM) motif; other site
86416011096	Zinc-binding site [ion binding]; other site
86416011097	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
86416011098	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
86416011099	ATP binding site [chemical binding]; other site
86416011100	substrate interface [chemical binding]; other site
86416011101	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
86416011102	thiS-thiF/thiG interaction site; other site
86416011103	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
86416011104	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
86416011105	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416011106	nucleotide binding site [chemical binding]; other site
86416011107	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
86416011108	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
86416011109	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
86416011110	peptide chain release factor 2; Provisional; Region: PRK05589
86416011111	PCRF domain; Region: PCRF; pfam03462
86416011112	RF-1 domain; Region: RF-1; pfam00472
86416011113	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
86416011114	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
86416011115	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416011116	nucleotide binding region [chemical binding]; other site
86416011117	ATP-binding site [chemical binding]; other site
86416011118	SEC-C motif; Region: SEC-C; pfam02810
86416011119	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
86416011120	30S subunit binding site; other site
86416011121	comF family protein; Region: comF; TIGR00201
86416011122	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416011123	active site
86416011124	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
86416011125	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
86416011126	AAA domain; Region: AAA_30; pfam13604
86416011127	Family description; Region: UvrD_C_2; pfam13538
86416011128	S-adenosylmethionine synthetase; Validated; Region: PRK05250
86416011129	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
86416011130	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
86416011131	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
86416011132	Protein of unknown function (DUF1256); Region: DUF1256; pfam06866
86416011133	rod shape-determining protein Mbl; Provisional; Region: PRK13928
86416011134	MreB and similar proteins; Region: MreB_like; cd10225
86416011135	nucleotide binding site [chemical binding]; other site
86416011136	Mg binding site [ion binding]; other site
86416011137	putative protofilament interaction site [polypeptide binding]; other site
86416011138	RodZ interaction site [polypeptide binding]; other site
86416011139	Stage III sporulation protein D; Region: SpoIIID; pfam12116
86416011140	Peptidase family M23; Region: Peptidase_M23; pfam01551
86416011141	stage II sporulation protein D; Region: spore_II_D; TIGR02870
86416011142	Stage II sporulation protein; Region: SpoIID; pfam08486
86416011143	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
86416011144	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
86416011145	hinge; other site
86416011146	active site
86416011147	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
86416011148	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
86416011149	gamma subunit interface [polypeptide binding]; other site
86416011150	epsilon subunit interface [polypeptide binding]; other site
86416011151	LBP interface [polypeptide binding]; other site
86416011152	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
86416011153	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
86416011154	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
86416011155	alpha subunit interaction interface [polypeptide binding]; other site
86416011156	Walker A motif; other site
86416011157	ATP binding site [chemical binding]; other site
86416011158	Walker B motif; other site
86416011159	inhibitor binding site; inhibition site
86416011160	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
86416011161	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
86416011162	core domain interface [polypeptide binding]; other site
86416011163	delta subunit interface [polypeptide binding]; other site
86416011164	epsilon subunit interface [polypeptide binding]; other site
86416011165	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
86416011166	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
86416011167	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
86416011168	beta subunit interaction interface [polypeptide binding]; other site
86416011169	Walker A motif; other site
86416011170	ATP binding site [chemical binding]; other site
86416011171	Walker B motif; other site
86416011172	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
86416011173	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
86416011174	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
86416011175	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
86416011176	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
86416011177	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
86416011178	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
86416011179	putative acyltransferase; Provisional; Region: PRK05790
86416011180	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
86416011181	dimer interface [polypeptide binding]; other site
86416011182	active site
86416011183	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
86416011184	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
86416011185	active site
86416011186	homodimer interface [polypeptide binding]; other site
86416011187	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
86416011188	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
86416011189	Mg++ binding site [ion binding]; other site
86416011190	putative catalytic motif [active]
86416011191	substrate binding site [chemical binding]; other site
86416011192	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
86416011193	active site
86416011194	Zn binding site [ion binding]; other site
86416011195	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
86416011196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416011197	Walker A/P-loop; other site
86416011198	ATP binding site [chemical binding]; other site
86416011199	Q-loop/lid; other site
86416011200	ABC transporter signature motif; other site
86416011201	Walker B; other site
86416011202	D-loop; other site
86416011203	H-loop/switch region; other site
86416011204	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
86416011205	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
86416011206	ABC-ATPase subunit  interface; other site
86416011207	dimer interface [polypeptide binding]; other site
86416011208	putative PBP binding regions; other site
86416011209	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
86416011210	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
86416011211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
86416011212	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
86416011213	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
86416011214	oligomer interface [polypeptide binding]; other site
86416011215	metal binding site [ion binding]; metal-binding site
86416011216	metal binding site [ion binding]; metal-binding site
86416011217	putative Cl binding site [ion binding]; other site
86416011218	aspartate ring; other site
86416011219	basic sphincter; other site
86416011220	hydrophobic gate; other site
86416011221	periplasmic entrance; other site
86416011222	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
86416011223	Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174
86416011224	active site
86416011225	metal binding site [ion binding]; metal-binding site
86416011226	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416011227	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
86416011228	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416011229	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416011230	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416011231	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
86416011232	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
86416011233	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
86416011234	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
86416011235	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
86416011236	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
86416011237	TPP-binding site [chemical binding]; other site
86416011238	dimer interface [polypeptide binding]; other site
86416011239	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
86416011240	PYR/PP interface [polypeptide binding]; other site
86416011241	dimer interface [polypeptide binding]; other site
86416011242	TPP binding site [chemical binding]; other site
86416011243	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
86416011244	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
86416011245	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
86416011246	ABC-ATPase subunit  interface; other site
86416011247	dimer interface [polypeptide binding]; other site
86416011248	putative PBP binding regions; other site
86416011249	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
86416011250	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
86416011251	Walker A/P-loop; other site
86416011252	ATP binding site [chemical binding]; other site
86416011253	Q-loop/lid; other site
86416011254	ABC transporter signature motif; other site
86416011255	Walker B; other site
86416011256	D-loop; other site
86416011257	H-loop/switch region; other site
86416011258	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
86416011259	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
86416011260	putative ligand binding residues [chemical binding]; other site
86416011261	pyruvate carboxylase; Reviewed; Region: PRK12999
86416011262	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
86416011263	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
86416011264	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
86416011265	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
86416011266	active site
86416011267	catalytic residues [active]
86416011268	metal binding site [ion binding]; metal-binding site
86416011269	homodimer binding site [polypeptide binding]; other site
86416011270	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
86416011271	carboxyltransferase (CT) interaction site; other site
86416011272	biotinylation site [posttranslational modification]; other site
86416011273	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
86416011274	GIY-YIG motif/motif A; other site
86416011275	putative active site [active]
86416011276	putative metal binding site [ion binding]; other site
86416011277	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
86416011278	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
86416011279	ligand binding site [chemical binding]; other site
86416011280	flexible hinge region; other site
86416011281	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
86416011282	putative switch regulator; other site
86416011283	non-specific DNA interactions [nucleotide binding]; other site
86416011284	DNA binding site [nucleotide binding]
86416011285	sequence specific DNA binding site [nucleotide binding]; other site
86416011286	putative cAMP binding site [chemical binding]; other site
86416011287	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416011288	hydroxylamine reductase; Provisional; Region: PRK12310
86416011289	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416011290	ACS interaction site; other site
86416011291	CODH interaction site; other site
86416011292	metal cluster binding site [ion binding]; other site
86416011293	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416011294	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416011295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416011296	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
86416011297	active site
86416011298	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
86416011299	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
86416011300	Substrate binding site; other site
86416011301	Cupin domain; Region: Cupin_2; cl17218
86416011302	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
86416011303	active site
86416011304	DNA binding site [nucleotide binding]
86416011305	homoserine O-succinyltransferase; Provisional; Region: PRK05368
86416011306	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
86416011307	proposed active site lysine [active]
86416011308	conserved cys residue [active]
86416011309	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
86416011310	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
86416011311	Beta-Casp domain; Region: Beta-Casp; smart01027
86416011312	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
86416011313	RTX N-terminal domain; Region: RTX; pfam02382
86416011314	Response regulator receiver domain; Region: Response_reg; pfam00072
86416011315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416011316	active site
86416011317	phosphorylation site [posttranslational modification]
86416011318	intermolecular recognition site; other site
86416011319	dimerization interface [polypeptide binding]; other site
86416011320	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
86416011321	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
86416011322	active site
86416011323	dimer interface [polypeptide binding]; other site
86416011324	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
86416011325	dimer interface [polypeptide binding]; other site
86416011326	active site
86416011327	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
86416011328	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
86416011329	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416011330	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416011331	Walker A/P-loop; other site
86416011332	ATP binding site [chemical binding]; other site
86416011333	Q-loop/lid; other site
86416011334	ABC transporter signature motif; other site
86416011335	Walker B; other site
86416011336	D-loop; other site
86416011337	H-loop/switch region; other site
86416011338	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416011339	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416011340	FtsX-like permease family; Region: FtsX; pfam02687
86416011341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416011342	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416011343	dimerization interface [polypeptide binding]; other site
86416011344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416011345	dimer interface [polypeptide binding]; other site
86416011346	phosphorylation site [posttranslational modification]
86416011347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416011348	ATP binding site [chemical binding]; other site
86416011349	Mg2+ binding site [ion binding]; other site
86416011350	G-X-G motif; other site
86416011351	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416011352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416011353	active site
86416011354	phosphorylation site [posttranslational modification]
86416011355	intermolecular recognition site; other site
86416011356	dimerization interface [polypeptide binding]; other site
86416011357	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416011358	DNA binding site [nucleotide binding]
86416011359	Predicted membrane protein [Function unknown]; Region: COG2246
86416011360	GtrA-like protein; Region: GtrA; pfam04138
86416011361	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
86416011362	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416011363	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416011364	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416011365	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416011366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416011367	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416011368	dimerization interface [polypeptide binding]; other site
86416011369	Domain of unknown function (DUF370); Region: DUF370; cl00898
86416011370	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
86416011371	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
86416011372	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
86416011373	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
86416011374	putative FMN binding site [chemical binding]; other site
86416011375	Transcriptional regulators [Transcription]; Region: MarR; COG1846
86416011376	MarR family; Region: MarR_2; pfam12802
86416011377	MarR family; Region: MarR_2; cl17246
86416011378	Predicted membrane protein [Function unknown]; Region: COG2323
86416011379	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
86416011380	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
86416011381	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416011382	motif II; other site
86416011383	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
86416011384	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
86416011385	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
86416011386	active site
86416011387	substrate binding site [chemical binding]; other site
86416011388	metal binding site [ion binding]; metal-binding site
86416011389	H+ Antiporter protein; Region: 2A0121; TIGR00900
86416011390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416011391	putative substrate translocation pore; other site
86416011392	Transcriptional regulators [Transcription]; Region: PurR; COG1609
86416011393	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
86416011394	DNA binding site [nucleotide binding]
86416011395	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
86416011396	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416011397	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416011398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416011399	Walker A/P-loop; other site
86416011400	ATP binding site [chemical binding]; other site
86416011401	Q-loop/lid; other site
86416011402	ABC transporter signature motif; other site
86416011403	Walker B; other site
86416011404	D-loop; other site
86416011405	H-loop/switch region; other site
86416011406	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416011407	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416011408	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
86416011409	Walker A/P-loop; other site
86416011410	ATP binding site [chemical binding]; other site
86416011411	Q-loop/lid; other site
86416011412	ABC transporter signature motif; other site
86416011413	Walker B; other site
86416011414	D-loop; other site
86416011415	H-loop/switch region; other site
86416011416	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
86416011417	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
86416011418	Protein of unknown function (DUF4004); Region: DUF4004; pfam13171
86416011419	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
86416011420	nucleotide binding site [chemical binding]; other site
86416011421	Acetokinase family; Region: Acetate_kinase; cl17229
86416011422	phosphate butyryltransferase; Validated; Region: PRK05805
86416011423	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
86416011424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
86416011425	YbbR-like protein; Region: YbbR; pfam07949
86416011426	Uncharacterized conserved protein [Function unknown]; Region: COG1624
86416011427	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
86416011428	BON domain; Region: BON; pfam04972
86416011429	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
86416011430	BON domain; Region: BON; pfam04972
86416011431	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
86416011432	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
86416011433	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
86416011434	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
86416011435	catalytic residues [active]
86416011436	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
86416011437	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
86416011438	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
86416011439	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
86416011440	active site
86416011441	phosphorylation site [posttranslational modification]
86416011442	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
86416011443	active pocket/dimerization site; other site
86416011444	active site
86416011445	phosphorylation site [posttranslational modification]
86416011446	methionine sulfoxide reductase B; Provisional; Region: PRK00222
86416011447	SelR domain; Region: SelR; pfam01641
86416011448	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
86416011449	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
86416011450	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
86416011451	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
86416011452	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
86416011453	dimerization domain swap beta strand [polypeptide binding]; other site
86416011454	regulatory protein interface [polypeptide binding]; other site
86416011455	active site
86416011456	regulatory phosphorylation site [posttranslational modification]; other site
86416011457	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
86416011458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416011459	putative active site [active]
86416011460	heme pocket [chemical binding]; other site
86416011461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
86416011462	putative active site [active]
86416011463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416011464	Walker A motif; other site
86416011465	ATP binding site [chemical binding]; other site
86416011466	Walker B motif; other site
86416011467	arginine finger; other site
86416011468	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
86416011469	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
86416011470	active site
86416011471	P-loop; other site
86416011472	phosphorylation site [posttranslational modification]
86416011473	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
86416011474	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416011475	active site
86416011476	phosphorylation site [posttranslational modification]
86416011477	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416011478	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
86416011479	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416011480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
86416011481	binding surface
86416011482	TPR repeat; Region: TPR_11; pfam13414
86416011483	TPR motif; other site
86416011484	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
86416011485	fumarate hydratase; Provisional; Region: PRK06842
86416011486	fumarate hydratase; Provisional; Region: PRK06246
86416011487	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
86416011488	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
86416011489	active site
86416011490	metal binding site [ion binding]; metal-binding site
86416011491	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
86416011492	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
86416011493	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
86416011494	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
86416011495	23S rRNA interface [nucleotide binding]; other site
86416011496	L3 interface [polypeptide binding]; other site
86416011497	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
86416011498	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
86416011499	dimerization interface 3.5A [polypeptide binding]; other site
86416011500	active site
86416011501	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
86416011502	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
86416011503	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416011504	Walker A/P-loop; other site
86416011505	ATP binding site [chemical binding]; other site
86416011506	Q-loop/lid; other site
86416011507	ABC transporter signature motif; other site
86416011508	Walker B; other site
86416011509	D-loop; other site
86416011510	H-loop/switch region; other site
86416011511	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
86416011512	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
86416011513	Walker A/P-loop; other site
86416011514	ATP binding site [chemical binding]; other site
86416011515	Q-loop/lid; other site
86416011516	ABC transporter signature motif; other site
86416011517	Walker B; other site
86416011518	D-loop; other site
86416011519	H-loop/switch region; other site
86416011520	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
86416011521	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
86416011522	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
86416011523	alphaNTD homodimer interface [polypeptide binding]; other site
86416011524	alphaNTD - beta interaction site [polypeptide binding]; other site
86416011525	alphaNTD - beta' interaction site [polypeptide binding]; other site
86416011526	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
86416011527	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
86416011528	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
86416011529	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416011530	RNA binding surface [nucleotide binding]; other site
86416011531	30S ribosomal protein S11; Validated; Region: PRK05309
86416011532	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
86416011533	30S ribosomal protein S13; Region: bact_S13; TIGR03631
86416011534	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
86416011535	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
86416011536	rRNA binding site [nucleotide binding]; other site
86416011537	predicted 30S ribosome binding site; other site
86416011538	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
86416011539	RNA binding site [nucleotide binding]; other site
86416011540	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
86416011541	active site
86416011542	adenylate kinase; Reviewed; Region: adk; PRK00279
86416011543	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
86416011544	AMP-binding site [chemical binding]; other site
86416011545	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
86416011546	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
86416011547	SecY translocase; Region: SecY; pfam00344
86416011548	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
86416011549	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
86416011550	23S rRNA binding site [nucleotide binding]; other site
86416011551	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
86416011552	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
86416011553	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
86416011554	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
86416011555	5S rRNA interface [nucleotide binding]; other site
86416011556	L27 interface [polypeptide binding]; other site
86416011557	23S rRNA interface [nucleotide binding]; other site
86416011558	L5 interface [polypeptide binding]; other site
86416011559	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
86416011560	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
86416011561	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
86416011562	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
86416011563	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
86416011564	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
86416011565	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
86416011566	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
86416011567	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
86416011568	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
86416011569	RNA binding site [nucleotide binding]; other site
86416011570	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
86416011571	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
86416011572	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
86416011573	23S rRNA interface [nucleotide binding]; other site
86416011574	putative translocon interaction site; other site
86416011575	signal recognition particle (SRP54) interaction site; other site
86416011576	L23 interface [polypeptide binding]; other site
86416011577	trigger factor interaction site; other site
86416011578	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
86416011579	23S rRNA interface [nucleotide binding]; other site
86416011580	5S rRNA interface [nucleotide binding]; other site
86416011581	putative antibiotic binding site [chemical binding]; other site
86416011582	L25 interface [polypeptide binding]; other site
86416011583	L27 interface [polypeptide binding]; other site
86416011584	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
86416011585	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
86416011586	G-X-X-G motif; other site
86416011587	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
86416011588	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
86416011589	putative translocon binding site; other site
86416011590	protein-rRNA interface [nucleotide binding]; other site
86416011591	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
86416011592	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
86416011593	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
86416011594	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
86416011595	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
86416011596	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
86416011597	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
86416011598	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
86416011599	elongation factor Tu; Reviewed; Region: PRK00049
86416011600	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
86416011601	G1 box; other site
86416011602	GEF interaction site [polypeptide binding]; other site
86416011603	GTP/Mg2+ binding site [chemical binding]; other site
86416011604	Switch I region; other site
86416011605	G2 box; other site
86416011606	G3 box; other site
86416011607	Switch II region; other site
86416011608	G4 box; other site
86416011609	G5 box; other site
86416011610	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
86416011611	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
86416011612	Antibiotic Binding Site [chemical binding]; other site
86416011613	elongation factor G; Reviewed; Region: PRK00007
86416011614	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
86416011615	G1 box; other site
86416011616	putative GEF interaction site [polypeptide binding]; other site
86416011617	GTP/Mg2+ binding site [chemical binding]; other site
86416011618	Switch I region; other site
86416011619	G2 box; other site
86416011620	G3 box; other site
86416011621	Switch II region; other site
86416011622	G4 box; other site
86416011623	G5 box; other site
86416011624	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
86416011625	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
86416011626	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
86416011627	30S ribosomal protein S7; Validated; Region: PRK05302
86416011628	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
86416011629	S17 interaction site [polypeptide binding]; other site
86416011630	S8 interaction site; other site
86416011631	16S rRNA interaction site [nucleotide binding]; other site
86416011632	streptomycin interaction site [chemical binding]; other site
86416011633	23S rRNA interaction site [nucleotide binding]; other site
86416011634	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
86416011635	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
86416011636	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
86416011637	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
86416011638	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
86416011639	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
86416011640	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
86416011641	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
86416011642	G-loop; other site
86416011643	DNA binding site [nucleotide binding]
86416011644	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
86416011645	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
86416011646	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
86416011647	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
86416011648	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
86416011649	RPB1 interaction site [polypeptide binding]; other site
86416011650	RPB10 interaction site [polypeptide binding]; other site
86416011651	RPB11 interaction site [polypeptide binding]; other site
86416011652	RPB3 interaction site [polypeptide binding]; other site
86416011653	RPB12 interaction site [polypeptide binding]; other site
86416011654	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
86416011655	core dimer interface [polypeptide binding]; other site
86416011656	peripheral dimer interface [polypeptide binding]; other site
86416011657	L10 interface [polypeptide binding]; other site
86416011658	L11 interface [polypeptide binding]; other site
86416011659	putative EF-Tu interaction site [polypeptide binding]; other site
86416011660	putative EF-G interaction site [polypeptide binding]; other site
86416011661	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
86416011662	23S rRNA interface [nucleotide binding]; other site
86416011663	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
86416011664	Ribosomal protein L10 leader; Clopa_4523; IMG reference gene:2509571440
86416011665	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
86416011666	mRNA/rRNA interface [nucleotide binding]; other site
86416011667	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
86416011668	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
86416011669	23S rRNA interface [nucleotide binding]; other site
86416011670	L7/L12 interface [polypeptide binding]; other site
86416011671	putative thiostrepton binding site; other site
86416011672	L25 interface [polypeptide binding]; other site
86416011673	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
86416011674	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
86416011675	putative homodimer interface [polypeptide binding]; other site
86416011676	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
86416011677	heterodimer interface [polypeptide binding]; other site
86416011678	homodimer interface [polypeptide binding]; other site
86416011679	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
86416011680	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
86416011681	elongation factor Tu; Reviewed; Region: PRK00049
86416011682	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
86416011683	G1 box; other site
86416011684	GEF interaction site [polypeptide binding]; other site
86416011685	GTP/Mg2+ binding site [chemical binding]; other site
86416011686	Switch I region; other site
86416011687	G2 box; other site
86416011688	G3 box; other site
86416011689	Switch II region; other site
86416011690	G4 box; other site
86416011691	G5 box; other site
86416011692	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
86416011693	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
86416011694	Antibiotic Binding Site [chemical binding]; other site
86416011695	RNA polymerase factor sigma-70; Validated; Region: PRK08295
86416011696	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416011697	YacP-like NYN domain; Region: NYN_YacP; pfam05991
86416011698	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
86416011699	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
86416011700	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
86416011701	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
86416011702	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
86416011703	dimerization interface [polypeptide binding]; other site
86416011704	active site
86416011705	metal binding site [ion binding]; metal-binding site
86416011706	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
86416011707	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
86416011708	active site
86416011709	HIGH motif; other site
86416011710	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
86416011711	KMSKS motif; other site
86416011712	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
86416011713	tRNA binding surface [nucleotide binding]; other site
86416011714	anticodon binding site; other site
86416011715	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
86416011716	substrate binding site; other site
86416011717	dimer interface; other site
86416011718	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
86416011719	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
86416011720	putative active site [active]
86416011721	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
86416011722	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
86416011723	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
86416011724	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
86416011725	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
86416011726	DNA repair protein RadA; Provisional; Region: PRK11823
86416011727	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
86416011728	Walker A motif/ATP binding site; other site
86416011729	ATP binding site [chemical binding]; other site
86416011730	Walker B motif; other site
86416011731	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
86416011732	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
86416011733	Clp amino terminal domain; Region: Clp_N; pfam02861
86416011734	Clp amino terminal domain; Region: Clp_N; pfam02861
86416011735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416011736	Walker A motif; other site
86416011737	ATP binding site [chemical binding]; other site
86416011738	Walker B motif; other site
86416011739	arginine finger; other site
86416011740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416011741	Walker A motif; other site
86416011742	ATP binding site [chemical binding]; other site
86416011743	Walker B motif; other site
86416011744	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
86416011745	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
86416011746	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
86416011747	ADP binding site [chemical binding]; other site
86416011748	phosphagen binding site; other site
86416011749	substrate specificity loop; other site
86416011750	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
86416011751	UvrB/uvrC motif; Region: UVR; pfam02151
86416011752	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
86416011753	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710
86416011754	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
86416011755	NAD(P) binding pocket [chemical binding]; other site
86416011756	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
86416011757	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
86416011758	glycyl-tRNA synthetase; Provisional; Region: PRK04173
86416011759	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
86416011760	motif 1; other site
86416011761	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
86416011762	active site
86416011763	motif 2; other site
86416011764	motif 3; other site
86416011765	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
86416011766	anticodon binding site; other site
86416011767	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
86416011768	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
86416011769	dimer interface [polypeptide binding]; other site
86416011770	putative anticodon binding site; other site
86416011771	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
86416011772	motif 1; other site
86416011773	active site
86416011774	motif 2; other site
86416011775	motif 3; other site
86416011776	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
86416011777	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
86416011778	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
86416011779	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
86416011780	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
86416011781	FMN binding site [chemical binding]; other site
86416011782	active site
86416011783	catalytic residues [active]
86416011784	substrate binding site [chemical binding]; other site
86416011785	pantothenate kinase; Reviewed; Region: PRK13318
86416011786	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
86416011787	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
86416011788	Potassium binding sites [ion binding]; other site
86416011789	Cesium cation binding sites [ion binding]; other site
86416011790	FtsH Extracellular; Region: FtsH_ext; pfam06480
86416011791	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
86416011792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416011793	Walker A motif; other site
86416011794	ATP binding site [chemical binding]; other site
86416011795	Walker B motif; other site
86416011796	arginine finger; other site
86416011797	Peptidase family M41; Region: Peptidase_M41; pfam01434
86416011798	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416011799	active site
86416011800	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
86416011801	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
86416011802	Ligand Binding Site [chemical binding]; other site
86416011803	TilS substrate C-terminal domain; Region: TilS_C; smart00977
86416011804	stage II sporulation protein E; Region: spore_II_E; TIGR02865
86416011805	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
86416011806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
86416011807	hypothetical protein; Provisional; Region: PRK05807
86416011808	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
86416011809	RNA binding site [nucleotide binding]; other site
86416011810	Septum formation initiator; Region: DivIC; pfam04977
86416011811	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
86416011812	YabP family; Region: YabP; cl06766
86416011813	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
86416011814	RNA binding surface [nucleotide binding]; other site
86416011815	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
86416011816	IHF dimer interface [polypeptide binding]; other site
86416011817	IHF - DNA interface [nucleotide binding]; other site
86416011818	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
86416011819	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
86416011820	putative SAM binding site [chemical binding]; other site
86416011821	putative homodimer interface [polypeptide binding]; other site
86416011822	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
86416011823	homodimer interface [polypeptide binding]; other site
86416011824	metal binding site [ion binding]; metal-binding site
86416011825	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
86416011826	homodimer interface [polypeptide binding]; other site
86416011827	active site
86416011828	putative chemical substrate binding site [chemical binding]; other site
86416011829	metal binding site [ion binding]; metal-binding site
86416011830	stage V sporulation protein B; Region: spore_V_B; TIGR02900
86416011831	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
86416011832	stage V sporulation protein T; Region: spore_V_T; TIGR02851
86416011833	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
86416011834	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
86416011835	SurA N-terminal domain; Region: SurA_N_3; cl07813
86416011836	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
86416011837	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
86416011838	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
86416011839	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416011840	ATP binding site [chemical binding]; other site
86416011841	putative Mg++ binding site [ion binding]; other site
86416011842	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416011843	nucleotide binding region [chemical binding]; other site
86416011844	ATP-binding site [chemical binding]; other site
86416011845	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
86416011846	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
86416011847	putative active site [active]
86416011848	catalytic residue [active]
86416011849	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
86416011850	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
86416011851	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
86416011852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416011853	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416011854	dimerization interface [polypeptide binding]; other site
86416011855	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416011856	dimer interface [polypeptide binding]; other site
86416011857	phosphorylation site [posttranslational modification]
86416011858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416011859	ATP binding site [chemical binding]; other site
86416011860	Mg2+ binding site [ion binding]; other site
86416011861	G-X-G motif; other site
86416011862	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416011863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416011864	active site
86416011865	phosphorylation site [posttranslational modification]
86416011866	intermolecular recognition site; other site
86416011867	dimerization interface [polypeptide binding]; other site
86416011868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416011869	DNA binding site [nucleotide binding]
86416011870	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
86416011871	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
86416011872	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416011873	active site
86416011874	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
86416011875	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
86416011876	Substrate binding site; other site
86416011877	Mg++ binding site; other site
86416011878	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
86416011879	active site
86416011880	substrate binding site [chemical binding]; other site
86416011881	CoA binding site [chemical binding]; other site
86416011882	regulatory protein SpoVG; Reviewed; Region: PRK13259
86416011883	pur operon repressor; Provisional; Region: PRK09213
86416011884	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
86416011885	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
86416011886	active site
86416011887	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
86416011888	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
86416011889	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
86416011890	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
86416011891	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416011892	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416011893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416011894	Walker A/P-loop; other site
86416011895	ATP binding site [chemical binding]; other site
86416011896	Q-loop/lid; other site
86416011897	ABC transporter signature motif; other site
86416011898	Walker B; other site
86416011899	D-loop; other site
86416011900	H-loop/switch region; other site
86416011901	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416011902	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416011903	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
86416011904	Walker A/P-loop; other site
86416011905	ATP binding site [chemical binding]; other site
86416011906	Q-loop/lid; other site
86416011907	ABC transporter signature motif; other site
86416011908	Walker B; other site
86416011909	D-loop; other site
86416011910	H-loop/switch region; other site
86416011911	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
86416011912	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
86416011913	Walker A/P-loop; other site
86416011914	ATP binding site [chemical binding]; other site
86416011915	Q-loop/lid; other site
86416011916	ABC transporter signature motif; other site
86416011917	Walker B; other site
86416011918	D-loop; other site
86416011919	H-loop/switch region; other site
86416011920	Predicted transcriptional regulators [Transcription]; Region: COG1725
86416011921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416011922	DNA-binding site [nucleotide binding]; DNA binding site
86416011923	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
86416011924	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
86416011925	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
86416011926	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
86416011927	active site
86416011928	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
86416011929	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
86416011930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
86416011931	motif II; other site
86416011932	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
86416011933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416011934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416011935	ABC transporter; Region: ABC_tran_2; pfam12848
86416011936	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
86416011937	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
86416011938	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
86416011939	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
86416011940	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
86416011941	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
86416011942	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
86416011943	Walker A/P-loop; other site
86416011944	ATP binding site [chemical binding]; other site
86416011945	Q-loop/lid; other site
86416011946	ABC transporter signature motif; other site
86416011947	Walker B; other site
86416011948	D-loop; other site
86416011949	H-loop/switch region; other site
86416011950	TOBE domain; Region: TOBE_2; pfam08402
86416011951	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
86416011952	Uncharacterized membrane protein [Function unknown]; Region: COG3949
86416011953	Radical SAM superfamily; Region: Radical_SAM; pfam04055
86416011954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416011955	FeS/SAM binding site; other site
86416011956	Heme NO binding; Region: HNOB; pfam07700
86416011957	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
86416011958	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
86416011959	dimer interface [polypeptide binding]; other site
86416011960	putative CheW interface [polypeptide binding]; other site
86416011961	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416011962	non-specific DNA binding site [nucleotide binding]; other site
86416011963	salt bridge; other site
86416011964	sequence-specific DNA binding site [nucleotide binding]; other site
86416011965	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
86416011966	Catalytic site [active]
86416011967	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
86416011968	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
86416011969	active site
86416011970	glutamate racemase; Provisional; Region: PRK00865
86416011971	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
86416011972	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
86416011973	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
86416011974	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
86416011975	pyrroline-5-carboxylate reductase; Region: PLN02688
86416011976	gamma-glutamyl kinase; Provisional; Region: PRK05429
86416011977	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
86416011978	nucleotide binding site [chemical binding]; other site
86416011979	homotetrameric interface [polypeptide binding]; other site
86416011980	putative phosphate binding site [ion binding]; other site
86416011981	putative allosteric binding site; other site
86416011982	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
86416011983	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
86416011984	putative catalytic cysteine [active]
86416011985	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
86416011986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416011987	DNA-binding site [nucleotide binding]; DNA binding site
86416011988	UTRA domain; Region: UTRA; cl17743
86416011989	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
86416011990	putative hydrolase; Provisional; Region: PRK02113
86416011991	PHP domain; Region: PHP; pfam02811
86416011992	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
86416011993	active site
86416011994	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
86416011995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416011996	dimer interface [polypeptide binding]; other site
86416011997	conserved gate region; other site
86416011998	putative PBP binding loops; other site
86416011999	ABC-ATPase subunit interface; other site
86416012000	hypothetical protein; Provisional; Region: PRK11622
86416012001	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
86416012002	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
86416012003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012004	Walker A/P-loop; other site
86416012005	ATP binding site [chemical binding]; other site
86416012006	Q-loop/lid; other site
86416012007	ABC transporter signature motif; other site
86416012008	Walker B; other site
86416012009	D-loop; other site
86416012010	H-loop/switch region; other site
86416012011	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
86416012012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416012013	dimer interface [polypeptide binding]; other site
86416012014	conserved gate region; other site
86416012015	putative PBP binding loops; other site
86416012016	ABC-ATPase subunit interface; other site
86416012017	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
86416012018	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
86416012019	active site
86416012020	catalytic site [active]
86416012021	metal binding site [ion binding]; metal-binding site
86416012022	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
86416012023	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
86416012024	putative dimer interface [polypeptide binding]; other site
86416012025	putative anticodon binding site; other site
86416012026	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
86416012027	homodimer interface [polypeptide binding]; other site
86416012028	motif 1; other site
86416012029	motif 2; other site
86416012030	active site
86416012031	motif 3; other site
86416012032	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
86416012033	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
86416012034	active site
86416012035	dimer interface [polypeptide binding]; other site
86416012036	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
86416012037	Ligand Binding Site [chemical binding]; other site
86416012038	Molecular Tunnel; other site
86416012039	Rubredoxin [Energy production and conversion]; Region: COG1773
86416012040	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
86416012041	iron binding site [ion binding]; other site
86416012042	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
86416012043	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
86416012044	dimer interface [polypeptide binding]; other site
86416012045	decamer (pentamer of dimers) interface [polypeptide binding]; other site
86416012046	catalytic triad [active]
86416012047	peroxidatic and resolving cysteines [active]
86416012048	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
86416012049	catalytic residues [active]
86416012050	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
86416012051	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
86416012052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
86416012053	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
86416012054	CotJB protein; Region: CotJB; pfam12652
86416012055	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
86416012056	dimanganese center [ion binding]; other site
86416012057	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
86416012058	Cupin domain; Region: Cupin_2; pfam07883
86416012059	Helix-turn-helix domain; Region: HTH_18; pfam12833
86416012060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416012061	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416012062	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416012063	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
86416012064	Walker A/P-loop; other site
86416012065	ATP binding site [chemical binding]; other site
86416012066	Q-loop/lid; other site
86416012067	ABC transporter signature motif; other site
86416012068	Walker B; other site
86416012069	D-loop; other site
86416012070	H-loop/switch region; other site
86416012071	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416012072	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416012073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012074	Walker A/P-loop; other site
86416012075	ATP binding site [chemical binding]; other site
86416012076	Q-loop/lid; other site
86416012077	ABC transporter signature motif; other site
86416012078	Walker B; other site
86416012079	D-loop; other site
86416012080	H-loop/switch region; other site
86416012081	Transcriptional regulators [Transcription]; Region: MarR; COG1846
86416012082	MarR family; Region: MarR; pfam01047
86416012083	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
86416012084	ATP binding site [chemical binding]; other site
86416012085	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
86416012086	putative Mg++ binding site [ion binding]; other site
86416012087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416012088	nucleotide binding region [chemical binding]; other site
86416012089	ATP-binding site [chemical binding]; other site
86416012090	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
86416012091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416012092	dimer interface [polypeptide binding]; other site
86416012093	conserved gate region; other site
86416012094	putative PBP binding loops; other site
86416012095	ABC-ATPase subunit interface; other site
86416012096	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
86416012097	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
86416012098	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
86416012099	Walker A/P-loop; other site
86416012100	ATP binding site [chemical binding]; other site
86416012101	Q-loop/lid; other site
86416012102	ABC transporter signature motif; other site
86416012103	Walker B; other site
86416012104	D-loop; other site
86416012105	H-loop/switch region; other site
86416012106	FOG: CBS domain [General function prediction only]; Region: COG0517
86416012107	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
86416012108	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
86416012109	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416012110	DNA-binding site [nucleotide binding]; DNA binding site
86416012111	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
86416012112	TrkA-C domain; Region: TrkA_C; pfam02080
86416012113	Dehydroquinase class II; Region: DHquinase_II; pfam01220
86416012114	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
86416012115	trimer interface [polypeptide binding]; other site
86416012116	active site
86416012117	dimer interface [polypeptide binding]; other site
86416012118	shikimate kinase; Reviewed; Region: aroK; PRK00131
86416012119	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
86416012120	ADP binding site [chemical binding]; other site
86416012121	magnesium binding site [ion binding]; other site
86416012122	putative shikimate binding site; other site
86416012123	hypothetical protein; Provisional; Region: PRK07248
86416012124	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
86416012125	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
86416012126	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
86416012127	shikimate binding site; other site
86416012128	NAD(P) binding site [chemical binding]; other site
86416012129	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
86416012130	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
86416012131	Tetramer interface [polypeptide binding]; other site
86416012132	active site
86416012133	FMN-binding site [chemical binding]; other site
86416012134	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
86416012135	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
86416012136	hinge; other site
86416012137	active site
86416012138	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
86416012139	active site
86416012140	dimer interface [polypeptide binding]; other site
86416012141	metal binding site [ion binding]; metal-binding site
86416012142	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
86416012143	prephenate dehydrogenase; Validated; Region: PRK08507
86416012144	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
86416012145	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
86416012146	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
86416012147	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
86416012148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416012149	Coenzyme A binding pocket [chemical binding]; other site
86416012150	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
86416012151	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
86416012152	dimer interface [polypeptide binding]; other site
86416012153	active site
86416012154	metal binding site [ion binding]; metal-binding site
86416012155	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
86416012156	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
86416012157	trimerization site [polypeptide binding]; other site
86416012158	active site
86416012159	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
86416012160	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
86416012161	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
86416012162	catalytic residue [active]
86416012163	FeS assembly protein SufD; Region: sufD; TIGR01981
86416012164	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
86416012165	FeS assembly protein SufB; Region: sufB; TIGR01980
86416012166	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
86416012167	FeS assembly ATPase SufC; Region: sufC; TIGR01978
86416012168	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
86416012169	Walker A/P-loop; other site
86416012170	ATP binding site [chemical binding]; other site
86416012171	Q-loop/lid; other site
86416012172	ABC transporter signature motif; other site
86416012173	Walker B; other site
86416012174	D-loop; other site
86416012175	H-loop/switch region; other site
86416012176	glyoxylate reductase; Reviewed; Region: PRK13243
86416012177	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
86416012178	dimerization interface [polypeptide binding]; other site
86416012179	ligand binding site [chemical binding]; other site
86416012180	NADP binding site [chemical binding]; other site
86416012181	catalytic site [active]
86416012182	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
86416012183	active site
86416012184	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
86416012185	active site
86416012186	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
86416012187	active site
86416012188	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
86416012189	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
86416012190	substrate binding [chemical binding]; other site
86416012191	active site
86416012192	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
86416012193	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
86416012194	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
86416012195	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
86416012196	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
86416012197	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
86416012198	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
86416012199	Protein of unknown function (DUF441); Region: DUF441; pfam04284
86416012200	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416012201	FtsX-like permease family; Region: FtsX; pfam02687
86416012202	FtsX-like permease family; Region: FtsX; pfam02687
86416012203	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416012204	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416012205	Walker A/P-loop; other site
86416012206	ATP binding site [chemical binding]; other site
86416012207	Q-loop/lid; other site
86416012208	ABC transporter signature motif; other site
86416012209	Walker B; other site
86416012210	D-loop; other site
86416012211	H-loop/switch region; other site
86416012212	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416012213	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416012214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416012215	Major Facilitator Superfamily; Region: MFS_1; pfam07690
86416012216	putative substrate translocation pore; other site
86416012217	FtsX-like permease family; Region: FtsX; pfam02687
86416012218	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416012219	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416012220	Walker A/P-loop; other site
86416012221	ATP binding site [chemical binding]; other site
86416012222	Q-loop/lid; other site
86416012223	ABC transporter signature motif; other site
86416012224	Walker B; other site
86416012225	D-loop; other site
86416012226	H-loop/switch region; other site
86416012227	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416012228	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416012229	dimer interface [polypeptide binding]; other site
86416012230	phosphorylation site [posttranslational modification]
86416012231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416012232	ATP binding site [chemical binding]; other site
86416012233	Mg2+ binding site [ion binding]; other site
86416012234	G-X-G motif; other site
86416012235	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416012236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416012237	active site
86416012238	phosphorylation site [posttranslational modification]
86416012239	intermolecular recognition site; other site
86416012240	dimerization interface [polypeptide binding]; other site
86416012241	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416012242	DNA binding site [nucleotide binding]
86416012243	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012244	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416012245	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416012246	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416012247	TOBE domain; Region: TOBE; cl01440
86416012248	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
86416012249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416012250	putative substrate translocation pore; other site
86416012251	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416012252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416012253	active site
86416012254	phosphorylation site [posttranslational modification]
86416012255	intermolecular recognition site; other site
86416012256	dimerization interface [polypeptide binding]; other site
86416012257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416012258	DNA binding site [nucleotide binding]
86416012259	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416012260	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
86416012261	dimerization interface [polypeptide binding]; other site
86416012262	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416012263	dimer interface [polypeptide binding]; other site
86416012264	phosphorylation site [posttranslational modification]
86416012265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416012266	ATP binding site [chemical binding]; other site
86416012267	Mg2+ binding site [ion binding]; other site
86416012268	G-X-G motif; other site
86416012269	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012270	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
86416012271	Walker A/P-loop; other site
86416012272	ATP binding site [chemical binding]; other site
86416012273	Q-loop/lid; other site
86416012274	ABC transporter signature motif; other site
86416012275	Walker B; other site
86416012276	D-loop; other site
86416012277	H-loop/switch region; other site
86416012278	ABC-2 type transporter; Region: ABC2_membrane; cl17235
86416012279	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
86416012280	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
86416012281	Predicted transcriptional regulators [Transcription]; Region: COG1695
86416012282	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
86416012283	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
86416012284	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416012285	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416012286	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416012287	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
86416012288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416012289	putative substrate translocation pore; other site
86416012290	D-mannonate oxidoreductase; Provisional; Region: PRK08277
86416012291	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
86416012292	putative NAD(P) binding site [chemical binding]; other site
86416012293	active site
86416012294	mannonate dehydratase; Provisional; Region: PRK03906
86416012295	mannonate dehydratase; Region: uxuA; TIGR00695
86416012296	Glucuronate isomerase; Region: UxaC; pfam02614
86416012297	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
86416012298	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
86416012299	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
86416012300	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
86416012301	Transposase; Region: DEDD_Tnp_IS110; pfam01548
86416012302	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
86416012303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
86416012304	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
86416012305	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
86416012306	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
86416012307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
86416012308	Domain of unknown function DUF77; Region: DUF77; pfam01910
86416012309	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
86416012310	dimer interface [polypeptide binding]; other site
86416012311	catalytic triad [active]
86416012312	peroxidatic and resolving cysteines [active]
86416012313	Uncharacterized conserved protein [Function unknown]; Region: COG1359
86416012314	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
86416012315	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
86416012316	ligand binding site [chemical binding]; other site
86416012317	NAD binding site [chemical binding]; other site
86416012318	dimerization interface [polypeptide binding]; other site
86416012319	catalytic site [active]
86416012320	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
86416012321	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
86416012322	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
86416012323	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012324	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416012325	MarR family; Region: MarR_2; pfam12802
86416012326	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
86416012327	dimerization interface [polypeptide binding]; other site
86416012328	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416012329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
86416012330	dimer interface [polypeptide binding]; other site
86416012331	phosphorylation site [posttranslational modification]
86416012332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416012333	ATP binding site [chemical binding]; other site
86416012334	Mg2+ binding site [ion binding]; other site
86416012335	G-X-G motif; other site
86416012336	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
86416012337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416012338	active site
86416012339	phosphorylation site [posttranslational modification]
86416012340	intermolecular recognition site; other site
86416012341	dimerization interface [polypeptide binding]; other site
86416012342	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
86416012343	DNA binding site [nucleotide binding]
86416012344	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
86416012345	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012346	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416012347	MarR family; Region: MarR_2; pfam12802
86416012348	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
86416012349	GIY-YIG motif/motif A; other site
86416012350	active site
86416012351	catalytic site [active]
86416012352	putative DNA binding site [nucleotide binding]; other site
86416012353	metal binding site [ion binding]; metal-binding site
86416012354	UvrB/uvrC motif; Region: UVR; pfam02151
86416012355	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416012356	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
86416012357	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416012358	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416012359	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
86416012360	active site
86416012361	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
86416012362	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
86416012363	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
86416012364	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
86416012365	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
86416012366	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
86416012367	dimer interface [polypeptide binding]; other site
86416012368	active site
86416012369	glycine loop; other site
86416012370	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
86416012371	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
86416012372	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
86416012373	Predicted transcriptional regulator [Transcription]; Region: COG2378
86416012374	HTH domain; Region: HTH_11; pfam08279
86416012375	WYL domain; Region: WYL; pfam13280
86416012376	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
86416012377	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416012378	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416012379	Coenzyme A binding pocket [chemical binding]; other site
86416012380	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
86416012381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
86416012382	DNA binding residues [nucleotide binding]
86416012383	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
86416012384	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
86416012385	DEAD-like helicases superfamily; Region: DEXDc; smart00487
86416012386	ATP binding site [chemical binding]; other site
86416012387	Mg++ binding site [ion binding]; other site
86416012388	motif III; other site
86416012389	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
86416012390	nucleotide binding region [chemical binding]; other site
86416012391	ATP-binding site [chemical binding]; other site
86416012392	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
86416012393	DNA-binding site [nucleotide binding]; DNA binding site
86416012394	RNA-binding motif; other site
86416012395	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
86416012396	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
86416012397	active site
86416012398	catalytic tetrad [active]
86416012399	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
86416012400	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
86416012401	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416012402	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
86416012403	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
86416012404	active site
86416012405	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416012406	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
86416012407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416012408	Coenzyme A binding pocket [chemical binding]; other site
86416012409	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416012410	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
86416012411	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416012412	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
86416012413	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416012414	MarR family; Region: MarR_2; pfam12802
86416012415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416012416	Coenzyme A binding pocket [chemical binding]; other site
86416012417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
86416012418	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
86416012419	Coenzyme A binding pocket [chemical binding]; other site
86416012420	Winged helix-turn helix; Region: HTH_29; pfam13551
86416012421	Homeodomain-like domain; Region: HTH_32; pfam13565
86416012422	Winged helix-turn helix; Region: HTH_33; pfam13592
86416012423	DDE superfamily endonuclease; Region: DDE_3; pfam13358
86416012424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
86416012425	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
86416012426	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
86416012427	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
86416012428	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
86416012429	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
86416012430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012431	Walker A/P-loop; other site
86416012432	ATP binding site [chemical binding]; other site
86416012433	Q-loop/lid; other site
86416012434	ABC transporter signature motif; other site
86416012435	Walker B; other site
86416012436	D-loop; other site
86416012437	H-loop/switch region; other site
86416012438	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
86416012439	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
86416012440	DNA binding residues [nucleotide binding]
86416012441	Methyltransferase domain; Region: Methyltransf_26; pfam13659
86416012442	H+ Antiporter protein; Region: 2A0121; TIGR00900
86416012443	DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176
86416012444	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
86416012445	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
86416012446	generic binding surface II; other site
86416012447	generic binding surface I; other site
86416012448	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
86416012449	active site
86416012450	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
86416012451	active site
86416012452	catalytic site [active]
86416012453	substrate binding site [chemical binding]; other site
86416012454	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
86416012455	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
86416012456	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
86416012457	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416012458	putative active site [active]
86416012459	putative NTP binding site [chemical binding]; other site
86416012460	putative nucleic acid binding site [nucleotide binding]; other site
86416012461	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416012462	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
86416012463	active site
86416012464	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
86416012466	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
86416012467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012468	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416012469	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416012470	putative active site [active]
86416012471	putative NTP binding site [chemical binding]; other site
86416012472	putative nucleic acid binding site [nucleotide binding]; other site
86416012473	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416012474	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
86416012475	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
86416012476	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
86416012477	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
86416012478	Transposase; Region: HTH_Tnp_1; pfam01527
86416012479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
86416012480	putative transposase OrfB; Reviewed; Region: PHA02517
86416012481	HTH-like domain; Region: HTH_21; pfam13276
86416012482	Integrase core domain; Region: rve; pfam00665
86416012483	Integrase core domain; Region: rve_3; pfam13683
86416012484	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
86416012485	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
86416012486	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
86416012487	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
86416012488	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
86416012489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416012490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416012491	homodimer interface [polypeptide binding]; other site
86416012492	catalytic residue [active]
86416012493	hypothetical protein; Provisional; Region: PRK05590
86416012494	SEC-C motif; Region: SEC-C; pfam02810
86416012495	YyzF-like protein; Region: YyzF; cl15733
86416012496	Sporulation and spore germination; Region: Germane; pfam10646
86416012497	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
86416012498	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
86416012499	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
86416012500	hinge; other site
86416012501	active site
86416012502	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
86416012503	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
86416012504	homodimer interface [polypeptide binding]; other site
86416012505	substrate-cofactor binding pocket; other site
86416012506	catalytic residue [active]
86416012507	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
86416012508	dUTPase; Region: dUTPase_2; pfam08761
86416012509	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
86416012510	active site
86416012511	homodimer interface [polypeptide binding]; other site
86416012512	metal binding site [ion binding]; metal-binding site
86416012513	Protein of unknown function, DUF606; Region: DUF606; pfam04657
86416012514	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
86416012515	active site
86416012516	catalytic residues [active]
86416012517	ribonuclease Z; Reviewed; Region: PRK00055
86416012518	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
86416012519	Ferritin-like domain; Region: Ferritin; pfam00210
86416012520	ferroxidase diiron center [ion binding]; other site
86416012521	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
86416012522	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
86416012523	active site
86416012524	metal binding site [ion binding]; metal-binding site
86416012525	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
86416012526	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
86416012527	HlyD family secretion protein; Region: HlyD_3; pfam13437
86416012528	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416012529	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416012530	Walker A/P-loop; other site
86416012531	ATP binding site [chemical binding]; other site
86416012532	Q-loop/lid; other site
86416012533	ABC transporter signature motif; other site
86416012534	Walker B; other site
86416012535	D-loop; other site
86416012536	H-loop/switch region; other site
86416012537	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416012538	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416012539	FtsX-like permease family; Region: FtsX; pfam02687
86416012540	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416012541	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
86416012542	FtsX-like permease family; Region: FtsX; pfam02687
86416012543	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
86416012544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012545	Walker A/P-loop; other site
86416012546	ATP binding site [chemical binding]; other site
86416012547	Q-loop/lid; other site
86416012548	ABC transporter signature motif; other site
86416012549	Walker B; other site
86416012550	D-loop; other site
86416012551	H-loop/switch region; other site
86416012552	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
86416012553	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
86416012554	metal binding site [ion binding]; metal-binding site
86416012555	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
86416012556	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416012557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012558	Walker A/P-loop; other site
86416012559	ATP binding site [chemical binding]; other site
86416012560	Q-loop/lid; other site
86416012561	ABC transporter signature motif; other site
86416012562	Walker B; other site
86416012563	D-loop; other site
86416012564	H-loop/switch region; other site
86416012565	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378
86416012566	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
86416012567	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
86416012568	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
86416012569	dimerization interface [polypeptide binding]; other site
86416012570	active site
86416012571	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
86416012572	DNA topoisomerase III; Provisional; Region: PRK07726
86416012573	active site
86416012574	putative interdomain interaction site [polypeptide binding]; other site
86416012575	putative metal-binding site [ion binding]; other site
86416012576	putative nucleotide binding site [chemical binding]; other site
86416012577	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
86416012578	domain I; other site
86416012579	DNA binding groove [nucleotide binding]
86416012580	phosphate binding site [ion binding]; other site
86416012581	domain II; other site
86416012582	domain III; other site
86416012583	nucleotide binding site [chemical binding]; other site
86416012584	catalytic site [active]
86416012585	domain IV; other site
86416012586	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
86416012587	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
86416012588	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
86416012589	LDH/MDH dimer interface [polypeptide binding]; other site
86416012590	NAD(P) binding site [chemical binding]; other site
86416012591	substrate binding site [chemical binding]; other site
86416012592	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
86416012593	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
86416012594	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
86416012595	biotin carboxylase; Validated; Region: PRK05586
86416012596	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
86416012597	ATP-grasp domain; Region: ATP-grasp_4; cl17255
86416012598	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
86416012599	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
86416012600	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
86416012601	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
86416012602	carboxyltransferase (CT) interaction site; other site
86416012603	biotinylation site [posttranslational modification]; other site
86416012604	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
86416012605	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
86416012606	dimer interface [polypeptide binding]; other site
86416012607	active site
86416012608	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
86416012609	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
86416012610	NAD(P) binding site [chemical binding]; other site
86416012611	homotetramer interface [polypeptide binding]; other site
86416012612	homodimer interface [polypeptide binding]; other site
86416012613	active site
86416012614	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
86416012615	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
86416012616	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
86416012617	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
86416012618	FMN binding site [chemical binding]; other site
86416012619	substrate binding site [chemical binding]; other site
86416012620	putative catalytic residue [active]
86416012621	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
86416012622	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
86416012623	dimer interface [polypeptide binding]; other site
86416012624	active site
86416012625	CoA binding pocket [chemical binding]; other site
86416012626	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416012627	MarR family; Region: MarR_2; pfam12802
86416012628	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
86416012629	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
86416012630	FMN binding site [chemical binding]; other site
86416012631	substrate binding site [chemical binding]; other site
86416012632	putative catalytic residue [active]
86416012633	HlyD family secretion protein; Region: HlyD_3; pfam13437
86416012634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
86416012635	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
86416012636	Walker A/P-loop; other site
86416012637	ATP binding site [chemical binding]; other site
86416012638	Q-loop/lid; other site
86416012639	ABC transporter signature motif; other site
86416012640	Walker B; other site
86416012641	D-loop; other site
86416012642	H-loop/switch region; other site
86416012643	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
86416012644	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
86416012645	FtsX-like permease family; Region: FtsX; pfam02687
86416012646	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
86416012647	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
86416012648	FAD binding site [chemical binding]; other site
86416012649	competence damage-inducible protein A; Provisional; Region: PRK00549
86416012650	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
86416012651	putative MPT binding site; other site
86416012652	Competence-damaged protein; Region: CinA; pfam02464
86416012653	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
86416012654	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
86416012655	Peptidase family M23; Region: Peptidase_M23; pfam01551
86416012656	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
86416012657	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
86416012658	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
86416012659	DNA replication protein DnaC; Validated; Region: PRK06835
86416012660	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416012661	Walker A motif; other site
86416012662	ATP binding site [chemical binding]; other site
86416012663	CoA binding domain; Region: CoA_binding_2; pfam13380
86416012664	flavoprotein, HI0933 family; Region: TIGR00275
86416012665	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
86416012666	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
86416012667	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
86416012668	active site
86416012669	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
86416012670	active site 2 [active]
86416012671	active site 1 [active]
86416012672	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
86416012673	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
86416012674	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
86416012675	GDP-binding site [chemical binding]; other site
86416012676	ACT binding site; other site
86416012677	IMP binding site; other site
86416012678	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
86416012679	lycopene cyclase; Region: lycopene_cycl; TIGR01789
86416012680	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
86416012681	Rubredoxin; Region: Rubredoxin; pfam00301
86416012682	iron binding site [ion binding]; other site
86416012683	Rubrerythrin [Energy production and conversion]; Region: COG1592
86416012684	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
86416012685	diiron binding motif [ion binding]; other site
86416012686	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
86416012687	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
86416012688	active site
86416012689	dimer interface [polypeptide binding]; other site
86416012690	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
86416012691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
86416012692	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
86416012693	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
86416012694	metal ion-dependent adhesion site (MIDAS); other site
86416012695	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
86416012696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416012697	Walker A motif; other site
86416012698	ATP binding site [chemical binding]; other site
86416012699	Walker B motif; other site
86416012700	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
86416012701	active site
86416012702	phosphorylation site [posttranslational modification]
86416012703	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
86416012704	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
86416012705	active site
86416012706	P-loop; other site
86416012707	phosphorylation site [posttranslational modification]
86416012708	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
86416012709	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
86416012710	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
86416012711	putative substrate binding site [chemical binding]; other site
86416012712	putative ATP binding site [chemical binding]; other site
86416012713	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
86416012714	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416012715	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416012716	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
86416012717	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
86416012718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
86416012719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
86416012720	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
86416012721	dimerization interface [polypeptide binding]; other site
86416012722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
86416012723	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
86416012724	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416012725	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012726	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
86416012727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
86416012728	putative substrate translocation pore; other site
86416012729	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
86416012730	dinuclear metal binding motif [ion binding]; other site
86416012731	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
86416012732	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
86416012733	substrate binding pocket [chemical binding]; other site
86416012734	membrane-bound complex binding site; other site
86416012735	hinge residues; other site
86416012736	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
86416012737	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
86416012738	Walker A/P-loop; other site
86416012739	ATP binding site [chemical binding]; other site
86416012740	Q-loop/lid; other site
86416012741	ABC transporter signature motif; other site
86416012742	Walker B; other site
86416012743	D-loop; other site
86416012744	H-loop/switch region; other site
86416012745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416012746	dimer interface [polypeptide binding]; other site
86416012747	conserved gate region; other site
86416012748	putative PBP binding loops; other site
86416012749	ABC-ATPase subunit interface; other site
86416012750	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
86416012751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
86416012752	dimer interface [polypeptide binding]; other site
86416012753	conserved gate region; other site
86416012754	ABC-ATPase subunit interface; other site
86416012755	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
86416012756	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
86416012757	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
86416012758	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
86416012759	active site
86416012760	metal binding site [ion binding]; metal-binding site
86416012761	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012762	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416012763	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
86416012764	MarR family; Region: MarR_2; cl17246
86416012765	LytTr DNA-binding domain; Region: LytTR; pfam04397
86416012766	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
86416012767	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
86416012768	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
86416012769	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
86416012770	homodimer interface [polypeptide binding]; other site
86416012771	substrate-cofactor binding pocket; other site
86416012772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416012773	catalytic residue [active]
86416012774	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
86416012775	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
86416012776	gluconate transporter; Region: gntP; TIGR00791
86416012777	fructuronate transporter; Provisional; Region: PRK10034; cl15264
86416012778	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
86416012779	fructuronate transporter; Provisional; Region: PRK10034; cl15264
86416012780	gluconate transporter; Region: gntP; TIGR00791
86416012781	Transcriptional regulators [Transcription]; Region: FadR; COG2186
86416012782	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416012783	DNA-binding site [nucleotide binding]; DNA binding site
86416012784	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
86416012785	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
86416012786	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
86416012787	substrate binding site [chemical binding]; other site
86416012788	ATP binding site [chemical binding]; other site
86416012789	Entner-Doudoroff aldolase; Region: eda; TIGR01182
86416012790	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
86416012791	active site
86416012792	intersubunit interface [polypeptide binding]; other site
86416012793	catalytic residue [active]
86416012794	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
86416012795	Transcriptional regulator [Transcription]; Region: IclR; COG1414
86416012796	Bacterial transcriptional regulator; Region: IclR; pfam01614
86416012797	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
86416012798	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
86416012799	putative dimer interface [polypeptide binding]; other site
86416012800	replicative DNA helicase; Provisional; Region: PRK05595
86416012801	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
86416012802	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
86416012803	Walker A motif; other site
86416012804	ATP binding site [chemical binding]; other site
86416012805	Walker B motif; other site
86416012806	DNA binding loops [nucleotide binding]
86416012807	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
86416012808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
86416012809	Walker A motif; other site
86416012810	ATP binding site [chemical binding]; other site
86416012811	Walker B motif; other site
86416012812	arginine finger; other site
86416012813	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
86416012814	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
86416012815	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
86416012816	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
86416012817	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
86416012818	DHH family; Region: DHH; pfam01368
86416012819	DHHA1 domain; Region: DHHA1; pfam02272
86416012820	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
86416012821	MazG-like family; Region: MazG-like; pfam12643
86416012822	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
86416012823	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
86416012824	DNA-binding site [nucleotide binding]; DNA binding site
86416012825	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
86416012826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
86416012827	homodimer interface [polypeptide binding]; other site
86416012828	catalytic residue [active]
86416012829	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
86416012830	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
86416012831	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
86416012832	MgtE intracellular N domain; Region: MgtE_N; smart00924
86416012833	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
86416012834	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
86416012835	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
86416012836	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
86416012837	dimer interface [polypeptide binding]; other site
86416012838	ssDNA binding site [nucleotide binding]; other site
86416012839	tetramer (dimer of dimers) interface [polypeptide binding]; other site
86416012840	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
86416012841	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
86416012842	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
86416012843	Mechanosensitive ion channel; Region: MS_channel; pfam00924
86416012844	LysE type translocator; Region: LysE; cl00565
86416012845	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
86416012846	Domain of unknown function DUF20; Region: UPF0118; pfam01594
86416012847	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
86416012848	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
86416012849	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
86416012850	ParB-like nuclease domain; Region: ParB; smart00470
86416012851	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
86416012852	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
86416012853	P-loop; other site
86416012854	Magnesium ion binding site [ion binding]; other site
86416012855	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
86416012856	Magnesium ion binding site [ion binding]; other site
86416012857	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
86416012858	ParB-like nuclease domain; Region: ParBc; pfam02195
86416012859	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
86416012860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
86416012861	S-adenosylmethionine binding site [chemical binding]; other site
86416012862	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
86416012863	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
86416012864	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
86416012865	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
86416012866	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
86416012867	trmE is a tRNA modification GTPase; Region: trmE; cd04164
86416012868	G1 box; other site
86416012869	GTP/Mg2+ binding site [chemical binding]; other site
86416012870	Switch I region; other site
86416012871	G2 box; other site
86416012872	Switch II region; other site
86416012873	G3 box; other site
86416012874	G4 box; other site
86416012875	G5 box; other site
86416012876	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
86416012877	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
86416012878	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
86416012879	G-X-X-G motif; other site
86416012880	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
86416012881	RxxxH motif; other site
86416012882	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
86416012883	Haemolytic domain; Region: Haemolytic; pfam01809
86416012884	ribonuclease P; Reviewed; Region: rnpA; PRK00499
86416012885	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
86416012886	Initiator Replication protein; Region: Rep_3; pfam01051
86416012887	Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527
86416012888	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
86416012889	Mg binding site [ion binding]; other site
86416012890	nucleotide binding site [chemical binding]; other site
86416012891	putative protofilament interface [polypeptide binding]; other site
86416012892	helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225
86416012893	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012894	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012895	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
86416012896	trimer interface [polypeptide binding]; other site
86416012897	active site
86416012898	substrate binding site [chemical binding]; other site
86416012899	CoA binding site [chemical binding]; other site
86416012900	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
86416012901	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
86416012902	putative active site [active]
86416012903	putative NTP binding site [chemical binding]; other site
86416012904	putative nucleic acid binding site [nucleotide binding]; other site
86416012905	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
86416012906	Rrf2 family protein; Region: rrf2_super; TIGR00738
86416012907	Transcriptional regulator; Region: Rrf2; pfam02082
86416012908	Flavodoxin domain; Region: Flavodoxin_5; cl17428
86416012909	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
86416012910	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
86416012911	Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
86416012912	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416012913	active site
86416012914	DNA binding site [nucleotide binding]
86416012915	Int/Topo IB signature motif; other site
86416012916	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012917	Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492
86416012918	active site
86416012919	catalytic triad [active]
86416012920	peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069
86416012921	peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost
86416012922	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
86416012923	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
86416012924	FeS/SAM binding site; other site
86416012925	putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065
86416012926	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
86416012927	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
86416012928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
86416012929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
86416012930	Walker A/P-loop; other site
86416012931	ATP binding site [chemical binding]; other site
86416012932	Q-loop/lid; other site
86416012933	ABC transporter signature motif; other site
86416012934	Walker B; other site
86416012935	D-loop; other site
86416012936	H-loop/switch region; other site
86416012937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
86416012938	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
86416012939	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
86416012940	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
86416012941	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
86416012942	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
86416012943	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
86416012944	glycosyltransferase, MGT family; Region: MGT; TIGR01426
86416012945	active site
86416012946	TDP-binding site; other site
86416012947	acceptor substrate-binding pocket; other site
86416012948	homodimer interface [polypeptide binding]; other site
86416012949	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
86416012950	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
86416012951	Multicopper oxidase; Region: Cu-oxidase; pfam00394
86416012952	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
86416012953	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
86416012954	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
86416012955	DNA binding residues [nucleotide binding]
86416012956	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
86416012957	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
86416012958	active site
86416012959	DNA binding site [nucleotide binding]
86416012960	Int/Topo IB signature motif; other site
86416012961	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
86416012962	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
86416012963	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
86416012964	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
86416012965	DNA binding residues [nucleotide binding]
86416012966	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
86416012967	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
86416012968	Transposase domain (DUF772); Region: DUF772; pfam05598
86416012969	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
86416012970	Homeodomain-like domain; Region: HTH_23; pfam13384
86416012971	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416012972	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416012973	non-specific DNA binding site [nucleotide binding]; other site
86416012974	salt bridge; other site
86416012975	sequence-specific DNA binding site [nucleotide binding]; other site
86416012976	Response regulator receiver domain; Region: Response_reg; pfam00072
86416012977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
86416012978	active site
86416012979	phosphorylation site [posttranslational modification]
86416012980	intermolecular recognition site; other site
86416012981	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
86416012982	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
86416012983	non-specific DNA binding site [nucleotide binding]; other site
86416012984	salt bridge; other site
86416012985	sequence-specific DNA binding site [nucleotide binding]; other site
86416012986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
86416012987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
86416012988	ATP binding site [chemical binding]; other site
86416012989	Mg2+ binding site [ion binding]; other site
86416012990	G-X-G motif; other site
86416012991	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697